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https://www.readbyqxmd.com/read/28524879/energy-landscape-driven-non-equilibrium-evolution-of-inherent-structure-in-disordered-material
#1
Yue Fan, Takuya Iwashita, Takeshi Egami
Complex states in glasses can be neatly expressed by the potential energy landscape (PEL). However, because PEL is highly multi-dimensional it is difficult to describe how the system moves around in PEL. Here we demonstrate that it is possible to predict the evolution of macroscopic state in a metallic glass, such as ageing and rejuvenation, through a set of simple equations describing excitations in the PEL. The key to this simplification is the realization that the step of activation from the initial state to the saddle point in PEL and the following step of relaxation to the final state are essentially decoupled...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28504647/identification-of-a-nucleoside-analog-active-against-adenosine-kinase-expressing-plasma-cell-malignancies
#2
Utthara Nayar, Jouliana Sadek, Jonathan Reichel, Denise Hernandez-Hopkins, Gunkut Akar, Peter J Barelli, Michelle A Sahai, Hufeng Zhou, Jennifer Totonchy, David Jayabalan, Ruben Niesvizky, Ilaria Guasparri, Duane Hassane, Yifang Liu, Shizuko Sei, Robert H Shoemaker, J David Warren, Olivier Elemento, Kenneth M Kaye, Ethel Cesarman
Primary effusion lymphoma (PEL) is a largely incurable malignancy of B cell origin with plasmacytic differentiation. Here, we report the identification of a highly effective inhibitor of PEL. This compound, 6-ethylthioinosine (6-ETI), is a nucleoside analog with toxicity to PEL in vitro and in vivo, but not to other lymphoma cell lines tested. We developed and performed resistome analysis, an unbiased approach based on RNA sequencing of resistant subclones, to discover the molecular mechanisms of sensitivity...
May 15, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28503745/interactions-between-phyb-and-pif-proteins-alter-thermal-reversion-reactions-in-vitro
#3
Robert W Smith, Britta Helwig, Adrie H Westphal, Eran Pel, Jan Willem Borst, Christian Fleck
The dynamic behaviour of the plant red/far-red light photoreceptor phytochrome B (phyB) has been elucidated in natural and synthetic systems. Red light switches phyB from the inactive Pr state to the active Pfr state, a process that is reversed by far-red light. Alongside light signals, phyB activity is constrained by thermal reversion (that is prominent in the dark) and protein-protein interactions between phyB, other phytochrome molecules, and, among others, PHYTOCHROME INTERACTING FACTORs (PIFs). Requirements for phyB-PIF association have been well studied and are central to light-regulated synthetic tools...
May 15, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28503574/vitamin-d-modulates-hematological-parameters-and-cell-migration-into-peritoneal-and-pulmonary-cavities-in-alloxan-diabetic-mice
#4
Leonardo M Bella, Isis Fieri, Fernando H G Tessaro, Eduardo L Nolasco, Fernanda P B Nunes, Sabrina S Ferreira, Carolina B Azevedo, Joilson O Martins
Background/Aims. The effects of cholecalciferol supplementation on the course of diabetes in humans and animals need to be better understood. Therefore, this study investigated the effect of short-term cholecalciferol supplementation on biochemical and hematological parameters in mice. Methods. Male diabetic (alloxan, 60 mg/kg i.v., 10 days) and nondiabetic mice were supplemented with cholecalciferol for seven days. The following parameters were determined: serum levels of 25-hydroxyvitamin D, phosphorus, calcium, urea, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, red blood cell count, white blood cell count (WBC), hematocrit, hemoglobin, differential cell counts of peritoneal lavage (PeL), and bronchoalveolar lavage (BAL) fluids and morphological analysis of lung, kidney, and liver tissues...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28497299/ecotoxicological-and-health-risk-assessment-of-polycyclic-aromatic-hydrocarbons-pahs-in-short-neck-clam-paphia-undulata-and-contaminated-sediments-in-malacca-strait-malaysia
#5
Mehrzad Keshavarzifard, Mohamad Pauzi Zakaria, Reza Sharifi
The distribution, sources, and human health risk assessment of polycyclic aromatic hydrocarbons (PAHs) in surface sediment and the edible tissue of short-neck clam (Paphia undulata) from mudflat ecosystem in the west coast of Malaysia were investigated. The concentrations of ∑16 PAHs varied from 347.05 to 6207.5 and 179.32 to 1657.5 ng g(-1) in sediment and short-neck clam samples, respectively. The calculations of mean PEL quotients (mean-PELQs) showed that the ecological risk of PAHs in the sediment samples was low to moderate-high level, whereas the total health risk through ingestion and dermal contact was considerably high...
