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Asymptomatic carotid atherosclerosis

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https://www.readbyqxmd.com/read/29671694/risk-allele-of-gene-variant-rs6584389-is-associated-with-increased-intima-media-thickness-in-patients-with-type-2-diabetes
#1
Miriam Kozarova, Zuzana Malachovska, Jozef Zidzik, Martin Javorsky, Katarina Demkova, Viera Habalova, Ivan Tkac
BACKGROUND: Genome-wide association studies identified several gene variants associated with peripheral arterial disease (PAD). Among them, rs6584389 A>C was significantly associated with PAD defined by decreased ankle-brachial index (ABI). The aim of this study was to investigate whether the rs6584389 variant is also associated with the earlier stages of atherosclerosis assessed by intima-media thickness (IMT) or pulse-wave velocity (PWV) in clinically asymptomatic subjects with type 2 diabetes (T2DM), a group of patients with a high cardiovascular risk...
April 19, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29611041/time-of-exposure-to-night-work-and-carotid-atherosclerosis-a-structural-equation-modeling-approach-using-baseline-data-from-elsa-brasil
#2
Aline Silva-Costa, Joanna Guimarães, Dora Chor, Maria de Jesus Mendes da Fonseca, Isabela Bensenor, Itamar Santos, Sandhi Barreto, Rosane Härter Griep
PURPOSE: The study of cardiovascular diseases (CVD) associated with night work is difficult due to the long period required for conditions to manifest and the healthy-worker effect. Analyzing asymptomatic pre-clinical changes in the atherosclerotic process is a way to assess the pathways between exposure to night work and CVD. AIM: To evaluate the associations between night work and subclinical atherosclerosis measured by carotid intima-media thickness (CIMT) using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)...
April 2, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29604092/prognostic-relevance-of-subclinical-coronary-and-carotid-atherosclerosis-in-a-diabetic-and-non-diabetic-asymptomatic-population
#3
Andrea Igoren Guaricci, Valentina Lorenzoni, Marco Guglielmo, Saima Mushtaq, Giuseppe Muscogiuri, Filippo Cademartiri, Mark Rabbat, Daniele Andreini, Gaetano Serviddio, Nicola Gaibazzi, Mauro Pepi, Gianluca Pontone
BACKGROUD: The aim of the study was to evaluate the incremental prognostic benefit of carotid artery disease and subclinical coronary artery disease (CAD) features in addition to clinical evaluation in a asymptomatic population. METHODS: Over a six-year period, 10-year-FRS together with carotid ultrasound (CUS) and coronary computed tomography angiography (CCTA) were evaluated for the prediction of major adverse cardiac events (MACE). RESULTS: We enrolled 517 consecutive asymptomatic patients (63% male, 64±10 years of age, 17...
March 31, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29571589/impact-of-weight-loss-on-epicardial-fat-and-carotid-intima-media-thickness-after-laparoscopic-sleeve-gastrectomy-a-prospective-study
#4
C Altin, V Erol, E Aydin, M Yilmaz, M A Tekindal, L E Sade, H Gulay, H Muderrisoglu
BACKGROUND AND AIMS: Cardiovascular disease (CVD) is one of the leading causes of mortality in obese patients. We aimed to investigate the influence of significant weight loss following laparoscopic sleeve gastrectomy (LSG) on carotid intima media thickness (CIMT) and epicardial fat thickness (EFT) which are the independent predictors of subclinical atherosclerosis. METHODS AND RESULTS: Patients were recruited for standard indications. A total of 105 patients (79 women and 26 men) with the mean age of 43...
February 9, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29562638/characterization-of-carotid-smooth-muscle-cells-during-phenotypic-transition
#5
Haize Goikuria, Maria Del Mar Freijo, Reyes Vega Manrique, María Sastre, Elena Elizagaray, Ana Lorenzo, Koen Vandenbroeck, Iraide Alloza
Vascular smooth muscle cells (VSMCs) are central players in carotid atherosclerosis plaque development. Although the precise mechanisms involved in plaque destabilization are not completely understood, it is known that VSMC proliferation and migration participate in plaque stabilization. In this study, we analyzed expression patterns of genes involved in carotid atherosclerosis development (e.g., transcription factors of regulation of SMC genes) of VSMCs located inside or outside the plaque lesion that may give clues about changes in phenotypic plasticity during atherosclerosis...
