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https://www.readbyqxmd.com/read/28422847/correlation-between-calpain-10-single-nucleotide-polymorphisms-and-obstructive-sleep-apnea-hypopnoea-syndrome-with-ischemic-stroke-in-a-chinese-population-a-population-based-study
#1
Wei Zhang, Zhi-Ru Zhao, Chang-Fei Dai, Rong Zhang, Jie Chen, Hui-Juan Tian, Yun-Long Wang, Ji-Hong Sun, Qiu-Fang Lian
BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common chronic disorder which is followed by various complications. Calpain-10 belongs to a commonly expressed member of the Calpain-like cysteine protease family, which acts as risk marker for some diseases. The purpose of this study is to elucidate correlation between Calpain-10 single-nucleotide polymorphisms (SNPs) and the incidence of OSAHS followed by ischemic stroke (IS). METHODS: OSAHS patients were divided as OSAHS + IS, OSAHS, and control groups, respectively...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28417683/tracheostomy-for-severe-pediatric-obstructive-sleep-apnea-indications-and-outcomes
#2
Christopher J Rizzi, Julian D Amin, Amal Isaiah, Tulio A Valdez, Anita Jeyakumar, Suzanne E Smart, Kevin D Pereira
Objectives (1) To describe characteristics of pediatric patients undergoing tracheostomy for obstructive sleep apnea (OSA). (2) To highlight perioperative events and outcomes of the procedure. Study Design Case series with chart review. Setting Four tertiary care academic children's hospitals. Subjects and Methods Twenty-nine children aged <18 years from January 1, 2010, to December 31, 2015, who underwent tracheostomy for severe OSA, defined as an apnea-hypopnea index (AHI) >10, were included in the study...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28416405/development-validation-and-assessment-of-an-ischemic-stroke-or-transient-ischemic-attack-specific-prediction-tool-for-obstructive-sleep-apnea
#3
Jason J Sico, H Klar Yaggi, Susan Ofner, John Concato, Charles Austin, Jared Ferguson, Li Qin, Lauren Tobias, Stanley Taylor, Carlos A Vaz Fragoso, Vincent McLain, Linda S Williams, Dawn M Bravata
BACKGROUND: Screening instruments for obstructive sleep apnea (OSA), as used routinely to guide clinicians regarding patient referral for polysomnography (PSG), rely heavily on symptomatology. We sought to develop and validate a cerebrovascular disease-specific OSA prediction model less reliant on symptomatology, and to compare its performance with commonly used screening instruments within a population with ischemic stroke or transient ischemic attack (TIA). METHODS: Using data on demographic factors, anthropometric measurements, medical history, stroke severity, sleep questionnaires, and PSG from 2 independently derived, multisite, randomized trials that enrolled patients with stroke or TIA, we developed and validated a model to predict the presence of OSA (i...
April 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28412967/factors-associated-with-lingual-tonsil-hypertrophy-in-canadian-adults
#4
Matthew S Harris, Brian W Rotenberg, Kathryn Roth, Leigh J Sowerby
BACKGROUND: Hypertrophy of the lingual tonsil tissue in the adult patient is thought to contribute to the pathophysiology of obstructive sleep apnea. The underlying etiology of lingual tonsil hypertrophy (LTH) in the adult patient is unclear and likely multifactorial. Previous studies have suggested that the lingual tonsils may undergo compensatory hyperplasia post-tonsillectomy in children, although it is unknown if this occurs or persists into adulthood. The purpose of this study was to determine what factors are associated with LTH in a population of Canadian adults...
April 17, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28408103/effect-of-cpap-on-diastolic-function-in-coronary-artery-disease-patients-with-nonsleepy-obstructive-sleep-apnea-a-randomized-controlled-trial
#5
Helena Glantz, Magnus C Johansson, Erik Thunström, Cecilia Wallentin Guron, Harun Uzel, Mustafa Saygin, Johan Herlitz, Yüksel Peker
BACKGROUND: Obstructive sleep apnea (OSA) has been associated with worse diastolic function in patients with coronary artery disease (CAD). This analysis determined whether continuous positive airway pressure (CPAP) treatment would improve diastolic function in CAD patients with nonsleepy OSA. METHODS: Between December 2005 and November 2010, 244 revascularized CAD patients with nonsleepy OSA (apnea-hypopnea index (AHI) ≥15/h, Epworth Sleepiness Scale [ESS] score<10) were randomly assigned to CPAP or no-CPAP...
