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https://www.readbyqxmd.com/read/29041892/-randomized-controlled-trials-in-patients-with-heart-failure-in-russia-following-the-study-topcat-what-awaits-us-in-the-future
#1
M Y Lopatin
No abstract text is available yet for this article.
August 2017: Kardiologiia
https://www.readbyqxmd.com/read/29037211/pioglitazone-and-the-secondary-prevention-of-cardiovascular-disease-a-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Marit de Jong, H Bart van der Worp, Yolanda van der Graaf, Frank L J Visseren, Jan Westerink
BACKGROUND AND AIMS: Pioglitazone targets multiple pathogenic pathways involved in the development of cardiovascular diseases (CVD). The aim of this systematic review and meta-analysis is to assess the effects of pioglitazone treatment on the secondary prevention of CVD. METHODS: Randomized-controlled trials of pioglitazone in patients with CVD were identified through PubMed, Embase, Cochrane and CINAHL, in a search up to May 2016. Studies were included if pioglitazone was compared with any control (usual care, placebo or active comparator) and if patients were previously diagnosed with CVD...
October 16, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29020435/blood-pressure-targets-for-the-treatment-of-people-with-hypertension-and-cardiovascular-disease
#3
REVIEW
Luis Carlos Saiz, Javier Gorricho, Javier Garjón, Mª Concepción Celaya, Lourdes Muruzábal, Mª Del Mar Malón, Rodolfo Montoya, Antonio López
BACKGROUND: Hypertension is a prominent preventable cause of premature morbidity and mortality. People with hypertension and established cardiovascular disease are at particularly high risk, so reducing blood pressure below standard targets may be beneficial. This strategy could reduce cardiovascular mortality and morbidity but could also increase adverse events. The optimal blood pressure target in people with hypertension and established cardiovascular disease remains unknown. OBJECTIVES: To determine if 'lower' blood pressure targets (≤ 135/85 mmHg) are associated with reduction in mortality and morbidity as compared with 'standard' blood pressure targets (≤ 140 to 160/ 90 to 100 mmHg) in the treatment of people with hypertension and a history of cardiovascular disease (myocardial infarction, angina, stroke, peripheral vascular occlusive disease)...
October 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29018938/heart-failure-with-preserved-ejection-fraction-current-management-and-future-strategies-expert-opinion-on-the-behalf-of-the-nucleus-of-the-heart-failure-working-group-of-the-german-society-of-cardiology-dkg
#4
REVIEW
Carsten Tschöpe, Christoph Birner, Michael Böhm, Oliver Bruder, Stefan Frantz, Andreas Luchner, Lars Maier, Stefan Störk, Behrouz Kherad, Ulrich Laufs
About 50% of all patients suffering from heart failure (HF) exhibit a reduced ejection fraction (EF ≤ 40%), termed HFrEF. The others may be classified into HF with midrange EF (HFmrEF 40-50%) or preserved ejection fraction (HFpEF, EF ≥ 50%). Presentation and pathophysiology of HFpEF is heterogeneous and its management remains a challenge since evidence of therapeutic benefits on outcome is scarce. Up to now, there are no therapies improving survival in patients with HFpEF. Thus, the treatment targets symptom relief, quality of life and reduction of cardiac decompensations by controlling fluid retention and managing risk factors and comorbidities...
October 10, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29017565/safety-and-efficacy-of-qishen-granules-in-patients-with-chronic-heart-failure-study-protocol-for-a-randomized-controlled-trial
#5
Jinping Wang, Jun Shi, Jiawei Wei, Juan Wang, Kuo Gao, Xueli Li, Jianxin Chen, Shaojing Li, Huihui Zhao, Wei Wang
BACKGROUND: Chronic heart failure (CHF), the final stage of various cardiovascular diseases, is a major public health problem resulting in significant hospitalization rates, mortality, and huge health care costs despite advances in the treatment and management of heart failure and heart failure-related risk factors. Qishen granules (QSG), a Chinese herbal formula, is widely used by traditional Chinese medicine (TCM) practitioners to treat CHF. Several animal experimental studies have showed that QSG can significantly relieve the heart failure symptoms in CHF rat models...
