Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Maira Ludna Duarte, Aurylanne Mikaelle Brandão Silva, José Wellithom Viturino da Silva, Davi Pereira Santana, Whocely Victor de Castro, Luiz Cláudio Arraes de Alencar, Danilo César Galindo Bedor, Leila Bastos Leal
INTRODUCTION: The specific physiological background induced by pregnancy leads to significant changes in maternal pharmacokinetics, suggesting potential variability in plasma concentrations of antiretrovirals. Pregnant HIV patients exposed to subtherapeutic doses, particularly in the last trimester of the pregnancy, have higher chances to transmit the infection to their children. Therefore, the therapeutic drug monitoring of antiretrovirals in HIV pregnant patients would be of great value...
April 20, 2024: Clinical Biochemistry
#2
JOURNAL ARTICLE
Brianna N Natale, Rachel E Koffer, Samantha E Fairlie, Kristina D Dickman, Catherine P Walsh, Anna L Marsland, Thomas W Kamarck
OBJECTIVE: Childhood trauma may contribute to lifelong health through chronic systemic inflammation. However, associations between childhood trauma and inflammation are mixed, indicating that distinct types of childhood trauma may relate to inflammation differently. Moreover, most studies use a single assessment of inflammatory markers that may not reliably estimate stable interindividual differences. The current study is the first to examine relationships between childhood trauma and an ecologically valid measure of inflammation derived from repeated assessments of interleukin (IL)-6 in daily life...
April 22, 2024: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
#3
JOURNAL ARTICLE
Nimish Patel, Sheldon Morris, Leah Burke, Karen Chow, Deedee Pacheco, Peter Anderson, Frank Stancyzk, Jill Blumenthal
AIMS: Many transgender and gender diverse (TGD) individuals have expressed concerns about the potential for oral pre-exposure prophylaxis to affect hormonal concentrations achieved from taking gender-affirming hormone therapy (GAHT). The purpose of this study was to understand the bidirectional effects between hormone and intraerythrocytic tenofovir diphosphate concentrations when switching from tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) to tenofovir alafenamide/emtricitabine (TAF/FTC) in TGD users/nonusers of GAHT...
April 22, 2024: British Journal of Clinical Pharmacology
#4
Jennifer V Chavez, Leah Davis Ewart, Ozair Ilyas, Delaram Ghanooni, José E Diaz, Lindsay Atkins, Richard Ramos, Adriana Hernandez Garayua, Alex Stewart, Keith J Horvath, Sabina Hirshfield, Adam W Carrico
Background Sexual minority men (SMM) with HIV who use stimulants may experience greater difficulties with antiretroviral therapy adherence which amplifies risk for unsuppressed HIV viral load (VL). Remote monitoring of VL could support efforts to rapidly respond to sub-optimal adherence. Methods This qualitative study enrolled 24 SMM with HIV who use stimulants to examine experiences with two different dried blood spots (DBS) self-sampling devices (i.e., Tasso-M20 vs. HemaSpot HD) to measure VL. Participants were asked to complete self-sampling of DBS using both devices, and then participated in a 45-minute semi-structured interview...
April 2, 2024: Research Square
#5
JOURNAL ARTICLE
Masahiko Hachiya, Emilia Vynnycky, Yoshio Mori, Hung Thai Do, Mai Kim Huynh, Long Hoang Trinh, Duy Duc Nguyen, Nhu Anh Thi Tran, Thanh Tien Hoang, Hai Hang Thi Hoang, Ngoc Dieu Thi Vo, Thieu Hoang Le, Yasunori Ichimura, Shinsuke Miyano, Sumiyo Okawa, Moe Moe Thandar, Yuta Yokobori, Yosuke Inoue, Tetsuya Mizoue, Makoto Takeda, Kenichi Komada
BACKGROUND: Vietnam continues to have measles and rubella outbreaks following supplementary immunization activities (SIA) and routine immunization despite both having high reported coverage. To evaluate immunization activities, age-specific immunity against measles and rubella, and the number of averted Congenital Rubella Syndrome (CRS) cases, must be estimated. METHODS: Dried blood spots were collected from 2,091 randomly selected individuals aged 1-39 years. Measles and rubella virus-specific immunoglobulin G (IgG) were measured by enzyme immunoassay...
