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preeclampsia Oxide nitric

Melanie Wittwer, Yann York Chow, Gus Dekker, Vicki Clifton, Margaret Arstall
INTRODUCTION: Preeclampsia is a multisystem disorder characterised by endothelial and microvascular dysfunction that develops in ∼10% of pregnancies. This study will characterise skin microvascular reactivity using laser Doppler flowmetry in women with preeclampsia compared to matched controls during pregnancy and early postpartum. METHODS: Women were recruited and studied on the diagnosis of preeclampsia and followed up for 6-months during postpartum period. Controls were matched for age, gestation and comorbidities...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
Jose A Santiago-Font, Lorena M Amaral, Jessica L Faulkner, Tarek Ibrahim, Venkata Ramana Vaka, Mark W Cunningham, Babbette D LaMarca
Preeclampsia is a hypertensive disorder of pregnancy with limited therapeutic options. In healthy pregnancy, relaxin plays an important vasodilatory role to maintain vascular compliance; however, there is currently no preclinical evidence to support the use of relaxin during preeclampsia. Therefore, the goal of this study was to test the hypothesis that recombinant human relaxin-2 (Serelaxin, Novartis, RLX) could reduce mean arterial pressure (MAP) and improve uterine artery resistance index (UARI) and nitric oxide bioavailability and/or decrease prepro-endothelin-1 (PPET-1), soluble fms-like tyrosine kinase-1 (sFlt-1) and tumor necrosis factor (TNF-alpha) in the Reduced Uterine Perfusion Pressure (RUPP) model of preeclampsia...
September 14, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Madhu Chauhan, Meena Balakrishnan, Alex Vidaeff, Uma Yallampalli, Fernando Lugo, Karin Fox, Michael Belfort, Chandra Yallampalli
RATIONALE: It is not known if decreases in trophoblast invasion promoting peptide, adrenomedullin2 (ADM2) system is associated with preeclampsia (PreE). OBJECTIVE: Assess the changes in ADM2 levels in Plasma, placenta and amniotic fluid (AF) and its receptor components in placenta from PreE pregnancy compared to the age-matched normal; and study the effect of ADM2 on synthesis of nitric oxide (NO), endothelial nitric oxide synthase (eNOS), matrix-metalloproteinase-2 and -9 (MMP2/9) in trophoblast cells...
September 1, 2016: Journal of Clinical Endocrinology and Metabolism
R J Madoglio, L M S S Rugolo, C S Kurokawa, M P A Sá, J C Lyra, L C O Antunes
Although oxidative stress and inflammation are important mechanisms in the pathophysiology of preeclampsia and preterm diseases, their contribution to the respiratory prognosis of premature infants of hypertensive mothers is not known. Our objective was to determine the levels of oxidative stress and inflammation markers in the airways of premature infants born to hypertensive and normotensive mothers, in the first 72 h of life, and to investigate whether they are predictors of bronchopulmonary dysplasia (BPD)/death...
August 1, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Rong-Rong Xuan, Ting-Ting Niu, Hai-Min Chen
To investigate the antioxidative effect of astaxanthin on Nω-nitro-L-arginine methyl ester (L-NAME)-induced preeclamptic rats. Cell survival, the level of reactive oxygen species (ROS) and the changes in mitochondrial membrane potential (MMP) were examined in astaxanthin and H2O2-treated human umbilical vein endothelial cells (HUVECs). The preeclamptic Sprague-Dawley (SD) rat model was established by injection of L‑NAME and treatment with astaxanthin. The activities of malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide synthase (NOS) in serum were analyzed...
September 2016: Molecular Medicine Reports
J S Possomato-Vieira, R A Khalil
Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead to maternal and fetal morbidity and mortality. Although the causative factors and pathophysiological mechanisms are unclear, endothelial dysfunction is a major hallmark of preeclampsia. Clinical tests and experimental research have suggested that generalized endotheliosis in the systemic, renal, cerebral, and hepatic circulation could decrease endothelium-derived vasodilators such as nitric oxide, prostacyclin, and hyperpolarization factor and increase vasoconstrictors such as endothelin-1 and thromboxane A2, leading to increased vasoconstriction, hypertension, and other manifestation of preeclampsia...
2016: Advances in Pharmacology
Suzanne D Burke, Zsuzsanna K Zsengellér, Eliyahu V Khankin, Agnes S Lo, Augustine Rajakumar, Jennifer J DuPont, Amy McCurley, Mary E Moss, Dongsheng Zhang, Christopher D Clark, Alice Wang, Ellen W Seely, Peter M Kang, Isaac E Stillman, Iris Z Jaffe, S Ananth Karumanchi
Preeclampsia is a hypertensive disorder of pregnancy in which patients develop profound sensitivity to vasopressors, such as angiotensin II, and is associated with substantial morbidity for the mother and fetus. Enhanced vasoconstrictor sensitivity and elevations in soluble fms-like tyrosine kinase 1 (sFLT1), a circulating antiangiogenic protein, precede clinical signs and symptoms of preeclampsia. Here, we report that overexpression of sFlt1 in pregnant mice induced angiotensin II sensitivity and hypertension by impairing endothelial nitric oxide synthase (eNOS) phosphorylation and promoting oxidative stress in the vasculature...
