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Gahee Min, Sae-Kwang Ku, Mi Seon Park, Tae-Joo Park, Hyun-Shik Lee, Jong-Sup Bae
A certain nucleosomal protein-high mobility group box-1 (HMGB1)-has recently been established as a late mediator of sepsis, with a relatively wide therapeutic window for pharmacological intervention. Pelargonidin (PEL) is a well-known red pigment found in plants; it has important biological activities that are potentially beneficial for human health. In the present study, we investigated whether PEL can modulate HMGB1-mediated inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice...
October 24, 2016: Archives of Pharmacal Research
Mark A Otto, Nicholas J Martin, Jennifer S Rous, Michael E Stevens
Dichlorvos is a chemical compound which has been used for decades as a pesticide. Potential inhalational exposure to dichlorvos vapor associated with using commercially-based, dichlorvos-impregnated resin strips in a simulated military guard post was evaluated. A varying number of these pesticide strips, ranging from the manufacturer's guidelines ((3)-16 g strips) up to a full package of strips ((12)-16 g strips), were placed in a small, enclosed space (2.31 m × 2.26 m × 2.44 m, 12.7 m(3)), which was similar in size to a typical military guard post...
October 18, 2016: Journal of Occupational and Environmental Hygiene
Eun Gyung Lee, Rana Magrm, Mohannad Kusti, Michael L Kashon, Steven Guffey, Michelle M Costas, Carie J Boykin, Martin Harper
This study was to determine occupational exposures to formaldehyde and to compare concentrations of formaldehyde obtained by active and passive sampling methods. In one pathology and one histology laboratories, exposure measurements were collected with sets of active air samplers (Supelco LpDNPH tubes) and passive badges (ChemDisk Aldehyde Monitor 571). Sixty-six sample pairs (49 personal and 17 area) were collected and analyzed by NIOSH NMAM 2016 for active samples and OSHA Method 1007 (using the manufacturer's updated uptake rate) for passive samples...
August 11, 2016: Journal of Occupational and Environmental Hygiene
Gabriele Franken, Marita Bruijns-Pötschke, Joachim Richter, Heinz Mehlhorn, Alfons Labisch
For a long time, only two phases of the life cycle of the agents of malaria parasites were known: the cycle inside the mosquito body and the cycle in the red blood cells of humans as intermediate hosts. A possible tissue development cycle inside humans, however, had already been proposed before 1900. In general, Pieter Klaesz Pel is considered the first scientist who has described such a tissue cycle. However, a closer look at Pel's work shows that he still followed an old (conservative) way of thinking, since he still referred to "malaria poison and malaria miasma...
October 7, 2016: Parasitology Research
Esmée E Verhulp, Gonneke W J M Stevens, Trees V M Pels, Caroline M C Van Weert, Wilma A M Vollebergh
Objective: Individuals' lay beliefs about mental health problems and attitudes toward mental health care are thought to be influenced by the cultural background of these individuals. In the current study, we investigated differences between immigrant Dutch and native Dutch parents and adolescents in lay beliefs about emotional problems and attitudes toward mental health care. Additionally, among immigrant Dutch parents, we examined the associations between acculturation orientations and lay beliefs about emotional problems as well as attitudes toward mental health care...
October 6, 2016: Cultural Diversity & Ethnic Minority Psychology
Jayashree A Chandrasekharan, Xiao M Huang, Alexandar Hwang, Neelam Sharma-Walia
: Lipoxins are host anti-inflammatory molecules that play a vital role in restoring tissue homeostasis. The efficacy of lipoxins and their analog epilipoxins in treating inflammation and its associated diseases has been well documented. Kaposi's Sarcoma (KS) and Primary Effusion Lymphoma (PEL) are two well-known inflammation related diseases caused by Kaposi's Sarcoma-Associated Herpesvirus (KSHV). Controlling inflammation is one of the strategies adopted to treat KS and PEL, a primary motivation for exploring and evaluating the therapeutic potential of using lipoxins...
September 28, 2016: Journal of Virology
Ahmed Raza, Abida Farooqi, Asif Javed, Waqar Ali
To assess the trace metal pollution in the Siran River, sediments were collected from 12 sites, from the left and right banks of the river in 2013. The concentrations, accumulation, distribution pattern, and pollution status of heavy metals in sediments were investigated using geoaccumulation index (I geo) and enrichment factor (EF). The toxic risk of heavy metals was assessed using interim sediment quality guidelines (ISQGs), portable effect level (PEL), threshold effect level (TEL), and toxic effect threshold (TET)...
