keyword
MENU ▼
Read by QxMD icon Read
search

Anti Th/To antibodies

keyword
https://www.readbyqxmd.com/read/27867885/trimester-specific-reference-interval-for-thyroid-hormones-during-pregnancy-at-a-tertiary-care-hospital-in-haryana-india
#1
Rajesh Rajput, Bhagat Singh, Vasudha Goel, Amit Verma, Shashi Seth, Smiti Nanda
BACKGROUND: Reference intervals for thyroid hormone during pregnancy need to be gestational age, method, and population specific and there is need to establish trimester-specific thyroid levels for the different population across the world. The aim of this study was to establish trimester-specific reference range for thyroid hormone during pregnancy in a tertiary care center in Haryana. MATERIALS AND METHODS: A total of 1430 pregnant women were recruited for the study...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27836015/transplantation-of-gingiva-derived-mesenchymal-stem-cells-ameliorates-collagen-induced-arthritis
#2
Yongchun Gu, Songtao Shi
BACKGROUND: Rheumatoid arthritis (RA) is a chronic, progressive, and inflammatory autoimmune disease which primarily affects the small arthrodial joints. The aim of this study was to test whether transplantation of mesenchymal stem cells derived from gingival tissue (GMSCs) could ameliorate collagen-induced arthritis (CIA), and to explore the role of the FasL/Fas pathway in the underlying mechanism. METHODS: DBA/1 mice with collagen II-induced arthritis were treated with GMSCs from the C57BL/6 J mouse, the B6Smn...
November 11, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27795534/immune-checkpoint-inhibitors-targeting-programmed-cell-death-1-pd-1-in-cancer-therapy
#3
Ryusuke Hatae, Kenji Chamoto
Immune checkpoint inhibitors, especially anti-programmed cell death-1 (PD-1) antibodies, have revolutionized cancer therapy. A PD-1 antibody, nivolumab, was the first of these agents to be approved by the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan, as a new cancer drug for melanoma, in July 2014. While PD-1 mAb therapy has so far been approved only for untreated malignant melanomas and non-small cell lung cancer, many clinical studies on various types of cancer have been conducted worldwide...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27780253/il-12-il-23p40-is-highly-expressed-in-secondary-lymphoid-organs-and-the-cns-during-all-stages-of-eae-but-its-deletion-does-not-affect-disease-perpetuation
#4
Petra D Cravens, Rehana Z Hussain, William A Miller-Little, Li-Hong Ben, Benjamin M Segal, Emily Herndon, Olaf Stüve
BACKGROUND: Interleukin (IL)-12 and IL-23 are heterodimers that share the p40 subunit, and both cytokines are critical in the differentiation of T helper (Th)1 and Th17 cells, respectively. Th1 and Th17 effector cells have been implicated in the pathogenesis of experimental autoimmune encephalitis (EAE), an animal model of the human central nervous system (CNS) autoimmune demyelinating disorder multiple sclerosis (MS). However, ustekinumab, a monoclonal antibody (mAb) against p40 failed to show efficacy over placebo in a phase II clinical trial in patients with MS...
2016: PloS One
https://www.readbyqxmd.com/read/27777982/a-molecular-signature-of-preclinical-rheumatoid-arthritis-triggered-by-dysregulated-ptpn22
#5
Hui-Hsin Chang, Guang-Yaw Liu, Nishant Dwivedi, Bo Sun, Yuko Okamoto, Jennifer D Kinslow, Kevin D Deane, M Kristen Demoruelle, Jill M Norris, Paul R Thompson, Jeffrey A Sparks, Deepak A Rao, Elizabeth W Karlson, Hui-Chih Hung, V Michael Holers, I-Cheng Ho
A unique feature of rheumatoid arthritis (RA) is the presence of anti-citrullinated protein antibodies (ACPA). Several risk factors for RA are known to increase the expression or activity of peptidyl arginine deiminases (PADs), which catalyze citrullination and, when dysregulated, can result in hypercitrullination. However, the consequence of hypercitrullination is unknown and the function of each PAD has yet to be defined. Th cells of RA patients are hypoglycolytic and hyperproliferative due to impaired expression of PFKFB3 and ATM, respectively...
