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Asymptomatic carotid atherosclerosis

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https://www.readbyqxmd.com/read/28623250/adamts-7-is-associated-with-a-high-risk-plaque-phenotype-in-human-atherosclerosis
#1
Eva Bengtsson, Karin Hultman, Pontus Dunér, Giuseppe Asciutto, Peter Almgren, Marju Orho-Melander, Olle Melander, Jan Nilsson, Anna Hultgårdh-Nilsson, Isabel Gonçalves
Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease. Experimental studies have provided evidence for a functional role of ADAMTS-7 in both injury-induced vascular neointima formation and development of atherosclerotic lesions. However, whether ADAMTS-7 is associated with a specific plaque phenotype in humans has not been investigated...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28615715/rnaseq-based-transcriptomics-study-of-smcs-from-carotid-atherosclerotic-plaque-bmp2-and-ids-proteins-are-crucial-regulators-of-plaque-stability
#2
Iraide Alloza, Haize Goikuria, Juan Luis Idro, Juan Carlos Triviño, José María Fernández Velasco, Elena Elizagaray, María García-Barcina, Genoveva Montoya-Murillo, Esther Sarasola, Reyes Vega Manrique, Maria Del Mar Freijo, Koen Vandenbroeck
Carotid artery atherosclerosis is a risk factor to develop cerebrovascular disease. Atheroma plaque can become instable and provoke a cerebrovascular event or else remain stable as asymptomatic type. The exact mechanism involved in plaque destabilization is not known but includes among other events smooth muscle cell (SMC) differentiation. The goal of this study was to perform thorough analysis of gene expression differences in SMCs isolated from carotid symptomatic versus asymptomatic plaques. Comparative transcriptomics analysis of SMCs based on RNAseq technology identified 67 significant differentially expressed genes and 143 significant differentially expressed isoforms in symptomatic SMCs compared with asymptomatic...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28610589/high-sensitivity-cardiac-troponin-t-is-a-biomarker-for-atherosclerosis-in-systemic-lupus-erythematous-patients-a-cross-sectional-controlled-study
#3
Gillian Divard, Rachid Abbas, Camille Chenevier-Gobeaux, Noémie Chanson, Brigitte Escoubet, Marie-Paule Chauveheid, Antoine Dossier, Thomas Papo, Monique Dehoux, Karim Sacre
BACKGROUND: Cardiovascular disease (CVD) is the main cause of death in systemic lupus erythematous (SLE) patients. The Framingham score underestimates the risk for CVD in this population. Our study aimed to determine whether serum high-sensitivity cardiac troponin T (HS-cTnT) might help to identify SLE patients at risk for CVD. METHODS: The presence of carotid plaques was prospectively assessed by ultrasound in 63 consecutive SLE patients asymptomatic for CVD and 18 controls...
June 13, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28577790/impact-of-provider-characteristics-on-outcomes-of-carotid-endarterectomy-for-asymptomatic-carotid-stenosis-in-new-york-state
#4
Andrew J Meltzer, Christopher Agrusa, Peter H Connolly, Darren B Schneider, Art Sedrakyan
OBJECTIVE: (s)The purpose of this study was to explore the impact of surgeon characteristics (including annual volume, specialty, and years in practice) on outcomes of carotid endarterectomy (CEA) for asymptomatic carotid atherosclerosis in New York State. METHODS: The New York Statewide Planning and Cooperation System (SPARCS) database was utilized to identify patients undergoing CEA from 2004-2011. Provider characteristics were determined by linkage to the New York Office of Professions and National Provider Identification databases...
May 31, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28576484/signs-of-subclinical-atherosclerosis-in-asymptomatic-patients-at-increased-risk-of-type-2-diabetes-mellitus
#5
Loretta Zsuzsa Kiss, Zsolt Bagyura, Réka Vadas, Lívia Polgár, Árpád Lux, Eszter Édes, Orsolya Szenczi, Pál Soós, Zsolt Szelid, Dávid Becker, György Jermendy, Béla Merkely
AIMS: We aimed to study carotid intima media thickness (CIMT) in asymptomatic patients with an increased risk of type 2 diabetes mellitus (T2DM) and in a pre-diabetic state. METHODS: Diabetes risk assessment was performed in 2420 participants in a voluntary screening program between 2011 and 2013. The risk of T2DM was estimated by the Findrisc scoring system (FR). A FR≥12 was considered as increased risk. HbA1c% between 5.7 and 6.4% signified a pre-diabetic state...
