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GABA AND Supplement

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https://www.readbyqxmd.com/read/29685187/why-is-vitamin-b6-effective-in-alleviating-the-symptoms-of-autism
#1
Kohji Sato
Many factors are reported to be involved in the complex pathophysiological processes of autism, suggesting that there is considerable variability in the manifestations of this disease. Several interventions are used to treat this disorder. Among them, vitamin B6 is widely used to treat the symptoms observed in autism. Vitamin B6 is beneficial for about half of autistic individuals in decreasing behavioral problems. However, until now, it remains unknown why vitamin B6 is effective for this disease. Although the exact pathogenesis is not defined, it is evident that certain neurotransmitter systems are impaired in the brains of autistic patients, causing the symptoms observed in the disease...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29619846/lactobacillus-fermentum-hp3-mediated-fermented-hericium-erinaceus-juice-as-a-health-promoting-food-supplement-to-manage-diabetes-mellitus
#2
Chaiyavat Chaiyasut, Sasimar Woraharn, Bhagavathi Sundaram Sivamaruthi, Narissara Lailerd, Periyanaina Kesika, Sartjin Peerajan
The current study investigated the antidiabetic property of Lactobacillus fermentum HP3-mediated fermented Hericium erinaceus juice (FHJ) using male Wistar rats with streptozotocin-induced diabetes mellitus (DM). FHJ was prepared using boiled mushroom juice and L. fermentum HP3. Amino acid and γ-aminobutyric acid (GABA) content of FHJ was analyzed. Streptozotocin-induced DM rats were supplemented with FHJ in a pre- and posttreatment method. The changes in plasma insulin, plasma glucose level, glycated hemoglobin (HbA1c), representative cytokines, and the antioxidant system were assessed in experimental rats using spectrophotometric methods and enzyme-linked immunosorbent assay...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29409499/mechanisms-of-multiple-neurotransmitters-in-the-effects-of-lycopene-on-brain-injury-induced-by-hyperlipidemia
#3
Weichun Yang, Ziyi Shen, Sixian Wen, Wei Wang, Minyu Hu
BACKGROUND: Lycopene is a kind of carotenoid, with a strong capacity of antioxidation and regulating the bloodlipid. There has been some evidence that lycopene has protective effects on the central nervous system, but few studies have rigorously explored the role of neurotransmitters in it. Therefore, the present study was designed to investigate the effects of several neurotransmitters as lycopene exerts anti-injury effects induced by hyperlipidemia. METHODS: Eighty adult SD rats, half male and half female, were randomly divided into eight groups on the basis of serum total cholesterol (TC) levels and body weight...
February 7, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29389591/optimization-of-culture-conditions-for-gamma-aminobutyric-acid-production-in-fermented-adzuki-bean-milk
#4
Hung Yi Song, Roch Chui Yu
γ-Aminobutyric acid (GABA), a nonprotein amino acid, is widely distributed in nature and fulfills several physiological functions. In this study, various lactic acid strains commonly used to produce fermented milk products were inoculated into adzuki bean milk for producing GABA. The high GABA producing strain was selected in further experiment to improve the GABA production utilizing culture medium optimization. The results demonstrated that adzuki bean milk inoculated with Lactobacillus rhamnosus GG increased GABA content from 0...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29327584/gamma-aminobutyric-acid-enriched-rice-bran-diet-attenuates-insulin-resistance-and-balances-energy-expenditure-via-modification-of-gut-microbiota-and-short-chain-fatty-acids
#5
Xu Si, Wenting Shang, Zhongkai Zhou, Guanghou Shui, Sin Man Lam, Chris Blanchard, Padraig Strappe
In this study, gamma-aminobutyric acid (GABA) enriched rice bran (ERB) was supplemented to obese rats to investigate the attenuation of metabolic syndromes induced by high-fat diet. ERB-containing diet stimulated butyrate and propionate production by promoting Anaerostipes, Anaerostipes sp., and associated synthesizing enzymes. This altered short-chain fatty acid (SCFA) distribution further enhanced circulatory levels of leptin and glucagon-like peptide-1, controlling food intake by downregulating orexigenic factors...
