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GABA AND Supplement

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https://www.readbyqxmd.com/read/27808555/randomized-open-label-trial-of-baclofen-for-relapse-prevention-in-alcohol-dependence
#1
Manushree Gupta, Pankaj Verma, Rajesh Rastogi, Sheetal Arora, Deeksha Elwadhi
BACKGROUND: Alcohol dependence is a progressive chronic disorder characterized by narrowing of the drinking repertoire, salience of drinking, tolerance and withdrawal phenomenon, compulsion to drink, and frequent relapses. Baclofen has been shown to promote abstinence, to reduce craving, and to reduce anxiety in alcohol-dependent individuals, and it promises to be a useful agent, although clinical data are limited at present. OBJECTIVE: The current study aimed to test the utility of baclofen, a GABA agonist, in improving the relapse rates in alcohol-dependent subjects...
November 3, 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/27790703/the-effect-of-fermented-buckwheat-on-producing-l-carnitine-and-gamma-aminobutyric-acid-gaba-enriched-designer-eggs
#2
Namhyeon Park, Tae-Kyung Lee, Thi Thanh Hanh Nguyen, Eun-Bae An, Nahyun M Kim, Young-Hyun You, Tae-Sub Park, Doman Kim
BACKGROUND: The potential of fermented buckwheat as feed additives was studied to increase L-carnitine and gamma-aminobutyric acid (GABA) in designer eggs. Buckwheat contains high levels of lysine, methionine, and glutamate, which are precursors for the synthesis of L-carnitine and GABA. Rhizopus oligosporus was used for the fermentation of buckwheat to produce L-carnitine and GABA that exert positive effects like enhanced metabolism, antioxidant activities, immunity, and blood pressure control...
October 28, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27657037/the-anticonvulsant-activity-of-a-flavonoid-rich-extract-from-orange-juice-involves-both-nmda-and-gaba-benzodiazepine-receptor-complexes
#3
Rita Citraro, Michele Navarra, Antonio Leo, Eugenio Donato Di Paola, Ermenegildo Santangelo, Pellegrino Lippiello, Rossana Aiello, Emilio Russo, Giovambattista De Sarro
The usage of dietary supplements and other natural products to treat neurological diseases has been growing over time, and accumulating evidence suggests that flavonoids possess anticonvulsant properties. The aim of this study was to examine the effects of a flavonoid-rich extract from orange juice (OJe) in some rodent models of epilepsy and to explore its possible mechanism of action. The genetically audiogenic seizures (AGS)-susceptible DBA/2 mouse, the pentylenetetrazole (PTZ)-induced seizures in ICR-CD1 mice and the WAG/Rij rat as a genetic model of absence epilepsy with comorbidity of depression were used...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27628921/ameliorative-effect-of-synthetic-%C3%AE-aminobutyric-acid-gaba-on-performance-traits-antioxidant-status-and-immune-response-in-broiler-exposed-to-cyclic-heat-stress
#4
Naila Chand, Sher Muhammad, Rifat Ullah Khan, Ibrahim Abdullah Alhidary, Zia Ur Rehman
The aim of this study was to find the effect of synthetic γ-aminobutyric acid (GABA) on the performance, antioxidant status, and immune response in broiler exposed to summer stress. A total of 400-day-old male broiler chickens (Ross 308) was randomly distributed into five treatments (5 replicates). One group served as a control (basal diet only) while the others were supplemented with GABA at the rate of 25 (GABA-25), 50 (GABA 50), 75 (GABA-75), and 100 (GABA-100) mg/kg feed. The experiment was continued for 35 days...
December 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27621692/effects-of-germinated-brown-rice-addition-on-the-flavor-and-functionality-of-yogurt
#5
Mi-Hye Kim, Sung-Il Ahn, Chan-Mook Lim, Jin-Woo Jhoo, Gur-Yoo Kim
This study aimed to investigate the functional and physicochemical properties of yogurt, supplemented with germinated brown rice (GBR) containing γ-aminobutyric acid (GABA), during storage. GBR was produced by soaking brown rice at 30℃, and saccharified germinated brown rice (SGBR) was produced by treating brown rice with α- and β-amylase for 1 h, at 80℃ and 60℃, respectively. Yogurt was manufactured using a commercial starter (YC-X11, CHR. Hansen, Denmark) at 37℃ for 12 h. The fatty acids and GABA contents were analyzed using GC and HPLC, respectively...
