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https://www.readbyqxmd.com/read/27888094/nano-analyses-of-wear-particles-from-metal-on-metal-and-non-metal-on-metal-dual-modular-neck-hip-arthroplasty
#1
Zhidao Xia, Benjamin F Ricciardi, Zhao Liu, Christopher von Ruhland, Mike Ward, Alex Lord, Louise Hughes, Steven R Goldring, Edward Purdue, David Murray, Giorgio Perino
Increased failure rates due to metallic wear particle-associated adverse local tissue reactions (ALTR) is a significant clinical problem in resurfacing and total hip arthroplasty. Retrieved periprosthetic tissue of 53 cases with corrosion/conventional metallic wear particles from 285 revision operations for ALTR was selected for nano-analyses. Three major classes of hip implants associated with ALTR, metal-on-metal hip resurfacing arthroplasty (MoM HRA) and large head total hip replacement (MoM LHTHA) and non-metal-on-metal dual modular neck total hip replacement (Non-MoM DMNTHA) were included...
November 22, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27883260/the-use-of-incretin-agents-and-risk-of-acute-and-chronic-pancreatitis-a-population-based-cohort-study
#2
Lotte M Knapen, Roy G P J de Jong, Johanna H M Driessen, Yolande C Keulemans, Nielka P van Erp, Marie L De Bruin, Hubert G M Leufkens, Sander Croes, Frank de Vries
BACKGROUND: Incretin-based therapies (Dipeptidyl Peptidase 4 inhibitors and Glucagon-Like Peptide-1 Receptor Agonists) are effective new agents for the treatment of Type 2 Diabetes Mellitus (T2DM). While incretin-based therapies have been associated with pancreatitis, evidence is conflicting for acute pancreatitis and lacks for chronic pancreatitis. OBJECTIVE: To determine the association between the use of incretin agents and the risk of any, acute and chronic pancreatitis...
November 24, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27872117/protocol-for-a-multicentre-randomised-feasibility-trial-evaluating-early-surgery-alone-in-low-rectal-cancer-sailor
#3
Dean A Harris, Kymberley Thorne, Hayley Hutchings, Saiful Islam, Gail Holland, Olivia Hatcher, Sarah Gwynne, Ian Jenkins, Peter Coyne, Michael Duff, Melanie Feldman, Des C Winter, Simon Gollins, Phil Quirke, Nick West, Gina Brown, Deborah Fitzsimmons, Alan Brown, John Beynon
INTRODUCTION: There are 11 500 rectal cancers diagnosed annually in the UK. Although surgery remains the primary treatment, there is evidence that preoperative radiotherapy (RT) improves local recurrence rates. High-quality surgery in rectal cancer is equally important in minimising local recurrence. Advances in MRI-guided prediction of resection margin status and improvements in abdominoperineal excision of the rectum (APER) technique supports a reassessment of the contribution of preoperative RT...
November 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27852400/-diagnostic-performance-of-laser-retinal-imaging-in-the-epiretinal-membrane
#4
Y J Huo, L L Yang, W B Wei
Objective: To determine the diagnostic performance of confocal scanning laser ophthalmoscope (cSLO)-based retinal imaging in the epiretinal membrane (ERM) patients. Methods: Prospective case series study. Twenty-six patients (32 eyes) with ERM determined by spectral domain optical coherence tomography (SD-OCT) were recruited from June 2015 to October 2015 in the Beijing Tongren Eye Center. All subjects underwent retinal imaging using the cSLO-based Heidelberg MultiColor (Spectralis HRA-2; Heidelberg Engineering) technology and the traditional color fundus camera...
November 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27845887/a-review-of-heavy-metals-in-indoor-dust-and-its-human-health-risk-implications
#5
Sock Yin Tan, Sarva Mangala Praveena, Emilia Zainal Abidin, Manraj Singh Cheema
Indoor dust acts as a media for heavy metal deposition. Past studies have shown that heavy metal concentration in indoor dust is affected by local human activities and atmospheric transport can have harmful effects on human health. Additionally, children are more sensitive to heavy metals due to their hand-to-mouth behaviour and rapid body development. However, limited information on health risks were found in past dust studies as these studies aimed to identify heavy metal concentrations and sources of indoor dust...
