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https://www.readbyqxmd.com/read/27833078/dapper-homolog-1-alpha-suppresses-metastasis-ability-of-gastric-cancer-through-inhibiting-planar-cell-polarity-pathway
#1
Yuegeng Liu, Jingwan Zhang, Weifang Yu, Xiaoming Zhang, Guiqi Wang, Zengren Zhao
Dapper homolog 1 alpha (DACT1α) is a member of DACT family and an important regulator in the planar cell polarity pathway. We aim to clarify its functional role in metastasis ability of gastric cancer. DACT1α was silenced in all gastric cancer cell lines (8/8), but expressed in normal gastric tissue. Ectopic expression of DACT1α in silenced gastric cancer cell lines (AGS, BGC823 and MGC803) by stable transfection significantly suppressed cancer cell spreading (P < 0.05), migration (P < 0.01) and invasion (P < 0...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27765911/integrin-%C3%AE-2%C3%AE-1-inhibits-mst1-kinase-phosphorylation-and-activates-yes-associated-protein-oncogenic-signaling-in-hepatocellular-carcinoma
#2
Kwong-Fai Wong, Angela M Liu, Wanjin Hong, Zhi Xu, John M Luk
The Hippo pathway regulates the down-stream target Yes-associated protein (YAP) to maintain organ homeostasis, which is commonly inactivated in many types of cancers. However, how cell adhesion dysregulates the Hippo pathway activating YAP oncogene in hepatocellular carcinoma (HCC) remains unclear. Our findings demonstrate that α2β1 integrin (but not other β1 integrins) expressed in HCC cells, after binding to collagen extracellular matrix, could inhibit MST1 kinase phosphorylation and activate YAP pro-oncogenic activities...
October 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27759448/toward-optimal-set-of-single-nucleotide-polymorphism-investigation-before-ivf
#3
A V Ivanov, A G Dedul, Y N Fedotov, E V Komlichenko
BACKGROUND: At present, the patient preparation for IVF needs to undergo a series of planned tests, including the genotyping of single nucleotide polymorphism (SNP) alleles of some genes. In former USSR countries, such investigation was not included in overwhelming majority of health insurance programs and paid by patient. In common, there are prerequisites to the study of more than 50 polymorphisms. An important faced task is to determine the optimal panel for SNP genotyping in terms of price/number of SNP...
October 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27301358/cytochrome-p450-1b1-contributes-to-the-development-of-angiotensin-ii-induced-aortic-aneurysm-in-male-apoe-mice
#4
Shyamala Thirunavukkarasu, Nayaab S Khan, Chi Young Song, Hafiz U Ghafoor, David D Brand, Frank J Gonzalez, Kafait U Malik
Cytochrome P450 (CYP) 1B1 is implicated in vascular smooth muscle cell migration, proliferation, and hypertension. We assessed the contribution of CYP1B1 to angiotensin (Ang) II-induced abdominal aortic aneurysm (AAA). Male Apoe(-/-)/Cyp1b1(+/+) and Apoe(-/-)/Cyp1b1(-/-) mice were infused with Ang II or its vehicle for 4 weeks; another group of Apoe(-/-)/Cyp1b1(+/+) mice was coadministered the CYP1B1 inhibitor 2,3',4,5'-tetramethoxystilbene (TMS) every third day for 4 weeks. On day 28 of Ang II infusion, AAAs were analyzed by ultrasound and ex vivo by Vernier calipers, mice were euthanized, and tissues were harvested...
August 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27225591/gene-and-microrna-expression-are-predictive-of-tumor-response-in-rectal-adenocarcinoma-patients-treated-with-preoperative-chemoradiotherapy
#5
Caterina Millino, Isacco Maretto, Beniamina Pacchioni, Maura Digito, Antonino De Paoli, Vincenzo Canzonieri, Edoardo D'Angelo, Marco Agostini, Flavio Rizzolio, Antonio Giordano, Andrea Barina, Senthilkumar Rajendran, Giovanni Esposito, Gerolamo Lanfranchi, Donato Nitti, Salvatore Pucciarelli
Preoperative chemoradiotherapy (pCRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). However, tumor response to pCRT is not uniform, and there are no effective predictive methods. This study investigated whether specific gene and miRNA expression are associated with tumor response to pCRT. Tissue biopsies were obtained from patients before pCRT and resection. Gene and miRNA expression were analyzed using a one-color microarray technique that compares signatures between responders (R) and non-responders (NR), as measured based on tumor regression grade...