October 20, 2016: JCI Insight
https://www.readbyqxmd.com/read/27761482/immunology-of-neuromyelitis-optica-during-pregnancy
#6
Vahid Davoudi, Kiandokht Keyhanian, Riley M Bove, Tanuja Chitnis
Anti-aquaporin-4 (AQP4) autoantibody plays a key role in the pathogenesis of neuromyelitis optica (NMO). Studies have shown increased relapse rates in patients with NMO during pregnancy and postpartum. High estrogen levels during pregnancy can increase activation-induced cytidine deaminase expression, which is responsible for immunoglobulin production. Additionally, sex hormones may influence antibody glycosylation, with effects on antibody function. Estrogen decreases apoptosis of self-reactive B cells, through upregulation of antiapoptotic molecules...
December 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27754729/is-tgf%C3%AE-as-an-anti-inflammatory-cytokine-required-for-differentiation-of-inflammatory-th17-cells
#7
Arash Pourgholaminejad, Nasser Aghdami, Hossein Baharvand, Seyed Mohammad Moazzeni
T-Helper 17 (TH17) cells are a CD4(+) TH subset that plays a critical role in the pathophysiology of inflammatory disorders, especially chronic forms. It seems that the derivation of TH17 cells from their precursors take place in inflammatory microenvironment. The role of transforming growth factor (TGF)-β as an anti-inflammatory cytokine in TH17 cell differentiation is controversial. To address some of the discrepancies that exist among different studies, this study was undertaken to more clarify the TGFβ role in human TH17 cell differentiation...
October 18, 2016: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/27733582/synovial-il-21-tnf-producing-cd4-t-cells-induce-joint-destruction-in-rheumatoid-arthritis-by-inducing-matrix-metalloproteinase-production-by-fibroblast-like-synoviocytes
#8
Maria C Lebre, Pedro L Vieira, Man Wai Tang, Saïda Aarrass, Boy Helder, Thomas Newsom-Davis, Paul P Tak, Gavin R Screaton
Bone and cartilage destruction is one of the key manifestations of rheumatoid arthritis (RA). Although the role of T helper (Th)17 cells in these processes is clear, the role of IL-21-producing cells T cells has been neglected. We sought to investigate the role of IL-21 in RA by focusing on the functional characteristics of the main producers of this cytokine, synovial CD4(+)IL-21(+) T cells. We show that the frequency of both synovial fluid (SF) CD4(+)IL-21(+) or CD4(+)IL-21(+)TNF(+) T cells in patients with RA was significantly higher compared with patients with psoriatic arthritis (PsA)...
October 12, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27687304/anti-pd-1-therapy-in-patients-with-advanced-melanoma-and-preexisting-autoimmune-disorders-or-major-toxicity-with-ipilimumab
#9
A M Menzies, D B Johnson, S Ramanujam, V G Atkinson, A N M Wong, J J Park, J L McQuade, A N Shoushtari, K K Tsai, Z Eroglu, O Klein, J C Hassel, J A Sosman, A Guminski, R J Sullivan, A Ribas, M S Carlino, M A Davies, S K Sandhu, G V Long
BACKGROUND: Anti-PD-1 antibodies (anti-PD-1) have clinical activity in a number of malignancies. All clinical trials have excluded patients with significant preexisting autoimmune disorders (ADs), and only one has included patients with immune-related adverse events (irAEs) with ipilimumab. We sought to explore the safety and efficacy of anti-PD-1 in such patients. PATIENTS AND METHODS: Patients with advanced melanoma and preexisting ADs and/or major immune-related adverse events (irAEs) with ipilimumab (requiring systemic immunosuppression) that were treated with anti-PD-1 between 1(st) July 2012 and 30(th) September 2015 were retrospectively identified...
September 29, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27670221/advances-in-the-pathophysiology-of-primary-immune-thrombocytopenia
#10
María Perera, Teresa Garrido
OBJECTIVES: Classically, immune thrombocytopenia (ITP) was thought to be caused by the destruction and insufficient production of platelets, as mediated by autoantibodies. More recently other immune mechanisms that contribute to the disease have been discovered. This review attempts to address the main unresolved questions in ITP. METHODS: We review the most current knowledge of the pathophysiology of ITP. Immunological effects of available therapies are also described...
