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Asymptomatic carotid atherosclerosis

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https://www.readbyqxmd.com/read/29432486/fractal-analysis-of-plaque-border-a-novel-method-for-the-quantification-of-atherosclerotic-plaque-contour-irregularity-is-associated-with-pro-atherogenic-plasma-lipid-profile-in-subjects-with-non-obstructive-carotid-stenoses
#1
Francesco Moroni, Marco Magnoni, Vittoria Vergani, Enrico Ammirati, Paolo G Camici
BACKGROUND AND AIMS: Plaque border irregularity is a known imaging characteristic of vulnerable plaques, but its evaluation heavily relies on subjective evaluation and operator expertise. Aim of the present work is to propose a novel fractal-analysis based method for the quantification of atherosclerotic plaque border irregularity and assess its relation with cardiovascular risk factors. METHODS AND RESULTS: Forty-two asymptomatic subjects with carotid stenosis underwent ultrasound evaluation and assessment of cardiovascular risk factors...
2018: PloS One
https://www.readbyqxmd.com/read/29425278/carotid-intima-media-thickness-and-silent-brain-infarctions-in-a-biracial-cohort-the-atherosclerosis-risk-in-communities-aric-study
#2
Melissa C Caughey, Ye Qiao, B Gwen Windham, Rebecca F Gottesman, Thomas H Mosley, Bruce A Wasserman
Background: Both hypertensive and atherosclerotic processes contribute to common carotid artery intima-media thickness (CCA-IMT). Elevated CCA-IMT may be indicative of subclinical cerebrovascular disease; however, its role in the absence of concomitant carotid artery plaque is uncertain, and few studies have examined associations in black populations. Materials and Methods: At cohort visit 3 (1993-1995) a subset of stroke-free participants (641 blacks and 702 whites, mean age 63) from the Atherosclerosis Risk in Communities (ARIC) study was imaged by brain MRI and carotid ultrasound...
February 7, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29424477/association-of-lipoprotein-associated-phospholipase-a2-mass-with-asymptomatic-cerebral-artery-stenosis
#3
Youxin Wang, Bin Zhou, Pingan Zhou, Yan Yao, Qinghua Cui, Yingping Liu, Jichun Yang, Shouling Wu, Xingquan Zhao, Yong Zhou
Cerebral artery stenosis (CAS) is the most important causes of ischaemic stroke. Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays 2 diverse roles in atherosclerosis (pro-inflammatory and anti-inflammatory), and the association between Lp-PLA2 mass and cardiovascular or cerebrovascular events is inconsistent among previous studies. A cross-sectional study including 2012 North Chinese adults aged ≥40 years was performed in 2010-2011 to investigate whether Lp-PLA2 mass is associated with asymptomatic cerebral artery stenosis (ACAS)...
February 9, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29412115/genetic-variations-and-subclinical-markers-of-carotid-atherosclerosis-in-patients-with-type-2-diabetes-mellitus
#4
Sara Mankoc Ramus, Danijel Petrovic
Atherosclerosis and its cardiovascular complications are the main cause of death in diabetic patients. Patients with diabetes mellitus have a greater than 10-fold risk of cardiovascular disease in their lifetime. The carotid intima-media thickness (cIMT), a surrogate marker for the presence and progression of atherosclerosis, predicts future cardiovascular events in asymptomatic subjects with type 2 diabetes mellitus (T2DM). This review focuses on genetic variants that contribute to the pathobiology of subclinical atherosclerosis in the setting of T2DM...
February 5, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29402147/carotid-im-gsm-is-better-than-imt-for-identifying-patients-with-multiple-arterial-disease
#5
Fisnik Jashari, Pranvera Ibrahimi, Elias Johansson, Christer Grönlund, Per Wester, Michael Y Henein
OBJECTIVE: Atherosclerosis is a systemic inflammatory disease that can affect more than one arterial bed simultaneously. The aim of this study was to determine the relationship between ultrasound markers of atherosclerosis and multiple arterial disease. DESIGN: We have included 87 currently asymptomatic carotid disease patients (mean age 69 ± 6 year, 34% females) in this study. Intima media thickness (IMT) and intima media-grey scale median (IM-GSM) were measured in the common carotid artery (CCA), and correlated with previous and/or current atherosclerotic vascular disease in the coronary, carotid and lower extremities...
