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https://www.readbyqxmd.com/read/28441773/overview-of-four-functional-classification-systems-commonly-used-in-cerebral-palsy
#1
REVIEW
Andrea Paulson, Jilda Vargus-Adams
Cerebral palsy (CP) is the most common physical disability in childhood. CP comprises a heterogeneous group of disorders that can result in spasticity, dystonia, muscle contractures, weakness and coordination difficulty that ultimately affects the ability to control movements. Traditionally, CP has been classified using a combination of the motor type and the topographical distribution, as well as subjective severity level. Imprecise terms such as these tell very little about what a person is able to do functionally and can impair clear communication between providers...
April 24, 2017: Children
https://www.readbyqxmd.com/read/28441772/structural-and-biochemical-properties-of-novel-self-cleaving-ribozymes
#2
REVIEW
Ki-Young Lee, Bong-Jin Lee
Fourteen well-defined ribozyme classes have been identified to date, among which nine are site-specific self-cleaving ribozymes. Very recently, small self-cleaving ribozymes have attracted renewed interest in their structure, biochemistry, and biological function since the discovery, during the last three years, of four novel ribozymes, termed twister, twister sister, pistol, and hatchet. In this review, we mainly address the structure, biochemistry, and catalytic mechanism of the novel ribozymes. They are characterized by distinct active site architectures and divergent, but similar, biochemical properties...
April 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28441751/implementation-issues-of-adaptive-energy-detection-in-heterogeneous-wireless-networks
#3
Iker Sobron, Iñaki Eizmendi, Wallace A Martins, Paulo S R Diniz, Juan Luis Ordiales, Manuel Velez
Spectrum sensing (SS) enables the coexistence of non-coordinated heterogeneous wireless systems operating in the same band. Due to its computational simplicity, energy detection (ED) technique has been widespread employed in SS applications; nonetheless, the conventional ED may be unreliable under environmental impairments, justifying the use of ED-based variants. Assessing ED algorithms from theoretical and simulation viewpoints relies on several assumptions and simplifications which, eventually, lead to conclusions that do not necessarily meet the requirements imposed by real propagation environments...
April 23, 2017: Sensors
https://www.readbyqxmd.com/read/28441615/near-infrared-light-stimuli-responsive-synergistic-therapy-nanoplatforms-based-on-the-coordination-of-tellurium-containing-block-polymer-and-cisplatin-for-cancer-treatment
#4
Feng Li, Tianyu Li, Wei Cao, Lu Wang, Huaping Xu
Cisplatin (CDDP) has received worldwide approval for clinical use in the past decades. However, its development in cancer chemotherapy was overshadowed by severe side effects and drug resistance. Herein, we developed a CDDP drug delivery system with high encapsulation efficiency and near-infrared light stimuli-responsive drug release properties based on the coordination of novel tellurium-containing block polymer (PEG-PUTe-PEG) and CDDP. The nanocarriers made from PEG-PUTe-PEG were loaded with CDDP and indocyanine green (ICG) simultaneously...
April 17, 2017: Biomaterials
https://www.readbyqxmd.com/read/28441393/sequence-learning-modulates-neural-responses-and-oscillatory-coupling-in-human-and-monkey-auditory-cortex
#5
Yukiko Kikuchi, Adam Attaheri, Benjamin Wilson, Ariane E Rhone, Kirill V Nourski, Phillip E Gander, Christopher K Kovach, Hiroto Kawasaki, Timothy D Griffiths, Matthew A Howard, Christopher I Petkov
Learning complex ordering relationships between sensory events in a sequence is fundamental for animal perception and human communication. While it is known that rhythmic sensory events can entrain brain oscillations at different frequencies, how learning and prior experience with sequencing relationships affect neocortical oscillations and neuronal responses is poorly understood. We used an implicit sequence learning paradigm (an "artificial grammar") in which humans and monkeys were exposed to sequences of nonsense words with regularities in the ordering relationships between the words...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28441385/preoperative-clinical-pathway-of-breast-cancer-patients-determinants-of-compliance-with-eusoma-quality-indicators
#6
Delphine Héquet, Cyrille Huchon, Sandrine Baffert, Séverine Alran, Fabien Reyal, Thuy Nguyen, Alix Combes, Caroline Trichot, Karine Alves, Hélène Berseneff, Roman Rouzier
BACKGROUND: The European Society of Breast Cancer Specialists (EUSOMA) has defined quality indicators for breast cancer (BC). The aim of this study was to describe the preoperative clinical pathway of breast cancer patients and evaluate the determinants of compliance with EUSOMA quality indicators in the Optisoins01 cohort. METHODS: Optisoins01 is a prospective, multicentric study. Data from operable BC patients were collected, including results from before surgery to 1 year follow-up...
