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https://www.readbyqxmd.com/read/28922406/loss-of-liver-specific-and-sexually-dimorphic-gene-expression-by-aryl-hydrocarbon-receptor-activation-in-c57bl-6-mice
#1
Rance Nault, Kelly A Fader, Jack R Harkema, Tim Zacharewski
The aryl hydrocarbon receptor (AhR) is a highly conserved transcription factor that mediates a broad spectrum of species-, strain-, sex-, age-, tissue-, and cell-specific responses elicited by structurally diverse ligands including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Dose-dependent effects on liver-specific and sexually dimorphic gene expression were examined in male and female mice gavaged with TCDD every 4 days for 28 or 92 days. RNA-seq data revealed the coordinated repression of 181 genes predominately expressed in the liver including albumin (3...
2017: PloS One
https://www.readbyqxmd.com/read/28694329/feminization-of-male-mouse-liver-by-persistent-growth-hormone-stimulation-activation-of-sex-biased-transcriptional-networks-and-dynamic-changes-in-chromatin-states
#2
Dana Lau-Corona, Alexander Suvorov, David J Waxman
Sex-dependent pituitary GH secretory profiles--pulsatile in males and persistent in females--regulate sex-biased, STAT5-dependent expression of hundreds of genes in mouse liver, imparting sex differences in hepatic drug/lipid metabolism and disease risk. Here we examine transcriptional and epigenetic changes induced by continuous-GH infusion (cGH) in male mice, which rapidly feminizes the temporal profile of liver STAT5 activity. cGH repressed 86% of male-biased genes and induced 68% of female-biased genes within 4-days; however, several highly female-specific genes showed weak or no feminization, even after 14-days cGH...
July 10, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28300072/unravelling-the-hidden-link-of-lithium-halides-and-application-in-the-synthesis-of-organocuprates
#3
Hong Yi, Dali Yang, Jie Xin, Xiaotian Qi, Yu Lan, Yi Deng, Chih-Wen Pao, Jyh-Fu Lee, Aiwen Lei
As a versatile metal, copper has demonstrated a wide application in acting as both organometallic reagent and catalyst. Organocuprates are among the most used organometallic reagents in the formation of new carbon-carbon bonds in organic synthesis. Therefore, revealing the real structures of organocuprates in solution is crucial to provide insights into the reactivity of organocuprates. Here we provide several important insights into organocuprate chemistry. The main finding contains the following aspects. The Cu(0) particles were detected via the reduction of CuX by nBuLi or PhLi...
March 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28177030/infrared-spectroscopic-study-of-absorption-and-separation-of-co-using-copper-i-containing-ionic-liquids
#4
Stephen E Repper, Anthony Haynes, Evert J Ditzel, Glenn J Sunley
Absorption of carbon monoxide by copper(i)-containing ionic liquids, [Cnmim][CuX2] (Cnmim = 1-alkyl-3-methylimidazolium, n = 2, 4, 6, X = Cl, Br, I) has been investigated using in situ high pressure infrared spectroscopy. For each liquid, observation of a ν(CO) band in the region 2075-2090 cm(-1) indicates the formation of copper(i) monocarbonyl complexes, assigned as [Cu(CO)X2](-). The rate of growth and equilibrium intensity of the ν(CO) absorption is dependent on applied CO pressure. Binding of CO is reversible such that complete desorption occurs rapidly on heating above 100 °C and the liquids are robust over multiple gas absorption/desorption cycles...
February 8, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28129963/genetic-variants-associated-with-susceptibility-to-atrial-fibrillation-in-a-japanese-population
#5
MULTICENTER STUDY
Lian Liu, Yusuke Ebana, Jun-Ichi Nitta, Yoshihide Takahashi, Shinsuke Miyazaki, Toshihiro Tanaka, Masatoshi Komura, Mitsuaki Isobe, Tetsushi Furukawa
BACKGROUND: Atrial fibrillation (AF) affects millions of individuals worldwide. The genome-wide association studies have identified robust genetic associations with AF. METHODS: We genotyped 5461 participants of Japanese ancestry for 11 AF-related loci and determined the effects of carrying different numbers of risk alleles on disease development and age at disease onset. The weighted genetic risk score (GRS) was calculated, and its ability to predict AF was determined...
