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https://www.readbyqxmd.com/read/27921066/review-of-imaging-network-activities-in-developing-rodent-cerebral-cortex-in-vivo
#1
REVIEW
Heiko J Luhmann
The combination of voltage-sensitive dye imaging (VSDI) with multielectrode array (MEA) recordings in the rodent cerebral cortex in vivo allows the simultaneous analysis of large-scale network interactions and electrophysiological single-unit recordings. Using this approach, distinct patterns of spontaneous and sensory-evoked activity can be recorded in the primary somatosensory (S1) and motor cortex (M1) of newborn rats. Already at the day of birth, gamma oscillations and spindle bursts in the barrel cortex synchronize the activity of a local columnar ensemble, thereby generating an early topographic representation of the sensory periphery...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/27920977/neurochemical-changes-in-patients-with-chronic-low-back-pain-detected-by-proton-magnetic-resonance-spectroscopy-a-systematic-review
#2
REVIEW
Xianjing Zhao, Maosheng Xu, Kristen Jorgenson, Jian Kong
BACKGROUND: Low back pain is a highly prevalent health problem around the world, affecting 50% to 85% of people at some point in life. The purpose of this systematic review is to summarize the previous proton magnetic resonance spectroscopy studies on brain chemical changes in patients with chronic low back pain (CLBP). METHODS: We identified relevant studies from a literature search of PubMed and EMBASE from 1980 to March 2016. Data extraction was performed on the subjects' characteristics, MRS methods, spectral analyses, cerebral metabolites and perceptual measurements...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27920668/getting-mirna-therapeutics-into-the-target-cells-for-neurodegenerative-diseases-a-mini-review
#3
REVIEW
Ming Ming Wen
miRNAs play important roles in modulating gene expression in varying cellular processes and disease pathogenesis, including neurodegenerative diseases. Several miRNAs are expressed in the brain, control brain development and are identified as important biomarkers in the pathogenesis of motor-and neuro-cognitive diseases such as Alzheimer's (AD), Huntington's and Parkinson's diseases (PD) and amyotrophic lateral sclerosis. These remarkable miRNAs could be used as diagnostic markers and therapeutic targeting potential for many stressful and untreatable progressive neurodegenerative diseases...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27920664/investigation-of-snp-rs2060546-immediately-upstream-to-ntn4-in-a-danish-gilles-de-la-tourette-syndrome-cohort
#4
Shanmukha S Padmanabhuni, Rayan Houssari, Ann-Louise Esserlind, Jes Olesen, Thomas M Werge, Thomas F Hansen, Birgitte Bertelsen, Fotis Tsetsos, Peristera Paschou, Zeynep Tümer
Gilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. GTS is a complex disorder, with environmental factors and several genes involved. Although variations within a few genes such as AADAC, NRXN1, SLITRK1, HDC, and IMMP2L have been tentatively associated with GTS (in a small number of patients), the causative genes underlying GTS pathophysiology remain unknown. In a previous genome-wide association study (GWAS) a single nucleotide polymorphism (SNP, rs2060546) near the Netrin-4 (NTN4 - MIM 610401) gene was shown to be associated with GTS [odds ratio (OR) = 1...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27920262/home-exercise-programmes-supported-by-video-and-automated-reminders-compared-with-standard-paper-based-home-exercise-programmes-in-patients-with-stroke-a-randomized-controlled-trial
#5
Kellie B Emmerson, Katherine E Harding, Nicholas F Taylor
OBJECTIVE: To determine whether patients with stroke receiving rehabilitation for upper limb deficits using smart technology (video and reminder functions) demonstrate greater adherence to prescribed home exercise programmes and better functional outcomes when compared with traditional paper-based exercise prescription. DESIGN: Randomized controlled trial comparing upper limb home exercise programmes supported by video and automated reminders on smart technology, with standard paper-based home exercise programmes...
