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GABA AND Oral

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https://www.readbyqxmd.com/read/28292021/antinociceptive-pharmacological-profile-of-dysphania-graveolens-in-mouse
#1
Myrna Déciga-Campos, Rachel Mata, Isabel Rivero-Cruz
This work evaluates the potential antinociceptive activity of Dysphania graveolens, traditional medicinal plant used in Mexico to treat stomach pain. A CH2Cl2-MeOH extract, infusion and essential oil from aerial parts of Dysphania graveolens were evaluated in hot plate and writhing tests in mice. The metabolites pinostrobin, pinocembrin and chrysin were isolated from the Dysphania graveolens infusion; next, they were evaluated in both nociceptive tests. To confirm the antinociceptive activity and explore the possible participation of opioid, GABA and serotonin receptors in the pharmacological mechanism, a formalin test was used...
March 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28224477/genistein-alleviates-neuroinflammation-and-restores-cognitive-function-in-rat-model-of-hepatic-encephalopathy-underlying-mechanisms
#2
Ajaz Ahmad Ganai, Mohammad Husain
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome resulting from acute liver failure. Previously, we demonstrated hepatoprotective effects of genistein in D-galactosamine (D-GalN)-induced fulminant hepatic failure (FHF). In this study, we evaluated behavioural and neuroprotective effects of genistein in rat model of HE. HE was induced by intraperitonial administration of D-GalN (250 mg/kg BW) twice a week for 30 days Genistein was given as co-treatment through oral gavage daily at dose of 5 mg/kg BW...
February 21, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28192622/the-safety-and-efficacy-of-baclofen-to-reduce-alcohol-use-in-veterans-with-chronic-hepatitis-c-a-randomized-clinical-trial
#3
Peter Hauser, Bret Fuller, Samuel B Ho, Paul Thuras, Shira Kern, Eric Dieperink
BACKGROUND AND AIMS: Alcohol use disorders (AUDs) are common among people with chronic hepatitis C (HCV) and accelerate the development of fibrosis and cirrhosis caused by HCV. Baclofen, a gamma-aminobutyric acid (GABA) beta-receptor agonist, differs from medications for AUDs currently approved by the United States (US) Federal Drug Administration (FDA) as it is metabolized primarily through the kidneys. The primary outcome of this study was to compare baclofen with a placebo in the percentage of days abstinent from alcohol...
February 13, 2017: Addiction
https://www.readbyqxmd.com/read/28165823/nanocarriers-as-treatment-modalities-for-hypertension
#4
Tausif Alam, Saba Khan, Bharti Gaba, Md Faheem Haider, Sanjula Baboota, Javed Ali
Hypertension, a worldwide epidemic at present, is not a disease in itself rather it is an important risk factor for serious cardiovascular disorders including myocardial infarction, stroke, heart failure, and peripheral artery disease. Though numerous drugs acting via different mechanism of action are available in the market as conventional formulations for the treatment of hypertension but they face substantial challenges regarding their bioavailability, dosing and associated adverse effects which greatly limit their therapeutic efficacies...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28125677/prophylactic-versus-therapeutic-fingolimod-restoration-of-presynaptic-defects-in-mice-suffering-from-experimental-autoimmune-encephalomyelitis
#5
Tommaso Bonfiglio, Guendalina Olivero, Elisa Merega, Silvia Di Prisco, Cristina Padolecchia, Massimo Grilli, Marco Milanese, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Giambattista Bonanno, Mario Marchi, Anna Pittaluga
Fingolimod, the first oral, disease-modifying therapy for MS, has been recently proposed to modulate glutamate transmission in the central nervous system (CNS) of mice suffering from Experimental Autoimmune Encephalomyelitis (EAE) and in MS patients. Our study aims at investigating whether oral fingolimod recovers presynaptic defects that occur at different stages of disease in the CNS of EAE mice. In vivo prophylactic (0.3 mg/kg for 14 days, from the 7th day post immunization, d.p.i, the drug dissolved in the drinking water) fingolimod significantly reduced the clinical symptoms and the anxiety-related behaviour in EAE mice...
