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https://www.readbyqxmd.com/read/29456277/differential-attention-to-faces-in-infant-siblings-of-children-with-autism-spectrum-disorder-and-associations-with-later-social-and-language-ability
#1
Jennifer B Wagner, Rhiannon J Luyster, Hana Moustapha, Helen Tager-Flusberg, Charles A Nelson
A growing body of literature has begun to explore social attention in infant siblings of children with autism spectrum disorder (ASD) with hopes of identifying early differences that are associated with later ASD or other aspects of development. The present study used eye-tracking to familiar (mother) and unfamiliar (stranger) faces in two groups of 6-month-old infants: infants with no family history of ASD (low-risk controls; LRC), and infants at high risk for ASD (HRA), by virtue of having an older sibling with ASD...
2018: International Journal of Behavioral Development
https://www.readbyqxmd.com/read/29455347/a-prospective-comparative-study-of-hip-resurfacing-arthroplasty-and-large-diameter-head-metal-on-metal-total-hip-arthroplasty-in-younger-patients-a-minimum-of-five-year-follow-up
#2
Ran Tao, Fan Liu, Ya-Ke Liu, Yue Lu, Hua Xu, Yi Cao, Zhen-Yu Zhou, Wei Wang
INTRODUCTION: Both hip resurfacing arthroplasty (HRA) and large-diameter head metal-on-metal total hip arthroplasty (LDH MoM THA) are generally used for young and active patients. A number of comparative studies of HRA and total hip arthroplasty have been published in the literature. However, studies that have compared HRA with LDH MoM THA are rare. The purpose of this study is to compare the mid-term results of HRA with those of LDH MoM THA in young patients. PATIENTS AND METHODS: Between 2007 and 2011, 68 patients were enrolled in the study and randomized into two groups: HRA group (28 hips) and LDH MoM THA group (40 hips)...
February 18, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29437181/quality-of-motivational-interviewing-matters-the-effect-on-participation-in-health-promotion-activities-in-a-cluster-randomized-controlled-trial
#3
Tessa A Kouwenhoven-Pasmooij, Suzan Jw Robroek, Daan Nieboer, Pieter H Helmhout, Machteld F Wery, Myriam Hunink, Alex Burdorf
Objectives This study aims to evaluate the effectiveness of a "blended" workplace health-promotion intervention, alongside identification of key components beneficial for future implementation strategies. Methods Within a cluster randomized controlled trial, 491 employees at increased risk of cardiovascular disease were allocated to the limited (N=217; 9 clusters) or extensive (N=274; 8 clusters) intervention. The extensive intervention consisted of motivational interviewing (MI) within the framework of a web-based health risk assessment (HRA), a blended care approach...
February 13, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29431149/antiretroviral-therapy-suppresses-rectal-hiv-rna-shedding-despite-inflammation-in-msm-with-rectal-c-trachomatis-and-n-gonorrhoeae-infections-a-cross-sectional-single-center-study
#4
Julian Storim, Jens Verheyen, Eva Wolff, Jeremias Wohlschlaeger, Evelyn Heintschel von Heinegg, Dirk Schadendorf, Stefan Esser
OBJECTIVES: Rectal infections with Chlamydia trachomatis and/or Neisseria gonorrhoeae (CT/NG) are common in men who have sex with men (MSM) and are linked to HIV transmission. However, rectal CT/NG infections are often asymptomatic and it is not known how they contribute to HIV transmission. We assessed clinical and cytological signs of inflammation as well as rectal HIV-RNA in HIV-infected MSM with and without CT/NG infection. METHODS: 112 HIV-positive MSM with or without rectal symptoms and with or without antiretroviral therapy who underwent high-resolution anoscopy (HRA) at the proctological outpatient centre of the University Hospital Essen, Germany, between November 2013 and February 2014 were included in this cross-sectional study...
February 3, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29421813/repeatability-and-reproducibility-of-foveal-avascular-zone-area-measurement-on-normal-eyes-by-different-optical-coherence-tomography-angiography-instruments
#5
Elisabetta Pilotto, Luisa Frizziero, Anna Crepaldi, Enrico Della Dora, Davide Deganello, Evelyn Longhin, Enrica Convento, Raffaele Parrozzani, Edoardo Midena
PURPOSE: To compare the foveal avascular zone (FAZ) area measurements produced by different optical coherence tomography angiography (OCTA). METHODS: Healthy enrolled volunteers underwent OCTA using 2 different devices: Spectralis HRA+OCTA (Heidelberg Engineering, Heidelberg, Germany) and RS-3000 Advance (Nidek, Gamagori, Japan). Two graders measured FAZ in both superficial (SCP) and deep (DCP) retinal capillary plexuses. The SCP and DCP en face images were visualized automatically segmenting 2 separate slabs defined by the arbitrary segmentation lines created by the software of each OCT device...
