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vitamin d and copd

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https://www.readbyqxmd.com/read/29731626/the-influence-of-disease-severity-and-lifestyle-factors-on-the-peak-annual-25-oh-d-value-of-copd-patients
#1
Magnus Kentson, Per Leanderson, Petra Jacobson, Hans Lennart Persson
Background: The prevalence of individuals deficient in vitamin D (defined as a serum level of the stable metabolite 25(OH)D <50 nmol/L) is increasing in countries with low annual ultraviolet (UV) radiation and among individuals unable to perform outdoor activities, for example, COPD patients. Objective: To assess the role of vitamin D deficiency, independently of seasonal variation, the peak annual value of 25(OH)D was measured in subjects with advanced COPD ± long-term oxygen therapy (LTOT) and lung healthy control subjects...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29716592/pollution-and-respiratory-disease-can-diet-or-supplements-help-a-review
#2
REVIEW
T Whyand, J R Hurst, M Beckles, M E Caplin
Pollution is known to cause and exacerbate a number of chronic respiratory diseases. The World Health Organisation has placed air pollution as the world's largest environmental health risk factor. There has been recent publicity about the role for diet and anti-oxidants in mitigating the effects of pollution, and this review assesses the evidence for alterations in diet, including vitamin supplementation in abrogating the effects of pollution on asthma and other chronic respiratory diseases. We found evidence to suggest that carotenoids, vitamin D and vitamin E help protect against pollution damage which can trigger asthma, COPD and lung cancer initiation...
May 2, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29709047/vitamin-d-status-of-severe-copd-patients-with-chronic-respiratory-failure
#3
Grzegorz Gawron, Marzena Trzaska-Sobczak, Ewa Sozańska, Piotr Śnieżek, Adam Barczyk
INTRODUCTION: The aim of the study was to measure the concentrations of vitamin D in serum of COPD patients with chronic respiratory failure in comparison to healthy control group. The correlation between the levels of vitamin D in serum and the selected clinical, spirometric and blood gas parameters was the additional aim of the study. MATERIAL AND METHODS: The study included 61 patients with diagnosed COPD in stadium of chronic respiratory failure (45 men and 16 women) and 37 healthy controls (19 men and 18 women)...
2018: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/29691706/low-concentrations-of-25-hydroxyvitamin-d-and-long-term-prognosis-of-copd-a-prospective-cohort-study
#4
Gitte Færk, Yunus Çolak, Shoaib Afzal, Børge G Nordestgaard
Role and importance of vitamin D deficiency in long-term prognosis of chronic obstructive pulmonary disease (COPD) still remains undetermined. We tested the hypothesis that among individuals with COPD, those with low concentrations of 25-hydroxyvitamin D have a poorer prognosis compared to those with normal concentrations. We studied 35,153 individuals from the general population aged 20-100 years with 25-hydroxyvitamin D measurements and spirometry, the Copenhagen City Heart Study [median follow-up 21 years (range 13 days-36 years)] and the Copenhagen General Population Study [7...
April 24, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29652593/vitamin-d-status-in-hospitalized-chronically-ill-patients
#5
Raef Malak Botros, Mona Mohamed AbdElsalam Besibes, Ahmed Mohamed Bahaaeldin, Sherihan Abo Elyazed
OBJECTIVES: Vitamin D deficiency is rarely considered or treated in critically ill patients. Deficiency of 25-hydroxy vitamin D [25(OH)D] prior to hospital admission might be a significant predictor of short- and long-term all cause patient mortality in a critically ill patient. The aim of this work is to investigate the prevalence of vitamin D deficiency in hospitalized patients and its relation to the length of stay and outcome of hospitalization. METHODS: Prospective cohort study performed on 80 patients admitted with acute deterioration of their chronic illness...