March 25, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28402089/perioperative-management-of-obstructive-sleep-apnea-a-systematic-review
#6
Ruggero Corso, Vincenzo Russotto, Cesare Gregoretti, Davide Cattano
Obstructive sleep apnea (OSA) is the leading sleep disordered breathing condition, with a prevalence rate of moderate to severe OSA of approximately 10 - 17% in the general population. Its prevalence in the surgical population seems to be higher. However, a proportion of up to 60% of patients may not have a formal diagnosis at the moment of preoperative visit. OSA is associated with a number of comorbidities and increased perioperative risks. However, most interventions for the perioperative management of OSA patients lack high quality evidence...
April 11, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28397553/preoperative-drug-induced-sleep-endoscopy-improves-the-surgical-approach-to-treatment-of-obstructive-sleep-apnea
#7
Colin Huntley, David Chou, Karl Doghramji, Maurits Boon
OBJECTIVE: Drug induced sleep endoscopy (DISE) allows for preoperative evaluation of the specific site and character of upper airway obstruction in obstructive sleep apnea (OSA). We aim to assess the impact DISE has on customizing the surgical plan and evaluate its role in surgical success. METHODS: We retrospectively reviewed patients undergoing surgery for OSA. We compared those patients undergoing preoperative DISE to those that did not to assess procedures performed and surgical outcomes...
April 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28393717/leptin-levels-in-children-with-obstructive-sleep-apnea-syndrome
#8
Ayhan Söğüt, Şerefden Açıkgöz, Lokman Uzun, Mehmet Birol Uğur, Remzi Altın, Elif Dağlı, Athanasios Kaditis, Refika Ersu
Introduction: The aim of this study is to assess the effect of obstructive sleep apnea syndrome (OSAS) severity on leptin levels in children. Patients and Methods: Children with habitual snoring underwent overnight polysomnography. Fasting venous blood samples were obtained between 8 AM and 9 AM, following the night of the sleep study. Children with an apnea-hypopnea index of ≥ 5/h were included in the moderate-to-severe OSAS group while those with an apnea-hypopnea index of < 5/h formed the mild OSAS/primary snoring group...
December 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28378061/tongue-surgeries-for-pediatric-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#9
REVIEW
Macario Camacho, Michael W Noller, Soroush Zaghi, Lauren K Reckley, Camilo Fernandez-Salvador, Erika Ho, Brandyn Dunn, Dylan Chan
OBJECTIVES: To evaluate the international literature for studies reporting outcomes for obstructive sleep apnea (OSA) in children undergoing isolated tongue surgeries. METHODS: Two authors searched from inception through November 14, 2016 in four databases including PubMed/MEDLINE. RESULTS: 351 studies were screened. Eleven studies (116 children) met criteria. Most children were syndromic and had craniofacial disorders, co-morbidities, or other serious medical issues...
April 4, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28376127/the-doc-screen-feasible-and-valid-screening-for-depression-obstructive-sleep-apnea-osa-and-cognitive-impairment-in-stroke-prevention-clinics
#10
Richard H Swartz, Megan L Cayley, Krista L Lanctôt, Brian J Murray, Ashley Cohen, Kevin E Thorpe, Michelle N Sicard, Karen Lien, Demetrios J Sahlas, Nathan Herrmann
BACKGROUND: Post-stroke Depression, Obstructive sleep apnea (OSA) and Cognitive impairment ("DOC") are associated with greater mortality, worse recovery and poorer quality of life. Best practice recommendations endorse routine screening for each condition; yet, all are under-assessed, diagnosed and treated. We seek to determine the feasibility and validity of an integrated tool ("DOC" screen) to identify stroke clinic patients at high-risk of depression, OSA, and cognitive impairment...
