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https://www.readbyqxmd.com/read/27925401/dickeya-dadantii-pectic-enzymes-necessary-for-virulence-are-also-responsible-for-activation-of-the-arabidopsis-thaliana-innate-immune-system
#1
Dominique Expert, Oriane Patrit, Vladimir E Shevchik, Claude Perino, Virginie Boucher, Creze Christophe, Estelle Wenes, Mathilde Fagard
Soft-rot diseases of plants attributed to Dickeya dadantii result from lysis of plant cell wall due to pectic enzymes released by the bacterial cell by a type II secretion system (T2SS). A. thaliana can express several lines of defence against this bacterium. We employed bacterial mutants with defective envelope structures or secreted proteins to examine early plant defence reactions. We focused on the production of AtrbohD-dependent ROS, callose deposition and cell death as indicators of these reactions. We observed a significant reduction in ROS and callose formation with a bacterial mutant where genes encoding five pectate lyases (Pels) were disrupted...
December 7, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27907079/identification-of-pectin-degrading-enzymes-secreted-by-xanthomonas-oryzae-pv-oryzae-and-determination-of-their-role-in-virulence-on-rice
#2
Lavanya Tayi, Roshan V Maku, Hitendra Kumar Patel, Ramesh V Sonti
Xanthomonas oryzae pv.oryzae (Xoo) causes the serious bacterial blight disease of rice. Xoo secretes a repertoire of plant cell wall degrading enzymes (CWDEs) like cellulases, xylanases, esterases etc., which act on various components of the rice cell wall. The major cellulases and xylanases secreted by Xoo have been identified and their role in virulence has been determined. In this study, we have identified some of the pectin degrading enzymes of Xoo and assessed their role in virulence. Bioinformatics analysis indicated the presence of four pectin homogalacturonan (HG) degrading genes in the genome of Xoo...
2016: PloS One
https://www.readbyqxmd.com/read/27893813/azidothymidine-sensitizes-primary-effusion-lymphoma-cells-to-kaposi-sarcoma-associated-herpesvirus-specific-cd4-t-cell-control-and-inhibits-virf3-function
#3
Samantha J Williamson, Samantha M Nicol, Michael Stürzl, Shereen Sabbah, Andrew D Hislop
Kaposi sarcoma-associated herpesvirus (KSHV) is linked with the development of Kaposi sarcoma and the B lymphocyte disorders primary effusion lymphoma (PEL) and multi-centric Castleman disease. T cell immunity limits KSHV infection and disease, however the virus employs multiple mechanisms to inhibit efficient control by these effectors. Thus KSHV-specific CD4+ T cells poorly recognize most PEL cells and even where they can, they are unable to kill them. To make KSHV-infected cells more sensitive to T cell control we treated PEL cells with the thymidine analogue azidothymidine (AZT), which sensitizes PEL lines to Fas-ligand and TRAIL challenge; effector mechanisms which T cells use...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27888664/ebv-associated-but-hhv8-unrelated-double-hit-effusion-based-lymphoma
#4
Bo-Jung Chen, David Yen-Ting Chen, Chun-Chi Kuo, Shih-Sung Chuang
Effusion-based lymphoma is a rare and unique type of large B-cell lymphoma presenting in effusion without a mass lesion. It shares many clinicopathological features with primary effusion lymphoma (PEL), but is distinct from PEL by the absence of HHV8 association. Double hit lymphoma (DHL) is an aggressive B-cell lymphoma, defined by concurrent rearrangement of MYC and BCL2 or BCL6. DHL often presents as lymphadenopathy or an extranodal mass, but rarely occurs in effusion. Here we report a 61-year-old male with alcoholic cirrhosis presenting as massive ascites and left pleural effusion...
