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Shinichiro Ota, Yuji Fujikura, Takayuki Yamamoto, Yohei Maki, Atsushi Kurokawa, Takuya Maeda, Soichiro Kanoh, Akihiko Kawana
Primary effusion lymphoma (PEL) is a rare subtype of large B-cell lymphoma associated with human herpesvirus-8. Most cases are co-infected with Epstein-Barr virus (EBV). The prognosis of PEL is extremely poor and no optimal treatment regimen has been established. We report a case of EBV-negative PEL in a 49-year-old human immunodeficiency virus-positive man, presenting with massive bilateral pleural effusion.
February 14, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Satoshi Otani, Kazufumi Hiramatsu, Kazuhiko Hashinaga, Kosaku Komiya, Kenji Umeki, Kenji Kishi, Jun-Ichi Kadota
Pseudomonas aeruginosa exhibits the biofilm mode of growth and causes chronic as well as acute infections in humans. Several reports have shown that the treatments with sub-minimum inhibitory concentrations (sub-MICs) of antimicrobial agents influence biofilm formation by P. aeruginosa. The antibiotic ceftazidime (CAZ) is used to treat P. aeruginosa infections, but few studies have examined the effects of β-lactams on biofilm formation by P. aeruginosa. In this study, we investigated the role of sub-MICs of CAZ in the formation of P...
February 12, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Elżbieta J Pels
BACKGROUND: Oral mucositis is a problem occurring within the oral cavity, which is the most difficult to deal with during anti-tumor treatment. The first symptom reported by the patient is discomfort. Salivary immunoglobulins play an important role in pathological processes occurring in the oral cavity. OBJECTIVES: The study objective was to assess the occurrence of oral mucositis and to assess changes in the saliva IgA, IgG, and IgM concentration in children with acute lymphoblastic leukemia during antitumor treatment...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Peter Muturi, Junping Yu, Junhua Li, Mengwei Jiang, Alice Nyambura Maina, Samuel Kariuki, Francis B Mwaura, Hongping Wei
AIMS: Isolation and characterisation of pectolytic bacteria associated with soft rot disease of potatoes in Nakuru, Kenya, to provide basis for the development of disease control measures. METHODS AND RESULTS: Potato tubers showing symptoms of soft rot were collected from different farms in Molo and Mau Narok regions within Nakuru county. Isolation was done using crystal violet pectate medium (CVPM). Out of 71 isolates that showed growth on crystal violet pectate medium, pathogenicity tests revealed that 36 of them had the ability to macerate tissues of potato tubers...
February 13, 2018: Journal of Applied Microbiology
Wânia Duleba, Andreia C Teodoro, Jean-Pierre Debenay, Maria Virgínia Alves Martins, Silas Gubitoso, Leonardo Antônio Pregnolato, Laura Misailidis Lerena, Silvio Miranda Prada, José Eduardo Bevilacqua
The Dutos e Terminais do Centro Sul (DTCS) is one of the largest petroleum terminals of the South America located in the São Sebastião Channel (SSC) on the southeastern Brazilian coast. The aims of this study were to compare the sediment quality near the DTCS with that of several sites in the SSC region including the Araçá (AR) domestic sewage outfall and to assess the efficiency of the DTCS wastewater treatment plant. To achieve these goals, textural, geochemical, and living benthic foraminifera results were analyzed for the DTCS, AR, and SSC regions...
2018: PloS One
Gang Sun, Limei Xu, Nicolas Giovambattista
We study the potential energy landscape (PEL) of a waterlike monatomic liquid that exhibits a liquid-liquid phase transition (LLPT) and glass-glass transformation (GGT). We identify two anomalous features of the PEL that give origin to both phenomena. Specifically, during the pressure-induced LLPT and GGT, (i) the inherent structures (IS) energy becomes a concave function of volume, and (ii) the IS pressure exhibits a van der Waals-like loop. We argue that features (i) and (ii) imply that the GGT is a (nonequilibrium) first-order phase transition, analogous to the LLPT...
January 19, 2018: Physical Review Letters
Hye Ryun Yu, Yeong Jun Kim, Hye-Ra Lee
Primary effusion lymphoma (PEL), strongly linked with latent infection of Kaposi's sarcoma-associated herpesvirus (KSHV), constitutively expresses cellular interferon regulatory factor 4 (IRF4) while suppressing the expression of B cell lymphoma 6 (BCL6). Recently, it was shown that IRF4, a key transcriptional repressor of BCL6, might be a pivotal regulator of KSHV for balancing between latency and its reactivation in PEL cells. However, the action of the BCL6-IRF4 transcription factor axis during KSHV's life cycle is not clear...
