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Prepubertal testicular tumor

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https://www.readbyqxmd.com/read/29102152/testicular-tumors-in-prepubescent-patients
#1
Ilan I Maizlin, Matthew Dellinger, Kenneth W Gow, Adam B Goldin, Melanie Goldfarb, Jed G Nuchtern, Monica Langer, Sanjeev A Vasudevan, John J Doski, Mehul V Raval, Elizabeth A Beierle
BACKGROUND/PURPOSE: Pediatric testicular tumors are rare, constituting only 1% of all pediatric solid tumors. Single-institution studies addressing pediatric testicular tumors published to date have been limited in the number of patients. METHODS: We utilized the National Cancer Data Base (1998-2012) to review all prepubescent patients (≤12 years old) with testicular neoplasms. Demographics, tumor characteristics, treatment modalities, and outcomes were abstracted...
October 8, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28845050/preservation-of-fertility-or-ovarian-function-in-patients-with-breast-cancer-or-gynecologic-and-internal-malignancies
#2
Angrit Stachs, Steffi Hartmann, Bernd Gerber
Because of the efficacy of systemic therapies, neoplasias which occur in pediatric and adolescent patients and in young adults have high cure rates. This means that fulfilling their wish to have children has become a more pressing concern, particularly among young women with malignant tumors. Premature ovarian failure is also a not insignificant problem as it has a lasting detrimental effect on quality of life. Every oncology patient who may potentially wish to have children should be informed about their options for preserving fertility prior to starting treatment...
August 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28474163/-germ-cell-and-sex-cord-stromal-tumors-of-the-testis-who-classification-2016
#3
G Mikuz
Earlier revisions of the WHO classification of testicular tumors, which was originally published in 1977, contained only minor additions. In the WHO 2016 classification, in contrast, germ cell tumors are split into two major groups based on their distinct pathohistogenesis, i. e., those which derive from an in situ forerunner lesion and those which do not. The latter category includes prepubertal yolk sac tumors and teratomas, as well as spermatocytic seminoma. The classification of yolk sac tumors and teratomas as arising before or after puberty is also of prognostic value...
May 2017: Der Pathologe
https://www.readbyqxmd.com/read/28130393/irradiation-affects-germ-and-somatic-cells-in-prepubertal-monkey-testis-xenografts
#4
I Tröndle, B Westernströer, J Wistuba, N Terwort, S Schlatt, N Neuhaus
Study question: Does irradiation evoke adverse effects in germ and somatic cells in testis xenografts from prepubertal monkeys? Summary answer: In addition to the expected depletion of germ cells, a dose-dependent effect of irradiation was observed at the mRNA and protein level in Sertoli and peritubular myoid cells. What is known already: Testicular irradiation studies in monkeys have focused on the dose-dependent effects on germ cells. Previous studies using intact animals or xenografts reported that germ cells are highly sensitive to irradiation...
March 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27940757/atypical-leydig-cell-tumor-in-children-report-of-2-cases
#5
Chiara Mameli, Giorgio Selvaggio, Chiara Cerini, Gaetano Bulfamante, Cristina Madia, Giovanna Riccipetitoni, Gian Vincenzo Zuccotti
Leydig cell tumors (LCTs) are rare cord-stromal tumors that may occur in testis or ovaries and may produce androgens or estrogens. The majority has been found in men between the ages of 20 and 60 years. Adults with androgen-secreting LCTs are usually asymptomatic; feminizing syndromes may result from the production of estradiol or the peripheral aromatization of testosterone. In children, LCTs usually present between 5 and 10 years of age with isosexual precocious pseudopuberty or gynecomastia. We report 2 cases of LCT in prepubertal boys presenting with advanced unilateral pubarche and testicular volume asymmetry...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27799946/anti-m%C3%A3-llerian-hormone-as-a-marker-of-steroid-and-gonadotropin-action-in-the-testis-of-children-and-adolescents-with-disorders-of-the-gonadal-axis
#6
REVIEW
Nadia Y Edelsztein, Romina P Grinspon, Helena F Schteingart, Rodolfo A Rey
In pediatric patients, basal testosterone and gonadotropin levels may be uninformative in the assessment of testicular function. Measurement of serum anti-Müllerian hormone (AMH) has become increasingly widespread since it provides information about the activity of the male gonad without the need for dynamic tests, and also reflects the action of FSH and androgens within the testis. AMH is secreted in high amounts by Sertoli cells from fetal life until the onset of puberty. Basal AMH expression is not dependent on gonadotropins or sex steroids; however, FSH further increases and testosterone inhibits AMH production...
