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Rheumatic heart disease carditis heart failure

Ragab A Mahfouz, Waleed S Alawady, Abdelhakeem Salem
OBJECTIVE: We aimed to investigate the hypothesis that the presence of left ventricular (LV) dyssynchrony in children with acute rheumatic fever (ARF) children may be a predictor of latent rheumatic carditis. METHODS: Eighty-nine children with ARF and 45 healthy control children were included the study. LV dyssynchrony was investigated by color-coded tissue Doppler imaging. RESULTS: LV dyssynchrony parameters including Ts-SD-12, Ts-12, Ts-SD-6, and Ts-6 were found to be prolonged in children with ARF than in controls (P < ...
November 2017: Echocardiography
Taran Kaur Nandra, Nigel J Wilson, John Artrip, Bruno Pagis
Rheumatic heart disease (RHD) has a worldwide prevalence of 33 million cases and 270 000 deaths annually, making it the most common acquired heart disease in the world. There is a disparate global burden in developing countries. This case report aims to address the minimal RHD coverage by the international medical community. A Tahitian boy aged 10 years was diagnosed with advanced heart failure secondary to RHD at a local clinic. Previous, subtle symptoms of changes in handwriting and months of fever had gone unrecognised...
March 10, 2017: BMJ Case Reports
Guilherme S Spina, Roney O Sampaio, Carlos E Branco, George B Miranda, Vitor E E Rosa, Flávio Tarasoutchi
Rheumatic fever (RF) remains endemic in many countries and frequently causes heart failure due to severe chronic rheumatic valvular heart disease, which requires surgical treatment. Here, we report on a patient who underwent an elective surgical correction for mitral and aortic valvular heart disease and had a post-operative diagnosis of acute rheumatic carditis. The incidental finding of Aschoff bodies in myocardial biopsies is frequently reported in the nineteenth-century literature, with prevalences as high as 35%, but no clinical or prognostic data on the patients is included...
2014: Frontiers in Pediatrics
Amanda Chikly, Ronen Durst, Chaim Lotan, Shmuel Chen
Myocarditis consists of an inflammation of the cardiac muscle, definitively diagnosed by endomyocardial biopsy. The causal agents are primarily infectious: in developed countries, viruses appear to be the main cause, whereas in developing countries rheumatic carditis, Chagas disease, and HIV are frequent causes. Furthermore, myocarditis can be indirectly induced by an infectious agent and occurs following a latency period during which antibodies are created. Typically, myocarditis observed in rheumatic fever related to group A streptococcal (GAS) infection occurs after 2- to 3-week period of latency...
2014: Case Reports in Cardiology
Alyaa A Kotby, Ghada S El-Shahed, Ola A Elmasry, Iman S El-Hadidi, Rowaida N S El Shafey
Background. Rheumatic heart disease (RHD) is a leading cause of heart failure in children and young adults worldwide. B-type natriuretic peptide (BNP) is a useful marker of critical pediatric heart disease, and its N-terminal peptide, NT-proBNP, is elevated in congenital and acquired heart disease in children. Aim. To measure NT-proBNP levels as a marker of carditis in children with acute rheumatic carditis, as compared to children with quiescent RHD and healthy controls. Methods. 16 children with acute rheumatic carditis, 33 children with quiescent RHD, and a cohort of 30 healthy children were studied...
2013: ISRN Pediatrics
Mansour Al Qurashi
BACKGROUND: The study was carried out in Riyadh City Hospital to determine the hospital prevalence of acute rheumatic fever (ARF), its characteristics and to determine the proportion of the ARF population that have recurrent attacks. METHODS: The study was an analysis of 83 children with ARF, admitted to the Children's Hospital, Riyadh, over a 10-year period (1994-2003). The diagnosis of ARF was based on clinical features as defined in the modified Jones criteria with evidence of recent streptococcal infection...
October 2009: Journal of the Saudi Heart Association
R Krishna Kumar, R Tandon
Rheumatic fever (RF) and rheumatic heart disease (RHD) continue to be a major health hazard in most developing countries as well as sporadically in developed economies. Despite reservations about the utility, echocardiographic and Doppler (E&D) studies have identified a massive burden of RHD suggesting the inadequacy of the Jones' criteria updated by the American Heart Association in 1992. Subclinical carditis has been recognized by E&D in patients with acute RF without clinical carditis as well as by follow up of RHD patients presenting as isolated chorea or those without clinical evidence of carditis...