April 13, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29600734/inhalation-therapy-for-repairing-damaged-elastin-fibers-and-decelerating-elastinolysis-in-chronic-obstructive-pulmonary-disease
#6
Rob Janssen, Ianthe Piscaer, Emiel Fm Wouters
Current pharmacologic therapy of chronic obstructive pulmonary disease (COPD) can reduce respiratory symptoms and exacerbation frequency. However, no single COPD intervention except for lung transplantation has proven effective in recovering lung function. Lung elasticity is reduced in COPD lungs, which is for a large part due to chronically enhanced elastin degradation. Elastin calcification and formation of advanced glycation end products (AGEs) may also contribute to this. Areas covered: We propose inhalation therapy to induce repair of damaged pulmonary elastin fibers by stimulating tropoelastin synthesis, assembly and crosslinking in order to improve lung function in patients with COPD...
May 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29587583/systematic-review-and-meta-analysis-of-unplanned-reoperations-emergency-department-visits-and-hospital-readmission-after-thyroidectomy
#7
Joseph Margolick, Wenjia Chen, Sam Wiseman
BACKGROUND: Unplanned reoperation, Emergency Department (ED) visits, and hospital readmission following thyroid operations usually arise due to complications, and are a source of frustration for both surgeons and patients. With an aim to provide insight important for the development of patient quality care improvement initiatives, the primary objective of this review was to systematically evaluate the available literature in order to determine the contemporary rates of reoperation, readmission and ED visits following thyroid operations...
March 27, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29564774/serum-vitamin-d-concentration-and-markers-of-bone-metabolism-in-perimenopausal-and-postmenopausal-women-with-asthma-and-copd
#8
K Białek-Gosk, R Rubinsztajn, S Białek, M Paplińska-Goryca, R Krenke, R Chazan
Aging and menopause are closely related to hormonal and metabolic changes. Vitamin D is a crucial factor modulating several metabolic processes. The aim of this study was to evaluate biomarkers of bone metabolism in peri- and postmenopausal women with obstructive lung diseases. Sixty two female patients, 27 with asthma and 35 with COPD, aged over 45 years (median age 58 and 64 years, respectively) were enrolled into the study. The evaluation included lung function, bone mineral density, serum concentration of vitamin D, and bone metabolism markers...
March 22, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29564475/increased-rate-of-osteoporosis-low-lean-mass-and-fragility-fractures-in-copd-patients-association-with-disease-severity
#9
R Q Graumam, M M Pinheiro, L E Nery, C H M Castro
A very high rate of osteoporosis, fractures, and low lean mass was observed in patients with chronic obstructive pulmonary disease (COPD). Disease severity was associated with bone and muscle adverse outcomes, while age ≥ 63.5 years old, low lean mass, higher iPTH, and a T-score below - 2.5 were all associated with higher risk of fracture. INTRODUCTION: Osteoporosis is frequently neglected in patients with COPD. We aimed at evaluating the rate of osteoporosis, fractures, and low lean mass in patients with COPD...
March 21, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29559183/usefulness-of-simple-biomarkers-at-admission-as-independent-indicators-and-predictors-of-in-hospital-mortality-in-older-hip-fracture-patients
#10
Alexander Fisher, Leon Fisher, Wichat Srikusalanukul, Paul N Smith
INTRODUCTION: The data on predictive value of the routinely obtained preoperative biochemical parameters in hip fracture (HF) patients are limited. The aims of this study were to examine in older HF patients (1) the relationships between a broad set of routine laboratory parameters at admission and in-hospital mortality, and (2) evaluate the prognostic value the biomarkers and clinical characteristics (alone or in combination) provide to predict a fatal outcome. PATIENTS AND METHODS: In 1820 consecutive patients with low-trauma osteoporotic HF aged >60 years (mean age 82...
