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dengue thrombocytopenia

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https://www.readbyqxmd.com/read/28820720/dengue-virus-serotypes-1-and-2-responsible-for-major-dengue-outbreaks-in-nepal-clinical-laboratory-and-epidemiological-features
#1
Shyam Prakash Dumre, Renu Bhandari, Geeta Shakya, Sanjay Kumar Shrestha, Mahamoud Sama Cherif, Prakash Ghimire, Chonticha Klungthong, In-Kyu Yoon, Kenji Hirayama, Kesara Na-Bangchang, Stefan Fernandez
Dengue virus (DENV) is expanding toward previously nonendemic areas. DENV has recently been introduced in Nepal with limited information. We report the clinical features and serotype distribution of DENV in Nepal during the major outbreaks. A total of 1,215 clinical dengue cases at two major hospitals of central and western Nepal were investigated. Demographic, clinical, and laboratory parameters were recorded. Serum specimens were tested for DENV by IgM/IgG enzyme-linked immunosorbent assays (ELISAs) and reverse transcription polymerase chain reaction (RT-PCR)...
July 31, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28818105/severe-neutropenia-revealing-a-rare-presentation-of-dengue-fever-a-case-report
#2
J Shourick, A Dinh, M Matt, J Salomon, B Davido
BACKGROUND: Arboviruses are a common cause of fever in the returned traveler often associated with leucopenia, especially lymphopenia and thrombocytopenia. Transient neutropenia has been described in a few cases of arboviruses. However, prolonged and severe neutropenia (<500/mm(3)) has rarely been reported in dengue fever, especially in the returned traveler in Europe. CASE PRESENTATION: A 26-year-old healthy female without any medical past history, flying back from Thailand, presented a transient fever with severe neutropenia (<500/mm(3))...
August 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28765218/dengue-virus-infected-dendritic-cells-but-not-monocytes-activate-natural-killer-cells-through-a-contact-dependent-mechanism-involving-adhesion-molecules
#3
Vivian Vasconcelos Costa, Weijian Ye, Qingfeng Chen, Mauro Martins Teixeira, Peter Preiser, Eng Eong Ooi, Jianzhu Chen
Natural killer (NK) cells play a protective role against dengue virus (DENV) infection, but the cellular and molecular mechanisms are not fully understood. Using an optimized humanized mouse model, we show that human NK cells, through the secretion of gamma interferon (IFN-γ), are critical in the early defense against DENV infection. Depletion of NK cells or neutralization of IFN-γ leads to increased viremia and more severe thrombocytopenia and liver damage in humanized mice. In vitro studies using autologous human NK cells show that DENV-infected monocyte-derived dendritic cells (MDDCs), but not monocytes, activate NK cells in a contact-dependent manner, resulting in upregulation of CD69 and CD25 and secretion of IFN-γ...
August 1, 2017: MBio
https://www.readbyqxmd.com/read/28764747/dengue-specific-serotype-related-to-clinical-severity-during-the-2012-2013-epidemic-in-centre-of-brazil
#4
Benigno A M Rocha, Adriana O Guilarde, Angela F L T Argolo, Marianna Peres Tassara, Lucimeire A da Silveira, Isabela C Junqueira, Marília D Turchi, Valéria C R Féres, Celina M T Martelli
Please see Additional file 1 for translations of the abstract into the five official working languages of the United Nations. BACKGROUND: Currently, in Brazil, there is a co-circulation of the four dengue (DENV-1 to DENV-4) serotypes. This study aimed to assess whether different serotypes and antibody response patterns were associated with the severity of the disease during a dengue outbreak, which occurred in 2012/2013 in centre of Brazil. METHODS: We conducted a prospective study with 452 patients with laboratory confirmed dengue in central Brazil, from January 2012 to July 2013...
