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https://www.readbyqxmd.com/read/28918491/dynamics-of-allosteric-modulation-of%C3%A2-lymphocyte-function-associated-antigen-1-closure-open-switch-unveiling-the-structural-mechanisms-associated-with-outside-in-signaling-activation
#1
Maryam Abdullahi, Fisayo A Olotu, Mahmoud E Soliman
OBJECTIVES: To provide insight into the dynamics of the shape-shifting mechanistic events associated with the opening (activation) of Lymphocyte Function Associated Antigen-1 upon allosteric modulation by an activator, ICAM Binding Enhancer-667 (IBE-667), using molecular dynamics simulation. RESULTS: Various parameters were used to appropriately describe and understand the sequence of events that characterized its activation across the simulation period such as residual distances, TriCα angles; as well as the dihedral angle...
September 16, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28918355/gallium-iii-chelates-of-mixed-phosphonate-carboxylate-triazamacrocyclic-ligands-relevant-to-nuclear-medicine-structural-stability-and-in-vivo-studies
#2
Maria I M Prata, João P André, Zoltán Kovács, Anett I Takács, Gyula Tircsó, Imre Tóth, Carlos F G C Geraldes
Three triaza macrocyclic ligands, H6NOTP (1,4,7-triazacyclononane-N,N',N″-trimethylene phosphonic acid), H4NO2AP (1,4,7-triazacyclononane-N-methylenephosphonic acid-N',N″-dimethylenecarboxylic acid), and H5NOA2P (1,4,7-triazacyclononane-N,N'-bis(methylenephosphonic acid)-N″-methylene carboxylic acid), and their gallium(III) chelates were studied in view of their potential interest as scintigraphic and PET (Positron Emission Tomography) imaging agents. A (1)H, (31)P and (71)Ga multinuclear NMR study gave an insight on the structure, internal dynamics and stability of the chelates in aqueous solution...
September 1, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28918308/appropriateness-of-different-pedagogical-approaches-to-road-safety-education-for-children-with-developmental-coordination-disorder-dcd
#3
C Purcell, A R Romijn
BACKGROUND: In 2016, 29% of pedestrians killed or seriously injured on the roads in Great Britain were under 15 years of age. Children with Developmental Coordination Disorder (DCD), a chronic disorder affecting the acquisition and execution of motor skills, may be more vulnerable at the roadside than typically developing (TD) children. Current methods used to teach road safety are typically knowledge-based and do not necessarily improve behaviour in real traffic situations. Virtual reality road crossing tasks may be a viable alternative...
September 14, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28918125/iodinated-chlorin-p6-copper-complex-induces-anti-proliferative-effect-in-oral-cancer-cells-through-elevation-of-intracellular-reactive-oxygen-species
#4
Paromita Sarbadhikary, Alok Dube
We investigated the anticancer chemotoxicity of previously reported iodinated chlorin p6 copper complex (ICp6-Cu), a novel chlorophyll derivative in which copper is attached to the side chain carboxylate groups via coordination. Human oral carcinoma cells NT8e, 4451 and the non-cancerous keratinocyte HaCaT cells were treated with ICp6-Cu for 48 h in dark and cell viability, proliferation and morphological alterations were examined. ICp6-Cu showed pronounced cytotoxicity in cancer cells with IC50 ∼40 μM, whereas, the viability of HaCaT cells was not affected...
September 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28918093/topological-structure-determination-of-rna-using-small-angle-x-ray-scattering
#5
Yuba R Bhandari, Linxin Fan, Xianyang Fang, George Zaki, Eric A Stahlberg, Wei Jiang, Charles D Schwieters, Jason R Stagno, Yun-Xing Wang
Knowledge of RNA three-dimensional topological structures provides important insight into the relationship between RNA structural components and function. It is often likely that near complete sets of biochemical and biophysical data containing structural restraints are not available but one still wants to obtain knowledge about approximate topological folding of RNA. In this regard, general methods for determining such topological structures with minimum readily available restraints are lacking. Naked RNAs are difficult to crystallize and NMR spectroscopy is generally limited to small RNA fragments...