March 8, 2018: Injury
https://www.readbyqxmd.com/read/29520134/obstructive-sleep-apnea-copd-the-overlap-syndrome-and-mortality-results-from-the-2005-2008-national-health-and-nutrition-examination-survey
#11
Wei Du, Jun Liu, Jianlong Zhou, Dan Ye, Yan OuYang, Qingnan Deng
Objective: The aim of this study was to investigate the role of obstructive sleep apnea (OSA) on all-cause mortality in patients with COPD. Methods: Data for this cross-sectional study were obtained from the National Health and Nutrition Examination Survey (NHANES) data (year 2005-2008). Eligible subjects were ≥20 years who had no COPD or OSA (n=9,237), had only OSA (n=366), had only COPD (n=695), and had OSA/COPD overlap syndrome (n=90). Univariate and multivariate analyses were used to evaluate factors associated with overall mortality...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29412517/plasma-proteomic-signatures-in-early-chronic-obstructive-pulmonary-disease
#12
Angela Baralla, Alessandro G Fois, Elisabetta Sotgiu, Elisabetta Zinellu, Arduino A Mangoni, Salvatore Sotgia, Angelo Zinellu, Pietro Pirina, Ciriaco Carru
PURPOSE: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and abnormal inflammatory response of the lungs to inhaled noxious particles or gases. We used a proteomic approach with 2-DE followed by MALDI TOF-MS analyses in order to identify potential biomarkers in the early stages of the disease: global initiative for chronic obstructive pulmonary disease (GOLD) stage mild and moderate. EXPERIMENTAL DESIGN: Blood plasma was collected from 43 patients with mild and moderate COPD as well as from 43 age- and sex-matched control subjects...
February 7, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29362614/effects-of-pleuran-%C3%AE-glucan-from-pleurotus-ostreatus-supplementation-on-incidence-and-duration-of-copd-exacerbations
#13
Jordan Minov, Jovanka Bislimovska-Karadzhinska, Tatjana Petrova, Kristin Vasilevska, Sasho Stoleski, Dragan Mijakoski
BACKGROUND: 1,3/1,6-β-glucans are recognised as immunomodulators in human and veterinary medicine for over 50 years. AIM: To assess the effects of pleuran (1,3/1,6-β-glucan from Pleurotus ostreatus ) on incidence and duration of bacterial exacerbations in patients with COPD. METHODS: We performed an observational, non-randomized, open-label study including 32 COPD patients (Group D) in whom besides the recommended chronic treatment for the stable disease were administered supplement combination containing pleuran 100 mg, vitamin C 60 mg and zinc 5 mg once daily over a three month-period (Group 1)...
December 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29318009/assessment-of-osteoporosis-using-the-frax-method-and-the-importance-of-vitamin-d-levels-in-copd-patients
#14
Ceyda Anar, Melike Yüksel Yavuz, Filiz Güldaval, Yelda Varol, Dilek Kalenci
Background: The aim of this paper was to evaluate the availability of FRAX for assessing osteoporosis risk, and to demonstrate the importance of vitamin D levels in COPD patients. Methods: Fourty-six males who fulfilled the COPD diagnostic criteria defined by GOLD were included. Age, race, BMI, physical activity frequency, smoking and dietary habits, age at COPD diagnosis, disease duration, fractures history, and medications use were determined. Levels of 25(OH)D were detected...
