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Prognostic rheumatic heart disease children

Geneviève Bertaina, Bernard Rouchon, Bertrand Huon, Nina Guillot, Corinne Robillard, Baptiste Noël, Marie Nadra, Christophe Tribouilloy, Eloi Marijon, Xavier Jouven, Mariana Mirabel
CONTEXT AND AIMS: The advent of systematic screening for rheumatic heart disease (RHD) by echocardiography in endemic regions has led to a new entity: borderline RHD. The pathogenicity and natural history of borderline RHD needs to be addressed. The aim of this study was to assess the outcomes of children detected by echocardiography as having borderline RHD. METHODS: Schoolchildren in 4th grade (i.e., aged 9-10years) who were prospectively echo-screened for RHD (2012-2014) in Nouméa, New Caledonia, were asked to participate...
February 1, 2017: International Journal of Cardiology
Mustafa Argun, Ali Baykan, Figen Narin, Abdullah Özyurt, Özge Pamukçu, Ferhan Elmalı, Kazım Üzüm, Nazmi Narin
BACKGROUND: Acute rheumatic fever is an autoimmune, inflammatory, and multi-systemic disease secondary to pharyngitis and is caused by group A streptococcus. In developing countries, acute rheumatic fever is the most common cause of acquired heart disease. Gelsolin is a calcium-dependent, multi-functional actin-regulatory protein circulating in the plasma of healthy human beings. The correlation between blood gelsolin levels and inflammatory conditions suggests the potential benefit of gelsolin as a prognostic marker...
October 2015: Cardiology in the Young
Fátima Derlene da Rocha Araújo, Eugênio Marcos Andrade Goulart, Zilda Maria Alves Meira
INTRODUCTION: The diagnosis of acute rheumatic fever (RF) is based on clinical findings. However, during the chronic phase of the disease, the clinical approach is not sufficient for the follow-up of the patients and the Doppler echocardiography is a tool for the diagnosis of cardiac involvement. Prognostic variables that influence long-term outcomes are not well known. METHODS: 462 patients with RF according to Jones criteria were studied, and followed-up from the initial attack to 13...
July 2012: Annals of Pediatric Cardiology
Luciana Breda, Manuela Nozzi, Sara De Sanctis, Francesco Chiarelli
OBJECTIVES: We reviewed the literature to evaluate the role of common laboratory tests and to examine the recent progress in the laboratory diagnosis of pediatric rheumatic diseases. METHODS: We used the PubMed database (1950-2008) to search for the keywords "laboratory," "erythrocyte sedimentation rate" (ESR), "C-reactive protein" (CRP), "blood cytology," "procalcitonin" (PCT), "complement system," "ferritin," "antistreptolysin O titer" (ASO), "autoantibodies," "genetic studies," in conjunction with "rheumatic disease in children" and "pediatric autoimmune diseases...
August 2010: Seminars in Arthritis and Rheumatism
S I Omokhodion, I A Lagunju
OBJECTIVES: To evaluate the short term prognosis of childhood heart failure and highlight the factors that affect outcome among cases of heart failure admitted into the paediatric wards, University College Hospital, Ibadan. BACKGROUND: Childhood heart failure remains a major cause of morbidity and mortality in the developing world. The advent of open heart surgery, use of better myocardial preservative techniques, and the introduction of newer, more effective drugs in the treatment of heart failure have greatly improved the outcome of children with heart failure in the developed world...
October 2005: West African Journal of Medicine
No abstract text is available yet for this article.
July 1952: Pediatriia
Dursun Alehan, Süheyla Ozkutlu, Canan Ayabakan, Arman Bilgiç, Sencan Ozme, Sema Ozer, Alpay Celiker
We retrospectively assessed the clinical course and outcome of left-sided endocarditis in pediatric patients to find out the prognostic significance of the presence and size of echocardiographically detected vegetations. Among the children admitted to our institution with endocarditis between January 1987 and October 1999, 16 patients (mean age 9.03 +/- 4.95 years) who met the Duke criteria for the diagnosis of infective endocarditis (IE) were included in this study. Rheumatic valvular disease was the most frequent underlying heart disease (10 patients: 62...
January 2002: Turkish Journal of Pediatrics
J Ardura, A Khatib, S Torres, F Gimeno, L Serrano
Authors report results of the study of a series of rheumatic heart disease in 34 children between three and 14 years old, followed-up from one month to 14 years (mean six years and six months), and another one of 14 adults operated because of cardiac sequelae, in whom the average age was 48. The most significant results are: more common in autumn-winter (62%) and females (60%); family history of rheumatic fever (55%); low social level; mitral predominance with mitral regurgitation in children and stenosis in adults; during puberty age; without symptoms in the joints in 36%, and with better prognosis since 1974...
August 1981: Anales Españoles de Pediatría
F Jaiyesimi, A U Antia
Forty-eight Nigerian children (M = 22, F = 26; mean age = 6 years) With rheumatic heart disease (RHD) were studied prospectively. Three years after the initial presentation 12 of them (25%) had improved, 14 (29%) remained about the same while 22 (46%) had either deteriorated or died. A poor socio-economic background, delay in seeking medical treatment, and recurrence of acute rheumatic fever (ARF) all adversely affected the prognosis. Similarly mitral stenosis, multiple valve lesions, pulmonary hypertension, and subacute bacterial endocarditis (SBE) were associated with a poor prognosis...
March 1981: Tropical and Geographical Medicine
M Ben Ismail, N Kafsi, B Cormier, S Trabelsi
The authors report the long-term results of 309 patients undergoing isolated mitral valve replacement with a 6120 Starr Edwards mitral valve prosthesis in the great majority of cases, mainly for rheumatic mitral valve disease, with predominant mitral regurgitation. The average age was 26 +/- 14 years with 25% of children. The operative mortality was 9% and late mortality after a mean follow-up period of 4 years was 13,5% mainly due to thromboembolic complications and to myocardial dysfunction. The long-term results with an average 45 month follow-up showed a 10 year survival rate of 70,6% with an excellent clinical result in 71% of cases and an acceptable result in 10%; 20% of patients were considered poor long-term results because of myocardial dysfunction and thromboembolic complications...
August 1984: Archives des Maladies du Coeur et des Vaisseaux
H A Majeed, A M Yousof, F A Khuffash, A R Yusuf, S Farwana, N Khan
One hundred and twenty-six children with the initial attack of acute rheumatic fever were followed up prospectively for 6 years. Sixty-six children maintained regular secondary prophylaxis (regular group) and 60 were irregular (irregular group). Two recurrences developed in the regular group with a recurrence rate of 0.005/patient/year follow-up, and 71 recurrences developed in the irregular group with a recurrence rate of 0.2/patient/year follow-up. These findings demonstrate the effect of secondary prophylaxis in reducing the frequency of recurrences...
1986: Journal of Chronic Diseases
T Onat, G Ahunbay
Acute rheumatic isolated mitral regurgitation was followed up in 86 children for 730 patient-years. The grade of severity of regurgitation was classified according to degree of left ventricular enlargement, which was based on an original method of correction of cardiothoracic ratio on the chest x-ray, taking into consideration the diaphragmatic level, and electrocardiographic criteria for age. A combination of both quantitative estimations, after the regression of a detectable pericardial effusion reduced false-positive radiologic and false-negative electrocardiographic results...
July 1989: Turkish Journal of Pediatrics
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