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https://www.readbyqxmd.com/read/28087310/clinical-features-and-three-year-outcomes-of-takotsubo-stress-cardiomyopathy-observational-data-from-one-center
#1
Sigita Glaveckaitė, Pranas Šerpytis, Dovilė Pečiūraitė, Roma Puronaitė, Nomeda Valevičienė
OBJECTIVE: The natural history, management, and outcome of Takotsubo (stress) cardiomyopathy (TTC) is not clear. The aim of this study was to investigate clinical features, define prognostic predictors, and assess the clinical course and outcomes of patients with TTC. METHODS: We analyzed 64 patients (52 women) meeting the proposed Mayo Clinic diagnostic criteria for TTC. All patients were treated at Vilnius University Hospital Santariskiu Klinikos from 2001-01-01 to 2014-11-27...
November 16, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28077642/studies-on-the-interaction-of-tumor-derived-hd5-alpha-defensins-with-adenoviruses-and-implications-for-oncolytic-adenovirus-therapy
#2
Charles Vragniau, Jens-Martin Hübner, Peter Beidler, Sucheol Gil, Kamola Saydaminova, Zhuo-Zhuang Lu, Roma Yumul, Hongjie Wang, Maximilian Richter, Pavel Sova, Charles Drescher, Pascal Fender, André Lieber
: Defensins are small anti-microbial peptides capable of neutralizing human adenovirus (HAdV) in vitro by binding capsid proteins and blocking endosomal escape of virus. In humans, the alpha defensin HD5 is produced by specialized epithelial cells of the gastro-intestinal and genito-urinary tracts. Here we demonstrate that HD5 is also expressed as an active, secreted peptide by epithelial ovarian and lung cancer cells in situ, in patient biopsies. This finding triggered us to study the role of HD5 in infection and spread of replication-competent, oncolytic HAdV type 3 virus...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28069561/cancer-survivors-experience-with-telehealth-a-systematic-review-and-thematic-synthesis
#3
REVIEW
Anna Cox, Grace Lucas, Afrodita Marcu, Marianne Piano, Wendy Grosvenor, Freda Mold, Roma Maguire, Emma Ream
BACKGROUND: Net survival rates of cancer are increasing worldwide, placing a strain on health service provision. There is a drive to transfer the care of cancer survivors-individuals living with and beyond cancer-to the community and encourage them to play an active role in their own care. Telehealth, the use of technology in remote exchange of data and communication between patients and health care professionals (HCPs), is an important contributor to this evolving model of care. Telehealth interventions are "complex," and understanding patient experiences of them is important in evaluating their impact...
January 9, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28057003/discrimination-against-childbearing-romani-women-in-maternity-care-in-europe-a-mixed-methods-systematic-review
#4
REVIEW
Helen L Watson, Soo Downe
BACKGROUND: Freedom from discrimination is one of the key principles in a human rights-based approach to maternal and newborn health. OBJECTIVE: To review the published evidence on discrimination against Romani women in maternity care in Europe, and on interventions to address this. SEARCH STRATEGY: A systematic search of eight electronic databases was undertaken in 2015 using the terms "Roma" and "maternity care". A broad search for grey literature included the websites of relevant agencies...
January 5, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28011908/genital-injury-signatures-and-microbiome-alterations-associated-with-depot-medroxyprogesterone-acetate-usage-and-intravaginal-drying-practices
#5
Kenzie D Birse, Laura M Romas, Brandon L Guthrie, Peter Nilsson, Rose Bosire, James Kiarie, Carey Farquhar, Kristina Broliden, Adam D Burgener
BACKGROUND: Increasing evidence suggests that depot medroxyprogesterone acetate (DMPA) and intravaginal practices may be associated with an increased risk of HIV infection; however the mechanisms are not fully understood. This study evaluated the effect of DMPA and intravaginal practices on the genital mucosal proteome and microbiome to gain mechanistic insights. METHODS: Cervicovaginal secretions from 86 Kenyan women, including self-reported DMPA (n=23) and non-hormonal contraceptive users (n=63), and women who practice vaginal drying (n=46) were analyzed using tandem-mass spectrometry in a cross sectional manner...
