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https://www.readbyqxmd.com/read/27862461/single-electron-transfer-between-cux2-and-thiols-determined-by-extended-x-ray-absorption-fine-structure-analysis-application-in-markovnikov-type-hydrothiolation-of-styrenes
#1
Hong Yi, Chunlan Song, Yiying Li, Chih-Wen Pao, Jyh-Fu Lee, Aiwen Lei
Transition-metal mediated C-S bond formation using thiol compounds has been widely used in recent years. However, there has been less focus on the interaction between the metal and thiol compounds. In this work, we have successfully evidenced the single-electron transfer between CuX2 and thiophenol utilizing EXAFS. The fitting EXAFS results reveal that two halide anions are coordinated with the Cu(I) center, whereas no sulfur atom is observed in the first coordination sphere. This Cu(I) ate complex serves as the key intermediate for the proton transfer in the application of Markovnikov-type hydrothiolation reactions...
November 10, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27590341/special-at-rich-sequence-binding-protein-1-satb1-functions-as-an-accessory-factor-in-base-excision-repair
#2
Simran Kaur, Yan Coulombe, Zubaidah M Ramdzan, Lam Leduy, Jean-Yves Masson, Alain Nepveu
Base excision repair is initiated by DNA glycosylases that recognize specific altered bases. DNA glycosylases for oxidized bases carry both a glycosylase activity that removes the faulty base and an apyrimidinic/apurinic lyase activity that introduces a single-strand DNA incision. In particular, the CUT domains within the CUX1 and CUX2 proteins were recently shown to interact with the 8-oxoguanine (8-oxoG) DNA glycosylase and stimulate its enzymatic activities. SATB1, which contains two CUT domains, was originally characterized as a T cell-specific genome organizer whose aberrant overexpression in breast cancer can promote tumor progression...
October 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27466782/the-control-of-the-electronic-structure-of-dinuclear-copper-complexes-of-redox-active-tetrakisguanidine-ligands-by-the-environment
#3
Sven Wiesner, Arne Wagner, Elisabeth Kaifer, Hans-Jörg Himmel
The electronic structures of dinuclear copper complexes of the general formula [GFA(CuX2)2], where X = Br or Cl and GFA denotes a redox-active bridging Guanidino-Functionalized Aromatic ligand, were analysed and compared. The diamagnetic complexes [GFA(CuBr2)2] can all be described as dinuclear Cu(I) complexes with bridging GFA(2+) dicationic ligand units exhibiting a [Cu(I)-GFA(2+)-Cu(I)] electronic structure. The electronic structure prevails in the solid state and in all applicable organic solvents. The situation changes completely for the [GFA(CuCl2)2] complexes...
October 12, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27314648/peroxide-free-pd-ii-catalyzed-ortho-aroylation-and-ortho-halogenation-of-directing-arenes
#4
Sourav Kumar Santra, Arghya Banerjee, Prakash Ranjan Mohanta, Bhisma K Patel
A Pd(II)-catalyzed peroxide-free ortho aroylation of directing arenes has been developed via cross dehydrogenative coupling (CDC) in the presence of the terminal oxidant Cu(OAc)2·H2O. Ortho aroylation of directing arenes proceeds via decarbonylation of the in situ generated phenyl glyoxal, which is obtained from 2-acetoxyacetophenone in the presence of the oxidant Cu(OAc)2·H2O. However, changing the oxidant to CuX2 (X = Cl, Br) provided exclusive di-ortho-halogenated 2-arylbenzothiazoles. During the halogenation, CuX2 served the dual role of a halogen source as well as a co-oxidant...
July 15, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27198720/cux2-serves-as-a-novel-lineage-marker-of-granule-cell-layer-neurons-from-the-rhombic-lip-in-mouse-and-chick-embryos
#5
Emily Capaldo, Angelo Iulianella
BACKGROUND: The rhombic lip (RL), a germinal zone in the developing hindbrain, gives rise to all of the excitatory neurons of the cerebellum. It is presently unclear what factors distinguish between RL progenitor pools and play a role in differentiating the multiple cell types that arise from this region. The transcription factor Cux2 has been shown to play important roles in proliferation and differentiation of distinct neuronal populations during embryogenesis, but its role in cerebellar fate restriction is unknown...
