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apnoea of preterm

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https://www.readbyqxmd.com/read/27888413/improving-manual-oxygen-titration-in-preterm-infants-by-training-and-guideline-implementation
#1
Henriëtte A van Zanten, Steffen C Pauws, Evelien C Beks, Ben J Stenson, Enrico Lopriore, Arjan B Te Pas
: To study oxygen saturation (SpO2) targeting before and after training and guideline implementation of manual oxygen titration, two cohorts of preterm infants <30 weeks of gestation needing respiratory support and oxygen therapy were compared. The percentage of the time spent with SpO2 within the target range (85-95%) was calculated (%SpO2-wtr). SpO2 was collected every minute when oxygen is >21%. ABCs where oxygen therapy was given were identified and analyzed. After training and guideline implementation the %SpO2-wtr increased (median interquartile range (IQR)) 48...
November 26, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27800071/neonatal-transport-practices-in-ibadan-nigeria
#2
Muhydeen Abiodun Abdulraheem, Olukemi Oluwatoyin Tongo, Adebola Emmanuel Orimadegun, Olukayode Felix Akinbami
INTRODUCTION: Neonatal transport involves moving sick neonates in optimal conditions to ensure good outcomes. It is well organized in most developed countries but receives little attention in developing countries where the highest burden of neonatal mortality exists and a large number of newborns require referrals daily for better medical care. This study sought to evaluate the modes of transport, pre- and intra-transport care of neonates referred to the University College Hospital (UCH), Ibadan, Nigeria...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27681352/atypical-presentation-of-acute-fulminant-neonatal-necrotising-enterocolitis-diagnostic-superiority-of-sonographic-evaluation-over-plain-radiography-of-abdomen
#3
Vidya Ramasamy, Harvey Teo, Victor Samuel Rajadurai, Suresh Chandran
A female preterm infant was born to a non-consanguineous couple at 35 weeks of gestation. On day 8 of life, while on full feeds, she developed prolonged apnoea and bradycardia, requiring respiratory support. Her abdomen was soft with unremarkable serial abdominal X-rays. Her septic screen was negative. Metabolic acidosis was worsening despite treatment. Echocardiography showed evidence of high pulmonary pressures. With further deterioration, an ultrasound scan of the abdomen was requested in view of the rising suspicion of abdominal pathology in the absence of sepsis and metabolic disorders...
September 28, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27440633/cerebrospinal-fluid-volume-in-neonates-undergoing-spinal-anaesthesia-a-descriptive-magnetic-resonance-imaging-study
#4
A Rochette, M-P Malenfant Rancourt, C Sola, O Prodhomme, M Saguintaah, R Schaub, N Molinari, X Capdevila, C Dadure
BACKGROUND: Spinal anaesthesia (SA) reduces the risk of postoperative apnoea after general anaesthesia in neonates. In 30% of patients, however, the duration of anaesthesia provided does not allow completion of surgery. When compared with term infants, formerly preterm neonates experience a shorter duration of anaesthesia after SA. A difference in the cerebrospinal fluid (CSF) volume between those two populations could explain this difference, but this has never been investigated. The study was designed to evaluate the relationship between the spinal CSF volume and patient characteristics in neonates...
August 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27390110/aminophylline-associated-irritable-behaviour-in-preterm-neonates
#5
Tomoki Maeda, Masanori Inoue, Kazuhito Sekiguchi, Kenji Ihara
AIM: This study investigated the effect of aminophylline on behaviour and autonomic function in the preterm period. METHOD: Subjects were preterm infants cared for in the Oita University hospital from August 2012 to October 2014. The group that was administered aminophylline (Am+) and the group that received no aminophylline (Am-) included 11 cases that exhibited a mean gestational age of 28weeks 5days and a mean birth weight of 1109g and 8 cases that exhibited a mean gestational age of 30weeks 5days and a mean birth weight of 1223g, respectively...
August 2016: Early Human Development
https://www.readbyqxmd.com/read/27109425/the-clinical-effectiveness-and-cost-effectiveness-of-heated-humidified-high-flow-nasal-cannula-compared-with-usual-care-for-preterm-infants-systematic-review-and-economic-evaluation
#6
Nigel Fleeman, James Mahon, Vickie Bates, Rumona Dickson, Yenal Dundar, Kerry Dwan, Laura Ellis, Eleanor Kotas, Marty Richardson, Prakesh Shah, Ben Nj Shaw
BACKGROUND: Respiratory problems are one of the most common causes of morbidity in preterm infants and may be treated with several modalities for respiratory support such as nasal continuous positive airway pressure (NCPAP) or nasal intermittent positive-pressure ventilation. The heated humidified high-flow nasal cannula (HHHFNC) is gaining popularity in clinical practice. OBJECTIVES: To address the clinical effectiveness of HHHFNC compared with usual care for preterm infants we systematically reviewed the evidence of HHHFNC with usual care following ventilation (the primary analysis) and with no prior ventilation (the secondary analysis)...
