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Prepubertal testicular tumor

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https://www.readbyqxmd.com/read/27799946/anti-m%C3%A3-llerian-hormone-as-a-marker-of-steroid-and-gonadotropin-action-in-the-testis-of-children-and-adolescents-with-disorders-of-the-gonadal-axis
#1
REVIEW
Nadia Y Edelsztein, Romina P Grinspon, Helena F Schteingart, Rodolfo A Rey
In pediatric patients, basal testosterone and gonadotropin levels may be uninformative in the assessment of testicular function. Measurement of serum anti-Müllerian hormone (AMH) has become increasingly widespread since it provides information about the activity of the male gonad without the need for dynamic tests, and also reflects the action of FSH and androgens within the testis. AMH is secreted in high amounts by Sertoli cells from fetal life until the onset of puberty. Basal AMH expression is not dependent on gonadotropins or sex steroids; however, FSH further increases and testosterone inhibits AMH production...
2016: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/27796764/more-cases-of-benign-testicular-teratomas-are-detected-in-adults-than-in-children-a-clinicopathological-study-of-543-testicular-germ-cell-tumor-cases
#2
Semjén David, Farkas András, Kalman Endre, Kaszas Balint, Kovács Árpad, Pusztai Csaba, Szuhai Karoly, Tornóczky Tamás
Benign testicular teratomas are always thought to be pediatric neoplasms and previously all the teratoid tumors in the adult testis regarded as malignant. Recently, three publications reported benign testicular teratomas in adulthood and the latest WHO classification refers them as "prepubertal type of teratomas" which rarely appear in adulthood. These neoplasms behave benign and seemingly analogous independently whether they appear in pre- or postpubertal patients. The aim of our study was to investigate the frequency of benign testicular teratomas both in children and adults...
October 28, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27775285/-testicular-and-paratesticular-tumors-in-prepubertal-children
#3
J Rojas-Ticona, M Fernández-Ibieta, L Nortes Cano, O Girón-Vallejo, P Reyes Ríos, I Martínez Castaño, V Villamil, J I Ruiz Jiménez
OBJECTIVES: To describe our experience in testicular and paratesticular tumors during the prepubertal stage, focusing especially on its character of benignity/malignancy and surgical treatment used. MATERIAL AND METHODS: Retrospective review of all testicular tumors in children under 12 years diagnosed and treated in our clinical setting from 1998-2015. Data on their presentation, study and management were collected. RESULTS: 17 children with prepubertal testicular tumors were identified...
April 15, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27626837/chapter-25-testicular-and-paratesticular-tumors-in-the-pediatric-age-group
#4
Manuel Nistal, Ricardo Paniagua, Pilar Gonzalez-Peramato, Miguel Reyes-Múgica
Testicular tumors in the prepubertal age are relatively rare, representing only 9.4% of the total testicular and paratesticular specimens from a 20 year review performed at a large pediatric hospital 1. They account for 1 to 2 % of all solid tumors in the pediatric age group, with an annual incidence between 0.5 and 2/100,000 boys according to Coppes et al. 2 and data from the Prepubertal Testicular Tumor Registry 3. Similar to other neoplasms afflicting children, a bimodal age distribution is observed. The first peak is between birth and 3 years of age, and a second one occurs at the onset of puberty,extending to the fourth decade...
September 14, 2016: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/27569298/perspectives-on-testicular-germ-cell-neoplasms
#5
Liang Cheng, Bingjian Lyu, Lawrence M Roth
Our knowledge of testicular germ cell neoplasms has progressed in the last few decades due to the description of germ cell neoplasia in situ (GCNIS) and a variety of specific forms of intratubular germ cell neoplasia, the discovery of isochromosome 12p and its importance in the development of invasiveness in germ cell tumors (GCTs), the identification of specific transcription factors for GCTs, and the recognition that a teratomatous component in mixed GCT represents terminal differentiation. Isochromosome 12p and 12p overrepresentation, collectively referred to as 12p amplification, are fundamental abnormalities that account for many types of malignant GCTs of the testis...
