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https://www.readbyqxmd.com/read/29924303/coi1-dependent-jasmonate-signalling-affects-growth-metabolite-production-and-cell-wall-protein-composition-in-arabidopsis
#1
Moritz Bömer, José A O'Brien, Imma Pérez-Salamó, Jovaras Krasauskas, Paul Finch, Andrea Briones, Arsalan Daudi, Puneet Souda, Tjir-Li Tsui, Julian P Whitelegge, G Paul Bolwell, Alessandra Devoto
Background and Aims: Cultured cell suspensions have been the preferred model to study the apoplast as well as to monitor metabolic and cell cycle-related changes. Previous work showed that methyl jasmonate (MeJA) inhibits leaf growth in a CORONATINE INSENSITIVE 1 (COI1)-dependent manner, with COI1 being the jasmonate (JA) receptor. Here, the effect of COI1 overexpression on the growth of stably transformed arabidopsis cell cultures is described. Methods: Time-course experiments were carried out to analyse gene expression, and protein and metabolite levels...
June 19, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29924301/effect-of-diurnal-variations-in-the-carbohydrate-and-fat-composition-of-meals-on-postprandial-glycemic-response-in-healthy-adults-a-novel-insight-for-the-second-meal-phenomenon
#2
Takafumi Ando, Satoshi Nakae, Chiyoko Usui, Eiichi Yoshimura, Nobuo Nishi, Hidemi Takimoto, Shigeho Tanaka
Background: Meals, particularly carbohydrate intake, determine diurnal blood glucose (BG) excursions. However, the effect of meals with variable carbohydrate content on diurnal BG excursions remains poorly understood, despite routine consumption of meals that vary daily. Objective: The aim of this study was to verify our hypothesis that glycemic response is elevated when a meal with a higher carbohydrate content follows a meal with a lower carbohydrate content. Design: This was a secondary analysis of a study whose primary endpoint was energy metabolism (e...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29923775/performance-of-a-factory-calibrated-real-time-continuous-glucose-monitoring-system-utilizing-an-automated-sensor-applicator
#3
Viral N Shah, Lori M Laffel, R Paul Wadwa, Satish K Garg
BACKGROUND: This study assessed the accuracy of a factory-calibrated 10-day real-time continuous glucose monitoring (CGM) system (G6), which includes an automated sensor applicator. METHODS: Seventy-six participants with insulin-treated diabetes were enrolled at four U.S. sites as part of a larger study of G6 system performance. In-clinic visits for frequent comparative blood glucose measurements using a reference instrument (YSI) were conducted on days 1, 4-5, 7, and/or 10 of system use...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29923774/healthcare-resource-waste-associated-with-patient-nonadherence-and-early-discontinuation-of-traditional-continuous-glucose-monitoring-in-real-world-settings-a-multicountry-analysis
#4
Shengsheng Yu, Biju Varughese, Zhiyi Li, Pam R Kushner
BACKGROUND: Traditional continuous glucose monitoring (CGM) provides detailed information on glucose patterns and trends to inform daily diabetes management decisions, which is particularly beneficial for patients with a history of hypoglycemia unawareness. However, a high level of patient adherence (≥70%) is required to achieve clinical benefits. The aim of this study was to assess the impact of real-world patient nonadherence and early discontinuation on healthcare resource use. METHODS: A cost calculator was designed to evaluate monthly healthcare resource waste within the first year of traditional CGM initiation by combining estimates of real-world nonadherence and early discontinuation from the literature with the wholesale acquisition costs of the current technology in the United States (for a commercial payer and for Medicare), or its equivalent in Sweden, Germany, or the Netherlands...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29923773/how-should-we-assess-glycemic-variability-in-type-1-diabetes-contribution-of-principal-component-analysis-for-interstitial-glucose-indices-in-142-children
#5
Sophie Guilmin-Crépon, Jean-Claude Carel, Julien Schroedt, Erwan Scornet, Corinne Alberti, Nadia Tubiana-Rufi
BACKGROUND: Glycemic variability (GV) can be used to assess glycemic control in diabetes, but there is no clear consensus concerning the methods to use for its assessment. Methodological differences have resulted in differences in the outcome of GV metrics used in research studies, controversies over clinical impact, and an absence of integration into routine care. AIM: To identify the indicators of GV most meaningful for clinicians, patients, and clinical researchers...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29923767/the-protective-role-of-trpc6-knockout-in-the-progression-of-diabetic-kidney-disease
#6
Denisha Spires, Daria V Ilatovskaya, Vladislav Levchenko, Paula E North, Aron M Geurts, Oleg Palygin, Alexander Staruschenko
Diabetic kidney disease (DKD) is a chronic kidney pathology that leads to end stage renal disease. Previous studies from our laboratory indicate that there is an association between the development of DKD and the TRPC6 channel. Trpc6 expression and activity was increased in the streptozotocin (STZ)-treated Dahl Salt-sensitive (SS) rat, an established model of type 1 diabetes. Here, using a Trpc6 knock-out created on the SS rat background (SSTRPC6-/- ), we test the hypothesis that the absence of Trpc6 will protect podocytes and kidney function during the development of DKD...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29923262/continuous-glucose-monitoring-cgm-and-glycemic-control-among-youth-with-type-1-diabetes-t1d-international-comparison-from-the-t1d-exchange-and-dpv-initiative
#7
Daniel J DeSalvo, Kellee M Miller, Julia M Hermann, David M Maahs, Sabine E Hofer, Mark A Clements, Eggert Lilienthal, Jennifer L Sherr, Martin Tauschmann, Reinhard W Holl
BACKGROUND: To assess change in rates of pediatric real time or intermittent scanning CGM use over the past 5 years, and how it impacts glycemic control, data from 2 registries were compared: the US-based T1DX and the German/Austrian DPV. METHODS: Registry participants aged <18 years with T1D duration ≥ 1 year encompassed 29,007 individuals in 2011 and 29,150 participants in 2016. Demographic data, CGM use and HbA1c were obtained from medical records. RESULTS: CGM use increased from 2011 to 2016 in both registries across all age groups, regardless of gender, ethnic minority status or insulin delivery method...