December 23, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28010839/a-systematic-study-on-the-effect-of-noise-and-shift-on-multivariate-figures-of-merit-of-second-order-calibration-algorithms
#6
Mohammad Ahmadvand, Hadi Parastar, Hassan Sereshti, Alejandro Olivieri, Roma Tauler
In the present study, multivariate analytical figures of merit (AFOM) for three well-known second-order calibration algorithms, parallel factor analysis (PARAFAC), PARAFAC2 and multivariate curve resolution-alternating least squares (MCR-ALS), were investigated in simulated hyphenated chromatographic systems including different artifacts (e.g., noise and peak shifts). Different two- and three-component systems with interferences were simulated. Resolved profiles from the target components were used to build calibration curves and to calculate the multivariate AFOMs, sensitivity (SEN), analytical sensitivity (γ), selectivity (SEL) and limit of detection (LOD)...
February 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27958599/association-between-oral-habits-mouth-breathing-and-malocclusion
#7
C Grippaudo, E G Paolantonio, G Antonini, R Saulle, G La Torre, R Deli
The ratio of bad habits, mouth breathing and malocclusion is an important issue in view of prevention and early treatment of disorders of the craniofacial growth. While bad habits can interfere with the position of the teeth and normal pattern of skeletal growth, on the other hand obstruction of the upper airway, resulting in mouth breathing, changes the pattern of craniofacial growth causing malocclusion. Our crosssectional study, carried out on 3017 children using the ROMA index, was developed to verify if there was a significant correlation between bad habits/mouth breathing and malocclusion...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27919964/implementing-the-risk-of-ovarian-malignancy-algorithm-adding-obesity-as-a-predictive-factor
#8
Emanuela Anastasi, Danila Capoccia, Teresa Granato, Gianfranco Silecchia, Mario Rizzello, Maria Grazia Porpora, Luigi Frati, Antonio Angeloni, Frida Leonetti
AIM: To evaluate whether obesity represents a risk factor for the onset of ovarian cancer. PATIENTS AND METHODS: One hundred and sixty-three patients with a body mass index (BMI) >30 kg/m(2) (group 1) and 130 women with a BMI of <25 kg/m(2) (group 2) were included in the study. RESULTS: A Risk of Ovarian Malignancy Algorithm (ROMA) index above the cut-off (>13%) was found in 24.5% of group 1 patients, whereas a high ROMA score was identified in 5...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27876443/are-we-certain-about-which-measure-of-intolerance-of-uncertainty-to-use-yet
#9
Vincenzo G Roma, Debra A Hope
Intolerance of Uncertainty (IU) has been understood as a dispositional tendency to view the presence of negative events as unacceptable and threatening, regardless of the likelihood of those events occurring. The preference over the 12-item vs. 27-item of the IUS has been central to debate. The goals of the present study were to evaluate two competing models of measuring IU with model-fitting analyses and explore model invariance of gender (e.g. men vs. women). A sample of 980 individuals completed an online IUS survey...
November 23, 2016: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/27847365/contribution-of-maternal-immunity-to-decreased-rotavirus-vaccine-performance-in-low-and-middle-income-countries
#10
Katayi Mwila, Roma Chilengi, Michelo Simuyandi, Sallie R Permar, Sylvia Becker-Dreps
The role of maternal immunity received by infants either transplacentally or orally from breast milk on rotavirus vaccine (RV) performance is evaluated. Breast feeding withholding has no effect on vaccine response, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low and middle income countries (LMIC) remain and further research is needed to shed more light on these issues...