August 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27181629/identification-of-rs671-a-common-variant-of-aldh2-as-a-gout-susceptibility-locus
#6
Masayuki Sakiyama, Hirotaka Matsuo, Hirofumi Nakaoka, Ken Yamamoto, Akiyoshi Nakayama, Takahiro Nakamura, Sayo Kawai, Rieko Okada, Hiroshi Ooyama, Toru Shimizu, Nariyoshi Shinomiya
Gout is a common disease resulting from hyperuricemia. Recently, a genome-wide association study identified an association between gout and a single nucleotide polymorphism (SNP) rs2188380, located on an intergenic region between MYL2 and CUX2 on chromosome 12. However, other genes around rs2188380 could possibly be gout susceptibility genes. Therefore, we performed a fine-mapping study of the MYL2-CUX2 region. From 8,595 SNPs in the MYL2-CUX2 region, 9 tag SNPs were selected, and genotyping of 1,048 male gout patients and 1,334 male controls was performed by TaqMan method...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27098836/in-situ-hybridization-analyses-of-claustrum-enriched-genes-in-marmosets
#7
Akiya Watakabe
Claustrum and endopiriform nucleus are unique structures that sit between the striatum and the cerebral cortex. Recent genome-wide mapping of gene expression in mice identified various genes concentrated in this structure, suggesting a requirement for a special set of genes for its function. In this paper, I performed in situ hybridization histochemistry (ISH) of such "claustrum-enriched" genes in the marmoset brain. In marmosets, nurr1 and netrinG2 genes exhibited highly concentrated expression in the claustrum and endopiriform nucleus, as well as in a subpopulation of layer 6 neurons across the entire cortex, consistent with their expression patterns as described in macaques...
April 21, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27042238/specific-pattern-of-maturation-and-differentiation-in-the-formation-of-cortical-tubers-in-tuberous-sclerosis-omplex-tsc-evidence-from-layer-specific-marker-expression
#8
Angelika Mühlebner, Anand M Iyer, Jackelien van Scheppingen, Jasper J Anink, Floor E Jansen, Tim J Veersema, Kees P Braun, Wim G M Spliet, Wim van Hecke, Figen Söylemezoğlu, Martha Feucht, Pavel Krsek, Josef Zamecnik, Christian G Bien, Tilman Polster, Roland Coras, Ingmar Blümcke, Eleonora Aronica
BACKGROUND: Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations in the TSC1 or TSC2 genes, leading to constitutive activation of the mammalian target of rapamycin (mTOR) signaling pathway. Cortical tubers represent typical lesions of the central nervous system (CNS) in TSC. The pattern of cortical layering disruption observed in brain tissue of TSC patients is not yet fully understood, and little is known about the origin and phenotype of individual abnormal cell types recognized in tubers...
2016: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/26477859/counter-ligand-control-of-the-electronic-structure-in-dinuclear-copper-tetrakisguanidine-complexes
#9
Alexandra Ziesak, Tobias Wesp, Olaf Hübner, Elisabeth Kaifer, Hubert Wadepohl, Hans-Jörg Himmel
The redox-active GFA (Guanidino-Functionalized Aromatic compound) 1,4,5,8-tetrakis(tetramethylguanidino)-naphthalene (6) is used to synthesize new dinuclear copper complexes of the formula [6(CuX2)2] with different electronic structures. With X = OAc, a dinuclear Cu(II) complex of the neutral GFA is obtained (electronic structure [Cu(II)-GFA-Cu(II)], two unpaired electrons), and with X = Br a diamagnetic dinuclear Cu(I) complex of the dicationic GFA (electronic structure [Cu(I)-GFA(2+)-Cu(I)], closed-shell singlet state)...