October 10, 2017: Trials
https://www.readbyqxmd.com/read/28992172/points-to-consider-in-renal-involvement-in-systemic-sclerosis
#6
REVIEW
Felice Galluccio, Ulf Müller-Ladner, Daniel E Furst, Dinesh Khanna, Marco Matucci-Cerinic
This article discusses points to consider when undertaking a clinical trial to test therapy for renal involvement in SSc, not including scleroderma renal crisis. Double-blind, randomized controlled trials vs placebo or standard background therapy should be strongly considered. Inclusion criteria should consider a pre-specified range of renal functions or stratification of renal function. Gender and age limitations are probably not necessary. Concomitant medications including vasodilators, immunosuppressants and endothelin receptor antagonists and confounding illnesses such as diabetes, kidney stones, hypertension and heart failure need to be considered...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28986727/dpp-4-inhibitors-and-heart-failure-a-potential-role-for-pharmacogenomics
#7
REVIEW
Chayakrit Krittanawong, Andrew Xanthopoulos, Takeshi Kitai, Natalia Branis, HongJu Zhang, Marrick Kukin
There remains an ongoing controversy regarding the safety of dipeptidyl peptidase-4 (DPP-4) inhibitors and the risk of developing heart failure (HF). In addition, none of the animal studies suggested a mechanism for the DPP-4 inhibitors and HF risk. To date, advances in pharmacogenomics have enabled the identification of genetic variants in DPP-4 gene. Studies have shown that genetic polymorphisms in the gene encoding DPP-4 may be associated with potential pathways involved in HF risk. This review discusses the contradictory findings of DPP-4 inhibitors and HF and a potential role for pharmacogenomics...
October 6, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28982370/effect-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-ii-receptor-blockers-on-cardiovascular-events-in-patients-with-heart-failure-a-meta-analysis-of-randomized-controlled-trials
#8
Chenhui Tai, Tianyi Gan, Liling Zou, Yuxi Sun, Yi Zhang, Wei Chen, Jue Li, Jian Zhang, Yawei Xu, Huihe Lu, Dachun Xu
BACKGROUND: Heart failure (HF) remains a significant cause of morbidity and mortality. Multiple trials over the past several years have examined the effects of both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) in the treatment of left ventricular dysfunction, both acutely after myocardial infarction and in chronic heart failure. Yet, there is still confusion regarding the relative efficacy of rennin-angiotensin-aldosterone system (RAAS) inhibition...
October 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28974553/safety-and-efficacy-of-the-intravenous-infusion-of-umbilical-cord-mesenchymal-stem-cells-in-patients-with-heart-failure-a-phase-1-2-randomized-controlled-trial-rimecard-trial
#9
Jorge G Bartolucci, Fernando J Verdugo, Paz L González, Ricardo E Larrea, Ema Abarzua, Carlos Goset, Pamela G Rojo, Ivan Palma, Ruben Lamich, Pablo A Pedreros, Gloria Valdivia, Valentina M Lopez, Carolina Nazzal, Francisca Alcayaga, Jimena Cuenca, Matthew J Brobeck, Amit N Patel, Fernando E Figueroa, Maroun Khoury
Rationale: Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease. While bone marrow-derived mesenchymal stem cells (BM-MSCs) have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction (HFrEF), no clinical trial has evaluated UC-MSCs in these patients. Objective: Evaluate the safety and efficacy of the infusion of UC-MSC in patients with chronic stable HFrEF...
September 26, 2017: Circulation Research
https://www.readbyqxmd.com/read/28964433/cost-effectiveness-analysis-of-natriuretic-peptide-testing-and-specialist-management-in-patients-with-suspected-acute-heart-failure
#10
Edward A Griffin, David Wonderling, Andrew J Ludman, Abdallah Al-Mohammad, Martin R Cowie, Suzanna M C Hardman, John J V McMurray, Jason Kendall, Polly Mitchell, Aminat Shote, Katharina Dworzynski, Jonathan Mant
OBJECTIVES: To determine the cost-effectiveness of natriuretic peptide (NP) testing and specialist outreach in patients with acute heart failure (AHF) residing off the cardiology ward. METHODS: We used a Markov model to estimate costs and quality-adjusted life-years (QALYs) for patients presenting to hospital with suspected AHF. We examined diagnostic workup with and without the NP test in suspected new cases, and we examined the impact of specialist heart failure outreach in all suspected cases...
