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Heart failure children rct

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https://www.readbyqxmd.com/read/27380530/propranolol-reduces-cardiac-index-but-does-not-adversely-affect-peripheral-perfusion-in-severely-burned-children
#1
Paul Wurzer, Ludwik K Branski, Robert P Clayton, Gabriel Hundeshagen, Abigail A Forbes, Charles D Voigt, Clark R Andersen, Lars-P Kamolz, Lee C Woodson, Oscar E Suman, Celeste C Finnerty, David N Herndon
PURPOSE: The aim of this study was to quantify the effect of propranolol on hemodynamic parameters assessed using the PiCCO system in burned children. METHODS: We analyzed hemodynamic data from patients who were randomized to receive either propranolol (4 mg/kg/day) or placebo (control), which was initiated as a prospective randomized controlled trial. Endpoints were cardiac index (CI), percent predicted heart rate (%HR), mean arterial pressure (MAP), percent predicted stroke volume (%SV), rate pressure product (RPP), cardiac work (CW), systemic vascular resistance index (SVRI), extravascular lung water index (EVLWI), arterial blood gases, events of lactic acidosis, and mortality...
November 2016: Shock
https://www.readbyqxmd.com/read/27229908/rescue-sedation-with-intranasal-dexmedetomidine-for-pediatric-ophthalmic-examination-after-chloral-hydrate-failure-a-randomized-controlled-trial
#2
Xiaoliang Gan, Haotian Lin, Jingjing Chen, Zhuoling Lin, Yiquan Lin, Weirong Chen
PURPOSE: It is a challenge to rescue ophthalmology examinations performed in children in the sedation room after initial chloral hydrate failure. Intranasal dexmedetomidine can be used in rescue sedation in children undergoing computed tomography. The present study aimed to assess the efficacy and tolerability of intranasal dexmedetomidine use in children undergoing ophthalmic examination after chloral hydrate failure. METHODS: Sixty uncooperative pediatric patients with cataract (aged 5-36 months; weight, 7-15 kg) presented for follow-up ophthalmic examination...
June 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/26938118/different-dosage-schedules-for-reducing-cardiotoxicity-in-people-with-cancer-receiving-anthracycline-chemotherapy
#3
REVIEW
Elvira C van Dalen, Helena J H van der Pal, Leontien C M Kremer
BACKGROUND: This review update has been managed by both the Childhood Cancer and Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Groups.The use of anthracycline chemotherapy is limited by the occurrence of cardiotoxicity. To prevent this cardiotoxicity, different anthracycline dosage schedules have been studied. OBJECTIVES: To determine the occurrence of cardiotoxicity with the use of different anthracycline dosage schedules (that is peak doses and infusion durations) in people with cancer...
March 3, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26820557/beta-blockers-for-congestive-heart-failure-in-children
#4
REVIEW
Samer Alabed, Ammar Sabouni, Suleiman Al Dakhoul, Yamama Bdaiwi, Anne-Kristina Frobel-Mercier
BACKGROUND: Beta-blockers are an essential part of standard therapy in adult congestive heart failure and therefore, are expected to be beneficial in children. However, congestive heart failure in children differs from that in adults in terms of characteristics, aetiology, and drug clearance. Therefore, paediatric needs must be specifically investigated. This is an update of a Cochrane review previously published in 2009. OBJECTIVES: To assess the effect of beta-adrenoceptor-blockers (beta-blockers) in children with congestive heart failure...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25198738/the-role-of-beta-blocker-in-heart-failure-in-adults-with-congenital-heart-disease
#5
REVIEW
Kambiz Norozi
Thanks to the enormous progress in the field of cardiac surgery and paediatric cardiology since the mid of 20th century, more and more children with congenital heart defects reach the adulthood. This on the other hand encounter physician and patients various problems due to late complications after the heart surgery like congestive heart failure, arrhythmia and sudden death. One of the challenging area is the medical management of heart failure in these patients with complex anatomy and hemodynamics. The lack of evidence of the effectiveness of the anti congestive medications in this population in from of large randomized controlled trials, makes it difficult to establish universally accepted therapy guidelines...
