keyword
MENU ▼
Read by QxMD icon Read
search

micronucleus test in chromium and nickel

keyword
https://www.readbyqxmd.com/read/27894683/biomonitoring-of-humans-exposed-to-arsenic-chromium-nickel-vanadium-and-complex-mixtures-of-metals-by-using-the-micronucleus-test-in-lymphocytes
#1
REVIEW
Balasubramanyam Annangi, Stefano Bonassi, Ricard Marcos, Alba Hernández
Various metals have demonstrated genotoxic and carcinogenic potential via different mechanisms. Until now, biomonitoring and epidemiological studies have been carried out to assess the genotoxic risk to exposed human populations. In this sense, the use of the micronucleus assay in peripheral blood lymphocytes has proven to be a useful tool to determine increased levels of DNA damage, as a surrogate biomarker of cancer risk. Here we review those biomonitoring studies focused on people exposed to arsenic, chromium, nickel, vanadium and complex mixtures of metals...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/26610685/icp-oes-and-micronucleus-test-to-evaluate-heavy-metal-contamination-in-commercially-available-brazilian-herbal-teas
#2
Priscila Francisca Tschaen Schunk, Ieda Carneiro Kalil, Elisangela Flavia Pimentel-Schmitt, Dominik Lenz, Tadeu Uggere de Andrade, Juliano Souza Ribeiro, Denise Coutinho Endringer
Increased tea consumption in combination with intensive pesticide use is generating heavy metal contaminations amongst Brazilian tea consumers, causing health concerns. Inductively coupled plasma optical emission spectrometry (ICP-OES) was applied to quantify minerals and heavy metals such as aluminum, barium, cadmium, lead, cobalt, copper, chromium, tin, manganese, molybdenum, nickel, selenium, silver, thallium, vanadium and zinc in Brazilian chamomile, lemongrass, fennel and yerba mate teas. Teas, purchased in local supermarkets, were prepared using infusion and acid digestion...
July 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/26191657/in-vivo-induction-of-antioxidant-response-and-oxidative-stress-associated-with-genotoxicity-and-histopathological-alteration-in-two-commercial-fish-species-due-to-heavy-metals-exposure-in-northern-india-kali-river
#3
Mahino Fatima, Nazura Usmani, Fakiha Firdaus, Mohammad Faraz Zafeer, Shafeeque Ahmad, Kafil Akhtar, S M Dawar Husain, Mir Hilal Ahmad, Ehraz Anis, M Mobarak Hossain
Heavy metals can significantly bioaccumulate in fish tissues. The step wise mechanism of heavy metal toxicities on fish health is still limited. The present study assessed the tissue-specific antioxidant response and oxidative stress biomarkers of commercially important fish species namely, Channa striatus and Heteropneustes fossilis inhabiting Kali River of northern India where heavy-metal load is beyond the World Health Organisation - maximum permissible limits. Heavy metals chromium (Cr), nickel (Ni), lead (Pb) and cadmium (Cd) were elevated in both fish species compared to recommended values of the Federal Environmental Protection Agency (FEPA), 1999 for edible fishes...
October 2015: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/24756201/assessment-of-genotoxic-induction-and-deterioration-of-fish-quality-in-commercial-species-due-to-heavy-metal-exposure-in-an-urban-reservoir
#4
Mahino Fatima, Nazura Usmani, M Mobarak Hossain, Mohammad Faisal Siddiqui, Mohammad Faraz Zafeer, Fakiha Firdaus, Shafeeque Ahmad
The aim of the study was to evaluate the effect of heavy-metal contamination on two fish species (Channa striatus and Heteropneustes fossilis) inhabiting a small freshwater body of northern India. After being captured, each specimen was weighed, measured, and analyzed for heavy metals (chromium [Cr], nickel [Ni], and lead [Pb]). Accumulation of heavy metals was found to be significantly greater (p < 0.05) in different tissues (gill, liver, kidney, and muscle) of fishes captured from the reservoir than from the reference site...
August 2014: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/21889083/evaluation-of-the-genotoxic-effects-of-fixed-appliances-on-oral-mucosal-cells-and-the-relationship-to-nickel-and-chromium-concentrations-an-in-vivo-study
#5
Madhumitha Natarajan, Sridevi Padmanabhan, Arun Chitharanjan, Malathi Narasimhan
INTRODUCTION: The release of metal ions from fixed orthodontic appliances is a source of concern. The aim of this study was to evaluate genotoxic damage in the oral mucosal cells of patients wearing fixed appliance, and the nickel and chromium ion contents in these cells. METHODS: Twenty patients undergoing orthodontic treatment formed the experimental group, and 20 untreated subjects comprised the control group. Oral mucosal smears were collected at 2 times: at debonding and 30 days after debonding...
