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https://www.readbyqxmd.com/read/29739273/angiogenic-dysregulation-in-pregnancy-related-hypertension-a-role-for-metformin
#1
Nerolen Soobryan, Saravanakumar Murugesan, Arunagiri Pandiyan, Jagidesa Moodley, Irene Mackraj
In the face of escalating maternal and fetal health threats, hypertensive pregnancy disorders (HPDs) is one of the leading cause of maternal and fetal morbidity and mortality. The range of HPDs include white-coat hypertension, chronic hypertension, gestational hypertension, mild-to-moderate and severe preeclampsia and eclampsia. Current evidence implicates an imbalance of circulating anti- and angiogenic factors in HPDs emanating from the placental vasculature, impacting on angiogenesis. Delivery of the fetus is thus far the only curative measure, albeit with increased risk...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29716747/mechanisms-of-the-effect-of-magnesium-salts-in-preeclampsia
#2
Delia I Chiarello, Reinaldo Marín, Fulgencio Proverbio, Paula Coronado, Fernando Toledo, Rocio Salsoso, Jaime Gutiérrez, Luis Sobrevia
Preeclampsia is a heterogeneous pregnancy-specific syndrome associated with abnormal trophoblast invasion and endothelial dysfunction. Magnesium (Mg2+ ) level may be normal or decreased in women with preeclampsia. However, the use of Mg2+ salts, such as Mg2+ sulphate, are useful in reducing the pathophysiological consequences of preeclampsia with severe features and eclampsia. Although the mechanism of action of this Mg2+ salt is not well understood, the available evidence suggests a beneficial effect of Mg2+ for the mother and foetus...
April 24, 2018: Placenta
https://www.readbyqxmd.com/read/29673971/changes-in-trophoblasts-gene-expression-in-response-to-perchlorate-exposition
#3
De la Peña Sol, Santiago-Roque Isela, Olivo-Vidal Zendy, Navarro-Meza Mónica, Xochihua-Rosas Irene, Arroyo-Helguera Omar
Contaminated water with chlorates is a public health problem associated with iodine deficiency. Epidemiological evidence shows that iodine deficiency is a risk factor for preeclampsia (PE). In this study we use human BeWo trophoblast cells exposed to perchlorate (KClO4 ) and changes in gene expression were analyzed by microarrays, quantitative RT-PCR (qRT-PCR) and immunoblot. The microarray analysis identified 48 transcripts up-regulated and 112 down-regulated in comparison with non-exposed trophoblast. The qRT-PCR analysis confirmed changes in GAS7, PKP2, Emilin, Dynatic 3, protocadherins 11, 15, gamma A12, EGFR, SAFB1, ACE2, ANXA2, Apoliprotein E, SREBF1, and C/EBP-β...
April 16, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29629873/a-maternally-sequestered-biopolymer-stabilized-vascular-endothelial-growth-factor-vegf-chimera-for-treatment-of-preeclampsia
#4
Omar C Logue, Fakhri Mahdi, Heather Chapman, Eric M George, Gene L Bidwell
BACKGROUND: Preeclampsia is a hypertensive syndrome that complicates 3% to 5% of pregnancies in the United States. Preeclampsia originates from an improperly vascularized and ischemic placenta that releases factors that drive systemic pathophysiology. One of these factors, soluble fms-like tyrosine kinase-1, is believed to sequester vascular endothelial growth factor (VEGF), leading to systemic endothelial dysfunction and hypertension. With the goal of targeting soluble fms-like tyrosine kinase-1 while simultaneously preventing fetal exposure to VEGF, we fused VEGF to elastin-like polypeptide, a biopolymer carrier that does not cross the placental barrier (ELP-VEGF)...
December 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29548823/arginase-controls-soluble-vascular-endothelial-growth-factor-receptor-1-flt1-to-maintain-pregnancy-homeostasis
#5
Hiroko Tanaka, Keiichi Kumasawa, Aiko Kakigano, Kazuya Mimura, Masayuki Endo, Takuji Tomimatsu, Tadashi Kimura
Excessive soluble fms-like tyrosine kinase-1 (sFlt-1) has been strongly implicated in preeclampsia. An increase in the serum sFlt-1 level occurs before the onset of preeclampsia, and the sFlt-1 level is already higher in women who are predisposed to preeclampsia than in normotensive pregnant women. This study aimed to investigate the relation between arginase and sFlt-1 in the plasma of preeclamptic women and normotensive pregnant women. We suggested that a regulatory mechanism exists that suppresses the level of sFlt-1...