August 2, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28764157/seroepidemiology-of-spotted-fever-rickettsiosis-in-uttar-pradesh-a-prospective-study
#5
Chandra Dev Pati Tripathi, Mastan Singh, Jyotsna Agarwal, Chandra Kanta, Virendra Atam
INTRODUCTION: Spotted Fever Rickettsiosis (SFR), an acute febrile illness caused by Rickettsia rickettsii, R. conorii and R. akari which is associated with considerable morbidity and mortality. SFR is one of the most covert emerging infections of the present time which is prevalent in various parts of India as shown by the increase in the number of clinically diagnosed patients in various states except Uttar Pradesh. AIM: To diagnose SFR in clinically suspected patients using serological tests and recognition of common epidemiologic situations and clinical manifestations of SFR in the state of Uttar Pradesh...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28712817/clinical-features-and-dynamic-ordinary-laboratory-tests-differentiating-dengue-fever-from-other-febrile-illnesses-in-children
#6
Chih-Ho Chen, Yi-Chuan Huang, Kuang-Che Kuo, Chung-Chen Li
BACKGROUND: Dengue fever is not easily to be diagnosed before presentation of the classic symptoms. The study aimed to investigate the clinical features and dynamic laboratory tests in pediatric patients to facilitate dengue diagnosis. METHODS: This retrospective study examined the medical records of all pediatric patients who were clinically suspected to have dengue from June to December 2014. Laboratory-positive dengue cases were confirmed by detecting non-structural protein NS1, reverse transcription-polymerase chain reaction of dengue virus, and dengue-specific IgM seroconversion...
June 30, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28690377/dengue-symptoms-significance-in-anti-dengue-drug-development-road-less-travelled
#7
Anubrata Paul, Arpana Vibhuti
Dengue outbreak has affected rural areas of Delhi-NCR, Haryana widely but it lacks in surveillance. High cases of dengue symptoms were reported in these regions whereas dengue symptoms have been a neglected issue in the anti-dengue drug development. Therefore, this study aims to analyze the status of the dengue infection, a rural issue of Delhi-NCR, Haryana and to identify the significance of dengue symptoms in anti-dengue drug development. The study was conducted when there is high chance of dengue infection i...
2017: Bioinformation
https://www.readbyqxmd.com/read/28622093/suppressive-effect-of-dengue-virus-envelope-protein-domain-iii-on-megakaryopoiesis
#8
Guan-Ling Lin, Hsin-Hou Chang, Te-Sheng Lien, Po-Kong Chen, Hao Chan, Mei-Tzu Su, Chi-Yuan Liao, Der-Shan Sun
Dengue virus (DENV) infection can cause severe, life-threatening events, and no specific treatments of DENV infection are currently approved. Although thrombocytopenia is frequently observed in dengue patients, its pathogenesis is still not fully understood. Previous studies have suggested that DENV-induced thrombocytopenia occurs through viral-replication-mediated megakaryopoiesis inhibition in the bone marrow; however, the exact mechanism for megakaryopoiesis suppression remains elusive. In this study, a reductionist approach was applied, in which C57B/6J mice were inoculated with recombinant DENV-envelope protein domain III (DENV-EIII) instead of the full viral particle...
June 16, 2017: Virulence
https://www.readbyqxmd.com/read/28596655/a-correlation-of-the-platelet-count-with-d-dimer-levels-as-an-indicator-for-component-therapy-in-children-with-dengue-hemorrhagic-fever
#9
Arthi Sridhar, B M Sunil Kumar, Aarathi Rau, A T K Rau
Dengue Fever (DF) may evolve into two life threatening forms-Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). DHF is associated with increased vascular permeability and plasma leakage causing thrombocytopenia and loss of clotting factors into the third space and may result in bleeding initially due to thrombocytopenia and later due to disseminated intravascular coagulation (DIC), often as a terminal event. Prompt recognition and treatment of minor bleeds in DF children with incipient DIC with component therapy may be associated with improved survival while failure to do so is usually catastrophic...
June 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28539856/natural-regulatory-anticoagulants-proteins-among-sudanese-patients-with-dengue-virus-infection
#10
Bashir Abdrhman Bashir, Osman Khalaf Allah Saeed
THE COAGULATION SYSTEM: Abnormalities in natural physiologic anticoagulants are observed in dengue infection. Laboratory values such as protein C (PC), protein S (PS), and antithrombin (AT) indicate this problem on the coagulation system in dengue. Recently, an interrelationship between dengue and the levels of natural anticoagulants has been observed. OBJECTIVE: The study conducted to find out the effect of dengue on the natural anticoagulant proteins. METHODS: A case-control study was conducted in Port Sudan Teaching Hospital from February 2013 to June 2014 for 334 cases of dengue caused by dengue virus, 217 (65%) males and 117 (35%) were females along with 101 cases of control 64 (63...