February 6, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29366153/characteristics-of-carotid-atherosclerosis-and-brain-white-matter-hyperintensities-in-asymptomatic-patients-with-intermediate-stenosis
#6
Francesco Moroni, Enrico Ammirati, Marco Magnoni, Maria Assunta Rocca, Roberta Messina, Nicoletta Anzalone, Costantino De Filippis, Isabella Scotti, Francesca Besana, Pietro Spagnolo, Ornella Rimoldi, Roberto Chiesa, Andrea Falini, Massimo Filippi, Paolo Guido Camici
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29358636/association-between-h-type-hypertension-and-asymptomatic-extracranial-artery-stenosis
#7
Jia Zhang, Yanfang Liu, Anxin Wang, Dandan Wang, Ruixuan Jiang, Jiaokun Jia, Shengyun Chen, Xingquan Zhao
Asymptomatic extracranial artery stenosis (ECAS) is a well-known risk factor for stroke and H-type hypertension, which is defined as hypertension with hyperhomocysteinemia, is associated with cardio-cerebrovascular diseases. However, the impact of H-type hypertension on ECAS is mostly unknown. We designed this study to investigate the association between H-type hypertension and prevalence of ECAS. We included 2330 participants in this study and classified them into four groups: the control group without hypertension or hyperhomocysteinemia, isolated hypertension group, isolated hyperhomocysteinemia group and H-type hypertension group...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317141/serum-levels-of-osteopontin-predict-major-adverse-cardiovascular-events-in-patients-with-severe-carotid-artery-stenosis
#8
Federico Carbone, Fabio Rigamonti, Fabienne Burger, Aline Roth, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Aldo Pende, Aldo Bonaventura, Luca Liberale, Alessandra Vecchié, Franco Dallegri, François Mach, Fabrizio Montecucco
BACKGROUND: Inflammatory mediators in the blood stream and within plaques are key determinants in atherogenesis. Here, we investigated serum osteopontin (OPN) as a potential predictor of poor outcome in patients with severe carotid atherosclerosis. METHODS: Carotid plaques and serum were collected from patients asymptomatic (n=185) or symptomatic (n=40) for ischemic stroke. Plaques were stained for lipids, smooth muscle cells, neutrophils, M1 and M2 macrophage subsets and matrix metallopropteinase-9 (MMP-9)...
January 5, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29279888/prevalence-of-systemic-atherosclerosis-burdens-and-overlapping-stroke-etiologies-and-their-associations-with-long-term-vascular-prognosis-in-stroke-with-intracranial-atherosclerotic-disease
#9
Takao Hoshino, Leila Sissani, Julien Labreuche, Gregory Ducrocq, Philippa C Lavallée, Elena Meseguer, Céline Guidoux, Lucie Cabrejo, Cristina Hobeanu, Fernando Gongora-Rivera, Pierre-Jean Touboul, Philippe Gabriel Steg, Pierre Amarenco
Importance: Patients who have experienced stroke with intracranial atherosclerotic disease (ICAD) may also have concomitant atherosclerosis in different arterial beds and other possible causes for ischemic stroke. However, little is known about the frequency and prognostic effect of such overlapping diseases. Objectives: To describe the prevalence of systemic atherosclerotic burdens and overlapping stroke etiologies and their contributions to long-term prognoses among patients who have experienced stroke with ICAD...
December 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29239051/coronary-and-carotid-atherosclerosis-in-asymptomatic-male-marathon-runners
#10
Christof Burgstahler, Hans Cipowicz, Christoph Thomas, Christoph Schabel, Stefanie Mangold, Dominik Ketelsen, Claus D Claussen, Andreas M Niess, Ilias Tsiflikas
The aim of the study was to evaluate the diagnostic accuracy of carotid ultrasound (CU) to predict coronary atherosclerosis in asymptomatic male marathon runners. A total of 49 male marathon runners older than 45 years(mean age 53.3±7.2 years, range 45-74 years) received CU and cardiac CT angiography(CTA) including calcium scoring(CS). Results of CU and CTA were classified binary: 1. Absence of atherosclerosis and 2. presence of atherosclerosis. The extend of atherosclerosis was not primary end-point of the study...