January 31, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29315422/dietary-therapy-restores-glutamatergic-input-to-orexin-hypocretin-neurons-after-traumatic-brain-injury-in-mice
#6
Jonathan E Elliott, Samuel E De Luche, Madeline J Churchill, Cindy Moore, Akiva S Cohen, Charles K Meshul, Miranda M Lim
Study Objectives: In previous work, dietary branched-chain amino acid (BCAA) supplementation, precursors to de novo glutamate and γ-aminobutyric acid (GABA) synthesis, restored impaired sleep-wake regulation and orexin neuronal activity following traumatic brain injury (TBI) in mice. TBI was speculated to reduce orexin neuronal activity through decreased regional excitatory (glutamate) and/or increased inhibitory (GABA) input. Therefore, we hypothesized that TBI would decrease synaptic glutamate and/or increase synaptic GABA in nerve terminals contacting orexin neurons, and BCAA supplementation would restore TBI-induced changes in synaptic glutamate and/or GABA...
March 1, 2018: Sleep
https://www.readbyqxmd.com/read/29222993/supplementation-of-gamma-aminobutyric-acid-gaba-affects-temporal-but-not-spatial-visual-attention
#7
Anna Leonte, Lorenza S Colzato, Laura Steenbergen, Bernhard Hommel, Elkan G Akyürek
In a randomized, double-blind, and placebo-controlled experiment, the acute effects of gamma-aminobutyric acid (GABA) supplementation on temporal and spatial attention in young healthy adults were investigated. A hybrid two-target rapid serial visual presentation task was used to measure temporal attention and integration. Additionally, a visual search task was used to measure the speed and accuracy of spatial attention. While temporal attention depends primarily on the distribution of limited attentional resources across time, spatial attention represents the engagement and disengagement by relevant and irrelevant stimuli across the visual field...
February 2018: Brain and Cognition
https://www.readbyqxmd.com/read/29191860/hormesis-like-effect-of-mild-larval-crowding-on-thermotolerance-in-drosophila-flies
#8
Youn Henry, David Renault, Hervé Colinet
Crowding is a complex stress that can affect organisms' physiology, especially through decreased food quality and accessibility. Here, we evaluated the effect of larval density on several biological traits of Drosophila melanogaster An increasing gradient, from 1 to 1000 eggs per milliliter of food, was used to characterize life-history traits variations. Crowded conditions resulted in striking decreases of fresh mass (up to 6-fold) and viability, as well as delayed development. Next, we assessed heat and cold tolerance in L3 larvae reared at three selected larval densities: low (LD, 5 eggs ml-1 ), medium (MD, 60 eggs ml-1 ) and high (HD, 300 eggs ml-1 )...
January 29, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29175628/neuronal-death-apoptosis-induced-by-intracellular-zinc-deficiency-associated-with-changes-in-amino-acid-neurotransmitters-and-glutamate-receptor-subtypes
#9
Kun Tian, Yu-Xiang Wang, Li-Xia Li, Yan-Qiang Liu
In the present study, a model of zinc deficiency was developed by exposing primary neurons to an N,N,N',N'-Tetrakis (2-pyridylmethyl) ethylenediamine (TPEN)-containing medium. The cell survival rate, apoptosis rate, intracellular and extracellular concentrations of 4 amino acids, and the expression of 2 glutamate receptor subtypes α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (GluR2)and N-methyl-d-aspartate receptor subtype 2B (NR2B) were evaluated in zinc-deficient cells. The results revealed that zinc deficiency led to a decrease in cell viability and an increase in the apoptosis rate...
February 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29101994/acr-appropriateness-criteria%C3%A2-thoracic-aorta-interventional-planning-and-follow-up
#10
Gregory Bonci, Michael L Steigner, Michael Hanley, Aaron R Braun, Benoit Desjardins, Ron C Gaba, Kenneth L Gage, Jon S Matsumura, Eric E Roselli, David M Sella, Richard Strax, Nupur Verma, Clifford R Weiss, Karin E Dill
Thoracic endovascular aortic repair (TEVAR) has undergone rapid evolution and is now applied to a range of aortic pathologies. Imaging plays a vital role in the pre- and postintervention assessment of TEVAR patients. Accurate characterization of pathology and evaluation for high-risk anatomic features are necessary in the planning phase, and careful assessment for graft stability, aortic lumen diameter, and presence of endoleak are paramount in the follow-up period. CTA is the imaging modality of choice for pre- and postintervention assessment, and MRA is an acceptable alternative depending on patient stability and graft composition...