April 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28518476/adult-onset-chronic-cyclic-thrombocytopenia-in-a-rhesus-macaque-macaca-mulatta-after-dengue-virus-vaccination-and-viral-challenge
#11
Galit H Frydman, Kelly A Metcalf Pate, Robert P Marini, Armelle M de Laforcade, Irene Bosch, Vasudevan Bakthavatchalu, Sureshkumar Muthupalani, Alton G Swennes, Claire E Lyons, Ronald G Tompkins, James G Fox
An 8-year-old, male Rhesus macaque (Macaca mulatta), previously used for dengue virus (DENV) vaccine research with viral challenge, was presented with adult-onset, chronic, cyclic thrombocytopenia. Platelet number, morphology, and function were evaluated by automated hematology, peripheral blood smears, electron microscopy, flow cytometry, and impedance aggregometry. Bone marrow was evaluated by cytology. Both serum anti-dengue nonstructural protein 1 (NS1) antibodies and anti-platelet antibodies were detected by ELISA...
June 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28504777/dengue-fever-with-compartment-syndrome-of-the-right-arm
#12
C Khoo, G Chu, M S Rosaida, S K Chidambaram
A 44-year-old woman was admitted to our hospital with dengue fever. She developed a haematoma in the right arm at the site of a previous arterial line insertion. Due to coexisting thrombocytopenia, the bleeding was severe enough to cause compartment syndrome. An emergency fasciotomy was performed and her limb salvaged. The case illustrates one important potential complication of this common infectious disease.
December 2016: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28491890/dengue-virus-entry-and-replication-does-not-lead-to-productive-infection-in-platelets
#13
Meenakshi Kar, Mohit Singla, Anmol Chandele, Sushil K Kabra, Rakesh Lodha, Guruprasad R Medigeshi
Thrombocytopenia is a characteristic feature during the acute phase of dengue infection and has been found to associate with vascular leakage in severe dengue. Although dengue antigens have been observed in platelets, there is no strong evidence to suggest a direct infection of platelets by dengue virus as a contributing factor for thrombocytopenia. We show that dengue virus can enter platelets but replicate viral ribonucleic acid to a minimal extent and, therefore, cannot produce infectious virus. Dengue antigen was undetectable in platelets isolated from dengue patients; however, we observed an increase in CD14(+)CD16(+) monocyte-platelet complexes, suggesting a mechanism for platelet clearance...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28475281/prolonged-viremia-in-dengue-virus-infection-in-hematopoietic-stem-cell-transplant-recipients-and-patients-with-hematological-malignancies
#14
Bárbara Brito de Souza Pereira, Luiz Guilherme Darrigo Junior, Thalita Cristina de Mello Costa, Alvina Clara Felix, Belinda P Simoes, Ana Beatriz Stracieri, Paula Moreira da Silva, Marcos Mauad, Clarisse M Machado
Fever, skin rash, headache, and thrombocytopenia are considered hallmarks of dengue infection. However, these symptoms are frequently observed in infectious and non-infectious complications of hematopoietic stem cell transplant recipients and oncohematological patients. Thus, laboratory confirmation of dengue is relevant for prompt intervention and proper management of dengue in endemic and non-endemic regions. Because no prospective study of dengue has been conducted in these populations, the actual morbidity and mortality of dengue is unknown...
August 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28448490/the-value-of-daily-platelet-counts-for-predicting-dengue-shock-syndrome-results-from-a-prospective-observational-study-of-2301-vietnamese-children-with-dengue
#15
Phung Khanh Lam, Tran Van Ngoc, Truong Thi Thu Thuy, Nguyen Thi Hong Van, Tran Thi Nhu Thuy, Dong Thi Hoai Tam, Nguyen Minh Dung, Nguyen Thi Hanh Tien, Nguyen Tan Thanh Kieu, Cameron Simmons, Bridget Wills, Marcel Wolbers
BACKGROUND: Dengue is the most important mosquito-borne viral infection to affect humans. Although it usually manifests as a self-limited febrile illness, complications may occur as the fever subsides. A systemic vascular leak syndrome that sometimes progresses to life-threatening hypovolaemic shock is the most serious complication seen in children, typically accompanied by haemoconcentration and thrombocytopenia. Robust evidence on risk factors, especially features present early in the illness course, for progression to dengue shock syndrome (DSS) is lacking...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28427358/cortical-laminar-necrosis-in-dengue-encephalitis-a-case-report
#16
Ravindra Kumar Garg, Imran Rizvi, Rajan Ingole, Amita Jain, Hardeep Singh Malhotra, Neeraj Kumar, Dhruv Batra
BACKGROUND: Dengue encephalitis is a rare neurological manifestation of dengue fever. Its clinical presentation is similar to other viral encephalitides and encephalopathy. No single specific finding on magnetic resonance imaging of dengue encephalitis has yet been documented. They are highly variable and atypical. CASE PRESENTATION: A 15-year boy presented with fever, the headache and altered sensorium of 12-day duration. On neurological examination, his Glasgow Coma Scale score was 10 (E3M4V3)...