December 1, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27830330/risk-factors-of-nonadherence-to-colonoscopy-surveillance-after-polypectomy-and-its-impact-on-clinical-outcomes-a-kasid-multicenter-study
#6
Chung Hyun Tae, Chang Mo Moon, Seong-Eun Kim, Sung-Ae Jung, Chang Soo Eun, Jae Jun Park, Geom Seog Seo, Jae Myung Cha, Sung Chul Park, Jaeyoung Chun, Hyun Jung Lee, Yunho Jung, Jin Oh Kim, Young-Eun Joo, Dong Il Park
BACKGROUND: An optimal surveillance program is important to prevent advanced colorectal neoplasm. In this context, we have evaluated the cumulative risk of high-risk adenoma (HRA) or colorectal cancer (CRC) according to surveillance interval time after polypectomy. In addition, we assessed risk factors for late surveillance to determine whether late surveillance can impact the risk of subsequent advanced colorectal neoplasm. METHODS: This was a multicenter retrospective cohort study involving 3562 subjects who had undergone removal of at least one adenoma at the index colonoscopy and who subsequently underwent a surveillance colonoscopy...
November 9, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27829336/effectiveness-of-a-standardized-and-specific-follow-up-in-memory-centers-in-patients-with-alzheimer-s-disease
#7
Laure Rouch, Philippe Cestac, Charlène Cool, Catherine Helmer, Jean-François Dartigues, Claudine Berr, Olivier Rouaud, Bruno Vellas, Sandrine Andrieu
OBJECTIVES: To compare the 4-year survival, institutionalization, cognitive and functional decline of Alzheimer's patients with specific follow-up in memory centers versus usual care. DESIGN: Four year longitudinal follow-up. SETTINGS: The French Network of memory centers in Alzheimer's disease (REAL-FR study) and The French population-based study (3C study). PARTICIPANTS: 728 patients aged ≥ 65, living at home, meeting criteria for probable Alzheimer's disease and having Mini Mental State Examination (MMSE) scores between 10 and 26 at baseline were included...
November 8, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27806411/anal-chromoendoscopy-using-gastroenterological-video-endoscopes-a-new-method-to-perform-high-resolution-anoscopy-for-diagnosing-intraepithelial-neoplasia-and-anal-carcinoma-in-hiv-infected-patients
#8
M Oette, U Wieland, M Schünemann, J Haes, S Reuter, B Jensen, A Sagir, H Pfister, D Häussinger
Introduction: Anal carcinoma represents an increasing problem in HIV-infected patients. Anal intraepithelial neoplasia (AIN), the precursor lesion, is currently diagnosed by high-resolution anoscopy (HRA) using optical magnification derived from gynecological colposcopy. This prospective study evaluates anal chromoendoscopy (ACE) using standard gastroenterological video-endoscopes in diagnosing AIN. Methods: After clinical examination, proctoscopy and surface staining with acetic acid followed by Lugol's solution, ACE was performed with a mucosectomy cap on the tip of the endoscope...
November 2, 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27780174/clinical-spectrum-of-macular-foveal-capillaries-evaluated-with-optical-coherence-tomography-angiography
#9
Maria V Cicinelli, Adriano Carnevali, Alessandro Rabiolo, Lea Querques, Ilaria Zucchiatti, Vincenzo Scorcia, Francesco Bandello, Giuseppe Querques
PURPOSE: To describe macular-foveal capillaries (MFC) by means of optical coherence tomography angiography and to identify the clinical spectrum of this angiographic feature. METHODS: Patients with MFC presenting at the Medical Retina & Imaging Unit of the Department of Ophthalmology, University Vita-Salute San Raffaele in Milan were recruited. Patients underwent a complete ophthalmologic examination that included slit-lamp examination, fundus examination, measurement of best-corrected visual acuity, fundus autofluorescence, and spectral-domain optical coherence tomography (Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany)...
