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https://www.readbyqxmd.com/read/28616243/a-global-cross-cultural-study-examining-the-relationship-between-employee-health-risk-status-and-work-performance-metrics
#1
Ana Howarth, Jose Quesada, Peter R Mills
BACKGROUND: Health risk assessments (HRA) are used by many organisations as a basis for developing relevant and targeted employee health and well-being interventions. However, many HRA's have a western-centric focus and therefore it is unclear whether the results can be directly extrapolated to those from non-western countries. More information regarding the differences in the associations between country status and health risks is needed along with a more global perspective of employee health risk factors and well-being overall...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28613142/mutations-in-the-fusion-protein-heptad-repeat-domains-of-human-metapneumovirus-impact-on-the-formation-of-syncytia
#2
Julia Dubois, Marie-Hélène Cavanagh, Olivier Terrier, Marie-Ève Hamelin, Bruno Lina, Rong Shi, Manuel Rosa-Calatrava, Guy Boivin
Human metapneumovirus (HMPV) is an important cause of respiratory tract infections. The mechanism by which its fusion (F) protein is responsible for variable cytopathic effects in vitro remains unknown. We aligned the F sequences of the poorly fusogenic B2/CAN98-75 strain and the hyperfusogenic A1/C-85473 strain and identified divergent residues located in the two functional heptad repeats domains (HRA and HRB). We generated recombinant viruses by inserting the mutations N135T-G139N-T143K-K166E-E167D in HRA and/or K479R-N482S in HRB, corresponding to swapped sequences from C-85473, into CAN98-75 background and investigated their impact on in vitro phenotype and fusogenicity...
June 14, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28588733/differences-in-the-sensitivity-of-ovarian-cancer-to-photodynamic-therapy-and-the-mechanisms-for-those-differences
#3
Yoshihito Yokoyama, Tatsuhiko Shigeto, Rie Miura, Asami Kobayashi, Makito Mizunuma, Aisa Yamauchi, Masayuki Futagami, Hideki Mizunuma
Protoporphyrin IX (PpIX) levels are crucial to the antitumor action of photodynamic therapy (PDT). In the present study, the underling molecular mechanisms for the variation in PpIX levels in ovarian cancer cells were investigated. Five ovarian cancer cell lines were subcutaneously grafted onto the backs of nude mice. Once tumors had developed, 5-aminolevulinic acid methyl ester hydrochloride (methyl-ALA) was administered intraperitoneally and the tumor was irradiated twice/week. PpIX levels in the tumor were assayed using high-performance liquid chromatography...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28554627/heavy-metal-exposure-from-cooked-rice-grain-ingestion-and-its-potential-health-risks-to-humans-from-total-and-bioavailable-forms-analysis
#4
S M Praveena, N A Omar
Heavy metal in rice studies has attracted a greater concern worldwide. However, there have been limited studies on marketed rice samples although it represents a vital ingestion portion for a real estimation of human health risk. This study was aimed to determine both total and bioaccessible of trace elements and heavy metals (Cd, Cr, Cu, Co, Al, Zn, As, Pb and Fe) in 22 varieties of cooked rice using an inductively coupled plasma-optical emission spectroscopy. Both total and bioaccessible of trace elements and heavy metals were digested using closed-nitric acid digestion and Rijksinstituut voor Volksgezondheid en Milieu (RIVM) in vitro digestion model, respectively...
November 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28543395/contact-urticaria-syndrome-with-ige-antibody-against-a-cefotiam-unique-structure-evoked-by-nonapparent-exposure-to-cefotiam
#5
S Takahagi, A Tanaka, K Iwamoto, K Ishii, M Hide
A 26-year-old woman presented with recurrent attacks of widespread urticaria and systemic symptoms. The patient was a nurse, and the attacks occurred only in her workplace, without an apparent trigger. A patch test to cefotiam (CTM) induced an immediate skin reaction. ELISA detected the patient's serum IgE antibody binding to CTM conjugated with human serum albumin (CTM-HSA), and her basophils released histamine in response to CTM-HSA in a histamine release assay (HRA). Both reactions in ELISA and HRA were inhibited by pretreatment of the patient's serum or basophils with cefotiam...