November 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29061647/pyridoxine-dependent-epilepsy-in-zebrafish-caused-by-aldh7a1-deficiency
#11
Izabella A Pena, Yann Roussel, Kate Daniel, Kevin Mongeon, Devon Johnstone, Hellen Weinschutz Mendes, Marjolein Bosma, Vishal Saxena, Nathalie Lepage, Pranesh Chakraborty, David A Dyment, Clara D M van Karnebeek, Nanda Verhoeven-Duif, Tuan Vu Bui, Kym M Boycott, Marc Ekker, Alex MacKenzie
Pyridoxine-dependent epilepsy (PDE) is a rare disease characterized by mutations in the lysine degradation gene ALDH7A1 leading to recurrent neonatal seizures, which are uniquely alleviated by high doses of pyridoxine or pyridoxal 5'-phosphate (vitamin B6 vitamers). Despite treatment, neurodevelopmental disabilities are still observed in most PDE patients underlining the need for adjunct therapies. Over 60 years after the initial description of PDE, we report the first animal model for this disease: an aldh7a1-null zebrafish ( Danio rerio ) displaying deficient lysine metabolism and spontaneous and recurrent seizures in the larval stage (10 days postfertilization)...
December 2017: Genetics
https://www.readbyqxmd.com/read/28918494/betaine-in-the-brain-characterization-of-betaine-uptake-its-influence-on-other-osmolytes-and-its-potential-role-in-neuroprotection-from-osmotic-stress
#12
Leena S Knight, Quinn Piibe, Ian Lambie, Christopher Perkins, Paul H Yancey
Betaine (N-trimethylglycine), a common osmolyte, has received attention because of the number of clinical reports associating betaine supplementation with improved cognition, neuroprotection and exercise physiology. However, tissue analyses report little accumulation of betaine in brain tissue despite the presence of betaine/GABA transporters (BGT1) at the blood brain barrier and in nervous tissue, calling into question whether betaine influences neuronal function directly or indirectly. Therefore, the focus of this study was to determine what capacity nervous tissue has to accumulate betaine, specifically in the hippocampus, a region of the brain associated with learning and memory and one that is particularly susceptible to damage (e...
December 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28911262/alleviation-by-gamma-amino-butyric-acid-supplementation-of-chronic-heat-stress-induced-degenerative-changes-in-jejunum-in-commercial-broiler-chickens
#13
Rasha A Al Wakeel, Mustafa Shukry, Ahmed Abdel Azeez, Shawky Mahmoud, Michel Fahmy Saad
High ambient temperature adversely influences poultry production. In the present study, gamma amino butyric acid (GABA) supplementation was used to alleviate the adverse changes due to heat stress (HS) in a broiler chicken strain (Ross 308). At 21 days of age, the birds were divided into four groups of 13. Two groups were housed under normal room temperature, one group was given orally 0.2 ml 0.9% physiological saline (CN) daily, the other group received 0.2 ml of 0.5% GABA solution orally (GN). A third group was exposed to environmental HS (33 ± 1 °C lasting for 2 weeks) + physiological saline (CH) and a fourth group was exposed to HS + GABA supplementation (GH)...
November 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28702122/gaba-signaling-stimulates-%C3%AE-cell-mediated-%C3%AE-like-cell-neogenesis
#14
Tiziana Napolitano, Fabio Avolio, Andhira Vieira, Nouha Ben-Othman, Monica Courtney, Elisabet Gjernes, Biljana Hadzic, Noémie Druelle, Sergi Navarro Sanz, Serena Silvano, Ahmed Mansouri, Patrick Collombat
Diabetes is a chronic and progressing disease, the number of patients increasing exponentially, especially in industrialized countries. Regenerating lost insulin-producing cells would represent a promising therapeutic alternative for most diabetic patients. To this end, using the mouse as a model, we reported that GABA, a food supplement, could induce insulin-producing beta-like cell neogenesis offering an attractive and innovative approach for diabetes therapeutics.