November 28, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/26459762/hepatic-long-intergenic-noncoding-rnas-high-promoter-conservation-and-dynamic-sex-dependent-transcriptional-regulation-by-growth-hormone
#10
Tisha Melia, Pengying Hao, Feyza Yilmaz, David J Waxman
Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as key chromatin regulators, yet few studies have characterized lincRNAs in a single tissue under diverse conditions. Here, we analyzed 45 mouse liver RNA sequencing (RNA-Seq) data sets collected under diverse conditions to systematically characterize 4,961 liver lincRNAs, 59% of them novel, with regard to gene structures, species conservation, chromatin accessibility, transcription factor binding, and epigenetic states. To investigate the potential for functionality, we focused on the responses of the liver lincRNAs to growth hormone stimulation, which imparts clinically relevant sex differences to hepatic metabolism and liver disease susceptibility...
January 1, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/26221032/cux2-protein-functions-as-an-accessory-factor-in-the-repair-of-oxidative-dna-damage
#11
Ranjana Pal, Zubaidah M Ramdzan, Simran Kaur, Philippe M Duquette, Richard Marcotte, Lam Leduy, Sayeh Davoudi, Nathalie Lamarche-Vane, Angelo Iulianella, Alain Nepveu
CUX1 and CUX2 proteins are characterized by the presence of three highly similar regions called Cut repeats 1, 2, and 3. Although CUX1 is ubiquitously expressed, CUX2 plays an important role in the specification of neuronal cells and continues to be expressed in postmitotic neurons. Cut repeats from the CUX1 protein were recently shown to stimulate 8-oxoguanine DNA glycosylase 1 (OGG1), an enzyme that removes oxidized purines from DNA and introduces a single strand break through its apurinic/apyrimidinic lyase activity to initiate base excision repair...
September 11, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26218442/cross-talk-between-gh-regulated-transcription-factors-hnf6-and-cux2-in-adult-mouse-liver
#12
Tara L Conforto, George F Steinhardt, David J Waxman
Hepatocyte-enriched nuclear factor (HNF)6 and CUX2 are GH and STAT5-regulated homeobox transcription factors. CUX2 shows female-specific expression and contributes to liver sex differences by repressing many male-biased genes and inducing many female-biased genes, whereas HNF6 is expressed at similar levels in male and female liver. In cell-based transfection studies, CUX2 inhibited HNF6 transcriptional regulation of the sex-specific gene promoters CYP2C11 and CYP2C12, blocking HNF6 repression of CYP2C11 and HNF6 activation of CYP2C12...
September 2015: Molecular Endocrinology
https://www.readbyqxmd.com/read/26043187/synthesis-and-reactions-of-3d-metal-complexes-with-the-bulky-alkoxide-ligand-oc-t-bu2ph
#13
James A Bellow, Maryam Yousif, Dong Fang, Eric G Kratz, G Andrés Cisneros, Stanislav Groysman
Treatment of NiCl2(dme) and NiBr2(dme) (dme = dimethoxyethane) with 2 equiv of LiOR (OR = OC(t)Bu2Ph) forms the distorted trigonal planar complexes [NiLiX(OR)2(THF)2] (THF = tetrahydrofuran) 5 (X = Cl) and 6 (X = Br). The reaction of CuX2 (X = Cl, Br) with 2 equiv of LiOR affords the Cu(I) product Cu4(OR)4 (7). The same product can be obtained using the Cu(I) starting material CuCl. NMR studies indicated that the reduction of Cu(II) to Cu(I) is accompanied by the oxidation of the alkoxide RO(-) to form the alkoxy radical RO(•), which subsequently forms tert-butyl phenyl ketone by β-scission...
