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https://www.readbyqxmd.com/read/29667144/efficacy-and-safety-of-zofenopril-versus-ramipril-in-the-treatment-of-myocardial-infarction-and-heart-failure-a-review-of-the-published-and-unpublished-data-of-the-randomized-double-blind-smile-4-study
#1
REVIEW
Claudio Borghi, Stefano Omboni, Salvatore Novo, Dragos Vinereanu, Giuseppe Ambrosio, Ettore Ambrosioni
Zofenopril is a lipophilic, sulfhydryl group-containing angiotensin-converting enzyme (ACE)-inhibitor, characterized by wide tissue distribution, long duration of action, and pleiotropic effects on endothelial dysfunction. Its clinical efficacy and safety have been described in the four randomized controlled trials of the SMILE program, which globally enrolled more than 3600 patients in post-acute myocardial infarction (AMI) setting. The SMILE-4 study specifically selected patients with left ventricular dysfunction at admission, and compared the effects of zofenopril or ramipril in combination with acetylsalicylic acid (ASA)...
April 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29657594/clinical-and-echocardiographic-response-of-apical-vs-nonapical-right-ventricular-lead-position-in-crt-a-meta-analysis
#2
Sharan Prakash Sharma, Khagendra Dahal, Paari Dominic, Rajbir S Sangha
Background: Traditionally the right ventricular (RV) pacing lead is placed in the RV apex in cardiac resynchronization therapy (CRT). It is not clear whether nonapical placement of the RV lead is associated with a better response to CRT. We aimed to perform a meta-analysis of all randomized controlled trials (RCTs) that compared apical and nonapical RV lead placement in CRT. Methods: We searched PubMed, EMBASE, Cochrane, Scopus, and relevant references for studies and performed meta-analysis using random effects model...
April 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29657035/cardiac-resynchronization-therapy-how-did-consensus-guidelines-from-europe-and-the-united-states-evolve-in-the-last-15-years
#3
Giuseppe Boriani, Matteo Ziacchi, Martina Nesti, Antonella Battista, Filippo Placentino, Vincenzo Livio Malavasi, Igor Diemberger, Luigi Padeletti
Cardiac resynchronization therapy (CRT) was proposed around 20 years ago, and its clinical use rapidly moved from pioneering experiences to randomized controlled trials (RCT). Since 2002 recommendations for CRT have been included in international consensus guidelines that even in an early phase recommended CRT as an effective treatment for improving symptoms, reducing hospitalizations and mortality in well-selected patients with wide QRS, left ventricular dysfunction and moderate to severe heart failure (NYHA classes III-IV), on optimal medical therapy...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29623726/the-effect-of-biological-dmards-on-the-risk-of-congestive-heart-failure-in-rheumatoid-arthritis-a-systematic-review
#4
Milad Baniaamam, Walter J Paulus, Annelies B Blanken, Michael T Nurmohamed
A common cardiovascular manifestation in rheumatoid arthritis (RA) is congestive heart failure (CHF) in which inflammation is considered to play a pivotal role. Although anti-inflammatory therapy such as biological disease-modifying anti-rheumatic drugs (bDMARDs) have the potential of improving the cardiac function and reducing the risk of CHF, the published studies showed contrasting results. This review aims to systematically summarize and analyze literature regarding the effect of bDMARDs on the cardiac function and on the risk of CHF in RA...
April 6, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29622155/lack-of-association-between-heart-failure-and-incident-cancer
#5
Senthil Selvaraj, Deepak L Bhatt, Brian Claggett, Luc Djoussé, Sanjiv J Shah, Jiaying Chen, Tasnim F Imran, Saadia Qazi, Howard D Sesso, J Michael Gaziano, Deborah Schrag
BACKGROUND: Several recent studies have suggested an increased cancer risk among patients with heart failure (HF). However, these studies are constrained by limited size and follow-up, lack of comprehensive data on other health attributes, and adjudicated cancer outcomes. OBJECTIVES: This study sought to determine whether HF is associated with cancer incidence and cancer-specific mortality. METHODS: The study assembled a cohort from the Physicians' Health Studies I and II, 2 randomized controlled trials of aspirin and vitamin supplements conducted from 1982 to 1995 and from 1997 to 2011, respectively, that included annual health evaluations and determination of cancer and HF diagnoses...
