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https://www.readbyqxmd.com/read/28532031/screening-of-process-variables-to-enhance-the-solubility-of-famotidine-with-2-hydroxypropyl-%C3%AE-cyclodextrin-pvp-k-30-by-using-plackett-burman-design-approach
#1
Umakant Verma, Jitendra B Naik, Jayesh S Patil, Sunil K Yadava
In the present work, inclusion complex of famotidine (FMT) was prepared with (2-HydroxyPropyl)-β-Cyclodextrin (HP-β-CyD) and polyvinylpyrrolidone K-30 (PVP K-30) by spray drying technique to enhance the solubility of famotidine. FMT is a potent histamine H2-receptor antagonist having low solubility as well as oral bioavailability. In order to enhance the solubility of FMT, a quality by design (QbD) approach has been used by employing Plackett-Burman design (PBD). With the application of PBD, seven independent process variables were investigated and optimized for maximum solubility...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532024/the-effect-of-pore-size-and-porosity-on-mechanical-properties-and-biological-response-of-porous-titanium-scaffolds
#2
C Torres-Sanchez, F R A Al Mushref, M Norrito, K Yendall, Y Liu, P P Conway
The effect of pore size and porosity on elastic modulus, strength, cell attachment and cell proliferation was studied for Ti porous scaffolds manufactured via powder metallurgy and sintering. Porous scaffolds were prepared in two ranges of porosities so that their mechanical properties could mimic those of cortical and trabecular bone respectively. Space-holder engineered pore size distributions were carefully determined to study the impact that small changes in pore size may have on mechanical and biological behaviour...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531987/electrospinning-of-thermoplastic-carboxymethyl-cellulose-poly-ethylene-oxide-nanofibers-for-use-in-drug-release-systems
#3
Akbar Esmaeili, Mahsa Haseli
Polymeric delivery systems using electrospun nanofibers have been developed for many applications, notably for drug delivery and tissue engineering in the healthcare industry. In this study, a nanofiber drug carrier was fabricated via two different electrospinning processes, blend and coaxial, using a new degradable thermoplastic carboxymethyl cellulose (TCMC) and poly(ethylene oxide) (PEO). The TCMC was synthesized by graft copolymerization with methyl acrylate. Tetracycline hydrochloride served as a drug model incorporated within these nanofibers and their performance as a drug-carrier scaffold was evaluated...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531978/quasi-static-and-ratcheting-properties-of-trabecular-bone-under-uniaxial-and-cyclic-compression
#4
Li-Lan Gao, Chao-Lei Wei, Chun-Qiu Zhang, Hong Gao, Nan Yang, Li-Min Dong
The quasi-static and ratcheting properties of trabecular bone were investigated by experiments and theoretical predictions. The creep tests with different stress levels were completed and it is found that both the creep strain and creep compliance increase rapidly at first and then increase slowly as the creep time goes by. With increase of compressive stress the creep strain increases and the creep compliance decreases. The uniaxial compressive tests show that the applied stress rate makes remarkable influence on the compressive behaviors of trabecular bone...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531969/biogeographical-factors-affecting-the-distribution-of-stream-salamanders-on-the-cumberland-plateau-usa
#5
P R Gould, K K Cecala, S S Drukker, B A McKenzie, C Van de Ven
Geophysical and climate conditions play an important role in the distribution of organisms at both fine and broad scales. Headwater streams integrate changes at broad geographical scales and serve as important regions of nutrient processing and support high biodiversity. Stream salamanders are important members of headwater aquatic communities as both predators and prey. Combined with their biphasic life histories and physiological requirements, stream amphibians may serve as indicators for headwater stream conditions...
