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Rheumatic heart disease children risk factor

Kathryn V Roberts, Graeme P Maguire, Alex Brown, David N Atkinson, Bo Remenyi, Gavin Wheaton, Marcus Ilton, Jonathan Carapetis
OBJECTIVES: To compare regional differences in the prevalence of rheumatic heart disease (RHD) detected by echocardiographic screening in high-risk Indigenous Australian children, and to describe the logistical and other practical challenges of RHD screening. DESIGN: Cross-sectional screening survey performed between September 2008 and November 2010. SETTING: Thirty-two remote communities in four regions of northern and central Australia. PARTICIPANTS: 3946 Aboriginal or Torres Strait Islander children aged 5-15 years...
September 7, 2015: Medical Journal of Australia
Andreas Petropoulos, Doris Ehringer-Schetitska, Peter Fritsch, Eero Jokinen, Robert Dalla Pozza, Renate Oberhoffer
OBJECTIVE: The burden of cardiac disease in childhood is unknown. It will be a sum of 1% of living births in the general population, suffering from Congenital Heart Disease (CHD) + approximately 2.5% of the general population suffering from bicuspid aortic valve diseases + an unknown higher prevalence of acquired diseases. Cardiomyopathies, arrhythmias - sudden cardiac death (SCD), rheumatic heard disease, hypertension and accelerating atherosclerosis are among the most frequent. Adding on, genetic syndromes including cardiac defects, endocarditis and myocarditis we can address a large pediatric population worldwide, suffering from heart disease...
September 2015: Hellenic Journal of Nuclear Medicine
Sherif M Yousry, Yasser Sedky, Alaa Sobieh
UNLABELLED: Aim Rheumatic heart disease is an inflammatory disease of cardiac tissue. The underlying pathogenic mechanisms highlight a complex interplay of immunological, genetic, and environmental factors. The aim of the present study was to investigate whether IL-4 (intron 3) and IL-10 (-1082) gene polymorphisms could be associated with susceptibility and/or severity of rheumatic heart disease among patients from the Egyptian population. Materials and methods A cohort of 140 Egyptian children with rheumatic heart disease and 100 healthy controls were enrolled in this case-control study...
October 2016: Cardiology in the Young
Brigette Gleason, Grace Mirembe, Judith Namuyonga, Emmy Okello, Peter Lwabi, Irene Lubega, Sulaiman Lubega, Victor Musiime, Cissy Kityo, Robert A Salata, Chris T Longenecker
Rheumatic heart disease (RHD) remains highly prevalent in resource-constrained settings around the world, including countries with high rates of HIV/AIDS. Although both are immune-mediated diseases, it is unknown whether HIV modifies the risk or progression of RHD. We performed screening echocardiography to determine the prevalence of latent RHD in 488 HIV-infected children aged 5-18 in Kampala, Uganda. The overall prevalence of borderline/definite RHD was 0.82% (95% confidence interval: 0.26% to 2.23%), which is lower than the published prevalence rates of 1...
February 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Tamirat Moges, Etsegenet Gedlu, Petros Isaakidis, Ajay Kumar, Rafael Van Den Berge, Mohammed Khogali, Amha Mekasha, Sven Gudmund Hinderaker
INTRODUCTION: Infective endocarditis is an infection of the endocardial lining of the heart mainly associated with congenital and rheumatic heart disease. Although it is a rare disease in children, it is associated with high morbidity and mortality; death due to infective endocarditis has been reported to be as high as 26% in sub-Saharan Africa. METHODS: This was a retrospective review of routinely collected data from patient records. RESULTS: A total of 40 children (71% female) with 41 episodes of infective endocarditis admitted to a general paediatric ward in Addis Ababa, Ethiopia between 2008 and 2013...
2015: Pan African Medical Journal
Helen S Marshall, Peter Richmond, Michael Nissen, Stephen Lambert, Robert Booy, Graham Reynolds, Shite Sebastian, Michael Pride, Kathrin U Jansen, Annaliesa S Anderson, Ingrid L Scully
BACKGROUND: Group A streptococci (GAS) and other β-hemolytic streptococci (BHS) cause pharyngitis, severe invasive disease and serious nonsuppurative sequelae including rheumatic heart disease and post streptococcal glomerulonephritis. The aim of this study was to assess carriage rates and anti-streptococcal C5a peptidase (anti-SCP) IgG levels and identify epidemiologic factors related to carriage or seropositivity in Australian children. METHODS: A throat swab and blood sample were collected for microbiological and serological analysis (anti-SCP IgG) in 542 healthy children aged 0-10 years...