2016: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/27796764/more-cases-of-benign-testicular-teratomas-are-detected-in-adults-than-in-children-a-clinicopathological-study-of-543-testicular-germ-cell-tumor-cases
#7
Semjén David, Farkas András, Kalman Endre, Kaszas Balint, Kovács Árpad, Pusztai Csaba, Szuhai Karoly, Tornóczky Tamás
Benign testicular teratomas are always thought to be pediatric neoplasms and previously all the teratoid tumors in the adult testis regarded as malignant. Recently, three publications reported benign testicular teratomas in adulthood and the latest WHO classification refers them as "prepubertal type of teratomas" which rarely appear in adulthood. These neoplasms behave benign and seemingly analogous independently whether they appear in pre- or postpubertal patients. The aim of our study was to investigate the frequency of benign testicular teratomas both in children and adults...
July 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27775285/-testicular-and-paratesticular-tumors-in-prepubertal-children
#8
J Rojas-Ticona, M Fernández-Ibieta, L Nortes Cano, O Girón-Vallejo, P Reyes Ríos, I Martínez Castaño, V Villamil, J I Ruiz Jiménez
OBJECTIVES: To describe our experience in testicular and paratesticular tumors during the prepubertal stage, focusing especially on its character of benignity/malignancy and surgical treatment used. MATERIAL AND METHODS: Retrospective review of all testicular tumors in children under 12 years diagnosed and treated in our clinical setting from 1998-2015. Data on their presentation, study and management were collected. RESULTS: 17 children with prepubertal testicular tumors were identified...
April 15, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27626837/perspectives-in-pediatric-pathology-chapter-25-testicular-and-paratesticular-tumors-in-the-pediatric-age-group
#9
REVIEW
Manuel Nistal, Ricardo Paniagua, Pilar González-Peramato, Miguel Reyes-Múgica
Testicular tumors in the prepubertal age are relatively rare, representing only 9.4% of the total testicular and paratesticular specimens from a 20-year review performed at a large pediatric hospital [ 1 ]. They account for 1% to 2% of all solid tumors in the pediatric age group, with an annual incidence between 0.5/100 000 and 2/100 000 boys according to Coppes et al [ 2 ] and data from the Prepubertal Testicular Tumor Registry [ 3 ]. Similar to other neoplasms afflicting children, a bimodal age distribution is observed...
November 2016: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/27569298/perspectives-on-testicular-germ-cell-neoplasms
#10
Liang Cheng, Bingjian Lyu, Lawrence M Roth
Our knowledge of testicular germ cell neoplasms has progressed in the last few decades due to the description of germ cell neoplasia in situ (GCNIS) and a variety of specific forms of intratubular germ cell neoplasia, the discovery of isochromosome 12p and its importance in the development of invasiveness in germ cell tumors (GCTs), the identification of specific transcription factors for GCTs, and the recognition that a teratomatous component in mixed GCT represents terminal differentiation. Isochromosome 12p and 12p overrepresentation, collectively referred to as 12p amplification, are fundamental abnormalities that account for many types of malignant GCTs of the testis...
January 2017: Human Pathology
https://www.readbyqxmd.com/read/27488929/intratubular-large-cell-hyalinizing-sertoli-cell-tumor-of-the-testis-presenting-with-prepubertal-gynecomastia-a-case-report
#11
Hale Tuhan, Ayhan Abaci, Banu Sarsık, Tülay Öztürk, Mustafa Olguner, Gonul Catli, Ahmet Anik, Nur Olgun, Ece Bober
Intratubular large cell hyalinizing Sertoli cell neoplasia (ITLCHSCN) resulting from Sertoli cells of the testis are mainly reported in young adults and these are rarely seen in childhood. The most common presenting symptoms of the patients diagnosed with ITLCHSCN are gynecomastia, enlargement in the testicles, increase in growth velocity, and advanced bone age. Symptoms are basically resulting from increased aromatase enzyme activity in Sertoli cells. In this case report, an eight-and-a-half-year-old case presenting with complaint of bilateral gynecomastia since two years, showing no endocrine abnormality in laboratory during two years of follow-up, determined to have progression in bilateral gynecomastia, increase in testicular volumes, advanced bone age, increase in growth velocity in the clinical follow-up, and diagnosed with ITLCHSCN after testis biopsy was presented...
