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GABA AND Supplement

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https://www.readbyqxmd.com/read/28212288/the-search-for-dietary-supplements-to-elevate-or-activate-circulating-paraoxonases
#1
REVIEW
José M Lou-Bonafonte, Clara Gabás-Rivera, María A Navarro, Jesús Osada
Low levels of paraoxonase 1 (PON1) have been associated with the development of several pathological conditions, whereas high levels have been shown to be anti-atherosclerotic in mouse models. These findings suggest that PON1 could be a good surrogate biomarker. The other members of the family, namely PON2 and PON3, the role of which has been much less studied, deserve more attention. This paper provides a systematic review of current evidence concerning dietary supplements in that regard. Preliminary studies indicate that the response to dietary supplements may have a nutrigenetic aspect that will need to be considered in large population studies or in clinical trials...
February 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28036014/germinated-thai-black-rice-extract-protects-experimental-diabetic-rats-from-oxidative-stress-and-other-diabetes-related-consequences
#2
Chaiyavat Chaiyasut, Bhagavathi Sundaram Sivamaruthi, Noppawat Pengkumsri, Waranya Keapai, Periyanaina Kesika, Manee Saelee, Parichart Tojing, Sasithorn Sirilun, Khontaros Chaiyasut, Sartjin Peerajan, Narissara Lailerd
Background: Diabetes mellitus (DM), particularly type 2 DM (T2DM), is one of the most common metabolic disorder worldwide. The prevention measures and treatment strategies for DM are improving steadily. The current study explains the impact of germination on phytochemical content of Thai black rice (BR), and the influence of germinated BR extract (GBRE) supplementation on diabetic conditions in rats. Methods: BR was germinated and the phenolic, anthocyanin, and γ-aminobutyric acid (GABA) content of the extract were analyzed using HPLC and spectrophotometric methods...
December 28, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/28032215/a-driver-role-for-gaba-metabolism-in-controlling-stem-and-proliferative-cell-state-through-ghb-production-in-glioma
#3
Elias A El-Habr, Luiz G Dubois, Fanny Burel-Vandenbos, Alexandra Bogeas, Joanna Lipecka, Laurent Turchi, François-Xavier Lejeune, Paulo Lucas Cerqueira Coehlo, Tomohiro Yamaki, Bryan M Wittmann, Mohamed Fareh, Emna Mahfoudhi, Maxime Janin, Ashwin Narayanan, Ghislaine Morvan-Dubois, Charlotte Schmitt, Maité Verreault, Lisa Oliver, Ariane Sharif, Johan Pallud, Bertrand Devaux, Stéphanie Puget, Penelope Korkolopoulou, Pascale Varlet, Chris Ottolenghi, Isabelle Plo, Vivaldo Moura-Neto, Thierry Virolle, Hervé Chneiweiss, Marie-Pierre Junier
Cell populations with differing proliferative, stem-like and tumorigenic states co-exist in most tumors and especially malignant gliomas. Whether metabolic variations can drive this heterogeneity by controlling dynamic changes in cell states is unknown. Metabolite profiling of human adult glioblastoma stem-like cells upon loss of their tumorigenicity revealed a switch in the catabolism of the GABA neurotransmitter toward enhanced production and secretion of its by-product GHB (4-hydroxybutyrate). This switch was driven by succinic semialdehyde dehydrogenase (SSADH) downregulation...
December 28, 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27965654/the-neuro-endocrinological-role-of-microbial-glutamate-and-gaba-signaling
#4
REVIEW
Roberto Mazzoli, Enrica Pessione
Gut microbiota provides the host with multiple functions (e.g., by contributing to food digestion, vitamin supplementation, and defense against pathogenic strains) and interacts with the host organism through both direct contact (e.g., through surface antigens) and soluble molecules, which are produced by the microbial metabolism. The existence of the so-called gut-brain axis of bi-directional communication between the gastrointestinal tract and the central nervous system (CNS) also supports a communication pathway between the gut microbiota and neural circuits of the host, including the CNS...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27923157/adjuvant-neuronal-nitric-oxide-synthase-inhibition-for-combined-treatment-of-epilepsy-and-comorbid-depression
#5
Tanveer Singh, Rajesh Kumar Goel
BACKGROUND: Elevated nitric oxide (NO) levels in the brain have been apparently associated with depression in kindled animals. Owing to the major role of neuronal nitric oxide synthase (nNOS) in brain and ineffectiveness of antiepileptic drugs (AEDs) in restoring nitrosative stress, the present study was envisaged to evaluate the adjuvant nNOS inhibitor, 7-nitroindazole (7-NI) with valproic acid for combined treatment of epilepsy and associated depression. METHODS: Pentylenetetrazole kindled animals associated with depression were treated with vehicle, valproate (300mg/kg/day ip), valproate with 7-NI (10mg/kg; 20mg/kg; 40mg/kg)/day ip and 7-NI (40mg/kg/day ip) for 15days...