July 12, 2016: Retina
https://www.readbyqxmd.com/read/27765999/hydrophobic-resorufamine-derivatives-potent-and-selective-red-fluorescent-probes-of-the-endoplasmic-reticulum-of-mammalian-cells
#10
Sahishna Phaniraj, Zhe Gao, Digamber Rane, Blake R Peterson
The endoplasmic reticulum (ER) of eukaryotic cells plays critical roles in the processing of secreted and transmembrane proteins. Defects in these functions are associated with a wide range of pathologies. To image this organelle, cells are often treated with fluorescent ER-Tracker dyes. Although these compounds are selective, existing red fluorescent probes of the ER are costly glibenclamide derivatives that inhibit ER-associated sulphonylurea receptors. To provide simpler and more cost-effective red fluorescent probes of the ER, we synthesized amino analogues of the fluorophore resorufin...
December 2016: Dyes and Pigments: An International Journal
https://www.readbyqxmd.com/read/27759474/poor-10-year-survivorship-of-hip-resurfacing-arthroplasty
#11
Matti Seppänen, Mikko Karvonen, Petri Virolainen, Ville Remes, Pekka Pulkkinen, Antti Eskelinen, Antti Liukas, Keijo T Mäkelä
Background and purpose - In a previous registry report, short-term implant survival of hip resurfacing arthroplasty (HRA) in Finland was found to be comparable to that of total hip arthroplasty (THA). Since then, it has become evident that adverse reactions to metal debris (ARMDs) may also be associated with HRA, not only with large-diameter head metal-on-metal THA. The aim of the study was to assess medium- to long-term survivorship of HRA based on the Finnish Arthroplasty Register (FAR). Patients and methods - 5,068 HRAs performed during the period 2001-2013 in Finland were included...
December 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27750352/dynamics-of-adrenocorticotropin-after-application-of-metyrapone
#12
S Noe, A von Werder, R Iakoubov, H Schneider, M Thaler, P Luppa, B Neu
Purpose: To investigate the kinetics of adrenocorticotropin (ACTH) following oral metyrapone administration and describe differences between ACTH-deficient and non-ACTH-deficient subjects. Methods: Patients from a tertiary endocrine center at a University Hospital in Munich, Germany, were tested for secondary adrenal insufficiency in a regular patient care setting. Metyrapone (Metopirone, HRA Pharma, France) was administered with a dosage of 40 mg/kg bodyweight at 8 a.m. Consecutive levels of ACTH were determined at 0, 60, 120, 180, and 240 min...
October 17, 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27745039/human-rights-can-inform-end-of-life-care
#13
Stephanie Jones-Berry
A palliative care charity has developed a new approach to end of life care based on the Human Rights Act (HRA).
September 14, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27667675/comparative-analysis-of-three-histologic-grading-methods-for-squamous-cell-carcinoma-of-the-lip
#14
Luciana Strieder, Cláudia Malheiros Coutinho-Camillo, Victor Costa, Danyel Elias da Cruz Perez, Luiz Paulo Kowalski, Estela Kaminagakura
OBJECTIVES: The aim of this study was to evaluate three histologic grading methods for squamous cell carcinoma (SCC) of the lip, the conventional 3-grade model proposed by the World Health Organization (WHO), tumor budding and depth of invasion (BD) model, and histologic risk assessment (HRA) model, and to correlate them with prognosis. MATERIALS AND METHODS: Fifty-three patients with lip SCC were evaluated. RESULTS: The mean age was 65 years, 69...
September 26, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27639785/a-cluster-randomized-trial-of-a-personalized-multi-condition-risk-assessment-in-primary-care
#15
Jennifer S Haas, Heather J Baer, Katyuska Eibensteiner, Elissa V Klinger, Stella St Hubert, George Getty, Phyllis Brawarsky, E John Orav, Tracy Onega, Anna N A Tosteson, David W Bates, Graham Colditz
INTRODUCTION: Personal risk for multiple conditions should be assessed in primary care. This study evaluated whether collection of risk factors to generate electronic health record (EHR)-linked health risk appraisal (HRA) for coronary heart disease, diabetes, breast cancer, and colorectal cancer was associated with improved patient-provider communication, risk assessment, and plans for breast cancer screening. METHODS: This pragmatic trial recruited adults with upcoming visits to 11 primary care practices during 2013-2014 (N=3,703)...