August 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27152727/risk-of-second-gonadal-cancers-in-women-and-children-with-germ-cell-tumors
#12
Zi Wei Liao, Maria Clarissa Rodrigues, Jenny N Poynter, James F Amatruda, Carlos Rodriguez-Galindo, A Lindsay Frazier
BACKGROUND: Men with testicular cancer have an increased risk of developing cancer in the contralateral testis, but the risks of second gonadal cancers (SGCs) in women and children treated for germ cell tumors (GCTs) have not previously been quantified. METHODS: The incidence of SGCs was ascertained in patients who had survived for at least 1 year after GCT diagnosis using data from the Surveillance, Epidemiology, and End Results SEER 9 registries (1980-2012). Relative risks of SGCs were estimated separately for boys, women, and girls compared with men based on Poisson regression analysis...
July 1, 2016: Cancer
https://www.readbyqxmd.com/read/26987710/prepubertal-testicular-tumors-a-single-center-experience-of-44years
#13
Sayaka Akiyama, Kazuyo Ito, Woo Jin Kim, Yukichi Tanaka, Yuichiro Yamazaki
PURPOSE: To present the clinical and histological features of prepubertal testicular tumors (PTTs), the long-term experience of a single institution was reviewed. MATERIALS AND METHODS: A total of 62 prepubertal children who were treated for testicular tumors at Kanagawa Children's Medical Center from 1971 to 2014 were retrospectively reviewed. Histopathological findings, age at operation, clinical stage, and outcomes were analyzed. Clinical findings between the two eras, 1971-1990 and 1991-2014, were also compared...
August 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26917601/dna-methyltransferase-3-like-protein-expression-in-various-histological-types-of-testicular-germ-cell-tumor
#14
Taeko Matsuoka, Koji Kawai, Satoshi Ando, Shintaro Sugita, Shuya Kandori, Takahiro Kojima, Jun Miyazaki, Hiroyuki Nishiyama
OBJECTIVE: DNA methyltransferase 3-like plays an important role in germ cell development. The aim of this study was to analyse the DNA methyltransferase 3-like protein expression in testicular germ cell tumors. METHODS: The immunohistochemical expression of DNA methyltransferase 3-like was examined in 86 testicular germ cell tumor specimens in various clinical settings. The association between DNA methyltransferase 3-like expression and disease stage was analyzed...
May 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26826410/chromosome-12p-abnormalities-and-imp3-expression-in-prepubertal-pure-testicular-teratomas
#15
MULTICENTER STUDY
Kristine M Cornejo, Liang Cheng, Alanna Church, Mingsheng Wang, Zhong Jiang
Although the histologic appearance of pure testicular teratomas (PTTs) is similar in children and adults, the prognosis is dramatically different. Prepubertal PTTs are rare, with a benign clinical course, whereas the adult cases typically have malignant outcomes. Chromosome 12p abnormalities are seen in most adult testicular germ cell tumors but have not been found in prepubertal PTTs. IMP3 is an oncofetal protein that is highly expressed in many malignancies. Recently, we demonstrated IMP3 is expressed in adult mature testicular teratomas but not in mature ovarian teratomas...