February 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27920772/streptococcus-thermophilus-apc151-strain-is-suitable-for-the-manufacture-of-naturally-gaba-enriched-bioactive-yogurt
#6
Daniel M Linares, Tom F O'Callaghan, Paula M O'Connor, R P Ross, Catherine Stanton
Consumer interest in health-promoting food products is a major driving force for the increasing global demand of functional (probiotic) dairy foods. Yogurt is considered the ideal medium for delivery of beneficial functional ingredients. Gamma-amino-butyric acid has potential as a bioactive ingredient in functional foods due to its health-promoting properties as an anti-stress, anti-hypertensive, and anti-diabetic agent. Here, we report the use of a novel Streptococcus thermophilus strain, isolated from the digestive tract of fish, for production of yogurt naturally enriched with 2 mg/ml of gamma-amino-butyric acid (200 mg in a standard yogurt volume of 100 ml), a dose in the same range as that provided by some commercially available gamma-amino-butyric acid supplements...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27808555/randomized-open-label-trial-of-baclofen-for-relapse-prevention-in-alcohol-dependence
#7
Manushree Gupta, Pankaj Verma, Rajesh Rastogi, Sheetal Arora, Deeksha Elwadhi
BACKGROUND: Alcohol dependence is a progressive chronic disorder characterized by narrowing of the drinking repertoire, salience of drinking, tolerance and withdrawal phenomenon, compulsion to drink, and frequent relapses. Baclofen has been shown to promote abstinence, to reduce craving, and to reduce anxiety in alcohol-dependent individuals, and it promises to be a useful agent, although clinical data are limited at present. OBJECTIVE: The current study aimed to test the utility of baclofen, a GABA agonist, in improving the relapse rates in alcohol-dependent subjects...
November 3, 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/27790703/the-effect-of-fermented-buckwheat-on-producing-l-carnitine-and-gamma-aminobutyric-acid-gaba-enriched-designer-eggs
#8
Namhyeon Park, Tae-Kyung Lee, Thi Thanh Hanh Nguyen, Eun-Bae An, Nahyun M Kim, Young-Hyun You, Tae-Sub Park, Doman Kim
BACKGROUND: The potential of fermented buckwheat as feed additives was studied to increase L-carnitine and gamma-aminobutyric acid (GABA) in designer eggs. Buckwheat contains high levels of lysine, methionine, and glutamate, which are precursors for the synthesis of L-carnitine and GABA. Rhizopus oligosporus was used for the fermentation of buckwheat to produce L-carnitine and GABA that exert positive effects like enhanced metabolism, antioxidant activities, immunity, and blood pressure control...
October 28, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27657037/the-anticonvulsant-activity-of-a-flavonoid-rich-extract-from-orange-juice-involves-both-nmda-and-gaba-benzodiazepine-receptor-complexes
#9
Rita Citraro, Michele Navarra, Antonio Leo, Eugenio Donato Di Paola, Ermenegildo Santangelo, Pellegrino Lippiello, Rossana Aiello, Emilio Russo, Giovambattista De Sarro
The usage of dietary supplements and other natural products to treat neurological diseases has been growing over time, and accumulating evidence suggests that flavonoids possess anticonvulsant properties. The aim of this study was to examine the effects of a flavonoid-rich extract from orange juice (OJe) in some rodent models of epilepsy and to explore its possible mechanism of action. The genetically audiogenic seizures (AGS)-susceptible DBA/2 mouse, the pentylenetetrazole (PTZ)-induced seizures in ICR-CD1 mice and the WAG/Rij rat as a genetic model of absence epilepsy with comorbidity of depression were used...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27628921/ameliorative-effect-of-synthetic-%C3%AE-aminobutyric-acid-gaba-on-performance-traits-antioxidant-status-and-immune-response-in-broiler-exposed-to-cyclic-heat-stress
#10
Naila Chand, Sher Muhammad, Rifat Ullah Khan, Ibrahim Abdullah Alhidary, Zia Ur Rehman
The aim of this study was to find the effect of synthetic γ-aminobutyric acid (GABA) on the performance, antioxidant status, and immune response in broiler exposed to summer stress. A total of 400-day-old male broiler chickens (Ross 308) was randomly distributed into five treatments (5 replicates). One group served as a control (basal diet only) while the others were supplemented with GABA at the rate of 25 (GABA-25), 50 (GABA 50), 75 (GABA-75), and 100 (GABA-100) mg/kg feed. The experiment was continued for 35 days...