2017: PloS One
https://www.readbyqxmd.com/read/28067943/gamma-aminobutyric-acid-gaba-modulators-for-amyotrophic-lateral-sclerosis-motor-neuron-disease
#6
REVIEW
Andrea Diana, Rita Pillai, Paolo Bongioanni, Aidan G O'Keeffe, Robert G Miller, Dan H Moore
BACKGROUND: Imbalance of gamma aminobutyric acid (GABA) and related modulators has been implicated as an important factor in the pathogenesis of amyotrophic lateral sclerosis (ALS), which is also known as motor neuron disease (MND). In this context, the role and mechanism of action of gabapentin and baclofen have been extensively investigated, although with conflicting results. This is the first systematic review to assess clinical trials of GABA modulators for the treatment of ALS. OBJECTIVES: To examine the efficacy of gabapentin, baclofen, or other GABA modulators in delaying the progression of ALS, and to evaluate adverse effects of these interventions SEARCH METHODS: On 16 August 2016, we searched the Cochrane Neuromuscular Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL Plus, AMED, and LILACS...
January 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27974891/impact-of-exposure-to-fenitrothion-on-vital-organs-in-rats
#7
Rasha Abdel-Ghany, Ebaa Mohammed, Shimaa Anis, Waleed Barakat
This study was designed to investigate the impact of oral administration of fenitrothion (10 mg/kg) on liver, kidney, brain, and lung function in rats. The effect was studied on days 7, 14, 21, 28, and 42. Our results have shown deterioration in liver function as evidenced by the elevation in serum ALT, AST, ALP, and bilirubin and reduction in albumin and hepatic glycogen. This was associated with a state of hyperglycemia and hyperlipidemia and increased prothrombin time, while hemoglobin content was reduced...
2016: Journal of Toxicology
https://www.readbyqxmd.com/read/27971081/market-uptake-of-direct-oral-anticoagulants-doacs-in-germany
#8
A Batscheider, S Dannemann, D Gaba, G Paulus, B Antoni, P Stoecker, B Greese, R Greiner
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27927951/effects-of-the-selective-%C3%AE-5-gabaar-antagonist-s44819-on-excitability-in-the-human-brain-a-tms-emg-and-tms-eeg-phase-i-study
#9
Ghazaleh Darmani, Carl M Zipser, Gabriele M Böhmer, Karine Deschet, Florian Müller-Dahlhaus, Paolo Belardinelli, Matthias Schwab, Ulf Ziemann
Alpha-5 gamma-aminobutyric acid type A receptors (α5-GABAARs) are located extrasynaptically, regulate neuronal excitability through tonic inhibition, and are fundamentally important for processes such as plasticity and learning. For example, pharmacological blockade of α5-GABAAR in mice with ischemic stroke improved recovery of function by normalizing exaggerated perilesional α5-GABAAR-dependent tonic inhibition. S44819 is a novel competitive selective antagonist of the α5-GABAAR at the GABA-binding site...
December 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27853890/neuroprotective-potential-of-curcumin-in-combination-with-piperine-against-6-hydroxy-dopamine-induced-motor-deficit-and-neurochemical-alterations-in-rats
#10
Shamsher Singh, Puneet Kumar
AIM AND OBJECTIVE: 6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine-induced Parkinsonian rats was used to investigate the antioxidant, neuromodulatory and neuroprotective mechanisms. MATERIALS AND METHODS: Hemi-Parkinson's rat model was developed with intranigral infusion of 6-OHDA (8 μg/2 μl, once, unilaterally), treatment with CMN (25 and 50 mg/kg) and combination of PP (2...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/27773905/a-case-of-relapsing-encephalitis-positive-for-gamma-aminobutyric-acid-gaba-a-receptor-antibody-associated-with-type-b3-thymoma
#11
Takaya Kitano, Makoto Kinoshita, Kohki Shimazu, Hiroaki Fushimi, Kenichi Omori, Takanori Hazama
A 87-year-old female presented with subacute progression of cognitive decline. Fluid-attenuated inversion recovery images of brain MRI showed multifocal high-intensity lesions. Thoracic CT image revealed the presence of thymoma, and serum autoantibody screening showed positivity for anti-gamma aminobutyric acid (GABA)A receptor antibody. Histopathological analysis confirmed type B3 thymoma after thymectomy. The patient received both plasmapheresis and intravenous methylprednisolone therapy, and showed remarkable amelioration of clinical symptoms and MRI abnormal high intensity...
