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Elena Cela, Ana G Vélez, Alejandra Aguado, Gabriela Medín, José M Bellón, Cristina Beléndez
BACKGROUND AND OBJECTIVE: Sickle cell anaemia causes progressive organ damage. The objective is to describe school performance of patients with sickle cell anaemia and their clinical parameters and quality of life that may have an influence. The hypothesis is that if school alterations occur without other objective data, additional factors must be present besides the disease itself. PATIENTS AND METHODS: Transversal study performed in November 2015 considering analytical variables, complications and neuroradiological images of children with sickle cell anaemia, and family survey on school performance and quality of life...
December 16, 2016: Medicina Clínica
Abdullah Icli, Erkan Cure, Ali Ugur Uslu, Davut Sakiz, Medine Cumhur Cure, Miyase Ozucan, Rabia Aydogan Baykara, Ahmet Karakoyun, Sevket Balta, Cengiz Ozturk, Sevket Arslan, Adem Kucuk
Familial Mediterranean fever (FMF) is a disease characterized by chronic inflammation. Atherogenic index of plasma (AIP) is a logarithmic value of the triglyceride to high-density lipoprotein cholesterol ratio and it is a good marker for atherosclerotic heart disease and cardiac risk. In this study, we investigated subclinical atherosclerosis and cardiac risks in patients with FMF. Patients with FMF (78 men and 84 women) and healthy controls (74 men and 82 women) were included in this study. The AIP values of the patients were calculated and carotid intima-media thicknesses (cIMTs) were measured...
July 19, 2016: Angiology
Anine Christine Medin, Monica Hauger Carlsen, Lene Frost Andersen
OBJECTIVE: To validate estimated intakes of carotenoid-rich foods from a web-based food recall (WebFR) using carotenoids in blood as an objective reference method. DESIGN: Cross-sectional validation study using carotenoids in plasma to evaluate estimated intakes of selected carotenoid-rich foods. Participants recorded their food intake in the WebFR and plasma concentrations of β-carotene, α-carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin were measured...
December 2016: Public Health Nutrition
Megan Bang, Ananda Marin, Douglas Medin, Karen Washinawatok
This chapter describes a central tenet of Indigenous American social interaction, which emphasizes mutuality in collaboration and caring in Indigenous communities. This includes interactions with an agentive natural world, in which more-than-human beings act as participants in the lives of humans and vice versa. We argue that research on children's learning should take a broader view of interactional partners to include the natural world.
2015: Advances in Child Development and Behavior
Rukiye Unsal Sac, Medine Ayşin Taşar, İlknur Bostancı, Yurda Şimşek, Yıldız Bilge Dallar
The purpose of the study was to define characteristics of children with acute carbon monoxide poisoning. Eighty children hospitalized with acute carbon monoxide poisoning were recruited prospectively over a period of 12 months. Sociodemographic features, complaints and laboratory data were recorded. When the patient was discharged, necessary preventive measures to be taken were explained to parents. One month later, the parents were questioned during a control examination regarding the precautions that they took...
December 2015: Journal of Korean Medical Science
Anine Christine Medin, Helene Astrup, Britt Marlene Kåsin, Lene Frost Andersen
BACKGROUND: High-quality, Web-based dietary assessment tools for children are needed to reduce cost and improve user-friendliness when studying children's dietary practices. OBJECTIVE: To evaluate the first Web-based dietary assessment tool for children in Norway, the Web-based Food Record (WebFR), by comparing children's true school lunch intake with recordings in the WebFR, using direct unobtrusive observation as the reference method. METHODS: A total of 117 children, 8-9 years, from Bærum, Norway, were recruited from September to December 2013...
2015: Journal of Medical Internet Research
Hannah A Davies, Jillian Madine, David A Middleton
Aortic medial amyloid (AMA) is the most common localized human amyloid, occurring in virtually all of the Caucasian population over the age of 50. The main protein component of AMA, medin, readily assembles into amyloid-like fibrils in vitro. Despite the prevalence of AMA, little is known about the self-assembly mechanism of medin or the molecular architecture of the fibrils. The amino acid sequence of medin is strikingly similar to the sequence of the Alzheimer disease (AD) amyloid-β (Aβ) polypeptides around the structural turn region of Aβ, where mutations associated with familial, early onset AD, have been identified...
