Siqian Chen, Shuli Liu, Shaolei Shi, Hongwei Yin, Yongjie Tang, Jinning Zhang, Wenlong Li, Gang Liu, Kaixing Qu, Xiangdong Ding, Yachun Wang, Jianfeng Liu, Shengli Zhang, Lingzhao Fang, Ying Yu
The cross-species characterization of evolutionary changes in the functional genome can facilitate the translation of genetic findings across species and the interpretation of the evolutionary basis underlying complex phenotypes. Yet, this has not been fully explored between cattle, sheep, goats, and other mammals. Here, we systematically characterized the evolutionary dynamics of DNA methylation and gene expression in three somatic tissues (i.e., brain, liver, and skeletal muscle) and sperm across seven mammalian species, including three ruminant livestock species (cattle, sheep, and goats), humans, pigs, mice, and dogs, by generating and integrating 160 DNA methylation and transcriptomic datasets...
January 24, 2024: Molecular Biology and Evolution