Alerie Guzman de la Fuente, Marie Dittmer, Elise J Heesbeen, Nira de la Vega Gallardo, Jessica A White, Andrew Young, Tiree McColgan, Amy Dashwood, Katie Mayne, Sonia Cabeza-Fernández, John Falconer, Francisco Javier Rodriguez-Baena, Christopher E McMurran, Mohammed Inayatullah, Khalil S Rawji, Robin J M Franklin, James Dooley, Adrian Liston, Rebecca J Ingram, Vijay K Tiwari, Rosana Penalva, Yvonne Dombrowski, Denise C Fitzgerald
Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. Regulatory T cells (Treg) recently emerged as critical players in tissue regeneration, including remyelination. However, the effect of ageing on Treg-mediated regenerative processes is poorly understood. Here, we show that expansion of aged Treg does not rescue age-associated remyelination impairment due to an intrinsically diminished capacity of aged Treg to promote oligodendrocyte differentiation and myelination in male and female mice...
March 11, 2024: Nature Communications