December 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27621692/effects-of-germinated-brown-rice-addition-on-the-flavor-and-functionality-of-yogurt
#11
Mi-Hye Kim, Sung-Il Ahn, Chan-Mook Lim, Jin-Woo Jhoo, Gur-Yoo Kim
This study aimed to investigate the functional and physicochemical properties of yogurt, supplemented with germinated brown rice (GBR) containing γ-aminobutyric acid (GABA), during storage. GBR was produced by soaking brown rice at 30℃, and saccharified germinated brown rice (SGBR) was produced by treating brown rice with α- and β-amylase for 1 h, at 80℃ and 60℃, respectively. Yogurt was manufactured using a commercial starter (YC-X11, CHR. Hansen, Denmark) at 37℃ for 12 h. The fatty acids and GABA contents were analyzed using GC and HPLC, respectively...
2016: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/27479478/nonpharmacological-alternatives-to-benzodiazepine-drugs-for-the-treatment-of-anxiety-in-outpatient-populations-a-literature-review
#12
Lois M Platt, Amy Irene Whitburn, Alexander G Platt-Koch, Ronald L Koch
Overuse of benzodiazepine drugs to treat anxiety, mood, and sleep disorders is a growing problem in clinical practice. GABAergic medications (benzodiazepine drugs in particular) have side effects, drug interactions, and the potential to create tolerance and dependence in users. GABA-enhancing dietary supplements have similar and unique risks. Natural, non-chemical, anxiolytic treatments exist and can be safely recommended to patients. Three such treatments have been the focus of study in the past 20 years: mindfulness, meditation, and yoga...
August 1, 2016: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/27458444/gaba-production-in-lactococcus-lactis-is-enhanced-by-arginine-and-co-addition-of-malate
#13
Valérie Laroute, Chonthicha Yasaro, Waranya Narin, Roberto Mazzoli, Enrica Pessione, Muriel Cocaign-Bousquet, Pascal Loubière
Lactococcus lactis NCDO 2118 was previously selected for its ability to decarboxylate glutamate to γ-aminobutyric acid (GABA), an interesting nutritional supplement able to improve mood and relaxation. Amino acid decarboxylation is generally considered as among the biochemical systems allowing lactic acid bacteria to counteracting acidic stress and obtaining metabolic energy. These strategies also include arginine deiminase pathway and malolactic fermentation but little is known about their possible interactions of with GABA production...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27438707/pyridoxine-supplementation-improves-the-activity-of-recombinant-glutamate-decarboxylase-and-the-enzymatic-production-of-gama-aminobutyric-acid
#14
Yan Huang, Lingqia Su, Jing Wu
Glutamate decarboxylase (GAD) catalyzes the irreversible decarboxylation of L-glutamate to the valuable food supplement γ-aminobutyric acid (GABA). In this study, GAD from Escherichia coli K12, a pyridoxal phosphate (PLP)-dependent enzyme, was overexpressed in E. coli. The GAD produced in media supplemented with 0.05 mM soluble vitamin B6 analog pyridoxine hydrochloride (GAD-V) activity was 154.8 U mL-1, 1.8-fold higher than that of GAD obtained without supplementation (GAD-C). Purified GAD-V exhibited increased activity (193...
2016: PloS One
https://www.readbyqxmd.com/read/27281617/prevention-of-pancreatic-cancer-in-a-hamster-model-by-camp-decrease
#15
Jheelam Banerjee, Arokya M S Papu John, Mohammed H Al-Wadei, Hildegard M Schuller
Smoking and alcoholism are risk factors for the development of pancreatitis-associated pancreatic ductal adenocarcinoma (PDAC). We have previously shown that these cancers overexpressed stress neurotransmitters and cyclic adenosine monophosphate (cAMP) while the inhibitory neurotransmitter γ-aminobutyric acid (GABA) was suppressed. Using a hamster model, the current study has tested the hypothesis that cAMP decrease by GABA supplementation in the drinking water prevents the development of pancreatitis-associated PDAC...