November 9, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27727032/the-roma-vaccination-gap-evidence-from-twelve-countries-in-central-and-south-east-europe
#11
Laetitia Duval, François-Charles Wolff, Martin McKee, Bayard Roberts
AIM: To investigate differences in vaccination coverage between Roma and otherwise comparable non-Roma children, including factors associated with the vaccination gap, health care access and discrimination faced by Roma. METHODS: We analyse data from the Roma Regional Survey 2011 implemented in twelve countries of Central and South-East Europe. Our sample comprises 8233 children aged up to 6 with 7072 Roma children and 1161 non-Roma children. Estimates of the Roma vaccination gap are estimated using Logit regressions...
October 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27717696/falls-and-their-association-with-physical-tests-functional-capacity-clinical-and-demographic-factors-in-patients-with-rheumatoid-arthritis
#12
Mariana de Almeida Lourenço, Izabela Roma, Marcos Renato de Assis
OBJECTIVE: To evaluate the occurrence of falls reported by rheumatoid arthritis (RA) patients and its relation to disease activity, functional capacity and physical fitness. MATERIAL AND METHODS: A cross-sectional study constituted by a sample of 97 RA patients from the city of Marília (SP) from 2012 to 2013, were assessed for disease activity. Instruments validated for Brazilian population in order to evaluate physical and functional capacity were used. Data analysis was carried out with descriptive statistics, Spearman correlation and Chi-squared test, considering p<0...
September 22, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27694159/low-vaccination-coverage-of-greek-roma-children-amid-economic-crisis-national-survey-using-stratified-cluster-sampling
#13
Dimitris Papamichail, Ioanna Petraki, Chrisoula Arkoudis, Agis Terzidis, Emmanouil Smyrnakis, Alexis Benos, Takis Panagiotopoulos
BACKGROUND: Research on Roma health is fragmentary as major methodological obstacles often exist. Reliable estimates on vaccination coverage of Roma children at a national level and identification of risk factors for low coverage could play an instrumental role in developing evidence-based policies to promote vaccination in this marginalized population group. METHODS: We carried out a national vaccination coverage survey of Roma children. Thirty Roma settlements, stratified by geographical region and settlement type, were included; 7-10 children aged 24-77 months were selected from each settlement using systematic sampling...
October 2, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/27646618/quality-of-life-and-patient-satisfaction-with-family-practice-care-in-a-roma-population-with-chronic-conditions-in-northeast-slovenia
#14
Erika Zelko, Igor Švab, Danica Rotar Pavlič
OBJECTIVES: Health-related quality of life (HRQoL) measures a patient's subjective experience of his or her health status. We aimed to show how the presence of chronic diseases and satisfaction with family physicians (FPs) were associated with the HRQoL of a Roma population. METHODS: A cross-sectional study was carried out in May 2011 on a representative sample of 650 Roma living in Prekmurje, Slovenia. The EQ-5D questionnaire was used for measuring the HRQoL of the Roma...
March 2015: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/27644127/pre-and-postdiagnostic-diet-in-relation-to-mortality-among-breast-cancer-survivors-in-the-cps-ii-nutrition-cohort
#15
Marjorie L McCullough, Susan M Gapstur, Roma Shah, Peter T Campbell, Ying Wang, Colleen Doyle, Mia M Gaudet
PURPOSE: Due to the limited evidence on the role of diet and cause-specific mortality among breast cancer survivors, current nutrition guidelines for this population are consistent with those for cancer prevention. We evaluated whether diets consistent with the American Cancer Society recommendations for cancer prevention were associated with risk of death in breast cancer survivors. METHODS: Participants reported information on diet and other factors at baseline in 1992-1993 and twice during follow-up...