2016: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/27479478/nonpharmacological-alternatives-to-benzodiazepine-drugs-for-the-treatment-of-anxiety-in-outpatient-populations-a-literature-review
#6
Lois M Platt, Amy Irene Whitburn, Alexander G Platt-Koch, Ronald L Koch
Overuse of benzodiazepine drugs to treat anxiety, mood, and sleep disorders is a growing problem in clinical practice. GABAergic medications (benzodiazepine drugs in particular) have side effects, drug interactions, and the potential to create tolerance and dependence in users. GABA-enhancing dietary supplements have similar and unique risks. Natural, non-chemical, anxiolytic treatments exist and can be safely recommended to patients. Three such treatments have been the focus of study in the past 20 years: mindfulness, meditation, and yoga...
August 1, 2016: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/27458444/gaba-production-in-lactococcus-lactis-is-enhanced-by-arginine-and-co-addition-of-malate
#7
Valérie Laroute, Chonthicha Yasaro, Waranya Narin, Roberto Mazzoli, Enrica Pessione, Muriel Cocaign-Bousquet, Pascal Loubière
Lactococcus lactis NCDO 2118 was previously selected for its ability to decarboxylate glutamate to γ-aminobutyric acid (GABA), an interesting nutritional supplement able to improve mood and relaxation. Amino acid decarboxylation is generally considered as among the biochemical systems allowing lactic acid bacteria to counteracting acidic stress and obtaining metabolic energy. These strategies also include arginine deiminase pathway and malolactic fermentation but little is known about their possible interactions of with GABA production...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27438707/pyridoxine-supplementation-improves-the-activity-of-recombinant-glutamate-decarboxylase-and-the-enzymatic-production-of-gama-aminobutyric-acid
#8
Yan Huang, Lingqia Su, Jing Wu
Glutamate decarboxylase (GAD) catalyzes the irreversible decarboxylation of L-glutamate to the valuable food supplement γ-aminobutyric acid (GABA). In this study, GAD from Escherichia coli K12, a pyridoxal phosphate (PLP)-dependent enzyme, was overexpressed in E. coli. The GAD produced in media supplemented with 0.05 mM soluble vitamin B6 analog pyridoxine hydrochloride (GAD-V) activity was 154.8 U mL-1, 1.8-fold higher than that of GAD obtained without supplementation (GAD-C). Purified GAD-V exhibited increased activity (193...
2016: PloS One
https://www.readbyqxmd.com/read/27281617/prevention-of-pancreatic-cancer-in-a-hamster-model-by-camp-decrease
#9
Jheelam Banerjee, Arokya M S Papu John, Mohammed H Al-Wadei, Hildegard M Schuller
Smoking and alcoholism are risk factors for the development of pancreatitis-associated pancreatic ductal adenocarcinoma (PDAC). We have previously shown that these cancers overexpressed stress neurotransmitters and cyclic adenosine monophosphate (cAMP) while the inhibitory neurotransmitter γ-aminobutyric acid (GABA) was suppressed. Using a hamster model, the current study has tested the hypothesis that cAMP decrease by GABA supplementation in the drinking water prevents the development of pancreatitis-associated PDAC...
June 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27176157/remote-prenatal-care-monitoring-with-digital-health-tools-can-reduce-visit-frequency-while-improving-satisfaction-3
#10
Kathryn I Marko, Nihar Ganju, James Brown, Joshua Benham, Nancy D Gaba
INTRODUCTION: A high frequency of in-clinic visits is standard for prenatal surveillance. Yet in studies, reduction in prenatal care visits is not correlated with adverse perinatal outcomes for low-risk pregnancies. However, it is associated with decreased patient satisfaction. This study sought to measure the effect of reducing the frequency of prenatal visits while applying mobile/digital health technology for improved patient satisfaction and equivalent outcomes in low-risk pregnancies...
May 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27161372/the-influence-of-manganese-and-glutamine-intake-on-antioxidants-and-neurotransmitter-amino-acids-levels-in-rats-brain
#11
Maria Szpetnar, Dorota Luchowska-Kocot, Anna Boguszewska-Czubara, Jacek Kurzepa
Depending on the concentration, Mn can exert protective or toxic effect. Potential mechanism for manganese neurotoxicity is manganese-induced oxidative stress. Glutamine supplementation could reduce manganese-induced neurotoxicity and is able to influence the neurotransmission processes. The aim of this study was to investigate whether the long term administration of manganese (alone or in combination with glutamine) in dose and time dependent manner could affect the selected parameters of oxidative-antioxidative status (superoxide dismutase and glutathione peroxidase activities, concentrations of vitamin C and malonic dialdehyde) and concentrations of excitatory (Asp, Glu) and inhibitory amino acids (GABA, Gly) in the brain of rats...