July 1, 2016: Journal of Clinical Investigation
You-Lin Tain, Chien-Ning Hsu, Chien-Te Lee, Yu-Ju Lin, Ching-Chou Tsai
Adulthood hypertension can be programmed by preeclampsia. Preeclampsia is associated with an imbalance in vasoactive factors, including nitric oxide (NO), hydrogen sulfide (H2S), and renin-angiotensin system (RAS). We examined whether maternal N-acetylcysteine (NAC) therapy prevented maternal suramin treatment-induced programmed hypertension in offspring and explored the effects of this therapy on NO, H2S, and RAS pathways in the kidneys. Pregnant Sprague-Dawley rats were intraperitoneally administered 60 mg/kg suramin alone on Gestational Days 10 and 11 and were treated with or without 1% NAC through drinking water during the entire pregnancy and lactation period...
July 2016: Biology of Reproduction
Victor Hugo Gonçalves-Rizzi, Jose Sergio Possomato-Vieira, Tamiris Uracs Sales Graça, Regina Aparecida Nascimento, Carlos A Dias-Junior
Preeclampsia is a pregnancy-associated disorder characterized by hypertension with uncertain pathogenesis. Increases in antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt-1) and reductions in nitric oxide (NO) bioavailability have been observed in preeclamptic women. However, the specific mechanisms linking these detrimental changes to the hypertension-in-pregnancy are not clearly understood. In this regard, while recent findings have suggested that nitrite-derived NO formation exerts antihypertensive and antioxidant effects, no previous study has examined these responses to orally administered nitrite in hypertension-in-pregnancy...
July 1, 2016: Nitric Oxide: Biology and Chemistry
Anichavezhi Devendran, Sreekala Nampoothiri, Deepak Gopal Shewade, Suvro Chatterjee, Balachandar Jayaraman, Adithan Chandrasekharan
BACKGROUND: Variants in the candidate genes eNOS, CYP11B2 and ACE have been implicated as liable biomarkers that can predict complications like hypertension and preeclampsia. Studies on the impact and distribution of these variants on healthy pregnancy have not been done so far in south Indian or in any of the native Indian population. Examining these variants could lay a strong basis in understanding the genetic aspects of preeclampsia and further offer effective means in early risk assessment in a preeclampsia...
October 2015: Journal of Reproduction & Infertility
Elizabeth Phipps, Devika Prasanna, Wunnie Brima, Belinda Jim
Preeclampsia is becoming an increasingly common diagnosis in the developed world and remains a high cause of maternal and fetal morbidity and mortality in the developing world. Delay in childbearing in the developed world feeds into the risk factors associated with preeclampsia, which include older maternal age, obesity, and/or vascular diseases. Inadequate prenatal care partially explains the persistent high prevalence in the developing world. In this review, we begin by presenting the most recent concepts in the pathogenesis of preeclampsia...
June 6, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Anne Marijn van der Graaf, Nina D Paauw, Tsjitske J Toering, Martin Feelisch, Marijke M Faas, Thomas R Sutton, Magdalena Minnion, Joop D Lefrandt, Sicco A Scherjon, Arie Franx, Gerjan Navis, A Titia Lely
Women with a history of preeclampsia have an increased risk for cardiovascular diseases later in life. Persistent vascular alterations in the postpartum period might contribute to this increased risk. The current study assessed arterial stiffness under low sodium (LS) and high sodium (HS) conditions in a well-characterized group of formerly early-onset preeclamptic (fPE) women and formerly pregnant (fHP) women. Eighteen fHP and 18 fPE women were studied at an average of 5 yr after pregnancy on 1 wk of LS (50 mmol Na(+)/day) and 1 wk of HS (200 mmol Na(+)/day) intake...
June 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
L Du, F He, L Kuang, W Tang, Y Li, D Chen
Disruption of nitric oxide pathway and endoplasmic reticulum (ER) stress had been observed in preeclampsia (PE). However, the correlation and overall detailed expression profiles of ER stress-related markers and endothelial nitric oxide synthase/inducible nitric oxide synthase (eNOS/iNOS) in patients with PE were poorly understood. In this study, placental protein expression of ER stress-related markers as well as eNOS/iNOS in normotensive control (n=32) and PE pregnancies (n=32) was examined by western blot...