October 2016: Environmental Monitoring and Assessment
Masayuki Oki, Tomihisa Nanao, Takuma Shinoda, Ayumi Tsuda, Atsushi Yasuda, Toshiro Seki, Hideki Ozawa, Naoya Nakamura, Atsushi Takagi
To date, there are only 15 case reports of lymphoma in patients with neurofibromatosis type 1 (NF1), a common autosomal dominant tumor predisposition syndrome. Here, we present the first report of a primary effusion lymphoma (PEL)-like lymphoma (PEL-L), which is a human herpes virus 8/Kaposi sarcoma herpes virus-unrelated PEL, in a 73-year-old woman with NF1. The woman presented with pleural effusion following surgery for a small intestinal gastrointestinal stromal tumor and a malignant peripheral nerve sheath tumor...
2016: Tokai Journal of Experimental and Clinical Medicine
Louis Anthony Tony Cox
Permissible exposure limits (PELs) for respirable crystalline silica (RCS) have recently been reduced from 0.10 to 0.05 mg/m(3). This raises an important question: do current laboratory practices and standards for assessing RCS concentrations permit reliable discrimination between workplaces that are in compliance and workplaces that are not? To find out, this paper examines recent laboratory performance in quantifying RCS amounts on filters sent to them to assess their proficiency. A key finding is that accredited laboratories do not reliably (e...
September 13, 2016: Regulatory Toxicology and Pharmacology: RTP
Jucelino B Silva, Rodrigo A Nascimento, Sergio T de Oliva, Olívia M C de Oliveira, Sergio L C Ferreira
This paper reports the bioavailability of the metals (cadmium, copper, zinc, lead, and nickel) in sediment samples collected in seven stations from the São Paulo Estuary, Todos os Santos Bay, Brazil. The bioavailability was determined by employing the technique "acid-volatile sulfide (AVS) and simultaneously extracted metal (SEM)". The elements cadmium, copper, lead, and zinc were determined using differential pulse anodic stripping voltammetry (DPASV), while nickel was quantified utilizing electrothermal atomic absorption spectrometry (ET AAS)...
October 2015: Environmental Monitoring and Assessment
N Hugouvieux-Cotte-Pattat
Dickeya, a genus of the Enterobacteriaceae family, all cause plant diseases. They are aggressive necrotrophs that have both a wide geographic distribution and a wide host range. As a plant pathogen, Dickeya has had to adapt to a vegetarian diet. Plants constitute a large storage of carbohydrates; they contain substantial amounts of soluble sugars and the plant cell wall is composed of long polysaccharides. Metabolic functions used by Dickeya in order to multiply during infection are essential aspects of pathogenesis...
2016: Progress in Molecular Biology and Translational Science
S Reverchon, G Muskhelisvili, W Nasser
The pectinolytic Dickeya spp. are Gram-negative bacteria causing severe disease in a wide range of plant species. Although the Dickeya genus was initially restricted to tropical and subtropical areas, two Dickeya species (D. dianthicola and D. solani) emerged recently in potato cultures in Europe. Soft-rot, the visible symptoms, is caused by plant cell wall degrading enzymes, mainly pectate lyases (Pels) that cleave the pectin polymer. However, an efficient colonization of the host requires many additional elements including early factors (eg, flagella, lipopolysaccharide, and exopolysaccharide) that allow adhesion of the bacteria and intermediate factors involved in adaptation to new growth conditions encountered in the host (eg, oxidative stress, iron starvation, and toxic compounds)...
2016: Progress in Molecular Biology and Translational Science
Cheng-Cheng Wang, Jia-Rui Yuan, Chun-Fei Wang, Nan Yang, Juan Chen, Dan Liu, Jie Song, Liang Feng, Xiao-Bin Tan, Xiao-Bin Jia
BACKGROUND: Phyllanthus emblica L (PEL), a well-known medical plant, has been used in Asian countries for a long time. Increasing evidence suggests that it can prevent the tumorigenesis of cancer associated with nonresolving inflammation. However, the possible anti-inflammatory mechanism responsible for preventing tumorigenesis of precancerous lung lesions is not well elucidated. MATERIALS AND METHODS: Male A/J mice were randomly divided into 5 groups with 10 mice in each group: (1) blank group (saline), (2) benzo(a)pyrene [B(a)P] group, (3) and (4) B(a)P + PEL (5 g/kg/d, 10 g/kg/d, administered by gavage), (5) B(a)P + celecoxib (30 mg/kg/d, administered by gavage)...
August 24, 2016: Integrative Cancer Therapies
L Bonsignore, K Passelli, C Pelzer, M Perroud, A Konrad, M Thurau, M Stürzl, L Dai, J Trillo-Tinoco, L Del Valle, Z Qin, M Thome
Primary effusion lymphoma (PEL) is an incurable malignancy that develops in immunodeficient patients as a consequence of latent infection of B-cells with Kaposi's sarcoma-associated herpesvirus (KSHV). Malignant growth of KSHV-infected B cells requires the activity of the transcription factor NF-κB, which controls maintenance of viral latency and suppression of the viral lytic program. Here we show that the KSHV proteins K13 and K15 promote NF-κB activation via the protease mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1), a key driver of NF-κB activation in lymphocytes...