April 10, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29619635/the-role-of-arterial-hypertension-in-development-heart-failure-with-preserved-ejection-fraction-just-a-risk-factor-or-something-more
#6
REVIEW
Marijana Tadic, Cesare Cuspidi, Athanasios Frydas, Guido Grassi
Heart failure with preserved ejection fraction (HFpEF) is an entity that still raises many questions. The agreement about definition, pathophysiology, and therapeutic approach is still missing. Arterial hypertension is present in majority of patients with HFpEF, and it is still not clear if it represent a risk factor or "sine qua non" condition for HFpEF development. The underlying mechanisms of hypertension and HFpEF involve the same biohumoral systems: renin-angiotensin-aldosterone, sympathetic nervous system, and oxidative stress...
April 4, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29611171/percutaneous-renal-artery-denervation-in-patients-with-chronic-systolic-heart-failure-a-randomized-controlled-trial
#7
Jun-Qing Gao, Wei Yang, Zong-Jun Liu
B: ACKGROUND: Renal denervation (RDN) is as an effective treatment for heart failure, but its effects on cardiac function of patients with heart failure (HF) are not well documented. Here, the aim was to investigate RDN's effect on patients with chronic systolic HF, by conducting a single-center, prospective, randomized, and controlled study. M: ETHODS: Sixty patients with chronic systolic HF were randomly assigned to the RDN or control groups, receiving percutaneous catheter-based RDN with radiofrequency ablation and drug treatment respectively...
April 3, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29608504/inter-atrial-shunting-a-novel-device-based-therapy-for-patients-with-heart-failure
#8
Brian Kw Yum, William H Frishman
Heart failure patients with either reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF) experience a high mortality rate. The most recent pharmacologic advance for treating patients with HFrEF has been with sacubitril/valsartan. Along with pharmaceutical research, there has been interest in device-based therapies as another treatment approach. One novel interventional device therapy that has shown promise in early tests and trials is the inter-atrial shunt device developed by Corvia Medical Inc...
March 30, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29606104/study-protocol-randomized-controlled-trial-reducing-symptom-burden-in-patients-with-heart-failure-with-preserved-ejection-fraction-using-ubiquinol-and-or-d-ribose
#9
Janet D Pierce, Diane E Mahoney, John B Hiebert, Amanda R Thimmesch, Francisco J Diaz, Carol Smith, Qiuhua Shen, Dinesh Pal Mudaranthakam, Richard L Clancy
BACKGROUND: Heart failure (HF), the leading cause of morbidity and mortality in the US, affects 6.6 million adults with an estimated additional 3 million people by 2030. More than 50% of HF patients have heart failure with preserved left ventricular ejection fraction (HFpEF). These patients have impaired cardiac muscle relaxation and diastolic filling, which investigators have associated with cellular energetic impairment. Patients with HFpEF experience symptoms of: (1) fatigue; (2) shortness of breath; and (3) swelling (edema) of the lower extremities...
April 2, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29601367/design-and-rationale-of-the-cognitive-intervention-to-improve-memory-in-heart-failure-patients-study
#10
Susan J Pressler, Bruno Giordani, Marita Titler, Irmina Gradus-Pizlo, Dean Smith, Susan G Dorsey, Sujuan Gao, Miyeon Jung
BACKGROUND: Memory loss is an independent predictor of mortality among heart failure patients. Twenty-three percent to 50% of heart failure patients have comorbid memory loss, but few interventions are available to treat the memory loss. The aims of this 3-arm randomized controlled trial were to (1) evaluate efficacy of computerized cognitive training intervention using BrainHQ to improve primary outcomes of memory and serum brain-derived neurotrophic factor levels and secondary outcomes of working memory, instrumental activities of daily living, and health-related quality of life among heart failure patients; (2) evaluate incremental cost-effectiveness of BrainHQ; and (3) examine depressive symptoms and genomic moderators of BrainHQ effect...
