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https://www.readbyqxmd.com/read/29475022/association-between-depressive-symptoms-and-dietary-intake-in-patients-with-type-1-diabetes
#1
Aila J Ahola, Carol Forsblom, Per-Henrik Groop
AIMS: Depressive mood negatively affects self-care practices, and thereby increases the risk of long-term complications. Not much is known about the association between depressive symptoms and dietary intake in patients with type 1 diabetes, a population with high risk of cardiovascular disease. METHODS: Subjects (n=976, 41% men, age 48±14 years) were participants in the Finnish Diabetic Nephropathy Study. Depressive symptomatology was assessed with the Beck Depression Inventory (BDI)...
February 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29473001/body-mass-index-influences-the-plasma-glucose-concentration-during-iatrogenic-hypoglycemia-in-people-with-type-2-diabetes-mellitus-a-cross-sectional-study
#2
Po Chung Cheng, Shang Ren Hsu, Shih Te Tu, Yun Chung Cheng, Yu Hsiu Liu
Background: Hypoglycemia occurs in an appreciable number of individuals with type 2 diabetes mellitus (T2DM) who are receiving glycemic therapy. Iatrogenic hypoglycemia induces not only complications but also a substantial medical expense. Intervention for relevant risk factors may help avert severe hypoglycemia and enhance quality of life in at-risk individuals. This study investigates the relationship between body mass index (BMI) and plasma glucose concentration during iatrogenic hypoglycemia in people with T2DM...
2018: PeerJ
https://www.readbyqxmd.com/read/29471473/bidirectional-gpr119-agonism-requires-peptide-yy-and-glucose-for-activity-in-mouse-and-human-colon-mucosa
#3
Iain R Tough, Sarah Forbes, Herbert Herzog, Robert M Jones, Thue W Schwartz, Helen M Cox
The lipid sensor GPR119 is highly expressed by enteroendocrine L-cells and pancreatic β-cells that release the hormones, PYY and GLP-1, and insulin, respectively. Endogenous oleoylethanolamide (OEA) and the dietary metabolite, 2-monoacylglycerol (2-OG) can each activate GPR119. Here we compared mucosal responses to selective, synthetic GPR119 agonists (AR440006, AR231453) and the lipids, OEA, 2-OG and N-oleoyldopamine (OLDA) monitoring epithelial ion transport as a read-out for L-cell activity in native mouse and human gastrointestinal (GI) mucosae...
February 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29471280/stretchable-wireless-system-for-sweat-ph-monitoring
#4
Wenting Dang, Libu Manjakkal, William Taube Navaraj, Leandro Lorenzelli, Vincenzo Vinciguerra, Ravinder Dahiya
Sensor-laden wearable systems that are capable of providing continuous measurement of key physiological parameters coupled with data storage, drug delivery and feedback therapy have attracted huge interest. Here we report a stretchable wireless system for sweat pH monitoring, which is able to withstand up to 53% uniaxial strain and more than 500 cycles to 30% strain. The stretchability of the pH sensor patch is provided by a pair of serpentine-shaped stretchable interconnects. The pH sensing electrode is made of graphite-polyurethane composite, which is suitable for biosensor application...
February 10, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29471242/development-of-a-glucose-sensor-employing-quick-and-easy-modification-method-with-mediator-for-altering-electron-acceptor-preference
#5
Mika Hatada, Noya Loew, Yuka Inose-Takahashi, Junko Okuda-Shimazaki, Wakako Tsugawa, Ashok Mulchandani, Koji Sode
Enzyme based electrochemical biosensors are divided into three generations according to their type of electron transfer from the cofactors of the enzymes to the electrodes. Although the 3rd generation sensors using direct electron transfer (DET) type enzymes are ideal, the number of enzyme types which possess DET ability is limited. In this study, we report of a glucose sensor using mediator-modified glucose dehydrogenase (GDH), that was fabricated by a new quick-and-easy method using the pre-functionalized amine reactive phenazine ethosulfate (arPES)...
