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https://www.readbyqxmd.com/read/28196090/the-uniqueness-of-morphological-features-of-pure-erythroid-leukemia-in-myeloid-neoplasm-with-erythroid-predominance-a-reassessment-using-criteria-revised-in-the-2016-world-health-organization-classification
#1
Po-Shen Ko, Yao-Chung Liu, Chiu-Mei Yeh, Jyh-Pyng Gau, Yuan-Bin Yu, Liang-Tsai Hsiao, Cheng-Hwai Tzeng, Po-Min Chen, Tzeon-Jye Chiou, Chia-Jen Liu, Jin-Hwang Liu
We reviewed 97 consecutive cases of myeloid neoplasm with erythroid predominance (MN-EP) between 2000 and 2015. Following 2016 WHO classification, MN-EP patients were classified into four groups. Eight pure erythroid leukemia (PEL) (including t-MN and AML-MRC morphologically fulfilled criteria for PEL) patients had dismal outcomes (median OS: 1 month) and showed more bone marrow fibrosis, worse performance status (PS) and higher serum lactate dehydrogenase (LDH) at diagnosis than the other groups. In the univariate analysis, risks of death in MN-EP patients included the morphologic features of PEL, very poor cytogenetic risk by IPSS-R, bone marrow fibrosis, leukocytosis, anemia, hypoalbuminemia, high LDH, and poor PS...
2017: PloS One
https://www.readbyqxmd.com/read/28184988/cloning-evaluation-and-high-level-expression-of-a-thermo-alkaline-pectate-lyase-from-alkaliphilic-bacillus-clausii-with-potential-in-ramie-degumming
#2
Cheng Zhou, Yanfen Xue, Yanhe Ma
Alkaline pectate lyases (Pels) have potential application in bioscouring of the textile industry. In this study, a thermo-alkaline Pel (BacPelA) gene from an alkaliphilic Bacillus clausii strain was cloned and overexpressed in Escherichia coli. The mature BacPelA exhibited maximum activity at pH 10.5 and 70 °C and showed high cleavage capability on methylated pectins. BacPelA showed the highest specific activity of 936.2 U mg(-1) on ≥85% methylated pectin and 675.5 U mg(-1) on standard substrate polygalacturonic acid (PGA) upon evaluation of the absorbance at 235 nm (A235)...
February 9, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28167523/the-role-of-cyclic-di-gmp-and-exopolysaccharide-in-type-iv-pilus-dynamics
#3
Jan Ribbe, Amy E Baker, Sebstian Euler, George A O'Toole, Berenike Maier
For Pseudomonas aeruginosa the levels of cyclic di-GMP govern the transition from the planktonic state to biofilm formation. Type IV pili (T4P) are crucial determinants of biofilm structure and dynamics, but it is unknown how the levels of c-di-GMP affect pilus dynamics. Here, we scrutinized how c-di-GMP affects molecular motor properties and adhesive behavior of T4P. By means of retraction, T4P generated forces of ∼ 30 pN. Deletion mutants in the proteins with known roles in biofilm formation, swarming motility and exopolysaccharide (EPS) production, specifically, the diguanulate cyclases sadC and roeA or the c-di-GMP phosphodiesterase bifA, showed only modest effects on velocity or force of T4P retraction...
February 6, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28167419/comparative-pharmacokinetic-profiles-of-selected-irreversible-tyrosine-kinase-inhibitors-neratinib-and-pelitinib-with-apigenin-in-rat-plasma-by-uplc-ms-ms
#4
Hadir M Maher, Nourah Z Alzoman, Shereen M Shehata, Ashwag O Abahussain
Neratinib (NER) and pelitinib (PEL) are irreversible tyrosine kinase inhibitors (TKIs) that have been recently employed in cancer treatment. Apigenin (API), among other flavonoids, is known to have antioxidant, anti-proliferative, and carcinogenic effect. API can potentiate the antitumor effect of chemotherapeutic agents and/or alleviate the side effects of many anticancer agents. Since TKIs are mostly metabolized by CYP3A4 enzymes and that API could alter the enzymatic activity, potential drug interactions could be expected following their co-aministration...