April 17, 2024: International Journal of Infectious Diseases: IJID
#6
JOURNAL ARTICLE
Lisanne M Geers, Anton J M Loonen, Daniël J Touw
BACKGROUND: Therapeutic drug monitoring (TDM) of antipsychotics for dose titration or detection of noncompliance is not uncommon in daily practice. Normally, TDM implies measuring a drug concentration in venous blood samples. This technique is invasive and requires trained assistants and patients normally need to go to an outpatient clinic. Over the past decades, sensitivity of analytical equipment has improved leading to a growing interest in microsampling techniques. These techniques are minimally invasive, require a small volume (<100 μL), usually result in stable samples, and can be collected by the patient or a caregiver at home...
April 19, 2024: Journal of Clinical Psychopharmacology
#7
JOURNAL ARTICLE
Karen Christina Walker, Sofie Gry Pristed, Fanney Thorsteinsdottir, Ina Olmer Specht, Arieh Cohen, Berit Lilienthal Heitmann, Ulrik Schiøler Kesmodel
INTRODUCTION: Sufficient levels of vitamin D have been associated with higher chances for both clinical pregnancy and live birth among women undergoing assisted reproductive techniques, whereas low levels of maternal vitamin D have been associated with preeclampsia and late miscarriage. In Denmark, subgroups at risk for low vitamin D levels, including neonates and toddlers, are recommended to use supplementation. The aim was to study the level of vitamin D3 among neonates born after in vitro fertilization compared with neonates from the general population...
April 18, 2024: Acta Obstetricia et Gynecologica Scandinavica
#8
JOURNAL ARTICLE
Ryan P Coyle, Mary Morrow, Sarah C Mann, Vincent Mainella, Samuel L Ellis, Stefanie Schwab, Corwin Coppinger, Nicholas Barker, Lucas Ellison, Jia-Hua Zheng, Subhi Al Zuabi, Pamela E Alpert, Tony C Carnes, D Eric Buffkin, Peter R Chai, Lane R Bushman, Jennifer J Kiser, Samantha MaWhinney, Kristina M Brooks, Peter L Anderson, Jose R Castillo-Mancilla
BACKGROUND: QUANTI-TAF aimed to establish tenofovir-diphosphate/emtricitabine-triphosphate (TFV-DP/FTC-TP) adherence benchmarks in dried blood spots (DBS) for persons with HIV (PWH) receiving tenofovir alafenamide/emtricitabine (TAF/FTC)-based antiretroviral therapy (ART). METHODS: During a 16-week pharmacokinetic study, PWH received TAF/FTC-based ART co-encapsulated with an ingestible sensor to directly measure cumulative (enrollment to final visit) and 10-day adherence...
April 18, 2024: Clinical Infectious Diseases
#9
JOURNAL ARTICLE
Silvia Ricci, Valentina Guarnieri, Francesca Capitanini, Caterina Pelosi, Valeria Astorino, Silvia Boscia, Elisa Calistri, Clementina Canessa, Martina Cortimiglia, Francesca Lippi, Lorenzo Lodi, Sabrina Malvagia, Maria Moriondo, Giancarlo La Marca, Chiara Azzari
BACKGROUND: Inborn errors of immunity (IEIs) include 485 inherited disorders characterized by an increased susceptibility to life threatening infectious diseases, autoimmunity and malignant diseases with a high mortality rate in the first years of life. Severe Combined Immunodeficiency is the most severe of the IEIs and its detection should be a primary goal in a newborn screening (NBS) program. The term "actionable" has recently been used for all IEIs with outcomes that can be demonstrably improved through early specialized intervention...
April 16, 2024: Journal of Allergy and Clinical Immunology in Practice
#10
JOURNAL ARTICLE
Geetika Narang, Jahnvi Jakhan, Suman Tamang, Karmveer Yadav, Vineeta Singh
One of the major challenges for malaria control and elimination is the spread and emergence of antimalarial drug resistance. Mutations in Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) field isolates for five drug resistance genes viz. crt, mdr1, dhps, dhfr and kelch known to confer resistance to choloroquine (CQ), sulfadoxine-pyrimethamine (SP) and artemisinin (ART) and its derivatives were analyzed. A total of 342 symptomatic isolates of P. falciparum (Pf) and P. vivax (Pv) from 1993 to 2014 were retrieved from malaria parasite repository at National Institute of Malaria Research (NIMR)...
April 16, 2024: Acta Tropica
#11
JOURNAL ARTICLE
Rafaela Caroline C Melo, Mauro C Ramos, Maria Lúcia R Rossetti, Vera Mileide T Grassi, Maurício O Colvero, Thales Augusto Dt Marzarotto, Renan R Bonamigo
INTRODUCTION: Congenital syphilis (CS) has severe adverse outcomes, including abortion and death. Diagnosis of CS in asymptomatic newborns remains difficult. This study aims to evaluate an in-house polymerase chain reaction (PCR) on cerebrospinal fluid (CSF) and blood samples (BS) to identify T. pallidum DNA in newborns. METHODOLOGY: We performed an exploratory cross-sectional study that included newborns exposed to syphilis during pregnancy (SEG) and non-exposed (SNEG) newborns, between 2019 and 2020...
