Jill A Poole, Kathryn E Cole, Geoffrey M Thiele, James E Talmadge, Bryant R England, Amy J Nelson, Angela Gleason, Aaron Schwab, Rohit Gaurav, Michael J Duryee, Kristina L Bailey, Debra J Romberger, Daniel Hershberger, Joel Van De Graaff, Sara M May, Rhonda Walenz, Bridget Kramer, Ted R Mikuls
OBJECTIVES: Interstitial lung disease (ILD) is associated with significant mortality in rheumatoid arthritis (RA) patients with key cellular players remaining largely unknown. This study aimed to characterize inflammatory and myeloid derived suppressor cell (MDSC) subpopulations in RA-ILD as compared to RA, idiopathic pulmonary fibrosis (IPF) without autoimmunity, and controls. METHODS: Peripheral blood was collected from patients with RA, RA-ILD, IPF, and controls (N = 60, 15/cohort)...
December 11, 2023: International Immunopharmacology