September 2011: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/21636684/effect-of-nickel-and-chromium-exposure-on-buccal-cells-of-electroplaters
#6
Saba Qayyum, Anjum Ara, Jawed Ahmad Usmani
The electroplating industry commonly involves the use of nickel and chromium. An assessment of the genotoxic effects of these metals can be carried out by micronucleus (MN) test in buccal cells. Other nuclear anomalies (NA) observed in buccal cells viz., karyorrhexis, pyknosis and karyolysis are also the indicators of genotoxicity. The current study aims at determining the extent of genotoxic damage in relation to the duration of exposure to nickel and hexavalent chromium via micronuclei induction and other nuclear anomalies...
February 2012: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/21458593/in-vitro-genotoxicity-data-of-nanomaterials-compared-to-carcinogenic-potency-of-inorganic-substances-after-inhalational-exposure
#7
REVIEW
Markus Roller
Literature data of epidemiological studies, carcinogenicity studies and in vitro studies on inorganic substances were surveyed with the aim to determine sensitivity and specificity of in vitro tests of nanomaterials. Asbestos, quartz and chromium and cadmium compounds were assigned to classes of highest carcinogenic potency. After 20 years of occupational exposure to long-term average concentrations of 0.5mg/m(3) of these dusts - or to even lower concentrations - an epidemiologically detectable increased lung cancer risk has to be expected...
May 2011: Mutation Research
https://www.readbyqxmd.com/read/21435548/biomonitoring-of-mutagenicity-and-cytotoxicity-in-patients-undergoing-fixed-orthodontic-therapy
#8
Fernanda Angelieri, Viviane Carlin, Renato A Martins, Daniel A Ribeiro
INTRODUCTION: The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated buccal mucosa cells from adults after fixed orthodontic therapy. MATERIAL AND METHODS: A total of 23 healthy adults (10 men and 13 women) undergoing orthodontic therapy were included in this setting. RESULTS: The results pointed out no significant statistically differences (P >0.05) of micronucleated oral mucosa cells...
April 2011: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/20740446/evaluation-of-genotoxicity-of-recycled-ni-cr-dental-casting-alloys-an-in-vitro-study
#9
S C Tripuraneni, S K Namburi
This study was conducted to evaluate the genotoxicity of nickel-chromium (Ni-Cr) base metal alloys in their reused state at different time intervals. Two commercially available Ni-Cr alloys (Wiron 99, remanium Cse) were evaluated. Three groups of alloy specimens (disks 3 mm x 5 mm) were fabricated from each of these alloys. The first groups were made with 100% new alloy, the second groups with 50 wt% of new alloy and 50 wt% of once used alloy and the third groups with 100% once used alloy. Distilled water conditioned with the alloy specimens for four time intervals of 1, 2, 4 and 8 weeks was used for testing the genotoxicity on Chinese hamster V79-HG04 fibroblasts using the micronucleus assay...
January 2008: Journal of Applied Biomaterials & Biomechanics: JABB
https://www.readbyqxmd.com/read/19065761/in-vivo-determination-of-genotoxicity-induced-by-metals-from-orthodontic-appliances-using-micronucleus-and-comet-assays
#10
G H Westphalen, L M Menezes, D Prá, G G Garcia, V M Schmitt, J A P Henriques, R Medina-Silva
Orthodontic appliances are usually made of stainless steel, which contains metals such as nickel, chromium and iron that have been associated with DNA damage. The aim of the present study was to determine the genetic toxicity associated with orthodontic fixed appliances in twenty healthy patients (16 +/- 2.5 years) undergoing orthodontic treatment (fixed appliances - basic composition: stainless steel alloy), using the micronucleus (MN) and comet (CA) assays in buccal cells. Primary DNA damage level, as assessed by the CA, was low either before the beginning (1...