September 27, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27657055/structure-based-reverse-vaccinology-failed-in-the-case-of-hiv-because-it-disregarded-accepted-immunological-theory
#11
Marc H V Van Regenmortel
Two types of reverse vaccinology (RV) should be distinguished: genome-based RV for bacterial vaccines and structure-based RV for viral vaccines. Structure-based RV consists in trying to generate a vaccine by first determining the crystallographic structure of a complex between a viral epitope and a neutralizing monoclonal antibody (nMab) and then reconstructing the epitope by reverse molecular engineering outside the context of the native viral protein. It is based on the unwarranted assumption that the epitope designed to fit the nMab will have acquired the immunogenic capacity to elicit a polyclonal antibody response with the same protective capacity as the nMab...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27631416/blockade-of-programmed-death-1-programmed-death-ligand-pathway-enhances-the-antitumor-immunity-of-human-invariant-natural-killer-t-cells
#12
Toshiko Kamata, Akane Suzuki, Naoko Mise, Fumie Ihara, Mariko Takami, Yuji Makita, Atsushi Horinaka, Kazuaki Harada, Naoki Kunii, Shigetoshi Yoshida, Ichiro Yoshino, Toshinori Nakayama, Shinichiro Motohashi
The role of invariant natural killer T (iNKT) cells in antitumor immunity has been studied extensively, and clinical trials in patients with advanced cancer have revealed a prolonged survival in some cases. In recent years, humanized blocking antibodies against co-stimulatory molecules such as PD-1 have been developed. The enhancement of T cell function is reported to improve antitumor immunity, leading to positive clinical effects. However, there are limited data on the role of PD-1/programmed death ligand (PDL) molecules in human iNKT cells...
December 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27619675/does-native-trypanosoma-cruzi-calreticulin-mediate-growth-inhibition-of-a-mammary-tumor-during-infection
#13
Paula Abello-Cáceres, Javier Pizarro-Bauerle, Carlos Rosas, Ismael Maldonado, Lorena Aguilar-Guzmán, Carlos González, Galia Ramírez, Jorge Ferreira, Arturo Ferreira
BACKGROUND: For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T. cruzi Calreticulin (TcCRT), an endoplasmic reticulum-resident chaperone, translocated-externalized by the parasite, may mediate at least an important part of this effect. Thus, recombinant TcCRT (rTcCRT) has important in vivo antiangiogenic and antitumor activities. However, the relevant question whether the in vivo antitumor effect of T...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27594301/antibody-production-using-a-ciliate-generates-unusual-antibody-glycoforms-displaying-enhanced-cell-killing-activity
#14
Jenny Calow, Anna-Janina Behrens, Sonja Mader, Ulrike Bockau, Weston B Struwe, David J Harvey, Kai U Cormann, Marc M Nowaczyk, Karin Loser, Daniel Schinor, Marcus W W Hartmann, Max Crispin
Antibody glycosylation is a key parameter in the optimization of antibody therapeutics. Here, we describe the production of the anti-cancer monoclonal antibody rituximab in the unicellular ciliate, Tetrahymena thermophila. The resulting antibody demonstrated enhanced antibody-dependent cell-mediated cytotoxicity, which we attribute to unusual N-linked glycosylation. Detailed chromatographic and mass spectrometric analysis revealed afucosylated, oligomannose-type glycans, which, as a whole, displayed isomeric structures that deviate from the typical human counterparts, but whose branches were equivalent to fragments of metabolic intermediates observed in human glycoproteins...
November 2016: MAbs
https://www.readbyqxmd.com/read/27565564/establishment-of-a-simple-cell-based-elisa-for-the-direct-detection-of-abnormal-isoform-of-prion-protein-from-prion-infected-cells-without-cell-lysis-and-proteinase-k-treatment
#15
Zhifu Shan, Takeshi Yamasaki, Akio Suzuki, Rie Hasebe, Motohiro Horiuchi
Prion-infected cells have been used for analyzing the effect of compounds on the formation of abnormal isoform of prion protein (PrP(Sc)). PrP(Sc) is usually detected using anti-prion protein (PrP) antibodies after the removal of the cellular isoform of prion protein (PrP(C)) by proteinase K (PK) treatment. However, it is expected that the PK-sensitive PrP(Sc) (PrP(Sc)-sen), which possesses higher infectivity and conversion activity than the PK-resistant PrP(Sc) (PrP(Sc)-res), is also digested through PK treatment...