February 9, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29470174/antidiabetic-and-protective-effects-of-the-aqueous-extract-of-arbutus-unedo-l-in-streptozotocin-nicotinamide-induced-diabetic-mice
#6
Hanae Naceiri Mrabti, Karima Sayah, Nidal Jaradat, Faouzi Kichou, Abdelaziz Ed-Dra, Badiaa Belarj, Yahia Cherrah, My El Abbes Faouzi
Background Diabetes mellitus (DM) is currently a major health problem and the most common chronic disease worldwide. Traditional medicinal plants remedies remain a potential adjunct therapy to maintain better glycemic control while also imparting few side-effects. Arbutus unedo L. has been traditionally used to manage several diseases including diabetes. This study was undertaken to contribute the validation of the traditional use of Arbutus unedoL. (Ericaceae) in the treatment of diabetes. Methods In-vitro antidiabetic effect of the A...
February 21, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29470128/human-subcutaneous-tissue-response-to-glucose-sensors-macrophages-accumulation-impact-on-sensor-accuracy
#7
Mercedes Rigla, Belén Pons, Pere Rebasa, Alexis Luna, Francisco Javier Pozo, Assumpta Caixàs, Maria Villaplana, David Subías, Maria Rosa Bella, Neus Combalia
BACKGROUND: Subcutaneous (s.c.) glucose sensors have become a key component in type 1 diabetes management. However, their usability is limited by the impact of foreign body response (FBR) on their duration, reliability, and accuracy. Our study gives the first description of human acute and subacute s.c. response to glucose sensors, showing the changes observed in the sensor surface, the inflammatory cells involved in the FBR and their relationship with sensor performance. METHODS: Twelve obese patients (seven type 2 diabetes) underwent two abdominal biopsies comprising the surrounding area where they had worn two glucose sensors: the first one inserted 7 days before and the second one 24 h before biopsy procedure...
February 22, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29470094/accuracy-user-acceptability-and-safety-evaluation-for-the-freestyle-libre-flash-glucose-monitoring-system-when-used-by-pregnant-women-with-diabetes
#8
Eleanor M Scott, Rudy W Bilous, Alexandra Kautzky-Willer
BACKGROUND: Accuracy of the FreeStyle Libre™ Flash Glucose Monitoring System has not been evaluated in pregnant women with diabetes. The aim of this study was to determine accuracy (compared to self-monitoring of blood glucose [SMBG]), clinical safety, and acceptability of the FreeStyle Libre System when used at home by this population. MATERIALS AND METHODS: Seventy-four participants, with type 1 (T1D, n = 24), type 2 (T2D, n = 11), or gestational (n = 39) diabetes, were enrolled across 13 sites (9 in United Kingdom, 4 in Austria)...
February 22, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29469970/glimepiride-treatment-in-a-patient-with-type-a-insulin-resistance-syndrome-due-to-a-novel-heterozygous-missense-mutation-in-the-insulin-receptor-gene
#9
Zhimin Huang, Juan Liu, Kaka Ng, Xuesi Wan, Lijuan Xu, Xiaoying He, Zhihong Liao, Yanbing Li
AIMS: Glimepiride is a sulfonylurea known to have unique insulin mimetic and sensitizing effect. We aimed to study the efficacy of glimepiride in a patient with type A insulin resistance syndrome. METHODS: A 15-year-old female with type A insulin resistance syndrome was treated with glimpiride for 6 months. Self-monitoring of blood glucose was recorded, OGTTs on glucose and insulin were measured during the treatment. Hyperinsulinemic euglycemic clamp was used to evaluate whole body insulin sensitivity before and after the treatment...