May 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28535717/association-of-wage-with-employee-participation-in-health-assessments-and-biometric-screening
#6
Bruce W Sherman, Carol Addy
PURPOSE: To understand differences in health risk assessment (HRA) and biometric screening participation rates among benefits-enrolled employees in association with wage category. DESIGN: Cross-sectional analysis of employee eligibility file and health benefits (wellness and claims) data. SETTING: Data from self-insured employers participating in the RightOpt private exchange (Conduent HR Services) during 2014. PARTICIPANTS: Active employees from 4 companies continuously enrolled in health insurance for which wage data were available...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28516424/differing-developmental-trajectories-in-heart-rate-responses-to-speech-stimuli-in-infants-at-high-and-low-risk-for-autism-spectrum-disorder
#7
Katherine L Perdue, Laura A Edwards, Helen Tager-Flusberg, Charles A Nelson
We investigated heart rate (HR) in infants at 3, 6, 9, and 12 months of age, at high (HRA) and low (LRC) familial risk for ASD, to identify potential endophenotypes of ASD risk related to attentional responses. HR was extracted from functional near-infrared spectroscopy recordings while infants listened to speech stimuli. Longitudinal analysis revealed that HRA infants and males generally had lower baseline HR than LRC infants and females. HRA infants showed decreased HR responses to early trials over development, while LRC infants showed increased responses...
May 17, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28510514/door-is-open-for-hras-to-make-a-comeback
#8
Jan Greene
For four years, businesses that wanted to reimburse employees for their health insurance premiums rather than buying their coverage for them were told that that was no longer allowed under the ACA. But the health reimbursement arrangement (HRA) is back, brought back to life by provisions tucked into last year's 21st Century Cure Act.
March 2017: Managed Care
https://www.readbyqxmd.com/read/28418575/effects-of-previous-osteotomy-on-outcome-of-hip-resurfacing-arthroplasty
#9
Harlan Cabot Amstutz, Michel Jean Le Duff
The effect of previous conservative surgeries on the outcome of metal-on-metal hip resurfacing arthroplasty (HRA) has not been studied. This study compared postoperative clinical scores and survivorship results of hips with and without previous osteotomies in a population of patients who underwent HRA. A total of 1101 patients (1375 hips) with a mean age of 51.3 years at the time of surgery underwent HRA at a single center. Sixty-nine patients had undergone prior surgery on the operated hip including 14 osteotomies (1 pelvic, 6 femoral, and 7 combined pelvic and femoral osteotomies)...
April 18, 2017: Orthopedics
https://www.readbyqxmd.com/read/28416973/the-utility-of-atrial-pacing-for-identifying-the-electrical-breakthrough-sites-between-the-left-atrium-and-pulmonary-veins
#10
Shinya Sugiura, Koji Matsuoka, Hideki Noda, Naoya Kurata, Misa Uemori, Hirokazu Shioji, Akihiro Takasaki, Takafumi Koji, Takashi Tanigawa, Masaaki Ito
BACKGROUND: Circumferential pulmonary vein (PV) isolation for atrial fibrillation (AF) is occasionally difficult to achieve because electrical breakthrough sites (EBSs) between the left atrium (LA) and PVs cannot be identified during ablation especially in the carina regions. METHODS: The left PVs (Lt.PVs) of 60 AF patients and the right PVs (Rt.PVs) of 37 patients undergoing PV isolation were studied. When PV isolation was not achieved after the initial circumferential PV isolation, atrial pacing was repeatedly performed from the distal coronary sinus (CSd) and high right atrium (HRA), and the time interval from the stimulus to the earliest PV potential (stimulus-PV interval) was measured using circular mapping catheters at each PV until PV isolation was achieved...