December 14, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29196884/ultrasonographical-features-associated-with-progression-of-atherosclerosis-in-patients-with-moderate-internal-carotid-artery-stenosis
#11
Yumei Liu, Yang Hua, Ran Liu, Lili Wang, Chun Duan, Chen Ling, Xiaoguang Wu, Ovbiagele Bruce, Wuwei Feng
Carotid artery stenosis (CAS) is a leading cause of ischemic stroke. Plaque stabilization is a major management approach. Information about the ultrasonographical and clinical features associated with the progression of moderate internal carotid artery (ICA) stenosis (50-69%) could assist with prognostication and risk factor modifications. We evaluated 287 patients with moderate ICA stenosis (50-69%) and subsequently evaluated them at follow-up points at 12, 24, and 36 months. Patients were divided into three groups according to the degree of ICA stenosis: progression (70-99%, n = 48), stable (50-69%, n = 210), and regression (< 50%, n = 29)...
December 1, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29159396/association-of-nonalcoholic-fatty-liver-disease-with-lower-brain-volume-in-healthy-middle-aged-adults-in-the-framingham-study
#12
Galit Weinstein, Shira Zelber-Sagi, Sarah R Preis, Alexa S Beiser, Charles DeCarli, Elizabeth K Speliotes, Claudia L Satizabal, Ramachandran S Vasan, Sudha Seshadri
Importance: Nonalcoholic fatty liver disease (NAFLD) is a common condition that is most often asymptomatic. It is associated with metabolic syndrome, incident diabetes, carotid atherosclerosis, and endothelial dysfunction, conditions that in turn are strongly linked with brain damage and cognitive impairment. However, it is not known whether NAFLD is associated with structural brain measures in humans. Objective: To assess the association between prevalent NAFLD and brain magnetic resonance imaging (MRI) measures...
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29143147/-esc-guidelines-2017-on-peripheral-arterial-diseases-summary-of-the-most-important-recommendations-and-innovations
#13
C Espinola-Klein
The current European Society of Cardiology (ESC) guidelines on peripheral arterial diseases include recommendations on diagnostics and treatment of atherosclerotic manifestations in peripheral arteries. Because of the high coincidence of atherosclerosis in different arterial territories, screening for other atherosclerotic lesions is necessary in patients with clinical symptoms in one vascular bed. Consistent treatment of cardiovascular risk factors is important in all patients with peripheral atherosclerosis...
December 2017: Herz
https://www.readbyqxmd.com/read/29100226/subclinical-atherosclerosis-among-young-and-middle-aged-adults-using-carotid-intima-media-thickness-measurements
#14
Deborah L Jones, Violeta J Rodriguez, Maria L Alcaide, Nicole Barylski, Digna Cabral, Tatjana Rundek, Stephen M Weiss, Mahendra Kumar
OBJECTIVES: The presence of atherosclerotic plaque in the carotid arteries is a strong predictor of cardiovascular disease (CVD). Research and data on CVD risk have been derived primarily from individuals aged 55 years or older, and assessment of CVD risk among young and middle-aged adults seldom has been studied. The use of ultrasonography to measure carotid intima-media thickness (IMT) and carotid plaque appears to have utility to detect subclinical atherosclerosis in asymptomatic adults...