August 25, 2016: Human Pathology
https://www.readbyqxmd.com/read/27488929/intratubular-large-cell-hyalinizing-sertoli-cell-tumor-of-the-testis-presenting-with-prepubertal-gynecomastia-a-case-report
#6
Hale Tuhan, Ayhan Abaci, Banu Sarsık, Tülay Öztürk, Mustafa Olguner, Gonul Catli, Ahmet Anik, Nur Olgun, Ece Bober
Intratubular large cell hyalinizing Sertoli cell neoplasia (ITLCHSCN) resulting from Sertoli cells of the testis are mainly reported in young adults and these are rarely seen in childhood. The most common presenting symptoms of the patients diagnosed with ITLCHSCN are gynecomastia, enlargement in the testicles, increase in growth velocity, and advanced bone age. Symptoms are basically resulting from increased aromatase enzyme activity in Sertoli cells. In this case report, an eight-and-a-half-year-old case presenting with complaint of bilateral gynecomastia since two years, showing no endocrine abnormality in laboratory during two years of follow-up, determined to have progression in bilateral gynecomastia, increase in testicular volumes, advanced bone age, increase in growth velocity in the clinical follow-up, and diagnosed with ITLCHSCN after testis biopsy was presented...
August 4, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27152727/risk-of-second-gonadal-cancers-in-women-and-children-with-germ-cell-tumors
#7
Zi Wei Liao, Maria Clarissa Rodrigues, Jenny N Poynter, James F Amatruda, Carlos Rodriguez-Galindo, A Lindsay Frazier
BACKGROUND: Men with testicular cancer have an increased risk of developing cancer in the contralateral testis, but the risks of second gonadal cancers (SGCs) in women and children treated for germ cell tumors (GCTs) have not previously been quantified. METHODS: The incidence of SGCs was ascertained in patients who had survived for at least 1 year after GCT diagnosis using data from the Surveillance, Epidemiology, and End Results SEER 9 registries (1980-2012). Relative risks of SGCs were estimated separately for boys, women, and girls compared with men based on Poisson regression analysis...
July 1, 2016: Cancer
https://www.readbyqxmd.com/read/26987710/prepubertal-testicular-tumors-a-single-center-experience-of-44years
#8
Sayaka Akiyama, Kazuyo Ito, Woo Jin Kim, Yukichi Tanaka, Yuichiro Yamazaki
PURPOSE: To present the clinical and histological features of prepubertal testicular tumors (PTTs), the long-term experience of a single institution was reviewed. MATERIALS AND METHODS: A total of 62 prepubertal children who were treated for testicular tumors at Kanagawa Children's Medical Center from 1971 to 2014 were retrospectively reviewed. Histopathological findings, age at operation, clinical stage, and outcomes were analyzed. Clinical findings between the two eras, 1971-1990 and 1991-2014, were also compared...
August 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26917601/dna-methyltransferase-3-like-protein-expression-in-various-histological-types-of-testicular-germ-cell-tumor
#9
Taeko Matsuoka, Koji Kawai, Satoshi Ando, Shintaro Sugita, Shuya Kandori, Takahiro Kojima, Jun Miyazaki, Hiroyuki Nishiyama
OBJECTIVE: DNA methyltransferase 3-like plays an important role in germ cell development. The aim of this study was to analyse the DNA methyltransferase 3-like protein expression in testicular germ cell tumors. METHODS: The immunohistochemical expression of DNA methyltransferase 3-like was examined in 86 testicular germ cell tumor specimens in various clinical settings. The association between DNA methyltransferase 3-like expression and disease stage was analyzed...
May 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26826410/chromosome-12p-abnormalities-and-imp3-expression-in-prepubertal-pure-testicular-teratomas
#10
Kristine M Cornejo, Liang Cheng, Alanna Church, Mingsheng Wang, Zhong Jiang
Although the histologic appearance of pure testicular teratomas (PTTs) is similar in children and adults, the prognosis is dramatically different. Prepubertal PTTs are rare, with a benign clinical course, whereas the adult cases typically have malignant outcomes. Chromosome 12p abnormalities are seen in most adult testicular germ cell tumors but have not been found in prepubertal PTTs. IMP3 is an oncofetal protein that is highly expressed in many malignancies. Recently, we demonstrated IMP3 is expressed in adult mature testicular teratomas but not in mature ovarian teratomas...