March 18, 2018: Cells
https://www.readbyqxmd.com/read/29555791/association-of-prehypertension-and-hyperhomocysteinemia-with-subclinical-atherosclerosis-in-asymptomatic-chinese-a-cross-sectional-study
#6
Bo Liu, Zhihao Chen, Xiaoqi Dong, Guangming Qin
OBJECTIVES: Comorbid hypertension and hyperhomocysteinemia is an important risk factor for carotid atherosclerotic plaque formation. We put forward the hypothesis that the subjects with comorbid prehypertension and hyperhomocysteinemia also had an increased risk of subclinical atherosclerosis, using carotid intima-media thickness (CIMT) as the marker of the atherosclerotic process. METHODS: A total of 4102 asymptomatic Chinese subjects aged 18-60 years were divided into four groups according to blood pressure (BP) and homocysteine (HCY) level: the control group without prehypertension or hyperhomocysteinemia, isolated prehypertension group, simple hyperhomocysteinemia group and prehypertension with hyperhomocysteinemia group...
March 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29482876/low-carotid-stump-pressure-as-a-predictor-for-ischemic-symptoms-and-as-a-marker-for-compromised-cerebral-reserve-in-octogenarians-undergoing-carotid-endarterectomy
#7
Sam C Tyagi, Matthew J Dougherty, Shinichi Fukuhara, Douglas A Troutman, Danielle M Pineda, Hong Zheng, Keith D Calligaro
BACKGROUND: Carotid artery occlusive disease can cause stroke by embolization, thrombosis, and hypoperfusion. The majority of strokes secondary to cervical carotid atherosclerosis are believed to be of embolic etiology. However, cerebral hypoperfusion could be an important factor in perioperative stroke. We retrospectively reviewed the stump pressure (SP) of carotid endarterectomy (CEA) of patients at Pennsylvania Hospital to identify whether physiologic perfusion differences account for differences in perioperative stroke rates, particularly in octogenarians...
February 23, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29479382/early-diagnosis-and-treatment-of-coronary-heart-disease-in-asymptomatic-subjects-with-advanced-vascular-atherosclerosis-of-the-carotid-artery-type-iii-and-iv-b-findings-using-ultrasound-and-risk-factors
#8
Ansgar Adams, Waldemar Bojara, Klaus Schunk
Background: A study was conducted as to whether the early diagnosis of coronary heart disease in asymptomatic subjects with advanced atherosclerosis of the carotid artery which additionally shows at least one risk factor is successful using ultrasound technology. Methods: Within the scope of an occupational screening program using subjects from diverse employment sectors, people were given the opportunity to determine their risk of heart attack. During the study the total plaque area (TPA), the maximum plaque thickness in the carotid artery and the PROCAM-Scores of 3,748 healthy men and 2,260 healthy women between the ages of 20 and 64 years were determined...
February 2018: Cardiology Research
https://www.readbyqxmd.com/read/29473126/an-efficient-data-mining-framework-for-the-characterization-of-symptomatic-and-asymptomatic-carotid-plaque-using-bidimensional-empirical-mode-decomposition-technique
#9
Filippo Molinari, U Raghavendra, Anjan Gudigar, Kristen M Meiburger, U Rajendra Acharya
Atherosclerosis is a type of cardiovascular disease which may cause stroke. It is due to the deposition of fatty plaque in the artery walls resulting in the reduction of elasticity gradually and hence restricting the blood flow to the heart. Hence, an early prediction of carotid plaque deposition is important, as it can save lives. This paper proposes a novel data mining framework for the assessment of atherosclerosis in its early stage using ultrasound images. In this work, we are using 1353 symptomatic and 420 asymptomatic carotid plaque ultrasound images...
