keyword
https://read.qxmd.com/read/38537010/effect-of-egcg-based-paste-as-intracanal-dressing-in-mmps-2-and-9-expression-in-dog-s-periapical-lesions
#1
JOURNAL ARTICLE
Andiara De Rossi, Tadeu Pradela, Fernanda Souza Liévana, Raquel Assed Bezerra Segato, Jorge Esquiche León, Léa Assed Bezerra da Silva, Paulo Nelson-Filho
High expression of MMP-2 and MMP-9 in periapical lesions plays an important role in the degradation of the extracellular matrix. This study aimed to investigate the effect of epigallocatechin-3-gallate (EGCG)-based endodontic paste as an intracanal dressing on the expression of MMP-2 and MMP-9 in periapical lesions. Periapical lesions were experimentally induced in 35 mature beagle dog premolars randomly divided into healthy teeth, untreated periapical lesions, periapical lesions treated in a single session (control groups), and periapical lesions treated in two sessions with EGCG or calcium hydroxide-based pastes (experimental groups)...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38536640/genetically-predicted-apolipoprotein-e-levels-with-the-risk-of-panvascular-diseases-a-mendelian-randomization-study
#2
JOURNAL ARTICLE
Yi-Ming Shi, Dian Ou, Jia-Ting Li, Le Bao, Xiao-Dan Liu, Wei Zhang, Huang Ding
The aim of this study was to comprehensively assess the causal relationship between the overall genetic effect of circulating ApoE levels and panvascular lesions using newer genome-wide association data and two-sample bidirectional Mendelian randomization (MR) analysis. Two-way MR using single-nucleotide polymorphisms of circulating ApoE as instrumental variables was performed using the highest-priority Genome-wide association study (GWAS) data, with factor-adjusted and data-corrected statistics, to estimate causal associations between circulating ApoE levels and 10 pan-vascular diseases in > 500,000 UK Biobank participants, > 400,000 participants of Finnish ancestry, and numerous participants in a consortium of predominantly European ancestry...
March 27, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38536011/evaluation-of-diagnostic-value-of-doppler-ultrasound-in-the-diagnosis-of-malignant-breast-masses
#3
JOURNAL ARTICLE
Bahareh Mehdikhani, Milad Benam, Afrooz Moradkhani, Ayda Roostaee, Seyedeh Sabahat Bahman, Pooyan Barmayoon, Ghazaleh Dezyani, Zeinab Safarpour Lima
Breast cancer is the leading cause of cancer mortality in women, and it is on the rise in Iran. Therefore, an early-stage diagnosis of breast cancer is of critical importance. Because ultrasound is one of the available, inexpensive, and minimally invasive techniques for distinguishing malignant from benign masses, a comparison of conventional ultrasound, color Doppler, and spectral Doppler findings can be useful. The purpose of this study was to determine the diagnostic value of sonographic indices, specifically Doppler parameters, in identifying the nature of breast masses...
March 26, 2024: European Journal of Translational Myology
https://read.qxmd.com/read/38535082/comparison-of-tissue-factors-in-the-ontogenetic-aspects-of-human-cholesteatoma
#4
JOURNAL ARTICLE
Kristaps Dambergs, Gunta Sumeraga, Māra Pilmane
BACKGROUND: An acquired cholesteatoma is a benign but locally aggressive lesion in the middle ear. It is characterized by chronic inflammation and the destruction of surrounding bone. Therefore, the aim of this study was to compare defensins HβD-2 and HβD-4; pro- and anti-inflammatory cytokines IL-1α and IL-10; proliferation marker Ki-67; transcription factor NF-κβ; angiogenetic factor VEGF; Sonic hedgehog gene protein SHH; and remodeling factors MMP-2, MMP-9, TIMP-2, and TIMP-4 in adult and pediatric cholesteatoma tissue, and to compare these groups with control skin tissue...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38532846/predicting-endothelium-dependent-diastolic-function-fmd-and-its-correlation-with-the-degree-of-coronary-artery-disease-cad-and-plaque-vulnerability-for-cardiovascular-events
#5
JOURNAL ARTICLE
Guangming Zhang, Jing Yang, Hanghang Xing, Hongning Yin, Guoqing Gu
OBJECTIVE: This study aims to investigate the correlation between vascular endothelium-dependent diastolic function (FMD) and the degree of coronary artery disease (CAD), plaque vulnerability, and its predictive value for cardiovascular events. METHODS: Initially, patients (n=100) who were admitted from January 2020 to January 2021 and intended to undergo percutaneous coronary intervention (PCI) were selected. Further, FMD in all patients was determined before the procedure and divided into a high-FMD group (≥4...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38532801/improved-visualization-of-median-ulnar-nerves-and-small-branches-in-the-wrist-and-palm-using-contrast-enhanced-magnetic-resonance-neurography
#6
JOURNAL ARTICLE
Jiamin Kang, Wenjun Wu, Xiangchuang Kong, Yu Su, Dingxi Liu, Chungao Li, Nan Gao, Youzhi Wang, Chuansheng Zheng, Yuxiong Weng, Lixia Wang
BACKGROUND: Magnetic resonance imaging of peripheral nerves in the wrist and palm is challenging due to the small size, tortuous course, complex surrounding tissues, and accompanying blood vessels. The occurrence of carpal palmar lesions leads to edema, swelling, and mass effect, which may further interfere with the display and identification of nerves. OBJECTIVE: To evaluate whether contrast-enhanced magnetic resonance neurography (ceMRN) improves the visualization of the morphology and pathology of the median, ulnar nerves, and their small branches in the wrist and palm...