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27884151/unearthing-the-transition-rates-between-photoreceptor-conformers
#5
Robert W Smith, Britta Helwig, Adrie H Westphal, Eran Pel, Maximilian Hörner, Hannes M Beyer, Sophia L Samodelov, Wilfried Weber, Matias D Zurbriggen, Jan Willem Borst, Christian Fleck
BACKGROUND: Obtaining accurate estimates of biological or enzymatic reaction rates is critical in understanding the design principles of a network and how biological processes can be experimentally manipulated on demand. In many cases experimental limitations mean that some enzymatic rates cannot be measured directly, requiring mathematical algorithms to estimate them. Here, we describe a methodology that calculates rates at which light-regulated proteins switch between conformational states...
November 25, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/27871188/what-can-35-years-and-over-700-000-measurements-tell-us-about-noise-exposure-in-the-mining-industry
#6
Benjamin Roberts, Kan Sun, Richard L Neitzel
OBJECTIVE: To analyse over 700,000 cross-sectional measurements from the Mine Safety and Health Administration (MHSA) and develop statistical models to predict noise exposure for a worker. DESIGN: Descriptive statistics were used to summarise the data. Two linear regression models were used to predict noise exposure based on MSHA-permissible exposure limit (PEL) and action level (AL), respectively. Twofold cross validation was used to compare the exposure estimates from the models to actual measurement...
November 22, 2016: International Journal of Audiology
https://www.readbyqxmd.com/read/27859456/clinical-characteristics-and-survival-outcome-of-primary-effusion-lymphoma-a-review-of-105-patients
#7
Mohamed Abd El-Fattah
Primary effusion lymphoma (PEL) is a rare and an aggressive B-cell non-Hodgkin lymphoma with a distinctive clinicobiological features. As a result of the rarity of this malignancy, the overwhelming majority of data come from a case reports or series. Our study aimed to evaluate the clinical features and the survival outcomes of 105 patients with PEL who diagnosed between 2001 and 2012 from the Surveillance Epidemiology and End Results database 18 of the US National Cancer Institute. The Kaplan-Meier curves were constructed and the multivariate Cox model was built to identify survival prognostic factors...
November 18, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27849537/adaptive-progressive-motion-vector-resolution-selection-based-on-rate-distortion-optimization
#8
Zhao Wang, Shiqi Wang, Jian Zhang, Siwei Ma
In the state-of-the-art H.265/HEVC video coding standard, the motion vector (MV) resolution is fixed to be 1/4-pel for the entire video sequence, while the inherent video characteristics, e.g. texture complexities and motion activities have been largely ignored. Obviously such strategy may not suffice the demand of high-accuracy motion compensation. In this paper, we propose a specially designed rate-distortion model in terms of the MV resolution by taking the video characteristics into consideration. In particular, the MV resolution selection is formulated as a rate-distortion optimization problem by analyzing the rate-distortion cost of each MV resolution candidate...
November 10, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27829174/a-chimeric-protein-composed-of-numa-fused-to-the-dna-binding-domain-of-lana-is-sufficient-for-the-ori-p-dependent-dna-replication
#9
Eriko Ohsaki, Keiji Ueda
The Kaposi's sarcoma-associated herpesvirus (KSHV) genome is stably maintained in KSHV-infected PEL cell lines during cell division. We previously showed that accumulation of LANA in the nuclear matrix fraction could be important for the latent DNA replication, and that the functional significance of LANA should be its recruitment of ori-P to the nuclear matrix. Here, we investigated whether the forced localization of the LANA-DNA binding domain (DBD) to the nuclear matrix facilitated ori-P-containing plasmid replication...
November 6, 2016: Virology
https://www.readbyqxmd.com/read/27826751/suppressive-effects-of-pelargonidin-on-polyphosphate-mediated-vascular-inflammatory-responses
#10
In-Chul Lee, Jong-Sup Bae
Previous reports suggest that human endothelial cells-derived PolyPhosphate (PolyP) is one of the pro-inflammatory mediators. As a well-known red pigment and found in plants, Pelargonidin (PEL) has been known to have several biological activates which are beneficial for human health. This study was undertaken to investigate whether PEL can modulate PolyP-mediated inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice. The anti-inflammatory activities of PEL were determined by measuring permeability, leukocytes adhesion and migration, and activation of pro-inflammatory proteins in PolyP-activated HUVECs and mice...