November 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/29059296/carotid-plaque-thickness-and-carotid-plaque-burden-predict-future-cardiovascular-events-in-asymptomatic-adult-americans
#15
Henrik Sillesen, Samantha Sartori, Benjamin Sandholt, Usman Baber, Roxana Mehran, Valentin Fuster
Introduction: Prediction of cardiovascular events improves using imaging, i.e. coronary calcium score and ultrasound assessment of carotid plaque. This study analysed the predictive value of two ultrasound measures of carotid plaque size: carotid plaque thickness and carotid and intima-media thickness (IMT). Methods and results: A total of 6102 asymptomatic persons underwent assessment of conventional risk factors and imaging by carotid ultrasound. Carotid plaque burden (cPB) and maximum carotid plaque thickness (cPTmax) were measured from 'cross-sectional sweep' video acquisition of the carotid artery...
October 20, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29030046/ideal-cardiovascular-health-and-incidence-of-carotid-plaque-among-middle-aged-and-elderly-adults
#16
Li Guo, Linggang Cheng, Wen He, Yi Ju, Xingquan Zhao
BACKGROUND: The ideal cardiovascular health (CVH) has been reported to be associated with reduced risk of ischemic stroke (IS). Atherosclerosis is a fundamental precursor in progression to IS. This study aimed to investigate the association of CVH score and atherosclerosis defined by carotid plaque in a community-based cohort. METHODS: Data came from the Asymptomatic Polyvascular Abnormalities Community study. After exclusions for missing data and original carotid plaque, 1938 subjects were included...
October 10, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29024265/effectiveness-of-a-handmade-new-carotid-catheter-in-transradial-carotid-angiography-a-comparison-with-conventional-multipurpose-catheters
#17
Yakup Balaban
OBJECTIVE: The incidence and severity of carotid atherosclerosis increases in proportion with coronary artery disease and its severity. A special catheter specifically used for transradial carotid angiography has not yet been marketed. In this study, we investigate the feasibility and safety of our carotid catheter, which was made by reshaping currently available catheters. METHODS: Between 2010 and 2017, a total of 921 patients with indications for carotid angiography were identified after angiographic examinations and included in the study...
October 11, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28990089/kinin-b1-receptor-as-a-novel-prognostic-progression-biomarker-for-carotid-atherosclerotic-plaques
#18
Tiantian Liu, Hengfang Liu, Li Feng, Bo Xiao
Stroke caused by atherosclerosis remains a leading cause of morbidity and mortality worldwide, associated with carotid plaque rupture and inflammation progression. However, the inflammatory biomarkers which aid in predicting the future course of plaques are less detailed. The present study investigated the association between plaque vulnerable and inflammatory biomarkers using blood and plaque specimens. Carotid plaque specimens were obtained from 80 patients following stroke, 14 patients suffering from transient ischaemic attack and 17 asymptomatic patients that underwent carotid endarterectomy...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28980510/sensitivities-of-in-vivo-markers-of-arterial-organ-damage-in-patients-with-peripheral-atherosclerosis
#19
Martina Frick, Frederic Baumann, Beate Sick, Ian B Wilkinson, Beatrice Amann-Vesti, Marc Husmann
BACKGROUND: Biomarkers of vascular diseases such as ankle-brachial index (ABI), peripheral pulse pressure (pPP), central pulse pressure (cPP), and pulse wave velocity (PWV) allow assessment of arterial organ damage (AOD). However, the utility of markers other than ABI in patients with peripheral arterial disease (PAD), which are also associated with a significant increase of cardiovascular events, remains unclear. PATIENTS AND METHODS: Asymptomatic (n = 21) and symptomatic patients (n = 46) with a positive sonography for PAD or history of lower limb revascularization were included...
October 5, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28877387/recommendations-for-low-grade-carotid-stenosis-follow-up-based-on-a-single-institution-database
#20
Garrett M Bennett, Edward I Bluth, Michael L Larson, Qingyang Luo
OBJECTIVES: The purpose of this study was to determine the incidences and rates of progression of varying degrees of carotid stenosis that do not require intervention according to the Asymptomatic Carotid Atherosclerosis Study, the European Carotid Surgery Trial, and the North American Symptomatic Carotid Endarterectomy Trial, and from this information, to provide evidence-based recommendations for follow-up imaging. METHODS: A retrospective review was performed of all carotid ultrasound examinations performed at a single institution from January 1995 through April 2015...
September 6, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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