May 11, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28481873/restoring-pu-1-induces-apoptosis-and-modulates-viral-transactivation-via-interferon-stimulated-genes-in-primary-effusion-lymphoma
#6
H Goto, R Kariya, E Kudo, Y Okuno, K Ueda, H Katano, S Okada
Primary effusion lymphoma (PEL), which is an aggressive subgroup of B-cell lymphoma associated with Kaposi sarcoma-associated herpes virus/human herpes virus-8, is refractory to the standard treatment, and exhibits a poor survival. Although PU.1 is downregulated in PEL, the potential role of its reduction remains to be elucidated. In this investigation, we analyzed the DNA methylation of PU.1 cis-regulatory elements in PEL and the effect of restoring PU.1 on PEL cells. The mRNA level of PU.1 was downregulated in PEL cells...
May 8, 2017: Oncogene
https://www.readbyqxmd.com/read/28470376/sublethal-effects-in-perinereis-gualpensis-polychaeta-nereididae-exposed-to-mercury-pyrene-sediment-mixture-observed-in-a-multipolluted-estuary
#7
M Díaz-Jaramillo, K S B Miglioranza, P Carriquiriborde, D Marino, C N Pegoraro, G Valenzuela, R Barra
Sediment-living organisms can be subjected to a multi-pollution condition due to an increase in the diversity of contaminants. Sediment mixtures of Mercury (Hg) and some polycyclic aromatics hydrocarbons like Pyrene (Pyr) are common in heavily industrialized coastal zones. In the present study, greater than (>) and less than (<) probable effect concentration levels (PELs) of Hg and Pyr were assessed using spiked sediments in order to determine combined (Hg + Pyr) effects in uptake, metabolization and oxidative balance in the polychaete Perinereis gualpensis at short and medium-term exposure...
May 3, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28468596/multiple-viral-infections-in-primary-effusion-lymphoma-a-model-of-viral-cooperation-in-lymphomagenesis
#8
Annunziata Gloghini, Chiara C Volpi, Ambra V Gualeni, Riccardo Dolcetti, Italia Bongarzone, Paolo De Paoli, Antonino Carbone
Primary effusion lymphoma (PEL) is a rare B-cell lymphoid neoplasm mainly associated with HIV infection, presenting as pleural, peritoneal, and pericardial effusions. A defining property of PEL is its consistent association with Kaposi sarcoma associated herpesvirus (KSHV) infection, and, in most cases, Epstein Barr virus (EBV) co-infection. On these grounds, a review of the literature related to viral cooperation and lymphomagenesis can help to understand the complex interplay between KSHV and EBV in PEL pathogenesis...
May 4, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28459883/nlrx1-negatively-modulates-type-i-ifn-to-facilitate-kshv-reactivation-from-latency
#9
Zhe Ma, Sharon E Hopcraft, Fan Yang, Alex Petrucelli, Haitao Guo, Jenny P-Y Ting, Dirk P Dittmer, Blossom Damania
Kaposi's sarcoma-associated herpesvirus (KSHV) is a herpesvirus that is linked to Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV establishes persistent latent infection in the human host. KSHV undergoes periods of spontaneous reactivation where it can enter the lytic replication phase of its lifecycle. During KSHV reactivation, host innate immune responses are activated to restrict viral replication. Here, we report that NLRX1, a negative regulator of the type I interferon response, is important for optimal KSHV reactivation from latency...
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28459467/ribonucleotide-reductase-represents-a-novel-therapeutic-target-in-primary-effusion-lymphoma
#10
L Dai, Z Lin, J Qiao, Y Chen, E K Flemington, Z Qin
Primary effusion lymphoma (PEL) is a highly aggressive B-cell malignancy that is closely associated with one of oncogenic viruses infection, Kaposi's sarcoma-associated herpesvirus. PEL prognosis is poor and patients barely survive >6 months even following active chemotherapy interventions. There is therefore an urgent need to discover more effective targets for PEL management. We recently found that the ribonucleotide reductase (RR) subunit M2 is potentially regulated by the key oncogenic hepatocyte growth factor/c-MET pathway in PEL...