November 8, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27823778/combining-contamination-indexes-sediment-quality-guidelines-and-multivariate-data-analysis-for-metal-pollution-assessment-in-marine-sediments-of-cienfuegos-bay-cuba
#11
Mirella Peña-Icart, Edenir Rodrigues Pereira-Filho, Lucimar Lopes Fialho, Joaquim A Nóbrega, Carlos Alonso-Hernández, Yoelvis Bolaños-Alvarez, Mario S Pomares-Alfonso
The purpose of the present work was to combine several tools for assessing metal pollution in marine sediments from Cienfuegos Bay. Fourteen surface sediments collected in 2013 were evaluated. Concentrations of As, Cu, Ni, Zn and V decreased respect to those previous reported. The metal contamination was spatially distributed in the north and south parts of the bay. According to the contamination factor (CF) enrichment factor (EF) and index of geoaccumulation (Igeo), Cd and Cu were classified in that order as the most contaminated elements in most sediment...
November 4, 2016: Chemosphere
https://www.readbyqxmd.com/read/27812965/spatial-distribution-enrichment-and-source-of-environmentally-important-elements-in-batticaloa-lagoon-sri-lanka
#12
Madurya Adikaram, Amarasooriya Pitawala, Hiroaki Ishiga, Daham Jayawardana
The present paper is the first documentation of distribution and contamination status of environmentally important elements of superficial sediments in the Batticaloa lagoon that is connected to the largest bay of the world. Surface sediment samples were collected from 34 sites covering all over the lagoon. Concentrations of elements such as As, Cr, Cu, Fe, Nb, Ni, Pb, Sc, Sr, Th, V, Y, Zn, and Zr were measured by X-ray florescence analysis. Geochemically, the lagoon has three different zones that were influenced mainly by fresh water sources, marine fronts, and intermediate mixing zones...
November 3, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27792033/assessment-of-dust-exposure-in-a-steel-plant-in-the-eastern-coast-of-peninsular-malaysia
#13
A H Nurul, B M T Shamsul, I Noor Hassim
BACKGROUND: Steel manufacturing produces dust, fumes, and pollutant gases that may give adverse health effects to the respiratory function of workers. Improper occupational hygiene practice in the workplace will affect both workers wellbeing and productivity. OBJECTIVE: To assess the level of particulate matter [(PM2.5, PM10, and Total Particulate Matter (TPM)], and trace metal dust concentrations in different sections of a steel plant and compare with the occupational exposure values...
October 28, 2016: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/27787356/pegylated-liposomal-encapsulated-doxorubicin-in-cutaneous-composite-lymphoma-a-case-report
#14
Uwe Wollina, Dana Langner, Gesina Hansel, Gunter Haroske
BACKGROUND: Cutaneous composite lymphomas are very rare. Their treatment depends upon the different contributing lymphoma entities. Peripheral T-cell lymphoma, not otherwise specified, (PTCL-NOS) represents an aggressive lymphoma subtype. Follicular cutaneous B-cell lymphoma (FCBCL) runs an indolent course. Treatment with pegylated liposomal encapsulated doxorubicin (PLE-DOXO) has yet not been reported in this entity. CASE PRESENTATION: A 73-year-old male patient presented with 3 rapidly growing, painful nodules on his left leg...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27778275/anti-septic-effects-of-pelargonidin-on-hmgb1-induced-responses-in-vitro-and-in-vivo
#15
Gahee Min, Sae-Kwang Ku, Mi Seon Park, Tae-Joo Park, Hyun-Shik Lee, Jong-Sup Bae
A certain nucleosomal protein-high mobility group box-1 (HMGB1)-has recently been established as a late mediator of sepsis, with a relatively wide therapeutic window for pharmacological intervention. Pelargonidin (PEL) is a well-known red pigment found in plants; it has important biological activities that are potentially beneficial for human health. In the present study, we investigated whether PEL can modulate HMGB1-mediated inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice...