March 31, 2016: Journal of Human Hypertension
Louise Ghesquière, Elodie Clouqueur, Charles Garabedian, Vassili Tsatsaris, Veronique Houfflin-Debarge
Preeclampsia (PE), a specific complication of pregnancy, is one of the most frequent causes of maternal and fetal morbidity and mortality in the world. Recently, PE risk calculation algorithms allowing early detection of PE in the first trimester of pregnancy have been described. The aim of early detection would be to rapidly introduce an effective preventive treatment. The aim of our work is to study the different preventive treatments through the literature. Aspirin has some efficiency and reduces the risk of PE from 10 to 24%...
April 2016: La Presse Médicale
Breno José Acauan Filho, Bartira Ercilia Pinheiro da Costa, Patrícia Barcelos Ogando, Matias Costa Vieira, Ivan Carlos Antonello, Carlos Eduardo Poli-de-Figueiredo
OBJECTIVES: To compare nitric oxide (NO) serum levels in women with and without preeclampsia. METHODS: 106 women were classified into preeclampsia group (n = 40) and normotensive group (n = 66). NO content was measured in the serum. Clinical and laboratorial data were recorded for comparison. RESULTS: Preeclampsia presented a significant increase in nitrate and NOx levels compared to the control group. Uric acid, gestational age, systolic and diastolic blood pressure, and creatinine showed correlation with nitrates and NOx...
May 2016: Hypertension in Pregnancy
Fangfang Zeng, Sui Zhu, Martin Chi-Sang Wong, Zuyao Yang, Jinling Tang, Keshen Li, Xuefen Su
Previous studies have examined the role of three NOS3 gene polymorphisms [G894T, T-786C, and the variable number of tandem repeats 4b/a (VNTR 4b/a)] in the susceptibility to preeclampsia with inconclusive findings. We therefore conducted an updated meta-analysis by including more studies. The most appropriate genetic model was chosen for each polymorphism by using a well-established method. Pooled results indicated that, compared with the GT+GG genotype, the TT genotype of G894T was associated with an increased risk of preeclampsia (odds ratio (OR) = 1...
2016: Scientific Reports
Nadine Haase, Michaela Golic, Florian Herse, Julianna Rugor, Dominik Linz, Maria Emilia Solano, Dominik N Müller, Ralf Dechend
Relaxin is a peptide related to pregnancy that induces nitric oxide-related and gelatinase-related effects, allowing vasodilation and pregnancy-related adjustments permitting parturition to occur. Relaxin controls the hemodynamic and renovascular adaptive changes that occur during pregnancy. Interest has evolved regarding relaxin and a therapeutic principle in preeclampsia and heart failure. Preeclampsia is a pregnancy disorder, featuring hypertension, proteinuria and placental anomalies. We investigated relaxin in an established transgenic rat model of preeclampsia, where the phenotype is induced by angiotensin (Ang)-II production in mid pregnancy...
2016: PloS One
Sarah A Marshall, Chen Huei Leo, Sevvandi N Senadheera, Jane E Girling, Marianne Tare, Laura J Parry
Pregnancy is associated with reduced peripheral vascular resistance, underpinned by changes in endothelial and smooth muscle function. Failure of the maternal vasculature to adapt correctly leads to serious pregnancy complications, such as preeclampsia. The peptide hormone relaxin regulates the maternal renal vasculature during pregnancy; however, little is known about its effects in other vascular beds. This study tested the hypothesis that functional adaptation of the mesenteric and uterine arteries during pregnancy will be compromised in relaxin-deficient (Rln(-/-)) mice...
May 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Andrea Leiva, Bárbara Fuenzalida, Eric Barros, Bastián Sobrevia, Rocío Salsoso, Tamara Sáez, Roberto Villalobos, Luis Silva, Indira Chiarello, Fernando Toledo, Jaime Gutiérrez, Carlos Sanhueza, Fabián Pardo, Luis Sobrevia
Preeclampsia (PE), gestational diabetes mellitus (GDM), and maternal supraphysiological hypercholesterolaemia (MSPH) are pregnancy-related conditions that cause metabolic disruptions leading to alterations of the mother, fetus and neonate health. These syndromes result in fetoplacental vascular dysfunction, where nitric oxide (NO) plays a crucial role. PE characterizes by abnormal increase in the placental blood pressure and a negative correlation between NO level and fetal weight, suggesting that increased NO level and oxidative stress could be involved...
2016: Current Vascular Pharmacology
Styliani Goulopoulou, Camilla F Wenceslau, Cameron G McCarthy, Takayuki Matsumoto, R Clinton Webb
Bacterial infections increase risk for pregnancy complications, such as preeclampsia and preterm birth. Unmethylated CpG DNA sequences are present in bacterial DNA and have immunostimulatory effects. Maternal exposure to CpG DNA induces fetal demise and craniofacial malformations; however, the effects of CpG DNA on maternal cardiovascular health have not been examined. We tested the hypothesis that exposure to synthetic CpG oligonucleotides (ODNs) during gestation would increase blood pressure and cause vascular dysfunction in pregnant rats...
April 15, 2016: American Journal of Physiology. Heart and Circulatory Physiology
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