May 25, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27186316/mir-128-modulates-hepatocellular-carcinoma-by-inhibition-of-itga2-and-itga5-expression-retraction
#6
(no author information available yet)
[This retracts the article on p. 1564 in vol. 7, PMID: 26550456.].
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27094978/levels-of-human-platelet-derived-soluble-cd40-ligand-depend-on-haplotypes-of-cd40lg-cd40-itga2
#7
Chaker Aloui, Antoine Prigent, Sofiane Tariket, Caroline Sut, Jocelyne Fagan, Fabrice Cognasse, Tahar Chakroun, Olivier Garraud, Sandrine Laradi
Increased circulating soluble CD40 ligand (sCD40L) is commonly associated with inflammatory disorders. We aimed to investigate whether gene polymorphisms in CD40LG, CD40 and ITGA2 are associated with a propensity to secrete sCD40L; thus, we examined this issue at the level of human platelets, the principal source of sCD40L. We performed single polymorphism and haplotype analyses to test for the effect of twelve polymorphisms across the CD40LG, CD40 and ITGA2 genes in blood donors. ITGA2 presented a positive association with rs1126643, with a significant modification in sCD40L secretion (carriers of C allele, P =  0...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27093792/-mathematic-model-for-prediction-of-liver-fibrosis-progression-rate-in-patients-with-chronic-hepatitis-c-based-on-combination-of-genomic-markers
#8
L M Samokhodskaia, E E Starostina, E B Yarovaya, T N Krasnova, N A Mukhin, V A Tkachuk, V A Sadovnichy
AIM OF STUDY: To evaluate clinical significance of different combinations of gene polymorphisms IL-1b, IL-6, IL-10, TNF, HFE, TGF-b, ATR1, N0S3894, CYBA, AGT, MTHFR, FII, FV, FVII, FXIII, ITGA2, ITGB3, FBG, PAI and their prognostic value for prediction of liver fibrosis progression rate in patients with chronic hepatitis C (CHC). SUBJECTS AND METHODS: 118 patients with CHC were divided into "fast" and "slow" (fibrosis rate progression ≥ 0.13 and < 0.13 fibrosis units/yr; n = 64 and n = 54) fibrosis groups...
2015: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
https://www.readbyqxmd.com/read/27067054/dynamics-of-protein-expression-reveals-primary-targets-and-secondary-messengers-of-estrogen-receptor-alpha-signaling-in-mcf-7-breast-cancer-cells
#9
Andrei P Drabovich, Maria P Pavlou, Christina Schiza, Eleftherios P Diamandis
Estrogen receptor alpha (ERα)-mediated proliferation of breast cancer cells is facilitated through expression of multiple primary target genes, products of which induce a secondary response to stimulation. To differentiate between the primary and secondary target proteins of ERα signaling, we measured dynamics of protein expression induced by 17β-estradiol in MCF-7 breast cancer cells. Measurement of the global proteomic effects of estradiol by stable isotope labeling by amino acids in cell culture (SILAC) resulted in identification of 103 estrogen-regulated proteins, with only 40 of the corresponding genes having estrogen response elements...
June 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/26952511/rna-seq-analysis-for-the-potential-targets-and-molecular-mechanisms-of-17-%C3%AE-estradiol-in-squamous-cell-lung-carcinoma
#10
X Chen, R Wu, S Wang, Q Duan, Y Xuan
The efficacy of 17 β-estradiol (E2) was valid in some cancers, while its effects on squamous cell lung carcinoma (SCLC) were still unclear. The aim of our study was to investigate the potential targets and molecular mechanisms of E2 in SCLC cells.Two RNA libraries from human lung carcinoma cells (SK-MES-1) with and without E2 treatment were constructed and sequenced. The differentially expressed genes (DEGs) between cells with or without E2 treatment were identified by cuffdiff software. Hierarchical Clustering Analysis (HCA) was performed for displaying gene expression changes and classification...