April 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28441289/radiological-nuclear-human-monitoring-tabletop-exercise-recommendations-and-lessons-identified
#7
Vinita Chauhan, Devin Duncan, Ruth C Wilkins
Health Canada is the lead department for coordinating the federal response to a Canadian nuclear emergency event. The framework to manage a radiological consequence is outlined in the Federal Nuclear Emergency Plan (FNEP). In 2014, a full scale exercise (FSX) was held to test the capacity of the federal government to handle a nuclear facility emergency disaster in Canada. The FSX provided a means to demonstrate the integration of various departments and agencies in response to such an event, and although a number of task teams within FNEP were tested, the capacity to monitor humans for exposure post-event was not played out fully...
June 2017: Health Physics
https://www.readbyqxmd.com/read/28441147/can-the-generic-antiretroviral-industry-support-access-to-a-universal-antiretroviral-regimen
#8
Carolyn D Amole, Caroline Middlecote, Vineet R Prabhu, N Kumarasamy
PURPOSE OF REVIEW: The generic antiretroviral (ARV) industry played a critical role in the massive scale-up of HIV treatment in low-income and middle-income countries since 2000. As the global community looks ahead to a universal antiretroviral regimen, this article considers the industry's role in supporting universal access to affordable, simpler, more durable, and tolerable HIV treatment regimens. RECENT FINDINGS: Generic manufacturers made treatment scale-up in low-income and middle-income countries possible through reducing prices, combining molecules from different originator companies to develop optimal fixed-dose combinations, and investing in production capacity to meet escalating demand...
April 24, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28440962/designed-heme-cage-%C3%AE-sheet-miniproteins
#9
Areetha D'Souza, Xiangyang Wu, Edwin Kok Lee Yeow, Surajit Bhattacharjya
The structure and function of naturally occurring proteins are governed by a large number of amino acids (≥100). The design of miniature proteins with desired structures and functions not only substantiates our knowledge about proteins but can also contribute to the development of novel applications. Excellent progress has been made towards the design of helical proteins with diverse functions. However, the development of functional β-sheet proteins remains challenging. Herein, we describe the construction and characterization of four-stranded β-sheet miniproteins made up of about 19 amino acids that bind heme inside a hydrophobic binding pocket or "heme cage" by bis-histidine coordination in an aqueous environment...
April 25, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28440840/professionals-perceptions-of-factors-affecting-implementation-and-continuation-of-a-physical-activity-promotion-programme-in-rehabilitation-a-qualitative-study
#10
Femke Hoekstra, Florentina J Hettinga, Marjolein den Breejen, Marjo Duijf, Lucas H V van der Woude, Rienk Dekker, Cees P van der Schans
OBJECTIVE: To describe professionals' perceptions of factors that facilitate or hamper the implementation and continuation of a physical activity promotion programme in rehabilitation. DESIGN: This study used a qualitative design. METHODS: Semi-structured interviews (n = 22) were conducted with rehabilitation professionals (n = 28) involved in the implementation of a physical activity promotion programme. Two additional interviews were conducted with the programme coordinators (n = 2)...
