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https://www.readbyqxmd.com/read/27861155/new-conception-for-the-development-of-hypertension-in-preeclampsia
#1
Qinqin Gao, Jiaqi Tang, Na Li, Xiuwen Zhou, Xiaolin Zhu, Weisheng Li, Bailin Liu, Xueqin Feng, Jianying Tao, Bing Han, Hong Zhang, Miao Sun, Zhice Xu
Placental vascular dysfunction was suggested to be critical for placental ischemia-initiated hypertension in preeclampsia, although the contributions of endothelium involved are unclear. The present study found, unlike non-placental vessels, acetylcholine showed no vasodilatation effect on placental vessels, indicating that endothelial-derived nitric oxide (NO) was extremely weak in placental vessels. Placental vascular responses to exogenous NO from sodium nitroprusside (SNP) were significantly different from non-placental vessels...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27856999/simvastatin-alleviates-pathology-in-a-rat-model-of-preeclampsia-involving-erk-mapk-pathway
#2
Xiujuan Dong, Dandan Shi
Preeclampsia (PE) is a pregnancy-specific condition characterized by new-onset hypertension. There is evidence suggesting that imbalances of angiogenic factors, oxidative stress, and inflammation may be central to the pathogenesis of PE. We sought to investigate whether simvastatin would reduce mean arterial pressure, restore the angiogenic balance, and ameliorate inflammation and oxidative stress in a nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester (l-NAME)-induced rat model of PE. We found that blood pressure was significantly increased in the l-NAME group compared to normal pregnant dams (P < ...
November 16, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27815419/altered-hippocampal-arteriole-structure-and-function-in-a-rat-model-of-preeclampsia-potential-role-in-impaired-seizure-induced-hyperemia
#3
Abbie C Johnson, Marilyn J Cipolla
We investigated the effect of experimental preeclampsia on hyperemia during seizure in the hippocampus and vascular function and structure of hippocampal arterioles using Sprague Dawley rats (n = 14/group) that were nonpregnant, pregnant (d20), or had experimental preeclampsia (induced by a high cholesterol diet d7-20). Hyperemia was measured via hydrogen clearance basally and during pentylenetetrazol-induced seizure (40-130 mg/kg i.v.). Reactivity of isolated and pressurized hippocampal arterioles to KCl, nitric oxide synthase inhibition with NG-nitro-L-arginine methyl ester and the nitric oxide donor sodium nitroprusside were investigated...
November 4, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27791173/prolactin-alters-blood-pressure-by-modulating-the-activity-of-endothelial-nitric-oxide-synthase
#4
Albert S Chang, Ruriko Grant, Hirofumi Tomita, Hyung-Suk Kim, Oliver Smithies, Masao Kakoki
Increased levels of a cleaved form of prolactin (molecular weight 16 kDa) have been associated with preeclampsia. To study the effects of prolactin on blood pressure (BP), we generated male mice with a single-copy transgene (Tg; inserted into the hypoxanthine-guanine phosphoribosyltransferase locus) that enables inducible hepatic production of prolactin and its cleavage product. The Tg is driven by the indole-3-carbinol (I3C)-inducible rat cytochrome P450 1A1 promoter. When the Tg mice were fed normal chow (NC), plasma prolactin concentrations were comparable to those in female WT mice in the last third of pregnancy, and BP was lower than in WT mice (∼95 mm Hg vs...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27754163/sy-11-3-hypertension-in-women-more-dangerous-than-in-men
#5
Suzanne Oparil
Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. In the US between 2011-2014, the prevalence of hypertension in women and men by age group was 6% vs 8% (18-39 years), 30% vs 35% (40-59 years), and 67% vs 63% (60 years and over). Awareness, treatment, and control rates differ between genders with women being more aware of their diagnosis (85% vs 80%), more likely to take their medications (81% vs 71%) and more frequently having controlled hypertension (55% vs 49%)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27680811/f5-skin-microvascular-dysfunction-in-preeclampsia-persists-to-the-postpartum-period
#6
Melanie Wittwer, Yann York Chow, Gus Dekker, Vicki Clifton, Margaret Arstall