2024: Therapeutic Advances in Neurological Disorders
https://read.qxmd.com/read/38532714/multimodal-imaging-of-a-case-of-retinal-cavernous-hemangioma
#7
JOURNAL ARTICLE
Fanyu Guan, Wenting Luo, Guimei Xia
PURPOSE: Herein, we reported a case of retinal cavernous hemangioma (RCH) and its multimodal imaging. CASE PRESENTATION: Many grape-like lesions were incidentally found along the distal portion of the vascular arcade in a 23-year-old man's superonasal quadrant of the retina. The best-corrected visual acuity was 20/20 in both eyes. The fluorescein angiography showed saccular lesions that slowly filled with hypofluorescence in the early stage and clusters of aneurysms with hyperfluorescence and a special "fluorescein cap" appearance in the late stage...
March 27, 2024: European Journal of Ophthalmology
https://read.qxmd.com/read/38532338/carbon-ion-radiotherapy-for-hepatocellular-carcinoma-with-major-vascular-invasion-a-retrospective-cohort-study
#8
JOURNAL ARTICLE
Takashi Kaneko, Hirokazu Makishima, Masaru Wakatsuki, Yuichi Hiroshima, Toshiaki Matsui, Shigeo Yasuda, Naomi Nagatake Okada, Kenji Nemoto, Hiroshi Tsuji, Shigeru Yamada, Masaru Miyazaki
BACKGROUND: Macroscopic vascular invasion (MVI) significantly impacts survival in patients with hepatocellular carcinoma (HCC), warranting systemic therapy over locoregional therapy. Despite novel approaches, HCC with MVI has a poor prognosis compared to early-to intermediate-stage HCC. This study aimed to evaluate the safety and efficacy of carbon-ion radiotherapy (C-ion RT) for HCC characterized by MVI. METHODS: This retrospective cohort study evaluated HCC patients with MVI treated using C-ion RT with a dose of 45...
March 26, 2024: BMC Cancer
https://read.qxmd.com/read/38532071/dysregulated-cellular-metabolism-in-atherosclerosis-mediators-and-therapeutic-opportunities
#9
REVIEW
Chad Stroope, Felix Sebastian Nettersheim, Brian Coon, Alexandra C Finney, Martin A Schwartz, Klaus Ley, Oren Rom, Arif Yurdagul
Accumulating evidence over the past decades has revealed an intricate relationship between dysregulation of cellular metabolism and the progression of atherosclerotic cardiovascular disease. However, an integrated understanding of dysregulated cellular metabolism in atherosclerotic cardiovascular disease and its potential value as a therapeutic target is missing. In this Review, we (1) summarize recent advances concerning the role of metabolic dysregulation during atherosclerosis progression in lesional cells, including endothelial cells, vascular smooth muscle cells, macrophages and T cells; (2) explore the complexity of metabolic cross-talk between these lesional cells; (3) highlight emerging technologies that promise to illuminate unknown aspects of metabolism in atherosclerosis; and (4) suggest strategies for targeting these underexplored metabolic alterations to mitigate atherosclerosis progression and stabilize rupture-prone atheromas with a potential new generation of cardiovascular therapeutics...
March 26, 2024: Nature metabolism
https://read.qxmd.com/read/38532042/a-parametric-study-of-the-effect-of-3d-plaque-shape-on-local-hemodynamics-and-implications-for-plaque-instability
#10
JOURNAL ARTICLE
Shaolie S Hossain, Michael J Johnson, Thomas J R Hughes
The vast majority of heart attacks occur when vulnerable plaques rupture, releasing their lipid content into the blood stream leading to thrombus formation and blockage of a coronary artery. Detection of these unstable plaques before they rupture remains a challenge. Hemodynamic features including wall shear stress (WSS) and wall shear stress gradient (WSSG) near the vulnerable plaque and local inflammation are known to affect plaque instability. In this work, a computational workflow has been developed to enable a comprehensive parametric study detailing the effects of 3D plaque shape on local hemodynamics and their implications for plaque instability...