May 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531966/how-do-disturbances-and-climate-effects-on-carbon-and-water-fluxes-differ-between-multi-aged-and-even-aged-coniferous-forests
#6
Xuguang Tang, Hengpeng Li, Mingguo Ma, Li Yao, Matthias Peichl, Altaf Arain, Xibao Xu, Michael Goulden
Disturbances and climatic changes significantly affect forest ecosystem productivity, water use efficiency (WUE) and carbon (C) flux dynamics. A deep understanding of terrestrial feedbacks to such effects and recovery mechanisms in forests across contrasting climatic regimes is essential to predict future regional/global C and water budgets, which are also closely related to the potential forest management decisions. However, the resilience of multi-aged and even-aged forests to disturbances has been debated for >60years because of technical measurement constraints...
May 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531962/how-geostatistics-can-help-you-find-lead-and-galvanized-water-service-lines-the-case-of-flint-mi
#7
Pierre Goovaerts
In the aftermath of Flint drinking water crisis, most US cities have been scrambling to locate all lead service lines (LSLs) in their water supply systems. This information, which is most often inaccurate or lacking, is critical to assess compliance with the Lead and Copper Rule and to plan the replacement of lead and galvanized service lines (GSLs) as currently under way in Flint. This paper presents the first geospatial approach to predict the likelihood that a home has a LSL or GSL based on neighboring field data (i...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531949/wastewater-discharge-impact-on-drinking-water-sources-along-the-yangtze-river-china
#8
Zhuomin Wang, Dongguo Shao, Paul Westerhoff
Unplanned indirect (de facto) wastewater reuse occurs when wastewater is discharged into surface waters upstream of potable drinking water treatment plant intakes. This paper aims to predict percentages and trends of de facto reuse throughout the Yangtze River watershed in order to understand the relative contribution of wastewater discharges into the river and its tributaries towards averting water scarcity concerns. The Yangtze River is the third longest in the world and supports more than 1/15 of the world's population, yet the importance of wastewater on the river remains ill-defined...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531902/evaluation-of-prostate-imaging-reporting-and-data-system-classification-in-the-prediction-of-tumor-aggressiveness-in-targeted-magnetic-resonance-imaging-ultrasound-fusion-biopsy
#9
Angelika Borkowetz, Ivan Platzek, Marieta Toma, Theresa Renner, Roman Herout, Martin Baunacke, Michael Laniado, Gustavo B Baretton, Michael Froehner, Stefan Zastrow, Manfred P Wirth
OBJECTIVES: The study aimed to evaluate the prediction of Prostate Imaging Reporting and Data System (PI-RADS) with respect to the prostate cancer (PCa) detection rate and tumor aggressiveness in magnetic resonance imaging (MRI)/ultrasound-fusion-biopsy (fusPbx) and in systematic biopsy (sysPbx). MATERIALS AND METHODS: Six hundred and twenty five patients undergoing multiparametric MRI were investigated. MRI findings were classified using PI-RADS v1 or v2. All patients underwent fusPbx combined with sysPbx (comPbx)...
May 23, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28531895/arterial-stiffness-is-an-independent-risk-factor-for-anemia-after-percutaneous-native-kidney-biopsy
#10
Keiko Tanaka, Masashi Kitagawa, Akifumi Onishi, Toshio Yamanari, Ayu Ogawa-Akiyama, Koki Mise, Tatsuyuki Inoue, Hiroshi Morinaga, Haruhito A Uchida, Hitoshi Sugiyama, Jun Wada
BACKGROUND/AIMS: Bleeding is the most common complication after renal biopsy. Although numerous predictors of bleeding have been reported, it remains unclear whether arterial stiffness affects bleeding complications. METHOD: We performed an observational study of the renal biopsies performed in our division over an approximately 6-year period (May 2010 to May 2016). The clinical and laboratory factors were analyzed to reveal the risk factors associated with bleeding, with a focus on anemia (defined as a ≥10% decrease in hemoglobin [Hb] after biopsy)...
