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blood urea nitrogen

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https://www.readbyqxmd.com/read/28087157/the-association-of-blood-urea-nitrogen-levels-with-mortality-in-acute-pulmonary-embolism
#1
Mustafa A Tatlisu, Adnan Kaya, Muhammed Keskin, Sahin Avsar, Mehmet Bozbay, Kiymet Tatlisu, Mehmet Eren
BACKGROUND: The aim of this study was to investigate the association of BUN levels with in-hospital and long-term adverse clinical outcomes in acute pulmonary embolism (APE) patients treated with tissue-plasminogen activator (t-PA). METHODS: This retrospective study included 252 consecutive confirmed APE patients treated with t-PA. An admission BUN of 34.5 mg/dL was identified through an ROC analysis as an optimal cutoff value to predict the in-hospital mortality with 85% sensitivity and 91% specificity (AUC: 0...
December 29, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/28080899/health-and-nutritional-assessment-of-free-ranging-eastern-indigo-snakes-drymarchon-couperi-in-georgia-united-states
#2
S Emmanuelle Knafo, Terry M Norton, Mark Mitchell, Dirk J Stevenson, Natalie Hyslop, Robert Poppenga, Marcie Oliva, Tai Chen, Carolyn Cray, Samantha E J Gibbs, Lance Durden, Nancy Stedman, Stephen Divers, Ellen Dierenfeld
Clinical pathology and nutritional parameters are useful in evaluating and monitoring threatened and endangered wildlife populations, but reference ranges for most snake species are lacking. From 2001 to 2005, health assessments were performed on 58 eastern indigo snakes (EIS) (Drymarchon couperi) captured in the wild in southeastern Georgia, United States. Health and nutritional assessments performed included hematology, serum biochemistry, fat-soluble vitamins, heavy metals, pesticide contaminants, parasitology, and surveys of other pathogens...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28078531/yeast-mixture-of-liquid-beer-and-cassava-pulp-with-rice-straw-for-the-growth-of-dairy-heifers
#3
Sukanya Kamphayae, Hajime Kumagai, Patima Butcha, Viroj Ritruechai, Supachai Udchachon
This study was conducted to determine the effects of mixtures of liquid brewer's yeast (LBY) and cassava pulp (CVP) with rice straw (RS) on feed intake, digestibility, rumen fermentation, and growth of dairy heifers. Sixteen Holstein crossbred heifers (13.8 ± 1.6 months old, 210 ± 23 kg body weight (BW)) were randomly allocated to four feeding treatments with four replications, which were 0:0:100 (RS), 0:70:30 (0%LBY), 20:50:30 (20%LBY), and 50:20:30 (50%LBY), respectively, for LBY/CVP/RS on a fresh matter basis...
January 11, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28078430/blood-urea-nitrogen-to-serum-creatinine-ratio-is-an-accurate-predictor-of-outcome-in-diarrhea-associated-hemolytic-uremic-syndrome-a-preliminary-study
#4
Werner Keenswijk, Jill Vanmassenhove, Ann Raes, Evelyn Dhont, Johan Vande Walle
: Diarrhea-associated hemolytic uremic syndrome (D+HUS) is a common thrombotic microangiopathy during childhood and early identification of parameters predicting poor outcome could enable timely intervention. This study aims to establish the accuracy of BUN-to-serum creatinine ratio at admission, in addition to other parameters in predicting the clinical course and outcome. Records were searched for children between 1 January 2008 and 1 January 2015 admitted with D+HUS. A complicated course was defined as developing one or more of the following: neurological dysfunction, pancreatitis, cardiac or pulmonary involvement, hemodynamic instability, and hematologic complications while poor outcome was defined by death or development of chronic kidney disease...
January 11, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28078262/the-leaf-of-diospyros-kaki-thumb-ameliorates-renal-oxidative-damage-in-mice-with-type-2-diabetes
#5
Myung-Sook Choi, Mi Ji Jeong, Yong Bok Park, Sang Ryong Kim, Un Ju Jung
Diabetic kidney disease is the most common and severe chronic complication of diabetes. The leaf of Diospyros kaki Thumb (persimmon) has been commonly used for herbal tea and medicinal purposes to treat a variety of conditions, including hypertension and atherosclerosis. However, the effect of persimmon leaf on kidney failure has not been investigated. This study aimed to examine the role of persimmon leaf in protecting the diabetes-associated kidney damage in a mouse model of type 2 diabetes. Mice were fed either a normal chow diet with or without powered persimmon leaf (5%, w/w) for 5 weeks...