March 2016: Human Pathology
https://www.readbyqxmd.com/read/26777558/immunohistochemical-expression-of-sox9-protein-in%C3%A2-immature-mature-and-neoplastic-canine-sertoli-cells
#11
Barbara Banco, Chiara Palmieri, Giuseppe Sironi, Eleonora Fantinato, Maria C Veronesi, Debora Groppetti, Chiara Giudice, Benedetta Martignoni, Valeria Grieco
Sex-determining region Y box9 gene (SOX9) protein plays a pivotal role in male sexual development. It regulates the transcription of the anti-Müllerian hormone gene promoting development of testis cords, multiplication, and maturation of Sertoli cells (SCs) and maintenance of spermatogenesis in adult testis. The immunohistochemical expression of SOX9 in normal testes has been reported in humans, mice, and rats. The present study aimed to investigate the expression of SOX9 in canine SCs during testicular maturation and neoplastic transformation...
May 2016: Theriogenology
https://www.readbyqxmd.com/read/26717790/-prepubertal-mature-teratoma-of-the-testis-masquerading-of-a-simple-cyst-of-the-testis
#12
REVIEW
Masayuki Nagasawa, Kazuyoshi Johnin, Taichi Sano, Kenichi Kobayashi, Susumu Kageyama, Mitsuhiro Narita, Keisei Okamoto, Akihiro Kawauchi
A 6-month-old boy was referred to our hospital with left scrotal swelling. Scrotal ultrasound examination revealed a 2 cm cystic mass without solid component in left testicular parenchyma. Serum AFP, hCG and LDH levels were within normal limits. Although we suspected a simple cyst of the testis or a benign testicular tumor, the left testicle was explored via an inguinal incision in case of malignancy. Since intraoperative frozen section revealed benign, we preserved the remaining testis. The wall of cystic mass had a small solid lesion...
October 2015: Nihon Hinyōkika Gakkai Zasshi. the Japanese Journal of Urology
https://www.readbyqxmd.com/read/26525589/testicular-leydig-cell-tumor-with-metachronous-lesions-outcomes-after-metastasis-resection-and-cryoablation
#13
Julio J Geminiani, Stephen D Marshall, Tammy S Ho, Steven B Brandes
Leydig cell tumors represent 3% of testicular masses and usually occur in prepubertal boys and men between 30 and 60 years of age. Leydig cell tumors are benign in children but can be malignant in 10% of adults. This case report describes a 41-year-old patient who was diagnosed with a Leydig cell tumor that originated in his right testicle that subsequently metastasized to his liver, lungs, and retroperitoneum. We discuss the patient's presentation and review the radiographic findings, surgical treatment, surgical pathology, chemotherapeutic treatment, and published literature on this rare pathology...
2015: Case Reports in Urology
https://www.readbyqxmd.com/read/26479987/pathologic-risk-factors-in-pediatric-and-adolescent-patients-with-clinical-stage-i-testicular-stromal-tumors
#14
REVIEW
Kyle O Rove, Paul D Maroni, Carrye R Cost, Diane L Fairclough, Gianluca Giannarini, Anne K Harris, Kris A P Schultz, Nicholas G Cost
BACKGROUND: Testicular stromal tumors (TSTs) are rare. In adult men with TSTs, various pathologic risk factors have been identified in patients with clinically localized disease that increase the risk of occult metastatic disease (OMD). We systematically reviewed existing literature to analyze the impact of these risk factors on OMD in prepubertal (0 to 12 y) and postpubertal (13 to 21 y) patients. METHODS: A literature search was conducted using the combination of terms: "testicular stromal tumors," "testicular leydig cell tumors," "testicular sertoli tumors," "testicular interstitial tumors," "testicular granulosa tumor," and "testicular sex cord tumors...