November 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27760889/g-aminobutyric-acid-promotes-methionine-choline-deficient-diet-induced-nonalcoholic-steatohepatitis
#12
Seok Roh Yoon, Cho Ara, Zhou Zixiong, Jeong Hyuneui, Park Jeong-Eun, Cha Youn-Soo, Oh Suk-Heung, Lim Chae-Woong, Kim Bumseok
Nonalcoholic steatohepatitis (NASH) is one of the most common liver diseases and a major cause of liver fibrosis worldwide. G-Aminobutyric acid (GABA) is one of the most abundant inhibitory neurotransmitters in the central nervous system. Recently, it has been reported that GABAergic signaling pathways are found in various non-neuronal tissues including the immune system and play a functional role. In the present study, we investigated whether administration of GABA has effects on NASH through its immunomodulatory effects...
October 17, 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27695258/in-vivo-study-on-depressant-effects-and-muscle-coordination-activity-of-galphimia-glauca-stem-methanol-extract
#13
Baba Shankar Rao Garige, Srisailam Keshetti, Uma Maheshwara Rao Vattikuti
BACKGROUND: Galphimia glauca is an evergreen shrub found across peninsular India, belonging to family Malpighiaceae. OBJECTIVE: The objective of this study was to assess the in vivo depressant effects and muscle coordination activity of G. glauca stem methanol extract (GGSME). MATERIALS AND METHODS: The stem methanol extract was administered in Swiss albino mice in 1 day to study the central nervous system (CNS) depressant and muscle coordination activity employing animal models such as sodium pentobarbital-induced sleep test, hole-board test, open field test, pentylenetetrazole (PTZ)-induced convulsions, picrotoxin-induced convulsions, grip strengthening test in mice, and Rota-rod test...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27630927/effect-of-oral-pregabalin-as-preemptive-analgesic-in-patients-undergoing-lower-limb-orthopedic-surgeries-under-spinal-anaesthesia
#14
Bon Sebastian, Anand Tippanna Talikoti, Kiran Nelamangala, Dinesh Krishnamurthy
INTRODUCTION: Conquering postoperative pain which has significant impact on the surgery outcome can be challenging for the clinicians. Pregabalin is a GABA analogue used for various neuropathic pain syndromes. Very few studies are there with the use of pregabalin as a preemptive analgesic for orthopedic surgeries. AIM: To compare pregabalin 150 mg with placebo for postoperative pain control in patients undergoing elective lower limb orthopedic surgeries under spinal anaesthesia and to assess any side effects...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27458085/gaba-producing-bifidobacterium-dentium-modulates-visceral-sensitivity-in-the-intestine
#15
K Pokusaeva, C Johnson, B Luk, G Uribe, Y Fu, N Oezguen, R K Matsunami, M Lugo, A Major, Y Mori-Akiyama, E B Hollister, S M Dann, X Z Shi, D A Engler, T Savidge, J Versalovic
BACKGROUND: Recurrent abdominal pain is a common and costly health-care problem attributed, in part, to visceral hypersensitivity. Increasing evidence suggests that gut bacteria contribute to abdominal pain perception by modulating the microbiome-gut-brain axis. However, specific microbial signals remain poorly defined. γ-aminobutyric acid (GABA) is a principal inhibitory neurotransmitter and a key regulator of abdominal and central pain perception from peripheral afferent neurons. Although gut bacteria are reported to produce GABA, it is not known whether the microbial-derived neurotransmitter modulates abdominal pain...
