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https://www.readbyqxmd.com/read/29781506/articular-cartilage-protection-in-ctsk-mice-is-associated-with-cellular-and-molecular-changes-in-subchondral-bone-and-cartilage-matrix
#1
Fabiana N Soki, Ryu Yoshida, David N Paglia, Le T Duong, Marc F Hansen, Hicham Drissi
Osteoarthritis (OA) is a degenerative disease and a major cause of chronic disability in aging individuals. Cathepsin K (CatK), encoded by the Ctsk gene, has been implicated in the pathogenesis of pycnodysostosis and osteoporosis. The use of a selective inhibitor of CatK was recently shown to delay OA progression in rabbits. However, the cellular mechanisms underlying these protective effects remain unexplored. We examined articular cartilage maintenance and joint bone remodeling using Ctsk null mice (Ctsk-/- ) which underwent destabilization of the medial meniscus (DMM)...
May 21, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29776956/integrin-%C3%AE-3-inhibition-enhances-the-antitumor-activity-of-alk-inhibitor-in-alk-rearranged-nsclc
#2
Ka-Won Noh, Insuk Sohn, Ji-Young Song, Hyun-Tae Shin, Yu Jin Kim, Kyungsoo Jung, Minjung Sung, Mingi Kim, Sungbin An, Joungho Han, Se-Hoon Lee, Mi-Sook Lee, Yoon-La Choi
BACKGROUND: Anaplastic lymphoma kinase (ALK)-positive cancers are sensitive to small molecule ALK kinase inhibitors, but most cases experience failure following treatment. Hence, additional drug targets and combination therapeutic treatments are needed. We investigated gene expression that is regulated by the expression of ALK and explored its roles in cancer progression and therapeutic implication. PATIENTS AND METHODS: We screened ALK-rearranged non-small cell lung cancer (NSCLC) cases using immunohistochemistry and fluorescence in situ hybridization, and then conducted multiplex gene expression analysis...
May 18, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29749642/a-novel-mechanism-of-the-m1-m2-methionine-adenosyltransferase-switch-mediated-hepatocellular-carcinoma-metastasis
#3
Ruizhi Wang, Yi Jin, Xue-Hua Yao, Wenzhe Fan, Jiang Zhang, Yihai Cao, Jiaping Li
Hepatocellular carcinoma (HCC) manifests as a highly metastatic cancer with extremely poor prognosis. However, mechanisms underlying metastasis of HCC are not fully understood. Here, we showed that switching gene expression from MAT1A to MAT2A (M1-M2 switch) promoted cancer invasion and metastasis. Reversion of the M1-M2 switch repressed, whereas enhancing the M1-M2 switch promoted the ability of HCC cells to metastasize. Moreover, we provided clinical data showing that tipping the balance between MAT1A and MAT2A expression correlated with increased metastasis and inferior recurrence-free survival in HCC patients...
May 10, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29729990/quantitative-proteomics-analysis-of-differentially-expressed-proteins-in-ruptured-and-unruptured-cerebral-aneurysms-by-itraq
#4
Pengjun Jiang, Jun Wu, Xin Chen, Bo Ning, Qingyuan Liu, Zhengsong Li, Maogui Li, Fan Yang, Yong Cao, Rong Wang, Shuo Wang
The underlying pathophysiological mechanisms involved in cerebral aneurysms rupture remain unclear. This study was performed to investigate the differentially expressed proteins between ruptured and unruptured aneurysms using quantitative proteomics. The aneurysmal walls of six ruptured aneurysms and six unruptured aneurysms were collected during the surgical operation. The isobaric tags for relative and absolute quantification (iTRAQ) were used to identify the differentially expressed proteins and western blotting was performed to validate the expression of the proteins of interest...