February 8, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29366558/monitoring-emerging-contaminants-in-the-drinking-water-of-milan-and-assessment-of-the-human-risk
#6
Francesco Riva, Sara Castiglioni, Elena Fattore, Angela Manenti, Enrico Davoli, Ettore Zuccato
Emerging Contaminants (ECs) are ubiquitous in waters, arousing concern because of their potential risks for human health and the environment. This study investigated the presence of multiple classes of ECs in 21 wells over the drinking water network of Milan, in the most inhabited and industrialized area of Italy, and assessed the risks for consumers. Samples were analyzed using liquid chromatography coupled to mass spectrometry. Human risk assessment (HRA) was conducted by comparing the measured concentrations with drinking water thresholds from guidelines or calculated in this study; first considering the exposure to each single EC and then the entire mixture...
January 16, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29357882/quantitative-investigation-of-the-direct-interaction-between-hemagglutinin-and-fusion-proteins-of-peste-des-petits-ruminant-virus-using-surface-plasmon-resonance
#7
Xuelian Meng, Ruixue Deng, Xueliang Zhu, Zhidong Zhang
BACKGROUND: The specific and dynamic interaction between the hemagglutinin (H) and fusion (F) proteins of morbilliviruses is a prerequisite for the conformational rearrangements and membrane fusion during infection process. The two heptad repeat regions (HRA and HRB) of F protein are both important for the triggering of F protein. METHODS: In this study, the direct interactions of Peste des petits ruminants virus (PPRV) H with F, HRA and HRB were quantitatively evaluated using biosensor surface plasmon resonance (SPR)...
January 22, 2018: Virology Journal
https://www.readbyqxmd.com/read/29338884/cervical-proprioception-in-a-young-population-who-spend-long-periods-on-mobile-devices-a-2-group-comparative-observational-study
#8
Andrew Portelli, Susan A Reid
OBJECTIVES: The purpose of this study was to evaluate if young people with insidious-onset neck pain who spend long periods on mobile electronic devices (known as "text neck") have impaired cervical proprioception and if this is related to time on devices. METHODS: A 2-group comparative observational study was conducted at an Australian university. Twenty-two participants with text neck and 22 asymptomatic controls, all of whom were 18 to 35 years old and spent ≥4 hours per day on unsupported electronic devices, were assessed using the head repositioning accuracy (HRA) test...
January 12, 2018: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29335408/escape-from-thymic-deletion-and-anti-leukemic-effects-of-t-cells-specific-for-hematopoietic-cell-restricted-antigen
#9
Ji-Min Ju, Min Ho Jung, Giri Nam, Woojin Kim, Sehwa Oh, Hyun Duk Kim, Joo Young Kim, Jun Chang, Sung Hak Lee, Gyeong Sin Park, Chang-Ki Min, Dong-Sup Lee, Moon Gyo Kim, Kyungho Choi, Eun Young Choi
Whether hematopoietic cell-restricted distribution of antigens affects the degree of thymic negative selection has not been investigated in detail. Here, we show that T cells specific for hematopoietic cell-restricted antigens (HRA) are not completely deleted in the thymus, using the mouse minor histocompatibility antigen H60, the expression of which is restricted to hematopoietic cells. As a result, low avidity T cells escape from thymic deletion. This incomplete thymic deletion occurs to the T cells developing de novo in the thymus of H60-positive recipients in H60-mismatched bone marrow transplantation (BMT)...
