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Elodie Gaulin, Michiel J C Pel, Laurent Camborde, Hélène San-Clemente, Sarah Courbier, Marie-Alexane Dupouy, Juliette Lengellé, Marine Veyssiere, Aurélie Le Ru, Frédéric Grandjean, Richard Cordaux, Bouziane Moumen, Clément Gilbert, Liliana M Cano, Jean-Marc Aury, Julie Guy, Patrick Wincker, Olivier Bouchez, Christophe Klopp, Bernard Dumas
BACKGROUND: Oomycetes are a group of filamentous eukaryotic microorganisms that have colonized all terrestrial and oceanic ecosystems, and they include prominent plant pathogens. The Aphanomyces genus is unique in its ability to infect both plant and animal species, and as such exemplifies oomycete versatility in adapting to different hosts and environments. Dissecting the underpinnings of oomycete diversity provides insights into their specificity and pathogenic mechanisms. RESULTS: By carrying out genomic analyses of the plant pathogen A...
April 18, 2018: BMC Biology
Jacobo Galán, Isaac Martin, Itziar Carmona, José María Rodriguez-Barbero, Esperanza Cuadrado, Luis García-Alonso, José Antonio García-Vela
Primary effusion lymphoma (PEL) is a rare B cell lymphoproliferative disorder that arises predominantly in body cavities causing malignant effusions.The incidence of PEL is very low, accounting for approximately 4% of all HIV-associated non-Hodgkin lymphomas. PEL has also been described in elderly patients and after solid-organ transplantation. It is associated in all cases with human herpesvirus 8 (HHV8). We describe a case of PEL in a 88-year-old HIV-negative woman who presented with progressive dyspnea and moderate right-sided pleural effusion without significate lymphadenopathies or other effusions...
April 18, 2018: Cytometry. Part B, Clinical Cytometry
Aude Jary, Valentin Leducq, Romain Palich, Adélie Gothland, Diane Descamps, Véronique Joly, Sidonie Lambert-Niclot, Corinne Amiel, Ana Canestri, Audrey Mirand, Elyanne Gault, Astrid Vabret, Marc-Antoine Valantin, Christine Katlama, Vincent Calvez, Nicolas Dupin, Jean-Philippe Spano, Anne-Geneviève Marcelin
Kaposi Sarcoma-Associated Herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS) but also in multicentric variant of Castleman disease (MCD) and primary effusion lymphoma (PEL), diseases occurring primarily in HIV-infected patients (1).….
April 11, 2018: Journal of Clinical Microbiology
Hamza Hashmi, Drew Murray, Samer Al-Quran, William Tse
Primary effusion lymphoma (PEL) is a unique form of non-Hodgkin lymphoma, usually seen in severely immunocompromised, HIV-positive patients. PEL is related to human herpesvirus-8 (HHV-8) infection, and it usually presents as a lymphomatous body cavity effusion in the absence of a solid tumor mass. There have been very few case reports of HIV-positive patients with HHV-8-positive solid tissue lymphomas not associated with an effusion (a solid variant of PEL). In the absence of effusion, establishing an accurate diagnosis can be challenging, and a careful review of morphology, immunophenotype, and presence of HHV-8 is necessary to differentiate from other subtypes of non-Hodgkin lymphoma...
2018: Case Reports in Hematology
Shreemayee Satapathy, C R Panda
This study investigated the source and contamination levels of toxic elements (Cd, Cr, As, Pb, Ni and Hg) present in a coastal environment, Paradip-an industrial hub of the east coast of India. The ecological risk assessment indices and human exposure models were used to evaluate the pollution status. Enrichment factor indicated that all the metal(loid)s found in the sediment are mostly derived from the anthropogenic source. According to the sediment quality quotient, 8.33% of sediments have crossed the ERM limit for Ni that can be fatal to biota...
March 26, 2018: Environmental Geochemistry and Health
Dalal Asker, Tarek S Awad, Perrin Baker, P Lynne Howell, Benjamin D Hatton
Bacterial colonization and biofilm formation on surfaces are typically mediated by the deposition of exopolysaccharides and conditioning protein layers. Pseudomonas aeruginosa is a nosocomial opportunistic pathogen that utilizes strain-specific exopolysaccharides such as Psl, Pel or alginate for both initial surface attachment and biofilm formation. To generate surfaces that resist P. aeruginosa colonization, we covalently bound a Psl-specific glycoside hydrolase (PslGh ) to several, chemically-distinct surfaces using amine functionalization (APTMS) and glutaraldehyde (GDA) linking...
March 14, 2018: Biomaterials
Christopher Rimmer, Philip Adds
The existence of posterior epidural ligaments (PEL) has been established in the lumbar region, but they have hitherto not been shown to exist in the thoracic vertebral column. Their identification is of clinical significance in respect to incidental durotomy and the circulation of cerebro-spinal fluid. Fourteen thoracic spine sections were dissected by cutting through the intervertebral disc and separating the ligamentum flavum from the vertebra above. The dural sheath was gently retracted anteriorly to identify macroscopic connections between the ligamentum flavum and the dura...