April 20, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28403751/management-of-dengue-in-australian-travellers-a-retrospective-multicentre-analysis
#17
MULTICENTER STUDY
Alex Yc Tai, Sarah L McGuinness, Roselle Robosa, David Turner, G Khai Lin Huang, Karin Leder, Tony M Korman, Irani Thevarajan, Andrew J Stewardson, Alexander A Padiglione, Douglas F Johnson
OBJECTIVES: To describe the epidemiology, clinical and laboratory features and outcomes of dengue in returned Australian travellers, applying the revised WHO dengue classification (2009) to this population. DESIGN, SETTING AND PARTICIPANTS: Retrospective case series analysis of confirmed dengue cases hospitalised at one of four Australian tertiary hospitals, January 2012 - May 2015. MAIN OUTCOME MEASURES: Clinical features, laboratory findings and outcomes of patients with dengue; dengue classification according to 2009 WHO guidelines...
April 17, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28386493/dengue-and-scrub-typhus-coinfection-in-a-patient-presenting-with-febrile-illness
#18
Surendra Sapkota, Sudeep Bhandari, Subash Sapkota, Rabin Hamal
Dengue fever and scrub typhus are common causes of acute febrile illness of unclear origin in Asia. Though coinfections of many vector-borne diseases have been described, articles on dengue and scrub typhus coinfection are distinctly limited. In case of coinfection with dengue and scrub typhus, vigilant monitoring of vitals, platelets transfusion, and timely treatment with doxycycline are necessary. High degree of suspicion has to be made for coinfection in a patient presenting with febrile illness with thrombocytopenia and deranged laboratory parameters in postmonsoon season in endemic regions in Asia...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28367875/laboratory-and-molecular-characterization-of-dengue-virus-during-the-2014-outbreak-in-guangfo-region-southern-china
#19
Zhao-Fan Luo, Bo Hu, Feng-Yi Zhang, Xiang-Hua Lin, Xiao-Ying Xie, Kun-Yi Pan, Hong-Yu Li, Rui-Wen Ren, Wen-Zhong Zhao
Non-specific symptoms and low viremia levels make early diagnosis of dengue virus (DENV) infection challenging. This study aimed to 1) identify laboratory markers which can predict a positive laboratory diagnosis, and 2) perform a molecular characterization of DENV from the 2014 Guangdong epidemic. This retrospective study enrolled 1044 patients from the Guangdong epidemic who had clinically suspected dengue. Viral RNA was detected by real-time RT-PCR and viral-specific NS1 antigen was detected using ELISA...
March 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28287000/risk-factors-and-clinical-outcome-of-profound-thrombocytopenia-in-adult-patients-with-denv-infections
#20
Amreeta Dhanoa, Ganeswrie Rajasekaram, Sharifah Syed Hassan, Amutha Ramadas, Nur Amelia Azreen Adnan, Chun Fatt Lau, Teik Seng Chan, Chin Fang Ngim
Severe thrombocytopenia is common in dengue virus (DENV) infections. However, studies focusing on the role of profound thrombocytopenia (PT) (nadir platelet counts ≤ 20 000/mm(3)) in DENV infections are scarce. This study aims to identify the associated features and outcome of DENV patients with PT. It involves 237 adult hospitalized patients who were DENV PCR positive. The presence of comorbidity (AOR = 4.625; 95% CI = 1.113-19.230), higher admission hematocrit (AOR = 1.213; 95% CI = 1.067-1.379), lower admission albumin (AOR = 0...
March 13, 2017: Platelets
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