2017: PloS One
https://www.readbyqxmd.com/read/28366339/prevalence-of-obstructive-sleep-apnea-syndrome-in-a-population-of-patients-with-transient-global-amnesia
#11
L Buratti, C Petrelli, E Potente, A Plutino, G Viticchi, L Falsetti, L Provinciali, M Silvestrini
OBJECTIVE: The etiology of transient global amnesia (TGA) is largely undetermined. The aim of this study was to investigate whether the prevalence of obstructive sleep apnea syndrome (OSAS), a condition associated with subtle changes in brain structures involved in memory processes, increases in subjects who have previously experienced a TGA episode. METHODS: Twenty-nine patients who had had a TGA episode were included. A case-control model was used, matching cases with controls by sex, age, and body mass index category...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28366331/risks-associated-with-use-of-stimulant-medications-in-patients-with-obstructive-sleep-apnea-and-cardiomyopathy-a-case-control-study
#12
Meghna P Mansukhani, Bhanu Prakash Kolla, John G Park
OBJECTIVES: Stimulant medications are indicated in patients with obstructive sleep apnea (OSA) who experience sleepiness despite optimal control of sleep-disordered breathing. The safety of stimulant medications in patients with OSA and co-morbid cardiomyopathy is unknown. We performed a case-control study to assess cardiovascular outcomes and mortality risk associated with stimulant use in this group of patients. METHODS: A total of 162 subjects with OSA and cardiomyopathy were identified...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28366141/-leptin-levels-in-children-with-obstructive-sleep-apnea-syndrome
#13
Ayhan Söğüt, Şerefden Açıkgöz, Lokman Uzun, Mehmet Birol Uğur, Remzi Altın, Elif Dağlı, Athanasios Kaditis, Refika Ersu
Introduction: The aim of this study is to assess the effect of obstructive sleep apnea syndrome (OSAS) severity on leptin levels in children. Patients and Methods: Children with habitual snoring underwent overnight polysomnography. Fasting venous blood samples were obtained between 8 AM and 9 AM, following the night of the sleep study. Children with an apnea-hypopnea index of ≥ 5/h were included in the moderate-to-severe OSAS group while those with an apnea-hypopnea index of < 5/h formed the mild OSAS/primary snoring group...
December 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28365911/visual-field-defects-of-the-contralateral-eye-of-non-arteritic-ischemic-anterior-optic-neuropathy-are-they-related-to-sleep-apnea
#14
Florent Aptel, Nischal Aryal-Charles, Renaud Tamisier, Jean-Louis Pépin, Antoine Lesoin, Christophe Chiquet
PURPOSE: To evaluate whether obstructive sleep apnea (OSA) is responsible for the visual field defects found in the fellow eyes of patients with non-arteritic ischemic optic neuropathy (NAION). METHODS: Prospective cross-sectional study. The visual fields of the fellow eyes of NAION subjects with OSA were compared to the visual fields of control OSA patients matched for OSA severity. All patients underwent comprehensive ophthalmological and general examination including Humphrey 24...
April 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28365841/assessing-the-likelihood-of-obstructive-sleep-apnea-a-comparison-of-nine-screening-questionnaires
#15
Kuruswamy Thurai Prasad, Inderpaul Singh Sehgal, Ritesh Agarwal, Ashutosh Nath Aggarwal, Digambar Behera, Sahajal Dhooria
PURPOSE: Several questionnaires are available for the screening of obstructive sleep apnea (OSA). Herein, we compare the performance characteristics of nine available questionnaires for assessing the likelihood of OSA. METHODS: Consecutive subjects who underwent polysomnography at the sleep laboratory of the unit were included. Subjects with obstructive events and apnea hypopnea index (AHI) ≥5 were considered to have OSA. The likelihood ratios (LRs) and other performance characteristics were calculated for the following nine questionnaires: Berlin, modified Berlin, STOP, STOP-Bang and OSA50 questionnaires, sleep apnea clinical score (SACS), Epworth sleepiness scale (ESS), American Society of Anesthesiologists (ASA) checklist, and the elbow sign questionnaire...
April 1, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28356181/validation-of-the-nox-t3-portable-monitor-for-diagnosis-of-obstructive-sleep-apnea-in-chinese-adults
#16
Liyue Xu, Fang Han, Brendan T Keenan, Elizabeth Kneeland-Szanto, Han Yan, Xiaosong Dong, Yuan Chang, Long Zhao, Xueli Zhang, Jing Li, Allan I Pack, Samuel T Kuna
STUDY OBJECTIVES: To evaluate the performance of a portable monitor (Nox-T3, Nox Medical Inc. Reykjavik, Iceland) used to diagnose obstructive sleep apnea in Chinese adults. METHODS: Eighty Chinese adults (mean ± standard deviation age 47.6 ± 14.0 years, 77.5% males, body mass index 27.5 ± 5.4 kg/m2) underwent overnight, unattended home sleep apnea testing (HSAT) with the Nox-T3 portable monitor followed by an overnight in-laboratory polysomnogram (PSG) with simultaneous portable monitor recording...