March 23, 2018: Folia Morphologica (Warsz)
Daphna Paran, Yoav Smith, Shlomo Pundak, Uri Arad, David Levartovsky, Ilana Kaufman, Jonathan Wollman, Victoria Furer, Adi Broyde, Ofir Elalouf, Dan Caspi, Sara Pel, Ori Elkayam
OBJECTIVES: Rheumatoid arthritis (RA) patients have many therapeutic options; however, tools to predict individual patient response are limited. The Genefron personal diagnostic kit, developed by analyzing large datasets, utilizes selected interferon stimulated gene expressions to predict treatment response. This study evaluates the kit's prediction accuracy of individual RA patients' response to tumor necrosis alpha (TNFα) blockers. METHODS: A retrospective analysis was performed on RA patients reported in published datasets...
March 23, 2018: Current Medical Research and Opinion
Olga Cavoura, Christine M Davidson, Nicholas Katsiris, Helen E Keenan
A rapid, inexpensive, colorimetric screening method for mercury (Hg) has been optimized to provide a semi-quantitative measurement of Hg concentration in marine sediment within the range 0.038 to 1.5 mg kg-1 encompassing the interim sediment quality guideline (ISQG) value of 0.13 mg kg-1 (CCME 1999) and the probable effects level (PEL) of 0.7 mg kg-1 for Hg in marine sediment (CCME 1999). Neither salinity (up to 41 practical salinity units (psu)) nor sediment organic matter (ΟΜ) content (up to 10%) affected the performance of the method...
March 21, 2018: Environmental Monitoring and Assessment
Christopher D Zevitas, John D Spengler, Byron Jones, Eileen McNeely, Brent Coull, Xiaodong Cao, Sin Ming Loo, Anna-Kate Hard, Joseph G Allen
OBJECTIVE: To measure sound levels in the aircraft cabin during different phases of flight. METHODS: Sound level was measured on 200 flights, representing six aircraft groups using continuous monitors. A linear mixed-effects model with random intercept was used to test for significant differences in mean sound level by aircraft model and across each flight phase as well as by flight phase, airplane type, measurement location and proximity to engine noise. RESULTS: Mean sound levels across all flight phases and aircraft groups ranged from 37...
March 15, 2018: Journal of Exposure Science & Environmental Epidemiology
Kimi Okada, Shoji Asakura, Tomofumi Yano, Takumi Kishimoto
Primary effusion lymphoma (PEL) is a rare type of extranodal lymphoma, typically of a B-cell origin, which presents as lymphomatous effusion with no nodal enlargement or tumor masses. The development PEL is universally associated with human herpes virus-8 (HHV-8) infection. Cases of HHV-8-negative primary lymphomatous effusion have recently been reported and referred to as HHV-8-unrelated PEL-like lymphoma. Some cases of this disease have been reported in iatrogenic immunocompromised patients. The mechanisms responsible for the inhibitory effects of the discontinuation of immunosuppressants other than methotrexate (MTX) against the disease, which have been demonstrated for MTX-associated lymphoproliferative disorders, have not yet been elucidated...
March 7, 2018: International Journal of Hematology
M D Cyrus Oster, M D Theodore Stein, M D Sumire Kitahara, M D Serhan Alkan, Qin Huang
Primary effusion lymphoma (PEL) is a distinct clinicopathologic entity usually characterized by presentation as a lymphomatous body cavity effusion in the absence of solid tumor mass or dissemination during its clinical course. PEL can also rarely occur as a solid lymphoma involving nodal and extranodal sites and is referred to as extracavitary PEL. Here we report a unique case of extracavitary PEL in a 49year-old HIV-seropositive patient, who presented with vague abdominal pain and 20 pound weight loss. Esophagogastroduodenoscopy and colonoscopy revealed >100 broad based intestinal polyps ranging from 2 mm to 3cm in size, spreading from the duodenum to the rectum as a typical impression of "intestinal polyposis syndrome"...
March 2, 2018: Human Pathology
Piseth Nhoek, Hee-Sung Chae, Jagadeesh Nagarajappa Masagalli, Karabasappa Mailar, Pisey Pel, Young-Mi Kim, Won Jun Choi, Young-Won Chin
Nine flavonoids were isolated and identified from a chloroform-soluble fraction of the roots of Scutellaria baicalensis through a bioactivity-guided fractionation using a proprotein convertase subtilisin/kexin type 9 (PCSK9) monitoring assay in HepG2 cells. All structures were established by interpreting the corresponding spectroscopic data and comparing measured values from those in the literature. All compounds were assessed for their ability to inhibit PCSK9 mRNA expression; compounds 1 (3,7,2'-trihydroxy-5-methoxy-flavanone) and 4 (skullcapflavone II) were found to suppress PCSK9 mRNA via SREBP-1...