May 25, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28531894/evaluation-of-absolute-serum-creatinine-changes-in-staging-of-cirrhosis-induced-acute-renal-injury-and-its-association-with-long-term-outcomes
#11
Fangfang Zhou, Qun Luo, Lina Han, Huadong Yan, Wenhong Zhou, Zemin Wang, Yumei Li
BACKGROUND/AIMS: To assess the prognostic accuracy of absolute serum creatinine (sCr) changes ('Delta-sCr') on the long-term outcomes in cirrhotic patients, and evaluate the performance of the 'Delta-sCr' approach to stage acute kidney injury (AKI), compared with the Kidney Disease Improving Global Outcomes (KDIGO) criteria. METHODS: We conducted a retrospective analysis of 333 hospitalized patients. We classified AKI stages using two methods: 1) KDIGO AKI criteria; 2) 'Delta-sCr' system, defined by the difference between the baseline and the peak sCr value during the hospitalization...
May 25, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28531893/association-study-of-serotonin-3-receptor-subunit-gene-variants-in-antipsychotic-induced-weight-gain
#12
Clement C Zai, Arun K Tiwari, Nabilah I Chowdhury, Eva J Brandl, Sajid A Shaikh, Natalie Freeman, Jeffrey A Lieberman, Herbert Y Meltzer, James L Kennedy, Daniel J Müller
BACKGROUND: Schizophrenia (SCZ) is a chronic severe neuropsychiatric disorder, where pharmacological treatment has been hindered by adverse effects, including antipsychotic-induced weight gain (AIWG) and related complications. Genetic studies have been exploring the appetite regulation and energy homeostasis pathways in AIWG with some promising leads. The serotonin system has been shown to participate in these pathways. METHODS: In the current study, we examined single nucleotide polymorphisms across the serotonin receptor genes HTR3A and HTR3B...
May 23, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28531884/pre-interventional-kynurenine-predicts-medium-term-outcome-after-contrast-media-exposure-due-to-coronary-angiography
#13
Christoph Reichetzeder, Fabian Heunisch, Gina von Einem, Oleg Tsuprykov, Karl-Heinz Kellner, Thomas Dschietzig, Axel Kretschmer, Berthold Hocher
BACKGROUND/AIMS: Contrast induced acute kidney injury (CI-AKI) remains a serious complication of contrast media enhanced procedures like coronary angiography. There is still a lack of established biomarkers that help to identify patients at high risk for short and long-term complications. The aim of the current study was to evaluate plasma kynurenine as a predictive biomarker for CI-AKI and long-term complications, measured by the combined endpoint "major adverse kidney events" (MAKE) up to 120 days after CM application...
May 25, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28531868/a-case-of-traumatic-cardiopulmonary-arrest-with-good-neurological-outcome-predicted-by-amplitude-integrated-electroencephalogram
#14
Ko Harada, Kohei Tsukahara, Tetsuya Yumoto, Yasuaki Yamakawa, Atsuyoshi Iida, Hiromichi Naito, Atsunori Nakao
INTRODUCTION: Traumatic cardiopulmonary arrest has a very high mortality, and survival of patients with this condition without neurological disability is rare. PRESENTATION OF CASE: We herein report a case of traumatic cardiopulmonary arrest secondary to accidental amputation of the left lower leg that was successfully treated without any higher brain dysfunction. Although the long duration of cardiopulmonary arrest in this patient suggested hypoxic ischemic encephalopathy, amplitude-integrated electroencephalogram showed normal findings...
May 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28531864/determination-of-volumetric-gas-liquid-mass-transfer-coefficient-of-carbon-monoxide-in-a-batch-cultivation-system-using-kinetic-simulations
#15
Nulee Jang, Muhammad Yasin, Shinyoung Park, Robert W Lovitt, In Seop Chang
A mathematical model of microbial kinetics was introduced to predict the overall volumetric gas-liquid mass transfer coefficient (kLa) of carbon monoxide (CO) in a batch cultivation system. The cell concentration (X), acetate concentration (Cace), headspace gas (Nco and [Formula: see text] ), dissolved CO concentration in the fermentation medium (Cco), and mass transfer rate (R) were simulated using a variety of kLa values. The simulated results showed excellent agreement with the experimental data for a kLa of 13/hr...