April 2013: Indian Journal of Medical Research
Mona Hafez, Sohier Yahia, Waleed Eldars, Heba Eldegla, Mohamed Matter, Gehan Attia, Samia Hawas
Rheumatic heart disease (RHD) is a chronic condition characterized by fibrosis and scarring of the cardiac valves and damage to the heart muscle, leading to congestive heart failure and death. This prospective cohort study was conducted to investigate the possible relation between the levels of serum adhesion molecules and acute rheumatic fever (ARF) carditis, valvular insult severity, and residual valvular lesion after improvement of rheumatic activity. Serum levels of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin were assayed by enzyme-linked immunoassay (ELISA) for 50 children with ARF carditis during activity and after improvement and for 50 healthy children as control subjects...
March 2013: Pediatric Cardiology
K E Kramoh, Y N K N'Goran, E Aké-Traboulsi, K C Konin, B C Boka, D B J Koffi, T M Sow, Y C Mandah, M Kakou-Guikahue
BACKGROUND: Rheumatic fever and acute rheumatic carditis (ARC), though now rare in developed countries, are the main cause of acquired heart disease in children and young adults and remain endemic in developing countries. This study aims to establish the current prevalence of ARC in Ivory Coast. PATIENTS AND METHODS: A cross-sectional retrospective study was performed between January 2000 and December 2009 in the pediatric wards of the three university hospitals in Abidjan and in the Institute of Cardiology of Abidjan...
February 2013: Annales de Cardiologie et D'angéiologie
Sandeep Sagar, Peter P Liu, Leslie T Cooper
Myocarditis is an underdiagnosed cause of acute heart failure, sudden death, and chronic dilated cardiomyopathy. In developed countries, viral infections commonly cause myocarditis; however, in the developing world, rheumatic carditis, Trypanosoma cruzi, and bacterial infections such as diphtheria still contribute to the global burden of the disease. The short-term prognosis of acute myocarditis is usually good, but varies widely by cause. Those patients who initially recover might develop recurrent dilated cardiomyopathy and heart failure, sometimes years later...
February 25, 2012: Lancet
Gesmar V H Herdy, Rafael S Gomes, Anna E A Silva, Leandro S Silva, Vânia G S Lopes
OBJECTIVE: To present the long-term follow-up of children hospitalised for severe rheumatic carditis who were treated with corticosteroids. METHODS: This is a retrospective analysis of the outcome of 242 patients with severe rheumatic carditis after discharge from two public hospitals in Niteroi, Brazil. We followed up 118 patients for 4 years or more, with an average of 7.7 years. They were treated with antibiotics to accomplish bacterial eradication and either intravenous methylprednisolone - 40 cases - or oral prednisone - 78 patients - to treat carditis...
June 2012: Cardiology in the Young
Mehmet Halil Ertug, Gokben Gorsel Yılmaz, Gayaz Akçurin, Fırat Kardelen, Abdullah Kocabas, Saadet Gumuşlu, Sibel Kuloglu Genç
OBJECTIVE: Acute rheumatic fever (ARF) is an endemic disease observed in children of developing countries. The purpose of this study was to test if it was possible to identify myocardial involvement in cases with rheumatic carditis by the measurement of serum cardiac TnT. METHODS: 30 patients diagnosed as ARF underwent echocardiography and their cardiac troponin T (cTnT) serum levels were measured. Patients were divided into group 1: Arthritis alone, group 2: carditis, and group 3 carditis with congestive heart failure (CHF)...
July 2011: Annals of Pediatric Cardiology
Utku Arman Orün, Ozben Ceylan, Meki Bilici, Selmin Karademir, Burhan Ocal, Filiz Senocak, Senem Ozgür, Vehbi Doğan, Osman Yılmaz, Mahmut Keskin
UNLABELLED: The study was carried out in Dr. Sami Ulus Children's Hospital to investigate and to compare the incidence and findings of acute rheumatic fever patients (ARF) seen in the past 30 years. The medical records of 1,115 patients with ARF admitted to Dr. Sami Ulus Children's Hospital Department of Pediatric Cardiology during 1980-2009 were retrospectively analyzed. Twenty-one percent of those patients were admitted between 1980 and 1989, 44.6% between 1990 and 1999, and 34.2% between 2000 and 2009...