February 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Bruce G Marshall, Marcello M Veiga, Robert J Kaplan, Rebecca Adler Miserendino, Gary Schudel, Bridget A Bergquist, Jean R D Guimarães, Luis G S Sobral, Carolina Gonzalez-Mueller
In Portovelo in southern Ecuador, 87 gold processing centers along the Puyango-Tumbes River produce an estimated 6 tonnes of gold per annum using a combination of mercury amalgamation and/or cyanidation and processing poly-metallic ores. We analysed total Hg, Hg isotopes, total arsenic, cadmium, copper, lead and zinc in water and sediment along the Puyango in 2012-2014. The highest total mercury (THg) concentrations in sediments were found within a 40 km stretch downriver from the processing plants, with levels varying between 0...
March 1, 2018: Environmental Science. Processes & Impacts
Mauricio Díaz, Matias Castro, Sylvia Copaja, Nicolas Guiliani
Acidophile bacteria belonging to the Acidithiobacillus genus are pivotal players for the bioleaching of metallic values such as copper. Cell adherence to ores and biofilm formation, mediated by the production of extracellular polymeric substances, strongly favors bioleaching activity. In recent years, the second messenger cyclic diguanylate (c-di-GMP) has emerged as a central regulator for biofilm formation in bacteria. C-di-GMP pathways have been reported in different Acidithiobacillus species; however, c-di-GMP effectors and signal transduction networks are still largely uncharacterized in these extremophile species...
February 21, 2018: Genes
Dorota Wójcik, Aleksandra Krzewska, Leszek Szalewski, Elżbieta Pietryka-Michałowska, Magdalena Szalewska, Szymon Krzewski, Elżbieta Pels, Iwona Beń-Skowronek
Vitamin D may prevent dental caries. To date, no attempts have been made to examine the correlation between the incidence of caries and the concentrations of vitamin D in children with pituitary growth hormone deficiency.The study observed patients of the Department of Endocrinology and Diabetology of the University Paediatric Hospital of the Medical University of Lublin treated with human recombinant growth hormone for pituitary growth hormone deficiency (GHD). The study was conducted between October 2014 and June 2015...
February 2018: Medicine (Baltimore)
Caetanie F Tchagang, Renlin Xu, Cyr Lézin Doumbou, James T Tambong
Multilocus sequence analysis (MLSA) of two new biological control strains (S1E40 and S3E12) of Pseudomonas was performed to assess their taxonomic position relative to close lineages, and comparative genomics employed to investigate whether these strains differ in key genetic features involved in hypersensitivity responses (HRs). Strain S3E12, at high concentration, incites HRs on tobacco and corn plantlets while S1E40 does not. Phylogenies based on individual genes and 16S rRNA-gyrB-rpoB-rpoD concatenated sequence data show strains S1E40 and S3E12 clustering in distinct groups...
February 21, 2018: MicrobiologyOpen
Shinichiro Ota, Yuji Fujikura, Takayuki Yamamoto, Yohei Maki, Atsushi Kurokawa, Takuya Maeda, Soichiro Kanoh, Akihiko Kawana
Primary effusion lymphoma (PEL) is a rare subtype of large B-cell lymphoma associated with human herpesvirus-8. Most cases are co-infected with Epstein-Barr virus (EBV). The prognosis of PEL is extremely poor and no optimal treatment regimen has been established. We report a case of EBV-negative PEL in a 49-year-old human immunodeficiency virus-positive man, presenting with massive bilateral pleural effusion.
February 14, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Satoshi Otani, Kazufumi Hiramatsu, Kazuhiko Hashinaga, Kosaku Komiya, Kenji Umeki, Kenji Kishi, Jun-Ichi Kadota
Pseudomonas aeruginosa exhibits the biofilm mode of growth and causes chronic as well as acute infections in humans. Several reports have shown that the treatments with sub-minimum inhibitory concentrations (sub-MICs) of antimicrobial agents influence biofilm formation by P. aeruginosa. The antibiotic ceftazidime (CAZ) is used to treat P. aeruginosa infections, but few studies have examined the effects of β-lactams on biofilm formation by P. aeruginosa. In this study, we investigated the role of sub-MICs of CAZ in the formation of P...
February 12, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Elżbieta J Pels
BACKGROUND: Oral mucositis is a problem occurring within the oral cavity, which is the most difficult to deal with during anti-tumor treatment. The first symptom reported by the patient is discomfort. Salivary immunoglobulins play an important role in pathological processes occurring in the oral cavity. OBJECTIVES: The study objective was to assess the occurrence of oral mucositis and to assess changes in the saliva IgA, IgG, and IgM concentration in children with acute lymphoblastic leukemia during antitumor treatment...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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