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28067321/methylome-wide-association-study-of-atrial-fibrillation-in-framingham-heart-study
#6
Honghuang Lin, Xiaoyan Yin, Zhijun Xie, Kathryn L Lunetta, Steven A Lubitz, Martin G Larson, Darae Ko, Jared W Magnani, Michael M Mendelson, Chunyu Liu, David D McManus, Daniel Levy, Patrick T Ellinor, Emelia J Benjamin
Atrial fibrillation (AF) is the most common cardiac arrhythmia, but little is known about the molecular mechanisms associated with AF arrhythmogenesis. DNA methylation is an important epigenetic mechanism that regulates gene expression and downstream biological processes. We hypothesize that DNA methylation might play an important role in the susceptibility to develop AF. A total of 2,639 participants from the Offspring Cohort of Framingham Heart Study were enrolled in the current study. These participants included 183 participants with prevalent AF and 220 with incident AF during up to 9 years follow up...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27862461/single-electron-transfer-between-cux2-and-thiols-determined-by-extended-x-ray-absorption-fine-structure-analysis-application-in-markovnikov-type-hydrothiolation-of-styrenes
#7
Hong Yi, Chunlan Song, Yiying Li, Chih-Wen Pao, Jyh-Fu Lee, Aiwen Lei
Transition-metal mediated C-S bond formation using thiol compounds has been widely used in recent years. However, there has been less focus on the interaction between the metal and thiol compounds. In this work, we have successfully evidenced the single-electron transfer between CuX2 and thiophenol utilizing EXAFS. The fitting EXAFS results reveal that two halide anions are coordinated with the Cu(I) center, whereas no sulfur atom is observed in the first coordination sphere. This Cu(I) ate complex serves as the key intermediate for the proton transfer in the application of Markovnikov-type hydrothiolation reactions...
December 19, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27590341/special-at-rich-sequence-binding-protein-1-satb1-functions-as-an-accessory-factor-in-base-excision-repair
#8
Simran Kaur, Yan Coulombe, Zubaidah M Ramdzan, Lam Leduy, Jean-Yves Masson, Alain Nepveu
Base excision repair is initiated by DNA glycosylases that recognize specific altered bases. DNA glycosylases for oxidized bases carry both a glycosylase activity that removes the faulty base and an apyrimidinic/apurinic lyase activity that introduces a single-strand DNA incision. In particular, the CUT domains within the CUX1 and CUX2 proteins were recently shown to interact with the 8-oxoguanine (8-oxoG) DNA glycosylase and stimulate its enzymatic activities. SATB1, which contains two CUT domains, was originally characterized as a T cell-specific genome organizer whose aberrant overexpression in breast cancer can promote tumor progression...
October 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27466782/the-control-of-the-electronic-structure-of-dinuclear-copper-complexes-of-redox-active-tetrakisguanidine-ligands-by-the-environment
#9
Sven Wiesner, Arne Wagner, Elisabeth Kaifer, Hans-Jörg Himmel
The electronic structures of dinuclear copper complexes of the general formula [GFA(CuX2)2], where X = Br or Cl and GFA denotes a redox-active bridging Guanidino-Functionalized Aromatic ligand, were analysed and compared. The diamagnetic complexes [GFA(CuBr2)2] can all be described as dinuclear Cu(I) complexes with bridging GFA(2+) dicationic ligand units exhibiting a [Cu(I)-GFA(2+)-Cu(I)] electronic structure. The electronic structure prevails in the solid state and in all applicable organic solvents. The situation changes completely for the [GFA(CuCl2)2] complexes...
October 12, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27314648/peroxide-free-pd-ii-catalyzed-ortho-aroylation-and-ortho-halogenation-of-directing-arenes
#10
Sourav Kumar Santra, Arghya Banerjee, Prakash Ranjan Mohanta, Bhisma K Patel
A Pd(II)-catalyzed peroxide-free ortho aroylation of directing arenes has been developed via cross dehydrogenative coupling (CDC) in the presence of the terminal oxidant Cu(OAc)2·H2O. Ortho aroylation of directing arenes proceeds via decarbonylation of the in situ generated phenyl glyoxal, which is obtained from 2-acetoxyacetophenone in the presence of the oxidant Cu(OAc)2·H2O. However, changing the oxidant to CuX2 (X = Cl, Br) provided exclusive di-ortho-halogenated 2-arylbenzothiazoles. During the halogenation, CuX2 served the dual role of a halogen source as well as a co-oxidant...
