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https://www.readbyqxmd.com/read/29934358/factors-associated-with-anal-cancer-screening-follow-up-by-high-resolution-anoscopy
#1
Kaan Z Apaydin, Andrew Nguyen, Christina P C Borba, Derri L Shtasel, Sharon Ulery, Kenneth H Mayer, Alex S Keuroghlian
OBJECTIVES: High-resolution anoscopy (HRA) is a potential screening method for detection of anal cancer precursors. We evaluated factors associated with adherence to recommended HRA follow-up time intervals among men who have sex with men (MSM). METHODS: We employed a retrospective, observational cohort study with 155 MSM screened by HRA between 1 April 2011 and 31 March 2016 at a Federally Qualified Health Centre in Boston, Massachusetts. RESULTS: The sample was 80% white, with a median age of 48 (non-normal distribution, IQR 15)...
June 22, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29912603/midterm-risk-of-cancer-with-metal-on-metal-hip-replacements-not-increased-in-a-finnish-population
#2
Elina Ekman, Inari Laaksonen, Antti Eskelinen, Pekka Pulkkinen, Eero Pukkala, Keijo Mäkelä
Background and purpose - Metal-on-metal (MoM) total hip arthroplasty (THA) and hip resurfacing arthroplasty (HRA) have been widely used during the early 21st century. We assessed the midterm risk of cancer of patients treated with modern MoM hip implants compared with patients with non-MoM hip implants and the general Finnish population with special interest in soft tissue sarcomas and basalioma due to the findings of our previous report. Patients and methods - All large-diameter head MoM THAs and hip resurfacings performed in Finland between 2001 and 2010 were extracted from the Finnish Arthroplasty Register (10,728 patients)...
June 18, 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/29896815/hemodialysis-related-amyloidosis-is-it-still-relevant
#3
Shuzo Kaneko, Kunihiro Yamagata
Accumulation of amyloid fibrils from β2-microglobulin (β2M) was first recognized as a characteristic osteoarticular complication in long-term hemodialysis (HD) patients and called "HD-related amyloidosis" (HRA). However, this syndrome can also be observed in end-stage renal diseases (ESRD) patients undergoing peritoneal dialysis, and even in patients with chronic renal failure before the initiation of dialytic therapy, suggesting that HD is not a direct cause but that accumulation of β2M or some β2M-associated molecules in the body is a common pathogenesis...
June 12, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29881763/data-management-for-applications-of-patient-reported-outcomes
#4
E A Bayliss, H A Tabano, T M Gill, K Anzuoni, M Tai-Seale, H G Allore, D A Ganz, S Dublin, A L Gruber-Baldini, A L Adams, K M Mazor
Context: Patient reported outcomes (PROs) are one means of systematically gathering meaningful subjective information for patient care, population health, and patient centered outcomes research. However, optimal data management for effective PRO applications is unclear. Case description: Delivery systems associated with the Health Care Systems Research Network (HCSRN) have implemented PRO data collection as part of the Medicare annual Health Risk Assessment (HRA)...
May 10, 2018: EGEMS
https://www.readbyqxmd.com/read/29881215/activity-levels-following-hip-resurfacing-arthroplasty-a-tool-to-help-manage-patient-expectations
#5
Jack W Martin, Mark A Williams, Karen L Barker
Background: When compared to total hip arthroplasty (THA), hip resurfacing arthroplasty (HRA) is usually undertaken in younger, more active patients with hip osteoarthritis. Previous research has noted that patients are able to return to pre-operative activity levels, with many even increasing their activity post HRA, but patterns in post-operative recovery have been less well investigated. Materials and Methodology: A randomised controlled trial dataset was analysed to explore activity levels attained after HRA...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29869689/periprosthetic-acetabular-radiolucency-progression-in-mid-term-follow-up-of-the-articular-surface-replacement-hip-system
#6
Sean J Matuszak, Vincent P Galea, James W Connelly, Janus Christiansen, Orhun Muratoglu, Henrik Malchau
INTRODUCTION: Recent registry studies show that aseptic loosening secondary to osteolysis is the second leading cause of hip implant failure in patients implanted with metal-on-metal (MoM) bearings. The primary aim of our study was to report on the progression of acetabular osteolysis during mid-term follow-up in patients treated with MoM hip resurfacing arthroplasty (HRA) and MoM total hip arthroplasty (THA). The secondary aim was to identify independent predictors of osteolytic lesion progression...
