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vitamin d and copd

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https://www.readbyqxmd.com/read/28161533/prevalence-determinants-and-clinical-correlates-of-vitamin-d-deficiency-in-patients-with-chronic-obstructive-pulmonary-disease-in-london-uk
#1
David A Jolliffe, Wai Yee James, Richard L Hooper, Neil C Barnes, Claire L Greiller, Kamrul Islam, Angshu Bhowmik, Peter M Timms, Raj K Rajakulasingam, Aklak B Choudhury, David E Simcock, Elina Hyppönen, Robert T Walton, Christopher J Corrigan, Christopher J Griffiths, Adrian R Martineau
Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), yet a comprehensive analysis of environmental and genetic determinants of serum 25-hydroxyvitamin D (25[OH]D) concentration in patients with this condition is lacking. We conducted a multi-centre cross-sectional study in 278 COPD patients aged 41-92 years in London, UK. Details of potential environmental determinants of vitamin D status and COPD symptom control and severity were collected by questionnaire, and blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction...
February 1, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28143855/-nutraceuticals-in-relation-to-human-skeletal-muscle-and-exercise
#2
Colleen Siobhan Deane, Daniel J Wilkinson, Bethan E Phillips, Kenneth Smith, Timothy Etheridge, Philip J Atherton
Skeletal muscles have a fundamental role in locomotion and whole body metabolism, with muscle mass and quality being linked to improved health and even lifespan. Optimising nutrition in combination with exercise is considered an established, effective ergogenic practice for athletic performance. Importantly, exercise and nutritional approaches also remain arguably the most effective countermeasure for muscle dysfunction associated with ageing and numerous clinical conditions e.g. cancer cachexia, COPD and organ failure, via engendering favourable adaptations such as increased muscle mass and oxidative capacity...
January 31, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28024128/-pathogenesis-diagnosis-and-treatment-of-chronic-obstructive-pulmonary-disease-in-the-light-of-new-research
#3
EDITORIAL
Tadeusz Płusa
Accurate number of patients with chronic obtructive pulmonary disease (COPD) is difficult to determine, both in Poland and in the world. Quoted estimates and fragmented with the research indicate that approx. 10% of the world's population may be burdened by this disease. As it turns out, COPD is recognized in 25-45% in non-smokers, suggesting a genetic link. This is confirmed by new data that indicates that further embodiments having genetic polymorphisms associated with the occurrence of the disease. It was further found that the allele GC-1F vitamin D were risk factor for development of COPD...
December 22, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27994981/one-year-mortality-after-severe-copd-exacerbation-in-bulgaria
#4
Evgeni Mekov, Yanina Slavova, Adelina Tsakova, Marianka P Genova, Dimitar T Kostadinov, Delcho Minchev, Dora Marinova, Mihail A Boyanov
INTRODUCTION: One-year mortality in COPD patients is reported to be between 4% and 43%, depending on the group examined. AIM: To examine the one-year mortality in COPD patients after severe exacerbation and the correlation between mortality and patients' characteristics and comorbidities. METHODS: A total of 152 COPD patients hospitalized for severe exacerbation were assessed for vitamin D status, diabetes mellitus (DM), arterial hypertension (AH), and metabolic syndrome (MS)...
2016: PeerJ
https://www.readbyqxmd.com/read/27925404/vitamin-d-deficiency-what-does-it-mean-for-chronic-obstructive-pulmonary-disease-copd-a-concise-review-for-pulmonologists
#5
REVIEW
Kokturk Nurdan, Baha Ayse, Oh Yeon-Mok, Jung Young Ju, Jones W Paul
No abstract text is available yet for this article.