February 2012: European Journal of Pediatrics
Patrick O Myers, Cécile Tissot, Jan T Christenson, Mustafa Cikirikcioglu, Yacine Aggoun, Afksendiyos Kalangos
OBJECTIVE: Aortic valve repair has encouraging midterm results in selected patients. However, neither the long-term results of cusp extension nor the durability of different pericardial fixation techniques has been reported. Our goal was to address these issues. METHODS: Seventy-eight children with severe rheumatic aortic regurgitation (mean age 12 ± 3.5 years) underwent aortic valve repair using cusp extension over a 15-year period, with fresh autologous pericardium in 53 (67...
October 2010: Journal of Thoracic and Cardiovascular Surgery
Omer Cimen, Bülent Oran, Derya Cimen, Tamer Baysal, Sevim Karaaslan, Ekrem Unal, Kemal Başarili, Sadik Büyükbaş
BACKGROUND: Acute rheumatic carditis is still an important cause of cardiac failure in developing countries. B-type natriuretic peptides, especially N-terminal segment of its prohormone are now recognised as essential parts of cardiologic evaluation. Increased plasma concentrations of B-type natriuretic peptide and its prohormone are markers of cardiac failure and hypoxia in adults. AIM: To measure the prohormone levels in children with acute rheumatic carditis and to determine whether its concentrations correlate with clinical and laboratory findings...
June 2010: Cardiology in the Young
Pedro Ming Azevedo, Raquel Bauer, Valeria de Falco Caparbo, Clovis Artur Almeida Silva, Eloísa Bonfá, Rosa Maria Rodrigues Pereira
AIMS: To evaluate the IL1RN polymorphism as a possible marker for Rheumatic Fever (RF) susceptibility or disease severity. METHODS: The genotypes of 84 RF patients (Jones criteria) and 84 normal race-matched controls were determined through the analysis of the number of 86-bp tandem repeats in the second intron of IL1RN. The DNA was extracted from peripheral-blood leukocytes and amplified with specific primers. Clinical manifestations of RF were obtained through a standardized questionnaire and an extensive chart review...
January 2010: Cytokine
Andrew C Steer, Joseph Kado, Adam W J Jenney, Michael Batzloff, Lepani Waqatakirewa, E Kim Mulholland, Jonathan R Carapetis
OBJECTIVES: To determine the incidence and clinical features of acute rheumatic fever (ARF) in Fiji, and the clinical features of patients presenting to hospital in Fiji with rheumatic heart disease (RHD). DESIGN AND SETTING: A prospective surveillance study at the Colonial War Memorial Hospital in Suva over a 23-month period from December 2005 to November 2007. MAIN OUTCOME MEASURES: Incidence of ARF; clinical features of ARF and RHD. RESULTS: The average annualised incidence of definite cases of ARF in children aged 5-15 years was 15...
February 2, 2009: Medical Journal of Australia
Vedide Tavli, Abdullah Canbal, Berna Saylan, Türkay Saritaş, Timur Meşe, Füsun Atlihan
BACKGROUND: Acute rheumatic carditis is still a major problem in developing countries. Cardiac troponin-I (cTnI) has been identified as a sensitive and specific marker in the diagnosis of myocarditis in children and adults. METHODS: A prospective study was performed using Doppler echocardiography and cTnI in order to detect myocardial involvement in 26 consecutive patients with acute rheumatic valvular disease. Patients were divided into two groups: group 1, rheumatic fever with carditis (n > 16); group 2, rheumatic fever without carditis (n > 10)...
February 2008: Pediatrics International: Official Journal of the Japan Pediatric Society
Ajit Rayamajhi, Deewakar Sharma, Urmila Shakya
BACKGROUND: Acute rheumatic fever (RF) is a common, preventable health problem in developing countries. Sporadic outbreaks and the prevalence in some indigenous populations have renewed interest in RF in developed countries also. AIMS: To describe the clinical, laboratory and echocardiographic features, outcome and value of echocardiography in detecting valvular disease in RF. METHODS: A prospective, cross-sectional study was conducted over 2 years...
September 2007: Annals of Tropical Paediatrics
T K Mishra, N K Mohanty, S K Mishra, P K Rath
OBJECTIVES: Acute rheumatic fever (ARF) continues to affect millions of children in developing countries. Aim of the present study was to evaluate the role of myocardial dysfunction in the genesis of heart failure in patients with rheumatic carditis. There are limited studies on this subject. METHODS AND RESULTS: In this prospective study, 108 consecutive patients of ARF were evaluated by echocardiography and assay of cardiac troponin I blood levels. The patients were divided into three groups...
April 2007: Journal of the Association of Physicians of India
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