March 20, 2015: Journal of Biological Chemistry
Medine Kara, Oğuz Güçlü, Fevzi Sefa Dereköy, Mustafa Resorlu, Gürhan Adam
Background. Congenital absence of the submandibular gland (SMG) is a rare condition. Although complaints such as dry mouth, dental problems, or difficulty in swallowing may be seen, the subjects may also be asymptomatic. The absence of the SMG may be associated with hypertrophy of the contralateral SMG. Case Report. We report the case of a 44-year-old woman with incidentally detected left SMG aplasia, with contralateral SMG hypertrophy mimicking a mass, and the case of a 46-year-old woman with incidentally detected bilateral SMG aplasia, demonstrated by computerized tomography (CT) and magnetic resonance imaging (MRI)...
2014: Case Reports in Otolaryngology
Medine Yazici Güleç, Leman Ýnanç, Ömer Yanartaþ, Ahmet Üzer, Hüseyin Güleç
OBJECTIVE: Previous studies have shown that the ratio of suicide attempts is between 19.6 and 34.2% in patients with conversion disorder (CD), yet few studies have addressed this issue. The present study compared demographic and clinical variables and predictors of suicide attempts in patients with CD. METHODS: A total of 100 consecutive patients were recruited and divided into groups according to their history of suicide attempts. Socio-demographic variables such as economic status, age, gender, educational level, marital status, clinical variables such as the presence of psychiatric disorder in family, substance abuse, risky alcohol use, age of onset, subtype of CD, number of hospitalization were recorded...
April 2014: Comprehensive Psychiatry
Takeya Sato, Anton Neschadim, Arnon Lavie, Teruyuki Yanagisawa, Jeffrey A Medin
We previously described a novel suicide (or 'cell fate control') gene therapy enzyme/prodrug system based on an engineered variant of human thymidylate kinase (TMPK) that potentiates azidothymidine (AZT) activation. Delivery of a suicide gene sequence into tumors by lentiviral transduction embodies a cancer gene therapy that could employ bystander cell killing as a mechanism driving significant tumor regression in vivo. Here we present evidence of a significant bystander cell killing in vitro and in vivo mediated by the TMPK/AZT suicide gene axis that is reliant on the formation of functional gap-junctional intercellular communications (GJICs)...
2013: PloS One
Medine Gulluce, Furkan Orhan, Derya Yanmis, Tulin Arasoglu, Zuhal Guvenalp, Lutfiye Omur Demirezer
Mentha is a medicinal and aromatic plant belonging to the Lamiaceae family, which is widely used in food, flavor, cosmetic and pharmaceutical industries. Recently, it has been found that the use of Mentha as a pharmaceutical source is based on its phytochemical constituents that have far been identified as tannins, saponins, phenolic acids and flavonoids. This study was designed to evaluate the mutagenic and antimutagenic activities of apigenin 7-O-glucoside (A7G), a flavonoid isolated from Mentha longifolia (L...
September 2015: Toxicology and Industrial Health
Medine C Yilmaz, Serap Aksoylar, Durdane Erdogan, Bengu Demirag
Although central venous catheters (CVCs) have become an integral element of the care of patients undergoing hematopoietic stem cell transplantation (HSCT), the associated complications can lead to treatment delays and negatively affect the child and family's quality of life. The aim of this study was to identify the types, rate of, and risk factors for the complications relating to CVCs used in children undergoing HSCT in Turkey. One hundred children were followed prospectively to track catheter-related complications in the transplantation unit...
July 2012: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
Medine Gulluce, Furkan Orhan, Ahmet Adiguzel, Tugba Bal, Zuhal Guvenalp, Lutfiye Omur Dermirezer
Lamiaceae is an important plant family that has been investigated for its medicinal properties due to its large amounts of phenolic acids and flavonoids. Flavonoids have been shown to have antioxidant and antimutagenic activities in different test systems, but their certain mechanisms are still unclear. This study was designed to evaluate the mutagenic and antimutagenic activities of apigenin 7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp. longifolia. The possible antimutagenic potential of apigenin 7-O-rutinoside (A7R) was examined against mutagens ethyl methanesulfonate (EMS) and acridine (AC) in a eukaryotic cell system Saccharomyces cerevisiae RS112...
July 2013: Toxicology and Industrial Health
Esmina Avdibegović, Mevludin Hasanović, Medin Hodzić, Zihnet Selimbasić
In Central and Eastern European countries, after abandoning communism, significant political, economic and social changes occurred, followed by the increase in income inequality and social disparity. The goal of this study was to examine the relationship between psychological symptoms and monthly income of employees in companies undergoing privatization. The study included 258 workers from seven companies undergoing privatization in the Tuzla Canton region. For the study purposes, the Brief Symptom Inventory (BSI) and a general questionnaire with questions about socio-demographic characteristics, income, and workplace, were used...