INTRODUCTION: Preeclampsia is a multisystem disorder characterised by endothelial and microvascular dysfunction that develops in ∼10% of pregnancies. This study will characterise skin microvascular reactivity using laser Doppler flowmetry in women with preeclampsia compared to matched controls during pregnancy and early postpartum. METHODS: Women were recruited and studied on the diagnosis of preeclampsia and followed up for 6-months during postpartum period. Controls were matched for age, gestation and comorbidities...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27629886/serelaxin-improves-the-pathophysiology-of-placental-ischemia-in-the-reduced-uterine-perfusion-pressure-rat-model-of-preeclampsia
#7
Jose A Santiago-Font, Lorena M Amaral, Jessica Faulkner, Tarek Ibrahim, Venkata Ramana Vaka, Mark W Cunningham, Babbette LaMarca
Preeclampsia is a hypertensive disorder of pregnancy that has limited therapeutic options. In healthy pregnancy, relaxin plays an important vasodilatory role to maintain vascular compliance; however, currently, there is no preclinical evidence to support the use of relaxin during preeclampsia. Therefore, the goal of this study was to test the hypothesis that recombinant human relaxin-2 (Serelaxin, Novartis; RLX) could reduce mean arterial pressure (MAP) and improve uterine artery resistance index (UARI) and nitric oxide bioavailability, and/or decrease prepro-endothelin-1 (PPET-1), soluble fms-like tyrosine kinase-1 (sFlt-1), and TNF-α) in the reduced uterine perfusion pressure (RUPP) model of preeclampsia...
December 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27583470/adrenomedullin2-adm2-intermedin-imd-a-potential-role-in-the-pathophysiology-of-preeclampsia
#8
Madhu Chauhan, Meena Balakrishnan, Alex Vidaeff, Uma Yallampalli, Fernando Lugo, Karin Fox, Michael Belfort, Chandra Yallampalli
CONTEXT: It is not known whether decreases in trophoblast invasion promoting the peptide, adrenomedullin2 (ADM2) system is associated with preeclampsia (PreE). OBJECTIVE: The objective of the study was to assess the changes in ADM2 levels in plasma, placenta, and amniotic fluid (AF) and its receptor components in placenta from PreE pregnancy compared with the age-matched normal and study the effect of ADM2 on the synthesis of nitric oxide (NO), endothelial nitric oxide synthase (eNOS), and matrix-metalloproteinase (MMP)-2 and MMP-9 in trophoblast cells...
November 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27533763/inflammatory-and-oxidative-stress-airway-markers-in-premature-newborns-of-hypertensive-mothers
#9
R J Madoglio, L M S S Rugolo, C S Kurokawa, M P A Sá, J C Lyra, L C O Antunes
Although oxidative stress and inflammation are important mechanisms in the pathophysiology of preeclampsia and preterm diseases, their contribution to the respiratory prognosis of premature infants of hypertensive mothers is not known. Our objective was to determine the levels of oxidative stress and inflammation markers in the airways of premature infants born to hypertensive and normotensive mothers, in the first 72 h of life, and to investigate whether they are predictors of bronchopulmonary dysplasia (BPD)/death...
August 1, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27484589/astaxanthin-blocks-preeclampsia-progression-by-suppressing-oxidative-stress-and-inflammation
#10
Rong-Rong Xuan, Ting-Ting Niu, Hai-Min Chen
To investigate the antioxidative effect of astaxanthin on Nω-nitro-L-arginine methyl ester (L-NAME)-induced preeclamptic rats. Cell survival, the level of reactive oxygen species (ROS) and the changes in mitochondrial membrane potential (MMP) were examined in astaxanthin and H2O2-treated human umbilical vein endothelial cells (HUVECs). The preeclamptic Sprague-Dawley (SD) rat model was established by injection of L‑NAME and treatment with astaxanthin. The activities of malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide synthase (NOS) in serum were analyzed...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27451103/mechanisms-of-endothelial-dysfunction-in-hypertensive-pregnancy-and-preeclampsia
#11
J S Possomato-Vieira, R A Khalil
Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead to maternal and fetal morbidity and mortality. Although the causative factors and pathophysiological mechanisms are unclear, endothelial dysfunction is a major hallmark of preeclampsia. Clinical tests and experimental research have suggested that generalized endotheliosis in the systemic, renal, cerebral, and hepatic circulation could decrease endothelium-derived vasodilators such as nitric oxide, prostacyclin, and hyperpolarization factor and increase vasoconstrictors such as endothelin-1 and thromboxane A2, leading to increased vasoconstriction, hypertension, and other manifestation of preeclampsia...