May 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28531861/greenhouse-gases-from-membrane-bioreactors-mathematical-modelling-sensitivity-and-uncertainty-analysis
#16
Giorgio Mannina, Alida Cosenza, George A Ekama
In this study a new mathematical model to quantify greenhouse gas emissions (namely, carbon dioxide and nitrous oxide) from membrane bioreactors (MBRs) is presented. The model has been adopted to predict the key processes of a pilot plant with pre-denitrification MBR scheme, filled with domestic and saline wastewater. The model was calibrated by adopting an advanced protocol based on an extensive dataset. In terms of nitrous oxide, the results show that an important role is played by the half saturation coefficients related to nitrogen removal processes and the model factors affecting the oxygen transfer rate in the aerobic and MBR tanks...
May 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28531841/positive-affective-functioning-in-anhedonic-individuals-daily-life-anything-but-flat-and-blunted
#17
V E Heininga, E Van Roekel, J J Ahles, A J Oldehinkel, A H Mezulis
BACKGROUND: Anhedonia, the decreased interest and pleasure, is often described as 'flat' or 'blunted' positive affect (PA). Yet, little is known about PA functioning in anhedonic individuals' daily lives. The current study investigates PA reactivity to pleasurable experiences in anhedonia together with its relevant temporal dynamics (i.e., variability, instability, and inertia), and expands current knowledge by exploring the role of arousal therein. METHODS: Using the Experience Sampling Method (ESM), we collected 90 assessments of real-life PA experiences across 30 days in 18-24 year old individuals with anhedonia (N=69) and without anhedonia (N=69)...
April 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28531818/pharmacophore-searching-a-potential-solution-for-correcting-unknown-ligands-unk-labelling-errors-in-protein-data-bank-pdb-s
#18
Musadiq Ibrahim, Adrian Jonathan Lapthorn, Mohammad Ibrahim
The Protein Data Bank (PDB) is the single most important repository of structural data for proteins and other biologically relevant molecules. Therefore, it is critically important to keep the PDB data, error-free as much as possible. In this study, we have critically examined PDB structures of 292 protein molecules which have been deposited in the repository along with potentially incorrect ligands labelled as Unknown ligands (UNK). Pharmacophores were generated for all the protein structures by using Discovery Studio Visualizer (DSV) and Accelrys, Catalyst(®)...
April 4, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28531816/predicted-phototoxicities-of-carbon-nano-material-by-quantum-mechanical-calculations
#19
Don Betowski
The purpose of this research was to develop a predictive model for the phototoxicity potential of carbon nanomaterials (fullerenols and single-walled carbon nanotubes). This model is based on the quantum mechanical (ab initio) calculations on these carbon-based materials and comparison of the triplet excited states of these materials to published work relating phototoxicity of polynuclear aromatic hydrocarbons (PAH) to their predictive triplet excited state energy. A successful outcome will add another tool to the arsenal of predictive methods for the U...
March 31, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28531809/multifocal-visual-evoked-potentials-in-optic-neuritis-and-multiple-sclerosis-a-review
#20
REVIEW
Gorm Pihl-Jensen, Mathias Falck Schmidt, Jette Lautrup Frederiksen
Multifocal visual evoked potential (mf-VEP) represents a new approach to the classical full field (ff-)VEP with separate responses from up to 60 sectors of the visual field. A thorough literature survey of the use of mf-VEP in optic neuritis (ON) and multiple sclerosis (MS) is presented (38 published studies were retrieved). Mf-VEP provides direct topographical information of specific lesions and facilitates investigations on structural-functional correlations thus providing new methods for exploring the interplay between demyelination, atrophy and remyelination in MS...
April 11, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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