October 24, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27754812/determination-of-airborne-concentrations-of-dichlorvos-over-a-range-of-temperatures-when-using-commercially-available-pesticide-strips-in-a-simulated-military-guard-post
#16
Mark A Otto, Nicholas J Martin, Jennifer S Rous, Michael E Stevens
Dichlorvos is a chemical compound which has been used for decades as a pesticide. Potential inhalational exposure to dichlorvos vapor associated with using commercially-based, dichlorvos-impregnated resin strips in a simulated military guard post was evaluated. A varying number of these pesticide strips, ranging from the manufacturer's guidelines ((3)-16 g strips) up to a full package of strips ((12)-16 g strips), were placed in a small, enclosed space (2.31 m × 2.26 m × 2.44 m, 12.7 m(3)), which was similar in size to a typical military guard post...
October 18, 2016: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/27715715/comparison-between-active-pumped-and-passive-diffusive-sampling-methods-for-formaldehyde-in-pathology-and-histology-laboratories
#17
Eun Gyung Lee, Rana Magrm, Mohannad Kusti, Michael L Kashon, Steven Guffey, Michelle M Costas, Carie J Boykin, Martin Harper
This study was to determine occupational exposures to formaldehyde and to compare concentrations of formaldehyde obtained by active and passive sampling methods. In one pathology and one histology laboratories, exposure measurements were collected with sets of active air samplers (Supelco LpDNPH tubes) and passive badges (ChemDisk Aldehyde Monitor 571). Sixty-six sample pairs (49 personal and 17 area) were collected and analyzed by NIOSH NMAM 2016 for active samples and OSHA Method 1007 (using the manufacturer's updated uptake rate) for passive samples...
January 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/27714452/malaria-relapses-were-already-known-before-1900-a-discussion
#18
Gabriele Franken, Marita Bruijns-Pötschke, Joachim Richter, Heinz Mehlhorn, Alfons Labisch
For a long time, only two phases of the life cycle of the agents of malaria parasites were known: the cycle inside the mosquito body and the cycle in the red blood cells of humans as intermediate hosts. A possible tissue development cycle inside humans, however, had already been proposed before 1900. In general, Pieter Klaesz Pel is considered the first scientist who has described such a tissue cycle. However, a closer look at Pel's work shows that he still followed an old (conservative) way of thinking, since he still referred to "malaria poison and malaria miasma...
October 7, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27709973/lay-beliefs-about-emotional-problems-and-attitudes-toward-mental-health-care-among-parents-and-adolescents-exploring-the-impact-of-immigration
#19
Esmée E Verhulp, Gonneke W J M Stevens, Trees V M Pels, Caroline M C Van Weert, Wilma A M Vollebergh
Objective: Individuals' lay beliefs about mental health problems and attitudes toward mental health care are thought to be influenced by the cultural background of these individuals. In the current study, we investigated differences between immigrant Dutch and native Dutch parents and adolescents in lay beliefs about emotional problems and attitudes toward mental health care. Additionally, among immigrant Dutch parents, we examined the associations between acculturation orientations and lay beliefs about emotional problems as well as attitudes toward mental health care...
October 6, 2016: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/27681120/altering-the-anti-inflammatory-lipoxin-microenvironment-a-new-insight-into-kaposi-s-sarcoma-associated-herpesvirus-pathogenesis
#20
Jayashree A Chandrasekharan, Xiao M Huang, Alexander C Hwang, Neelam Sharma-Walia
: Lipoxins are host anti-inflammatory molecules that play a vital role in restoring tissue homeostasis. The efficacy of lipoxins and their analog epilipoxins in treating inflammation and its associated diseases has been well documented. Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL) are two well-known inflammation related diseases caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Controlling inflammation is one of the strategies adopted to treat KS and PEL, a primary motivation for exploring and evaluating the therapeutic potential of using lipoxins...
December 15, 2016: Journal of Virology
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