2016: Advances in Pharmacology
https://www.readbyqxmd.com/read/27270170/soluble-fms-like-tyrosine-kinase-1-promotes-angiotensin-ii-sensitivity-in-preeclampsia
#12
Suzanne D Burke, Zsuzsanna K Zsengellér, Eliyahu V Khankin, Agnes S Lo, Augustine Rajakumar, Jennifer J DuPont, Amy McCurley, Mary E Moss, Dongsheng Zhang, Christopher D Clark, Alice Wang, Ellen W Seely, Peter M Kang, Isaac E Stillman, Iris Z Jaffe, S Ananth Karumanchi
Preeclampsia is a hypertensive disorder of pregnancy in which patients develop profound sensitivity to vasopressors, such as angiotensin II, and is associated with substantial morbidity for the mother and fetus. Enhanced vasoconstrictor sensitivity and elevations in soluble fms-like tyrosine kinase 1 (sFLT1), a circulating antiangiogenic protein, precede clinical signs and symptoms of preeclampsia. Here, we report that overexpression of sFlt1 in pregnant mice induced angiotensin II sensitivity and hypertension by impairing endothelial nitric oxide synthase (eNOS) phosphorylation and promoting oxidative stress in the vasculature...
July 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27251093/n-acetylcysteine-prevents-programmed-hypertension-in-male-rat-offspring-born-to-suramin-treated-mothers
#13
You-Lin Tain, Chien-Ning Hsu, Chien-Te Lee, Yu-Ju Lin, Ching-Chou Tsai
Adulthood hypertension can be programmed by preeclampsia. Preeclampsia is associated with an imbalance in vasoactive factors, including nitric oxide (NO), hydrogen sulfide (H2S), and renin-angiotensin system (RAS). We examined whether maternal N-acetylcysteine (NAC) therapy prevented maternal suramin treatment-induced programmed hypertension in offspring and explored the effects of this therapy on NO, H2S, and RAS pathways in the kidneys. Pregnant Sprague-Dawley rats were intraperitoneally administered 60 mg/kg suramin alone on Gestational Days 10 and 11 and were treated with or without 1% NAC through drinking water during the entire pregnancy and lactation period...
July 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27181106/sodium-nitrite-attenuates-hypertension-in-pregnancy-and-blunts-increases-in-soluble-fms-like-tyrosine-kinase-1-and-in-vascular-endothelial-growth-factor
#14
Victor Hugo Gonçalves-Rizzi, Jose Sergio Possomato-Vieira, Tamiris Uracs Sales Graça, Regina Aparecida Nascimento, Carlos A Dias-Junior
Preeclampsia is a pregnancy-associated disorder characterized by hypertension with uncertain pathogenesis. Increases in antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt-1) and reductions in nitric oxide (NO) bioavailability have been observed in preeclamptic women. However, the specific mechanisms linking these detrimental changes to the hypertension-in-pregnancy are not clearly understood. In this regard, while recent findings have suggested that nitrite-derived NO formation exerts antihypertensive and antioxidant effects, no previous study has examined these responses to orally administered nitrite in hypertension-in-pregnancy...
July 1, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27110515/allele-genotype-and-haplotype-structures-of-functional-polymorphic-variants-in-endothelial-nitric-oxide-synthase-enos-angiotensinogen-ace-and-aldosterone-synthase-cyp11b2-genes-in-healthy-pregnant-women-of-indian-ethnicity
#15
Anichavezhi Devendran, Sreekala Nampoothiri, Deepak Gopal Shewade, Suvro Chatterjee, Balachandar Jayaraman, Adithan Chandrasekharan
BACKGROUND: Variants in the candidate genes eNOS, CYP11B2 and ACE have been implicated as liable biomarkers that can predict complications like hypertension and preeclampsia. Studies on the impact and distribution of these variants on healthy pregnancy have not been done so far in south Indian or in any of the native Indian population. Examining these variants could lay a strong basis in understanding the genetic aspects of preeclampsia and further offer effective means in early risk assessment in a preeclampsia...