June 20, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29923016/incidence-and-management-of-postoperative-hyperglycemia-in-patients-undergoing-insulinoma-resection
#8
Pavel Nockel, Amit Tirosh, Mustapha El Lakis, Apostolos Gaitanidis, Roxanne Merkel, Dhaval Patel, Naris Nilubol, Samira M Sadowski, Craig Cochran, Phillip Gorden, Electron Kebebew
PURPOSE: It has been proposed that rebound hyperglycemia after resection of insulinoma indicates a biochemical cure. However, there is scant objective data in the literature on the rate and need for intervention in hyperglycemia in patients undergoing resection of insulinoma. The goal of our study was to evaluate the rate of postoperative hyperglycemia, any predisposing factors, and the need for intervention in a prospective cohort study of all patients undergoing routine glucose monitoring...
June 19, 2018: Endocrine
https://www.readbyqxmd.com/read/29922353/the-glucocoper-a-tool-for-the-assessment-of-coping-mechanisms
#9
Sanjay Kalra, Yatan Pal Singh Balhara, Komal Verma, Bharti Kalra
Diabetes distress - commonly encountered as a part of life with diabetes mellitus - can be effectively managed by coping skills training. Systematic assessment and documentation of the existing coping skills (and lack thereof) is a pre-requisite for planning such coping skills training. A six-item tool, the GlucoCoper - which assesses two negative (resistance, blame) and four positive (acceptance, optimism, planning and action) coping mechanisms - was administered to English-literate adult participants with type 2 diabetes (T2DM) at an endocrine centre in India...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29922351/effect-of-body-lotions-on-capillary-blood-glucose-measurement-interference-of-hydroquinone-containing-body-lotion-with-capillary-glucose-measurement
#10
Andrea Ma Omengue, Eugène Sobngwi, Mesmin Dehayem, Eric V Balt, Anne Mo Boli, Simeon P Choukem, Jean F Gautier, Jean-Claude Mbanya
The reliability of capillary blood glucose measurements is tremendously important for patients' care and follow-up. Some factors independent of glucose control could however affect readings during ambulatory monitoring of capillary glucose levels in patients with diabetes mellitus. We sought to evaluate the impact of three body lotions commonly used in Cameroon on different strata of glycaemia. We explored their influence over time on measured capillary glucose values. We enrolled 16 participants. Eligible individuals were adult patients with diabetes (n=12) stratified into three levels of capillary glucose values (100 ± 40 mg/dL [5...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29922348/selecting-the-appropriate-continuous-glucose-monitoring-system-a-practical-approach
#11
REVIEW
Peter Adolfsson, Christopher G Parkin, Andreas Thomas, Lars G Krinelke
Two types of continuous glucose monitoring (CGM) systems are currently available for daily diabetes self-management: real-time CGM and intermittently scanned CGM. Both approaches provide continuous measurement of glucose concentrations in the interstitial fluid; however, each has its own unique features that can impact their usefulness and acceptability within specific patient groups. This article explores the strengths and limitations of each approach and provides guidance to healthcare professionals in selecting the CGM type that is most appropriate to the individual needs of their patients...
April 2018: European Endocrinology
https://www.readbyqxmd.com/read/29922042/adherence-to-diabetic-self-care-practices-and-its-associated-factors-among-patients-with-type-2-diabetes-in-addis-ababa-ethiopia
#12
Zeleke Bonger, Solomon Shiferaw, Eshetu Zerihun Tariku
Background: Self-care practices in diabetes patients are crucial to keep the illness under control and prevent complications. Effective management of diabetes will be a difficult task without adequate understanding of the existing level of practice related to diabetes self-care. This study is, therefore, aimed at assessing the self-care practice and its associated factors among patients with type 2 diabetes in Tikur Anbessa Specialized Hospital, Ethiopia. Materials and methods: A health facility-based cross-sectional study was conducted among 419 type 2 diabetes patients from March 29, 2013, to May 16, 2013...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29917259/poor-sleep-quality-is-associated-with-nocturnal-glycemic-variability-and-fear-of-hypoglycemia-in-adults-with-type-1-diabetes
#13
Pamela Martyn-Nemeth, Shane A Phillips, Dan Mihailescu, Sarah S Farabi, Chang Park, Rebecca Lipton, Esema Idemudia, Laurie Quinn
AIMS: To examine sleep quality and its associations with glycemic control, glycemic variability and fear of hypoglycemia in adults with type 1 diabetes. BACKGROUND: Poor sleep quality has negative health consequences and is a frequent complaint among adults with type 1 diabetes. Sleep quality in adults with type 1 diabetes is likely affected by glucose levels as well as stressors associated with managing a chronic condition. DESIGN: A retrospective secondary analysis of pooled data from two previous cross-sectional studies was conducted...