November 2015: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/26366315/a-rare-cause-of-prepubertal-gynecomastia-sertoli-cell-tumor
#15
Fatma Dursun, Şeyma Meliha Su Dur, Ceyhan Şahin, Heves Kırmızıbekmez, Murat Hakan Karabulut, Asım Yörük
Prepubertal gynecomastia due to testis tumors is a very rare condition. Nearly 5% of the patients with testicular mass present with gynecomastia. Sertoli cell tumors are sporadic in 60% of the reported cases, while the remaining is a component of multiple neoplasia syndromes such as Peutz-Jeghers syndrome and Carney complex. We present a 4-year-old boy with gynecomastia due to Sertoli cell tumor with no evidence of Peutz-Jeghers syndrome or Carney complex.
2015: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/26324756/prepubertal-testicular-teratomas-and-epidermoid-cysts-comparison-of-clinical-and-sonographic-features
#16
COMPARATIVE STUDY
Min-Yung Chang, Hyun Joo Shin, Hyun Gi Kim, Myung-Joon Kim, Mi-Jung Lee
OBJECTIVES: To evaluate clinical and sonographic features of testicular teratomas and epidermoid cysts in children and to assess differential points of immature teratomas from benign counterparts. METHODS: We retrospectively reviewed testicular teratomas and epidermoid cysts in children. Age at surgery, α-fetoprotein (AFP) level, and sonographic findings, including components (mainly cystic, mainly solid, or mixed), presence of calcification, and size, were reviewed...
October 2015: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/26137335/embryonal-carcinoma-in-cryptorchid-abdominal-testis-of-an-infant
#17
Atia Zaka-Ur-Rab, Zeeba Zaka-Ur-Rab, Kafil Akhtar
Cryptorchidism is a known predisposing factor for the development of testicular tumors in adults. Age of patient at the time of treatment of undescended testes has some bearing on the risk of neoplasia. Testicular neoplasia at the time of primary surgery for cryptorchidism has been reported rarely in prepubertal period. We report a case where embryonal carcinoma was detected in a cryptorchid testis of an infant.
2015: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/26094168/the-role-of-testis-sparing-surgery-in-children-and-adolescents-with-testicular-tumors
#18
REVIEW
Lynn L Woo, Jonathan H Ross
Organ-sparing approaches have been applied to the treatment of a variety of urologic tumors in both the realms of adult and pediatric urology, with the goals of minimizing overtreatment of benign lesions, preserving function, and providing durable cure. The predominance of benign tumors in prepubertal patients and the reliability of both ultrasound and intraoperative frozen sections have resulted in a marked shift toward testis-sparing approaches over the last few decades. The role of testis sparing in the adolescent population is presently unclear, although there have been increasing reports of successful organ-sparing surgery for testis tumors in the adult literature...
February 2016: Urologic Oncology
https://www.readbyqxmd.com/read/26053334/resolution-of-precocious-puberty-following-resection-of-fourth-ventricular-medulloblastoma-case-report
#19
Renata G Medina, David P Dempsher, Karen M Gauvain, Thomas J Geller, Samer K Elbabaa
Medulloblastoma is a malignant embryonal tumor that arises in the cerebellum and invades the fourth ventricle, often resulting in obstructive hydrocephalus. Patients typically present with symptoms related to increased intracranial pressure and cerebellar dysfunction. The authors report a rare case of classic medulloblastoma with central precocious puberty (CPP) as its only presenting symptom. A 7-year-old boy with no prior history of medulloblastoma presented with Tanner Stage IV testicular enlargement and a 4-month history of acne and pubic hair...
September 2015: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/26032139/histology-of-testicular-biopsies-obtained-for-experimental-fertility-preservation-protocol-in-boys-with-cancer
#20
Eugene J Pietzak, Gregory E Tasian, Sarah K Tasian, Ralph L Brinster, Claire Carlson, Jill P Ginsberg, Thomas F Kolon
PURPOSE: Cryopreservation of testicular tissue with subsequent reimplantation after therapy has the potential to preserve fertility for prepubertal boys with cancer. We present the histology and feasibility of testicular tissue procurement for this novel approach. MATERIALS AND METHODS: We performed a prospective cohort study of boys at significant risk for treatment associated gonadotoxicity who were eligible for an experimental research protocol between 2008 and 2011...
November 2015: Journal of Urology
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