June 5, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29862527/validation-of-a-brief-measure-of-hiv-health-related-anxiety-among-women-living-with-hiv
#7
Marya T Schulte, William D Marelich, Diana L Payne, Nicholas Tarantino, Lisa P Armistead, Debra A Murphy
Anxiety symptoms related to health are often present in populations coping with chronic illness, and among women living with HIV (WLWH), anxiety has been linked to a range of negative outcomes. This paper describes the validation of a four-item instrument designed to measure health-related anxiety (HRA) in WLWH by assessing the impact of thinking about HIV status and health on difficulty sleeping, lack of appetite, reduced desire to socialize, and difficulty concentrating at school or work. The scale was administered to 238 adult WLWH across three studies...
June 4, 2018: Research in Nursing & Health
https://www.readbyqxmd.com/read/29859090/impact-of-the-use-and-efficacy-of-long-lasting-insecticidal-net-on-malaria-infection-during-the-first-trimester-of-pregnancy-a-pre-conceptional-cohort-study-in-southern-benin
#8
Cornélia Hounkonnou, Armel Djènontin, Seun Egbinola, Parfait Houngbegnon, Aziz Bouraima, Christophe Soares, Nadine Fievet, Manfred Accrombessi, Emmanuel Yovo, Valérie Briand, Gilles Cottrell
BACKGROUND: Malaria in pregnancy is prevalent in Sub-Saharan Africa. The first trimester of pregnancy is a critical period and the best preventive measure is Long Lasting Insecticidal Nets (LLIN). Unfortunately, few studies have been conducted which focuses on the usage and efficacy of LLIN on malaria prevention during the first trimester. METHODS: We assessed the use and effectiveness of LLIN in early pregnancy in Benin and its impact on malaria infection risk...
June 1, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29844084/acute-macular-neuroretinopathy-pathogenetic-insights-from-optical-coherence-tomography-angiography
#9
Giuseppe Casalino, Alessandro Arrigo, Francesco Romano, Marion R Munk, Francesco Bandello, Maurizio Battaglia Parodi
AIM: To describe the optical coherence tomography angiography (OCT-A) features of patients affected by acute macular neuroretinopathy (AMN). METHODS: This is a prospective, observational, cross-sectional study. Multimodal imaging, including spectral domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany) and 6×6 mm swept source OCT-A (ZEISS PLEX Elite 9000; ZEISS, Dublin, California), was performed on all patients. The primary outcome measure was assessment of the vascular alterations of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC)...