May 3, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29729708/expression-of-extracellular-matrix-and-adhesion-proteins-in-pelvic-organ-prolapse
#5
Monica Cecati, Alessandra Corradetti, Davide Sartini, Valentina Pozzi, Stefano R Giannubilo, Franca Saccucci, Andrea Ciavattini, Monica Emanuelli
Pelvic organ prolapse (POP) is a common disorder in women. It is characterized by the descent of the vaginal wall with consequent drop of pelvic organs. Pregnancy, labour and childbirth seem to be important events leading to the development of POP, since they are associated with prolonged stretch and mechanical stress of muscles, ligaments and connective tissue supporting pelvic organs. In pubocervical fascia, we explored the expression level of extracellular matrix and adhesion molecules. Tissue samples were obtained from twenty patients with POP who underwent cystocele repair, and from twenty control subjects during hysterectomy surgery...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29728077/neuropilin-1-promotes-the-oncogenic-tenascin-c-integrin-%C3%AE-3-pathway-and-modulates-chemoresistance-in-breast-cancer-cells
#6
Adviti Naik, Aida Al-Yahyaee, Nada Abdullah, Juda-El Sam, Noura Al-Zeheimi, Mahmoud W Yaish, Sirin A Adham
BACKGROUND: Neuropilin-1 (NRP-1), a non-tyrosine kinase glycoprotein receptor, is associated with poor prognosis breast cancer, however transcriptomic changes triggered by NRP-1 overexpression and its association with chemoresistance in breast cancer have not yet been explored. METHODS: BT-474 NRP-1 variant cells were generated by stable overexpression of NRP-1 in the BT-474 breast cancer cell line. RNA sequencing and qRT-PCR were conducted to identify differentially expressed genes...
May 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29675921/clinical-and-molecular-insights-into-glanzmann-s-thrombasthenia-in-china
#7
L Zhou, M Jiang, H Shen, T You, Z Ding, Q Cui, Z Ma, F Yang, Z Xie, H Shi, J Su, L Cao, J Lin, J Yin, L Dai, H Wang, Z Wang, Z Yu, C Ruan, L Xia
Glanzmann's thrombasthenia (GT) is a rare bleeding disorder characterized by spontaneous mucocutaneous bleeding. The disorder is caused by quantitative or qualitative defects in integrin αIIbβ3 (encoded by ITGA2B and ITGB3) on the platelet and is more common in consanguineous populations. However, the prevalence rate and clinical characteristics of GT in nonconsanguineous populations have been unclear. We analyzed 97 patients from 93 families with GT in the Han population in China. This analysis showed lower consanguinity (18...
April 19, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29671256/effects-of-growth-hormone-on-pregnancy-rates-of-patients-with-thin-endometrium
#8
N Cui, A-M Li, Z-Y Luo, Z-M Zhao, Y-M Xu, J Zhang, A-M Yang, L-L Wang, G-M Hao, B-L Gao
PURPOSE: To investigate whether growth hormone (GH) could improve pregnancy rates of patients with thin endometrium by clinical study and laboratory experiments. MATERIALS AND METHODS: Ninety-three patients were randomized to either the GH-received group (40) or the routine exogenous administration of estrogens control group (53) for clinical study. The human endometrial carcinoma cell line RL95-2 was used for testing the role of GH with Western blot and real-time PCR by exposure to various concentrations of GH (0...
April 18, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29658346/association-between-thrombophilia-gene-polymorphisms-and-recurrent-pregnancy-loss-risk-in-the-iranian-population
#9
Razieh Bigdeli, Mohammad Reza Younesi, Erfan Panahnejad, Vahid Asgary, Samaneh Heidarzadeh, Hoda Mazaheri, Samira Louni Aligoudarzi
Miscarriage is the most common complication in pregnancy. Considering the importance of the problem thrombophilia in pregnant women and its association with recurrent pregnancy loss (RPL), analysis of polymorphisms of genes involved in thrombophilia can be useful. We investigated the frequency and association between ten polymorphisms of seven thrombophilia genes and RPL in an Iranian population. This case-control study was conducted on 200 women with recurrent pregnancy loss and also on 200 women with at least one successful pregnancy as the control group...
April 15, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29655803/role-of-msc-derived-galectin-3-in-the-aml-microenvironment
#10
Peter P Ruvolo, Vivian R Ruvolo, Jared K Burks, YiHua Qiu, Rui-Yu Wang, Elizabeth J Shpall, Leonardo Mirandola, Numsen Hail, Zhihong Zeng, Teresa McQueen, Naval Daver, Sean M Post, Maurizio Chiriva-Internati, Steven M Kornblau, Michael Andreeff
In acute myeloid leukemia (AML), high Galectin 3 (LGALS3) expression is associated with poor prognosis. The role of LGALS3 derived from mesenchymal stromal cells (MSC) in the AML microenvironment is unclear; however, we have recently found high LGALS3 expression in MSC derived from AML patients is associated with relapse. In this study, we used reverse phase protein analysis (RPPA) to correlate LGALS3 expression in AML MSC with 119 other proteins including variants of these proteins such as phosphorylated forms or cleaved forms to identify biologically relevant pathways...