January 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27452860/oral-coq10-attenuates-high-salt-induced-hypertension-by-restoring-neurotransmitters-and-cytokines-in-the-hypothalamic-paraventricular-nucleus
#16
Hong-Li Gao, Xiao-Jing Yu, Jie Qi, Qiu-Yue Yi, Wang-Hui Jing, Wen-Yan Sun, Wei Cui, Jian-Jun Mu, Zu-Yi Yuan, Xiu-Fang Zhao, Kai-Li Liu, Guo-Qing Zhu, Xiao-Lian Shi, Jin-Jun Liu, Yu-Ming Kang
High salt intake leads to an increase in some proinflammatory cytokines and neurotransmitters involved in the pathogenesis of hypertension. The purpose of this work was to know if oral administration of anti-oxidant and free-radical scavenger CoQ10 may attenuate high salt-induced hypertension via regulating neurotransmitters and cytokines in the hypothalamic paraventricular nucleus (PVN). Adult male Sprague-Dawley (SD) rats were fed with a normal salt diet (NS, 0.3% NaCl) or a high salt diet (HS, 8% NaCl) for 15 weeks to induce hypertension...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27359496/combined-oral-intake-of-gaba-with-whey-protein-improves-lean-mass-in-resistance-trained-men-241-board-78-june-1-9-30-am-11-00-am
#17
Maya Sakashita, Utano Nakamura, Isafumi Maru, Seiyu Harada, Jeong Won Kim, Noriko Horie, Mujo Kim, Yasuhiro Yokoyama, Satoshi Fujita
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27313654/immunohistochemical-and-ultrastructural-properties-of-the-larval-ciliary-band-associated-strand-in-the-sea-urchin-hemicentrotus-pulcherrimus
#18
Hideki Katow, Tomoko Katow, Hiromi Yoshida, Masato Kiyomoto, Isao Uemura
BACKGROUND: The swimming activity of sea urchin larvae is dependent on the ciliary band (CB) on the larval surface and is regulated by several neurotransmitters, including serotonin (5HT), dopamine, and γ-aminobutyric acid (GABA). However, the CB signal transmission mechanism remains unknown. The present study investigated the structural relationship between the CB and external signal receptors by immunohistochemical and transmission electron microscopic analyses of sea urchin, Hemicentrotus pulcherrimus, larvae...
2016: Frontiers in Zoology
https://www.readbyqxmd.com/read/27291136/gastroprotective-effect-of-myrtenol-against-ethanol-induced-acute-gastric-lesions-possible-mechanisms
#19
Ana Flávia Seraine Custódio Viana, Francilene Vieira da Silva, Hélio de Barros Fernandes, Irisdalva Sousa Oliveira, Milena Aguiar Braga, Paulo Iury Gomes Nunes, Daniel de Araújo Viana, Damião Pergentino de Sousa, Vietla Satyanarayana Rao, Rita de Cássia Meneses Oliveira, Flávia Almeida Santos
OBJECTIVES: (-)-Myrtenol is a natural fragrance monoterpenoid structurally related to α-pinene found in diverse plant essential oils. This study was aimed to assess the anti-ulcerogenic potential of (-)-myrtenol against ethanol-induced gastric lesions and to elucidate the underlying mechanism(s). METHODS: Gastroprotective activity of (-)-myrtenol was evaluated using the mouse model of ethanol-induced gastric damage. To elucidate the gastroprotective mechanism(s), the roles of GABA, prostaglandins, nitric oxide and KATP channels were assessed...
August 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27247854/exogenous-dopamine-reduces-gaba-receptor-availability-in-the-human-brain
#20
Hans C Lou, Astrid Rosenstand, David J Brooks, Dirk Bender, Steen Jakobsen, Jakob U Blicher, Kim V Hansen, Arne Møller
BACKGROUND: While it has recently been shown that dopamine release stimulates conscious self-monitoring through the generation of gamma oscillations in medial prefrontal/anterior cingulate cortex, and that the GABAergic system is effective in producing such oscillations, interaction of the two transmitter systems has not been demonstrated in humans. We here hypothesize that dopamine challenge stimulates the GABA system directly in the medial prefrontal/anterior cingulate region in the human brain...
July 2016: Brain and Behavior
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