February 1, 2018: Biochemical and Biophysical Research Communications
Xiaochen Yuan, Fang Tian, Chenyang He, Geoffrey B Severin, Christopher M Waters, Quan Zeng, Fengquan Liu, Ching-Hong Yang
Dickeya dadantii 3937 secretes pectate lyases (Pels) to degrade the plant cell wall. Previously, we have demonstrated that EGcpB and EcpC function as cyclic-di-GMP (c-di-GMP) specific phosphodiesterases (PDEs) to positively regulate Pel production. However, the diguanylate cyclase (DGC) responsible for the synthesis of c-di-GMP and dichotomously regulation of Pel has remained a mystery. Here, we identified GcpA is the dominant DGC to negatively regulate Pel production by specifically repressing pelD gene expression...
February 1, 2018: Molecular Plant Pathology
Henri Gruffat, Evelyne Manet
Kaposi's sarcoma human herpesvirus (KSHV) is the etiologic agent of primary effusion lymphoma (PEL) in which Epstein-Barr virus (EBV) is also very often present. By using a humanized mouse model, Pr. Münz's team has been able to demonstrate that EBV/KSHV co-infection increases KSHV persistence and cell transformation through the stimulation of EBV replication. This is the first model of PEL in small animals, opening up exciting prospects for future studies on this unique lymphoma.
January 2018: Médecine Sciences: M/S
Fei Li, Minsi Xiao, Jingdong Zhang, Chaoyang Liu, Zhenzhen Qiu, Ying Cai
Spatial concentrations and chemical fractions of heavy metals (Cr, Cu, Pb, Zn and Cd) in 16 sampling sites from the Honghu Lake were investigated using an atomic absorption spectrophotometer and optimized BCR (the European Community Bureau of Reference) three-stage extraction procedure. Compared with the corresponding probable effect levels (PELs), adverse biological effects of the studied five sediment metals decreased in the sequence of Cr > Cu > Zn > Pb > Cd. Geo-accumulation index (Igeo) values for Cr, Cu, Pb and Zn in each sampling site were at un-contamination level, while the values for Cd varied from un-contamination level to moderate contamination level...
January 26, 2018: International Journal of Environmental Research and Public Health
Sinosh Skariyachan, Vaishnavi Sneha Sridhar, Swathi Packirisamy, Supreetha Toplar Kumargowda, Sneha Basavaraj Challapilli
Pseudomonas aeruginosa, a Gram-negative, rod-shaped bacterium causes widespread diseases in humans. This bacterium is frequently related to nosocomial infections such as pneumonia, urinary tract infections (UTIs) and bacteriaemia especially in immunocompromised patients. The current review focuses on the recent perspectives on biofilms formation by these bacteria. Biofilms are communities of microorganisms in which cells stick to each other and often adhere to a surface. These adherent cells are usually embedded within a self-produced matrix of extracellular polymeric substance (EPS)...
January 19, 2018: Folia Microbiologica
Qiwang Xiang, Hyunwoo Ju, Qian Li, Szu-Chieh Mei, Daming Chen, Young Bong Choi, John Nicholas
Human herpesvirus 8 (HHV-8) encodes four viral interferon regulatory factors (vIRFs 1-4) that likely function to suppress innate immune and cellular stress responses through inhibitory interactions with various cellular proteins involved in these activities. It is notable that vIRFs 1 and 4 have been reported to interact with the deubiquitinase USP7, substrates of which include p53 and p53-targeting and destabilizing ubiquitin E3 ligase MDM2. Structural studies of vIRF-1 and vIRF-4 USP7-binding sequences in association with USP7 have been reported; both involve interactions with N-terminal domain residues of USP7, via EGPS and ASTS motifs in vIRF-1 and vIRF-4, respectively, but vIRF-4 residues also contact the catalytic site...
January 17, 2018: Journal of Virology
Rob M G van Bommel, Adri C Voogd, Joost Nederend, Wikke Setz-Pels, Marieke W J Louwman, Luc J Strobbe, Dick Venderink, Vivianne C G Tjan-Heijnen, Lucien E M Duijm
BACKGROUND: Detected by screening mammography, bilateral breast cancer has a different pathological profile compared to unilateral breast cancer. We investigated the incidence of bilateral interval breast cancers and compared their characteristics with those of unilateral interval breast cancers. METHODS: We included all 468,720 screening mammograms of women who underwent biennial screening mammography in the South of the Netherlands between January 2005 and January 2015...