March 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29523272/nitrate-rich-dietary-supplementation-during-pregnancy-the-pros-and-cons
#6
Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi, Asghar Ghasemi
Inorganic nitrate (NO3 ) due to its potential endogenous conversion to nitric oxide (NO), is suggested as a compensatory fuel for disrupted NO pathways in the case of pathological stats during pregnancy. Dietary NO3 -rich supplement in the NO-deficient pregnant women is now suggested as a more appealing choice with fewer off-target effects which can attenuate hypertension and preeclampsia, improve placental blood flow and subsequently enhance maternal and neonatal health. There is also an increasing public interest and common health claims regarding beneficial effects of NO3 -rich dietary supplements like beetroot byproducts in pregnant women...
January 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29328396/placenta%C3%A2-associated-serum-exosomal-mir%C3%A2-155-derived-from-patients-with-preeclampsia-inhibits-enos-expression-in-human-umbilical-vein-endothelial-cells
#7
Li Shen, Yujing Li, Ruotian Li, Zhenyu Diao, Muyi Yany, Mengfei Wu, Haixiang Sun, Guijun Yan, Yali Hu
Preeclampsia (PE) is considered to be initiated by abnormal placentation in early pregnancy and results in systemic endothelial cell dysfunction in the second or third trimester. MicroRNAs (miRs) expressed in the human placenta can be secreted into maternal circulation via exosomes, which are secreted extracellular vesicles that serve important roles in intercellular communication. The present study hypothesized that upregulation of placenta‑associated serum exosomal miR‑155 from patients with PE may suppress endothelial nitric oxide synthase (eNOS) expression in endothelial cells...
March 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29311569/hepatic-dysfunction-and-thrombocytopenia-induced-by-excess-sflt1-in-mice-lacking-endothelial-nitric-oxide-synthase
#8
Yuji Oe, Mieko Ko, Tomofumi Fushima, Emiko Sato, S Ananth Karumanchi, Hiroshi Sato, Junichi Sugawara, Sadayoshi Ito, Nobuyuki Takahashi
Liver dysfunction is a major problem in patients with severe preeclampsia (PE), hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, or in patients receiving anti-vascular endothelial growth factor (VEGF) therapy. Excessive soluble fms-like tyrosine kinase 1 (sFlt1) that antagonizes VEGF has been implicated in the pathogenesis of PE. VEGF increases the expression of endothelial nitric oxide synthase (eNOS) and activates it. eNOS polymorphisms that cause reduced NO production are associated with PE...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29290188/the-potential-therapeutic-role-of-peroxisome-proliferatoractivated-receptors-agonist-in-preeclamptic-pregnant-rats
#9
Hayam Ibrahim Gad Allam, Abeer AbdulMoati Al Masri
OBJECTIVE: To investigate the role of peroxisome proliferator-activated receptor (PPAR)-γ agonist on renal functions and blood levels of vasoregulatory peptides by administering rosiglitazone-a PPAR-γ agonist- to nitric oxide (NO) synthase lacking pregnant rats as a creature model of preeclampsia. STUDY DESIGN: Experimental study. PLACE AND DURATION OF STUDY: Medical College at King Khaled University Hospital, Riyadh, Saudi Arabia, from July 2016 to May 2017...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29250138/apelin-as-a-novel-drug-for-treating-preeclampsia
#10
Chengshu Wang, Xiaoli Liu, Desheng Kong, Xijing Qin, Yanqing Li, Xu Teng, Xianghua Huang
Preeclampsia is a pregnancy-specific disorder of new-onset hypertension and proteinuria after 20 weeks' gestation, often resulting in poor outcome. Previous studies demonstrated that apelin is an endogenous active peptide with visodilation and anti-oxidative stress capabilities. The present study investigated the effects of apelin in a rat model of preeclampsia induced by reduced uterine perfusion pressure (RUPP). Rats with RUPP displayed hypertension and poor pregnancy outcomes, such as decreased fetal and placental weight...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29235018/inverse-correlation-between-maternal-plasma-asymmetric-dimethylarginine-adma-and-birthweight-percentile-in-women-with-impaired-placental-perfusion-circulating-adma-as-an-no-independent-indicator-of-fetal-growth-restriction
#11
Dimitrios Tsikas, Alexander Bollenbach, Makrina D Savvidou
L-Arginine (Arg) is the enzymatic precursor of nitric oxide (NO) which has multiple biological functions. Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are endogenous inhibitors of NO. We hypothesized that the ADMA and SDMA have additional biological functions in pregnancy, beyond NO synthesis, and may play a role in the regulation of birthweight (BW). To investigate this issue, we measured the plasma concentration of ADMA, SDMA, Arg and the NO metabolites nitrite and nitrate, at 23-25 weeks of gestation in women with normal placental function (Group 1) and in women with impaired placental perfusion; 19 of these women had normal outcome (Group 2), 14 had a fetus that was growth restricted (Group 3), and 10 women eventually developed preeclampsia (Group 4)...