September 19, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27629577/dietary-energy-density-and-postmenopausal-breast-cancer-incidence-in-the-cancer-prevention-study-ii-nutrition-cohort
#16
Terryl J Hartman, Susan M Gapstur, Mia M Gaudet, Roma Shah, W Dana Flanders, Ying Wang, Marjorie L McCullough
BACKGROUND: Dietary energy density (ED) is a measure of diet quality that estimates the amount of energy per unit of food (kilocalories per gram) consumed. Low-ED diets are generally high in fiber and fruits and vegetables and low in fat. Dietary ED has been positively associated with body mass index (BMI) and other risk factors for postmenopausal breast cancer. OBJECTIVE: We evaluated the associations of total dietary ED and energy-dense (high-ED) foods with postmenopausal breast cancer incidence...
October 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27613936/high-prevalence-of-smoking-in-the-roma-population-seems-to-have-no-genetic-background
#17
Szilvia Fiatal, Réka Tóth, Ágota Moravcsik-Kornyicki, Zsigmond Kósa, János Sándor, Martin McKee, Róza Ádány
INTRODUCTION: The prevalence of smoking in Romani of both genders is significantly higher than in the general population. Our aim was to determine whether a genetic susceptibility contributes to the high prevalence of smoking among Roma in a study based on data collected from cross-sectional surveys. METHODS: Twenty single nucleotide polymorphisms known to be closely related to smoking behavior were investigated in DNA samples of Hungarian Roma (N = 1273) and general (N = 2388) populations...
December 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27568335/comparison-of-the-effects-of-acute-and-chronic-administration-of-tetrahydroisoquinoline-amines-on-the-in-vivo-dopamine-release-a-microdialysis-study-in-the-rat-striatum
#18
Agnieszka Wąsik, Irena Romańska, Lucyna Antkiewicz-Michaluk
The etiology of Parkinson's disease (PD) may involve endogenous and exogenous factors. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), which was shown to be neurotoxic for dopaminergic neurons, is one of such factors, thus it can be used to construct an animal model of PD. In contrast, 1,2,3,4-tetrahydroisoquinoline (TIQ) and 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) produce neuroprotective effects acting as monoamino oxidase (MAO) inhibitors and free radical scavengers that reduce oxidative stress in the mammalian brain...
November 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27499385/association-between-hepatitis-b-co-infection-and-elevated-liver-stiffness-among-hiv-infected-adults-in-lusaka-zambia
#19
Michael J Vinikoor, Lloyd Mulenga, Alice Siyunda, Kalo Musukuma, Roma Chilengi, Carolyn Bolton Moore, Benjamin H Chi, Mary-Ann Davies, Matthias Egger, Gilles Wandeler
OBJECTIVE: To describe liver disease epidemiology among HIV-infected individuals in Zambia. METHODS: We recruited HIV-infected adults (≥18 years) at antiretroviral therapy initiation at two facilities in Lusaka. Using vibration controlled transient elastography, we assessed liver stiffness, a surrogate for fibrosis/cirrhosis, and analysed liver stiffness measurements (LSM) according to established thresholds (>7.0 kPa for significant fibrosis and >11.0 kPa for cirrhosis)...
November 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27476084/safety-analysis-association-with-response-and-previous-treatments-of-everolimus-and-exemestane-in-181-metastatic-breast-cancer-patients-a-multicenter-italian-experience
#20
L Moscetti, P Vici, T Gamucci, C Natoli, E Cortesi, P Marchetti, D Santini, R Giuliani, I Sperduti, M Mauri, L Pizzuti, M L Mancini, M A Fabbri, V Magri, L Iezzi, V Sini, L D'Onofrio, L Mentuccia, A Vaccaro, S Ramponi, C L Roma, E M Ruggeri
PURPOSE: The everolimus and exemestane combination represents a treatment option for the endocrine sensitive metastatic breast cancer (MBC) patients. The toxicity profile reported in the Bolero 2 trial showed the feasibility in the selected patients. Few data are available for the unselected population. METHODS: In order to evaluate the safety in the unselected population of the clinical practice and to evaluate a possible association of toxicities with previous treatments, clinical data from 181 consecutive patients were retrospectively collected...
October 2016: Breast: Official Journal of the European Society of Mastology
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