February 23, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29461604/a-novel-ultrasound-based-vascular-calcification-score-calcs-to-detect-subclinical-atherosclerosis
#10
R Flore, M A Zocco, M E Ainora, C Fonnesu, A Nesci, A Gasbarrini, F R Ponziani
OBJECTIVE: To quantify non-coronary vascular calcifications (VC) in asymptomatic patients at low-intermediate cardiovascular risk by a new color Doppler ultrasound (DUS)-based score (the carotid, aortic, lower limbs calcium score, CALCs), and to correlate this score with classical parameters associated with cardiovascular risk [carotid intima media thickness (IMT), and arterial stiffness (AS)]. PATIENTS AND METHODS: All consecutive asymptomatic patients who underwent a screening DUS of non-coronary circulation were evaluated and patients at low-intermediate cardiovascular risk were selected according to Framingham risk score (FRS)...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29432486/fractal-analysis-of-plaque-border-a-novel-method-for-the-quantification-of-atherosclerotic-plaque-contour-irregularity-is-associated-with-pro-atherogenic-plasma-lipid-profile-in-subjects-with-non-obstructive-carotid-stenoses
#11
Francesco Moroni, Marco Magnoni, Vittoria Vergani, Enrico Ammirati, Paolo G Camici
BACKGROUND AND AIMS: Plaque border irregularity is a known imaging characteristic of vulnerable plaques, but its evaluation heavily relies on subjective evaluation and operator expertise. Aim of the present work is to propose a novel fractal-analysis based method for the quantification of atherosclerotic plaque border irregularity and assess its relation with cardiovascular risk factors. METHODS AND RESULTS: Forty-two asymptomatic subjects with carotid stenosis underwent ultrasound evaluation and assessment of cardiovascular risk factors...
2018: PloS One
https://www.readbyqxmd.com/read/29425278/carotid-intima-media-thickness-and-silent-brain-infarctions-in-a-biracial-cohort-the-atherosclerosis-risk-in-communities-aric-study
#12
Melissa C Caughey, Ye Qiao, B Gwen Windham, Rebecca F Gottesman, Thomas H Mosley, Bruce A Wasserman
Background: Both hypertensive and atherosclerotic processes contribute to common carotid artery intima-media thickness (CCA-IMT). Elevated CCA-IMT may be indicative of subclinical cerebrovascular disease; however, its role in the absence of concomitant carotid artery plaque is uncertain, and few studies have examined associations in black populations. Materials and Methods: At cohort visit 3 (1993-1995) a subset of stroke-free participants (641 blacks and 702 whites, mean age 63) from the Atherosclerosis Risk in Communities (ARIC) study was imaged by brain MRI and carotid ultrasound...
February 7, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29424477/association-of-lipoprotein-associated-phospholipase-a2-mass-with-asymptomatic-cerebral-artery-stenosis
#13
Youxin Wang, Bin Zhou, Pingan Zhou, Yan Yao, Qinghua Cui, Yingping Liu, Jichun Yang, Shouling Wu, Xingquan Zhao, Yong Zhou
Cerebral artery stenosis (CAS) is the most important causes of ischaemic stroke. Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays 2 diverse roles in atherosclerosis (pro-inflammatory and anti-inflammatory), and the association between Lp-PLA2 mass and cardiovascular or cerebrovascular events is inconsistent among previous studies. A cross-sectional study including 2012 North Chinese adults aged ≥40 years was performed in 2010-2011 to investigate whether Lp-PLA2 mass is associated with asymptomatic cerebral artery stenosis (ACAS)...
February 9, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29412115/genetic-variations-and-subclinical-markers-of-carotid-atherosclerosis-in-patients-with-type-2-diabetes-mellitus
#14
Sara Mankoc Ramus, Danijel Petrovic
Atherosclerosis and its cardiovascular complications are the main cause of death in diabetic patients. Patients with diabetes mellitus have a greater than 10-fold risk of cardiovascular disease in their lifetime. The carotid intima-media thickness (cIMT), a surrogate marker for the presence and progression of atherosclerosis, predicts future cardiovascular events in asymptomatic subjects with type 2 diabetes mellitus (T2DM). This review focuses on genetic variants that contribute to the pathobiology of subclinical atherosclerosis in the setting of T2DM...
February 5, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29402147/carotid-im-gsm-is-better-than-imt-for-identifying-patients-with-multiple-arterial-disease
#15
Fisnik Jashari, Pranvera Ibrahimi, Elias Johansson, Christer Grönlund, Per Wester, Michael Y Henein
OBJECTIVE: Atherosclerosis is a systemic inflammatory disease that can affect more than one arterial bed simultaneously. The aim of this study was to determine the relationship between ultrasound markers of atherosclerosis and multiple arterial disease. DESIGN: We have included 87 currently asymptomatic carotid disease patients (mean age 69 ± 6 year, 34% females) in this study. Intima media thickness (IMT) and intima media-grey scale median (IM-GSM) were measured in the common carotid artery (CCA), and correlated with previous and/or current atherosclerotic vascular disease in the coronary, carotid and lower extremities...