June 19, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29916742/glucose-variability-a-review-of-clinical-applications-and-research-developments
#14
David Rodbard
Glycemic variability (GV) is a major consideration when evaluating quality of glycemic control. GV increases progressively from prediabetes through advanced T2D and is still higher in T1D. GV is correlated with risk of hypoglycemia. The most popular metrics for GV are the %Coefficient of Variation (%CV) and standard deviation (SD). The %CV is correlated with risk of hypoglycemia. Graphical display of glucose by date, time of day, and day of the week, and display of simplified glucose distributions showing % of time in several ranges, provide clinically useful indicators of GV...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29916740/preserving-skin-integrity-with-chronic-device-use-in-diabetes
#15
Laurel H Messer, Cari Berget, Christie Beatson, Sarit Polsky, Gregory P Forlenza
Skin integrity and diabetes device placement are ongoing concerns for people with diabetes who utilize continuous glucose monitors (CGMs) and continuous subcutaneous insulin infusion pumps. This is especially significant for individuals with skin sensitivities, pediatric patients, and those who use devices chronically. Dermatological complications are often cited as a barrier to device use and a reason for device discontinuation. Furthermore, it is a frequent topic of discussion in diabetes follow-up visits, although little evidence-based literature exists to guide providers in managing skin integrity issues...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29916738/emerging-technologies-for-diabetes-care
#16
Timothy S Bailey, John Walsh, Jenine Y Stone
New therapies, monitoring, and revolutionary enabling technologies applied to healthcare represent an historic opportunity to improve the lives of people with diabetes. These advances enable more meaningful monitoring of blood glucose values with the facilitation of more optimal insulin dosing and delivery. Newer insulins and delivery systems are in development that seek to mitigate both hyperglycemia and hypoglycemia and increase time in range. Information systems now exist that may be leveraged to merge data from previously discrete systems into new models of connected care...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29916736/role-of-continuous-glucose-monitoring-in-insulin-requiring-patients-with-diabetes
#17
John B Welsh
No abstract text is available yet for this article.
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29916308/the-mtor-pathway-regulates-pkm2-to-affect-glycolysis-in-esophageal-squamous-cell-carcinoma
#18
He Xiaoyu, Yin Yiru, Shi Shuisheng, Cheng Keyan, Yan Zixing, Cheng Shanglin, Wang Yuan, Cheng Dongming, Zhang Wangliang, Bai Xudong, Ma Jie
OBJECTIVES: Esophageal squamous cell carcinoma is a highly prevalent cancer withpoor survival rate and prognosis. Increasing evidence suggests an important role for metabolic regulation in treating esophageal squamous cell carcinoma, but the underlying mechanism remains unclear. The pyruvate kinase M2 isoform is a key enzyme in the energy production process, and the upregulation of pyruvate kinase M2 isoform also plays a crucial role in gene transcription and tumorigenesis. The mammalian target of rapamycin pathway regulates an array of cellular functions, including protein synthesis, metabolism, and cell proliferation...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29916102/associations-of-serum-glucagon-levels-with-glycemic-variability-in-type-1-diabetes-with-different-disease-durations
#19
Ke Li, Wen-Jing Song, Xia Wu, Dan-Yang Gu, Pu Zang, Ping Gu, Bin Lu, Jia-Qing Shao
PURPOSE: Glucagon has been recognized as a pivotal factor implicated in the pathophysiology ofdiabetes. The purpose of this study is to investigate the dynamic secretion levels of serum glucagon (GLA) in patients with type 1 diabetes mellitus (T1DM) with different courses of disease, and to analyze its correlation with blood glucose fluctuation. METHODS: This observational study included 55 T1DM patients and divided into 3 groups according to the courses of disease...
June 18, 2018: Endocrine
https://www.readbyqxmd.com/read/29915545/a-minimal-model-approach-for-analyzing-continuous-glucose-monitoring-in-type-2-diabetes
#20
Pranay Goel, Durga Parkhi, Amlan Barua, Mita Shah, Saroj Ghaskadbi
Continuous glucose monitoring (CGM), a technique that records blood glucose at a regular intervals. While CGM is more commonly used in type 1 diabetes, it is increasingly becoming attractive for treating type 2 diabetic patients. The time series obtained from a CGM provides a rich picture of the glycemic state of the subjects and may help have tighter control on blood sugar by revealing patterns in their physiological responses to food. However, despite its importance, the biophysical understanding of CGM is far from complete...
2018: Frontiers in Physiology
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