April 21, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28440829/ruthenium-ii-catalyzed-ortho-c-h-arylation-of-diverse-n-heterocycles-with-aryl-silanes-by-exploiting-solvent-controlled-n-coordination
#11
Pradeep Nareddy, Frank Jordan, Michal Szostak
We report the first method for the direct, regioselective Ru(ii)-catalyzed oxidative arylation of C-H bonds in diverse N-heterocycles with aryl silanes by exploiting solvent-controlled N-coordination. The reaction takes advantage of the attractive features of organosilanes as coupling partners, providing proof of concept for N-directed Ru(ii)-catalyzed C-H arylation. This novel, operationally-simple and versatile protocol utilizes the Ru(ii)/CuF2 reagent system in which CuF2 serves as a dual activator/oxidant in non-coordinating solvents to accommodate for ligand N-coordination...
April 25, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28440796/the-importance-of-international-collaboration-for-rare-diseases-research-a-european-perspective
#12
REVIEW
D Julkowska, C P Austin, C M Cutillo, D Gancberg, C Hager, J Halftermeyer, A H Jonker, L P L Lau, I Norstedt, A Rath, R Schuster, E Simelyte, S van Weely
Over the last two decades, important contributions were made at national, European and international levels to foster collaboration into rare diseases research. The European Union (EU) has put much effort into funding rare diseases research, encouraging national funding organizations to collaborate together in the E-Rare programme, setting up European Reference Networks for rare diseases and complex conditions, and initiating the International Rare Diseases Research Consortium (IRDiRC) together with the National Institutes of Health in the USA...
April 25, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28440634/m-carboranylphosphinate-as-versatile-building-blocks-to-design-all-inorganic-coordination-polymers
#13
Elena Oleshkevich, Clara Viñas, Isabel Romero, Duane Choquesillo-Lazarte, Matti Haukka, Francesc Teixidor
The first examples of coordination polymers of manganese(II) and a nickel(II) complex with a purely inorganic carboranylphosphinate ligand are reported, together with its exhaustive characterization. X-ray analysis revealed 1D polymeric chains with carboranylphosphinate ligands bridging two manganese(II) centers. The reactivity of polymer 1 with water and Lewis bases has also been studied.
April 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28440633/syntheses-structures-and-characterization-of-quaternary-tellurites-li3mte4o11-m-al-ga-and-fe
#14
Minfeng Lü, Hongil Jo, Seung-Jin Oh, Suheon Lee, Kwang-Yong Choi, Yang Yu, Kang Min Ok
Three new quaternary lithium metal tellurites, Li3MTe4O11 (M = Al, Ga, and Fe), have been synthesized through hydrothermal and solid-state reactions by heating a mixture of LiOH·H2O, TeO2, and M2O3. The structures of the title compounds have been determined by single-crystal and powder X-ray diffraction. Li3MTe4O11 reveal three-dimensional (3D) frameworks that consist of MO6 octahedra, TeO3 trigonal pyramids, and TeO4 polyhedra. The variable coordination mode of Te(4+) within the framework leads to the formation of 1D channels that host Li(+) cations on both tetrahedral and octahedral sites...
April 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28440613/constructing-a-heterostructural-lini0-4mn1-6o4-%C3%AE-material-from-concentration-gradient-framework-to-significantly-improve-its-cycling-performance
#15
Fang Lian, Fan Zhang, Lin Yang, Leilei Ma, Yadi Li
A heterostructural LiNi0.35Mn1.65O4-δ-LiNi0.5Mn1.5O4 was achieved via constructing the concentration-gradient material with an average composition of LiNi0.4Mn1.6O4-δ. The as-obtained samples have been characterized by the cross sectional scanning electron microscopy (SEM) and energy dispersive x-ray spectrometry (EDS) that the core material LiNi0.35Mn1.65O4-δ is encapsulated completely by a concentration-gradient shell with the outmost layer of LiNi0.5Mn1.5O4. Demonstrated by high resolution transmission electron microscopy (HRTEM) and X-ray photoelectron spectroscopy (XPS) analysis with low-energy Ar neutral beam etching method, the structurally stable P4332 phase on the surface coordinates the high conductive Fd-3m phase in the bulk without any detectable interface...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28440589/prime-movers-advanced-practice-professionals-in-the-role-of-stroke-coordinator
#16
Nicholas A Rattray, Teresa M Damush, Cherie Luckhurst, Catherine J Bauer-Martinez, Barbara J Homoya, Edward J Miech
BACKGROUND AND PURPOSE: Following a stroke quality improvement clustered randomized trial and a national acute ischemic stroke (AIS) directive in the Veterans Health Administration in 2011, this comparative case study examined the role of advanced practice professionals (APPs) in quality improvement activities among stroke teams. METHODS: Semistructured interviews were conducted at 11 Veterans Affairs medical centers annually over a 3-year period. A multidisciplinary team analyzed interviews from clinical providers through a mixed-methods, data matrix approach linking APPs (nurse practitioners and physician assistants) with Consolidated Framework for Implementation Research constructs and a group organization measure...