2017: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/28697461/direct-induction-of-functional-neuronal-cells-from-fibroblast-like-cells-derived-from-adult-human-retina
#15
Lili Hao, Zhen Xu, Hui Sun, Wu Luo, Youchen Yan, Jing Wang, Jingyi Guo, Yizhi Liu, Shuyi Chen
Obtaining and manipulating neuronal cells are critical for neural biology basic mechanism studies and translational applications. Recent advances in protocol development and mechanism dissections have made direct induction of neuronal cells from other somatic cells (iN) a promising strategy for such purposes. In this study, we established a protocol to expand a population of fibroblast-like cells from adult human retinal tissues, which can be reprogrammed into iNs by forced expression of neurogenic transcription factors...
August 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28687488/rescuing-fluoride-induced-damages-in-liver-with-gamma-aminobutyric-acid
#16
Haoyue Yang, Ronge Xing, Song Liu, Huahua Yu, Pengcheng Li
Fluorine poisoning affects human health all over the world and an urgent task is to develop alleviative medicine to recover or ameliorate the damages to the body. Here we studied the effects of gamma-aminobutyric acid (GABA), a liver protector reported previously, on fluoride-induced damage in the mouse liver. Through microscope imaging of the liver tissue, TUNEL immunostaining, real-time RT-PCR, enzyme immunoassay and colorimetric method, we found that GABA supplementation prevented the metabolic toxicity caused by fluoride treatment in mice...
September 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28655701/impact-of-oral-supplementation-of-glutamate-and-gaba-on-memory-performance-and-neurochemical-profile-in-hippocampus-of-rats
#17
Saiqa Tabassum, Saara Ahmad, Syeda Madiha, Saima Khaliq, Sidrah Shahzad, Zehra Batool, Saida Haider
Glutamate (GLU) and gamma-amino butyric acid (GABA) are essential amino acids (AA) for brain function serving as excitatory and inhibitory neurotransmitter respectively. Their tablets are available in market for improving gut function and muscle performance. Despite of having a major role during memory formation and processing, effects of these tablets on brain functioning like learning and memory have not been investigated. Therefore, present study is aimed to investigate the effects of orally supplemented GLU and GABA on learning and memory performance and further to monitor related effects of these orally supplemented GLU and GABA on brain levels of these AA...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28651118/magnesium-in-schizophrenia
#18
REVIEW
Michal Ordak, Joanna Matras, Elzbieta Muszynska, Tadeusz Nasierowski, Magdalena Bujalska-Zadrozny
Many psychopathological symptoms, including schizophrenia, can be associated with magnesium metabolism disturbances. In the literature, contradictory data exist regarding magnesium levels in patients with this disorder. However, this situation might be caused by determination of extracellular concentration of magnesium; although, this is mainly an intracellular ion. There are no data concerning determination of the ionized fraction of magnesium in patients with schizophrenia, while the ionized fraction represents 67% of the total pool of magnesium in healthy people...
April 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28641214/motor-system-dysfunction-in-the-schizophrenia-diathesis-neural-systems-to-neurotransmitters
#19
REVIEW
R Abboud, C Noronha, V A Diwadkar
Motor control is a ubiquitous aspect of human function, and from its earliest origins, abnormal motor control has been proposed as being central to schizophrenia. The neurobiological architecture of the motor system is well understood in primates and involves cortical and sub-cortical components including the primary motor cortex, supplementary motor area, dorsal anterior cingulate cortex, the prefrontal cortex, the basal ganglia, and cerebellum. Notably all of these regions are associated in some manner to the pathophysiology of schizophrenia...
July 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28517911/is-there-a-potential-of-misuse-for-magnolia-officinalis-compounds-metabolites
#20
Fabrizio Schifano, Valentina Guarino, Duccio G Papanti, Jacopo Baccarin, Laura Orsolini, John M Corkery
OBJECTIVE: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers. METHODS: A literature review, assessment of related anecdotal online Magnolia misuse's reports and an overview of Magnolia products' online acquisition possibilities has been here described. RESULTS: No peer-reviewed papers about Magnolia abuse/misuse/dependence/addiction were identified...
May 18, 2017: Human Psychopharmacology
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