December 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28075469/urinary-kidney-injury-molecule%C3%A2-1-as-an-early-diagnostic-biomarker-of-obstructive-acute-kidney-injury-and-development-of-a-rapid-detection-method
#6
Yingli Jin, Xiaona Shao, Bo Sun, Chunsheng Miao, Zhengqiang Li, Yan Shi
The aim of the present study was to investigate whether urinary kidney injury molecule‑1 (KIM‑1) presents a suitable early diagnostic biomarker of obstructive nephropathy‑induced acute kidney injury (AKI), and to develop a rapid detection method for urinary KIM‑1. Obstructive AKI was induced in an experimental rat model by a unilateral ureteral obstruction (UUO) operation. Macro‑ and micromorphological kidney alterations were determined by visual observation and hematoxylin and eosin (HE) staining, respectively...
January 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28068558/targeted-next-generation-sequencing-of-the-entire-vitamin-d-receptor-gene-reveals-polymorphisms-correlated-with-vitamin-d-deficiency-among-older-filipino-women-with-and-without-fragility-fracture
#7
Mark Pretzel Zumaraga, Paul Julius Medina, Juan Miguel Recto, Lauro Abrahan, Edelyn Azurin, Celeste C Tanchoco, Cecilia A Jimeno, Cynthia Palmes-Saloma
This study aimed to discover genetic variants in the entire 101 kB vitamin D receptor (VDR) gene for vitamin D deficiency in a group of postmenopausal Filipino women using targeted next generation sequencing (TNGS) approach in a case-control study design. A total of 50 women with and without osteoporotic fracture seen at the Philippine Orthopedic Center were included. Blood samples were collected for determination of serum vitamin D, calcium, phosphorus, glucose, blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase and as primary source for targeted VDR gene sequencing using the Ion Torrent Personal Genome Machine...
December 21, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28067935/hepatitis-b-vaccination-in-haemodialysis-patients-an-underestimated-problem-factors-influencing-immune-responses-in-ten-years-of-observation-in-an-italian-haemodialysis-centre-and-literature-review
#8
E Cordova, I Miglia, F Festuccia, M G Sarlo, G Scornavacca, G Punzo, P Menè, C Fofi
OBJECTIVES: Despite universal infection control precautions, the risk of hepatitis B virus (HBV) infection in patients on chronic haemodialysis (HD) remains high. For this reason anti-HBV vaccination is recommended in these subjects. In hemodialyzed patients vaccinal response is often suboptimal and it's not clear what factors may influence it. STUDY DESIGN: The aim of our study is to assess the influence of some clinical and laboratory factors on seroconversion rate after anti HBV vaccination in a cohort of patients on maintenance HD...
January 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28064632/protective-effects-of-apigenin-and-myricetin-against-cisplatin-induced-nephrotoxicity-in-mice
#9
Samar M Hassan, Marwa M Khalaf, Sawsan A Sadek, Amira M Abo-Youssef
CONTEXT: Currently, the outcomes of the use of cisplatin in cancer therapy is limited by nephrotoxicity. OBJECTIVE: This study aims to investigate the nephroprotective role of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice. MATERIALS AND METHODS: Adult female Wistar Albino mice were divided into eight groups (n = 8). Group I served as normal control. Groups II, III and IV received apigenin (3 mg/kg, i.p.), myricetin (3 mg/kg, i...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28063240/effect-of-feeding-complete-feed-block-containing-rumen-protected-protein-non-protein-nitrogen-and-rumen-protected-fat-on-improving-body-condition-and-carcass-traits-of-cull-ewes
#10
R S Bhatt, A Sahoo
Nutrient utilization, body condition and carcass traits of cull ewes were studied in three dietary regimens based on complete feed block (CFB) feeding to control (C) with rumen protected protein (RPP), CU [RPP + urea (6 g/kg)] and CUF [RPP + urea + rumen protected fat (RPF; 40 g/kg)]. The RPP component (g/kg) in C had 1% formaldehyde-treated soy flakes 50, mustard cake 50 and sesame cake 30. The mustard and sesame cakes were replaced with urea on equivalent N basis in CU and CUF. The ewes were offered ad libitum CFB composed (g/kg) of concentrate 650, roughage 300 and molasses 50...