April 25, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28440582/phytochrome-interacting-factors-mediate-metabolic-control-of-the-circadian-system-in-arabidopsis
#17
Ekaterina Shor, Inyup Paik, Shlomit Kangisser, Rachel Green, Enamul Huq
The circadian (c. 24 h) system has a central role in regulating the timing and coordination of photosynthesis, and in turn photosynthesis and photosynthetic products which are controlled by the circadian clock feedback to affect the circadian oscillator that generates rhythms. However, little is known about the mechanism(s) by which this feedback occurs. One group of likely candidates for signal transduction to the circadian clock are the PHYTOCHROME INTERACTING FACTOR (PIF) family of transcription factors which have been shown to be involved in numerous signaling pathways in Arabidopsis...
April 25, 2017: New Phytologist
https://www.readbyqxmd.com/read/28440574/a-worldview-of-root-traits-the-influence-of-ancestry-growth-form-climate-and-mycorrhizal-association-on-the-functional-trait-variation-of-fine-root-tissues-in-seed-plants
#18
Oscar J Valverde-Barrantes, Grégoire T Freschet, Catherine Roumet, Christopher B Blackwood
Fine-root traits play key roles in ecosystem processes, but the drivers of fine-root trait diversity remain poorly understood. The plant economic spectrum (PES) hypothesis predicts that leaf and root traits evolved in coordination. Mycorrhizal association type, plant growth form and climate may also affect root traits. However, the extent to which these controls are confounded with phylogenetic structuring remains unclear. Here we compiled information about root and leaf traits for > 600 species. Using phylogenetic relatedness, climatic ranges, growth form and mycorrhizal associations, we quantified the importance of these factors in the global distribution of fine-root traits...
April 25, 2017: New Phytologist
https://www.readbyqxmd.com/read/28440300/insecticide-induced-leg-loss-does-not-eliminate-biting-and-reproduction-in-anopheles-gambiae-mosquitoes
#19
Alison T Isaacs, Amy Lynd, Martin J Donnelly
Recent successes in malaria control have been largely attributable to the deployment of insecticide-based vector control tools such as bed nets and indoor residual spraying. Pyrethroid-treated bed nets are acutely neurotoxic to mosquitoes, inducing symptoms such as loss of coordination, paralysis, and violent spasms. One result of pyrethroid exposure often seen in laboratory tests is mosquito leg loss, a condition that has thus far been assumed to equate to mortality, as females are not expected to blood feed...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28440287/sorption-of-nickel-ii-on-a-calcareous-aridisol-soil-china-batch-xps-and-exafs-spectroscopic-investigations
#20
Shirong Qiang, Bin Han, Xiaolan Zhao, Yunbo Yang, Dadong Shao, Ping Li, Jianjun Liang, Qiaohui Fan
The sorption of Ni(II) on a calcareous aridisol (CA) soil, one of the major soil types in northwestern China, was investigated using batch and extended X-ray absorption fine structure (EXAFS) approaches in a 0.01 mol/L NaClO4 solution at different pH values (6.0-10.0), temperatures (25-60 °C) and contact times (2-15 days). Under alkaline conditions, EXAFS analysis showed that the interatomic distances between Ni and O atoms (RNi-O) were approximately 2.04 Å with a typical coordination number (CN) of ~6...
April 25, 2017: Scientific Reports
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