August 19, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Madori Osawa, Sohtaro Mine, Shinichiro Ota, Kengo Kato, Tsuyoshi Sekizuka, Makoto Kuroda, Michiyo Kataoka, Hitomi Fukumoto, Yuko Sato, Takayuki Kanno, Hideki Hasegawa, Keiji Ueda, Masashi Fukayama, Takuya Maeda, Soichiro Kanoh, Akihiko Kawana, Yuji Fujikura, Harutaka Katano
BACKGROUND: Primary effusion lymphoma is a rare distinct large B-cell neoplasm that is associated with Kaposi's sarcoma-associated herpesvirus (KSHV) infection. Over recent years, 9 KSHV-positive/Epstein-Barr virus (EBV)-negative PEL cell lines have been established. METHODS: Tumor cells were collected from the pleural effusion of a 49-year-old male with AIDS. Cells were grown in RPMI1640 culture medium supplemented with 10 % fetus bovine serum. Single cell cloning was performed successfully by a limiting dilution method in a 96-well plate...
2016: Infectious Agents and Cancer
Arjun Gupta, Shiraj Sen, Eileen Marley, Weina Chen, Harris V Naina
BACKGROUND: Primary effusion lymphoma (PEL) is a rare malignancy usually associated with HIV infection. Management and outcomes are poorly understood. METHODS: The medical records of all patients diagnosed with HIV-associated PEL at our institution between 1999 and 2014 were reviewed. Patients were followed till death, treatment failure or loss of follow-up. RESULTS: Twelve patients with PEL were identified during the 15 year study period; 9 had HIV infection...
August 2016: Clinical Lymphoma, Myeloma & Leukemia
Fengqin Li, Yongjun Jian, Long Chang, Guangpu Zhao, Liangui Yang
In this work, we investigate the time periodic electroosmotic flow (EOF) of an electrolyte solution through a slit polyelectrolyte-grafted (PE-grafted) nanochannel under applied alternating current (AC) electrical field. The PE-grafted nanochannel is represented by a rigid surface covered by a polyelectrolyte layer (PEL) in a brush-like configuration. Under Debye-Hückel approximation, we obtain analytical solutions of electrical potential in decoupled regime of PE-grafted nanochannel, where the thickness of PEL is independent of the electrostatic effects triggered by polyelectrolyte charges...
November 1, 2016: Colloids and Surfaces. B, Biointerfaces
Mindy C Kohlhagen, David R Barnidge, John R Mills, Joshua Stoner, Kari M Gurtner, Andrea M Liptac, Denise I Lofgren, Patrick M Vanderboom, Angela Dispenzieri, Jerry A Katzmann, Maria A V Willrich, Melissa R Snyder, David L Murray
BACKGROUND: Current recommendations for screening for monoclonal gammopathies include serum protein electrophoresis (PEL), imunofixation electrophoresis (IFE), and free light chain (FLC) ratios to identify or rule out an M-protein. The aim of this study was to examine the feasibility of an assay based on immunoenrichment and MALDI-TOF-MS (MASS-SCREEN) to qualitatively screen for M-proteins. METHODS: Serum from 556 patients previously screened for M-proteins by PEL and IFE were immunopurified using a κ/λ-specific nanobody bead mixture...
October 2016: Clinical Chemistry
Jennifer J Wood, James R Boyne, Christina Paulus, Brian R Jackson, Michael M Nevels, Adrian Whitehouse, David J Hughes
UNLABELLED: Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of commonly fatal malignancies of immunocompromised individuals, including primary effusion lymphoma (PEL) and Kaposi's sarcoma (KS). A hallmark of all herpesviruses is their biphasic life cycle-viral latency and the productive lytic cycle-and it is well established that reactivation of the KSHV lytic cycle is associated with KS pathogenesis. Therefore, a thorough appreciation of the mechanisms that govern reactivation is required to better understand disease progression...
October 15, 2016: Journal of Virology
María Antonia Molina-Henares, María Isabel Ramos-González, Abdelali Daddaoua, Ana María Fernández-Escamilla, Manuel Espinosa-Urgel
The intracellular signal molecule cyclic di-GMP (c-di-GMP) is an important element in regulation of biofilm formation by bacteria. In Pseudomonas aeruginosa, FleQ functions as a c-di-GMP-dependent transcriptional regulator of expression of flagellar genes and the exopolysaccharide (EPS) Pel, a component of the biofilm extracellular matrix. In the plant-beneficial bacterium Pseudomonas putida KT2440, a mutation in fleQ reduces biofilm formation and colonization of plant surfaces. Using isothermal titration calorimetry and electrophoretic mobility shift assays, we show in this work that FleQ of P...
August 5, 2016: Research in Microbiology
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