February 22, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29466668/quantitative-analysis-of-glucose-metabolic-cleavage-in-glucose-transporters-overexpressed-cancer-cells-by-target-specific-fluorescent-gold-nanoclusters
#10
Tsai-Mu Cheng, Hsueh-Liang Chu, Yi-Cheng Lee, Di-Yan Wang, Che-Chang Chang, Kuan-Lan Chung, Hung-Chi Yen, Chu-Wen Hsiao, Xi-Yu Pan, Tsung-Rong Kuo, Chia-Chun Chen
The glucose metabolism rate in cancer cells is a crucial piece of information for the cancer aggressiveness. A feasible method to monitor processes of oncogenic mutations has been demonstrated in this work. The fluorescent gold nanoclusters conjugated with glucose (glucose-AuNCs) were successfully synthesized as a cancer-targeting probe for glucose transporters (Gluts) overexpressed by U-87 MG cancer cells, which can be observed under confocal microscopy. The structural and optical characterizations of fluorescent glucose-AuNCs were confirmed by transmission electron microscope (TEM) and Fourier transform infrared spectroscopy (FTIR)...
February 21, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29465156/the-impact-of-serum-adropin-and-ischemia-modified-albumin-levels-based-on-bmi-in-pcos
#11
Zeynep Ozturk Inal, Sami Erdem, Yavuz Gederet, Cevdet Duran, Zehra Kucukaydin, Huseyin Kurku, Derya Kilic Sakarya
INTRODUCTION: The aim of this study was to evaluate the effects of polycystic ovary syndrome (PCOS) and body mass index (BMI) on serum adropin and ischemia modified albumin (IMA) levels. MATERIALS AND METHODS: This prospective cross-sectional study was performed with a total of 120 women [group1; non-PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30) and group 2; PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30)]. Blood samples were collected between the third and fifth days of the women's menstrual cycles after a night of fasting...
February 21, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29464891/continuous-glucose-monitoring-a-review-of-the-evidence-opportunities-for-future-use-and-ongoing-challenges
#12
Anna Wood, David O'Neal, John Furler, Elif I Ekinci
The advent of devices that can track interstitial glucose levels which are closely related to blood glucose levels on a near continuous basis has facilitated better insights into patterns of glycaemia. Continuous glucose monitoring (CGM) therefore allows for more intensive monitoring of blood glucose levels and potentially improved glycaemic control. In the context of the announcement on 1 April 2017 that the Australian Government will fund CGM monitoring for people with type 1 diabetes under the age of 21, this paper provides a review of the evidence for CGM and some of the ongoing challenges...
February 21, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29463309/zanthoxylum-armatum-dc-extracts-from-fruit-bark-and-leaf-induce-hypolipidemic-and-hypoglycemic-effects-in-mice-in-vivo-and-in-vitro-study
#13
Fiaz Alam, Qazi Najam Us Saqib, Mohammad Ashraf
BACKGROUND: Zanthoxylum armatum DC is an important medicinal plant of south East Asia, and has been used to treat various ailments in traditional medicine including diabetes. This study investigated the in vitro and in vivo antidiabetic and biochemical effects of extracts of Z. armatum in mice. METHOD: The extracts of fruit, bark and leaf from Z. armatum were tested for α-glucosidase inhibition activity. Albino mice of either sex weighing (26-30 g) assigned into groups...
February 20, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29462907/spectral-optical-readout-of-rectangular-miniature-hollow-glass-tubing-for-refractive-index-sensing
#14
Giulia Rigamonti, Valentina Bello, Sabina Merlo
For answering the growing demand of innovative micro-fluidic devices able to measure the refractive index of samples in extremely low volumes, this paper presents an overview of the performances of a micro-opto-fluidic sensing platform that employs rectangular, miniature hollow glass tubings. The operating principle is described by showing the analytical model of the tubing, obtained as superposition of different optical cavities, and the optical readout method based on spectral reflectivity detection. We have analyzed, in particular, the theoretical and experimental optical features of rectangular tubings with asymmetrical geometry, thus with channel depth larger than the thickness of the glass walls, though all of them in the range of a few tens of micrometers...