January 3, 2018: Breast: Official Journal of the European Society of Mastology
Kevin Pels, Paige Dickson, Hongchan An, Thomas Kodadek
We demonstrate that the Knoevenagel condensation can be exploited in combinatorial synthesis on the solid phase. Condensation products from such reactions were structurally characterized, and their Michael reactivity with thiol and phosphine nucleophiles is described. Cyanoacrylamides were previously reported to react reversibly with thiols, and notably, we show that dilution into low pH buffer can trap covalent adducts which are isolable via chromatography. Finally, we synthesized both traditional and DNA-encoded one-bead, one-compound libraries containing cyanoacrylamides as a source of cysteine-reactive, reversibly covalent protein ligands...
January 3, 2018: ACS Combinatorial Science
Yanfeng Zhang, Yuwei Han, Jinxi Yang, Lingyan Zhu, Wenjue Zhong
The occurrence, toxicities, and ecological risks of five heavy metals (Pb, Cu, Cd, Zn and Ni) in the sediment of Taihu Lake were investigated in this study. To evaluate the toxicities caused by the heavy metals, the toxicities induced by organic contaminants and ammonia in the sediments were screened out with activated carbon and zeolite. The toxicities of heavy metals in sediments were tested with benthic invertebrates (tubificid and chironomid). The correlations between toxicity of sediment and the sediment quality guidelines (SQGs) derived previously were evaluated...
December 2017: Journal of Environmental Sciences (China)
Evren Tunca, Mehmet Aydın, Ülkü Alver Şahin
The aim of this study is an assessment of metal pollution levels in Aegean Sea sediment. Sediment samples collected from 7 different locations (Yeniköy, Edremit, Ayvalık, Dikili, Aliağa, Hekimadası, and Ildır) along the northern Mediterranean region of Turkey were investigated for 11 elements (Cu, Fe, Zn, V, Cd, Ni, As, Pb, Mn, Co, and Cr). Graphite furnace atomic absorption spectrophotometry (GFAAS) and flame atomic absorption spectrophotometry (FAAS) were used for elemental analysis. The findings were evaluated with sediment assessment methods by taking two different values as a reference and then investigating the adverse biological effects of elemental profiles on living organisms...
December 27, 2017: Environmental Science and Pollution Research International
N S Kadavath Meethal, D Mazumdar, R Asokan, M Panday, J van der Steen, K A Vermeer, H G Lemij, R J George, J J M Pel
BACKGROUND: Eye Movement Perimetry (EMP) uses Saccadic Eye Movement (SEM) responses for visual field evaluation. Previous studies have demonstrated significant delay in initiation of SEMs among glaucoma patients in comparison with healthy subjects. The aim of the current study was to develop an EMP-based screening grid to identify glaucomatous visual field defects. METHODS: An interactive test consisting of 36 locations and two stimulus contrasts (162 cd/m2 and 190 cd/m2 on a background of 140 cd/m2) was evaluated in 54 healthy subjects and 50 primary glaucoma patients...
December 28, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
A Pels, L C Kenny, Z Alfirevic, P N Baker, Peter von Dadelszen, C Gluud, C T Kariya, B W Mol, A T Papageorghiou, A G van Wassenaer-Leemhuis, W Ganzevoort, K M Groom
BACKGROUND: Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes...
December 28, 2017: BMC Pregnancy and Childbirth
Martin Muller, David Vehlow, Bernhard Torger, Birgit Urban
BACKGROUND: In this contribution an overview is given on own work concerning drug loaded polyelectrolyte complex (PEC) nanoparticles (NP) used to functionalize bone substitute materials (BSM) for the therapy of bone defects associated with systemic bone diseases. In this context drug loaded PEC NP have certain advantages, which are exemplarily summarized herein. METHODS: Concerning preparative methods PEC NP were fabricated by controlled mixing of polycation and polyanion solutions and integration of charged drugs during and after mixing...
December 12, 2017: Current Pharmaceutical Design
Ana Maria Bago Rodriguez, Bernard P Binks, Tomoko Sekine
We investigate the possibility of stabilising oil-water emulsions from the polyelectrolyte complexes (PEC) obtained in mixtures of a strong cationic polyelectrolyte (poly(diallyldimethylammonium chloride), PDADMAC) and a weak anionic one (poly(acrylic acid)sodium salt, PAANa). Unlike other previous work however, both polyelectrolytes (PEL) are chosen as they are completely water-soluble and possess no surface activity when present alone over nearly all the pH range. In water, the effects of PEL concentration, PEL mixing ratio and pH on the formation of PEC are studied in detail...
December 12, 2017: Soft Matter
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