April 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28389091/workload-even-affects-hand-hygiene-in-a-highly-trained-and-well-staffed-setting-a-prospective-365-7-24-observational-study
#11
S Scheithauer, B Batzer, M Dangel, J Passweg, A Widmer
INTRODUCTION: Compliance with hand hygiene (HH) has often not proved satisfactory; high workload is a commonly self-reported reason. Previous studies comparing workload and compliance have not measured workload precisely and have focused on certain times of day. This study aimed to investigate the association between HH compliance and workload, both electronically defined 365/7/24 (primary endpoint). In addition, the quality of commonly used compliance defining methods (hand disinfectant usage, direct observation) was investigated (secondary endpoint)...
February 20, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28384664/vocalization-rate-and-consonant-production-in-toddlers-at-high-and-low-risk-for-autism
#12
Karen Chenausky, Charles Nelson, Helen Tager-Flusberg
Background: Previous work has documented lower vocalization rate and consonant acquisition delays in toddlers with autism spectrum disorder (ASD). We investigated differences in these variables at 12, 18, and 24 months in toddlers at high and low risk for ASD. Method: Vocalization rate and number of different consonants were obtained from speech samples from a prospective study of infant siblings of children with ASD. Three groups were compared: 18 toddlers at low risk for ASD (low-risk control), 18 high-risk siblings without ASD (HRA-), and 10 high-risk siblings with ASD (HRA+)...
April 3, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28384229/alcohol-abstinence-and-risk-assessment-for-second-esophageal-cancer-in-japanese-men-after-mucosectomy-for-early-esophageal-cancer
#13
Akira Yokoyama, Chikatoshi Katada, Tetsuji Yokoyama, Tomonori Yano, Kazuhiro Kaneko, Ichiro Oda, Yuichi Shimizu, Hisashi Doyama, Tomoyuki Koike, Kohei Takizawa, Motohiro Hirao, Hiroyuki Okada, Takako Yoshii, Kazuo Konishi, Takenori Yamanouchi, Takashi Tsuda, Tai Omori, Nozomu Kobayashi, Haruhisa Suzuki, Satoshi Tanabe, Keisuke Hori, Norisuke Nakayama, Hirofumi Kawakubo, Hideki Ishikawa, Manabu Muto
BACKGROUND: Alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2) and the presence of multiple esophageal Lugol-voiding lesions (LVLs; dysplasia) are strong predictors for multiple development of esophageal squamous cell carcinoma (ESCC) in East Asians. We invented a health risk appraisal (HRA) model for predicting the risk of ESCC based on drinking, smoking, dietary habits, and alcohol flushing, i.e., past or present facial flushing after drinking a glass of beer, a surrogate marker for inactive ALDH2...
2017: PloS One
https://www.readbyqxmd.com/read/28379822/improving-patient-clinician-conversations-during-annual-wellness-visits
#14
Zsolt J Nagykaldi, Ami Dave, Connor J Kristof, Tanya N Watts, Sravanthi Utpala, Elizabeth Wickersham
BACKGROUND: Health risk assessments (HRAs) have been implemented and studied for decades in various settings, but little is known about the effect of introducing HRAs on the dynamics and content of patient-clinician conversations during Medicare Annual Wellness Visits (AWVs) and whether the effective use of HRAs requires additional training and resources. METHODS: We used Conversation Analysis techniques to analyze 40 AWVs conducted in an academic family medicine residency practice...
March 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28373259/home-or-hospital-for-people-with-dementia-and-one-or-more-other-multimorbidities-what-is-the-potential-to-reduce-avoidable-emergency-admissions-the-homeward-project-protocol
#15
S Voss, S Black, J Brandling, M Buswell, R Cheston, S Cullum, K Kirby, S Purdy, C Solway, H Taylor, J Benger
INTRODUCTION: Older people with multimorbidities frequently access 999 ambulance services. When multimorbidities include dementia, the risk of ambulance use, accident and emergency (A&E) attendance and hospital admission are all increased, even when a condition is treatable in the community. People with dementia tend to do poorly in the acute hospital setting and hospital admission can result in adverse outcomes. This study aims to provide an evidence-based understanding of how older people living with dementia and other multimorbidities are using emergency ambulance services...