January 26, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28356180/nocturnal-desaturation-is-associated-with-atrial-fibrillation-in-patients-with-ischemic-stroke-and-obstructive-sleep-apnea
#17
Chung-Yao Chen, Chien-Hui Ho, Chia-Ling Chen, Chung-Chieh Yu
STUDY OBJECTIVES: Both atrial fibrillation (AF) and obstructive sleep apnea (OSA) are risk factors for ischemic stroke. Previous studies suggested that OSA is associated with AF in individuals who have not had a stroke. For better secondary prevention of stroke, this study determined the association between OSA and AF among patients with ischemic stroke. METHODS: This cross-sectional study recruited consecutive patients with subacute ischemic stroke admitted for neurorehabilitation...
March 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28356179/upper-airway-reflexes-are-preserved-during-dexmedetomidine-sedation-in-children-with-down-syndrome-and-obstructive-sleep-apnea
#18
Mohamed Mahmoud, Stacey L Ishman, Keith McConnell, Robert Fleck, Sally Shott, Goutham Mylavarapu, Ephraim Gutmark, Yuanshu Zou, Rhonda Szczesniak, Raouf S Amin
STUDY OBJECTIVES: The assessment of pharyngeal collapsibility is difficult to perform in children under normal sleep. An alternative is to perform the assessment under an anesthetic, such as dexmedetomidine (DEX), that induces non-rapid eye movement (NREM) sleep. The objectives of this study were to compare critical closing airway pressure (Pcrit) obtained during natural sleep to that obtained under DEX in patients with Down syndrome (DS) and persistent obstructive sleep apnea (OSA) and determine whether Pcrit measured under sedation predicts the severity of OSA...
February 20, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28356173/management-of-obstructive-sleep-apnea-in-commercial-motor-vehicle-operators-recommendations-of-the-aasm-sleep-and-transportation-safety-awareness-task-force
#19
Indira Gurubhagavatula, Shannon Sullivan, Amy Meoli, Susheel Patil, Ryan Olson, Michael Berneking, Nathaniel F Watson
The American Academy of Sleep Medicine Sleep and Transportation Safety Awareness Task Force responded to the Federal Motor Carrier Safety Administration and Federal Railroad Administration Advance Notice of Proposed Rulemaking and request for public comments regarding the evaluation of safety-sensitive personnel for moderate-to-severe obstructive sleep apnea (OSA). The following document represents this response. The most salient points provided in our comments are that (1) moderate-to-severe OSA is common among commercial motor vehicle operators (CMVOs) and contributes to an increased risk of crashes; (2) objective screening methods are available and preferred for identifying at-risk drivers, with the most commonly used indicator being body mass index; (3) treatment in the form of continuous positive airway pressure (CPAP) is effective and reduces crashes; (4) CPAP is economically viable; (5) guidelines are available to assist medical examiners in determining whether CMVOs with moderate-to-severe OSA should continue to work without restrictions, with conditional certification, or be disqualified from operating commercial motor vehicles...
March 28, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28355752/-incidence-and-influencing-factors-of-continuous-positive-airway-pressure-treatment-emergent-central-sleep-apnea-in-the-patients-with-obstructive-sleep-apnea-syndrome-at-high-altitude
#20
Z B Miao, Y Y Wang, R Sun, H L Lei, D J Huang, L H Huang, C Y Fan, Y H Lü
Objective: To investigate the incidence of treatment-emergent central sleep apnea (TE-CSA), the characteristics of demography and the influencing factors in patients with obstructive sleep apnea syndrome (OSAS) after initial continuous positive airway pressure (CPAP) titration at high altitude. Methods: Clinical data of 297 patients with OSAS which living in plateau areas (1 000 meters or more above sea level) were retrospectively analyzed in this study from January to December, 2015. All of these patients taken an overnight CPAP titration in the Sleep Medicine Center of First People's Hospital of Yunnan Province...
March 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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