2014: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/24493806/update-on-pharmacological-heart-failure-therapies-in-children-do-adult-medications-work-in-children-and-if-not-why-not
#6
REVIEW
Joseph W Rossano, Robert E Shaddy
No abstract text is available yet for this article.
February 4, 2014: Circulation
https://www.readbyqxmd.com/read/24356284/high-frequency-oscillatory-ventilation-for-early-acute-respiratory-distress-syndrome-in-adults
#7
REVIEW
Alberto Goffi, Niall D Ferguson
PURPOSE OF REVIEW: High-frequency oscillatory ventilation (HFOV) has been considered a potentially ideal mode of lung-protective ventilation. A recent meta-analysis suggested improved oxygenation and reduced mortality in adults and children with acute respiratory distress syndrome (ARDS), but the use of outdated control strategies and small numbers of patients in many of the studies rendered these findings hypothesis-generating only. RECENT FINDINGS: During 2013, two large randomized controlled trials comparing HFOV with a conventional lung-protective ventilation were published - the Oscillation for Acute Respiratory Distress Syndrome Treated Early (OSCILLATE) and the Oscillation in ARDS (OSCAR) trials...
February 2014: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/24176784/2013-syr-accepted-poster-abstracts
#8
RANDOMIZED CONTROLLED TRIAL
(no author information available yet)
SYR 2013 Accepted Poster abstracts: 1. Benefits of Yoga as a Wellness Practice in a Veterans Affairs (VA) Health Care Setting: If You Build It, Will They Come? 2. Yoga-based Psychotherapy Group With Urban Youth Exposed to Trauma. 3. Embodied Health: The Effects of a Mind�Body Course for Medical Students. 4. Interoceptive Awareness and Vegetable Intake After a Yoga and Stress Management Intervention. 5. Yoga Reduces Performance Anxiety in Adolescent Musicians. 6. Designing and Implementing a Therapeutic Yoga Program for Older Women With Knee Osteoarthritis...
2013: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/24014205/inspiratory-muscle-training-for-asthma
#9
REVIEW
Ivanizia S Silva, Guilherme A F Fregonezi, Fernando A L Dias, Cibele T D Ribeiro, Ricardo O Guerra, Gardenia M H Ferreira
BACKGROUND: In some people with asthma, expiratory airflow limitation, premature closure of small airways, activity of inspiratory muscles at the end of expiration and reduced pulmonary compliance may lead to lung hyperinflation. With the increase in lung volume, chest wall geometry is modified, shortening the inspiratory muscles and leaving them at a sub-optimal position in their length-tension relationship. Thus, the capacity of these muscles to generate tension is reduced. An increase in cross-sectional area of the inspiratory muscles caused by hypertrophy could offset the functional weakening induced by hyperinflation...
2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/23904337/efficacy-of-sublingual-lorazepam-versus-intrarectal-diazepam-for-prolonged-convulsions-in-sub-saharan-africa
#10
RANDOMIZED CONTROLLED TRIAL
Célestin Kaputu Kalala Malu, Daniel Mukeba Kahamba, Timothy David Walker, Caritas Mukampunga, Eric Mafuta Musalu, Jacques Kokolomani, Richard Mukendi Kavulu Mayamba, Jo M Wilmshurst, Jean-Marie Dubru, Jean-Paul Misson
In Sub-Saharan Africa, intrarectal diazepam is the first-line anticonvulsant mostly used in children. We aimed to assess this standard care against sublingual lorazepam, a medication potentially as effective and safe, but easier to administer. A randomized controlled trial was conducted in the pediatric emergency departments of 9 hospitals. A total of 436 children aged 5 months to 10 years with convulsions persisting for more than 5 minutes were assigned to receive intrarectal diazepam (0.5 mg/kg, n = 202) or sublingual lorazepam (0...