July 15, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27198720/cux2-serves-as-a-novel-lineage-marker-of-granule-cell-layer-neurons-from-the-rhombic-lip-in-mouse-and-chick-embryos
#11
Emily Capaldo, Angelo Iulianella
BACKGROUND: The rhombic lip (RL), a germinal zone in the developing hindbrain, gives rise to all of the excitatory neurons of the cerebellum. It is presently unclear what factors distinguish between RL progenitor pools and play a role in differentiating the multiple cell types that arise from this region. The transcription factor Cux2 has been shown to play important roles in proliferation and differentiation of distinct neuronal populations during embryogenesis, but its role in cerebellar fate restriction is unknown...
August 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27181629/identification-of-rs671-a-common-variant-of-aldh2-as-a-gout-susceptibility-locus
#12
Masayuki Sakiyama, Hirotaka Matsuo, Hirofumi Nakaoka, Ken Yamamoto, Akiyoshi Nakayama, Takahiro Nakamura, Sayo Kawai, Rieko Okada, Hiroshi Ooyama, Toru Shimizu, Nariyoshi Shinomiya
Gout is a common disease resulting from hyperuricemia. Recently, a genome-wide association study identified an association between gout and a single nucleotide polymorphism (SNP) rs2188380, located on an intergenic region between MYL2 and CUX2 on chromosome 12. However, other genes around rs2188380 could possibly be gout susceptibility genes. Therefore, we performed a fine-mapping study of the MYL2-CUX2 region. From 8,595 SNPs in the MYL2-CUX2 region, 9 tag SNPs were selected, and genotyping of 1,048 male gout patients and 1,334 male controls was performed by TaqMan method...
May 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27098836/in-situ-hybridization-analyses-of-claustrum-enriched-genes-in-marmosets
#13
Akiya Watakabe
Claustrum and endopiriform nucleus are unique structures that sit between the striatum and the cerebral cortex. Recent genome-wide mapping of gene expression in mice identified various genes concentrated in this structure, suggesting a requirement for a special set of genes for its function. In this paper, I performed in situ hybridization histochemistry (ISH) of such "claustrum-enriched" genes in the marmoset brain. In marmosets, nurr1 and netrinG2 genes exhibited highly concentrated expression in the claustrum and endopiriform nucleus, as well as in a subpopulation of layer 6 neurons across the entire cortex, consistent with their expression patterns as described in macaques...
April 21, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27042238/specific-pattern-of-maturation-and-differentiation-in-the-formation-of-cortical-tubers-in-tuberous-sclerosis-omplex-tsc-evidence-from-layer-specific-marker-expression
#14
Angelika Mühlebner, Anand M Iyer, Jackelien van Scheppingen, Jasper J Anink, Floor E Jansen, Tim J Veersema, Kees P Braun, Wim G M Spliet, Wim van Hecke, Figen Söylemezoğlu, Martha Feucht, Pavel Krsek, Josef Zamecnik, Christian G Bien, Tilman Polster, Roland Coras, Ingmar Blümcke, Eleonora Aronica
BACKGROUND: Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations in the TSC1 or TSC2 genes, leading to constitutive activation of the mammalian target of rapamycin (mTOR) signaling pathway. Cortical tubers represent typical lesions of the central nervous system (CNS) in TSC. The pattern of cortical layering disruption observed in brain tissue of TSC patients is not yet fully understood, and little is known about the origin and phenotype of individual abnormal cell types recognized in tubers...
2016: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/26477859/counter-ligand-control-of-the-electronic-structure-in-dinuclear-copper-tetrakisguanidine-complexes
#15
Alexandra Ziesak, Tobias Wesp, Olaf Hübner, Elisabeth Kaifer, Hubert Wadepohl, Hans-Jörg Himmel
The redox-active GFA (Guanidino-Functionalized Aromatic compound) 1,4,5,8-tetrakis(tetramethylguanidino)-naphthalene (6) is used to synthesize new dinuclear copper complexes of the formula [6(CuX2)2] with different electronic structures. With X = OAc, a dinuclear Cu(II) complex of the neutral GFA is obtained (electronic structure [Cu(II)-GFA-Cu(II)], two unpaired electrons), and with X = Br a diamagnetic dinuclear Cu(I) complex of the dicationic GFA (electronic structure [Cu(I)-GFA(2+)-Cu(I)], closed-shell singlet state)...