February 2018: Amino Acids
https://www.readbyqxmd.com/read/29229321/the-role-of-aspirin-heparin-and-other-interventions-in-the-prevention-and-treatment-of-fetal-growth-restriction
#12
REVIEW
Katie M Groom, Anna L David
Fetal growth restriction and related placental pathologies such as preeclampsia, stillbirth, and placental abruption are believed to arise in early pregnancy when inadequate remodeling of the maternal spiral arteries leads to persistent high-resistance and low-flow uteroplacental circulation. The consequent placental ischaemia, reperfusion injury, and oxidative stress are associated with an imbalance in angiogenic/antiangiogenic factors. Many interventions have centered on the prevention and/or treatment of preeclampsia with results pertaining to fetal growth restriction and small-for-gestational-age pregnancy often included as secondary outcomes because of the common pathophysiology...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29153679/hypertensive-disorders-of-pregnancy-in-women-with-gestational-diabetes-mellitus-from-rio-de-janeiro-brazil
#13
Luciana Lourenço Gomes Dos Santos da Silva, Cláudia Saunders, Aline Bull Ferreira Campos, Gabriella Pinto Belfort, Patricia de Carvalho Padilha, Rosangela Alves Pereira, Rita Guérios Bornia
Pregnant women with Gestational Diabetes Mellitus (GDM) have a greater chance of developing Hypertensive Disorders of Pregnancy (HDP) by the effect of insulin resistance in nitric oxide action.This study aims to describe factors associated with the development of HDP in pregnant women with GDM, assisted in a public maternity hospital in Rio de Janeiro, Brazil. This is a cross-sectional study including 292 pregnant adult women with GDM assisted at Maternidade Escola of the Universidade Federal do Rio de Janeiro...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29055408/phosphodiesterases-and-preeclampsia
#14
Anne Brandolt Larré, Aline Parisotto, Bruna Fagundes Rockenbach, Débora Montenegro Pasin, Cláudia Capellari, Daniele Cristovão Escouto, Bartira Ercília Pinheiro da Costa, Carlos Eduardo Poli-de-Figueiredo
Antagonizing vasodilation has been considered one of the potential mechanisms underlying the pathophysiology of preeclampsia. Phosphodiesterases hydrolyze cGMP, interfering with the action of nitric oxide on vascular smooth muscle, thus causing vasoconstriction. We hypothesize that the phosphodiesterases in maternal plasma, phosphodiesterase-5 in particular, may be linked to clinical manifestations in preeclampsia syndrome.
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29055406/the-role-of-soluble-epoxide-hydrolase-in-preeclampsia
#15
Julia M Santos, Jung-A Park, Aby Joiakim, David A Putt, Robert N Taylor, Hyesook Kim
Preeclampsia is a serious complication of pregnancy characterized by the development of vasospasm, hypertension and often associated with proteinuria after the 20th week of gestation. Because termination of pregnancy results in the most efficacious resolution of preeclampsia, it is a leading cause of premature delivery worldwide. In pregnancy, 14,15-epoxyeicosatrienoic acids (EETs) have been shown to facilitate uterine blood flow during preeclampsia, in which the classic vasodilator agents such as nitric oxide and prostacyclin are reduced...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28981319/vitamin-d-supplementation-prevents-placental-ischemia-induced-endothelial-dysfunction-by-downregulating-placental-soluble-fms-like-tyrosine-kinase-1
#16
Su-Ling Ma, Xiao-Yu Tian, Ya-Qi Wang, Hui-Feng Zhang, Lei Zhang
Maternal vitamin D deficiency in pregnancy has been associated with an increased risk of preeclampsia. Vascular endothelial dysfunction is a major phenotype of pregnancies with preeclampsia, contributing to increased maternal hypertension and proteinuria. We sought to determine whether vitamin D supplementation would alleviate preeclampsia associated endothelial dysfunction and explore the underlying mechanism using the reduced uterine perfusion pressure (RUPP) rat model. RUPP operated rats were supplemented with 1,25(OH)2D (RUPP+VD) on day 1, 7, and 14 of pregnancy by subcutaneous injection...
