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Min-Ho Shin, Hyo-Jun Kim, Young-Joo Kim
We proposed an optical simulation model for the quantum dot (QD) nanophosphor based on the mean free path concept to understand precisely the optical performance of optoelectronic devices. A measurement methodology was also developed to get the desired optical characteristics such as the mean free path and absorption spectra for QD nanophosphors which are to be incorporated into the simulation. The simulation results for QD-based white LED and OLED displays show good agreement with the experimental values from the fabricated devices in terms of spectral power distribution, chromaticity coordinate, CCT, and CRI...
February 20, 2017: Optics Express
Pablo Benitez, Milena Nikolic, Juan C Miñano
We investigate a new afocal two freeform mirror design problem in first order optics. The resulting first-order partial differential equations for the freeform two mirror system have an analytic solution with the sole condition that the x-y and x'-y' axes are parallel. Two selected solutions are presented. One of them is semiaplanatic (fulfilling the aplanatic condition only for the x-coordinates), while the other is, to our knowledge, the first example of an aplanatic two-mirror system without rotational symmetry...
February 20, 2017: Optics Express
Achut Giree, Mark Mero, Gunnar Arisholm, Marc J J Vrakking, Federico J Furch
During amplification in a noncollinear optical parametric amplifier the spatial and temporal coordinates of the amplified field are inherently coupled. These couplings or distortions can limit the peak intensity, among other things. In this work, a numerical study of the spatiotemporal distortions in BBO-based noncollinear optical parametric chirped-pulse amplifiers (NOPCPAs) is presented for a wide range of parameters and for different amplification conditions. It is shown that for Gaussian pump beams, gain saturation introduces strong distortions and high conversion efficiency always comes at the price of strong spatiotemporal couplings which drastically reduce the peak intensity even when pulse fronts of the pump and the signal are matched...
February 20, 2017: Optics Express
Junzheng Peng, Yingjie Yu, Dingfu Chen, Hongwei Guo, Jinggang Zhong, Mingyi Chen
Since the cylinder surface is closed and periodic in the azimuthal direction, traditional stitching interferometry cannot be used to yield the 360° form map. This paper describes a full cylinder stitching interferometry based on the first-order approximation of cylindrical coordinate transformation. First, it introduces cylindrical projection, which allows us to determine the overlap region of the cylinder without ambiguity. Second, the relationship between the variations of radial coordinates and the movement errors of the rotational stage is derived from the first-order approximation of cylindrical coordinate transformation...
February 20, 2017: Optics Express
Dan Popescu, Loretta Ichim, Florin Stoican
Floods are natural disasters which cause the most economic damage at the global level. Therefore, flood monitoring and damage estimation are very important for the population, authorities and insurance companies. The paper proposes an original solution, based on a hybrid network and complex image processing, to this problem. As first novelty, a multilevel system, with two components, terrestrial and aerial, was proposed and designed by the authors as support for image acquisition from a delimited region. The terrestrial component contains a Ground Control Station, as a coordinator at distance, which communicates via the internet with more Ground Data Terminals, as a fixed nodes network for data acquisition and communication...
February 23, 2017: Sensors
Kumar Saurav, Valeria Costantino, Vittorio Venturi, Laura Steindler
Marine natural products with antibiotic activity have been a rich source of drug discovery; however, the emergence of antibiotic-resistant bacterial strains has turned attention towards the discovery of alternative innovative strategies to combat pathogens. In many pathogenic bacteria, the expression of virulence factors is under the regulation of quorum sensing (QS). QS inhibitors (QSIs) present a promising alternative or potential synergistic treatment since they disrupt the signaling pathway used for intra- and interspecies coordination of expression of virulence factors...
February 23, 2017: Marine Drugs
Lawrence Nnamdi Obasi, Uchechukwu Susan Oruma, Ibrahim Abdulrazak Al-Swaidan, Ponnadurai Ramasami, Chigozie Julius Ezeorah, Alfred Ezinna Ochonogor
N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide (NBTCS) was synthesized by condensation reaction of 4-chlorobenzenesulphonyl chloride and 2-aminobenzothiazole in acetone under reflux. Neodymium(III) and thallium(III) complexes of the ligand were also synthesized. Both ligand and metal complexes were characterized using UV-Vis, IR, ¹H- and (13)C-NMR spectroscopies, elemental analysis and molar conductance measurement. IR studies revealed that the ligand is tridentate and coordinates to the metal ions through nitrogen and oxygen atoms of the sulphonamide group and nitrogen atom attached to benzothiazole ring...