April 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27010019/treatment-options-for-apnoea-of-prematurity
#7
REVIEW
Sarah U Morton, Vincent C Smith
Apnoea of prematurity (AOP) affects almost all infants born at <28 weeks gestation or with birth weight <1000 g. When untreated, AOP may be associated with negative outcomes. Because of these negative outcomes, effective treatment for AOP is an important part of optimising care of preterm infants. Standard treatment usually involves xanthine therapy and respiratory support. Cutting-edge work with stochastic vibrotactile stimulation and new pharmaceutical agents continues to expand therapeutic options...
July 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/26897033/hypoxic-events-and-concomitant-factors-in-preterm-infants-on-non-invasive-ventilation
#8
Omid Sadeghi Fathabadi, Timothy Gale, Kevin Wheeler, Gemma Plottier, Louise S Owen, J C Olivier, Peter A Dargaville
Automated control of inspired oxygen for newborn infants is an emerging technology, currently limited by reliance on a single input signal (oxygen saturation, SpO2). This is while other signals that may herald the onset of hypoxic events or identify spurious hypoxia are not usually utilised. We wished to assess the frequency of apnoea, loss of circuit pressure and/or motion artefact in proximity to hypoxic events in preterm infants on non-invasive ventilation. Hypoxic events (SpO2 < 80 %) were identified using a previously acquired dataset obtained from preterm infants receiving non-invasive ventilation...
February 20, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/26893515/question-2-vaccinating-preterm-infants-in-resource-poor-settings-what-is-the-incidence-of-apnoea-bradycardia-and-need-for-respiratory-support
#9
Andrew James McArdle, Guy Mugisha, Dieudonne Birahinduka
No abstract text is available yet for this article.
March 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/26712299/acute-neonatal-appendicitis-in-a-preterm
#10
Sihem Mammou, Imen Ayadi, Emira Ben Hamida, Zahra Marrakchi
Acute neonatal appendicitis is very rare in the neonatal period. It is usually associated with comorbidity including prematurity. Symptoms are non-specific. The prognosis is marked by high risk of mortality and morbidity. Here, we report a case of preterm new born who presented with sepsis, apnoea, and digestive signs. The laparotomy revealed perforated appendicitis complicated with peritonitis.
October 2015: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/26639118/the-last-and-first-frontier-emerging-challenges-for-hiv-treatment-and-prevention-in-the-first-week-of-life-with-emphasis-on-premature-and-low-birth-weight-infants
#11
Mark F Cotton, Sandi Holgate, Aurelie Nelson, Helena Rabie, Catherine Wedderburn, Mark Mirochnick
INTRODUCTION: There is new emphasis on identifying and treating HIV in the first days of life and also an appreciation that low birth weight (LBW) and preterm delivery (PTD) frequently accompany HIV-related pregnancy. Even in the absence of HIV, PTD and LBW contribute substantially to neonatal and infant mortality. HIV-exposed and -infected infants with these characteristics have received little attention thus far. As HIV programs expand to meet the 90-90-90 target for ending the HIV pandemic, attention should focus on newborn infants, including those delivered preterm or of LBW...
2015: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/26497835/inhibitory-respiratory-responses-to-progesterone-and-allopregnanolone-in-newborn-rats-chronically-treated-with-caffeine
#12
NagaPraveena Uppari, Vincent Joseph, Aida Bairam
KEY POINTS: In premature newborns, recurrent apnoea is systematically treated with caffeine to prevent long-term neurocognitive disorders, but a substantial percentage of apnoea persists particularly in neonates born before 28 weeks of gestation. Progesterone has been proposed as a respiratory stimulant potentially suitable for the treatment of newborn apnoea persistent to caffeine. Accordingly we asked whether acute progesterone administration reduces apnoea frequency in newborn rats treated with caffeine...
January 15, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/26141572/continuous-distending-pressure-for-respiratory-distress-in-preterm-infants
#13
REVIEW
Jacqueline J Ho, Prema Subramaniam, Peter G Davis
BACKGROUND: Respiratory distress syndrome (RDS) is the single most important cause of morbidity and mortality in preterm infants. In infants with progressive respiratory insufficiency, intermittent positive pressure ventilation (IPPV) with surfactant is the standard treatment for the condition, but it is invasive, potentially resulting in airway and lung injury. Continuous distending pressure (CDP) has been used for the prevention and treatment of RDS, as well as for the prevention of apnoea, and in weaning from IPPV...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26109120/a-multicentre-randomised-controlled-non-inferiority-trial-comparing-high-flow-therapy-with-nasal-continuous-positive-airway-pressure-as-primary-support-for-preterm-infants-with-respiratory-distress-the-hipster-trial-study-protocol
#14
RANDOMIZED CONTROLLED TRIAL
Calum T Roberts, Louise S Owen, Brett J Manley, Susan M Donath, Peter G Davis
INTRODUCTION: High flow (HF) therapy is an increasingly popular mode of non-invasive respiratory support for preterm infants. While there is now evidence to support the use of HF to reduce extubation failure, there have been no appropriately designed and powered studies to assess the use of HF as primary respiratory support soon after birth. Our hypothesis is that HF is non-inferior to the standard treatment--nasal continuous positive airway pressure (NCPAP)--as primary respiratory support for preterm infants...