December 7, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27864635/soluble-cd200-correlates-with-interleukin-6-levels-in-sera-of-copd-patients-potential-implication-of-the-cd200-cd200r-axis-in-the-disease-course
#6
Priya Sakthivel, Angele Breithaupt, Marcus Gereke, David A Copland, Christian Schulz, Achim D Gruber, Andrew D Dick, Jens Schreiber, Dunja Bruder
BACKGROUND: COPD represents a multifactorial lung disorder with high morbidity and mortality. Despite intensive research concerning the underlying disease mechanisms, the involvement of the CD200/CD200R axis in supporting or preventing the onset of COPD has not yet been addressed. Since the CD200/CD200R axis is crucially implicated in the maintenance of pulmonary immune homeostasis, we hypothesized that it might be involved in controlling the onset of COPD. METHODS: To address this, we analyzed the serum samples from COPD patients and normal controls for soluble (s) CD200 and correlated the data to COPD-relevant clinical parameters...
November 18, 2016: Lung
https://www.readbyqxmd.com/read/27812429/risk-and-clinical-predictors-of-osteoporotic-fracture-in-east-asian-patients-with-chronic-obstructive-pulmonary-disease-a-population-based-cohort-study
#7
Ping-Hsueh Lee, Victor C Kok, Po-Liang Chou, Ming-Chang Ku, Yu-Ching Chen, Jorng-Tzong Horng
INTRODUCTION: Osteoporosis is becoming an impending epidemic in the Asia-Pacific region. The association between risk of osteoporotic fracture (OTPF) and chronic obstructive pulmonary disease (COPD) in East Asian patients is yet to be fully examined. We conducted a nationwide population-based retrospective cohort study of 98,700 patients aged ≥50 years with or without COPD using a national administrative claims dataset. MATERIALS AND METHODS: The patients were divided into COPD and comparison groups comprising 19,740 and 78,960 patients, respectively...
2016: PeerJ
https://www.readbyqxmd.com/read/27799758/the-association-between-vitamin-d-and-copd-risk-severity-and-exacerbation-an-updated-systematic-review-and-meta-analysis
#8
Min Zhu, Ting Wang, Chengdi Wang, Yulin Ji
BACKGROUND: In recent years, the pleiotropic roles of vitamin D have been highlighted in various diseases. However, the association between serum vitamin D and COPD is not well studied. This updated systematic review and meta-analysis aimed to assess the relationship between vitamin D and the risk, severity, and exacerbation of COPD. METHODS: A systematic literature search was conducted in PubMed, Medline, EMBASE, Chinese National Knowledge Infrastructure, Wanfang, and Weipu databases...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27730178/effect-of-add-on-interventions-on-exercise-training-in-individuals-with-copd-a-systematic-review
#9
Carlos A Camillo, Christian R Osadnik, Hans van Remoortel, Chris Burtin, Wim Janssens, Thierry Troosters
The aim of this review was to identify the effectiveness of therapies added on to conventional exercise training to maximise exercise capacity in patients with chronic obstructive pulmonary disease (COPD). Electronic databases were searched, identifying trials comparing exercise training with exercise training plus "add-on" therapy. Outcomes included peak oxygen uptake (V'O2peak), work rate and incremental/endurance cycle and field walking tests. Individual trial effects on exercise capacity were extracted and collated into eight subgroups and pooled for meta-analysis...
January 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27701486/relationship-between-vitamin-d-and-the-development-of-atrial-fibrillation-after-on-pump-coronary-artery-bypass-graft-surgery
#10
Levent Cerit, Hatice Kemal, Kamil Gulsen, Barcin Ozcem, Zeynep Cerit, Hamza Duygu
BACKGROUND: Vitamin D deficiency is associated with many diverse cardiovascular disorders, such as hypertension, heart failure, stroke, coronary artery disease and atrial fibrillation. The relationship between Vitamin D and the development of atrial fibrillation after coronary artery bypass surgery (CABG) has not been studied. Therefore, we assessed the relationship between Vitamin D and the development of postoperative atrial fibrillation (POAF) after CABG. METHODS: Medical records of consecutive patients who underwent CABG surgery were retrospectively reviewed for the development of atrial fibrillation in the postoperative period...