July 2014: Journal of Child Neurology
https://www.readbyqxmd.com/read/23463133/tolvaptan-increases-serum-sodium-in-pediatric-patients-with-heart-failure
#11
COMPARATIVE STUDY
Rebecca B Regen, Ashley Gonzalez, Kasey Zawodniak, David Leonard, Raymond Quigley, Aliessa P Barnes, Joshua D Koch
This study aimed to evaluate the use of tolvaptan in a consecutive series of pediatric patients with heart failure. Patients 18 years of age or younger with heart failure prescribed tolvaptan between January 2009 and October 2011 were retrospectively identified at Children's Medical Center Dallas. Laboratory parameters, urine output, fluid balance, and concurrent medications were recorded at baseline and at specified intervals after a single dose of tolvaptan. The 28 patients in the study had a median age of 2 years (range 1 month-18 years)...
August 2013: Pediatric Cardiology
https://www.readbyqxmd.com/read/23074453/left-ventricular-assist-devices-an-evidence-based-analysis
#12
(no author information available yet)
OBJECTIVE: The objective of this health technology policy assessment was to determine the effectiveness and cost-effectiveness of using implantable ventricular assist devices in the treatment of end-stage heart failure. HEART FAILURE: Heart failure is a complex syndrome that impairs the ability of the heart to maintain adequate blood circulation, resulting in multiorgan abnormalities and, eventually, death. In the period of 1994 to 1997, 38,702 individuals in Ontario had a first hospital admission for heart failure...
2004: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/23050818/use-of-the-cardioprotectants-thymosin-%C3%AE-4-and-dexrazoxane-during-congenital-heart-surgery-proposal-for-a-randomized-double-blind-clinical-trial
#13
Daniel Stromberg, Tia Raymond, David Samuel, David Crockford, William Stigall, Steven Leonard, Eric Mendeloff, Andrew Gormley
Neonates and infants undergoing heart surgery with cardioplegic arrest experience both inflammation and myocardial ischemia-reperfusion (IR) injury. These processes provoke myocardial apoptosis and oxygen-free radical formation that result in cardiac injury and dysfunction. Thymosin β4 (Tβ4) is a naturally occurring peptide that has cardioprotective and antiapoptotic effects. Similarly, dexrazoxane provides cardioprotection by reduction of toxic reactive oxygen species (ROS) and suppression of apoptosis. We propose a pilot pharmacokinetic/safety trial of Tβ4 and dexrazoxane in children less than one year of age, followed by a randomized, double-blind, clinical trial of Tβ4 or dexrazoxane versus placebo during congenital heart surgery...
October 2012: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/22895944/short-term-late-generation-antibiotics-versus-longer-term-penicillin-for-acute-streptococcal-pharyngitis-in-children
#14
REVIEW
Saleh Altamimi, Adli Khalil, Khalid A Khalaiwi, Ruth A Milner, Martin V Pusic, Mohammed A Al Othman
BACKGROUND: The standard duration of treatment for children with acute group A beta hemolytic streptococcus (GABHS) pharyngitis with oral penicillin is 10 days. Shorter duration antibiotics may have comparable efficacy. OBJECTIVES: To summarize the evidence regarding the efficacy of two to six days of newer oral antibiotics (short duration) compared to 10 days of oral penicillin (standard duration) in treating children with acute GABHS pharyngitis. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL 2012, Issue 3) which contains the Cochrane Acute Respiratory Infections Group's Specialized Register, MEDLINE (January 1966 to March week 3, 2012) and EMBASE (January 1990 to April 2012)...
2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/22683686/parenteral-%C3%AF-3-fatty-acid-lipid-emulsions-for-children-with-intestinal-failure-and-other-conditions-a-systematic-review
#15
Jennifer C Seida, Diana R Mager, Lisa Hartling, Ben Vandermeer, Justine M Turner
BACKGROUND: There is growing interest in the use of ω-3 fatty acid (n-3FA) lipid emulsions to prevent complications associated with parenteral nutrition. The authors systematically reviewed the evidence on the benefits and safety of n-3FA compared with standard lipid emulsions in children with intestinal disease, critical illness, trauma, or postoperative complications. MATERIALS AND METHODS: The authors searched 4 bibliographic databases from their inception to March 2011, conference proceedings, trial registries, and reference lists...