March 26, 2024: Biomechanics and Modeling in Mechanobiology
https://read.qxmd.com/read/38531932/correlation-of-shear-wave-elastography-stiffness-and-apparent-diffusion-coefficient-values-with-tumor-characteristics-in-breast-cancer
#11
JOURNAL ARTICLE
Mi-Ri Kwon, Inyoung Youn, Eun Sook Ko, Seon-Hyeong Choi
We aimed to investigate the correlation between shear-wave elastography (SWE) and apparent diffusion coefficient (ADC) values in breast cancer and to identify the associated characteristics. We included 91 breast cancer patients who underwent SWE and breast MRI prior to surgery between January 2016 and November 2017. We measured the lesion's mean (Emean ) and maximum (Emax ) elasticities of SWE and ADC values. We evaluated the correlation between SWE, ADC values and tumor size. The mean SWE and ADC values were compared for categorical variable of the pathological/imaging characteristics...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531544/application-of-bedside-hints-abcd-2-score-and-truncal-ataxia-to-differentiate-cerebellar-brainstem-stroke-from-vestibular-neuritis-in-the-emergency-room
#12
JOURNAL ARTICLE
Xinmin Liu, Zhaoxia Li, Yi Ju, Xingquan Zhao
BACKGROUND AND PURPOSE: Acute vestibular syndrome (AVS) typically manifests as isolated dizziness or vertigo with no apparent neurological impairments. However, distinguishing life-threatening stroke from innocuous peripheral vestibular lesions in the emergency room (ER) remains challenging. This study aimed to explore the ability of the head impulse-nystagmus-test of skew (HINTS) combined with truncal ataxia or ABCD2 score to differentiate stroke from peripheral vestibular disease in patients with AVS in the ER...
March 25, 2024: Stroke and Vascular Neurology
https://read.qxmd.com/read/38531474/an-in-depth-analysis-of-the-artery-of-salmon-anatomy-and-neurosurgical-implications
#13
REVIEW
Oday Atallah, Yasser F Almealawy, Amr Badary, Alan Hernández-Hernández, Wireko Andrew Awuah, Vivek Sanker, Bipin Chaurasia, Giuseppe E Umana
BACKGROUND: Michel Salmon was a prominent person in the field of plastic surgery during the early 20th century. His pioneering work contributed significantly to our understanding of human anatomy, particularly with the identification of the Artery of Salmon. The objective of this study is to thoroughly investigate the AOS by conducting a comprehensive literature review, providing insights into its anatomy and surgical implications. MATERIAL AND METHODS: This review was undertaken after a thorough examination of literature encompassing papers about the AOS...
March 24, 2024: World Neurosurgery
https://read.qxmd.com/read/38530384/posterior-cerebral-artery-pca-accessory-pca-hyperplastic-anterior-choroidal-artery-anastomosis-detected-on-magnetic-resonance-angiography
#14
JOURNAL ARTICLE
Akira Uchino, Kazuo Tokushige
PURPOSE: To describe a case of posterior cerebral artery (PCA)-accessory PCA (hyperplastic anterior choroidal artery) anastomosis detected on magnetic resonance angiography. METHODS: A 76-year-old man with a history of cerebral infarction underwent cranial magnetic resonance (MR) imaging and MR angiography of the intracranial region for the evaluation of brain and vascular lesions. The MR machine was a 3-Tesla scanner. MR angiography was performed using a standard three-dimensional time-of-flight technique...