December 5, 2016: Clinical Rehabilitation
https://www.readbyqxmd.com/read/27920261/effects-of-repetitive-transcranial-magnetic-stimulation-combined-with-sensory-cueing-on-unilateral-neglect-in-subacute-patients-with-right-hemispheric-stroke-a-randomized-controlled-study
#6
Nicole Yh Yang, Kenneth Nk Fong, Cecilia Wp Li-Tsang, D Zhou
OBJECTIVE: To compare the effects of rTMS combined with sensory cueing, rTMS alone, and conventional rehabilitation on unilateral neglect, hemiplegic arm functions and performance of activities of daily living. DESIGN: A single-blinded randomized controlled trial. SETTING: A convalescent hospital. SUBJECTS: Sixty inpatients with left unilateral neglect after stroke. INTERVENTIONS: Patients were randomly assigned to three groups: rTMS combined with sensory cueing, rTMS, and conventional rehabilitation alone...
December 5, 2016: Clinical Rehabilitation
https://www.readbyqxmd.com/read/27920095/functional-characterization-of-the-left-ventrolateral-premotor-cortex-in-humans-a-direct-electrophysiological-approach
#7
L Fornia, V Ferpozzi, M Montagna, M Rossi, M Riva, F Pessina, F Martinelli Boneschi, P Borroni, R N Lemon, L Bello, G Cerri
In monkeys, motor outputs from premotor cortex (PM) involve cortico-cortical connections with primary motor cortex (M1). However, in humans, the functional organization of PM and its relationship with the corticospinal tract (CST) is still uncertain. This study was carried out in 21 patients undergoing intraoperative brain mapping prior to tumor resection. The left ventrolateral premotor cortex (vlPM-BA6) was identified preoperatively by functional magnetic resonance imaging, and then investigated intraoperatively using high frequency direct electrical stimulation (HF-DES) of the convexity of M1 and vlPM-BA6, with simultaneous recording of motor-evoked potentials (MEPs) from oro-facial, hand and arm muscles...
December 5, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27919862/spinal-cord-injury-assessing-tolerability-and-use-of-combined-rehabilitation-and-neuroaid-saturn-study-protocol-of-an-exploratory-study-in-assessing-the-safety-and-efficacy-of-neuroaid-amongst-people-who-sustain-severe-spinal-cord-injury
#8
Ramesh Kumar, Ohnmar Htwe, Azmi Baharudin, Mohammad Hisam Ariffin, Shaharuddin Abdul Rhani, Kamalnizat Ibrahim, Aishah Rustam, Robert Gan
BACKGROUND: Spinal cord injury (SCI) is a devastating condition with limited therapeutic options despite decades of research. Current treatment options include use of steroids, surgery, and rehabilitation. Nevertheless, many patients with SCI remain disabled. MLC601 (NeuroAiD), a combination of natural products, has been shown to be safe and to aid neurological recovery after brain injuries and may have a potential role in improving recovery after SCI. OBJECTIVE: The aim of this study is to evaluate the safety and efficacy of NeuroAiD amongst people who sustain SCI in the study setting...
December 5, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27919696/the-role-of-anxiety-in-stuttering-evidence-from-functional-connectivity
#9
Yang Yang, Fanlu Jia, Wai Ting Siok, Li Hai Tan
Persistent developmental stuttering is a neurologically based speech disorder associated with cognitive-linguistic, motor and emotional abnormalities. Previous studies investigating the relationship between anxiety and stuttering have yielded mixed results, but it has not yet been examined whether anxiety influences brain activity underlying stuttering. Here, by using functional magnetic resonance imaging (fMRI), we investigated the functional connectivity associated with state anxiety in a syllable repetition task, and trait anxiety during rest in adults who stutter (N=19) and fluent controls (N=19)...