March 31, 2024: Journal of Infection in Developing Countries
#12
JOURNAL ARTICLE
J Sebastian Garcia-Medina, Karolina Sienkiewicz, S Anand Narayanan, Eliah G Overbey, Kirill Grigorev, Krista A Ryon, Marissa Burke, Jacqueline Proszynski, Braden Tierney, Caleb M Schmidt, Nuria Mencia-Trinchant, Remi Klotz, Veronica Ortiz, Jonathan Foox, Christopher Chin, Deena Najjar, Irina Matei, Irenaeus Chan, Carlos Cruchaga, Ashley Kleinman, JangKeun Kim, Alexander Lucaci, Conor Loy, Omary Mzava, Iwijn De Vlaminck, Anvita Singaraju, Lynn E Taylor, Julian C Schmidt, Michael A Schmidt, Kelly Blease, Juan Moreno, Andrew Boddicker, Junhua Zhao, Bryan Lajoie, Andrew Altomare, Semyon Kruglyak, Shawn Levy, Min Yu, Duane C Hassane, Susan M Bailey, Kelly Bolton, Jaime Mateus, Christopher E Mason
BACKGROUND: The Inspiration4 (I4) mission, the first all-civilian orbital flight mission, investigated the physiological effects of short-duration spaceflight through a multi-omic approach. Despite advances, there remains much to learn about human adaptation to spaceflight's unique challenges, including microgravity, immune system perturbations, and radiation exposure. METHODS: To provide a detailed genetics analysis of the mission, we collected dried blood spots pre-, during, and post-flight for DNA extraction...
March 2024: Precision Clinical Medicine
#13
Kamil A Braima, Kim A Piera, Inke Nd Lubis, Rintis Noviyanti, Giri S Rajahram, Pinkan Kariodimedjo, Irbah Ra Nainggolan, Ranti Permatasari, Leily Trianty, Ristya Amalia, Sitti Saimah Binti Sakam, Angelica F Tan, Timothy William, Jacob Af Westaway, PingChin Lee, Sylvia Daim, Henry Surendra, Nathaniel Christy, Andrew G Letizia, Christopher L Peatey, Mohd Arshil Moideen, Bridget E Barber, Colin J Sutherland, Nicholas M Anstey, Matthew J Grigg
BACKGROUND: Zoonotic P. knowlesi and P. cynomolgi symptomatic and asymptomatic infections occur across endemic areas of Southeast Asia. Most infections are low-parasitemia, with an unknown proportion below routine microscopy detection thresholds. Molecular surveillance tools optimizing the limit of detection (LOD) would allow more accurate estimates of zoonotic malaria prevalence. METHODS: An established ultra-sensitive Plasmodium genus quantitative-PCR (qPCR) assay targeting the 18S rRNA gene underwent LOD evaluation with and without reverse transcription (RT) for P...
April 6, 2024: medRxiv
#14
JOURNAL ARTICLE
Sarah Rocha, Julienne E Bower, Jessica J Chiang, Steve W Cole, Michael R Irwin, Teresa Seeman, Andrew J Fuligni
The objective of the present study was to evaluate the interdependency of parent-adolescent inflammation trends across time and to examine whether shared family socioeconomic characteristics explained between-family differences in parents' and adolescents' risk for inflammation. A total of N = 348 families, consisting of one parent and one adolescent child, were followed every two years in a three-wave longitudinal study. Sociodemographic questionnaires were used to determine parental educational attainment and family income-to-needs ratio (INR)...
July 2024: Brain, behavior, & immunity health
#15
JOURNAL ARTICLE
Bacha Mekonen, Sisay Dugassa, Sindew Mekasha Feleke, Boja Dufera, Bedasa Gidisa, Aderaw Adamu, Aynalem Mandefro, Geremew Tasew, Lemu Golassa
BACKGROUND: Rapid diagnostic tests (RDTs) play a significant role in expanding case management in peripheral healthcare systems. Histidine-rich protein-2 (HRP2) antigen detection RDTs are predominantly used to diagnose Plasmodium falciparum infection. However, the evolution and spread of P. falciparum parasite strains with deleted hrp2/3 genes, causing false-negative results, have been reported. This study assessed the diagnostic performance of HRP2-detecting RDTs for P. falciparum cases and the prevalence of pfhrp2/3 deletions among symptomatic patients seeking malaria diagnosis at selected health facilities in southern Ethiopia...