January 7, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28060032/validation-of-a-model-for-predicting-pressure-injury-risk-in-patients-with-vascular-diseases
#11
Tonya Moyse, Jacqueline Bates, Matthew Karafa, Angela Whitman, Nancy M Albert
PURPOSE: The purpose of this study was to validate a 10-factor model of risk factors for hospital-acquired pressure injury (HAPI) risk in patients with vascular disease. SUBJECTS AND SETTING: Medical reviews identified 800 patients from a 1063 admissions from a 1400 bed quarternary care hospital in the midwestern United States. DESIGN: Retrospective review of medical records. METHODS: Medical records of consecutive patients treated during an 18-month period on a medical-surgical vascular progressive care unit were reviewed...
January 3, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28058588/the-hypoglycemic-hypolipidemic-and-anti-diabetic-nephritic-activities-of-zeaxanthin-in-diet-streptozotocin-induced-diabetic-sprague-dawley-rats
#12
Ling Kou, Mingzhao Du, Chaopu Zhang, Zhiyin Dai, Xuan Li, Baohai Zhang
Zeaxanthin (ZA), an important compound found in Lycium barbarum, shows various pharmacodynamic effects. In our present study, a high-fat, high-sucrose diet and streptozotocin (STZ)-induced diabetic rat model was used to investigate the antidiabetic activities of ZA. After a 4-week administration of 200 and 400 mg/kg of ZA and 100 mg/kg of metformin hydrochloride, various blood biochemical indexes were detected. ZA strongly normalized the reduced bodyweight and enhanced fasting blood glucose in diabetic rats...
January 5, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28056664/protective-effect-of-sfe-co2-of-ligusticum-chuanxiong-hort-against-d-galactose-induced-injury-in-the-mouse-liver-and-kidney
#13
Zhizhun Mo, Yuhong Liu, Cailan Li, Lieqiang Xu, Lingling Wen, Yanfang Xian, Zhixiu Lin, Janis Ya-Xian Zhan, Jiannan Chen, Fangfang Xu, Zi-Ren Su
This study was designed to explore how supercritical fluid CO2 extract of Ligusticum chuanxiong Hort (CX) protect mouse liver and kidney from D-galactose induced injury. The antioxidant capacity of CX was confirmed both in vitro and in vivo. The D-galactose induced malondialdehyde increasing was attenuated by CX, as well as the increases of aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen and creatinine level. In addition, the activities of antioxidant enzymes were markedly renewed, and the genes expressions of these enzymes were up-regulated in CX groups...
January 5, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28053613/diallyl-disulfide-attenuates-acetaminophen-induced-renal-injury-in-rats
#14
Jin-Young Shin, Ji-Hee Han, Je-Won Ko, Sung-Hyeuk Park, Na-Rae Shin, Tae-Yang Jung, Hyun-A Kim, Sung-Hwan Kim, In-Sik Shin, Jong-Choon Kim
This study investigated the protective effects of diallyl disulfide (DADS) against acetaminophen (AAP)-induced acute renal injury in male rats. We also investigated the effects of DADS on kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL), which are novel biomarkers of nephrotoxicity in renal tissues, in response to AAP treatment. The following four experimental groups were evaluated: (1) vehicle control, (2) AAP (1,000 mg/kg), (3) AAP&DADS, and (4) DADS (50 mg/kg/day). AAP treatment caused acute kidney injury evidenced by increased serum blood urea nitrogen (BUN) levels and histopathological alterations...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053566/protective-effect-of-olive-and-juniper-leaves-extracts-on-nephrotoxicity-induced-by-thioacetamide-in-male-mice
#15
Atef M Al-Attar, Ali A Alrobai, Daklallah A Almalki
This study, for the first time, evaluates the effect of olive and juniper leaves extracts and their combination on thioacetamide (TAA)-induced nephrotoxicity in male mice. The experimental mice were divided into eight groups. Group 1 was served as control. Group 2 was exposed to TAA. Group 3 was treated with TAA and olive leaves extract. Group 4 was subjected to TAA and juniper leaves extract. Group 5 was exposed to TAA and olive and juniper leaves extracts. Groups 6, 7 and 8 were treated with olive, juniper, and olive and juniper leaves extracts respectively...