May 1, 2017: Oncogene
https://www.readbyqxmd.com/read/28455404/a-rice-pectate-lyase-like-gene-is-required-for-plant-growth-and-leaf-senescence
#11
Yujia Leng, Yaolong Yang, Deyong Ren, Lichao Huang, Liping Dai, Yuqiong Wang, Long Chen, Zhengjun Tu, Yihong Gao, Xueyong Li, Li Zhu, Jiang Hu, Guangheng Zhang, Zhenyu Gao, Longbiao Guo, Zhaosheng Kong, Yongjun Lin, Qian Qian, Dali Zeng
To better understand the molecular mechanisms behind plant growth and leaf senescence in monocot plants, we identified a mutant exhibiting dwarfism and an early-senescence leaf phenotype, termed dwarf and early-senescence leaf (del1). Histological analysis showed that the abnormal growth was caused by a reduction in cell number. Further investigation revealed that the decline in cell number in del1 was affected by the cell cycle. Physiological analysis, transmission electron microscopy, and TUNEL assays showed that leaf senescence was triggered by the accumulation of reactive oxygen species...
April 28, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28439985/the-utility-of-mass-fix-to-detect-and-monitor-monoclonal-proteins-in-the-clinic
#12
Paolo Milani, David L Murray, David R Barnidge, Mindy C Kohlhagen, John R Mills, Giampaolo Merlini, Surendra Dasari, Angela Dispenzieri
The detection and quantification of monoclonal-proteins (M-proteins) are necessary for the diagnosis and evaluation of response in plasma cell dyscrasias. Immunoglobulin enrichment-coupled with matrix-assisted laser desorption ionization time-of-flight mass-spectrometry (MASS-FIX) is a simple and inexpensive method to identify M-proteins, but its clinical generalizability has not yet been elucidated. We compared MASS-FIX to protein electrophoresis (PEL), serum/urine immunofixation-electrophoresis (IFE) and quantitative serum free-light chain (FLC) for the identification of M-proteins in different clinical diagnoses...
April 25, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28433395/distribution-enrichment-and-source-of-heavy-metals-in-rizhao-offshore-area-southeast-shandong-province
#13
Hongying Song, Jinqing Liu, Ping Yin, Yong Zhang
50 surface sediments were collected from Rizhao offshore area to determine heavy metals (Cu, Pb, Zn, Cr, Cd, As, Hg) pollution. High heavy metal values were located near the two ports in the north and south study areas, which was consistent with the distribution of fine-grained sediments. According to threshold effect level (TEL) and probable effect level (PEL), Cu and As had occasionally adverse biological effects on the aquatic ecosystems. The enrichment factor (EF) values showed that most of the study area was moderate or moderately severe enrichment for As, and minor enrichment for Pb, but Hg was only moderately enriched in the river estuaries...
April 19, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28430817/kaposi-sarcoma-herpesvirus-kshv-latency-associated-nuclear-antigen-lana-recruits-components-of-the-mrn-mre11-rad50-nbs1-repair-complex-to-modulate-an-innate-immune-signaling-pathway-and-viral-latency
#14
Giuseppe Mariggiò, Sandra Koch, Guigen Zhang, Magdalena Weidner-Glunde, Jessica Rückert, Semra Kati, Susann Santag, Thomas F Schulz
Kaposi Sarcoma Herpesvirus (KSHV), a γ2-herpesvirus and class 1 carcinogen, is responsible for at least three human malignancies: Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL) and Multicentric Castleman's Disease (MCD). Its major nuclear latency protein, LANA, is indispensable for the maintenance and replication of latent viral DNA in infected cells. Although LANA is mainly a nuclear protein, cytoplasmic isoforms of LANA exist and can act as antagonists of the cytoplasmic DNA sensor, cGAS. Here, we show that cytosolic LANA also recruits members of the MRN (Mre11-Rad50-NBS1) repair complex in the cytosol and thereby inhibits their recently reported role in the sensing of cytoplasmic DNA and activation of the NF-κB pathway...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28407694/molecular-mechanisms-of-activating-c-met-in-kshv-primary-effusion-lymphoma
#15
Bao Quoc Lam, Lu Dai, Li Li, Jing Qiao, Zhen Lin, Zhiqiang Qin
The oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) is a principal causative agent of primary effusion lymphoma (PEL), which is mostly seen in immunosuppressed patients. PEL is a rapidly progressing malignancy with a median survival time of approximately 6 months even under the conventional chemotherapy. We recently report that the hepatocyte growth factor (HGF)/c-MET pathway is highly activated in PEL cells and represents a promising therapeutic target (Blood. 2015;126(26):2821-31). However, the underlying mechanisms of c-MET activation within PEL cells remain largely unknown...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28405925/a-survey-of-metal-concentrations-in-marine-sediment-cores-in-the-vicinity-of-an-old-mercury-mining-area-in-karaburun-aegean-sea
#16
Ebru Yesim Ozkan, Hasan Baha Buyukisik, Aynur Kontas, Mert Turkdogan
The aim of this study was to assess the historical trends of metal concentrations in coastal sediments in the vicinity of an inactive mining area, find background values and contamination levels of metals around the Karaburun peninsula, and then search for other sources of mercury in marine sediment cores using multivariate statistical analysis and report the potential ecological risks from that metal contamination. Surface sediment samples were taken from seven stations. Water depths were less than 20 m (coastal area) at stations KB07 and KB08...