May 25, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28575478/the-preservation-of-cognition-1-yr-after-carotid-endarterectomy-in-patients-with-prior-cognitive-decline
#6
Robert J Dempsey, Daren C Jackson, Stephanie M Wilbrand, Carol C Mitchell, Sara E Berman, Sterling C Johnson, Nirvedh H Meshram, Tomy Varghese, Bruce P Hermann
BACKGROUND: Vascular cognitive decline is critically important in the course of atherosclerosis and stroke. OBJECTIVE: To explore the hypothesis that carotid endarterectomy (CEA) by removing an unstable plaque may slow the course of vascular cognitive decline in both symptomatic and asymptomatic patients. METHODS: Patients with clinically significant (>60%) carotid stenosis were studied preop and 1 yr post-CEA for clinical symptoms, vascular cognitive decline, instability of carotid plaque-presence of microemboli, brain white matter changes, and medical risk factors...
June 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28543093/relationship-between-carotid-atherosclerosis-and-coronary-artery-calcification-in-asymptomatic-diabetic-patients-a-prospective-multicenter-study
#7
Anand Jeevarethinam, Shreenidhi Venuraju, Alain Dumo, Sherezade Ruano, Vishal S Mehta, Miranda Rosenthal, Devaki Nair, Mark Cohen, Daniel Darko, Avijit Lahiri, Roby Rakhit
BACKGROUND: The value of screening sub-clinical atherosclerosis in asymptomatic patients with type 2 diabetes mellitus (T2DM) remains controversial. HYPOTHESIS: An integrated model incorporating carotid intima-media thickness (CIMT) and carotid plaque with traditional risk factors can be used to predict prevalence and severity of coronary artery calcification in asymptomatic T2DM patients. METHODS: A cohort of 262 asymptomatic T2DM patients were prospectively studied with carotid ultrasound to evaluate CIMT and carotid plaque and also a computed tomography coronary artery calcium (CT-CAC) scan...
May 25, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28539213/medical-management-of-asymptomatic-carotid-artery-stenosis
#8
REVIEW
Aaron W Aday, Joshua A Beckman
Carotid artery atherosclerosis is a major risk factor for both stroke and cardiovascular disease. Appropriate management of asymptomatic patients with carotid artery stenosis (CAS) remains unclear. Although several randomized clinical trials support revascularization in asymptomatic patients with severe CAS to reduce stroke risk, the participants in these trials did not receive optimal medical therapy (OMT) by today's standards. For many individuals, medical therapy may provide excellent risk reduction without the periprocedural risk of endarterectomy or stenting...
May 21, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28537783/association-of-mild-to-moderate-reduction-in-glomerular-filtration-rate-with-subclinical-atherosclerosis-in-postmenopausal-women
#9
Florina Parv, Andrei Beceanu, Rodica Avram, Romulus Zorin Timar, Bogdan Timar, Florica Gadalean
BACKGROUND: Due to loss of hormonal protective effects, postmenopausal women have an increased cardiovascular (CV) risk. Chronic kidney disease (CKD) is a well-established risk factor for CV disease, but little is known whether mild-to-moderate kidney dysfunction is associated with atherosclerosis burden in the postmenopausal asymptomatic women. MATERIALS AND METHODS: Subclinical atherosclerosis was evaluated in 125 postmenopausal women with no clinical form of atherosclerosis, by carotid and femoral ultrasonography, ankle-brachial index (ABI), and flow-mediated dilation (FMD)...
May 24, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28441695/increased-high-risk-coronary-plaque-burden-is-associated-with-arterial-stiffness-in-patients-with-type-2-diabetes-without-clinical-signs-of-coronary-artery-disease-a-computed-tomography-angiography-study
#10
Kristian L Funck, Esben Laugesen, Kristian Øvrehus, Jesper M Jensen, Bjarne L Nørgaard, Damini Dey, Troels K Hansen, Per L Poulsen
OBJECTIVES: Arterial stiffness and subclinical coronary atherosclerosis may yield valuable information on cardiovascular risk. We aimed to characterize coronary atherosclerosis in asymptomatic patients with type 2 diabetes and healthy controls and to investigate the association between baseline arterial stiffness and coronary plaque volumes after 5-year follow-up. METHODS: Data from 45 patients and 61 matched controls were available for coronary plaque assessment...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28377040/subclinical-cardiovascular-disease-assessment-and-its-relationship-with-cardiovascular-risk-score-in-a-healthy-adult-population-a-cross-sectional-community-based-study
#11
Ovidiu Mitu, Mihai Roca, Mariana Floria, Antoniu Octavian Petris, Mariana Graur, Florin Mitu
INTRODUCTION: The aim of this study is to evaluate the relationship and the accuracy of SCORE (Systematic Coronary Risk Evaluation Project) risk correlated to multiple methods for determining subclinical cardiovascular disease (CVD) in a healthy population. MATERIAL AND METHODS: This cross-sectional study included 120 completely asymptomatic subjects, with an age range 35-75 years, and randomly selected from the general population. The individuals were evaluated clinically and biochemical, and the SCORE risk was computed...