March 2016: Human Pathology
https://www.readbyqxmd.com/read/26777558/immunohistochemical-expression-of-sox9-protein-in%C3%A2-immature-mature-and-neoplastic-canine-sertoli-cells
#16
Barbara Banco, Chiara Palmieri, Giuseppe Sironi, Eleonora Fantinato, Maria C Veronesi, Debora Groppetti, Chiara Giudice, Benedetta Martignoni, Valeria Grieco
Sex-determining region Y box9 gene (SOX9) protein plays a pivotal role in male sexual development. It regulates the transcription of the anti-Müllerian hormone gene promoting development of testis cords, multiplication, and maturation of Sertoli cells (SCs) and maintenance of spermatogenesis in adult testis. The immunohistochemical expression of SOX9 in normal testes has been reported in humans, mice, and rats. The present study aimed to investigate the expression of SOX9 in canine SCs during testicular maturation and neoplastic transformation...
May 2016: Theriogenology
https://www.readbyqxmd.com/read/26717790/-prepubertal-mature-teratoma-of-the-testis-masquerading-of-a-simple-cyst-of-the-testis
#17
REVIEW
Masayuki Nagasawa, Kazuyoshi Johnin, Taichi Sano, Kenichi Kobayashi, Susumu Kageyama, Mitsuhiro Narita, Keisei Okamoto, Akihiro Kawauchi
A 6-month-old boy was referred to our hospital with left scrotal swelling. Scrotal ultrasound examination revealed a 2 cm cystic mass without solid component in left testicular parenchyma. Serum AFP, hCG and LDH levels were within normal limits. Although we suspected a simple cyst of the testis or a benign testicular tumor, the left testicle was explored via an inguinal incision in case of malignancy. Since intraoperative frozen section revealed benign, we preserved the remaining testis. The wall of cystic mass had a small solid lesion...
October 2015: Nihon Hinyōkika Gakkai Zasshi. the Japanese Journal of Urology
https://www.readbyqxmd.com/read/26525589/testicular-leydig-cell-tumor-with-metachronous-lesions-outcomes-after-metastasis-resection-and-cryoablation
#18
Julio J Geminiani, Stephen D Marshall, Tammy S Ho, Steven B Brandes
Leydig cell tumors represent 3% of testicular masses and usually occur in prepubertal boys and men between 30 and 60 years of age. Leydig cell tumors are benign in children but can be malignant in 10% of adults. This case report describes a 41-year-old patient who was diagnosed with a Leydig cell tumor that originated in his right testicle that subsequently metastasized to his liver, lungs, and retroperitoneum. We discuss the patient's presentation and review the radiographic findings, surgical treatment, surgical pathology, chemotherapeutic treatment, and published literature on this rare pathology...
2015: Case Reports in Urology
https://www.readbyqxmd.com/read/26479987/pathologic-risk-factors-in-pediatric-and-adolescent-patients-with-clinical-stage-i-testicular-stromal-tumors
#19
REVIEW
Kyle O Rove, Paul D Maroni, Carrye R Cost, Diane L Fairclough, Gianluca Giannarini, Anne K Harris, Kris A P Schultz, Nicholas G Cost
BACKGROUND: Testicular stromal tumors (TSTs) are rare. In adult men with TSTs, various pathologic risk factors have been identified in patients with clinically localized disease that increase the risk of occult metastatic disease (OMD). We systematically reviewed existing literature to analyze the impact of these risk factors on OMD in prepubertal (0 to 12 y) and postpubertal (13 to 21 y) patients. METHODS: A literature search was conducted using the combination of terms: "testicular stromal tumors," "testicular leydig cell tumors," "testicular sertoli tumors," "testicular interstitial tumors," "testicular granulosa tumor," and "testicular sex cord tumors...
November 2015: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/26366315/a-rare-cause-of-prepubertal-gynecomastia-sertoli-cell-tumor
#20
Fatma Dursun, Şeyma Meliha Su Dur, Ceyhan Şahin, Heves Kırmızıbekmez, Murat Hakan Karabulut, Asım Yörük
Prepubertal gynecomastia due to testis tumors is a very rare condition. Nearly 5% of the patients with testicular mass present with gynecomastia. Sertoli cell tumors are sporadic in 60% of the reported cases, while the remaining is a component of multiple neoplasia syndromes such as Peutz-Jeghers syndrome and Carney complex. We present a 4-year-old boy with gynecomastia due to Sertoli cell tumor with no evidence of Peutz-Jeghers syndrome or Carney complex.
2015: Case Reports in Pediatrics
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