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https://www.readbyqxmd.com/read/28931265/diagnostic-and-interventional-optical-angioscopy-in-ex-vivo-carotid-arteries
#1
Luis E Savastano, Neeraj Chaudhary, Carlos Murga-Zamalloa, Michael Wang, Thomas Wang, B Gregory Thompson
BACKGROUND: Angioscopy - or endovascular endoscopy - is a catheter-based technique employing a flexible fiberoptic angioscope to directly visualize arterial lumen. Poor resolution and excessive stiffness of pre-existent angioscopes limited their use clinically. Recent advances resulted in novel fused optical fiber bundle angioscopes with improved flexibility and imaging resolution. Use of these devices in endovascular neurosurgery is still largely unexplored. OBJECTIVE: To evaluate image quality and feasibility of optical angioscopes for diagnostic and interventional neuro-angioscopy in carotid arteries of human cadavers...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28931254/cavernomas-and-arteriovenous-malformations-in-the-mesial-temporal-region-microsurgical-anatomy-and-approaches
#2
Alvaro Campero, Pablo Ajler, Carlos Rica, Albert Rhoton
BACKGROUND: The mesial temporal region (MTR) is located deep in the temporal lobe and it is surrounded by important vascular and nervous structures that should be preserved during surgery. OBJECTIVE: To describe microsurgical anatomy and approaches to the MTR in relation to cavernomas and arteriovenous malformations (AVMs). METHODS: Five formalin-fixed and red silicone-embedded heads of adult cadavers were used for this study. Between January 2003 and June 2014, 7 patients with cavernomas and 6 patients with AVMs in the MTR underwent surgery...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28931250/minimally-invasive-transpalpebral-endoscopic-assisted-amygdalohippocampectomy
#3
Mauricio Mandel, Eberval Gadelha Figueiredo, Suzana Abramovicz Mandel, Rafael Tutihashi, Manoel Jacobsen Teixeira
BACKGROUND: Although anterior temporal lobectomy may be a definitive surgical treatment for epileptic patients with mesial temporal sclerosis, it often results in verbal, visual, and cognitive dysfunction. Studies have consistently reported the advantages of selective procedures compared with a standard anterior temporal lobectomy, mainly in terms of neuropsychological outcomes. OBJECTIVE: To describe a new technique to perform a selective amygdalohippocampectomy (SAH) through a transpalpebral approach with endoscopic assistance...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28930831/accessory-spleen-located-in-the-right-parietal-peritoneum-the-first-case-report
#4
Shao-Yan Xu, Ke Sun, Hai-Yang Xie, Lin Zhou, Shu-Sen Zheng, Weilin Wang
RATIONALE: Accessory spleen is a congenital abnormality caused by failure of the splenic anlage to fuse during embryology. The presence of an accessory spleen located in the parietal peritoneum has not been reported so far, and an accessory spleen situated on the right side is extremely rare. In the present study, we describe the first case of an accessory spleen located in the right parietal peritoneum. PATIENTS CONCERNS: A 65-year-old man, presented with pain in his left abdomen for 1 month...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930802/morphologic-features-associated-with-fibrotic-scarring-after-anti-vascular-endothelial-growth-factor-therapy-in-polypoidal-choroidal-vasculopathy
#5
Jae Hui Kim, Young Suk Chang, Jong Woo Kim, Chul Gu Kim, Dong Won Lee, Ye Ji Kim
PURPOSE: To investigate morphologic features associated with fibrotic scarring after anti-vascular endothelial growth factor therapy in polypoidal choroidal vasculopathy (PCV). METHODS: This retrospective study included 293 patients who had been diagnosed with PCV and treated with anti-vascular endothelial growth factor monotherapy during a 12-month follow-up period. Associations of morphologic features, including type of PCV, location of the polypoidal lesion, greatest linear dimension, largest polyp diameter, choroidal vascular hyperpermeability, pigment epithelial detachment, intraretinal fluid, and subretinal hyperreflective material (SHRM) with fibrotic scar at 12 months were analyzed...