August 2, 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27655266/vitamin-d-and-allergic-airway-disease-shape-the-murine-lung-microbiome-in-a-sex-specific-manner
#11
Michael Roggenbuck, Denise Anderson, Kenneth Klingenberg Barfod, Martin Feelisch, Sian Geldenhuys, Søren J Sørensen, Clare E Weeden, Prue H Hart, Shelley Gorman
BACKGROUND: Vitamin D is under scrutiny as a potential regulator of the development of respiratory diseases characterised by chronic lung inflammation, including asthma and chronic obstructive pulmonary disease. It has anti-inflammatory effects; however, knowledge around the relationship between dietary vitamin D, inflammation and the microbiome in the lungs is limited. In our previous studies, we observed more inflammatory cells in the bronchoalveolar lavage fluid and increased bacterial load in the lungs of vitamin D-deficient male mice with allergic airway disease, suggesting that vitamin D might modulate the lung microbiome...
2016: Respiratory Research
https://www.readbyqxmd.com/read/27570748/the-effect-of-vitamin-d-on-copd-exacerbation-a-double-blind-randomized-placebo-controlled-parallel-clinical-trial
#12
Mojgan Sanjari, Akbar Soltani, Abdolrahim Habibi Khorasani, Maryam Zareinejad
BACKGROUND: To investigate the effect of supplementation of standard treatment (inhaled long-acting β2 agonists, anticholinergics and corticosteroids) with vitamin D on C reactive protein and pulmonary function tests in patients with COPD exacerbation. METHODS: HASH(0x4868400) DESIGN: Randomized, single-center, double-blind, placebo-controlled parallel trial. One teaching hospital Participants: 135 patients in pulmonary ward with moderate to severe COPD and exacerbations...
2015: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/27461504/-copd-and-bone
#13
Ryo Okazaki
Chronic obstructive pulmonary disease(COPD)is a chronic inflammatory airway disease associated with various systemic comorbidities including osteoporosis. Osteoporosis is extremely common in COPD patients;up to 80%prevalence of vertebral fracture has been reported. However, its low awareness has left many patients untreated. Although pathophysiology of COPD-associated osteoporosis is largely unknown, multiple risk factors for osteoporosis are present, such as smoking, low body weight, systemic inflammation, vitamin D insufficiency, hypoxia...
August 2016: Clinical Calcium
https://www.readbyqxmd.com/read/27424501/the-immunobiological-and-clinical-role-of-vitamin-d-in-obstructive-lung-diseases
#14
Paolo Solidoro, Michela Bellocchia, Fabrizio Facchini
Vitamin D is a fat-soluble vitamin, which is obtained by conversion of 7-dehydrocholesterol in the skin by UV ray and by diet. Its role on bone mineralization has been known for over two hundred years, while its non-skeletal effects have been acknowledged only in the last few years. The discovery of important vitamin D properties on the innate and adaptive immune system created a lot of interest in a potential role of vitamin D on diseases characterized by heightened inflammation and oxidative response, and impaired antimicrobial response, such as asthma and chronic obstructive pulmonary disease (COPD)...
June 2016: Minerva Medica
https://www.readbyqxmd.com/read/27382272/vitamin-d-should-be-supplemented-more-actively-in-elderly-patients-with-coronary-heart-disease-combined-with-copd
#15
Ling Zhang, Qiao-Ying Yuan
OBJECTIVE: It is not clear whether vitamin D should be actively supplemented in elderly patients suffering from an acute attack of COPD (AECOPD) and coronary heart disease (CHD). PATIENTS AND METHODS: The patients were divided into three groups according to specific criteria: patients with AECOPD (group A), patients with COPD combined with CHD (group B), and patients with CHD (group C). We measured the levels of vitamin D and analyzed the correlation between vitamin D and important electrolytes, including prealbumin, creatinine, hemoglobin, cystatin C, blood fat, blood calcium, and blood magnesium, and the nutrition state of the whole body...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27308869/the-immunobiological-and-clinical-role-of-vitamin-d-in-obstructive-lung-diseases
#16
Paolo Solidoro, Michela Bellocchia, Fabrizio Facchini
Vitamin D is a fat-soluble vitamin, which is obtained by conversion of 7-dehydrocholesterol in the skin by UV ray and by diet. Its role on bone mineralization has been known for over two hundred years, while its non-skeletal effects have been acknowledged only in the last few years. The discovery of important vitamin D properties on the innate and adaptive immune system created a lot of interest in a potential role of vitamin D on diseases characterized by heightened inflammation and oxidative response, and impaired antimicrobial response, such as asthma and chronic obstructive pulmonary disease (COPD)...