January 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28161410/methylseleninic-acid-and-sodium-selenite-induce-severe-er-stress-and-subsequent-apoptosis-through-upr-activation-in-pel-cells
#5
Zenpei Shigemi, Kazuki Manabe, Naoko Hara, Yusuke Baba, Kohei Hosokawa, Hiroki Kagawa, Tadashi Watanabe, Masahiro Fujimuro
Selenium compounds such as methylseleninic acid (MSA) and sodium selenite (SS) have been widely evaluated as potential anti-cancer agents in the clinical setting. Primary effusion lymphoma (PEL) is a non-Hodgkin's B-cell lymphoma, associated with immunosuppressed individuals, such as post-transplant or AIDS patients. Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of PEL and Kaposi's sarcoma. Here, we found that MSA and SS markedly inhibited the growth of PEL cells compared with KSHV-uninfected B cells...
February 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28146424/up-regulation-of-tumor-suppressor-genes-by-exogenous-dhc16-cer-contributes-to-its-anti-cancer-activity-in-primary-effusion-lymphoma
#6
Yueyu Cao, Jing Qiao, Zhen Lin, Jovanny Zabaleta, Lu Dai, Zhiqiang Qin
Primary effusion lymphoma (PEL) is a rare and highly aggressive B-cell malignancy with Kaposi's sarcoma-associated herpesvirus (KSHV) infection, while lack of effective therapies. Our recent data indicated that targeting the sphingolipid metabolism by either sphingosine kinase inhibitor or exogenous ceramide species induces PEL cell apoptosis and suppresses tumor progression in vivo. However, the underlying mechanisms for these exogenous ceramides "killing" PEL cells remain largely unknown. Based on the microarray analysis, we found that exogenous dhC16-Cer treatment affected the expression of many cellular genes with important functions within PEL cells such as regulation of cell cycle, cell survival/proliferation, and apoptosis/anti-apoptosis...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28145945/training-internal-medicine-residents-in-social-medicine-and-research-based-health-advocacy-a-novel-in-depth-curriculum
#7
Gaurab Basu, Richard J Pels, Rachel L Stark, Priyank Jain, David H Bor, Danny McCormick
PROBLEM: Health disparities are pervasive worldwide. Physicians have a unique vantage point from which they can observe the ways social, economic, and political factors impact health outcomes and can be effective advocates for enhanced health outcomes and health equity. However, social medicine and health advocacy curricula are uncommon in postgraduate medical education. APPROACH: In academic year (AY) 2012, the Cambridge Health Alliance internal medicine residency program transformed an elective into a required social medicine and research-based health advocacy curriculum...
January 31, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28144286/study-of-clinical-haematological-and-cytogenetic-profile-of-patients-with-acute-erythroid-leukaemia
#8
Jacob Abraham Linu, Ms Namratha Udupa, D S Madhumathi, K C Lakshmaiah, K Govind Babu, D Lokanatha, Mc Suresh Babu, K N Lokesh, L K Rajeev, A H Rudresha
BACKGROUND: Acute erythroid leukaemia (AEL) is a rare subtype of acute myeloid leukaemia (AML), constituting <5% of all the cases of AML. The World Health Organization (WHO) in 2001 classified AEL into two types: (1) erythroid/myeloid leukaemia which required ≥50% erythroid precursors with ≥20% of the non-erythroid cells to be myeloid blasts and (2) pure erythroleukemia (pEL) with ≥80% erythroblasts. The WHO 2008 classification kept these subcategories, but made erythroleukemia a diagnosis of exclusion...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28139296/lignans-from-the-fruits-of-schisandra-chinensis-turcz-baill-inhibit-proprotein-convertase-subtilisin-kexin-type-9-expression
#9
Pisey Pel, Hee-Sung Chae, Piseth Nhoek, Woojin Yeo, Young-Mi Kim, Young-Won Chin
Bioactivity-guided fractionation of the fruits of Schisandra chinensis, using the proprotein convertase subtilisin-kexin type 9 (PCSK9) mRNA expression screening assay, led to isolation of two previously unknown lignans, 14-tigloylschinlignan D and rel-(7R, 8R, 7'R, 8'R)-manglisin E, along with 28 known compounds. All structures were established by NMR spectroscopic data as well as CD and MS analysis. All isolates were tested for their inhibitory activities on the mRNA expression of PCSK9. Of the tested compounds, four of the compounds rel-(7R, 8R, 7'R, 8'R)-manglisin E, (-)-schisandrin C, schinlignan D, and (+)-schisandrol B potently inhibited PCSK9 mRNA expression with IC50 values of 3...