September 19, 2017: Retina
https://www.readbyqxmd.com/read/28927896/niacin-and-heart-disease-prevention-engraving-its-tombstone-is-a-mistake
#6
REVIEW
Harold Robert Superko, Xue-Qiao Zhao, Howard N Hodis, John R Guyton
Niacin (nicotinic acid) has been used for primary and secondary coronary heart disease prevention for over 40 years. Until recently clinical trials incorporating niacin as part of an intervention strategy consistently demonstrated reduction in clinical events and lesion improvement, including ≥6% absolute mortality reduction. Two large clinical event trials in 2011 (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes) and 2014 (Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events) concluded that niacin added to statin therapy did not provide clinical event benefit over statin alone...
August 24, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28927449/beyond-classic-dermoscopic-patterns-of-dermatofibromas-a-prospective-research-study
#7
Awatef Kelati, Nima Aqil, Hanane Baybay, Salim Gallouj, Fatima Zahra Mernissi
BACKGROUND: The usual stereotypical dermoscopic pattern associated with dermatofibromas is a pigment network and central white patch. However, this pattern may be difficult to diagnose in some variant cases. We aimed to describe dermoscopic patterns of dermatofibroma according to its histopathological subtypes, with special emphasis on new and rare dermoscopic features. METHODS: This prospective study, which was conducted between September 2015 and May 2016 in the Department of Dermatology, University Hospital Hassan II, Fez, Morocco, included 100 cases of dermatofibroma confirmed on clinical and histological grounds...
September 20, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28927207/surgical-approaches-to-the-temporal-horn-an-anatomic-analysis-of-white-matter-tract-interruption
#8
Paulo A S Kadri, Jean G de Oliveira, Niklaus Krayenbühl, Ugur Türe, Evandro P L de Oliveira, Ossama Al-Mefty, Guilherme C Ribas
BACKGROUND: Surgical access to the temporal horn is necessary to treat tumors and vascular lesions, but is used mainly in patients with mediobasal temporal epilepsy. The surgical approaches to this cavity fall into 3 primary categories: lateral, inferior, and transsylvian. The current neurosurgical literature has underestimated the interruption of involved fiber bundles and the correlated clinical manifestations. OBJECTIVE: To delineate the interruption of fiber bundles during the different approaches to the temporal horn...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28926646/vascular-hypoperfusion-in-acute-optic-neuritis-is-a-potentially-new-neurovascular-model-for-demyelinating-diseases
#9
Ta-Ching Chen, Chao-Yuan Yeh, Chao-Wen Lin, Chung-May Yang, Chang-Hao Yang, I-Hung Lin, Pao-Yang Chen, Jung-Yu Cheng, Fung-Rong Hu
PURPOSE: Optic neuritis is highly correlated with multiple sclerosis and is a major cause of acute visual loss and long-term neuronal degeneration. Primary cerebral hypoperfusion has been reported in brain demyelinating diseases. This study investigated whether peripapillary perfusion is changed in patients with acute optic neuritis (AON). METHODS: This three-year cohort study was conducted from September 1 2012, to August 31, 2015. Two hundred and forty-one patients with non-glaucomatous acute optic neuropathy were screened, and 42 non-highly myopic patients who had suffered their first episode of unilaterally idiopathic AON were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28926607/the-novel-mineralocorticoid-receptor-antagonist-finerenone-attenuates-neointima-formation-after-vascular-injury
#10
Jochen Dutzmann, Robert-Jonathan Musmann, Marco Haertlé, Jan-Marcus Daniel, Kristina Sonnenschein, Andreas Schäfer, Peter Kolkhof, Johann Bauersachs, Daniel G Sedding
BACKGROUND: The novel nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone holds promise to be safe and efficient in the treatment of patients with heart failure and/or chronic kidney disease. However, its effects on vascular function remain elusive. PURPOSE: The aim of this study was to determine the functional effect of selective MR antagonism by finerenone in vascular cells in vitro and the effect on vascular remodeling following acute vascular injury in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28926190/an-8-year-follow-up-of-anti-vascular-endothelial-growth-factor-treatment-with-a-treat-and-extend-modality-for-neovascular-age-related-macular-degeneration
#11
Karina Berg, Anca B Roald, Jesintha Navaratnam, Ragnheiður Bragadóttir
PURPOSE: To investigate long-term visual results of treatment with anti-vascular endothelial growth factor (VEGF) agents for neovascular age-related macular degeneration (nAMD) following a treat-and-extend regimen. METHODS: Retrospective review of 155 patients who initiated treatment with bevacizumab for nAMD in one eye. At the final 8-year visit, 40 patients (26%) remained for follow-up. Mean change in best-corrected visual acuity (BCVA) was calculated compared to baseline values...