February 6, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29366153/characteristics-of-carotid-atherosclerosis-and-brain-white-matter-hyperintensities-in-asymptomatic-patients-with-intermediate-stenosis
#16
Francesco Moroni, Enrico Ammirati, Marco Magnoni, Maria Assunta Rocca, Roberta Messina, Nicoletta Anzalone, Costantino De Filippis, Isabella Scotti, Francesca Besana, Pietro Spagnolo, Ornella Rimoldi, Roberto Chiesa, Andrea Falini, Massimo Filippi, Paolo Guido Camici
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29358636/association-between-h-type-hypertension-and-asymptomatic-extracranial-artery-stenosis
#17
Jia Zhang, Yanfang Liu, Anxin Wang, Dandan Wang, Ruixuan Jiang, Jiaokun Jia, Shengyun Chen, Xingquan Zhao
Asymptomatic extracranial artery stenosis (ECAS) is a well-known risk factor for stroke and H-type hypertension, which is defined as hypertension with hyperhomocysteinemia, is associated with cardio-cerebrovascular diseases. However, the impact of H-type hypertension on ECAS is mostly unknown. We designed this study to investigate the association between H-type hypertension and prevalence of ECAS. We included 2330 participants in this study and classified them into four groups: the control group without hypertension or hyperhomocysteinemia, isolated hypertension group, isolated hyperhomocysteinemia group and H-type hypertension group...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317141/serum-levels-of-osteopontin-predict-major-adverse-cardiovascular-events-in-patients-with-severe-carotid-artery-stenosis
#18
Federico Carbone, Fabio Rigamonti, Fabienne Burger, Aline Roth, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Aldo Pende, Aldo Bonaventura, Luca Liberale, Alessandra Vecchié, Franco Dallegri, François Mach, Fabrizio Montecucco
BACKGROUND: Inflammatory mediators in the blood stream and within plaques are key determinants in atherogenesis. Here, we investigated serum osteopontin (OPN) as a potential predictor of poor outcome in patients with severe carotid atherosclerosis. METHODS: Carotid plaques and serum were collected from patients asymptomatic (n=185) or symptomatic (n=40) for ischemic stroke. Plaques were stained for lipids, smooth muscle cells, neutrophils, M1 and M2 macrophage subsets and matrix metallopropteinase-9 (MMP-9)...
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29279888/prevalence-of-systemic-atherosclerosis-burdens-and-overlapping-stroke-etiologies-and-their-associations-with-long-term-vascular-prognosis-in-stroke-with-intracranial-atherosclerotic-disease
#19
Takao Hoshino, Leila Sissani, Julien Labreuche, Gregory Ducrocq, Philippa C Lavallée, Elena Meseguer, Céline Guidoux, Lucie Cabrejo, Cristina Hobeanu, Fernando Gongora-Rivera, Pierre-Jean Touboul, Philippe Gabriel Steg, Pierre Amarenco
Importance: Patients who have experienced stroke with intracranial atherosclerotic disease (ICAD) may also have concomitant atherosclerosis in different arterial beds and other possible causes for ischemic stroke. However, little is known about the frequency and prognostic effect of such overlapping diseases. Objectives: To describe the prevalence of systemic atherosclerotic burdens and overlapping stroke etiologies and their contributions to long-term prognoses among patients who have experienced stroke with ICAD...
February 1, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29239051/coronary-and-carotid-atherosclerosis-in-asymptomatic-male-marathon-runners
#20
C Burgstahler, H Cipowicz, C Thomas, C Schabel, S Mangold, D Ketelsen, C D Claussen, A M Niess, I Tsiflikas
The aim of the study was to evaluate the diagnostic accuracy of carotid ultrasound (CU) to predict coronary atherosclerosis in asymptomatic male marathon runners. A total of 49 male marathon runners older than 45 years (mean age 53.3 ± 7.2 years, range 45-74 years) received CU and cardiac CT angiography (CTA) including calcium scoring (CS). Results of CU and CTA were classified binary: 1. Absence of atherosclerosis and 2. Presence of atherosclerosis. The extent of atherosclerosis was not primary end point of the study...
April 2018: Scandinavian Journal of Medicine & Science in Sports
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