2018: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29243793/a-new-antioxidant-formulation-reduces-the-apoptotic-and-damaging-effect-of-cigarette-smoke-extract-on-human-bronchial-epithelial-cells
#15
L Vanella, G Li Volti, A Distefano, M Raffaele, V Zingales, R Avola, D Tibullo, I Barbagallo
OBJECTIVE: In this study we evaluated the possible protective effect of an antioxidant formulation containing microfiltered milk derived polypeptides, Curcumin, Vitamin B2, Carnitine and N-Acetyl-cysteine (NAC) in an in vitro model of chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: Human bronchial epithelial cells (16HBE) were used in this study. Cells were treated for 24 h in the presence or absence of 10% of cigarette smoke extract (CSE) and in the presence or absence of antioxidant formulation...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29236049/effect-of-monthly-high-dose-long-term-vitamin-d-on-lung-function-a-randomized-controlled-trial
#16
John D Sluyter, Carlos A Camargo, Debbie Waayer, Carlene M M Lawes, Les Toop, Kay-Tee Khaw, Robert Scragg
Although observational studies suggest positive vitamin D-lung function associations, randomized trials are inconsistent. We examined effects of vitamin D supplementation on lung function. We recruited 442 adults (50-84 years, 58% male) into a randomized, double-blinded, placebo-controlled trial. Participants received, for 1.1 years (median; range = 0.9-1.5 years), either (1) vitamin D₃ 200,000 IU, followed by monthly 100,000 IU doses ( n = 226); or (2) placebo monthly ( n = 216). At baseline and follow-up, spirometry yielded forced expiratory volume in 1 s (FEV1; primary outcome)...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29227024/blood-biomarkers-as-predictors-of-long-term-mortality-in-copd
#17
Angelico Mendy, Erick Forno, Theophile Niyonsenga, Janvier Gasana
BACKGROUND: Blood biomarkers are easily accessible and might reflect chronic obstructive pulmonary disease (COPD) activity. AIM: The aim of this study was to determine whether a panel of blood biomarkers [C-reactive protein (CRP), neutrophils, eosinophils, albumin and vitamin D] could predict mortality in COPD. METHODS: We analyzed data from 431 COPD participants to the 2007-2010 National Health and Nutrition Examination Surveys who were followed for a median time of 36 months...
December 11, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29156926/oral-feeding-and-nutritional-improvement-in-hospitals-and-residential-care-homes-industry-innovations
#18
Rosa M Ortega, Ana Isabel Jiménez Ortega, José Miguel Perea Sánchez, Esther Cuadrado Soto, Rosa M Martínez García, Ana M López Sobaler
OBJECTIVES: Inpatient and institutionalized elderly patients are population groups vulnerable from the nutritional point of view because oftheir greater risk of deficiencies and because in them the effects of imbalances are more serious than in other groups. Analyzing the possible usefulness of industry innovations offering solutions in the oral feeding of these population groups constitutes the objective of the present work. METHODS: Bibliographic search related to the topic...
October 15, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29133979/dietary-nutrients-associated-with-preservation-of-lung-function-in-hispanic-and-non-hispanic-white-smokers-from-new-mexico
#19
Shuguang Leng, Maria A Picchi, Yohannes Tesfaigzi, Guodong Wu, W James Gauderman, Fadi Xu, Frank D Gilliland, Steven A Belinsky
Background: COPD is the third leading cause of death in the United States. Cigarette smoking accelerates the age-related forced expiratory volume in 1 s (FEV1 ) decline, an important determinant for the genesis of COPD. Hispanic smokers have lower COPD prevalence and FEV1 decline than non-Hispanic whites (NHWs). Patients and methods: A nutritional epidemiological study was conducted in the Lovelace Smokers cohort (LSC; n=1,829) and the Veterans Smokers cohort (n=508) to identify dietary nutrients (n=139) associated with average FEV1 and its decline and to assess whether nutrient intakes could explain ethnic disparity in FEV1 decline between Hispanics and NHW smokers...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29124703/vitamin-d-cardiovascular-disease-and-risk-factors
#20
REVIEW
Tea Skaaby, Betina H Thuesen, Allan Linneberg
Observational studies have suggested a possible protective role of vitamin D on the cardiovascular system. The available evidence does not support either cardiovascular benefits or harms of vitamin D supplementation. This chapter provides an overview and discussion of the current knowledge of vitamin D effects from a cardiovascular health perspective. It focuses on vitamin D in relation to cardiovascular disease, i.e. ischemic heart disease, and stroke; the traditional cardiovascular risk factors hypertension, abnormal blood lipids, obesity; and the emerging risk factors hyperparathyroidism, microalbuminuria, chronic obstructive pulmonary diseases, and non-alcoholic fatty liver disease...
2017: Advances in Experimental Medicine and Biology
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