February 16, 2018: Sensors
https://www.readbyqxmd.com/read/29462809/liver-plays-a-major-role-in-fgf-21-mediated-glucose-homeostasis
#15
Mingyao Liu, Hongwei Cao, Yuting Hou, Guopeng Sun, Deshan Li, Wenfei Wang
BACKGROUND/AIMS: The liver is a vital organ in vertebrates and has a wide range of functions, including glucose absorption, glycogen storage and glucose production. Fibroblast growth factor (FGF)-21 is a metabolic regulator that is primarily produced by the liver. In this paper, we studied the effect of FGF-21 on glucose metabolism in the liver. METHODS: The glucose uptake of cells was detected by 2-Deoxy-d-[3H] glucose; the synergy between insulin and FGF-21 was evaluated...
February 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29462296/public-health-monitoring-of-hypertension-diabetes-and-elevated-cholesterol-comparison-of-different-data-sources
#16
Laura Paalanen, Päivikki Koponen, Tiina Laatikainen, Hanna Tolonen
Background: Three data sources are generally used in monitoring health on the population level. Health interview surveys (HISs) are based on participants' self-report. Health examination surveys (HESs) yield more objective data, and also persons who are unaware of their elevated risks can be detected. Medical records (MRs) and other administrative registers also provide objective data, but their availability, coverage and quality vary between countries. We summarized studies comparing self-reported data with (i) measured data from HESs or (ii) MRs...
February 16, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29461848/leveraging-benefit-design-for-better-diabetes-self-management-and-a1c-control
#17
Abiy Agiro, Yiqiong Xie, Kevin Bowman, Andrea DeVries
OBJECTIVES: To evaluate the relationship between cost sharing for blood glucose testing strips and glycemic control rates. STUDY DESIGN: A retrospective observational study using medical and pharmacy claims data integrated with laboratory glycated hemoglobin (A1C) values for patients using insulin and testing strips. A new user study design was utilized to identify individuals from 14 commercial US health plans who filled testing strips with assumed intention to monitor blood glucose...
February 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29461044/antibiotic-susceptibility-determination-within-one-cell-cycle-at-single-bacterium-level-by-stimulated-raman-metabolic-imaging
#18
Weili Hong, Caroline W Karanja, Nader S Abutaleb, Waleed Younis, Xueyong Zhang, Mohamed N Seleem, Ji-Xin Cheng
The widespread use of antibiotics has significantly increased the number of resistant bacteria, which has also increased the urgency of rapid bacterial detection and profiling their antibiotic response. Current clinical methods for antibiotic susceptibility testing (AST) rely on culture and require at least 16 to 24 h to conduct. Therefore, there is an urgent need for a rapid method that can test the susceptibility of bacteria in a culture-free manner. Here we demonstrate a rapid AST method by monitoring the glucose metabolic activity of live bacteria at the single cell level with hyperspectral stimulated Raman scattering (SRS) imaging...
February 20, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29460474/specific-synbiotics-in-early-life-protect-against-diet-induced-obesity-in-adult-mice
#19
Mona Mischke, Tulika Arora, Sebastian Tims, Eefje Engels, Nina Sommer, Kees van Limpt, Annemarie Baars, Raish Oozeer, Annemarie Oosting, Fredrik Bäckhed, Jan Knol
AIMS: The metabolic state of human adults is associated with their gut microbiome. The symbiosis between host and microbiome is initiated at birth, and early life microbiome perturbation can disturb health long-lastingly. Here, we determined how beneficial microbiome interventions in early life affect metabolic health in adulthood. METHODS: Postnatal diets were supplemented with either prebiotics (scGOS/lcFOS) or synbiotics (scGOS/lcFOS with Bifidobacterium breve M-16V) until post-natal (PN) day 42 in a well-established rodent model for nutritional programming...
February 20, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29459022/continuous-glucose-monitoring-transforming-diabetes-management-step-by-step
#20
Richard M Bergenstal
No abstract text is available yet for this article.
February 15, 2018: Lancet
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