September 19, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28925057/serum-vascular-endothelial-growth-factor-a-levels-reflect-itch-severity-in-mycosis-fungoides-and-s%C3%A3-zary-syndrome
#12
Minami Sakamoto, Tomomitsu Miyagaki, Hiroaki Kamijo, Tomonori Oka, Naomi Takahashi, Hiraku Suga, Ayumi Yoshizaki, Yoshihide Asano, Makoto Sugaya, Shinichi Sato
Angiogenesis is an important step to support progression of malignancies, including mycosis fungoides (MF) and Sézary syndrome (SS). Vascular endothelial growth factor (VEGF)-A, a key player in angiogenesis, is secreted by tumor cells of MF/SS and its expression levels in lesional skin correlated with disease severity. In this study, we examined serum VEGF-A levels in MF/SS patients. Serum VEGF-A levels were elevated in patients with erythrodermic MF/SS and the levels decreased after treatment. Importantly, serum VEGF-A levels positively correlated with markers for pruritus...
September 19, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28924363/thrombospondin-1-gene-deficiency-worsens-the-neurological-outcomes-of-traumatic-brain-injury-in-mice
#13
Chongjie Cheng, Zhanyang Yu, Song Zhao, Zhengbu Liao, Changhong Xing, Yinghua Jiang, Yong-Guang Yang, Michael J Whalen, Eng H Lo, Xiaochuan Sun, Xiaoying Wang
Background: Thrombospondin-1 (TSP-1) is an extracellular matrix protein that plays multiple physiological and pathophysiological roles in the brain. Experimental reports suggest that TSP-1 may have an adverse role in neuronal function recovery under certain injury conditions. However, the roles of TSP-1 in traumatic brain injury (TBI) have not been elucidated. In this study we for the first time investigated the roles of TSP-1 in a controlled cortical impact (CCI) model of TBI in TSP-1 knockout (TSP-1 KO) and wild type (WT) mice...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28923299/masson-s-tumor-revealed-by-an-intracerebral-hematoma-case-report-and-a-review-of-the-literature
#14
C Salaud, D Loussouarn, K Buffenoir, T Riem
We report the case of a 56-year-old woman who underwent total resection of a Masson's tumor or intravascular papillary endothelial hyperplasia (IPEH), which was discovered due to a left temporal intracerebral hematoma revealed by aphasia. IPEH is more often localized on cutaneous and subcutaneous locations, intracranial IPEH are rare and only approximately twenty cases have been published to date. These tumors are a benign vascular lesion composed of papillary intravascular proliferation of epithelial cellular associated thrombosis with fibrin deposits responsible for vascular lumen obliteration...
September 15, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28923099/whole-blood-gene-expression-and-white-matter-hyperintensities
#15
Honghuang Lin, Claudia Satizabal, Zhijun Xie, Qiong Yang, Tianxiao Huan, Roby Joehanes, Chengping Wen, Peter J Munson, Alexa Beiser, Daniel Levy, Sudha Seshadri
BACKGROUND: White matter hyperintensities (WMH) are an important biomarker of cumulative vascular brain injury and have been associated with cognitive decline and an increased risk of dementia, stroke, depression, and gait impairments. The pathogenesis of white matter lesions however, remains uncertain. The characterization of gene expression profiles associated with WMH might help uncover molecular mechanisms underlying WMH. METHODS: We performed a transcriptome-wide association study of gene expression profiles with WMH in 3248 participants from the Framingham Heart Study using the Affymetrix Human Exon 1...