July 3, 2016: Prion
https://www.readbyqxmd.com/read/27560798/elevated-neutrophil-lymphocyte-ratio-in-patients-with-euthyroid-chronic-autoimmune-thyreotidis
#16
Havva Keskin, Y Kaya, K Cadirci, C Kucur, E Ziypak, E Simsek, H Gozcu, S Arikan, A Carlioglu
OBJECTIVE: The neutrophil-lymphocyte ratio (NLR), determined from peripheral blood, is accepted as an available and practical indicator of the systemic inflammation. In this study, we aimed to determine whether the NLR was higher in euthyroid chronic autoimmune thyreotidis (CAT) patients compared to a healthy control group. METHODS: A total of 112 patients were enrolled in this study, including 59 patients with euthyroid CAT on any form of therapy and 53 healthy controls...
July 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27540538/value-of-foxp3-expressing-t-regulatory-cells-in-renal-tissue-in-lupus-nephritis-an-immunohistochemical-study
#17
Marwa M Shakweer, Maha Behairy, Nadia G Elhefnawy, Tamer W Elsaid
BACKGROUND: Forkhead box P3 (Foxp3) functions as a master regulator in the development and function of T-regulatory (Treg) cells. Recent studies have shown that autoimmune diseases including systemic lupus erythematosus (SLE) are associated with an imbalance with the Treg cells and T helper (Th) subtypes. OBJECTIVES: To evaluate immunohistochemical expression of Foxp3 positive Treg cells in lupus nephritis (LN) and analyze its association with clinicopathologic parameters...
July 2016: Journal of Nephropathology
https://www.readbyqxmd.com/read/27539120/serum-antibody-profile-during-colonization-of-the-mouse-gut-by-candida-albicans-relevance-for-protection-during-a-systemic-infection
#18
Blanca Huertas, Daniel Prieto, Aida Pitarch, Concha Gil, Jesus Pla, Rosalia Diez-Orejas
Candida albicans is a commensal microorganism in the oral cavity, gastrointestinal and urogenital tracts of most individuals that acts like as an opportunistic pathogen when the host immune responses is reduced. Here, we settled down different immunocompetent murine models, to analyze the antibody responses to the C. albicans proteome during commensalism, commensalism followed by infection, and infection (C, C+I and I models, respectively). Serum anti-C. albicans IgG antibody levels were higher in colonized mice than in infected mice...
August 18, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27536036/seroprevalence-of-human-brucellosis-in-and-around-jammu-india-using-different-serological-tests
#19
H K Sharma, S K Kotwal, D K Singh, M A Malik, Arvind Kumar, Rajagunalan, M Singh
AIM: Brucellosis is a disease of zoonotic importance as it affects both human as well as animal's health, and therefore, directly affects animal productivity and human efficiency. Therefore, a study was conducted to estimate the seroprevalence of brucellosis in humans in Jammu and surrounding areas. MATERIALS AND METHODS: A total of 121 sera samples from humans occupied with professional related to animals were collected and tested for anti-Brucella antibodies by Rose Bengal plate test (RBPT), modified RBPT (mRBPT), standard tube agglutination test (STAT), and indirect enzyme-linked immunosorbent assay (I-ELISA)...
July 2016: Veterinary World
https://www.readbyqxmd.com/read/27519317/localization-of-trkb-and-p75-receptors-in-peritoneal-and-deep-infiltrating-endometriosis-an-immunohistochemical-study
#20
Agung Dewanto, Jozsef Dudas, Rudolf Glueckert, Sylvia Mechsner, Anneliese Schrott-Fischer, Ludwig Wildt, Beata Seeber
BACKGROUND: The roles of the neurotrophins NGF (Neurotrophic growth factor) and BDNF (brain-derived neurotrophic factor) in neuronal growth and development are already known. Meanwhile, the neurotrophin receptors TrkA (tropomyosin related kinase A), TrkB, and p75 are important for determining the fate of cells. In endometriosis, this complex system has not been fully elucidated yet. The aim of this study was to evaluate the expression and location of these neurotrophins and their receptors in peritoneal (PE) and deep infiltrating endometriotic (DIE) tissues and to measure and compare the density of nerve fibers in the disease subtypes...
2016: Reproductive Biology and Endocrinology: RB&E
keyword
keyword
118599
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"