October 5, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28962702/involvement-of-dysregulated-ikca-and-skca-channels-in-preeclampsia
#17
Fan-Fan Li, Meng-Zhou He, Yin Xie, Yuan-Yuan Wu, Mei-Tao Yang, Yao Fan, Fu-Yuan Qiao, Dong-Rui Deng
INTRODUCTION: Excessive constriction of placental chorionic plate arteries (CPAs) may be associated with preeclampsia (PE). Nitric oxide (NO) as well as intermediate and small Ca(2+)-activated K(+) channels (IKCa and SKCa) plays vital roles in vasodilation of CPAs. We hypothesized that dysregulated IKCa and SKCa channels may be involved in the pathogenesis of PE mediated by the impaired NO system on CPAs. METHODS: The location of IKCa and SKCa channels, activities of NO synthases (NOS), and expression levels of these molecules were studied on CPAs from 30 normal pregnancies and 30 PE...
October 2017: Placenta
https://www.readbyqxmd.com/read/28942512/altered-endothelial-nitric-oxide-signaling-as-a-paradigm-for-maternal-vascular-maladaptation-in-preeclampsia
#18
REVIEW
George Osol, Nga Ling Ko, Maurizio Mandalà
PURPOSE OF REVIEW: The goal of this review is to present the newest insights into what we view as a central failure of cardiovascular adaptation in preeclampsia (PE) by focusing on one clinically significant manifestation of maternal endothelial dysfunction: nitric oxide signaling. The etiology, symptoms, and current theories of the PE syndrome are described first, followed by a review of the available evidence, and underlying causes of reduced endothelial nitric oxide (NO) signaling in PE...
September 23, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28928008/effects-of-anti-lipid-peroxidation-of-punica-granatum-fruit-extract-in-endothelial-cells-induced-by-plasma-of-severe-pre-eclamptic-patients
#19
Isri Nasifah, Setyawati Soeharto, Mukhamad Nooryanto
Preeclampsia is a pregnancy disorder characterized by hypertension and proteinuria. This disorder involves oxidative stress and changes in endothelial homeostasis. This study was aimed to seek whether an ethanolic extract of Punica granatum fruit inhibits 8-iso-PGFα formation and modulates nitric oxide (NO) in endothelial cells induced by plasma from pre-eclamptic patients. Endothelial cells were cultured from human umbilical vein endothelial cells. At confluence, endothelial cells were divided into five groups, which included endothelial cells exposed to 2% plasma from normal pregnancy (NP), endothelial cells exposed to 2% plasma from pre-eclamptic patients (PP), endothelial cells exposed to PP in the presence of ethanolic extract of P...
October 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28881463/a-family-based-study-of-carbon-monoxide-and-nitric-oxide-signalling-genes-and-preeclampsia
#20
Anna E Bauer, Christy L Avery, Min Shi, Clarice R Weinberg, Andrew F Olshan, Quaker E Harmon, Jingchun Luo, Jenny Yang, Tracy A Manuck, Michael C Wu, Nicholas Williams, Ralph McGinnis, Linda Morgan, Kari Klungsøyr, Lill Trogstad, Per Magnus, Stephanie M Engel
BACKGROUND: Preeclampsia is thought to originate during placentation, with incomplete remodelling and perfusion of the spiral arteries leading to reduced placental vascular capacity. Nitric oxide (NO) and carbon monoxide (CO) are powerful vasodilators that play a role in the placental vascular system. Although family clustering of preeclampsia has been observed, the existing genetic literature is limited by a failure to consider both mother and child. METHODS: We conducted a nested case-control study within the Norwegian Mother and Child Birth Cohort of 1545 case-pairs and 995 control-pairs from 2540 validated dyads (2011 complete pairs, 529 missing mother or child genotype)...
January 2018: Paediatric and Perinatal Epidemiology
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