September 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28958751/insulin-therapy-increases-cardiovascular-risk-time-for-a-sea-of-change-in-type-2-diabetes-treatment
#11
REVIEW
Mary E Herman, James H O'Keefe, David S H Bell, Stanley S Schwartz
Insulin therapy increased cardiovascular (CV) risk and mortality among type 2 diabetes (T2D) patients in several recently reported clinical outcomes trials. To assess whether this association is causative or coincidental, PubMed searches were used to query the effects of insulin therapy for T2D on CV health and longevity from large-scale outcomes trials, meta-analyses, and patient registry studies, as well as basic research on insulin's direct and pleiotropic actions. Although several old studies provided conflicting results, the majority of large observational studies show strong dose-dependent associations for injected insulin with increased CV risk and worsened mortality...
September 25, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28953668/huangqi-injection-in-the-treatment-of-chronic-heart-failure-a-systematic-review-and-meta-analysis
#12
REVIEW
Kaihuan Wang, Jiarui Wu, Xiaojiao Duan, Jiatao Wu, Dan Zhang, Xiaomeng Zhang, Bing Zhang
BACKGROUND: To evaluate the clinical effectiveness and safety of Huangqi injection (HI) in treating chronic heart failure (CHF) systematically. METHODS: A literature search was conducted for retrieving randomized controlled trials (RCTs) on CHF treated by HI in the Cochrane Library, PubMed, Embase, China Biology Medicine disc, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang Database up to June, 6, 2017, and then the included RCTs were assessed by the Cochrane Risk of Bias Assessment Tool...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28950829/statins-and-left-ventricular-function
#13
Agamemnon Bakakos, Evangelos Oikonomou, Georgia Vogiatzi, Gerasimos Siasos, Sotiris Tsalamandris, Alexios Antonopoulos, Costas Mourouzis, Petros Fountoulakis, Manolis Vavuranakis, Dimitris Tousoulis
BACKGROUND: Statins are a well-established class of drugs in both preventing coronary events and treating cardiovascular atherosclerotic disease, however their use in heart failure is still in debate. OBJECTIVES: To establish whether statins' pleiotropic actions in endothelium, inflammation, remodeling of the heart and anti-arrhythmic potential may be in favorable of heart failure patients. METHODS: We proceed to literature search of English bibliography under the terms heart failure, statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors...
September 26, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28939459/comparative-effectiveness-of-telemonitoring-versus-usual-care-for-heart-failure-a-systematic-review-and-meta-analysis
#14
Ji Eun Yun, Jeong-Eun Park, Hyun-Young Park, Hae-Young Lee, Dong Ah Park
BACKGROUND: This study aimed to evaluate the effectiveness of telemonitoring (TM) in the management of patients with heart failure (HF). METHODS AND RESULTS: We searched Ovid-Medline, Ovid-EMBASE, and the Cochrane Library for randomized controlled trials published through April 2016. Outcomes of interest included clinical effectiveness (mortality, hospitalization, and emergency room visits) and patient-reported outcomes. TM was defined as the transmission of individual biological data such as weight, blood pressure, and heart rate...
September 19, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28939458/mind-body-interventions-for-individuals-with-heart-failure-a-systematic-review-of-randomized-trials
#15
REVIEW
Zehra Gok Metin, Deborah Ejem, J Nicholas Dionne-Odom, Yasemin Turkman, Carolina Salvador, Salpy Pamboukian, Marie Bakitas
BACKGROUND: The effects of mind-body interventions (MBIs) (e.g. Tai Chi, yoga, and meditation) for individuals with heart failure (HF) have not been systematically evaluated. METHODS AND RESULTS: We performed a systematic review of randomized controlled trials (RCTs) examining the effects of MBIs in HF. We extracted participant characteristics, MBI procedure, outcomes assessed, and main results of English language RCTs before October 2016. We identified 24 RCTs (n=1314 participants) of nine MBI types: Tai Chi (n=7), yoga (n =4), relaxation (n =4), meditation (n=2), acupuncture (n=2), biofeedback (n=2), stress management (n=1), Pilates (n=1) and reflexology (n=1)...
