Tianshu Shi, Siyu Shen, Yong Shi, Qianjin Wang, Guanqun Zhang, Jiaquan Lin, Jiang Chen, Feng Bai, Lei Zhang, Yangyufan Wang, Wang Gong, Xiaoyan Shao, Guiquan Chen, Wenjin Yan, Xiang Chen, Yuze Ma, Liming Zheng, Jianghui Qin, Ke Lu, Na Liu, Yun Xu, Yun Stone Shi, Qing Jiang, Baosheng Guo
Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt-β-catenin signalling antagonist, increase with age and inhibit osteoblastogenesis. As Wnt-β-catenin signalling acts as a protective mechanism for memory, we hypothesize that osteocyte-derived sclerostin can impact cognitive function under pathological conditions. Here we show that osteocyte-derived sclerostin can cross the blood-brain barrier of old mice, where it can dysregulate Wnt-β-catenin signalling...
February 26, 2024: Nature metabolism