August 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27153397/mechanisms-and-disease-associations-of-haplotype-dependent-allele-specific-dna-methylation
#12
Catherine Do, Charles F Lang, John Lin, Huferesh Darbary, Izabela Krupska, Aulona Gaba, Lynn Petukhova, Jean-Paul Vonsattel, Mary P Gallagher, Robin S Goland, Raphael A Clynes, Andrew Dwork, John G Kral, Catherine Monk, Angela M Christiano, Benjamin Tycko
Haplotype-dependent allele-specific methylation (hap-ASM) can impact disease susceptibility, but maps of this phenomenon using stringent criteria in disease-relevant tissues remain sparse. Here we apply array-based and Methyl-Seq approaches to multiple human tissues and cell types, including brain, purified neurons and glia, T lymphocytes, and placenta, and identify 795 hap-ASM differentially methylated regions (DMRs) and 3,082 strong methylation quantitative trait loci (mQTLs), most not previously reported...
May 5, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27129463/the-effects-of-creatine-supplementation-on-striatal-neural-progenitor-cells-depend-on-developmental-stage
#13
Robert H Andres, Angelique D Ducray, Lukas Andereggen, Tabea Hohl, Uwe Schlattner, Theo Wallimann, Hans R Widmer
Transplantation of neural progenitor cells (NPCs) is a promising experimental therapy for Huntington's disease (HD). The variables responsible for the success of this approach, including selection of the optimal developmental stage of the grafted cells, are however largely unknown. Supporting cellular energy metabolism by creatine (Cr) supplementation is a clinically translatable method for improving cell transplantation strategies. The present study aims at investigating differences between early (E14) and late (E18) developmental stages of rat striatal NPCs in vitro...
August 2016: Amino Acids
https://www.readbyqxmd.com/read/27062388/carnosine-and-anserine-homeostasis-in-skeletal-muscle-and-heart-is-controlled-by-%C3%AE-alanine-transamination
#14
Laura Blancquaert, Shahid P Baba, Sebastian Kwiatkowski, Jan Stautemas, Sanne Stegen, Silvia Barbaresi, Weiliang Chung, Adjoa A Boakye, J David Hoetker, Aruni Bhatnagar, Joris Delanghe, Bert Vanheel, Maria Veiga-da-Cunha, Wim Derave, Inge Everaert
KEY POINTS: Using recombinant DNA technology, the present study provides the first strong and direct evidence indicating that β-alanine is an efficient substrate for the mammalian transaminating enzymes 4-aminobutyrate-2-oxoglutarate transaminase and alanine-glyoxylate transaminase. The concentration of carnosine and anserine in murine skeletal and heart muscle depends on circulating availability of β-alanine, which is in turn controlled by degradation of β-alanine in liver and kidney...
September 1, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27048382/maternal-diet-of-polyunsaturated-fatty-acid-altered-the-cell-proliferation-in-the-dentate-gyrus-of-hippocampus-and-influenced-glutamatergic-and-serotoninergic-systems-of-neonatal-female-rats
#15
Mimi Tang, Min Zhang, Hualin Cai, Huande Li, Pei Jiang, Ruili Dang, Yiping Liu, Xin He, Ying Xue, Lingjuan Cao, Yanqin Wu
BACKGROUND: Long-chain polyunsaturated fatty acids (PUFAs) are major components of the phospholipids that forming the cell membrane. Insufficient availability of PUFAs during prenatal period decreases accretion of docosahexaenoic acid (DHA) in the developing brain. DHA deficiency is associated with impaired attention and cognition, and would precipitate psychiatric symptoms. However, clinical studies on the potential benefits of dietary DHA supplementation to neural development have yielded conflicting results...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27013462/influence-of-gaba-and-gaba-producing-lactobacillus-brevis-dpc-6108-on-the-development-of-diabetes-in-a-streptozotocin-rat-model
#16
T M Marques, E Patterson, R Wall, O O'Sullivan, G F Fitzgerald, P D Cotter, T G Dinan, J F Cryan, R P Ross, C Stanton
The aim of this study was to investigate if dietary administration of γ-aminobutyric acid (GABA)-producing Lactobacillus brevis DPC 6108 and pure GABA exert protective effects against the development of diabetes in streptozotocin (STZ)-induced diabetic Sprague Dawley rats. In a first experiment, healthy rats were divided in 3 groups (n=10/group) receiving placebo, 2.6 mg/kg body weight (bw) pure GABA or L. brevis DPC 6108 (~10(9)microorganisms). In a second experiment, rats (n=15/group) were randomised to five groups and four of these received an injection of STZ to induce type 1 diabetes...