September 18, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28922881/intraoperative-flow-800-analysis-for-intramedullary-cystic-lesion-a-technical-case-report
#16
Masahiro Sawada, Toshihiro Munemitsu, Masato Hojo
BACKGROUND AND IMPORTANCE: During intramedullary lesion surgery, the lesion site and the posterior median sulcus (PMS) should be accurately identified prior to myelotomy to avoid severe injury of the posterior funiculus. However, intramedullary lesions are fundamentally invisible until the myelotomy is performed. Furthermore, the PMS location is frequently unclear due to lesion-induced swelling or distortion of the spinal cord. Intraoperative indocyanine green videoangiography (ICG-VA) followed by FLOW 800 analysis, which shows vascularization of the spinal parenchyma, may provide a solution for these problems in specific cases...
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28922462/vaginal-mesh-repair-systems-for-pelvic-organ-prolapse-anatomical-study-comparing-transobturator-trangluteal-versus-single-incision-techniques
#17
Giuseppe Campagna, Giovanni Panico, Andrea Morciano, Pierre Gadonneix, Vincent Delmas, Mauro Cervigni, Alfredo Ercoli, Giovanni Scambia
INTRODUCTION: The present study aim to compare the anatomic landmarks of two pelvic floor repair systems, in order to identify the potential neurovascular lesions related to different mesh fixation techniques. METHODS: Abdominal and perineal dissections of 10 fresh cadavers after prolapse surgery using transobturator/transgluteal versus single incision techniques. Neuro-vascular structures of obturator region and perineum were isolated. Distances between needles and anatomical structures were measured...
September 18, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28920546/blood-supply-and-vascularity-of-the-glenoid-labrum-its-clinical-implications
#18
Abduelmenem Alashkham, Abdulrahman Alraddadi, Paul Felts, Roger Soames
BACKGROUND: Tears of the glenoid labrum are common after dislocation of the glenohumeral joint. The outcome for healing or surgical reconstruction of the glenoid labrum relies on the extent of its vascularization. This study aims to evaluate the glenoid labrum blood supply and to determine its regional vascularity. MATERIALS AND METHODS: A total of 140 shoulders (30 male and 40 female cadavers) were examined: mean age 81.5 years, range 53-101 years. All blood vessels around the glenohumeral joint were dissected and recorded...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28920098/the-il-1ri-co-receptor-tilrr-frem1%C3%A2-isoform-2-controls-aberrant-inflammatory-responses-and-development-of-vascular-disease
#19
Sarah A Smith, Andriy O Samokhin, Mabruka Alfadi, Emer C Murphy, David Rhodes, W Mike L Holcombe, Endre Kiss-Toth, Robert F Storey, Siu-Pok Yee, Sheila E Francis, Eva E Qwarnstrom
Expression of the interleukin-1 receptor type I (IL-1RI) co-receptor Toll-like and interleukin-1 receptor regulator (TILRR) is significantly increased in blood monocytes following myocardial infarction and in the atherosclerotic plaque, whereas levels in healthy tissue are low. TILRR association with IL-1RI at these sites causes aberrant activation of inflammatory genes, which underlie progression of cardiovascular disease. The authors show that genetic deletion of TILRR or antibody blocking of TILRR function reduces development of atherosclerotic plaques...
August 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/28919613/non-invasively-measured-carotid-artery-intima-medial-thickness-may-be-a-more-useful-marker-of-coronary-artery-disease-in-diabetic-than-non-diabetic-patients
#20
C M Ahmed, M K Hasan, B C Goswami, S K Banerjee, M F Rahman, H H Samira, D F Osmani, M N Hasan
Carotid intima-medial thickness has long been proposed as a surrogate marker of atherosclerotic vascular disease in other vascular beds, most notably the coronary arteries with its practical implications. This observational study aimed at exploring the relationship of a hypothetical stronger relationship of carotid intima-medial thickness with coronary artery disease in diabetic patients than non-diabetic counterparts. Thirty diabetic patients and 74 non-diabetic patients who were referred for coronary angiogram in the Departments of Cardiology Bangabandhu Sheikh Mujib Medical University and Combined Military Hospital, Dhaka Cantonment, Bangladesh from January, 2002 and December, 2003 were studied...
July 2017: Mymensingh Medical Journal: MMJ
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