January 27, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28137803/importance-of-the-exopolysaccharide-matrix-in-antimicrobial-tolerance-of-pseudomonas-aeruginosa-aggregates
#10
Lise Goltermann, Tim Tolker-Nielsen
Pseudomonas aeruginosa is an opportunistic pathogen that can infect the lungs of cystic fibrosis (CF) patients, and persist in the form of antibiotic tolerant aggregates in the mucus. It has recently been suggested that such aggregates are formed due to restricted bacterial motility independent of the production of extracellular matrix components, and that they do not rely on an extracellular matrix for antimicrobial tolerance. However, we show here that biofilm matrix over-expression, as displayed by various clinical isolates, significantly protects P...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28131077/distribution-of-pahs-in-different-compartment-of-creek-ecosystem-ecotoxicological-concern-and-human-health-risk
#11
M Tiwari, S K Sahu, G G Pandit
We report levels of polycyclic aromatic hydrocarbons in sediment, seawater, fish and crab samples from Thane creek, India. Concentrations of sixteen USEPA PAH in sediments varies from 874 to 1925ngg(-1), dry weight (dw) in winter, between 219-495ngg(-1) in summer. In seawater Σ16 PAHs concentration during winter was recorded 706±193ngL(-1), and during summer 337±79ngL(-1). Total concentrations of PAHs in consumable portion of lizard fish, bombay duck and crab were found 156.8±18 and 122±24.5ngg(-1), 117...
January 15, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28122468/kshv-associated-extracavitary-primary-effusion-lymphoma-in-an-hiv-seronegative-patient-a-case-report-and-review-of-the-literature
#12
Uroosa Ibrahim, Amina Saqib, Farhan Mohammad, Juan Ding, Shafinaz Hussein, Jean Paul Atallah
Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin's lymphoma presenting as a lymphomatous effusion and absence of a solid tumor mass. Extracavitary PEL (EC-PEL) is a subtype of PEL with the absence of an effusion but presence of solid tumor. PEL and EC-PEL share the same histopathologic and immunophenotypic features. Kaposi sarcoma-associated herpesvirus (KSHV) positivity is seen universally in these malignancies and is a requisite for diagnosis. Most cases are seen to occur in HIV positive individuals...
January 26, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28118409/epigenetic-landscape-of-kaposi-s-sarcoma-associated-herpesvirus-genome-in-classic-kaposi-s-sarcoma-tissues
#13
Rui Sun, Xiaohua Tan, Xing Wang, Xiaodong Wang, Lei Yang, Erle S Robertson, Ke Lan
Kaposi's sarcoma-associated herpesvirus (KSHV) is etiologically related to Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). It typically displays two different phases in its life cycle, the default latency and occasional lytic replication. The epigenetic modifications are thought to determine the fate of KSHV infection. Previous studies elegantly depicted epigenetic landscape of latent viral genome in in vitro cell culture systems. However, the physiologically relevant scenario in clinical KS tissue samples is unclear...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28107481/bet-inhibitors-disrupt-rad21-dependent-conformational-control-of-kshv-latency
#14
Horng-Shen Chen, Alessandra De Leo, Zhuo Wang, Andrew Kerekovic, Robert Hills, Paul M Lieberman
Kaposi's Sarcoma-associated Herpesvirus (KSHV) establishes stable latent infection in B-lymphocytes and pleural effusion lymphomas (PELs). During latency, the viral genome persists as an epigenetically constrained episome with restricted gene expression programs. To identify epigenetic regulators of KSHV latency, we screened a focused small molecule library containing known inhibitors of epigenetic factors. We identified JQ1, a Bromodomain and Extended Terminal (BET) protein inhibitor, as a potent activator of KSHV lytic reactivation from B-cells carrying episomal KSHV...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28099521/nuclear-localization-and-cleavage-of-stat6-is-induced-by-kaposi-s-sarcoma-associated-herpesvirus-for-viral-latency
#15
Chong Wang, Caixia Zhu, Fang Wei, Shujun Gao, Liming Zhang, Yuhong Li, Yanling Feng, Yin Tong, Jianqing Xu, Bin Wang, Zhenghong Yuan, Erle S Robertson, Qiliang Cai