April 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29643704/bioinformatic-analysis-of-the-possible-regulative-network-of-mir-30a-e-in-cardiomyocytes-2-days-post-myocardial-infarction
#11
Yiping Wang, Yingqiong Huang, Min Zhang, Xiaoqin Zhang, Xuemei Tang, Yan Kang
Background: Both miR-30a and miR-30e are significantly downregulated in cardiomyocytes (CMs) 2 days (d) post myocardial infarction (MI). This study aimed to identify their possible regulative network in CMs 2d post-MI. Methods: The dysregulated mRNAs in left ventricle tissues 2d post-MI in mice model were retrieved from one previous publication. The verified target genes of miR-30a/e and the predicted targets (upregulated 2d post-MI) were subjected to analysis of the involvement in biological processes according to their enrichment in gene ontology (GO) terms...
March 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29596348/new-gene-markers-for-metabolic-processes-and-homeostasis-in-porcine-buccal-pouch-mucosa-during-cells-long-term-cultivation-a-primary-culture-approach
#12
Marta Dyszkiewicz-Konwińska, Mariusz J Nawrocki, Yan Huang, Artur Bryja, Piotr Celichowski, Maurycy Jankowski, Katarzyna Błochowiak, Katarzyna Mehr, Małgorzata Bruska, Michał Nowicki, Maciej Zabel, Bartosz Kempisty
The oral mucosal tissue is a compound structure composed of morphologically and physiologically different cell types. The morphological modification involves genetically determined lifespan, which may be recognized as the balance between cell survival and apoptosis. Although the biochemical processes and pathways in oral mucosa, with special regards to drug transport, delivery, and metabolism, are well known, the cellular physiological homeostasis in this tissue requires further investigation. The porcine buccal pouch mucosal cells (BPMCs) collected from 20 pubertal crossbred Landrace gilts, were used in this study...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29546619/has-the-time-come-to-include-low-level-laser-photobiomodulation-as-an-adjuvant-therapy-in-the-treatment-of-impaired-endometrial-receptivity
#13
Doaa Abdelmageed El Faham, Mohamed Amr Hussein Elnoury, Mona Ibraheim Morsy, Marwa Abdelmoneim El Shaer, Ghada Mohammed Nour Eldin, Osama Mahmoud Azmy
Low-level laser therapy (LLLT) has been used in photobiomodulation to promote healing, regenerate, and restore tissue function. Women with persistent thin endometrium were assumed to encounter diminished activity in the regenerative and functional capacity of their endometrium. The aim of this study was to examine the ability of LLLT in 635 nm wavelength to enhance the proliferation and gene expression of in vitro cultured endometrial cells. Single (SE) versus multiple exposures (ME) to LLLT were examined in the study groups and compared to controls...
March 15, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29461866/the-prognostic-value-of-combinations-of-genetic-polymorphisms-in-the-itgb3-itga2-and-cyp2c19-2-genes-in-predicting-cardiovascular-outcomes-after-coronary-bypass-grafting
#14
Yuriy I Grinshtein, Aleksandra A Kosinova, Igor Y Grinshtein, Tatyana N Subbotina, Andrey A Savchenko
AIM: To determine if there are any associations between the single nucleotide polymorphisms (SNPs): rs2046934, rs1126643, rs5918, rs6065, rs4244285; rs4986893 and the occurrence of cardiovascular events (CVE) in patients following coronary artery bypass grafting (CABG) surgery. MATERIALS AND METHODS: The study included 130 CABG patients with stable angina grades II-IV. After CABG 69 of the patients were treated with acetylsalicylic acid (ASA) alone, and 61 received dual antiplatelet therapy (ASA+clopidogrel)...
April 2018: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29449539/g9a-promotes-gastric-cancer-metastasis-by-upregulating-itgb3-in-a-set-domain-independent-manner
#15
Lei Hu, Ming-de Zang, He-Xiao Wang, Bao-Gui Zhang, Zhen-Qiang Wang, Zhi-Yuan Fan, Huo Wu, Jian-Fang Li, Li-Ping Su, Min Yan, Zhi-Qiang Zhu, Qiu-Meng Yang, Qiang Huang, Bing-Ya Liu, Zheng-Gang Zhu
Tumor metastasis is the leading cause of death in patients with advanced gastric cancer (GC). Limited therapeutic regimens are available for this condition, which is associated with a poor prognosis, and the mechanisms underlying tumor metastasis remain unclear. In the present study, increased histone methyltransferase G9A expression in GC tissues correlated with advanced stage and shorter overall survival, and in vitro and in vivo experiments revealed that G9A promoted tumor invasion and metastasis. Moreover, we observed that Reg IV induced G9A via the p-ERK/p-SP1 pathway...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29439184/a-novel-variant-glanzmann-thrombasthenia-due-to-co-inheritance-of-a-loss-and-a-gain-of-function-mutation-of-itgb3-evidence-of-a-dominant-effect-of-gain-of-function-mutations
#16
Loredana Bury, Eva Zetterberg, Eva B Leinoe, Emanuela Falcinelli, Alessandro Marturano, Giorgia Manni, Alan T Nurden, Paolo Gresele
No abstract text is available yet for this article.