February 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Lili Zhang, Jin Ke, Yulan Wang, Shuang Yang, Richard J Miron, Yufeng Zhang
The immune response to bone biomaterials plays a critical role during early inflammation and biomaterial-induced osteogenesis. Dendritic cells (DCs) possess a significant impact during immune responses to biomaterials. While conventional strategies to evaluate the osteogenic potential of bone substitute materials focus mainly on osteoblast differentiation. Therefore the present study was to investigate the interactions DCs to porous β-tricalcium phosphate (β-TCP) to investigate whether DCs participate in the material-coordinated osteogenic process...
February 27, 2017: Journal of Biomedical Materials Research. Part A
George A Khoury, James Smadbeck, Chris A Kieslich, Alexandra J Koskosidis, Yannis A Guzman, Phanourios Tamamis, Christodoulos A Floudas
Protein structure refinement is the challenging problem of operating on any protein structure prediction to improve its accuracy with respect to the native structure in a blind fashion. Although many approaches have been developed and tested during the last four CASP experiments, a majority of the methods continue to degrade models rather than improve them. Princeton_TIGRESS (Khoury et al., Proteins, 2014) was developed previously and utilizes separate sampling and selection stages involving Monte Carlo and molecular dynamics simulations and classification using an SVM predictor...
February 27, 2017: Proteins
Davide Ascoli, Janet Maringer, Andy Hacket-Pain, Marco Conedera, Igor Drobyshev, Renzo Motta, Mara Cirolli, Władysław Kantorowicz, Christian Zang, Silvio Schueler, Luc Croisé, Pietro Piussi, Roberta Berretti, Ciprian Palaghianu, Marjana Westergren, Jonathan G A Lageard, Anton Burkart, Regula Gehrig Bichsel, Peter A Thomas, Burkhard Beudert, Rolf Övergaard, Giorgio Vacchiano
Tree masting is one of the most intensively studied ecological processes. It affects nutrient fluxes of trees, regeneration dynamics in forests, animal population densities, and ultimately influences ecosystem services. Despite a large volume of research focused on masting, its evolutionary ecology, spatial and temporal variability and environmental drivers are still matter of debate. Understanding the proximate and ultimate causes of masting at broad spatial and temporal scales will enable us to predict tree reproductive strategies and their response to changing environment...
February 27, 2017: Ecology
Abhisek Mondal, Saumen Datta
Hydrogen bond plays a unique role in governing macromolecular interactions with exquisite specificity. These interactions govern the fundamental biological processes like protein folding, enzymatic catalysis, molecular recognition. Despite extensive research work, till date there is no proper report available about the hydrogen bond's energy surface with respect to its geometric parameters, directly derived from proteins. Herein, we have deciphered the potential energy landscape of hydrogen bond directly from the macromolecular coordinates obtained from Protein Data Bank using quantum mechanical electronic structure calculations...
February 27, 2017: Proteins
Simon Gilbody, Helen Lewis, Joy Adamson, Katie Atherton, Della Bailey, Jacqueline Birtwistle, Katharine Bosanquet, Emily Clare, Jaime Delgadillo, David Ekers, Deborah Foster, Rhian Gabe, Samantha Gascoyne, Lesley Haley, Jahnese Hamilton, Rebecca Hargate, Catherine Hewitt, John Holmes, Ada Keding, Amanda Lilley-Kelly, Shaista Meer, Natasha Mitchell, Karen Overend, Madeline Pasterfield, Jodi Pervin, David A Richards, Karen Spilsbury, Gemma Traviss-Turner, Dominic Trépel, Rebecca Woodhouse, Friederike Ziegler, Dean McMillan
Importance: There is little evidence to guide management of depressive symptoms in older people. Objective: To evaluate whether a collaborative care intervention can reduce depressive symptoms and prevent more severe depression in older people. Design, Setting, and Participants: Randomized clinical trial conducted from May 24, 2011, to November 14, 2014, in 32 primary care centers in the United Kingdom among 705 participants aged 65 years or older with Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) subthreshold depression; participants were followed up for 12 months...
February 21, 2017: JAMA: the Journal of the American Medical Association
Fumio Matsuda, Syohei Kinoshita, Shunsuke Nishino, Atsumi Tomita, Hiroshi Shimizu
Central carbon metabolism is controlled by modulating the protein abundance profiles of enzymes that maintain the essential systems in living organisms. In this study, metabolic adaptation mechanisms in the model organism Saccharomyces cerevisiae were investigated by direct determination of enzyme abundance levels in 30 wild type and mutant strains. We performed a targeted proteome analysis using S. cerevisiae strains that lack genes encoding the enzymes responsible for central carbon metabolism. Our analysis revealed that at least 30% of the observed variations in enzyme abundance levels could be explained by global regulatory mechanisms...
2017: PloS One
Robin Strand, Filip Malmberg, Lars Johansson, Lars Lind, Magnus Sundbom, Håkan Ahlström, Joel Kullberg
PURPOSE: To present and evaluate a whole-body image analysis concept, Imiomics (imaging-omics) and an image registration method that enables Imiomics analyses by deforming all image data to a common coordinate system, so that the information in each voxel can be compared between persons or within a person over time and integrated with non-imaging data. METHODS: The presented image registration method utilizes relative elasticity constraints of different tissue obtained from whole-body water-fat MRI...