September 13, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28917897/reduction-of-au-iii-by-a-%C3%AE-cyclodextrin-polymer-in-acid-medium-a-stated-unattainable-reaction
#6
Rudy Martin-Trasanco, Roberto Cao, Hilda Esperanza Esparza-Ponce, Maria Elena Montero-Cabrera, Ramiro Arratia-Pérez
Gold nanoparticles (AuNPs) can be prepared from the reduction of Au(III) with cyclodextrins acting as both, reducing and capping agent. It has been stated that a basic medium (pH=9-12) is a mandatory condition to achieve such reduction. We demonstrated, for the first time, the reduction of Au(III) by a crosslinked β-cyclodextrin-epichlorohydrin polymer (βCDP) in acid medium (pH ∼3). The coordination of Au(III) to the βCD in βCDP polymer required a βCD:[AuCl4](-) ratio of 4:1. The same ratio was necessary to achieve a 50% of the reduction of Au(III) to Au(0) within the first 24h of reaction...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917725/a-computational-approach-for-phenotypic-comparisons-of-cell-populations-in-high-dimensional-cytometry-data
#7
Ludovic Platon, David Pejoski, Guillaume Gautreau, Brice Targat, Roger Le Grand, Anne-Sophie Beignon, Nicolas Tchitchek
BACKGROUND: Cytometry is an experimental technique used to measure molecules expressed by cells at a single cell resolution. Recently, several technological improvements have made possible to increase greatly the number of cell markers that can be simultaneously measured. Many computational methods have been proposed to identify clusters of cells having similar phenotypes. Nevertheless, only a limited number of computational methods exist to compare the phenotypes of the cell clusters identified by different clustering approaches...
September 13, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28917639/protein-oxidation-involved-in-cys-tyr-post-translational-modification
#8
Susan E Hromada, Adam M Hilbrands, Elysa M Wolf, Jackson L Ross, Taylor R Hegg, Andrew G Roth, Matthew T Hollowell, Carolyn E Anderson, David E Benson
Some post-translationally modified tyrosines can perform reversible redox chemistry similar to metal cofactors. The most studied of these tyrosine modifications is the intramolecular thioether-crosslinked 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) in galactose oxidase. This Cu-mediated tyrosine modification in galactose oxidase involves direct electron transfer (inner-sphere) to the coordinated tyrosine. Mammalian cysteine dioxygenase enzymes also contain a Cys-Tyr that is formed, presumably, through outer-sphere electron transfer from a non-heme iron center ~6Å away from the parent residues...
September 14, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28917638/novel-antihelmintic-activity-of-tinidazole-coordination-compounds-relevance-of-the-metal-ion-and-structural-properties
#9
Israel Alfaro-Fuentes, Rodrigo Castro-Ramírez, Naytzé Ortiz-Pastrana, Rosa María Medina-Guerrero, Lilia Catherinne Soler-Jiménez, Irma Martínez-Rodríguez, Miguel Betancourt-Lozano, Leonardo Ibarra-Castro, Norah Barba-Behrens, Emma Josefina Fajer-Ávila
The in vitro and in vivo antihelmintic activity of cobalt(II), copper(II) and zinc(II) coordination compounds of tinidazole (tnz) were investigated in cultivated spotted rose snapper, infested with dactylogyrid monogeneans. The tinidazole coordination compounds [Co(tnz)2Cl2], [Co(tnz)2Br2], [Cu(tnz)2Cl2], [Cu(tnz)2Br2], [Zn(tnz)2Cl2] and [Zn(tnz)2Br2] were synthesized and spectroscopically characterized. Their molecular structures were determined by their single crystal X-ray diffraction. The metal ions presented distorted tetrahedral geometries, with an intramolecular bifurcated lone pair SO⋯π, from the sulfone group with the imidazolic ring, which contributed to the stability of the compounds in solid state and in solution...
August 30, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28917603/development-of-the-nurses-care-coordination-competency-scale-for-mechanically-ventilated-patients-in-critical-care-settings-in-japan-part-1-development-of-a-measuring-instrument
#10
Chie Takiguchi, Yumiko Yatomi, Tomoko Inoue
OBJECTIVES: To develop a draft scale measuring nurses' care coordination competency for care of mechanically ventilated patients in critical care settings. METHOD: The scale items and concepts were derived from semi-structured interviews with 28 professionals (14 nurses, eight physicians, three physical therapists, three clinical engineers) who are managing mechanically ventilated critical care patients. A grounded theory approach was used. After content validation by experts, two pilot tests were used to identify and correct non-discriminating items and vague items...