August 2015: Pediatric Infectious Disease Journal
Rachel H Webb, Tom L Gentles, John W Stirling, Mildred Lee, Clare O'Donnell, Nigel J Wilson
BACKGROUND: There is increasing use of portable echocardiography as a screening test for rheumatic heart disease (RHD). The prevalence of valvular regurgitation in healthy populations as determined using portable echocardiography has not been well defined. Minimal echocardiographic criteria for RHD have recently been clarified, but the overlap of normal and abnormal valvular regurgitation warrants further study. The aim of this study was to determine the spectrum of echocardiographic findings using portable echocardiography in children from a population with low prevalence of RHD...
August 2015: Journal of the American Society of Echocardiography
Sophie Mavrogeni, George Servos, Roubini Smerla, George Markousis-Mavrogenis, Georgia Grigoriadou, Genovefa Kolovou, George Papadopoulos
Cardiac involvement in pediatric systemic autoimmune diseases has a wide spectrum of presentation ranging from asymptomatic to severe clinically overt involvement. Coronary artery disease, pericardial, myocardial, valvular and rythm disturbances are the most common causes of heart lesion in pediatric systemic autoimmune diseases and cannot be explained only by the traditional cardiovascular risk factors. Therefore, chronic inflammation has been considered as an additive causative factor of cardiac disease in these patients...
2015: Inflammation & Allergy Drug Targets
Lucia Romani, Josefa Koroivueta, Andrew C Steer, Mike Kama, John M Kaldor, Handan Wand, Mohammed Hamid, Margot J Whitfeld
BACKGROUND: Scabies is recognised as a major public health problem in many countries, and is responsible for significant morbidity due to secondary bacterial infection of the skin causing impetigo, abscesses and cellulitis, that can in turn lead to serious systemic complications such as septicaemia, kidney disease and, potentially, rheumatic heart disease. Despite the apparent burden of disease in many countries, there have been few large-scale surveys of scabies prevalence or risk factors...
March 2015: PLoS Neglected Tropical Diseases
Assaf Ben Shoham, Ziona Haklai, Michael Dor, Maskit Bar-Meir
BACKGROUND: Rheumatic Fever (RF) and Kawasaki Disease (KD) are the two leading causes of childhood acquired heart disease in developed countries. AIM: The objective of this paper is to characterize the epidemiologic changes and estimate the incidence rate of RF and KD among children in Israel in the past two decades. METHODS: Using the Israel National Hospital Discharges Register (NHDR), we investigated the epidemiologic features of RF and KD among children in Israel under 18 years of age, between the years 1996 and 2012...
December 2014: Harefuah
C Angkurawaranon, W Jiraporncharoen, B Chenthanakij, P Doyle, D Nitsch
OBJECTIVE: Non-communicable diseases (NCDs) have been highlighted as a major public health issue in the Southeast (SE) Asian region. One of the major socio-environmental factors that are considered to be associated with such a rise in NCDs is urbanization. Urbanization is associated with behavioural changes such as eating an unhealthy diet, and a decrease in physical activities, which may result in associated obesity. The SE Asian region also has a substantive burden of infectious disease such as HIV and malaria, which may modify associations between urbanization and development of NCDs...
October 2014: Public Health
Andrea Beaton, Emmy Okello, Twalib Aliku, Sulaiman Lubega, Peter Lwabi, Charles Mondo, Robert McCarter, Craig Sable
Screening with portable echocardiography has uncovered a large burden of latent rheumatic heart disease (RHD) among asymptomatic children in endemic regions, the significance of which remains unclear. This study aimed to determine the 2-year outcomes for children with latent RHD diagnosed by echocardiographic screening. Children identified with latent RHD enrolled in a biannual follow-up program. Risk factors for disease persistence and progression were examined. Of 62 children, 51 (82 %) with latent RHD had a median follow-up period of 25 months...
October 2014: Pediatric Cardiology
Kathryn Roberts, Graeme Maguire, Alex Brown, David Atkinson, Bo Reményi, Gavin Wheaton, Andrew Kelly, Raman K Kumar, Jiunn-Yih Su, Jonathan R Carapetis
BACKGROUND: Echocardiographic screening for rheumatic heart disease (RHD) is becoming more widespread, but screening studies to date have used different echocardiographic definitions. The World Heart Federation has recently published new criteria for the echocardiographic diagnosis of RHD. We aimed to establish the prevalence of RHD in high-risk Indigenous Australian children using these criteria and to compare the findings with a group of Australian children at low risk for RHD. METHODS AND RESULTS: Portable echocardiography was performed on high-risk Indigenous children aged 5 to 15 years living in remote communities of northern Australia...