December 2011: Collegium Antropologicum
Hanna Willander, Erik Hermansson, Jan Johansson, Jenny Presto
The BRICHOS domain was initially defined from sequence alignments of the Bri protein associated with familial dementia, chondromodulin associated with chondrosarcoma and surfactant protein C precursor (proSP-C) associated with respiratory distress syndrome and interstitial lung disease (ILD). Today BRICHOS has been found in 12 protein families. Mutations in the Bri2 and proSP-C genes result in familial dementia and ILD, respectively, and both these conditions are associated with amyloid formation. Amyloid is of great medical relevance as it is found in several major incurable diseases, like Alzheimer's and Parkinson's disease and diabetes mellitus...
October 2011: FEBS Journal
Makoto Yoshimitsu, Koji Higuchi, Masaaki Miyata, Sean Devine, Andre Mattman, Sandra Sirrs, Jeffrey A Medin, Chuwa Tei, Toshihiro Takenaka
BACKGROUND: Fabry disease is an X-linked lysosomal storage disorder caused by mutations of the α-galactosidase A (GLA) gene, and the disease is a relatively prevalent cause of left ventricular hypertrophy followed by conduction abnormalities and arrhythmias. Mutation analysis of the GLA gene is a valuable tool for accurate diagnosis of affected families. In this study, we carried out molecular studies of 10 unrelated families diagnosed with Fabry disease. MATERIALS AND METHODS: Genetic analysis of the GLA gene using conventional genomic sequencing was performed in 9 hemizygous males and 6 heterozygous females...
May 2011: Journal of Cardiology
Ilker Emin Medine, Perihan Unak, Serhan Sakarya, Feriha Toksöz
Human UDP-glucuronosyltransferases (UGTs) are a family of membrane-bound enzymes of the endoplasmic reticulum. They catalyze the glucuronidation of various endogenous and exogenous compounds, converting them into more polar glucuronides. In this study, uracil glucuronide was enzymatically synthesized using a UGT-rich microsome preparate, which was separated from Hutu-80 cells. Two different glucuronide derivatives were obtained, with a total reaction yield of 22.95% +/- 2.4% (n = 4). The glucuronide ligands were defined as uracil-n-glucuronide (UNG) and uracil-o-glucuronide (UOG)...
June 2010: Cancer Biotherapy & Radiopharmaceuticals
Ahmet Adiguzel, Hakan Ozer, Munevver Sokmen, Medine Gulluce, Atalay Sokmen, Hamdullah Kilic, Fikrettin Sahin, Ozlem Baris
Catnip (Nepeta cataria) is an important medicinal herb belonging to the mint family, Lamiaceae. In this study, the in vitro antimicrobial and antioxidant activities of the essential oil and methanol extract from Nepeta cataria, and its essential oil composition were investigated. The essential oil, which has 4aalpha,7alpha,7abeta-nepetalactone (70.4%), 4aalpha,7alpha,7abeta-nepetalactone (6.0%), thymol (2.3%), and 4aalpha,7alpha, 7abeta3-nepetalactone (2.5%), as main components, exhibited activity against eleven bacteria, and twelve fungi and a yeast, C...
2009: Polish Journal of Microbiology
Fraser Milton, Andy J Wills
Two free classification experiments that investigate the persistence of sort strategy are reported. Participants tend to persist with their initial categorization type (family resemblance or unidimensional) for the remaining sorts, overriding the effects of otherwise influential stimulus properties. Sort type was found to persist even after a one-week delay. Stimulus-driven models of free classification (e.g., the SUSTAIN model, [Love, B. C., Medin, D. L., & Gureckis, T. M. (2004). SUSTAIN: A network model of category learning...
February 2009: Acta Psychologica
Jennie Medin, Kerstin Ekberg, Anders Nordlund, Jörgen Eklund
AIMS: The objective of this pilot study was to explore whether organisational change and work-related stress, as measured by the Job Content Questionnaire, were associated with first-ever stroke among working people aged 30-65. METHODS: In a case-control study a total of 65 consecutive cases, aged 30-65 years of age, with first-ever stroke were recruited from four hospitals in Sweden during 2000-2002. During the same period, 103 random population controls in the same age interval were recruited...
2008: Work: a Journal of Prevention, Assessment, and Rehabilitation
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