January 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29332749/long-term-effect-of-direction-movement-control-training-on-female-patients-with-chronic-neck-pain
#10
Zohreh Khosrokiani, Amir Letafatkar, Yahya Sokhanguei
BACKGROUND: Treatment of movement faults in the neck is known as an important factor in treatment of chronic neck pain. Along with the identification of site and direction of the faults, direction-movement control intervention retrains the control of the movement faults. PURPOSE: This study was designed to investigate long-term effects of a direction-movement control training on pain, disability, head repositioning accuracy, function, cervical flexor endurance, and range of motion in female patients with chronic nonspecific neck pain...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29327742/targeting-cleanups-towards-a-more-sustainable-future
#11
David O'Connor, Deyi Hou
A tension arises between society's disposition to protect people at risk from environmental pollution, and an aversion towards the potential harmful side-effects associated with cleanup activities. Here we explore how setting different cleanup standards may influence some of the environmental, social, and economic side-effects of remediation, and how they can be quantified for incorporation into cleanup target setting; these include (1) secondary environmental impacts, assessed by life cycle assessment (LCA); (2) fatalities and injuries, assessed by actuarial risk analysis; and (3) the cost effectiveness of stringent cleanup standards, assessed by the incremental cost-effectiveness ratio (ICER)...
January 12, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29316642/risk-assessment-of-potentially-toxic-elements-ptes-pollution-at-a-rural-industrial-wasteland-in-an-abandoned-metallurgy-factory-in-north-china
#12
Zheng Sun, Jiajun Chen
The potential toxic elements (PTEs) pollution problems in many rural industrial wastelands have been observed to be conspicuous. Therefore, 40 top soil samples were collected from the wasteland of a typical rural metallurgy factory in Baoding, China. The total concentrations of six key PTEs were measured. The soil properties and speciation of the PTEs were also identified. Extremely high concentrations of As, Cd, Pb, and Zn were observed in the surface soils. Using the PTEs concentration in the top soils of the rural industrial wasteland, the following indices of pollution were calculated: the pollution load index (PLI), the geo-accumulation Index (Igeo), the risk assessment code (RAC), and the health risk assessment (HRA)...
January 6, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29295752/adherence-to-follow-up-in-high-risk-adenoma-patients-diagnosed-by-and-excluded-from-the-barcelona-colorectal-cancer-screening-programme
#13
Isabel Otero, Andrea Burón, Francesc Macià, Cristina Álvarez-Urturi, Mercè Comas, Marta Román, Xavier Castells
INTRODUCTION: Colorectal cancer screening programmes have been shown to reduce incidence and mortality. High-risk adenomas (HRA) are the most frequently diagnosed lesions in these programmes, and these patients are referred to a specialist. However, few studies have evaluated the adherence of HRA patients to the recommended endoscopic follow-up. OBJECTIVES: To analyse follow-up adherence and duration in patients diagnosed with HRA in a screening programme. METHODS: Retrospective cohort study of patients diagnosed with HRA within one of the participating hospitals of the colorectal cancer screening programme of Barcelona, during the first round of the programme (2010-2011)...
December 30, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29288639/retinal-vascular-impairment-in-best-vitelliform-macular-dystrophy-assessed-by-means-of-optical-coherence-tomography-angiography
#14
Maurizio Battaglia Parodi, Francesco Romano, Maria Vittoria Cicinelli, Alessandro Rabiolo, Alessandro Arrigo, Luisa Pierro, Pierluigi Iacono, Francesco Bandello
PURPOSE: To evaluate vascular abnormalities at superficial (SCP), deep (DCP) capillary plexuses and choriocapillaris (CC) in patients with Best vitelliform macular dystrophy (BVMD) by means of optical coherence tomography angiography (OCT-A). DESIGN: Cross-sectional case series. METHODS: Sixty-six eyes of 33 patients with BVMD (sixteen males) and 33 controls were consecutively enrolled. Patients were subdivided in classic stages and underwent best-corrected visual acuity (BCVA), fundus autofluorescence and spectral domain-optical coherence tomography (Spectralis HRA+OCT; Heidelberg Engineering), and 4...
December 27, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29279134/mortality-after-an-episode-of-acute-heart-failure-in-a-cohort-of-patients-with-intermediate-ventricular-function-global-analysis-and-relationship-with-admission-department
#15
Òscar Miró, Patricia Javaloyes, Víctor Gil, Javier Jacob, Pablo Herrero-Puente, Francisco Javier Martín-Sánchez, Eva Salvo, Héctor Alonso, María Ángeles Juan Gómez, John Parissis, Pere Llorens
BACKGROUND AND OBJECTIVE: To compare the outcome of patients with acute heart failure (AHF) with a mid-range left ventricular ejection fraction (HFmrEF) with patients with a reduced (HFrEF) or preserved (HFpEF) left ventricular ejection fraction. PATIENTS AND METHOD: A prospective observational study included patients diagnosed with AHF in 41 emergency departments. Patients were divided into 3 groups: HFrEF<40%, HFmrEF 40-49% and HFpEF≥50%. We collected 38 independent variables and the adjusted and crude all-cause mortality at one-year in the HFmrEF group was compared with that of the HFrEF and HFpEF groups...