September 14, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27630299/axin1-expression-and-localization-in-meningiomas-and-association-to-changes-of-apc-and-e-cadherin
#16
Nives Pećina-Šlaus, Anja Kafka, Tomislav Vladušić, Hrvoje Ivan Pećina, Reno Hrašćan
BACKGROUND/AIM: Tumor suppressor gene AXIN1 is an inhibitor of Wnt signaling pathway. It down-regulates the pathway's main signaling effector molecule, beta-catenin, in an AXIN-based destruction complex. In the present study we investigated the involvement of AXIN1 in intracranial meningioma. MATERIALS AND METHODS: Loss of heterozygosity and microsatellite instability analyses were performed. The consequences of genetic changes on protein expression levels were studied in the same patients by immunohistochemistry...
September 2016: Anticancer Research
https://www.readbyqxmd.com/read/27628426/vascular-abnormalities-in-patients-with-stargardt-disease-assessed-with-optical-coherence-tomography-angiography
#17
Maurizio Battaglia Parodi, Maria Vittoria Cicinelli, Alessandro Rabiolo, Luisa Pierro, Gianluigi Bolognesi, Francesco Bandello
AIMS: To describe the vascular abnormalities in patients affected by Stargardt disease (STGD1) by means of optical coherence tomography angiography (OCT-A). METHODS: Cross-sectional case series, with the following inclusion criteria: diagnosis of STGD1, clear ocular media, and stable fixation. Patients underwent best-corrected visual acuity (BCVA), biomicroscopy, applanation tonometry, short-wavelength fundus autofluorescence (SW-FAF) (HRA Heidelberg, Germany), 3×3 Swept Source OCT-A (Topcon Corporation, Japan)...
September 14, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27622495/time-course-of-changes-in-choroidal-thickness-after-complete-mydriasis-induced-by-compound-tropicamide-in-children
#18
Zhouyue Li, Junwen Zeng, Wei Jin, Wen Long, Weizhong Lan, Xiao Yang
PURPOSE: The aim of this study was to investigate the time-course of changes in choroidal thickness (ChT) following complete mydriasis induced by compound tropicamide. METHODS: ChT was measured by OCT with the enhanced-depth imaging technique (Spectralis HRA+OCT, Heidelberg Engineering, Germany) at nine locations of the fundus: subfoveal ChT (SFChT) and ChT at 1 mm and 3 mm from the fovea in four quadrants. Mydriasis was induced with compound tropicamide (0.5% tropicamide plus 0...
2016: PloS One
https://www.readbyqxmd.com/read/27616938/greater-pupil-size-in-response-to-emotional-faces-as-an-early-marker-of-social-communicative-difficulties-in-infants-at-high-risk-for-autism
#19
Jennifer B Wagner, Rhiannon J Luyster, Helen Tager-Flusberg, Charles A Nelson
When scanning faces, individuals with autism spectrum disorder (ASD) have shown reduced visual attention (e.g., less time on eyes) and atypical autonomic responses (e.g., heightened arousal). To understand how these differences might explain sub-clinical variability in social functioning, 9-month-olds, with or without a family history of ASD, viewed emotionally-expressive faces, and gaze and pupil diameter (a measure of autonomic activation) were recorded using eye-tracking. Infants at high-risk for ASD with no subsequent clinical diagnosis (HRA-) and low-risk controls (LRC) showed similar face scanning and attention to eyes and mouth...
September 2016: Infancy: the Official Journal of the International Society on Infant Studies
https://www.readbyqxmd.com/read/27579176/evaluation-of-retinal-and-choroidal-thickness-in-fuchs-uveitis-syndrome
#20
Ozlem Balci, Mustafa Ozsutcu
Purpose. We aimed to investigate retinal and choroidal thickness in the eyes of patients with Fuchs' uveitis syndrome (FUS). Methods. Fifteen patients with unilateral FUS and 20 healthy control subjects were enrolled. Spectral domain optical coherence tomography (Spectralis HRA+OCT, 870 nm; Heidelberg Engineering, Heidelberg, Germany) was used to obtain retinal and choroidal thickness measurements. The retinal nerve fiber layer (RNFL) thickness, macular thickness, and choroidal thickness of the eyes with FUS were compared with the unaffected eye and the eyes of healthy control subjects...
2016: Journal of Ophthalmology
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