November 28, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/26459762/hepatic-long-intergenic-noncoding-rnas-high-promoter-conservation-and-dynamic-sex-dependent-transcriptional-regulation-by-growth-hormone
#16
Tisha Melia, Pengying Hao, Feyza Yilmaz, David J Waxman
Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as key chromatin regulators, yet few studies have characterized lincRNAs in a single tissue under diverse conditions. Here, we analyzed 45 mouse liver RNA sequencing (RNA-Seq) data sets collected under diverse conditions to systematically characterize 4,961 liver lincRNAs, 59% of them novel, with regard to gene structures, species conservation, chromatin accessibility, transcription factor binding, and epigenetic states. To investigate the potential for functionality, we focused on the responses of the liver lincRNAs to growth hormone stimulation, which imparts clinically relevant sex differences to hepatic metabolism and liver disease susceptibility...
January 1, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/26221032/cux2-protein-functions-as-an-accessory-factor-in-the-repair-of-oxidative-dna-damage
#17
Ranjana Pal, Zubaidah M Ramdzan, Simran Kaur, Philippe M Duquette, Richard Marcotte, Lam Leduy, Sayeh Davoudi, Nathalie Lamarche-Vane, Angelo Iulianella, Alain Nepveu
CUX1 and CUX2 proteins are characterized by the presence of three highly similar regions called Cut repeats 1, 2, and 3. Although CUX1 is ubiquitously expressed, CUX2 plays an important role in the specification of neuronal cells and continues to be expressed in postmitotic neurons. Cut repeats from the CUX1 protein were recently shown to stimulate 8-oxoguanine DNA glycosylase 1 (OGG1), an enzyme that removes oxidized purines from DNA and introduces a single strand break through its apurinic/apyrimidinic lyase activity to initiate base excision repair...
September 11, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26218442/cross-talk-between-gh-regulated-transcription-factors-hnf6-and-cux2-in-adult-mouse-liver
#18
Tara L Conforto, George F Steinhardt, David J Waxman
Hepatocyte-enriched nuclear factor (HNF)6 and CUX2 are GH and STAT5-regulated homeobox transcription factors. CUX2 shows female-specific expression and contributes to liver sex differences by repressing many male-biased genes and inducing many female-biased genes, whereas HNF6 is expressed at similar levels in male and female liver. In cell-based transfection studies, CUX2 inhibited HNF6 transcriptional regulation of the sex-specific gene promoters CYP2C11 and CYP2C12, blocking HNF6 repression of CYP2C11 and HNF6 activation of CYP2C12...
September 2015: Molecular Endocrinology
https://www.readbyqxmd.com/read/26043187/synthesis-and-reactions-of-3d-metal-complexes-with-the-bulky-alkoxide-ligand-oc-t-bu2ph
#19
James A Bellow, Maryam Yousif, Dong Fang, Eric G Kratz, G Andrés Cisneros, Stanislav Groysman
Treatment of NiCl2(dme) and NiBr2(dme) (dme = dimethoxyethane) with 2 equiv of LiOR (OR = OC(t)Bu2Ph) forms the distorted trigonal planar complexes [NiLiX(OR)2(THF)2] (THF = tetrahydrofuran) 5 (X = Cl) and 6 (X = Br). The reaction of CuX2 (X = Cl, Br) with 2 equiv of LiOR affords the Cu(I) product Cu4(OR)4 (7). The same product can be obtained using the Cu(I) starting material CuCl. NMR studies indicated that the reduction of Cu(II) to Cu(I) is accompanied by the oxidation of the alkoxide RO(-) to form the alkoxy radical RO(•), which subsequently forms tert-butyl phenyl ketone by β-scission...
June 15, 2015: Inorganic Chemistry
https://www.readbyqxmd.com/read/26007699/cux-2-mediated-oxybromination-aminochlorination-of-unsaturated-amides-synthesis-of-iminolactones-and-lactams
#20
Zhi-Qiang Zhang, Feng Liu
We report herein a CuX2-mediated halocyclization of γ,δ-unsaturated amides for the synthesis of functionalized iminolactones and lactams respectively under mild reaction conditions. Mechanism studies indicated that N-attack cyclization was via a radical route while oxycyclization was via a nucleophilic attack on the activated C=C bond.
June 28, 2015: Organic & Biomolecular Chemistry
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