September 13, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28917539/hemagglutinin-specific-cd4-t-cell-responses-following-2009-ph1n1-inactivated-split-vaccine-inoculation-in-humans
#11
Shuguang Tan, Shihong Zhang, Bin Wu, Yingze Zhao, Wei Zhang, Min Han, Ying Wu, Guoli Shi, Yingxia Liu, Jinghua Yan, Guizhen Wu, Hua Wang, George F Gao, Fengcai Zhu, William J Liu
Influenza A virus remains a major threat to public health, and the inactivated split-virus vaccine is the most prevalent vaccine used worldwide. However, our knowledge about cellular immune responses to the inactivated influenza virus vaccine and its correlation with humoral responses are yet limited, which has restricted our understanding of the vaccine's protective mechanisms. Herein, in two clinical trials, T-cell responses specific for both previously identified human leucocyte antigen (HLA)-I-restricted epitopes from influenza virus and hemagglutinin (HA) protein were longitudinally investigated before, during, and after a two-dose vaccination with the inactivated 2009 pandemic H1N1 (2009-pH1N1) vaccine...
September 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28917335/-a-tool-for-improving-the-transition-between-hospital-and-community-care-for-the-elderly
#12
Julie Giraud, Marie Thevenet, Ratiba Haddad, Isabelle Bruere, Stéphane Leveque, Mathieu Mion, André Rieutord
The hospital-community interface represents a real challenge in the care of elderly people. A lack of coordination and communication is the main obstacle to ensuring the fluidity of this pathway. On a definite territory, a new hospital-community liaison sheet was developed as the result of a collaborative approach and then evaluated. This simple, useful and effective cross-professional tool, is the first step towards improving communication between these two universes.
September 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28917156/tgf%C3%AE-1-synergizes-with-flt3-ligand-to-induce-chemoresistant-quiescence-in-acute-lymphoblastic-leukemia-with-mll-gene-rearrangements
#13
M Tamai, Y Furuichi, S Kasai, N Ando, D Harama, K Goi, T Inukai, K Kagami, M Abe, H Ichikawa, K Sugita
Fms-like tyrosine kinase 3 (FLT3) is highly expressed in mixed-lineage leukemia (MLL) gene-rearranged acute lymphoblastic leukemia (MLL+ALL) with a dismal prognosis. We previously reported that FLT3 ligand (FL) stimulation induced cell cycle arrest in MLL+ALL cells leading to resistance against anti-leukemic agents. Given that FL stimulation enhanced transforming growth factor (TGF)β1 mRNA levels in MLL+ALL cells, we extensively examined the effect of TGFβ1 on the cell cycle progression and chemosensitivity in MLL+ALL cells, and found that TGFβ1 stimulation induced MLL+ALL cells into cell cycle arrest resistant to arabinosyl cytosine; its effect was markedly enhanced in synergy with FL...
September 13, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28917097/development-of-motor-imagery-and-anticipatory-action-planning-in-children-with-developmental-coordination-disorder-a-longitudinal-approach
#14
Imke L J Adams, Jessica M Lust, Peter H Wilson, Bert Steenbergen
Children with impaired motor coordination (or Development Coordination Disorder - DCD) have difficulty with the predictive control of movements, evidenced by cross-sectional studies that show impaired motor imagery and action planning abilities. What remains unclear is whether this deficit in predictive control reflects immaturity of the motor system (a developmental delay) or some deviation from normal development (a disorder). To advance this discussion the present study used a longitudinal design to examine the development of motor imagery and action planning in children with DCD...
September 13, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28916969/comparison-of-platelet-lymphocyte-ratio-and-ca-19-9-in-differentiating-benign-from-malignant-head-masses-in-patients-with-chronic-pancreatitis
#15
Shanavas Kakkat, Ramesh Rajan, R S Sindhu, Bonny Natesh, S Raviram
INTRODUCTION: Pancreatic head ductal adenocarcinoma (PDAC) and inflammatory head masses (IHM) related to chronic pancreatitis are often difficult to differentiate. PDAC produces significant inflammatory response with resultant lymphopenia and thrombocytosis. The prognostic role of platelet-lymphocyte ratio (PLR) as a tumor marker has been defined. We aimed to find the role of PLR as a diagnostic marker for PDAC in differentiating benign head mass comparing with carbohydrate antigen 19-9 (CA 19-9)...