2008: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/17176674/cytogenetic-effects-of-a-mixture-of-selected-metals-following-subchronic-exposure-through-drinking-water-in-male-rats
#11
S H Jadhav, S N Sarkar, H C Tripathit
The current study examines the genotoxic effects of subchronic exposure via drinking water to a mixture of eight metals (arsenic, cadmium, lead, mercury, chromium, nickel, manganese and iron) found as contaminants of water sources in different parts of India and its possible association with oxidative stress. Male rats were exposed to the mixture at 0, 1, 10 and 100 times the mode concentration of each metal daily for 90 days. Another dose group at concentration equivalent to maximum permissible limit (MPL) for each metal and a reference group given ip cyclophosphamide were incorporated...
December 2006: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/16586500/in-vivo-genotoxic-effects-of-industrial-waste-leachates-in-mice-following-oral-exposure
#12
COMPARATIVE STUDY
Saurabh Chandra, Lalit K S Chauhan, Alok Dhawan, Ramesh C Murthy, Shrawan K Gupta
Contamination of ground water by industrial waste poses potential health hazards for man and his environment. The improper disposal of toxic wastes could allow genotoxic chemicals to percolate into ground waters, and these contaminated ground waters may produce toxicity, including mutation and eventually cancer, in exposed individuals. In the present study, we evaluated the in vivo genotoxic potential of leachates made from three different kinds of industrial waste (tannery waste, metal-based waste, and waste containing dyes and pigments) that are disposed of in areas adjoining human habitation...
June 2006: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/16234265/risk-assessment-of-welders-using-analysis-of-eight-metals-by-icp-ms-in-blood-and-urine-and-dna-damage-evaluation-by-the-comet-and-micronucleus-assays-influence-of-xrcc1-and-xrcc3-polymorphisms
#13
G Iarmarcovai, I Sari-Minodier, F Chaspoul, C Botta, M De Méo, T Orsière, J L Bergé-Lefranc, P Gallice, A Botta
The aims of the present study were to assess the occupational risk of welders using analysis of metals in biological fluids, DNA damage evaluation by complementary genotoxic endpoints and the incidence of polymorphisms in DNA repair genes. A biomonitoring study was conducted that included biometrology (blood and urinary concentrations of aluminium, cadmium, chromium, cobalt, lead, manganese, nickel, zinc by ICP-MS), comet and cytokinesis-block micronucleus assays in peripheral lymphocytes and genetic polymorphisms of XRCC1 (p...
November 2005: Mutagenesis
https://www.readbyqxmd.com/read/15635268/monitoring-of-lymphocyte-micronuclei-among-newborns-from-kragujevac-in-central-serbia-before-and-after-environmental-contamination
#14
Olivera Milosevic-Djordjevic, Darko Grujicic, Slobodan Arsenijevic, Dragoslav Marinkovic
The air strikes on "Zastava" complex in Kragujevac, in the spring of 1999, caused extensive environmental pollution with damage to soil, water and air. Since the main problem was the leakage of several tones of polychlorinated biphenyls (PCBs) as well as heavy metals Cr and Ni into the environment and groundwater, we decided to evaluate influence of the environmental contamination on eventual changes of genetic constitution of human body cells. The subjects analyzed were 36 phenotypically healthy newborn babies, who were born 12 months (n=22) and 18 months (n=14) after environmental contamination, and 25 newborns in 1998 as a control group...
January 2005: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/15174562/wear-debris-from-hip-or-knee-replacements-causes-chromosomal-damage-in-human-cells-in-tissue-culture
#15
B Daley, A T Doherty, B Fairman, C P Case
Wear debris was extracted from 21 worn hip and knee replacements. Its mutagenic effects were tested on human cells in tissue culture using the micronucleus assay and fluorescent in situ hybridisation. The extracted wear debris increased the level of micronuclei in a linear dose-dependent manner but with a tenfold difference between samples. The concentration of titanium +/- vanadium and aluminium within the wear debris was linearly related both to the level of centromere-positive micronuclei in tissue culture, indicating an aneuploid event, and to the level of aneuploidy in vivo in peripheral blood lymphocytes...
May 2004: Journal of Bone and Joint Surgery. British Volume
https://www.readbyqxmd.com/read/14681311/genotoxic-evaluation-of-welders-occupationally-exposed-to-chromium-and-nickel-using-the-comet-and-micronucleus-assays
#16
K Danadevi, Roya Rozati, B Saleha Banu, Paramjit Grover
Chromium (Cr) and nickel (Ni) are widely used industrial chemicals. Welders in India are inclined to possible occupational Cr and Ni exposure. The carcinogenic potential of metals is a major issue in defining human health risk from exposure. Hence, in the present investigation, 102 welders and an equal number of control subjects were monitored for DNA damage in blood leucocytes utilizing the Comet assay. The two groups had similar mean ages and smoking prevalences. A few subjects were randomly selected for estimation of Cr and Ni content in whole blood by inductively coupled plasma mass spectrometry...