Emerging evidence implies that STAT6 plays an important role in both the adaptive and innate immune responses to virus infection. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus agent associated with several human malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphomas (PELs). Previously, we demonstrated that KSHV blocks IL-4-induced STAT6 phosphorylation and retains a basal IL-13/STAT6 constitutive activation for cell survival and proliferation. However, the mechanism by which KSHV regulates STAT6 remains largely unknown...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28092744/quercetin-induces-apoptosis-and-autophagy-in-primary-effusion-lymphoma-cells-by-inhibiting-pi3k-akt-mtor-and-stat3-signaling-pathways
#16
Marisa Granato, Celeste Rizzello, Maria Saveria Gilardini Montani, Laura Cuomo, Marina Vitillo, Roberta Santarelli, Roberta Gonnella, Gabriella D'Orazi, Alberto Faggioni, Mara Cirone
Quercetin, a bioflavonoid contained in several vegetables daily consumed, has been studied for long time for its antiinflammatory and anticancer properties. Quercetin interacts with multiple cancer-related pathways such as PI3K/AKT, Wnt/β-catenin and STAT3. These pathways are hyperactivated in primary effusion lymphoma (PEL), an aggressive B cell lymphoma whose pathogenesis is strictly linked to the oncogenic virus Kaposis' Sarcoma-associated Herpesvirus (KSHV). In this study, we found that quercetin inhibited PI3K/AKT/mTOR and STAT3 pathways in PEL cells, and as a consequence, it down-regulated the expression of the prosurvival cellular proteins such as c-FLIP, cyclin D1 and cMyc...
January 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28063555/diagnostic-%C3%A3-valuation-et-prise-en-charge-des-troubles-hypertensifs-de-la-grossesse-r%C3%A3-sum%C3%A3-directif
#17
Laura A Magee, Anouk Pels, Michael Helewa, Evelyne Rey, Peter von Dadelszen
No abstract text is available yet for this article.
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28063451/relationship-between-the-potential-energy-landscape-and-the-dynamic-crossover-in-a-water-like-monatomic-liquid-with-a-liquid-liquid-phase-transition
#18
Gang Sun, Limei Xu, Nicolas Giovambattista
In the case of fragile liquids, dynamical properties such as the structural relaxation time evolve from Arrhenius at high-temperatures to non-Arrhenius at low temperatures. Computational studies show that (i) in the Arrhenius dynamic domain, the liquid samples regions of the potential energy landscape (PEL) that are insensitive to temperature (PEL-independent regime) and the relaxation is exponential, while (ii) in the non-Arrhenius dynamic domain, the topography of the PEL explored by the liquid varies with temperature (PEL-influenced regime) and the relaxation is non-exponential...
January 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28060523/anti-inflammatory-effects-of-pelargonidin-on-tgfbip-induced-responses
#19
Seongdo Jeong, Sae-Kwang Ku, Jong-Sup Bae
Transforming growth factor β induced protein (TGFBIp) is an extracellular matrix protein expressed in several cell types in response to TGF-β. TGFBIp is released by human umbilical vein endothelial cells (HUVECs) and functions as a mediator of experimental sepsis. Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. This study was undertaken to investigate whether PEL can modulate TGFBIp-mediated inflammatory responses in HUVECs and in mice...
November 1, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28057051/what-is-the-normal-value-of-the-neutrophil-to-lymphocyte-ratio
#20
Patrice Forget, Céline Khalifa, Jean-Philippe Defour, Dominique Latinne, Marie-Cécile Van Pel, Marc De Kock
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) has proven its prognostic value in cardiovascular diseases, infections, inflammatory diseases and in several types of cancers. However, no cut-off has been proposed on the basis of reference values coming from healthy population. METHODS: Routine blood samples were obtained (n = 413) from workers (age: median 38, range: 21-66 years) involved in a health care prevention program, to determine means, standard deviations (SDs), 95% confidence intervals (95% CI), percentiles P2...
January 3, 2017: BMC Research Notes
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