June 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/26967144/correlation-of-doxorubicin-delivery-and-tumor-necrosis-after-drug-eluting-bead-transarterial-chemoembolization-of-rabbit-vx2-liver-tumors
#17
Ron C Gaba, Rajyasree Emmadi, Ahmad Parvinian, Leigh C Casadaban
Purpose To quantify the correlation between doxorubicin (DOX) delivery and tumor necrosis after drug-eluting bead (DEB) transarterial chemoembolization (TACE). Materials and Methods In this animal care committee-approved study, New Zealand white rabbit VX2 liver tumors were treated transarterially with DOX-loaded 70-150-μm DEBs in five treatment groups with varying drug doses: sham (saline), 0 mg, 12.5 mg, 25 mg, and 37.5 mg. DEB TACE was followed by 3- and 7-day sacrifice, tumor harvest, and sectioning. Drug delivery was assessed by using fluorescence imaging, and tumor necrosis was quantified by means of histologic analysis...
September 2016: Radiology
https://www.readbyqxmd.com/read/26935476/maternal-vitamin-b6-deficient-or-supplemented-diets-on-expression-of-genes-related-to-gabaergic-serotonergic-or-glutamatergic-pathways-in-hippocampus-of-rat-dams-and-their-offspring
#18
Mara Ribeiro Almeida, Lawrence Mabasa, Courtney Crane, Chung S Park, Vinícius Paula Venâncio, Maria Lourdes Pires Bianchi, Lusânia Maria Greggi Antunes
SCOPE: Vitamin B6 plays crucial roles on brain development and its maternal deficiency impacts the gamma-aminobutyric acid (GABA)ergic, serotonergic, glutamatergic, and dopaminergic systems in offspring. However, the molecular mechanisms underlying these neurological changes are not well understood. Thus, we aimed at evaluating which components of those neurotransmitter metabolism and signaling pathways can be modulated by maternal vitamin B6 -deficient or B6 -supplementated diets in the hippocampus of rat dams and their offspring...
July 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/26934627/the-effect-of-epilepsy-and-antiepileptic-drugs-on-sexual-reproductive-and-gonadal-health-of-adults-with-epilepsy
#19
Sherifa A Hamed
Epilepsy is a common chronic medical illness. Hyposexuality is the most frequent abnormality in men and women with epilepsy. In men with epilepsy, hypoandrogenimia, hypogonadism and sperm abnormalities are common. Testicular atrophy was also infrequently reported. In women with epilepsy, hyperandrogenism, polycystic ovaries (PCOs) and PCO syndrome are frequent. Decreased serum free testosterone, dehydroepiandrosterone levels, free androgen index and free testosterone/leutinizing hormone (LH) ratio and increased sex hormone binding globulin, estradiol, prolactin, LH, follicle stimulating hormone (FSH) levels and LH/FSH ratio are common with epilepsy...
June 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/26845556/a-systematic-review-of-plant-derived-natural-compounds-for-anxiety-disorders
#20
Mohammad Hosein Farzaei, Roodabeh Bahramsoltani, Roja Rahimi, Faezeh Abbasabadi, Mohammad Abdollahi
Anxiety disorders are the most common mental illnesses affecting human beings. They range from panic to generalized anxiety disorders upsetting the well-being and psychosocial performance of patients. Several conventional anxiolytic drugs are being used which in turn results in several adverse effects. Therefore, studies to find suitable safe medicines from natural sources are being conducted by researchers. The aim of the present study is to comprehensively review phytochemical compounds with well-established anxiolytic activities and their structure-activity relationships as well as neuropsychopharmacological aspects...
2016: Current Topics in Medicinal Chemistry
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