Isani Singh, Gillian Noel, Jennifer M Barker, Kathryn C Chatfield, Anna Furniss, Amber D Khanna, Natalie J Nokoff, Sonali Patel, Laura Pyle, Leena Nahata, Francis S Cole, Chijioke Ikomi, Vaneeta Bamba, Patricia Y Fechner, Shanlee M Davis
BACKGROUND & AIMS: Liver disease in children with Turner Syndrome (TS) is poorly understood relative to associated growth, cardiac and reproductive complications. This study sought to better characterize hepatic abnormalities in a large national cohort of youth with TS. METHODS: Using electronic health record data from PEDSnet institutions, 2145 females with TS were matched to 8580 females without TS on eight demographic variables. Outcomes included liver enzymes (AST and ALT) stratified as normal, 1-2 times above the upper limit of normal (ULN), 2-3 times ULN and >3 times ULN, as well as specific liver disease diagnoses...
October 2022: Liver International: Official Journal of the International Association for the Study of the Liver