December 2, 2016: Neuroscience
https://www.readbyqxmd.com/read/27919502/motor-fatigability-after-low-intensity-hand-grip-exercises-in-persons-with-multiple-sclerosis
#10
Deborah Severijns, Mieke Lemmens, Ronald Thoelen, Peter Feys
INTRODUCTION: During maximal, sustained contractions, persons with multiple sclerosis (PwMS) show higher motor fatigability in comparison with healthy persons. It is not known if motor fatigability is also different between PwMS and healthy persons during low-intensity exercises. Thus, the aim of this study was to determine the difference in hand grip fatigability between healthy persons and PwMS for both hands during low-intensity hand grip exercises. METHODS: 19 PwMS and 19 healthy controls performed 18min of hand grip exercises at a maximum of 25% of the maximal voluntary strength, with an electronic hand dynamometer...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919416/a-3d-model-of-the-achilles-tendon-to-determine-the-mechanisms-underlying-nonuniform-tendon-displacements
#11
Geoffrey G Handsfield, Joshua M Inouye, Laura C Slane, Darryl G Thelen, G Wilson Miller, Silvia S Blemker
The Achilles is the thickest tendon in the body and is the primary elastic energy-storing component during running. The form and function of the human Achilles is complex: twisted structure, intratendinous interactions, and differential motor control from the triceps surae muscles make Achilles behavior difficult to intuit. Recent in vivo imaging of the Achilles has revealed nonuniform displacement patterns that are not fully understood and may result from complex architecture and musculotendon interactions...
November 28, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27919415/implementation-of-a-mfac-based-position-sensorless-drive-for-high-speed-bldc-motors-with-nonideal-back-emf
#12
Haitao Li, Xin Ning, Wenzhuo Li
In order to improve the reliability and reduce power consumption of the high speed BLDC motor system, this paper presents a model free adaptive control (MFAC) based position sensorless drive with only a dc-link current sensor. The initial commutation points are obtained by detecting the phase of EMF zero-crossing point and then delaying 30 electrical degrees. According to the commutation error caused by the low pass filter (LPF) and other factors, the relationship between commutation error angle and dc-link current is analyzed, a corresponding MFAC based control method is proposed, and the commutation error can be corrected by the controller in real time...
December 2, 2016: ISA Transactions
https://www.readbyqxmd.com/read/27919251/a-randomised-controlled-trial-of-sensory-awareness-training-and-additional-motor-practice-for-learning-scalpel-skills-in-podiatry-students
#13
Ryan S Causby, Michelle N McDonnell, Lloyd Reed, Susan L Hillier
BACKGROUND: The process of using a scalpel, like all other motor activities, is dependent upon the successful integration of afferent (sensory), cognitive and efferent (motor) processes. During learning of these skills, even if motor practice is carefully monitored there is still an inherent risk involved. It is also possible that this strategy could reinforce high levels of anxiety experienced by the student and affect student self-efficacy, causing detrimental effects on motor learning...
December 5, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27918910/altered-dynamics-of-brain-connectivity-in-major-depressive-disorder-at-rest-and-during-task-performance
#14
Fabio Sambataro, Eleonora Visintin, Nadja Doerig, Janis Brakowski, Martin Grosse Holtforth, Erich Seifritz, Simona Spinelli
Major depressive disorder (MDD) has been associated with alterations in several functional brain networks. Previous studies investigating brain networks in MDD during the performance of a task have yielded inconsistent results with the function of the brain at rest. In this study, we used functional magnetic resonance imaging at rest and during a goal-directed task to investigate dynamics of functional connectivity in 19 unmedicated patients with MDD and 19 healthy controls across both experimental paradigms...
November 17, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27918701/coefficient-of-friction-at-the-fingertips-in-type-ii-diabetics-compared-to-healthy-adults
#15
Beatriz H Thames, Stacey L Gorniak
Clinical observations suggests that Type II Diabetes patients are more susceptible to skin changes which may be associated with reduced coefficient of friction at the fingertips. Reduced coefficient of friction may explain recent reports of fine motor dysfunction in diabetic patients. Coefficient of friction was evaluated using slip force evaluation in a cross-sectional cohort of diabetic patients and age- and sex-matched healthy controls. Covariates of tactile sensation, disease duration, glycated hemoglobin, and clinical diagnosis of peripheral neuropathy were also assessed...