March 29, 2018: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29601115/long-term-beta-blocker-therapy-after-myocardial-infarction-in-the-reperfusion-era-a-systematic-review
#11
Jenny Hong, Arden R Barry
Beta-blockers are recommended as standard of care for patients who experience a myocardial infarction (MI). However, evidence to support this recommendation is primarily derived from the pre-reperfusion era. In the reperfusion era, short-term (≤30 days) beta-blocker therapy has been demonstrated to reduce recurrent MI and angina, but not mortality. The objective of this review was to evaluate the evidence for long-term (≥1 year) beta-blocker therapy in patients post-MI without left ventricular dysfunction in the reperfusion era...
March 30, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29572084/high-intensity-interval-training-versus-moderate-intensity-continuous-training-on-exercise-capacity-and-quality-of-life-in-patients-with-heart-failure-with-reduced-ejection-fraction-a-systematic-review-and-meta-analysis
#12
Mansueto Gomes Neto, André Rodrigues Durães, Lino Sergio Rocha Conceição, Micheli Bernardone Saquetto, Øyvind Ellingsen, Vitor Oliveira Carvalho
OBJECTIVE: The aim of this study was to investigate the effects of high intensity interval training (HIIT) versus moderate intensity continuous training (MICT) in heart failure patients with reduced ejection fraction (HFrEF). BACKGROUND: Despite the well-known positive effects of exercise in heart failure patients, the best mode of exercise is still under discussion. METHODS: We searched Pubmed/MEDLINE, Cochrane Central Register of Controlled Trials, PEDro data base, and SciELO (from the earliest date available to October 2017) for randomized controlled trials that evaluated the effects of HIIT versus MICT in HFrEF patients...
March 5, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29571623/real-world-evidence-of-superiority-of-endovascular-repair-in-treating-ruptured-abdominal-aortic-aneurysm
#13
Akshay Kumar Gupta, Hanaa Dakour Aridi, Satinderjit Locham, Besma Nejim, Frank J Veith, Mahmoud B Malas
OBJECTIVE: The majority of previous studies, including randomized controlled trials, have failed to provide sufficient evidence of superiority of endovascular aneurysm repair (EVAR) over open aortic repair (OAR) of ruptured abdominal aortic aneurysm (rAAA) while comparing mortality and complications. This is in part due to small study size, patient selection bias, scarce adjustment for essential variables, single insurance type, or selection of only older patients. This study aimed to provide real-world, contemporary, comprehensive, and robust evidence on mortality of EVAR vs OAR of rAAA...
March 20, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29568980/sleep-apnea-in-heart-failure
#14
REVIEW
MuChun Tsai, Rami Khayat
PURPOSE OF REVIEW: In this review, we discuss the current treatment options for sleep-disordered breathing (SDB) in patients with heart failure (HF). We address the role of positive airway pressure (PAP) devices and other emerging therapies. The review includes discussion of recent trials that reported negative consequences for the PAP devices in patients with heart failure. RECENT FINDINGS: Optimal guideline-directed medical therapies of HF and PAP devices have been the mainstay treatments for HF patients with SDB...
March 22, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29564979/levosimendan-for-perioperative-cardioprotection-myth-or-reality
#15
Elpidio Santillo, Monica Migale, Carlo Massini, Raffaele Antonelli Incalzi
BACKGROUND: Levosimendan is a calcium sensitizer drug causing increased contractility in the myocardium and vasodilation in the vascular system. It is mainly used for the therapy of acute decompensated heart failure. Several studies on animals and humans provided evidence of the cardioprotective properties of levosimendan including preconditioning and anti-apoptotic. In view of these favorable effects, levosimendan has been tested in patients undergoing cardiac surgery for the prevention or treatment of low cardiac output syndrome...
March 21, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29557071/current-management-and-future-directions-of-heart-failure-with-preserved-ejection-fraction-a-contemporary-review
#16
REVIEW
Chayakrit Krittanawong, Marrick L Kukin
Heart failure with preserved ejection fraction (HFpEF), a complex and debilitating syndrome, is commonly seen in elderly populations. Exacerbation of HFpEF is among the most common reasons for hospital admission in the USA. The high rate of morbidity and mortality from this condition underscores the fact that HFpEF is heterogeneous, complex, and poorly characterized. Randomized, controlled trials have been very successful at identifying treatments for HF with reduced ejection fraction (HFrEF), but effective treatment options for HFpEF are lacking...