2015: BMJ Open
https://www.readbyqxmd.com/read/26099229/the-whole-spectrum-of-cystic-periventricular-leukomalacia-of-the-preterm-infant-results-from-a-large-consecutive-case-series
#15
Bernhard Resch, Elisabeth Resch, Ute Maurer-Fellbaum, Elisabeth Pichler-Stachl, Michael Riccabona, Nora Hofer, Berndt Urlesberger
PURPOSE: The purpose of this study is to describe features of cystic periventricular leukomalacia (PVL) in a large consecutive cohort study including long-term neurodevelopmental follow-up. METHODS: We performed a retrospective single-centre cohort study including all preterm infants ≤35 weeks of gestational age with PVL diagnosed by ultrasound scans (US) from a tertiary care university hospital between 1988 and 2012. RESULTS: The majority of 160 consecutively diagnosed cases had a gestational age between 28 and 32 weeks (60...
September 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/26058963/regional-spinal-epidural-caudal-versus-general-anaesthesia-in-preterm-infants-undergoing-inguinal-herniorrhaphy-in-early-infancy
#16
REVIEW
Lisa J Jones, Paul D Craven, Anil Lakkundi, Jann P Foster, Nadia Badawi
BACKGROUND: With improvements in neonatal intensive care, more preterm infants are surviving the neonatal period and presenting for surgery in early infancy. Inguinal hernia is the most common condition requiring early surgery, appearing in 38% of infants whose birth weight is between 751 grams and 1000 grams. Approximately 20% to 30% of otherwise healthy preterm infants having general anaesthesia for inguinal hernia surgery at a postmature age have at least one apnoeic episode within the postoperative period...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25633155/sound-reduction-management-in-the-neonatal-intensive-care-unit-for-preterm-or-very-low-birth-weight-infants
#17
REVIEW
Abdulraoof Almadhoob, Arne Ohlsson
BACKGROUND: Infants in the neonatal intensive care unit (NICU) are subjected to stress, including sound of high intensity. The sound environment in the NICU is louder than most home or office environments and contains disturbing noises of short duration and at irregular intervals. There are competing auditory signals that frequently challenge preterm infants, staff and parents. The sound levels in NICUs often exceed the maximum acceptable level of 45 decibels (dB), recommended by the American Academy of Pediatrics...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25545416/live-music-reduces-stress-levels-in-very-low-birthweight-infants
#18
Diana Schwilling, Michael Vogeser, Fabian Kirchhoff, Frauke Schwaiblmair, Anne-Laure Boulesteix, Andreas Schulze, Andreas W Flemmer
AIM: Music might benefit preterm infants in stressful, intensive care environments. However, data on stress level indicators, determined by salivary cortisol levels, are scarce. We evaluated the effect of live harp music on the stress level indicators of preterm infants in a neonatal intensive care unit (NICU). METHODS: We exposed 20 stable preterm infants to music for 15 min on three consecutive days. Saliva was collected before the music was played and 25 min and 4 h after it ended...
April 2015: Acta Paediatrica
https://www.readbyqxmd.com/read/25382905/safety-and-effectiveness-of-bubble-continuous-positive-airway-pressure-in-preterm-neonates-with-respiratory-distress
#19
S S Mathai, A Rajeev, K M Adhikari
BACKGROUND: Studies on Bubble Continuous Positive Airway Pressure (B-CPAP) as respiratory support for neonates are few. The aim of our study was to determine the efficacy and safety of B-CPAP in preterm neonates requiring respiratory support. METHODS: A prospective observation study was done on 50 preterm babies requiring respiratory support for mild to moderate respiratory distress. Support was given with short, nasal cannulae. Surfactant was administered when indicated...
October 2014: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/25318667/is-synchronised-nippv-more-effective-than-nippv-and-ncpap-in-treating-apnoea-of-prematurity-aop-a-randomised-cross-over-trial
#20
RANDOMIZED CONTROLLED TRIAL
Camilla Gizzi, Francesco Montecchia, Valentina Panetta, Chiara Castellano, Chiara Mariani, Maristella Campelli, Paola Papoff, Corrado Moretti, Rocco Agostino
BACKGROUND: Apnoea, desaturations and bradycardias are common problems in preterm infants which can be treated with nasal continuous positive airway pressure (NCPAP) and nasal intermittent positive pressure ventilation (NIPPV). It is unclear whether synchronised NIPPV (SNIPPV) would be even more effective. OBJECTIVE: To assess the effects of flow-SNIPPV, NIPPV and NCPAP on the rate of desaturations and bradycardias in preterm infants and, secondarily, to evaluate their influence on pattern of breathing and gas exchange...
January 2015: Archives of Disease in Childhood. Fetal and Neonatal Edition
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