March 26, 2024: Surgical and Radiologic Anatomy: SRA
https://read.qxmd.com/read/38529369/diagnosis-of-benign-and-malignant-peripheral-lung-lesions-based-on-a-feature-model-constructed-by-the-random-forest-algorithm-for-grayscale-and-contrast-enhanced-ultrasound
#15
JOURNAL ARTICLE
Hong Wei, Yichun Wang, Jinyao Li, Yanyan Wang, Longdi Lu, Jiawei Sun, Xiaolei Wang
RATIONALE AND OBJECTIVES: To construct a predictive model for benign and malignant peripheral pulmonary lesions (PPLs) using a random forest algorithm based on grayscale ultrasound and ultrasound contrast, and to evaluate its diagnostic value. MATERIALS AND METHODS: We selected 254 patients with PPLs detected using chest lung computed tomography between October 2021 and July 2023, including 161 malignant and 93 benign lesions. Relevant variables for judging benign and malignant PPLs were screened using logistic regression analysis...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38529094/visual-vertical-neglect-in-acquired-brain-injury-a-systematic-review
#16
Pasquale Moretta, Nicola Davide Cavallo, Eleonora Fonzo, Antonio Maiorino, Cesario Ferrante, Pasquale Ambrosino, Cinzia Femiano, Gabriella Santangelo, Laura Marcuccio
Vertical neglect represents a visuospatial deficit occurring as a possible consequence of acquired brain injury (ABI). Differently from unilateral spatial neglect on horizontal space, vertical neglect is poorly studied in the literature and rarely assessed in clinical practice. In the available studies, the terms "radial," "vertical," and "altitudinal" neglect are often used interchangeably, although they do not describe the same spatial dimension. "Altitudinal" and "vertical" refer to the sagittal plane, whereas "radial" refers to the transverse plane...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38528467/characteristics-of-high-frame-frequency-contrast-enhanced-ultrasound-in-renal-tumors
#17
JOURNAL ARTICLE
WeiPing Zhang, JingLing Wang, Li Chen
OBJECTIVE: This study aims to analyze the characteristics of high frame rate contrast-enhanced ultrasound (H-CEUS) in renal lesions and to improve the ability for differential diagnosis of renal tumors. METHODS: A total of 140 patients with renal lesions underwent contrast-enhanced ultrasound (CEUS) examination in the First Affiliated Hospital of Nanchang University from July 2022 to July 2023. Based on the tumor pathology and the results of enhanced CT, tumor patients were divided into malignant and benign groups...
March 25, 2024: BMC Medical Imaging
https://read.qxmd.com/read/38527912/retinal-changes-in-patients-with-covid-19-and-different-expressiveness-of-metabolic-changes
#18
JOURNAL ARTICLE
Kateryna Hutsaliuk, Nataliia Skalska, Nadiia Ulianova
AIMS:  To study the relationship between the severity of COVID-induced metabolic changes and the structure and frequency of retinal changes, according to funduscopy data in patients with different clinical courses of COVID-19. MATERIALS AND METHODS:  117 patients with COVID-19 were examined. While examining patients, severity of the course of COVID-19, the expressiveness of changes in the metabolic status were determined; fundus image registration was performed with portable fundus cameras Pictor Plus Fundus Camera and VistaView (Volk Optical)...
2024: Ceská a Slovenská Oftalmologie
https://read.qxmd.com/read/38525523/numerous-multinucleated-giant-cells-in-cutaneous-epithelioid-angiosarcoma-and-pulmonary-metastasis-a-unique-observation-with-potential-diagnostic-pitfalls
#19
Yushi Kanatani, Yasuhiro Mitsui, Kohei Ogawa, Maiko Takeda, Fumi Miyagawa, Satoru Shinkuma, Takeshi Kawaguchi, Takaya Fukumoto, Hideo Asada
The histopathologic diagnosis of poorly differentiated cutaneous angiosarcoma can be challenging. We report a case of cutaneous epithelioid angiosarcoma with numerous multinucleated giant cells (MGCs) developing pulmonary metastasis. A 79-year-old man presented with a red-purple plaque on the scalp. A skin biopsy revealed epithelioid cell proliferation, admixed with numerous MGCs, and background hemorrhage. Vascular spaces were focally present and lined by atypical endothelial cells, including MGCs. Immunohistochemically, tumor cells, including MGCs, were positive for CD31, D2-40, and ERG...
March 25, 2024: Journal of Cutaneous Pathology
https://read.qxmd.com/read/38525374/extensive-stage-small-cell-lung-cancer-with-cystic-brain-metastases-a-report-of-two-cases
#20
Fei Cai, Di Wu, Junling Liu, Shuxi Song, Jingyu Li, Zhendong Zheng, Long Xu
OBJECTIVE: Cystic brain metastases (BMs) are rare in small cell lung cancer (SCLC), and there are limited data on the treatment and prognosis of cystic BMs. Whole brain radiotherapy has been the mainstay for BMs since several years. Immune checkpoint inhibitors in extensive stage small cell lung cancer (ES-SCLC) have been shown to be suitable for patients who experienced better overall survival and progress-free survival and have been approved as the first-line treatment for ES-SCLC. In this report, we described two ES-SCLC patients developed cystic BMs after immunotherapy, after which the patients continued to treat the primary lesion with immune checkpoint inhibitors and the cystic BMs with radiotherapy...
2024: Cancer Management and Research
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