June 15, 2015: Inorganic Chemistry
https://www.readbyqxmd.com/read/26007699/cux-2-mediated-oxybromination-aminochlorination-of-unsaturated-amides-synthesis-of-iminolactones-and-lactams
#14
Zhi-Qiang Zhang, Feng Liu
We report herein a CuX2-mediated halocyclization of γ,δ-unsaturated amides for the synthesis of functionalized iminolactones and lactams respectively under mild reaction conditions. Mechanism studies indicated that N-attack cyclization was via a radical route while oxycyclization was via a nucleophilic attack on the activated C=C bond.
June 28, 2015: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/25996137/cux2-positive-radial-glial-cells-generate-diverse-subtypes-of-neocortical-projection-neurons-and-macroglia
#15
Matthew J Eckler, Ton D Nguyen, William L McKenna, Ben L Fastow, Chao Guo, John L R Rubenstein, Bin Chen
We recently published genetic lineage-tracing experiments using the Fezf2 and Cux2 loci. These experiments demonstrated that at both the clonal and population levels Fezf2(+) RGCs are multipotent and that at the population level Cux2(+) RGCs are multipotent. Here, we extend our work on the lineages of Fezf2(+) and Cux2(+) RGCs. Clonal analysis of E10.5 neocortical progenitors suggests that most, if not all, Cux2(+) and Fezf2(+) RGCs generate diverse projection neuron subtypes located throughout layers 2-6. These results support our previous conclusion that both Fezf2(+) and Cux2(+) RGCs are multipotent neocortical progenitors...
May 20, 2015: Neuron
https://www.readbyqxmd.com/read/25996136/lineage-tracing-using-cux2-cre-and-cux2-creert2-mice
#16
Cristina Gil-Sanz, Ana Espinosa, Santiago P Fregoso, Krista K Bluske, Christopher L Cunningham, Isabel Martinez-Garay, Hongkui Zeng, Santos J Franco, Ulrich Müller
Using genetic fate-mapping with Cux2-Cre and Cux2-CreERT2 mice we demonstrated that the neocortical ventricular zone (VZ) contains radial glial cells (RGCs) with restricted fate potentials (Franco et al., 2012). Using the same mouse lines, Guo et al. (2013) concluded that the neocortical VZ does not contain lineage-restricted RGCs. We now show that the recombination pattern in Cux2-Cre/CreERT2 mice depends on genetic background and breeding strategies. We provide evidence that Guo et al. likely reached different conclusions because they worked with transgenic sublines with drifted transgene expression patterns...
May 20, 2015: Neuron
https://www.readbyqxmd.com/read/25661753/%C3%AF-rich-%C3%AF-2-p-heterocycles-bent-%C3%AE-1-p-and-%C3%AE-2-p-coordinated-1-3-benzazaphosphole-copper-i-halide-complexes
#17
Mohammed Ghalib, Peter G Jones, Carola Schulzke, Dénes Sziebert, László Nyulászi, Joachim W Heinicke
The reaction of 1-neopentyl-1,3-benzazaphosphole 1 with CuCl, CuBr, or Cu(SMe2)Br in THF at room temperature provides sparingly soluble [Cu7(μ(2)-L6)(μ(2)-X7)](+)[CuX2](-) cluster complexes 2a,b (L indicates coordinated 1, a X = Cl, b X = Br), with loosely bound THF, in high yields. The conversions proceed via transient THF-soluble labile [(L2CuX)2] complexes. Separation before complete conversion, combined with suitable conditions for crystallization, allowed these intermediates to be trapped. Depending on the reactant ratios, crystals of the clusters or of dimeric L2CuX complexes were formed...