2017: PloS One
Gina Ancora, Paola Lago, Elisabetta Garetti, Anna Pirelli, Daniele Merazzi, Luca Pierantoni, Fabrizio Ferrari, Giacomo Faldella
The neurodevelopmental impact of fentanyl given to preterm newborns for pain control is still unknown. The aim of this study was to assess the neurodevelopmental impact of 2 regimens of fentanyl administration by a prospective follow-up evaluation. In our previous multicenter, double-blind, randomized controlled trial, 131 mechanically ventilated newborns (gestational age ≤32 weeks) were randomized to fentanyl (continuous infusion of fentanyl + open label boluses of fentanyl) or placebo (continuous infusion of placebo + open label boluses of fentanyl)...
February 24, 2017: Pain
Larissa Nekhlyudov, Christina Lacchetti, Nancy B Davis, Thomas Q Garvey, David P Goldstein, J Chris Nunnink, Jose I Ruades Ninfea, Andrew L Salner, Talya Salz, Lillian L Siu
Purpose This guideline provides recommendations on the management of adults after head and neck cancer (HNC) treatment, focusing on surveillance and screening for recurrence or second primary cancers, assessment and management of long-term and late effects, health promotion, care coordination, and practice implications. Methods ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. The American Cancer Society (ACS) HNC Survivorship Care Guideline was reviewed for developmental rigor by methodologists...
February 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Cristina Romani, Liana Palermo, Anita MacDonald, Ellie Limback, S Kate Hall, Tarekegn Geberhiwot
OBJECTIVE: Phenylketonuria (PKU) is due to an inability to metabolize the amino acid phenylalanine (Phe), leading to its accumulation in the brain. Phe levels can be controlled following a protein-free diet, but cognitive impairments are still present. A number of questions remain to be answered related to which type of metabolic control is important, the age when it is important, the cognitive functions which are most affected and, the best tests to use to monitor cognitive health. METHOD: We investigated the impact of metabolic control at different ages on cognitive performance in 37 early treated adults with PKU...
March 2017: Neuropsychology
Stefano Canossa, Alessia Bacchi, Claudia Graiff, Paolo Pelagatti, Giovanni Predieri, Andrea Ienco, Gabriele Manca, Carlo Mealli
The aromatic methylene blue cation (MB(+)) shows unprecedented ligand behavior in the X-ray structures of the trigonal-planar (TP) complexes MBMCl2 (M = Cu(I), Ag(I)). The two isostructural compounds were exclusively synthesized by grinding together methylene blue chloride and MCl solids. Only in the case of AuCl did the technique lead to a different, yet isoformular, Au(I) derivative with separated MB(+) and AuCl2(-) counterions and no direct N-Au linkage. While the density functional theory (DFT) molecular modeling failed in reproducing the isolated Cu and Ag complexes, the solid-state program CRYSTAL satisfactorily provided for Cu the correct TP building block associated with a highly compact π stacking of the MB(+) ligands...
February 27, 2017: Inorganic Chemistry
Xian Qin, Xiaowang Liu, Wei Huang, Marco Bettinelli, Xiaogang Liu
The synthesis of lanthanide-activated phosphors is pertinent to many emerging applications, ranging from high-resolution luminescence imaging to next-generation volumetric full-color display. In particular, the optical processes governed by the 4f-5d transitions of divalent and trivalent lanthanides have been the key to enabling precisely tuned color emission. The fundamental importance of lanthanide-activated phosphors for the physical and biomedical sciences has led to rapid development of novel synthetic methodologies and relevant tools that allow for probing the dynamics of energy transfer processes...
February 27, 2017: Chemical Reviews
Tatsuhiko Mukuta, Peter V Simpson, Jamila G Vaughan, Brian W Skelton, Stefano Stagni, Massimiliano Massi, Kazuhide Koike, Osamu Ishitani, Ken Onda
We carried out time-resolved infrared (TR-IR) and emission lifetime measurements on a Re(I) carbonyl complex having an N-heterocyclic carbene ligand, namely, fac-[Re(CO)3(PyImPh)Br], under photochemically reactive (in solution in acetonitrile) and nonreactive (in solution in dichloromethane) conditions to investigate the mechanism of photochemical ligand substitution reactions. The TR-IR measurements revealed that no reaction occurs on a picosecond time scale and the cationic product, namely, fac-[Re(CO)3(PyImPh)(MeCN)](+), is produced on a nanosecond time scale only in solution in acetonitrile, which indicates that the reaction proceeds thermally from the excited state...
February 27, 2017: Inorganic Chemistry
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