July 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27176157/remote-prenatal-care-monitoring-with-digital-health-tools-can-reduce-visit-frequency-while-improving-satisfaction-3
#16
Kathryn I Marko, Nihar Ganju, James Brown, Joshua Benham, Nancy D Gaba
INTRODUCTION: A high frequency of in-clinic visits is standard for prenatal surveillance. Yet in studies, reduction in prenatal care visits is not correlated with adverse perinatal outcomes for low-risk pregnancies. However, it is associated with decreased patient satisfaction. This study sought to measure the effect of reducing the frequency of prenatal visits while applying mobile/digital health technology for improved patient satisfaction and equivalent outcomes in low-risk pregnancies...
May 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27161372/the-influence-of-manganese-and-glutamine-intake-on-antioxidants-and-neurotransmitter-amino-acids-levels-in-rats-brain
#17
Maria Szpetnar, Dorota Luchowska-Kocot, Anna Boguszewska-Czubara, Jacek Kurzepa
Depending on the concentration, Mn can exert protective or toxic effect. Potential mechanism for manganese neurotoxicity is manganese-induced oxidative stress. Glutamine supplementation could reduce manganese-induced neurotoxicity and is able to influence the neurotransmission processes. The aim of this study was to investigate whether the long term administration of manganese (alone or in combination with glutamine) in dose and time dependent manner could affect the selected parameters of oxidative-antioxidative status (superoxide dismutase and glutathione peroxidase activities, concentrations of vitamin C and malonic dialdehyde) and concentrations of excitatory (Asp, Glu) and inhibitory amino acids (GABA, Gly) in the brain of rats...
August 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27153397/mechanisms-and-disease-associations-of-haplotype-dependent-allele-specific-dna-methylation
#18
Catherine Do, Charles F Lang, John Lin, Huferesh Darbary, Izabela Krupska, Aulona Gaba, Lynn Petukhova, Jean-Paul Vonsattel, Mary P Gallagher, Robin S Goland, Raphael A Clynes, Andrew Dwork, John G Kral, Catherine Monk, Angela M Christiano, Benjamin Tycko
Haplotype-dependent allele-specific methylation (hap-ASM) can impact disease susceptibility, but maps of this phenomenon using stringent criteria in disease-relevant tissues remain sparse. Here we apply array-based and Methyl-Seq approaches to multiple human tissues and cell types, including brain, purified neurons and glia, T lymphocytes, and placenta, and identify 795 hap-ASM differentially methylated regions (DMRs) and 3,082 strong methylation quantitative trait loci (mQTLs), most not previously reported...
May 5, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27129463/the-effects-of-creatine-supplementation-on-striatal-neural-progenitor-cells-depend-on-developmental-stage
#19
Robert H Andres, Angelique D Ducray, Lukas Andereggen, Tabea Hohl, Uwe Schlattner, Theo Wallimann, Hans R Widmer
Transplantation of neural progenitor cells (NPCs) is a promising experimental therapy for Huntington's disease (HD). The variables responsible for the success of this approach, including selection of the optimal developmental stage of the grafted cells, are however largely unknown. Supporting cellular energy metabolism by creatine (Cr) supplementation is a clinically translatable method for improving cell transplantation strategies. The present study aims at investigating differences between early (E14) and late (E18) developmental stages of rat striatal NPCs in vitro...
August 2016: Amino Acids
https://www.readbyqxmd.com/read/27062388/carnosine-and-anserine-homeostasis-in-skeletal-muscle-and-heart-is-controlled-by-%C3%AE-alanine-transamination
#20
Laura Blancquaert, Shahid P Baba, Sebastian Kwiatkowski, Jan Stautemas, Sanne Stegen, Silvia Barbaresi, Weiliang Chung, Adjoa A Boakye, J David Hoetker, Aruni Bhatnagar, Joris Delanghe, Bert Vanheel, Maria Veiga-da-Cunha, Wim Derave, Inge Everaert
KEY POINTS: Using recombinant DNA technology, the present study provides the first strong and direct evidence indicating that β-alanine is an efficient substrate for the mammalian transaminating enzymes 4-aminobutyrate-2-oxoglutarate transaminase and alanine-glyoxylate transaminase. The concentration of carnosine and anserine in murine skeletal and heart muscle depends on circulating availability of β-alanine, which is in turn controlled by degradation of β-alanine in liver and kidney...
September 1, 2016: Journal of Physiology
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