December 23, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29277514/hip-resurfacing-before-50-years-of-age-a-prospective-study-of-979-hips-with-a-mean-follow-up-of-5-1-years
#16
J Girard, A Lons, N Ramdane, S Putman
BACKGROUND: Hip resurfacing arthroplasty (HRA) is an alternative to total hip arthroplasty (THA) for the treatment of hip osteoarthritis in patients younger than 50 years. Data on revision rates after HRA are conflicting. The National Institute for Health and Care Excellence (NICE) recommends performing only those hip arthroplasty procedures associated with 10-year revision rates no greater than 5% (0.5% per year). Follow-up studies can rapidly determine whether this criterion is met...
December 22, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29238613/public-involvement-could-usefully-inform-ethical-review-but-rarely-does-what-are-the-implications
#17
Kristina Staley, Jim Elliott
Plain English summary: Researchers carrying out research in the NHS in England have to obtain approval for their study from an NHS Research Ethics Committee (REC). Involving the public in research helps to ensure studies are ethically acceptable to the people taking part, and therefore supports the REC review. The form used by RECs asks researchers to describe any involvement that has taken place before the review or any planned for the future. We analysed researchers' reports of involvement in 2748 applications to RECs in 2014, to assess how well their approaches to involvement are informing the review process...
2017: Research Involvement and Engagement
https://www.readbyqxmd.com/read/29212939/the-heptad-repeat-c-domain-of-the-respiratory-syncytial-virus-fusion-protein-plays-a-key-role-in-membrane-fusion
#18
Imogen M Bermingham, Keith J Chappell, Daniel Watterson, Paul R Young
Respiratory syncytial virus (RSV) mediates host cell entry through the fusion (F) protein, which undergoes a conformational change to facilitate the merger of viral and host lipid membrane envelopes. RSV F comprises a trimer of disulfide bonded F1 and F2 subunits that is present on the virion surface in a 'metastable' pre-fusion state. This pre-fusion form is readily triggered to undergo refolding to bring two heptad repeats (HRA and HRB) into close proximity to form a six-helix bundle that stabilizes the post-fusion form and provides the free energy required for membrane fusion...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29204065/anal-cancer-and-anal-cancer-precursors-in-women-with-a-history-of-hpv-related-dysplasia-and-cancer
#19
Elizabeth A Stier, Elizabeth Y Chiao
The epidemiology of anal cancer in the U.S. has changed over the past 3 decades. During this period the incidence of anal cancer has increased among both men and women. Of note, women with a history of anogenital HPV infection are at higher risk than the general population for anal cancer. The increased risk ranged from increased incidence rate ratios ranging from 1.82 to 6.3 in women with a history of cervical cancer, to 4.2-16.4 in women with a history of prior cervical intraepithelial neoplasia 3 (CIN 3)...
June 2017: Seminars in Colon & Rectal Surgery
https://www.readbyqxmd.com/read/29190817/screening-for-precancerous-anal-lesions-with-p16-ki67-immunostaining-in-hiv-infected-msm
#20
Sergio Serrano-Villar, Beatriz Hernández-Novoa, Amparo de Benito, Jorge Del Romero, Antonio Ocampo, José Ramón Blanco, Mar Masiá, Elena Sendagorta, Gonzalo Sanz, Santiago Moreno, José A Pérez-Molina
BACKGROUND: Screening of anal cancer in HIV-infected MSM with anal cytology results in high rates of false positive results and elevated burden of high-resolution anoscopies. High-risk HPV up-regulates p16 and Ki67 expression in epithelial cells. We assessed the usefulness of P16/Ki-67 immunostaining cytology for the diagnosis of precancerous anal lesions. METHODOLOGY: Cross-sectional multicenter study. Concomitant anal liquid cytology with p16/Ki-67 immunostaining and HRA with biopsy of acetowhite lugol-negative lesions was performed in HIV-infected MSM...
2017: PloS One
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