January 2013: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/21678342/cardioprotective-interventions-for-cancer-patients-receiving-anthracyclines
#16
REVIEW
Elvira C van Dalen, Huib N Caron, Heather O Dickinson, Leontien Cm Kremer
BACKGROUND: Anthracyclines are among the most effective chemotherapeutic agents in the treatment of numerous malignancies. Unfortunately, their use is limited by a dose-dependent cardiotoxicity. In an effort to prevent this cardiotoxicity, different cardioprotective agents have been studied. OBJECTIVES: The objective of this review was to assess the efficacy of different cardioprotective agents in preventing heart damage in cancer patients treated with anthracyclines...
2011: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/21253815/the-role-of-vasopressin-and-terlipressin-in-catecholamine-resistant-shock-and-cardio-circulatory-arrest-in-children-review-of-the-literature
#17
REVIEW
Sascha Meyer, William McGuire, Sven Gottschling, Ghiath Mohammed Shamdeen, Ludwig Gortner
INTRODUCTION: Arginine-vasopressin (AVP) and terlipressin (TP) are used as rescue drugs for states of shock and cardio-circulatory failure. METHODS: Review to assess AVP/TP as a rescue therapy in children with catecholamine-resistant shock or cardio-circulatory arrest. RESULTS: A total of 31 reports were included (428 patients); sixteen articles were case series, 10 case reports, 3 clinical evaluation studies, one study was a non-blind RCT while one study was a multicentre double-blind RCT...
April 2011: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/21048239/acute-respiratory-distress-syndrome
#18
REVIEW
Priya Prabhakaran
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a common diagnosis among children admitted to pediatric intensive care units. This heterogeneous disorder has numerous pulmonary and non-pulmonary causes and is associated with a significant risk of mortality. Many supportive therapies exist for ARDS. SEARCH: Literature search was performed by using the key words ARDS and related topics on the Pubmed search engine maintained by the National Heart, Lung, Blood Institute. Pediatric randomized controlled trials that have been published in the last 10 years were included...
October 2010: Indian Pediatrics
https://www.readbyqxmd.com/read/20619024/-dexrazoxane-in-anthracycline-induced-cardiotoxicity-and-extravasation
#19
REVIEW
Andrew K L Goey, Jan H M Schellens, Jos H Beijnen, Alwin D R Huitema
Cardiotoxicity and extravasation injuries are extremely serious complications of anthracycline use. Both complications are probably caused by oxidative stress. Dexrazoxane has been approved as a cardioprotective agent and as an antidote in extravasation of anthracyclines. Randomized clinical trials have shown that dexrazoxane is the only cardioprotective agent proven to be effective in the treatment of anthracycline-induced cardiotoxicity. In these clinical studies dexrazoxane decreased the incidence of cardiac events and heart failure...
2010: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/20573993/bnp-levels-predict-outcome-in-pediatric-heart-failure-patients-post-hoc-analysis-of-the-pediatric-carvedilol-trial
#20
Scott R Auerbach, Marc E Richmond, Jacqueline M Lamour, Elizabeth D Blume, Linda J Addonizio, Robert E Shaddy, Lynn Mahony, Elfriede Pahl, Daphne T Hsu
BACKGROUND: The ability of serum B-type natriuretic peptide levels (BNP) to predict outcomes in children with heart failure (HF) has not been well demonstrated. This study was designed to determine whether BNP levels predict outcomes in patients with moderate symptomatic HF. METHODS AND RESULTS: We investigated whether enrollment BNP levels for the Pediatric Carvedilol Trial were associated with baseline characteristics. Freedom from a composite end point of HF hospitalization, death, or transplantation at 9 months was compared using a threshold BNP level identified using receiver operating curve analysis...
September 2010: Circulation. Heart Failure
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