October 2015: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/27094609/preeclampsia-updates-in-pathogenesis-definitions-and-guidelines
#16
REVIEW
Elizabeth Phipps, Devika Prasanna, Wunnie Brima, Belinda Jim
Preeclampsia is becoming an increasingly common diagnosis in the developed world and remains a high cause of maternal and fetal morbidity and mortality in the developing world. Delay in childbearing in the developed world feeds into the risk factors associated with preeclampsia, which include older maternal age, obesity, and/or vascular diseases. Inadequate prenatal care partially explains the persistent high prevalence in the developing world. In this review, we begin by presenting the most recent concepts in the pathogenesis of preeclampsia...
June 6, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27059075/impaired-sodium-dependent-adaptation-of-arterial-stiffness-in-formerly-preeclamptic-women-the-retap-vascular-study
#17
Anne Marijn van der Graaf, Nina D Paauw, Tsjitske J Toering, Martin Feelisch, Marijke M Faas, Thomas R Sutton, Magdalena Minnion, Joop D Lefrandt, Sicco A Scherjon, Arie Franx, Gerjan Navis, A Titia Lely
Women with a history of preeclampsia have an increased risk for cardiovascular diseases later in life. Persistent vascular alterations in the postpartum period might contribute to this increased risk. The current study assessed arterial stiffness under low sodium (LS) and high sodium (HS) conditions in a well-characterized group of formerly early-onset preeclamptic (fPE) women and formerly pregnant (fHP) women. Eighteen fHP and 18 fPE women were studied at an average of 5 yr after pregnancy on 1 wk of LS (50 mmol Na(+)/day) and 1 wk of HS (200 mmol Na(+)/day) intake...
June 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27030287/enos-inos-and-endoplasmic-reticulum-stress-induced-apoptosis-in-the-placentas-of-patients-with-preeclampsia
#18
L Du, F He, L Kuang, W Tang, Y Li, D Chen
Disruption of nitric oxide pathway and endoplasmic reticulum (ER) stress had been observed in preeclampsia (PE). However, the correlation and overall detailed expression profiles of ER stress-related markers and endothelial nitric oxide synthase/inducible nitric oxide synthase (eNOS/iNOS) in patients with PE were poorly understood. In this study, placental protein expression of ER stress-related markers as well as eNOS/iNOS in normotensive control (n=32) and PE pregnancies (n=32) was examined by western blot...
March 31, 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/27013262/-can-we-prevent-preeclampsia
#19
Louise Ghesquière, Elodie Clouqueur, Charles Garabedian, Vassili Tsatsaris, Veronique Houfflin-Debarge
Preeclampsia (PE), a specific complication of pregnancy, is one of the most frequent causes of maternal and fetal morbidity and mortality in the world. Recently, PE risk calculation algorithms allowing early detection of PE in the first trimester of pregnancy have been described. The aim of early detection would be to rapidly introduce an effective preventive treatment. The aim of our work is to study the different preventive treatments through the literature. Aspirin has some efficiency and reduces the risk of PE from 10 to 24%...
April 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27003519/serum-nitrate-and-nox-levels-in-preeclampsia-are-higher-than-in-normal-pregnancy
#20
Breno José Acauan Filho, Bartira Ercilia Pinheiro da Costa, Patrícia Barcelos Ogando, Matias Costa Vieira, Ivan Carlos Antonello, Carlos Eduardo Poli-de-Figueiredo
OBJECTIVES: To compare nitric oxide (NO) serum levels in women with and without preeclampsia. METHODS: 106 women were classified into preeclampsia group (n = 40) and normotensive group (n = 66). NO content was measured in the serum. Clinical and laboratorial data were recorded for comparison. RESULTS: Preeclampsia presented a significant increase in nitrate and NOx levels compared to the control group. Uric acid, gestational age, systolic and diastolic blood pressure, and creatinine showed correlation with nitrates and NOx...
May 2016: Hypertension in Pregnancy
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