May 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29780602/screening-for-colorectal-cancer-in-tianhe-guangzhou-results-of-combining-fecal-immunochemical-tests-and-risk-factors-for-selecting-patients-requiring-colonoscopy
#10
Yi Liao, Senmao Li, Chunyu Chen, Xuan He, Feng Lin, Jianping Wang, Zuli Yang, Ping Lan
Objective: To explore the performance of a protocol combining fecal immunochemical test (FIT) and a high-risk factor questionnaire (HRFQ) for selecting patients requiring colonoscopy as part of a population-based colorectal cancer (CRC) screening program in China. Methods: From 2015 to 2016, we conducted a CRC screening program for all residents aged 45 years or older in Tianhe District, Guangzhou City, China. Participants underwent an FIT and received an HRFQ as part of primary screening...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29772051/optical-coherence-tomography-angiography-of-pigmented-paravenous-retinochoroidal-atrophy
#11
Maria Vittoria Cicinelli, Chiara Giuffrè, Alessandro Rabiolo, Maurizio Battaglia Parodi, Francesco Bandello
A 58-year-old man with bilateral pigmented paravenous retinochoroidal atrophy (PPRCA) associated with macular coloboma in the right eye underwent color fundus photography and fundus autofluorescence with the California ultra-widefield retinal imaging system (Optos, Dunfermline, UK), spectral-domain optical coherence tomography (SD-OCT) (Heidelberg Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany), and en face OCT angiography (OCTA) (AngioPlex, Cirrus HD-OCT 5000; Carl Zeiss Meditec, Dublin, CA)...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29769257/optimum-hospice-at-home-services-for-end-of-life-care-protocol-of-a-mixed-methods-study-employing-realist-evaluation
#12
Claire Butler, Charlotte Brigden, Heather Gage, Peter Williams, Laura Holdsworth, Kay Greene, Bee Wee, Stephen Barclay, Patricia Wilson
INTRODUCTION: Hospice at home (HAH) services aim to enable patients to be cared for and die in their place of choice, if that is at home, and to achieve a 'good death'. There is a considerable range of HAH services operating in England. The published evidence focuses on evaluations of individual services which vary considerably, and there is a lack of consistency in terms of the outcome measures reported. The evidence, therefore, does not provide generalisable information, so the question 'What are the features of hospice at home service models that work, for whom, and under what circumstances?' remains unanswered...
May 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29753180/a-work-flow-to-build-and-validate-patient-specific-left-atrium-electrophysiology-models-from-catheter-measurements
#13
Cesare Corrado, Steven Williams, Rashed Karim, Gernot Plank, Mark O'Neill, Steven Niederer
Biophysical models of the atrium provide a physically constrained framework for describing the current state of an atrium and allow predictions of how that atrium will respond to therapy. We propose a work flow to simulate patient specific electrophysiological heterogeneity from clinical data and validate the resulting biophysical models. In 7 patients, we recorded the atrial anatomy with an electroanatomical mapping system (St Jude Velocity); we then applied an S1-S2 electrical stimulation protocol from the coronary sinus (CS) and the high right atrium (HRA) whilst recording the activation patterns using a PentaRay catheter with 10 bipolar electrodes at 12 ± 2 sites across the atrium...
April 27, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29750944/ellipsoid-zone-change-according-to-glaucoma-stage-advancement
#14
Ahnul Ha, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: Retinal photoreceptor ellipsoid zone (EZ) intensity comparison between normal eyes and those with different stages of glaucoma. DESIGN: Retrospective cross-sectional study METHODS: The study included 37 normal, 38 pre-perimetric, 39 mild-to-moderate (visual field [VF] mean deviation [MD]: -7.7±2.0 dB), and 36 severe glaucoma eyes (VF MD: -17.8±3.2 dB). The subjects underwent high-resolution horizontal and vertical-line scans through the fovea by spectral-domain optical coherence tomography [SD-OCT] (Spectralis HRA+OCT; Heidelberg)...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29747610/the-acceptability-of-high-resolution-anoscopy-examination-in-patients-attending-a-tertiary-referral-centre
#15
Anke De-Masi, Esther Davis, Tamzin Cuming, Noreen Chindawi, Francesca Pesola, Carmelina Cappello, Susan Chambers, Julie Bowring, Adam N Rosenthal, Peter Sasieni, Mayura Nathan
BACKGROUND: High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination and ablative treatment under local anaesthetic. METHODS: Patients took part in anonymised feedback of their experience immediately after their HRA examinations and/or treatments...