2016: Neoplasma
https://www.readbyqxmd.com/read/26893747/identification-of-genes-and-signaling-pathways-associated-with-squamous-cell-carcinoma-by-bioinformatics-analysis
#11
L I Shen, Linbo Liu, Zhenyong Yang, Nan Jiang
The present study aimed to investigate the genes and signaling pathways associated with squamous cell carcinoma (SCC) by bioinformatics analysis. For this purpose, the GSE2503 was downloaded from the Gene Expression Omnibus database, and the differentially expressed genes (DEGs) between 6 normal skin and 5 SCC samples were analyzed using the Linear Models for Microarray Data package. Gene Ontology (GO) and pathway enrichment analysis of DEGs were performed, followed by functional annotation and construction of a protein-protein interaction (PPI) network...
February 2016: Oncology Letters
https://www.readbyqxmd.com/read/26853039/re-regulation-of-the-itga2-gene-by-epigenetic-mechanisms-in-prostate-cancer
#12
Anthony Atala
No abstract text is available yet for this article.
February 2016: Journal of Urology
https://www.readbyqxmd.com/read/26823071/static-mechanical-loading-influences-the-expression-of-extracellular-matrix-and-cell-adhesion-proteins-in-vaginal-cells-derived-from-premenopausal-women-with-severe-pelvic-organ-prolapse
#13
Hala Kufaishi, May Alarab, Harold Drutz, Stephen Lye, Oksana Shynlova
INTRODUCTION: Primary human vaginal cells derived from women with severe pelvic organ prolapse (POP-HVCs) demonstrate altered cellular characteristics as compared to cells derived from asymptomatic women (control-HVCs). Using computer-controllable Flexcell stretch unit, we examined whether POP-HVCs react differently to mechanical loading as compared to control-HVCs by the expression of extracellular matrix (ECM) components, cell-ECM adhesion proteins, and ECM degrading and maturating enzymes...
August 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/26700675/microrna-128-inhibits-emt-of-human-osteosarcoma-cells-by-directly-targeting-integrin-%C3%AE-2
#14
Xinsheng Liu, Zhiyong Liang, Kehai Gao, Huazhuang Li, Guangzong Zhao, Shantao Wang, Jun Fang
Deregulated expression of miRNAs contributes to the development of osteosarcoma. The present study was to evaluate the level of miR-128 and integrin α2 (ITGA2) in osteosarcoma tissues and cells. We further investigated the molecular mechanisms of miR-128 and ITGA2 in osteosarcoma cell lines. In the present study, we found that miR-128 expression was down-regulated in osteosarcoma tissues and MG-63, U2OS, and SAOS-2 cells (all p < 0.001). By contrast, ITGA2 was up-regulated. Furthermore, we found that miR-128 overexpression suppressed cell migration and invasion of MG-63 cells...
June 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26688386/proteome-profiles-of-hdl-particles-of-patients-with-chronic-heart-failure-are-associated-with-immune-response-and-also-include-bacteria-proteins
#15
Andreas Oberbach, Volker Adams, Nadine Schlichting, Marco Heinrich, Yvonne Kullnick, Stefanie Lehmann, Sven Lehmann, Stefan Feder, Joao Carlos Correia, Friedrich-Wilhelm Mohr, Uwe Völker, Nico Jehmlich
Besides modulation of reverse cholesterol transport, high density lipoprotein (HDL) is able to modulate vascular function by stimulating endothelial nitric oxide synthase. Recently, it could be documented that this function of HDL was significantly impaired in patients with chronic heart failure (CHF). We investigated alterations in the HDL proteome in CHF patients. Therefore, HDL was isolated from 5 controls (HDLhealthy) and 5 CHF patients of NYHA-class IIIb (HDLCHF). Proteome analysis of HDL particles was performed by two-dimensional liquid chromatography-mass spectrometry (SCX/RP LC-MS/MS)...
January 30, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/26673451/matrix-metalloproteinase-2-knockout-and-heterozygote-mice-are-protected-from-hydronephrosis-and-kidney-fibrosis-after-unilateral-ureteral-obstruction
#16
Maria K Tveitarås, Trude Skogstrand, Sabine Leh, Frank Helle, Bjarne M Iversen, Christos Chatziantoniou, Rolf K Reed, Michael Hultström
Matrix Metalloproteinase-2 (Mmp2) is a collagenase known to be important in the development of renal fibrosis. In unilateral ureteral obstruction (UUO) the obstructed kidney (OK) develops fibrosis, while the contralateral (CL) does not. In this study we investigated the effect of UUO on gene expression, fibrosis and pelvic remodeling in the kidneys of Mmp2 deficient mice (Mmp2-/-), heterozygous animals (Mmp2+/-) and wild-type mice (Mmp2+/+). Sham operated animals served as controls (Cntrl). UUO was prepared under isoflurane anaesthesia, and the animals were sacrificed after one week...