April 17, 2024: Malaria Journal
#16
JOURNAL ARTICLE
Vanessa M McMahan, Dana L Atkins, Smitty Buckler, Lauren R Violette, Lisa Niemann, Noah Frank, Kimiam Waters, Luis Enrique Herrera Perales, Luis Viquez, Elyse Tung, Joanne D Stekler
BACKGROUND: Methamphetamine is associated with increased HIV risk and suboptimal adherence to pre-exposure prophylaxis (PrEP). Interventions to support PrEP adherence for people who use methamphetamine are needed. METHODS: We evaluated peer navigation to support adherence among people initiating PrEP who use methamphetamine. The <u>H</u>IV Prevention in <u>M</u>ethamphetamine <u>U</u>sers (HMU!) study enrolled participants from May 2018-January 2022 in Seattle, WA, and followed them for 6 months...
April 17, 2024: International Journal of STD & AIDS
#17
JOURNAL ARTICLE
Christopher James, Cory W Dugan, Corrin Boyd, Paul A Fournier, Peter G Arthur
PURPOSE: Exercise-induced muscle damage (EIMD) results in the generation of reactive oxygen species (ROS), but little is known about the temporal profile of change in ROS post-EIMD and how ROS levels relate to the onset of and recovery from EIMD. Our primary aim was to examine the effect of EIMD on the pattern of change in the blood level of thiol-oxidised albumin, a marker of oxidative stress. METHODS: Seven male participants were subjected on separate days to eccentric muscle contraction to cause EIMD or a no-exercise condition...
April 16, 2024: European Journal of Applied Physiology
#18
JOURNAL ARTICLE
Dawn M E Bowdish, Vinod Chandran, Carol A Hitchon, Gilaad G Kaplan, J Antonio Avina-Zubieta, Paul R Fortin, Maggie J Larché, Gilles Boire, Anne-Claude Gingras, Roya M Dayam, Ines Colmegna, Luck Lukusa, Jennifer L F Lee, Dawn P Richards, Daniel Pereira, Tania H Watts, Mark S Silverberg, Charles N Bernstein, Diane Lacaille, Jenna Benoit, John Kim, Nadine Lalonde, Janet Gunderson, Hugues Allard-Chamard, Sophie Roux, Joshua Quan, Lindsay Hracs, Elizabeth Turnbull, Valeria Valerio, Sasha Bernatsky
OBJECTIVE: To determine how serologic responses to COVID vaccination/infection in immunemediated inflammatory disease (IMID) are affected by time since last vaccination and other factors. METHODS: Post-COVID-19 vaccination, data and dried blood spots/sera were collected from adults with rheumatoid arthritis, inflammatory bowel disease, systemic lupus, ankylosing spondylitis/spondylarthritis and psoriasis/psoriatic arthritis. First sample was at enrolment and then 2-4 weeks and 3, 6, and 12 months after latest vaccine dose...
April 15, 2024: Journal of Rheumatology
#19
JOURNAL ARTICLE
Paula S Tallman, Aaron A Miller, Sophea R Brandley, Cassie C Lee, Tara J Cepon-Robins, Theresa E Gildner, Shalean M Collins
OBJECTIVES: Helicobacter pylori (H. pylori)-a gastric bacteria affecting almost 50% of the global population and leading to ulcers and cancer in severe cases-is a growing health concern among Indigenous populations who report a high burden of reported poor general health and gastrointestinal distress. We test hypothesized associations between H. pylori exposure patterns and environmental, social, and biological conditions among a sample of 212 Indigenous Awajún adults (112 males, 100 females, ages 18-65 years) living in the northern Peruvian Amazon...
April 13, 2024: American journal of biological anthropology
#20
JOURNAL ARTICLE
Bronwyn Neufeld, Chantal Munyuza, Alexandria Reimer, Rupert Capiña, Emma R Lee, Marissa Becker, Paul Sandstrom, Hezhao Ji, François Cholette
Despite increasing scale-up of antiretroviral therapy (ART) coverage, challenges related to adherence and HIV drug resistance (HIVDR) remain. The high cost of HIVDR surveillance is a persistent challenge with implementation in resource-constrained settings. Dried blood spot (DBS) specimens have been demonstrated to be a feasible alternative to plasma or serum for HIVDR genotyping and are more suitable for lower resource settings. There is a need for affordable HIVDR genotyping assays which can amplify HIV-1 sequences from DBS specimens, particularly those with low viral loads, at a low cost...
April 9, 2024: Journal of Virological Methods
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