June 15, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27254950/-nutrition-management-for-copd
#17
REVIEW
Keisuke Miki, Ryoji Maekura
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory reaction of the lung and of the whole body, and pulmonary cachexia often occurs during the advanced stage. The effects of nutritional support upon the management of under-nutrition in COPD remain controversial. However, a study of the effects of nutritional supplement therapy upon such patients with COPD has recently been published. The present report comprises a review of recent articles about the nutritional support of patients with COPD, especially those with cachexia, and a discussion about the roles of nutritional supplement therapy, focusing on exercise and treatment with ghrelin and vitamin D in the management of COPD...
May 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27143867/evidence-of-functional-declining-and-global-comorbidity-measured-at-baseline-proved-to-be-the-strongest-predictors-for-long-term-death-in-elderly-community-residents-aged-85-years-a-5-year-follow-up-evaluation-the-octabaix-study
#18
Francesc Formiga, Assumpta Ferrer, Gloria Padros, Abelardo Montero, Carme Gimenez-Argente, Xavier Corbella
OBJECTIVE: To investigate the predictive value of functional impairment, chronic conditions, and laboratory biomarkers of aging for predicting 5-year mortality in the elderly aged 85 years. METHODS: Predictive value for mortality of different geriatric assessments carried out during the OCTABAIX study was evaluated after 5 years of follow-up in 328 subjects aged 85 years. Measurements included assessment of functional status comorbidity, along with laboratory tests on vitamin D, cholesterol, CD4/CD8 ratio, hemoglobin, and serum thyrotropin...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27105006/vitamin-d-deficiency-is-associated-with-rapid-decline-in-exercise-capacity-in-male-patients-with-chronic-obstructive-pulmonary-disease
#19
Changhwan Kim, Ji Ye Jung, Young Sam Kim, Jae Seung Lee, Chin Kook Rhee, Jin Hwa Lee, Ji-Hyun Lee, Tae-Hyung Kim, Seong Yong Lim, Seung Soo Sheen, Kwang Ha Yoo, Joon Beom Seo, Yeon-Mok Oh, Sang-Do Lee, Yong Bum Park
BACKGROUND: Vitamin D is suggested to play a role in airway and systemic inflammation in chronic obstructive pulmonary disease (COPD). Low serum 25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with lower lung function and poorer exercise capacity in COPD. OBJECTIVES: The main purpose of this study was to investigate the effects of vitamin D deficiency on the change in exercise capacity in male COPD patients. METHODS: A total of 156 male subjects were selected from the Korean Obstructive Lung Disease cohort...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27103796/relationship-between-vitamin-d-binding-protein-polymorphisms-and-blood-vitamin-d-level-in-korean-patients-with-copd
#20
Youngmok Park, Young Sam Kim, Young Ae Kang, Ju Hye Shin, Yeon Mok Oh, Joon Beom Seo, Ji Ye Jung, Sang Do Lee
BACKGROUND: In chronic obstructive pulmonary disease (COPD), the blood vitamin D3 level is generally low, and genetic polymorphisms of vitamin D-binding protein encoded by the GC gene are associated with COPD development. In this study, we examined the relationship between GC polymorphisms and plasma vitamin D3 level in Korean patients with COPD. METHODS: The study included 175 COPD patients from the Korean Obstructive Lung Disease Cohort. Multivariate analysis was conducted with adjustment for age, body mass index (BMI), lung function, smoking status, smoking amount, and seasonal variation in blood vitamin D level...
2016: International Journal of Chronic Obstructive Pulmonary Disease
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