February 8, 2018: Haematologica
https://www.readbyqxmd.com/read/29434872/regulator-of-g-protein-signaling-5-enhances-portal-vein-invasion-in-hepatocellular-carcinoma
#17
Yumi Umeno, Sachiko Ogasawara, Jun Akiba, Satoshi Hattori, Hironori Kusano, Osamu Nakashima, Hironori Koga, Takuji Torimura, Ryoji Yamakawa, Hirohisa Yano
Portal vein invasion (PVI) is a major prognostic factor in hepatocellular carcinoma (HCC). The aim of the present study was to identify molecules that regulate PVI. Sections of cancerous tissue, paired noncancerous tissue and the PVI area were collected from 3 frozen HCC sections, using laser microdissection. The present study focused on 3 upregulated molecules, integrin β3 (ITGB3), secreted phosphoprotein 1 (SPP1) and regulator of G-protein signaling 5 (RGS5), and 2 molecules that were downregulated in PVI tissue compared with cancer tissue, metallothionein 1G (MT1G) and metallothionein 1H (MT1H), as determined by cDNA microarray analysis...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29385657/in-silico-analysis-of-structural-modifications-in-and-around-the-integrin-%C3%AE-iib-genu-caused-by-itga2b-variants-in-human-platelets-with-emphasis-on-glanzmann-thrombasthenia
#18
Xavier Pillois, Pierre Peters, Karin Segers, Alan T Nurden
BACKGROUND: Studies on the inherited bleeding disorder, Glanzmann thrombasthenia (GT), have helped define the role of the αIIbβ3 integrin in platelet aggregation. Stable bent αIIbβ3 undergoes conformation changes on activation allowing fibrinogen binding and its taking an extended form. The αIIb genu assures the fulcrum of the bent state. Our goal was to determine how structural changes induced by missense mutations in the αIIb genu define GT phenotype. METHODS: Sanger sequencing of ITGA2B and ITGB3 in the index case followed by in silico modeling of all known GT-causing missense mutations extending from the lower part of the β-propeller, and through the thigh and upper calf-1 domains...
March 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29383126/hypoxia-mediated-translational-activation-of-itgb3-in-breast-cancer-cells-enhances-tgf-%C3%AE-signaling-and-malignant-features-in-vitro-and-in-vivo
#19
Marta Sesé, Pedro Fuentes, Anna Esteve-Codina, Eva Béjar, Kimberley McGrail, George Thomas, Trond Aasen, Santiago Ramón Y Cajal
Breast cancer is the most prevalent malignancy in women and there is an urgent need for new therapeutic drugs targeting aggressive and metastatic subtypes, such as hormone-refractory triple-negative breast cancer (TNBC). Control of protein synthesis is vital to cell growth and tumour progression and permits increased resistance to therapy and cellular stress. Hypoxic cancer cells attain invasive and metastatic properties and chemotherapy resistance, but the regulation and role of protein synthesis in this setting is poorly understood...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29380037/a-novel-heterozygous-itgb3-p-t720del-inducing-spontaneous-activation-of-integrin-%C3%AE-iib%C3%AE-3-in-autosomal-dominant-macrothrombocytopenia-with-aggregation-dysfunction
#20
Naohiro Miyashita, Masahiro Onozawa, Koji Hayasaka, Takahiro Yamada, Ohsuke Migita, Kenichiro Hata, Kohei Okada, Hideki Goto, Masao Nakagawa, Daigo Hashimoto, Kaoru Kahata, Takeshi Kondo, Shinji Kunishima, Takanori Teshima
We identified a novel heterozygous ITGB3 p.T720del mutation in a pedigree with macrothrombocytopenia exhibiting aggregation dysfunction. Platelet aggregation induced by ADP and collagen was significantly reduced, while ristocetin aggregation was normal. Integrin αIIbβ3 was partially activated in a resting status, but platelet expression of αIIbβ3 was downregulated. Functional analysis using a cell line showed spontaneous phosphorylation of FAK in αIIb/β3 (p.T720del)-transfected 293T cells in suspension conditions...
April 2018: Annals of Hematology
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