September 16, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28916964/presence-of-a-3fe-4s-cluster-in-a-psac-variant-as-a-functional-component-of-the-photosystem-i-electron-transfer-chain-in-synechococcus-sp-pcc-7002
#16
Adam A Pérez, Bryan H Ferlez, Amanda M Applegate, Karim Walters, Zhihui He, Gaozhong Shen, John H Golbeck, Donald A Bryant
A site-directed C14G mutation was introduced into the stromal PsaC subunit of Synechococcus sp. strain PCC 7002 in vivo in order to introduce an exchangeable coordination site into the terminal FB [4Fe-4S] cluster of Photosystem I (PSI). Using an engineered PSI-less strain (psaAB deletion), psaC was deleted and replaced with recombinant versions controlled by a strong promoter, and the psaAB deletion was complemented. Modified PSI accumulated at lower levels in this strain and supported slower photoautotrophic growth than wild type...
September 15, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28916961/practical-computational-toolkits-for-dendrimers-and-dendrons-structure-design
#17
Nuno Martinho, Liana C Silva, Helena F Florindo, Steve Brocchini, Teresa Barata, Mire Zloh
Dendrimers and dendrons offer an excellent platform for developing novel drug delivery systems and medicines. The rational design and further development of these repetitively branched systems are restricted by difficulties in scalable synthesis and structural determination, which can be overcome by judicious use of molecular modelling and molecular simulations. A major difficulty to utilise in silico studies to design dendrimers lies in the laborious generation of their structures. Current modelling tools utilise automated assembly of simpler dendrimers or the inefficient manual assembly of monomer precursors to generate more complicated dendrimer structures...
September 15, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28916898/a-strengths-based-case-management-intervention-to-reduce-hiv-viral-load-among-people-who-use-drugs
#18
Alex H Kral, Barrot H Lambdin, Megan Comfort, Christina Powers, Helen Cheng, Andrea M Lopez, Robert O Murdoch, Torsten B Neilands, Jennifer Lorvick
Engaging highly marginalized HIV positive people in sustained medical care is vital for optimized health and prevention efforts. Prior studies have found that strengths-based case management helps link people who use drugs to HIV care. We conducted a pilot to assess whether a strengths-based case management intervention may help people who use injection drugs (PWID) or smoke crack cocaine (PWSC) achieve undetectable HIV viral load. PWID and PWSC were recruited in Oakland, California using targeted sampling methods and referral from jails and were tested for HIV...
September 15, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28916885/geometric-analysis-and-clinical-outcome-of-two-cemented-stems-for-primary-total-hip-replacement-with-and-without-modular-necks
#19
Marcel Haversath, Christine Wendelborn, Marcus Jäger, Boris Schmidt, Wojciech Kowalczyk, Stefan Landgraeber
INTRODUCTION: Restoration of the physiological biomechanical principles of the hip is crucial in total hip replacement. The aim of this study was to compare an arthroplasty system with different offset options (a: Exeter(®)) with a dual-modular stem (b: Profemur Xm(®)). MATERIALS AND METHODS: A local and an inertial coordinate system were used to assist the description of the components' assembly in the prosthesis. A resection line of the femoral head in standard position was added to the arthroplasties and geometric parameters were measured...
September 15, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28916788/a-v0-core-neuronal-circuit-for-inspiration
#20
Jinjin Wu, Paolo Capelli, Julien Bouvier, Martyn Goulding, Silvia Arber, Gilles Fortin
Breathing in mammals relies on permanent rhythmic and bilaterally synchronized contractions of inspiratory pump muscles. These motor drives emerge from interactions between critical sets of brainstem neurons whose origins and synaptic ordered organization remain obscure. Here, we show, using a virus-based transsynaptic tracing strategy from the diaphragm muscle in the mouse, that the principal inspiratory premotor neurons share V0 identity with, and are connected by, neurons of the preBötzinger complex that paces inspiration...
September 15, 2017: Nature Communications
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