April 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28363892/mid-term-changes-in-blood-metal-ion-levels-after-articular-surface-replacement-arthroplasty-of-the-hip
#16
MULTICENTER STUDY
V P Galea, I Laaksonen, S J Matuszak, J W Connelly, O Muratoglu, H Malchau
AIMS: Our first aim was to determine whether there are significant changes in the level of metal ions in the blood at mid-term follow-up, in patients with an Articular Surface Replacement (ASR) arthroplasty. Secondly, we sought to identify risk factors for any increases. PATIENTS AND METHODS: The study involved 435 patients who underwent unilateral, metal-on-metal (MoM) hip resurfacing (HRA) or total hip arthroplasty (THA). These patients all had one measurement of the level of metal ions in the blood before seven years had passed post-operatively (early evaluation) and one after seven years had passed post-operatively (mid-term evaluation)...
April 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28363881/trajectories-of-depressive-symptoms-among-web-based-health-risk-assessment-participants
#17
Richard Bedrosian, Matt Hawrilenko, Heather Cole-Lewis
BACKGROUND: Health risk assessments (HRAs), which often screen for depressive symptoms, are administered to millions of employees and health plan members each year. HRA data provide an opportunity to examine longitudinal trends in depressive symptomatology, as researchers have done previously with other populations. OBJECTIVE: The primary research questions were: (1) Can we observe longitudinal trajectories in HRA populations like those observed in other study samples? (2) Do HRA variables, which primarily reflect modifiable health risks, help us to identify predictors associated with these trajectories? (3) Can we make meaningful recommendations for population health management, applicable to HRA participants, based on predictors we identify? METHODS: This study used growth mixture modeling (GMM) to examine longitudinal trends in depressive symptomatology among 22,963 participants in a Web-based HRA used by US employers and health plans...
March 31, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28339140/acquisition-of-voice-onset-time-in-toddlers-at-high-and-low-risk-for-autism-spectrum-disorder
#18
Karen Chenausky, Helen Tager-Flusberg
Although language delay is common in autism spectrum disorder (ASD), research is equivocal on whether speech development is affected. We used acoustic methods to investigate the existence of sub-perceptual differences in the speech of toddlers who developed ASD. Development of the distinction between b and p was prospectively tracked in 22 toddlers at low risk for ASD (LRC), 22 at high risk for ASD without ASD (HRA-), and 11 at high risk for ASD who were diagnosed with ASD at 36 months (HRA+). Voice onset time (VOT), the main acoustic difference between b and p, was measured from spontaneously produced words at 18, 24, and 36 months...
March 24, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28333563/effect-of-high-altitude-exposure-on-intraocular-pressure-using-goldmann-applanation-tonometry
#19
Gabriel Willmann, Kai Schommer, Maximilian Schultheiss, M Dominik Fischer, Karl-Ulrich Bartz-Schmidt, Florian Gekeler, Andreas Schatz
Willmann, Gabriel, Kai Schommer, Maximilian Schultheiss, M. Dominik Fischer, Karl-Ulrich Bartz-Schmidt, Florian Gekeler, and Andreas Schatz. Effect of high altitude exposure on intraocular pressure using Goldmann applanation tonometry. High Alt Med Biol. 00:000-000, 2017. AIMS: The aim of the study was to quantify changes of intraocular pressure (IOP) during exposure to 4559 m using the state-of-the-art method of Goldmann applanation tonometry for IOP measurement and to detect correlations between IOP and acute mountain sickness (AMS) in a prospective manner...
March 23, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28327382/health-assessment-instruments-for-people-with-intellectual-disabilities-a-systematic-review
#20
REVIEW
E J Bakker-van Gijssel, P L B J Lucassen, T C Olde Hartman, L van Son, W J J Assendelft, H M J van Schrojenstein Lantman-de Valk
BACKGROUND: People with intellectual disabilities (ID) experience health disparities and are less likely to undergo recommended age- and gender-specific screening and health promotion. New diagnoses are frequently missed. Assessments with the aid of health assessment instruments are a way to address these problems. AIM: The aim of this review is to find the available health assessment instruments for people with ID used in primary care and evaluate their quality...
March 16, 2017: Research in Developmental Disabilities
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