May 11, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29743373/five-residues-in-the-apical-loop-of-the-respiratory-syncytial-virus-fusion-protein-f-2-subunit-are-critical-for-its-fusion-activity
#16
Stephanie N Hicks, Supranee Chaiwatpongsakorn, Heather M Costello, Jason S McLellan, William Ray, Mark E Peeples
The respiratory syncytial virus (RSV) fusion (F) protein is a trimeric, membrane-anchored glycoprotein capable of mediating both viral-target cell membrane fusion to initiate infection and cell-cell fusion, even in the absence of the attachment glycoprotein. The F protein is initially expressed in a precursor form, whose functional capabilities are activated by proteolysis at two sites between the F1 and F2 subunits. This cleavage results in expression of the metastable and high-energy prefusion conformation...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29736750/a-coaching-by-telephone-intervention-on-engaging-patients-to-address-modifiable-cardiovascular-risk-factors-a-randomized-controlled-trial
#17
Eugene Z Oddone, Jennifer M Gierisch, Linda L Sanders, Angela Fagerlin, Jordan Sparks, Felicia McCant, Carrie May, Maren K Olsen, Laura J Damschroder
BACKGROUND: A large proportion of deaths and chronic illnesses can be attributed to three modifiable risk factors: tobacco use, overweight/obesity, and physical inactivity. OBJECTIVE: To test whether telephone-based health coaching after completion of a comprehensive health risk assessment (HRA) increases patient activation and enrollment in a prevention program compared to HRA completion alone. DESIGN: Two-arm randomized trial at three sites...
May 7, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29716436/efficacy-of-cladribine-tablets-in-high-disease-activity-subgroups-of-patients-with-relapsing-multiple-sclerosis-a-post-hoc-analysis-of-the-clarity-study
#18
Gavin Giovannoni, Per Soelberg Sorensen, Stuart Cook, Kottil W Rammohan, Peter Rieckmann, Giancarlo Comi, Fernando Dangond, Christine Hicking, Patrick Vermersch
BACKGROUND: In the CLARITY (CLAdRIbine Tablets treating multiple sclerosis orallY) study, Cladribine Tablets significantly improved clinical and magnetic resonance imaging (MRI) outcomes (vs placebo) in patients with relapsing-remitting multiple sclerosis. OBJECTIVE: Describe two clinically relevant definitions for patients with high disease activity (HDA) at baseline of the CLARITY study (utility verified in patients receiving placebo) and assess the treatment effects of Cladribine Tablets 3...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29699784/smartphone-app-uses-loyalty-point-incentives-and-push-notifications-to-encourage-influenza-vaccine-uptake
#19
Leila Pfaeffli Dale, Lauren White, Marc Mitchell, Guy Faulkner
PURPOSE: Carrot Rewards is a free, incentive-based, smartphone health app available in participating provinces in Canada. One feature of Carrot was designed to incentivize influenza vaccine education messages and encourage vaccine uptake for users in the province of British Columbia. This study aimed to evaluate the uptake of the Carrot Flu Campaign educational quiz and to determine if mobile "push" notifications, plus loyalty point incentives, resulted in users visiting a sponsored pharmacy to discuss and receive the influenza vaccine...
April 23, 2018: Vaccine
https://www.readbyqxmd.com/read/29681866/study-protocol-using-deep-brain-stimulation-multimodal-neuroimaging-and-neuroethics-to-understand-and-treat-severe-enduring-anorexia-nervosa
#20
Rebecca J Park, Jessica C Scaife, Tipu Z Aziz
Background: Research suggests that altered eating and the pursuit of thinness in anorexia nervosa (AN) are, in part, a consequence of aberrant reward circuitry. The neural circuits involved in reward processing and compulsivity overlap significantly, and this has been suggested as a transdiagnostic factor underpinning obsessive compulsive disorder, addictions and eating disorders. The nucleus accumbens (NAcc) is central to both reward processing and compulsivity. In previous studies, deep-brain stimulation (DBS) to the NAcc has been shown to result in neural and symptomatic improvement in both obsessive compulsive disorder and addictions...
2018: Frontiers in Psychiatry
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