September 19, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28935393/the-effectiveness-of-psychological-interventions-on-self-care-psychological-and-health-outcomes-in-patients-with-chronic-heart-failure-a-systematic-review-and-meta-analysis
#16
REVIEW
Ying Jiang, Shefaly Shorey, Betsy Seah, Wanxian Chan, Wilson Wai San Tam, Wenru Wang
OBJECTIVE: To review the evidence to determine the effects of psychological interventions on self-care and psychological and health outcomes in patients with chronic heart failure (CHF). METHODS: We evaluated the effectiveness of randomized controlled trials using psychological methods or theory on self-care behaviors, anxiety and depression levels, HRQoL, and physical function. Studies published in English, from January 2006 to December 2016, were considered. We searched published and unpublished studies in the following electronic databases: CINAHL, Cochrane Library, EMBASE, PubMed, PsycINFO, Scopus, Web of Science, and ProQuest Dissertations and Theses...
August 19, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28925168/-meta-analysis-of-supplemented-zhenwu-decoction-for-treating-congestive-heart-failure
#17
Yuan-Ping Wang, Jie Xiong, Xia Yan, Xiao-Hui Li, Zi-Qing Luo
The paper was to systematically evaluate the clinical efficacy of supplemented Zhenwu decoction for treating congestive heart-failure. Three foreign language databases including the Cochrane Library, PubMed, EMbase and four Chinese databases including CBM, CNKI, VIP and Wanfang Database were retrieved from their establishment to July 2016 for all randomized control trials(RCTs) on supplemented Zhenwu decoction in treatment of congestive heart-failure. The references in the included RCTs were also traced. Literature selection and information extraction was completed and screened by two independent reviewers, and Meta-analysis was performed by using RevMan 5...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28916152/effects-of-inspiratory-muscle-training-on-cardiovascular-autonomic-control-a-systematic-review
#18
REVIEW
Raphael Martins de Abreu, Patrícia Rehder-Santos, Vinicius Minatel, Gabriela Lopes Dos Santos, Aparecida Maria Catai
PURPOSE: To carry out a systematic review to determine if inspiratory muscle training (IMT) promotes changes in cardiovascular autonomic responses in humans. METHODS: The methodology followed the PRISMA statement for reporting systematic review analysis. MEDLINE, PEDro, SCOPUS and PubMed electronic databases were searched from the inception to March 2017. The quality assessment was performed using a PEDro scale. The articles were included if: (1) primary objective was related to the effects of IMT on the cardiovascular autonomic nervous system, and (2) randomized clinical trials and quasi-experimental studies...
September 7, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28912263/hemodynamic-phenotyping-of-pulmonary-hypertension-in-left-heart-failure
#19
REVIEW
Robert Naeije, Mario Gerges, Jean-Luc Vachiery, Sergio Caravita, Christian Gerges, Irene M Lang
Increased pulmonary venous pressure secondary to left heart disease is the most common cause of pulmonary hypertension (PH). The diagnosis of PH due to left heart disease relies on a clinical probability assessment followed by the invasive measurements of a mean pulmonary artery pressure (PAP) ≥25 mm Hg and mean wedged PAP (PAWP) >15 mm Hg. A combination of mean PAP and mean PAWP defines postcapillary PH. Postcapillary PH is generally associated with a diastolic pulmonary pressure gradient (diastolic PAP minus mean PAWP) <7 mm Hg, a transpulmonary pressure gradient (mean PAP minus mean PAWP) <12 mm Hg, and pulmonary vascular resistance ≤3 Wood units (WU)...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28902412/interventions-for-treating-tuberculous-pericarditis
#20
REVIEW
Charles S Wiysonge, Mpiko Ntsekhe, Lehana Thabane, Jimmy Volmink, Dumisani Majombozi, Freedom Gumedze, Shaheen Pandie, Bongani M Mayosi
BACKGROUND: Tuberculous pericarditis can impair the heart's function and cause death; long term, it can cause the membrane to fibrose and constrict causing heart failure. In addition to antituberculous chemotherapy, treatments include corticosteroids, drainage, and surgery. OBJECTIVES: To assess the effects of treatments for tuberculous pericarditis. SEARCH METHODS: We searched the Cochrane Infectious Diseases Group Specialized Register (27 March 2017); the Cochrane Central Register of Controlled Trials (CENTRAL), published in the Cochrane Library (2017, Issue 2); MEDLINE (1966 to 27 March 2017); Embase (1974 to 27 March 2017); and LILACS (1982 to 27 March 2017)...
September 13, 2017: Cochrane Database of Systematic Reviews
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