May 13, 2014: Circulation
Arkalgud Sampath Kumar
In children with rheumatic heart disease, conservative valve surgery is the best option whenever feasible. Surgeons must develop an attitude and interest in valve repair techniques that can be easily learned. Patients who undergo valve repair at an early age are at risk of requiring additional surgery over time. Mechanical valve replacement, nonetheless, should be reserved for situations where more conservative approaches are not feasible.
January 1, 2014: World Journal for Pediatric & Congenital Heart Surgery
Rachel Webb, Lesley Voss, Sally Roberts, Tim Hornung, Elizabeth Rumball, Diana Lennon
BACKGROUND: New Zealand is a developed country with high incidence of bacterial infections and postinfectious sequelae including rheumatic heart disease. We sought to describe the clinical and microbiology features of children with infective endocarditis (IE) between 1994 and 2012. METHODS: Retrospective review of patients <16 years identified from hospital records. RESULTS: In total 85 episodes occurred in 82 children and 68 (80%) were classified as Definite IE and 17 as Possible IE according to modified Duke criteria...
May 2014: Pediatric Infectious Disease Journal
Julius A Ogeng'o, Patrick M Gatonga, Beda O Olabu, Diana K Nyamweya, Dennis Ong'era
BACKGROUND: Heart failure in children is a common cause of morbidity and mortality, with high socio-economic burden. Its pattern varies between countries but reports from Africa are few. The data are important to inform management and prevention strategies. OBJECTIVE: To describe the pattern of congestive heart failure in a Kenyan paediatric population. METHODS: This was a retrospective study done at Kenyatta National Hospital, Nairobi Kenya...
May 2013: Cardiovascular Journal of Africa
Pierre-Laurent Massoure, Nicolas-Charles Roche, Gatien Lamblin, Celine Dehan, Eric Kaiser, Laurent Fourcade
INTRODUCTION: Few data are available about pediatric cardiovascular disease (CVD) in the Horn of Africa. The objective of this study was to describe the spectrum of CVD in children in Djibouti. METHODS: Clinical features and management of Djiboutian children between 1 month-old and 15 year-old with CVD were prospectively recorded over a two-year period in Bouffard Military Hospital in Djibouti (January 2009- December 2010). RESULTS: Clinical examination and echocardiography were performed on 156 patients: 32 of them (20%) had CVD...
2013: Pan African Medical Journal
Charo Francisco
SESSION TYPE: ILD Global Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Interstitial lung disease (ILD) includes a large, heterogeneous group of mostly rare pulmonary conditions that cause derangements of the alveolar walls and loss of functional alveolar capillary units, consisting of both known and unknown causes that share common histological features. It is influenced by several factors such as host susceptibility, genetics and environmental aspects. Familial ILD is identified by verifying in two or more members of the same family...
October 1, 2012: Chest
Fátima Derlene da Rocha Araújo, Eugênio Marcos Andrade Goulart, Zilda Maria Alves Meira
INTRODUCTION: The diagnosis of acute rheumatic fever (RF) is based on clinical findings. However, during the chronic phase of the disease, the clinical approach is not sufficient for the follow-up of the patients and the Doppler echocardiography is a tool for the diagnosis of cardiac involvement. Prognostic variables that influence long-term outcomes are not well known. METHODS: 462 patients with RF according to Jones criteria were studied, and followed-up from the initial attack to 13...
July 2012: Annals of Pediatric Cardiology
Mona Hafez, Sohier Yahia, Waleed Eldars, Heba Eldegla, Mohamed Matter, Gehan Attia, Samia Hawas
Rheumatic heart disease (RHD) is a chronic condition characterized by fibrosis and scarring of the cardiac valves and damage to the heart muscle, leading to congestive heart failure and death. This prospective cohort study was conducted to investigate the possible relation between the levels of serum adhesion molecules and acute rheumatic fever (ARF) carditis, valvular insult severity, and residual valvular lesion after improvement of rheumatic activity. Serum levels of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin were assayed by enzyme-linked immunoassay (ELISA) for 50 children with ARF carditis during activity and after improvement and for 50 healthy children as control subjects...
March 2013: Pediatric Cardiology
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