March 20, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29555457/pilot-randomized-controlled-trial-to-reduce-readmission-for-heart-failure-using-novel-tablet-and-nurse-practitioner-education
#17
Khadijah Breathett, Scott Maffett, Randi E Foraker, Rod Sturdivant, Kristina Moon, Ayesha Hasan, Veronica Franco, Sakima Smith, Brent C Lampert, Sitaramesh Emani, Garrie Haas, Rami Kahwash, Ray E Hershberger, Philip F Binkley, Laura Helmkamp, Kathryn Colborn, Pamela N Peterson, Nancy Sweitzer, William T Abraham
BACKGROUND: Heart failure education programs are not standardized. The best form of education is unclear. We evaluated whether addition of a novel tablet application to nurse practitioner (NP) education was superior to NP education alone in reducing 30-day readmission after heart failure hospitalization. METHODS: From 2/2015-3/2016, patients admitted to a quaternary academic center with primary diagnosis of heart failure were randomized to (1) treatment- NP education plus tablet application (interactive conditional logic program that flags patient questions to medical staff) or (2) control- NP education...
March 9, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29552431/editorial-transitional-care-clinics-to-reduce-30-day-readmissions-in-heart-failure-patients
#18
EDITORIAL
Katherine Smith, Jeffrey P Fleming, Bernard Gros
Heart failure (HF) is one of the most prevalent chronic diseases in the United States (U.S.), with an estimated prevalence of five million patients in the U.S. and an annual healthcare cost of greater than 30 billion dollars. Readmission rates for HF patients are astronomically high, with up to 25% of hospitalized patients with HF requiring readmission within 30 days of discharge. The Hospital Readmissions Reduction Program (HRRP) of the Patient Protection and Affordable Care Act aims to address these concerns by financially penalizing institutions with unacceptably high risk-adjusted 30-day readmission rates for HF patients...
January 15, 2018: Curēus
https://www.readbyqxmd.com/read/29549512/catheter-ablation-versus-medical-therapy-for-patients-with-persistent-atrial-fibrillation-a-systematic-review-and-meta-analysis-of-evidence-from-randomized-controlled-trials
#19
Chen Chen, Xinbin Zhou, Min Zhu, Shenjie Chen, Jie Chen, Hongwen Cai, Jin Dai, Xiaoming Xu, Wei Mao
PURPOSE: The superiority of catheter ablation (CA) for persistent (and long-standing persistent) atrial fibrillation (AF) is currently not well defined. We performed a meta-analysis of randomized controlled trials (RCTs) to assess the clinical outcomes of CA compared with medical therapy in persistent AF patients. METHODS: We systematically searched PubMed, EMBASE, the Cochrane Library, and clinicaltrials.gov for RCTs comparing CA with medical therapy in patients with persistent AF...
March 16, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29546692/vitamin-d-supplementation-does-not-prevent-the-testosterone-decline-in-males-with-advanced-heart-failure-the-evita-trial
#20
Armin Zittermann, Jana B Ernst, Sylvana Prokop, Uwe Fuchs, Jens Dreier, Joachim Kuhn, Cornelius Knabbe, Heiner K Berthold, Ioanna Gouni-Berthold, Jan F Gummert, Jochen Börgermann, Stefan Pilz
PURPOSE: Observational studies indicate a positive association between circulating 25-hydroxyvitamin D (25OHD) and testosterone (T) concentrations. Because low 25OHD concentrations and T deficiency are considered to be a generalized phenomenon in patients with advanced heart failure (HF), we aimed to investigate whether vitamin D supplementation has beneficial effects on T indices in these patients. METHODS: In a pre-specified secondary analysis of the EVITA (effect of vitamin D on mortality in heart failure) randomized controlled trial, we analyzed in male subjects with 25OHD concentrations < 75 nmol/L the effect of a daily vitamin D3 supplement of 4000 IU for 3 years (n = 71) vs...
March 15, 2018: European Journal of Nutrition
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