2015: PloS One
https://www.readbyqxmd.com/read/26556301/platelet-response-to-a-small-molecule-inhibitor-of-%C3%AE-2%C3%AE-1-integrin-is-associated-with-itga2-c807t-dimorphism
#17
Liisa Nissinen, Pekka Rappu, Pauli Ollikka, Jonna Nieminen, Anne Marjamäki, Jyrki Heino
High expression of the collagen receptor, α2β1 integrin, on platelets of ITGA2 807T-allele carriers has been identified as a risk factor for thromboembolic conditions, and α2β1 inhibitors are considered to be potential therapeutic agents. In 59 genotyped individuals, we measured α2 expression levels on platelets and analyzed platelet adhesion to collagen under flow conditions. A sulfonamide-type small-molecule inhibitor of α2β1 integrin decreased average platelet adhesion in individuals with the C/T807T genotype but not in those harboring C807C...
June 2016: Platelets
https://www.readbyqxmd.com/read/26550456/mir-128-modulates-hepatocellular-carcinoma-by-inhibition-of-itga2-and-itga5-expression
#18
Xiaohua Zhao, Yingfen Wu, Zhiping Lv
Dysregulation of miRNAs is a common feature in human cancers, but this phenomenon has not been studied extensively in hepatocellular carcinoma (HCC). miR-128 has been found to be downregulated in cancer. However its role in HCC remains unclear. miR-128 was underexpressed in HCC tissues and cell lines compared with their normal controls. Additionally, ITGA2 and ITGA5 were predicted as the target genes of miR-128. ITGA2 and ITGA5 were inversely correlated with the expression of miR-128 in HCC cells. Importantly, we demonstrate that the overexpression of miR-128 significantly inhibits HCC cell metastasis and stem-cell like properties via ITGA2 and ITGA5...
2015: American Journal of Translational Research
https://www.readbyqxmd.com/read/26515729/polarized-cell-migration-induces-cancer-type-specific-cd133-integrin-src-akt-gsk3%C3%AE-%C3%AE-catenin-signaling-required-for-maintenance-of-cancer-stem-cell-properties
#19
Ying-Jhen Su, Wei-Hsin Lin, Yi-Wen Chang, Kuo-Chen Wei, Chi-Lung Liang, Shin-Cheh Chen, Jia-Lin Lee
CD133 is widely used as a surface marker to isolate cancer stem cells (CSCs). Here we show that in CSCs CD133 contributes to β-catenin-mediated transcriptional activation and to the self-renewal capacity of sphere-forming and side-population (SP) cells in cell lines from brain, colon and lung cancers, but not gastric or breast cancers. In chromatin immunoprecipitation assays, β-catenin binding to the proximal promoter regions of ITGA2-4 and ITGA10-11 in brain, colon and lung cancer cell lines could be triggered by CD133, and β-catenin also bound to the proximal promoter regions of ITGB6 and ITGB8 in cell lines from gastric and breast cancers...
November 10, 2015: Oncotarget
https://www.readbyqxmd.com/read/26464581/patterned-polymer-matrix-promotes-stemness-and-cell-cell-interaction-of-adult-stem-cells
#20
Lucas H Hofmeister, Lino Costa, Daniel A Balikov, Spencer W Crowder, Alexander Terekhov, Hak-Joon Sung, William H Hofmeister
BACKGROUND: The interaction of stem cells with their culture substrates is critical in controlling their fate and function. Declining stemness of adult-derived human mesenchymal stem cells (hMSCs) during in vitro expansion on tissue culture polystyrene (TCPS) severely limits their therapeutic efficacy prior to cell transplantation into damaged tissues. Thus, various formats of natural and synthetic materials have been manipulated in attempts to reproduce in vivo matrix environments in which hMSCs reside...
2015: Journal of Biological Engineering
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