March 2, 2015: Inorganic Chemistry
https://www.readbyqxmd.com/read/25646370/genome-wide-association-study-of-clinically-defined-gout-identifies-multiple-risk-loci-and-its-association-with-clinical-subtypes
#18
Hirotaka Matsuo, Ken Yamamoto, Hirofumi Nakaoka, Akiyoshi Nakayama, Masayuki Sakiyama, Toshinori Chiba, Atsushi Takahashi, Takahiro Nakamura, Hiroshi Nakashima, Yuzo Takada, Inaho Danjoh, Seiko Shimizu, Junko Abe, Yusuke Kawamura, Sho Terashige, Hiraku Ogata, Seishiro Tatsukawa, Guang Yin, Rieko Okada, Emi Morita, Mariko Naito, Atsumi Tokumasu, Hiroyuki Onoue, Keiichi Iwaya, Toshimitsu Ito, Tappei Takada, Katsuhisa Inoue, Yukio Kato, Yukio Nakamura, Yutaka Sakurai, Hiroshi Suzuki, Yoshikatsu Kanai, Tatsuo Hosoya, Nobuyuki Hamajima, Ituro Inoue, Michiaki Kubo, Kimiyoshi Ichida, Hiroshi Ooyama, Toru Shimizu, Nariyoshi Shinomiya
OBJECTIVE: Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide association studies (GWASs) of gout have been reported, they included self-reported gout cases in which clinical information was insufficient. Therefore, the relationship between genetic variation and clinical subtypes of gout remains unclear. Here, we first performed a GWAS of clinically defined gout cases only. METHODS: A GWAS was conducted with 945 patients with clinically defined gout and 1213 controls in a Japanese male population, followed by replication study of 1048 clinically defined cases and 1334 controls...
April 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/25252086/cux2-activity-defines-a-subpopulation-of-perinatal-neurogenic-progenitors-in-the-hippocampus
#19
Makiko Yamada, Jessica Clark, Christine McClelland, Emily Capaldo, Ayush Ray, Angelo Iulianella
The hippocampus arises from the medial region of the subventricular (SVZ) within the telencephalon. It is one of two regions in the postnatal brain that harbors neural progenitors (NPs) capable of giving rise to new neurons. Neurogenesis in the hippocampus is restricted to the subgranular zone (SGZ) of the dentate gyrus (DG) where it contributes to the generation of granule cell layer (gcl) neurons. It is thought that SGZ progenitors are heterogeneous, differing in their morphology, expression profiles, and developmental potential, however it is currently unknown whether they display differences in their developmental origins and cell fate-restriction in the DG...
February 2015: Hippocampus
https://www.readbyqxmd.com/read/25124494/integrating-genetic-transcriptional-and-functional-analyses-to-identify-5-novel-genes-for-atrial-fibrillation
#20
COMPARATIVE STUDY
Moritz F Sinner, Nathan R Tucker, Kathryn L Lunetta, Kouichi Ozaki, J Gustav Smith, Stella Trompet, Joshua C Bis, Honghuang Lin, Mina K Chung, Jonas B Nielsen, Steven A Lubitz, Bouwe P Krijthe, Jared W Magnani, Jiangchuan Ye, Michael H Gollob, Tatsuhiko Tsunoda, Martina Müller-Nurasyid, Peter Lichtner, Annette Peters, Elena Dolmatova, Michiaki Kubo, Jonathan D Smith, Bruce M Psaty, Nicholas L Smith, J Wouter Jukema, Daniel I Chasman, Christine M Albert, Yusuke Ebana, Tetsushi Furukawa, Peter W Macfarlane, Tamara B Harris, Dawood Darbar, Marcus Dörr, Anders G Holst, Jesper H Svendsen, Albert Hofman, Andre G Uitterlinden, Vilmundur Gudnason, Mitsuaki Isobe, Rainer Malik, Martin Dichgans, Jonathan Rosand, David R Van Wagoner, Emelia J Benjamin, David J Milan, Olle Melander, Susan R Heckbert, Ian Ford, Yongmei Liu, John Barnard, Morten S Olesen, Bruno H C Stricker, Toshihiro Tanaka, Stefan Kääb, Patrick T Ellinor
BACKGROUND: Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic basis for the arrhythmia remains incompletely understood. METHODS AND RESULTS: To identify new AF-related genes, we used a multifaceted approach, combining large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative trait loci) mapping, and functional validation...
October 7, 2014: Circulation
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