April 1, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/28367862/asymptomatic-plaques-of-lower-peripheral-arteries-and-their-association-with-cardiovascular-disease-an-autopsy-study
#12
Eriko Nakamura, Yuichiro Sato, Takashi Iwakiri, Atsushi Yamashita, Sayaka Moriguchi-Goto, Kazunari Maekawa, Toshihiro Gi, Yujiro Asada
AIM: Patients with peripheral artery disease (PAD) have a high prevalence of cardiovascular morbidity and mortality; however, majority of patients with PAD are asymptomatic. This study aimed to histologically evaluate whether asymptomatic, lower extremity artery plaques are associated with systemic atherosclerosis and the onset of cardiovascular disease (CVD) events using autopsy cases. METHODS: We histologically investigated the atherosclerotic plaques of the common iliac, common carotid, coronary, and renal arteries from 121 autopsy cases without symptoms of PAD (mean age:67...
March 31, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28319050/extracellular-matrix-proteomics-identifies-molecular-signature-of-symptomatic-carotid-plaques
#13
Sarah R Langley, Karin Willeit, Athanasios Didangelos, Ljubica Perisic Matic, Philipp Skroblin, Javier Barallobre-Barreiro, Mariette Lengquist, Gregor Rungger, Alexander Kapustin, Ludmilla Kedenko, Chris Molenaar, Ruifang Lu, Temo Barwari, Gonca Suna, Xiaoke Yin, Bernhard Iglseder, Bernhard Paulweber, Peter Willeit, Joseph Shalhoub, Gerard Pasterkamp, Alun H Davies, Claudia Monaco, Ulf Hedin, Catherine M Shanahan, Johann Willeit, Stefan Kiechl, Manuel Mayr
BACKGROUND: The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset of symptoms. METHODS: We performed a proteomics comparison of the vascular extracellular matrix and associated molecules in human carotid endarterectomy specimens from 6 symptomatic versus 6 asymptomatic patients to identify a protein signature for high-risk atherosclerotic plaques...
April 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28296733/clinical-usefulness-of-metabolic-risk-factors-to-identify-young-asymptomatic-women-adults-with-subclinical-atherosclerosis-a-cross-sectional-study
#14
Guangming Qin, Zhihao Chen, Weiwei Su, Xiaoge Geng, Xiaojun Chen, Xiang Xu, Wensheng Pan
Interventions of cardiovascular disease should be implemented in early ages. But most studies were performed in middle aged or elderly adults because of the low prevalence in young, especially for women. We investigate the association between metabolic risk factors and subclinical atherosclerosis in young asymptomatic women adults, using carotid intima-media thickness (CIMT) as a marker of the atherosclerotic process.We performed a cross-sectional study of 950 Chinese young asymptomatic women adults (37.28 ± 5...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28292859/-18-f-fluoride-and-18-f-fluorodeoxyglucose-positron-emission-tomography-after-transient-ischemic-attack-or-minor-ischemic-stroke-case-control-study
#15
COMPARATIVE STUDY
Alex T Vesey, William S A Jenkins, Agnese Irkle, Alastair Moss, Greg Sng, Rachael O Forsythe, Tim Clark, Gemma Roberts, Alison Fletcher, Christophe Lucatelli, James H F Rudd, Anthony P Davenport, Nicholas L Mills, Rustam Al-Shahi Salman, Martin Dennis, William N Whiteley, Edwin J R van Beek, Marc R Dweck, David E Newby
BACKGROUND: Combined positron emission tomography (PET) and computed tomography (CT) can assess both anatomy and biology of carotid atherosclerosis. We sought to assess whether (18)F-fluoride or (18)F-fluorodeoxyglucose can identify culprit and high-risk carotid plaque. METHODS AND RESULTS: We performed (18)F-fluoride and (18)F-fluorodeoxyglucose PET/CT in 26 patients after recent transient ischemic attack or minor ischemic stroke: 18 patients with culprit carotid stenosis awaiting carotid endarterectomy and 8 controls without culprit carotid atheroma...