January 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28053556/assessment-of-the-effect-of-antiretroviral-therapy-on-renal-and-liver-functions-among-hiv-infected-patients-a-retrospective-study
#16
Habtamu Wondifraw Baynes, Birhanemeskel Tegene, Mikiyas Gebremichael, Gebrehawaria Birhane, Wabe Kedir, Belete Biadgo
BACKGROUND: The emergence of highly active antiretroviral therapy (HAART) has dramatically improved quality of life in prolonging survival of human immunodeficiency virus (HIV)-infected patients on treatment in developed as well as developing countries. However, the main shortcoming of HAART in long-term use is its potential to cause liver and kidney derangements that may be life threatening. The drugs are actively accumulated in the proximal renal tubule resulting in functional disturbance with mitochondrial injury being one of the most important targets recognized...
2017: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/28052874/inhibition-of-hdac6-protects-against-rhabdomyolysis-induced-acute-kidney-injury
#17
Shi Yingfeng, Xu Liuqing, Tang Jinhua, Fang Lu, Ma Shuchen, Ma Xiaoyan, Nie Jing, Pi Xiaoling, Qiu Andong, Zhuang Shougang, Liu Na
Histone deacetylase 6 (HDAC6) inhibition has been reported to protect against ischemic stroke and prolong survival after sepsis in animal models. However, it remains unknown whether HDAC6 inhibition offers a renoprotective effect after acute kidney injury (AKI). In this study, we examined the therapeutic effect of tubastatin A (TA), a highly selective inhibitor of HDAC6, on AKI in a murine model of glycerol (GL) injection-induced rhabdomyolysis. Following GL injection, the mice developed severe acute tubular injury as indicated by renal dysfunction, expression of neutrophil gelatinase-associated lipocalin (NGAL), an injury marker of renal tubules and increase of TUNEL positive tubular cells...
January 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28044266/a-comparative-effectiveness-study-of-renal-parameters-between-imidapril-and-amlodipine-in-patients-with-hypertension-a-retrospective-cohort-study
#18
Yayoi Nishida, Yasuo Takahashi, Kotoe Tezuka, Satoshi Takeuchi, Tomohiro Nakayama, Satoshi Asai
INTRODUCTION: Imidapril is an angiotensin converting enzyme inhibitor (ACEI) that is frequently used as an antihypertensive drug in Japan. Although ACEIs are known to have adverse effects of decreasing glomerular filtration rate (GFR) and causing hyperkalemia, there are very few clinical data on the long-term effect of imidapril on glomerular function. We conducted a retrospective cohort study using a clinical database to evaluate and compare the long-term effects of imidapril and amlodipine on renal parameters in Japanese hypertensive patients in routine clinical practice...
January 2, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28041730/effects-of-cinnamaldehyde-or-monensin-on-performance-of-weaned-holstein-dairy-heifers
#19
C E Chapman, H Chester-Jones, D Ziegler, J A Clapper, P S Erickson
The objective of this 70-d study was to determine the effects of the essential oil cinnamaldehyde compared with the ionophore monensin on performance of weaned Holstein dairy heifers. Eighty-four Holstein dairy heifers (91 ± 3.33 d of age; 109 ± 7.55 kg) were housed in a naturally ventilated curtain side-wall, straw-bedded barn in 12 pens with 7 heifers/pen (3.98 m(2)/head). Heifers were randomly assigned to 1 of 4 treatments in a completely randomized design: (1) control (CON; carrier, 908 g of ground corn), (2) monensin sodium [MON; 1 mg/kg of body weight (BW) + carrier], (3) cinnamaldehyde (CIN1; 1 mg/kg of BW + carrier), or (4) cinnamaldehyde (CIN2; 2 mg/kg of BW + carrier)...
December 29, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/28031705/earlier-nephrology-consultation-may-not-be-associated-with-improved-short-term-survival-of-acute-kidney-injury-in-very-elderly-men
#20
Qinglin Li, Meng Zhao, Jing Du, Xiaodan Wang
OBJECTIVES: A delayed nephrology consultation (NC) may be associated with a poor prognosis in acute kidney injury (AKI) patients. The aims of this study were to compare the clinical and laboratory characteristics of elderly AKI patients evaluated and not evaluated by nephrologists and to generate a hypothesis regarding the relationship between the timing of the NC and 90-day outcomes. METHODS: From 2007 to 2015, this study explored associations among the presence and timing of NC with the non-intensive care unit stay and 90-day mortality in elderly AKI patients at the Geriatric Department of the Chinese People's Liberation Army General Hospital...
2017: Clinical Interventions in Aging
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