April 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28399009/primary-effusion-lymphoma-current-concepts-and-management
#17
Nivedita Arora, Arjun Gupta, Navid Sadeghi
PURPOSE OF REVIEW: To summarize the current epidemiology, management, and outcomes of primary effusion lymphoma (PEL) and highlight possible future research efforts. RECENT FINDINGS: Cyclophosphamide, doxorubicin, vincristine, prednisone-based chemotherapy regimens alone or in combination with immunomodulatory agents (e.g., lenalidomide), or proteasome inhibitors (e.g., bortezomib), or targeted therapies, are commonly used to treat PEL. Highly active antiretroviral therapy should be continued or initiated in patients with HIV infection...
April 8, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28396094/ym155-induces-apoptosis-through-proteasome-dependent-degradation-of-mcl-1-in-primary-effusion-lymphoma
#18
Yuki Kojima, Fumihiko Hayakawa, Takanobu Morishita, Keiki Sugimoto, Yuka Minamikawa, Mizuho Iwase, Hideyuki Yamamoto, Daiki Hirano, Naoto Imoto, Kazuyuki Shimada, Seiji Okada, Hitoshi Kiyoi
Primary effusion lymphoma (PEL) is a lymphoma that shows malignant effusion in body cavities without contiguous tumor masses and has a very poor prognosis. We recently developed a novel drug screening system using patient-derived xenograft (PDX) cells that maintained the primary cell phenotype better than cell lines. This screening is expected to discover anti-tumor drugs that have been overlooked by conventional screening using cell lines. We herein performed this screening to identify new therapeutic agents for PEL...
June 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28393364/sirt1-and-ampk-pathways-are-essential-for-the-proliferation-and-survival-of-primary-effusion-lymphoma-cells
#19
Meilan He, Brandon Tan, Karthik Vasan, Hongfeng Yuan, Fan Cheng, Suzane Ramos da Silva, Chun Lu, Shou-Jiang Gao
Primary effusion lymphoma (PEL) is a rare and aggressive B-cell lymphoma with a dismal prognosis caused by infection of Kaposi's sarcoma-associated herpesvirus. Despite the findings that numerous viral genes and cellular pathways are essential for the proliferation and survival of PEL cells, there is currently no effective therapeutic treatment for PEL. Here, we report that the metabolic sensor SIRT1 is functionally required for sustaining the proliferation and survival of PEL cells. Knockdown of SIRT1 with specific shRNAs or inhibition of SIRT1 with an inhibitor (Tenovin-6) induced cell cycle arrest and apoptosis in PEL cells...
April 9, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28388309/a-comprehensive-assessment-of-exposures-to-respirable-dust-and-silica-in-the-taconite-mining-industry
#20
Jooyeon Hwang, Gurumurthy Ramachandran, Peter C Raynor, Bruce H Alexander, Jeffrey H Mandel
This study assessed the present-day levels (year 2010-2011) of exposure to respirable dust (RD) and respirable silica (RS) in taconite mines and evaluated how the mining process influences exposure concentrations. Personal samples (n = 679) were collected to assess exposure levels of workers to RD and RS at six mines in the Mesabi Iron Range of Minnesota. The RD and RS concentrations were measured using the National Institute for Occupational Safety and Health (NIOSH) 0600 and NIOSH 7500, respectively. Between-mine, between-SEG (similar exposure groups), within-SEG, and within-worker components of variability for RD and RS exposures were estimated using a two- or three-way nested random-effects ANOVA model...
May 2017: Journal of Occupational and Environmental Hygiene
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