January 2004: Mutagenesis
https://www.readbyqxmd.com/read/12712740/-content-of-metals-in-different-diameter-airborne-particles-and-effect-on-micronuclei-formation-in-human-lymphocytes
#17
F Yuan, Y Ma, Z Wu
Using a five stage sampling scheme, airborne particles were collected in a residential area of Taiyuan city. The contents of four metals, including Ni, Pb, Cd and Cr in different diameter airborne particles were determined by atomic absorption spectrophotometry. The mutagenicity of the extracts of airborne particles was investigated by means of Cytokinesis-blocking(CB) method. The results showed that the pollution of airborne particles in the residential area was very serious. The smaller the airborne particles are the more it contains metal elements...
January 30, 1999: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/12438003/assessment-of-cytogenetic-damage-in-lymphocytes-and-in-exfoliated-nasal-cells-of-dental-laboratory-technicians-exposed-to-chromium-cobalt-and-nickel
#18
Sema Burgaz, Gonca C Demircigil, Meltem Yilmazer, Nusret Ertaş, Yusuf Kemaloglu, Yavuz Burgaz
Dental laboratory technicians may be exposed to metal alloys that are used in the production of crowns, bridges and removable partial dentures. These alloys consist of 35-65% cobalt, 20-30% chromium, 0-30% nickel, and small amounts of molybdenum, silica, beryllium, boron and carbon. The aim of this study was to assess whether dental technicians are occupationally exposed to chromium, cobalt and nickel, by analyzing urinary excretion levels of these metals and to investigate the genotoxic effects of occupational exposure associated with dental prostheses production operations by analyzing cytokinesis-blocked micronucleus (CB-MN) frequencies in peripheral lymphocytes and micronucleus (MN) frequencies in exfoliated nasal cells from 27 dental laboratory technicians and 15 control subjects...
November 26, 2002: Mutation Research
https://www.readbyqxmd.com/read/11342235/genotoxic-ability-of-cadmium-chromium-and-nickel-salts-studied-by-kinetochore-staining-in-the-cytokinesis-blocked-micronucleus-assay
#19
COMPARATIVE STUDY
A I Seoane, F N Dulout
The aneugenic and clastogenic ability of cadmium chloride(II), cadmium sulfate(II), nickel chloride(II), nickel sulfate(II), chromium chloride(III) and potassium dichromate(IV) have been evaluated through kinetochore-stained micronucleus test. Traditional genotoxicity assays evaluate DNA damage, gene mutations and chromosome breakage. However, these tests are not adequate to detect aneugenic agents that do not act directly on DNA. Staining kinetochores in the cytokinesis-blocked micronucleus assay is a useful way to discriminate between clastogens and aneuploidogens and may allow a rapid identification of aneuploidy-inducing environmental compounds...
February 20, 2001: Mutation Research
https://www.readbyqxmd.com/read/9838054/mutagenicity-micronucleus-test-in-vicia-faba-root-tips-polycyclic-aromatic-hydrocarbons-and-heavy-metal-content-of-sediments-collected-in-tiber-river-and-its-tributaries-within-the-urban-area-of-rome
#20
S Minissi, D Caccese, F Passafiume, A Grella, C Eleonora, M Rizzoni
Sediments collected in Tiber river and in its main tributary water courses within the urban area of Rome were tested for mutagenicity by means of Vicia faba root tips micronucleus (MN) test. Representative samples were scored for micronucleus generating events (chromosome/chromatid loss and fragments) too. Sediments were assayed for content of the thirteen most important chemicals of polycyclic aromatic hydrocarbon (PAH) group and for some heavy metal ions (Cd, Cr, Cu, Ni, Pb, Zn). Samples were collected in four tributary rivers (Prima Porta, Acqua Traversa, Aniene and Magliana) just before their confluence with Tiber river and at different stations along the Tiber river itself upstream and downstream the sites of confluence of the sampled tributaries...
December 3, 1998: Mutation Research
keyword
keyword
118670
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"