December 5, 2016: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/27918413/a-brain-machine-interface-based-on-erd-ers-for-an-upper-limb-exoskeleton-control
#16
Zhichuan Tang, Shouqian Sun, Sanyuan Zhang, Yumiao Chen, Chao Li, Shi Chen
To recognize the user's motion intention, brain-machine interfaces (BMI) usually decode movements from cortical activity to control exoskeletons and neuroprostheses for daily activities. The aim of this paper is to investigate whether self-induced variations of the electroencephalogram (EEG) can be useful as control signals for an upper-limb exoskeleton developed by us. A BMI based on event-related desynchronization/synchronization (ERD/ERS) is proposed. In the decoder-training phase, we investigate the offline classification performance of left versus right hand and left hand versus both feet by using motor execution (ME) or motor imagery (MI)...
December 2, 2016: Sensors
https://www.readbyqxmd.com/read/27918064/cortical-excitability-in-patients-with-resistance-to-thyroid-hormone-compared-to-patients-with-hypothyroidism-and-euthyroid-controls-a-transcranial-magnetic-stimulation-study
#17
C Terranova, V Rizzo, A Calamuneri, L Bartolone, F Morgante, D Bruschetta, V Roberto, P Girlanda, S Benvenga, A Quartarone
Resistance to thyroid hormone (RTH) describes a rare syndrome in which serum levels of thyroid hormones are elevated but serum levels of thyroid stimulating hormone (TSH) are unsuppressed. The importance of thyroid hormones for the normal function of the adult brain is corroborated by the frequent association of thyroid dysfunctions with neurological and psychiatric symptoms. In this study we investigated whether adult thyroid hormone resistance affects cortical excitability and modulates inhibitory and excitatory intracortical circuitries by using transcranial magnetic stimulation...
January 1, 2016: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/27917945/improvement-in-stroke-induced-motor-dysfunction-by-music-supported-therapy-a-systematic-review-and-meta-analysis
#18
Yingshi Zhang, Jiayi Cai, Yaqiong Zhang, Tianshu Ren, Mingyi Zhao, Qingchun Zhao
To conduct a meta-analysis of clinical trials that examined the effect of music-supported therapy on stroke-induced motor dysfunction, comprehensive literature searches of PubMed, Embase and the Cochrane Library from their inception to April 2016 were performed. A total of 10 studies (13 analyses, 358 subjects) were included; all had acceptable quality according to PEDro scale score. The baseline differences between the two groups were confirmed to be comparable. Compared with the control group, the standardized mean difference of 9-Hole Peg Test was 0...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917293/alternative-splicing-of-a-cryptic-exon-embedded-in-intron-6-of-smn1-and-smn2
#19
Satomi Yoshimoto, Nur Imma Fatimah Harahap, Yuko Hamamura, Mawaddah Ar Rochmah, Ai Shima, Naoya Morisada, Masakazu Shinohara, Toshio Saito, Kayoko Saito, Poh San Lai, Masafumi Matsuo, Hiroyuki Awano, Ichiro Morioka, Kazumoto Iijima, Hisahide Nishio
Both survival of motor neuron (SMN) genes are associated with spinal muscular atrophy; mutations in SMN1 cause the disease, and SMN2 modulates its severity. It is established that different alternative splicing of exon 7 occurs for SMN1 and SMN2, and a cryptic exon was recently found in intron 6 of both genes. Here, we characterize this cryptic exon and clarify its alternative splicing pattern in control and spinal muscular atrophy cells.
2016: Human Genome Variation
https://www.readbyqxmd.com/read/27916710/aberrant-regional-homogeneity-in-parkinson-s-disease-a-voxel-wise-meta-analysis-of-resting-state-functional-magnetic-resonance-imaging-studies
#20
REVIEW
PingLei Pan, Hui Zhan, MingXu Xia, Yang Zhang, DeNing Guan, Yun Xu
Studies of abnormal regional homogeneity (ReHo) in Parkinson's disease (PD) have reported inconsistent results. Therefore, we conducted a meta-analysis using the Seed-based d Mapping software package to identify the most consistent and replicable findings. A systematic literature search was performed to identify eligible whole-brain resting-state functional magnetic resonance imaging studies that had measured differences in ReHo between patients with PD and healthy controls between January 2000 and June 4, 2016...
December 1, 2016: Neuroscience and Biobehavioral Reviews
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