March 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28290390/prevalence-and-risk-factors-of-asymptomatic-carotid-artery-stenosis-in-indian-population-an-8-year-follow-up-study
#16
Subhash Kaul, Suvarna Alladi, K Rukmini Mridula, V C S Srinivasarao Bandaru, Matapathi Umamashesh, Darapureddy Anjanikumar, Palli Lalitha, R Chandrasekhar
BACKGROUND: Asymptomatic carotid artery stenosis (ACAS) is a marker for cerebrovascular disease, coronary atherosclerosis, and death. AIM: To investigate the prevalence of ACAS in the Indian population, and to correlate ACAS with other vascular risk factors. MATERIALS AND METHODS: We prospectively recruited 1500 individuals who were older than 40 years and asymptomatic for cerebrovascular disease between June 2003 and December 2014. Evaluation of vascular risk factors was done for all the participants...
March 2017: Neurology India
https://www.readbyqxmd.com/read/28251578/accumulation-of-depressive-symptoms-and-carotid-intima-media-thickness-the-cardiovascular-risk-in-young-finns-study
#17
Liisa Keltikangas-Järvinen, Kateryna Savelieva, Kim Josefsson, Marko Elovainio, Laura Pulkki-Råback, Markus Juonala, Olli T Raitakari, Mirka Hintsanen
BACKGROUND: The association between depressive symptoms and subclinical atherosclerosis has been inconsistent. PURPOSE: We sought to replicate our previous study, which demonstrated a positive relation between depressive symptoms and subclinical atherosclerosis assessed with carotid intima-media thickness (IMT) in men, using a newer measurement of carotid IMT and a cumulative loading of depressive symptoms over three follow-ups. METHODS: The sample comprised 996 adults (352 men) aged 30 to 45 years in 2007 from a prospective population-based Finnish sample...
March 1, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28237990/low-serum-levels-of-vitamin-d-are-associated-with-progression-of-subclinical-atherosclerotic-vascular-disease-in-peritoneal-dialysis-patients-a-prospective-multicenter-study
#18
Miguel Pérez Fontán, Mercè Borràs Sans, Maria Auxiliadora Bajo Rubio, Ana Rodriguez-Carmona, Angels Betriu, José Maria Valdivielso, Elvira Fernández
BACKGROUND: The prevalence of subclinical atherosclerosis and the main predictors of progression of this condition in patients undergoing peritoneal dialysis (PD) have been insufficiently investigated. OBJECTIVES AND METHOD: Following a prospective, multicenter, observational design, we studied 237 patients who were treated with PD for ≥3 months, without any clinical background of cardiovascular (CV) disease. Our objectives were the following: (1) to investigate the prevalence of subclinical atherosclerosis, as compared to a control group of age- and sex-matched healthy individuals, and (2) to disclose PD technique-related predictors of progression of disease during a 24-month follow-up period...
2017: Nephron
https://www.readbyqxmd.com/read/28225861/predictors-of-subclinical-atherosclerosis-evaluated-by-carotid-intima-media-thickness-in-asymptomatic-young-women-with-type-1-diabetes-mellitus
#19
Rosane Kupfer, Manuella Rangel Larrúbia, Isabela Bussade, Joana Rodrigues Dantas Pereira, Giovanna A Balarini Lima, Marcio Antonio Epifanio, Claudio Domenico Sahione Schettino, Denise Prado Momesso
Objective: This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods: The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria...
February 16, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28199074/inflammatory-markers-and-brain-derived-neurotrophic-factor-as-potential-bridges-linking-bipolar-disorder-and-cardiovascular-risk-among-adolescents
#20
Jessica K Hatch, Gustavo Scola, Omodele Olowoyeye, Jordan E Collins, Ana C Andreazza, Alan Moody, Anthony J Levitt, Bradley H Strauss, Krista L Lanctot, Benjamin I Goldstein
OBJECTIVE: Bipolar disorder (BD) is associated with increased rates of cardiovascular disease (CVD). Brain-derived neurotrophic factor (BDNF) and inflammatory markers are leading biomarkers in BD. We examined whether these biomarkers underlie the link between BD and CVD proxies among adolescents with bipolar spectrum disorders. METHODS: Subjects were 60 adolescents, 13-19 years old (40 with BD and 20 healthy controls [HCs]). Semistructured interviews determined diagnoses based on DSM-IV...
March 2017: Journal of Clinical Psychiatry
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