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https://www.readbyqxmd.com/read/28221189/a-retrospective-analysis-of-the-efficacy-of-pembrolizumab-in-melanoma-patients-with-brain-metastasis
#1
Ibiayi Dagogo-Jack, Michael Lanfranchi, Justin F Gainor, Anita Giobbie-Hurder, Donald P Lawrence, Alice T Shaw, Ryan J Sullivan
A total of 50% of patients with melanoma will develop brain metastasis (BM). Pembrolizumab was approved for treatment of metastatic melanoma on the basis of significant systemic antitumor activity. Because of low enrollment of patients with BM in pembrolizumab trials, efficacy against melanoma BM remains unknown. We reviewed records of 89 consecutive patients with melanoma treated with pembrolizumab at our institution between May 1, 2014 and October 31, 2015 to determine the time to progression. Thirty-six (40%) patients had BM before pembrolizumab...
February 17, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28114542/wearable-technology-and-long-term-weight-loss
#2
LETTER
Corrine I Voils, Ryan J Shaw
No abstract text is available yet for this article.
17, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28104455/a-novel-role-for-endothelial-tetrahydrobiopterin-in-mitochondrial-redox-balance
#3
Jade Bailey, Andrew Shaw, Roman Fischer, Brent J Ryan, Benedikt M Kessler, James McCullagh, Richard Wade-Martins, Keith M Channon, Mark J Crabtree
The redox co-factor tetrahydrobiopterin (BH4) regulates nitric oxide (NO) and reactive oxygen species (ROS) production by endothelial NOS (eNOS) and is an important redox-dependent signalling molecule in the endothelium. Loss of endothelial BH4 is observed in cardiovascular disease (CVD) states and results in decreased NO and increased superoxide (O2(-)) generation via eNOS uncoupling. Genetic mouse models of augmented endothelial BH4 synthesis have shown proof of concept that endothelial BH4 can alter CVD pathogenesis...
January 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28093637/exploring-differences-in-adverse-symptom-event-grading-thresholds-between-clinicians-and-patients-in-the-clinical-trial-setting
#4
Thomas M Atkinson, Lauren J Rogak, Narre Heon, Sean J Ryan, Mary Shaw, Liora P Stark, Antonia V Bennett, Ethan Basch, Yuelin Li
PURPOSE: Symptomatic adverse event (AE) monitoring is essential in cancer clinical trials to assess patient safety, as well as inform decisions related to treatment and continued trial participation. As prior research has demonstrated that conventional concordance metrics (e.g., intraclass correlation) may not capture nuanced aspects of the association between clinician and patient-graded AEs, we aimed to characterize differences in AE grading thresholds between doctors (MDs), registered nurses (RNs), and patients using the Bayesian Graded Item Response Model (GRM)...
January 16, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28067909/smchd1-mutations-associated-with-a-rare-muscular-dystrophy-can-also-cause-isolated-arhinia-and-bosma-arhinia-microphthalmia-syndrome
#5
Natalie D Shaw, Harrison Brand, Zachary A Kupchinsky, Hemant Bengani, Lacey Plummer, Takako I Jones, Serkan Erdin, Kathleen A Williamson, Joe Rainger, Alexei Stortchevoi, Kaitlin Samocha, Benjamin B Currall, Donncha S Dunican, Ryan L Collins, Jason R Willer, Angela Lek, Monkol Lek, Malik Nassan, Shahrin Pereira, Tammy Kammin, Diane Lucente, Alexandra Silva, Catarina M Seabra, Colby Chiang, Yu An, Morad Ansari, Jacqueline K Rainger, Shelagh Joss, Jill Clayton Smith, Margaret F Lippincott, Sylvia S Singh, Nirav Patel, Jenny W Jing, Jennifer R Law, Nalton Ferraro, Alain Verloes, Anita Rauch, Katharina Steindl, Markus Zweier, Ianina Scheer, Daisuke Sato, Nobuhiko Okamoto, Christina Jacobsen, Jeanie Tryggestad, Steven Chernausek, Lisa A Schimmenti, Benjamin Brasseur, Claudia Cesaretti, Jose E García-Ortiz, Tatiana Pineda Buitrago, Orlando Perez Silva, Jodi D Hoffman, Wolfgang Mühlbauer, Klaus W Ruprecht, Bart L Loeys, Masato Shino, Angela M Kaindl, Chie-Hee Cho, Cynthia C Morton, Richard R Meehan, Veronica van Heyningen, Eric C Liao, Ravikumar Balasubramanian, Janet E Hall, Stephanie B Seminara, Daniel Macarthur, Steven A Moore, Koh-Ichiro Yoshiura, James F Gusella, Joseph A Marsh, John M Graham, Angela E Lin, Nicholas Katsanis, Peter L Jones, William F Crowley, Erica E Davis, David R FitzPatrick, Michael E Talkowski
Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia revealed that 84% of probands harbor a missense mutation localized to a constrained region of SMCHD1 encompassing the ATPase domain. SMCHD1 mutations cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) via a trans-acting loss-of-function epigenetic mechanism. We discovered shared mutations and comparable DNA hypomethylation patterning between these distinct disorders...
February 2017: Nature Genetics
https://www.readbyqxmd.com/read/27935283/a-single-deoxynucleoside-kinase-variant-from-drosophila-melanogaster-synthesizes-monophosphates-of-nucleosides-that-are-components-of-an-expanded-genetic-system
#6
Mariko F Matsuura, Christian B Winiger, Ryan W Shaw, Myong-Jung Kim, Myong-Sang Kim, Ashley B Daugherty, Fei Chen, Patricia Moussatche, Jennifer D Moses, Stefan Lutz, Steven A Benner
Deoxynucleoside kinase from D. melanogaster (DmdNK) has broad specificity; although it catalyzes the phosphorylation of natural pyrimidine more efficiently than natural purine nucleosides, it accepts all four 2'-deoxynucleosides and many analogues, using ATP as a phosphate donor to give the corresponding deoxynucleoside monophosphates. Here, we show that replacing a single amino acid (glutamine 81 by glutamate) in DmdNK creates a variant that also catalyzes the phosphorylation of nucleosides that form part of an artificially expanded genetic information system (AEGIS)...
December 9, 2016: ACS Synthetic Biology
https://www.readbyqxmd.com/read/27927494/increasing-rates-of-surgical-management-of-multilevel-spinal-curvature-in-elderly-patients
#7
David C Sing, Ryan Khanna, Jeremy D Shaw, Lionel N Metz, Shane Burch, Sigurd H Berven
STUDY DESIGN: Retrospective analysis of Nationwide Inpatient Sample (NIS) database. OBJECTIVE: To analyze trends in utilization and hospital charges for multilevel spinal curvature surgery in patients over 60 from 2004 to 2011. SUMMARY OF BACKGROUND DATA: Multilevel spinal curvature has been increasingly recognized as a major source of morbidity in patients over sixty years of age. The economic burden of non-operative management for spinal curvature is elusive and likely underestimated...
September 2016: Spine Deformity
https://www.readbyqxmd.com/read/27892900/integrating-telepresence-robots-into-nursing-simulation
#8
Alexandra Rudolph, Jacqueline Vaughn, Nancy Crego, Remi Hueckel, Michele Kuszajewski, Margory Molloy, Raymond Brisson, Ryan J Shaw
This article provides an overview of the use of telepresence robots in clinical practice and describes an evaluation of an educational project in which distance-based nurse practitioner students used telepresence robots in clinical simulations with on-campus Accelerated Bachelor of Science in Nursing students. The results of this project suggest that the incorporation of telepresence in simulation is an effective method to promote engagement, satisfaction, and self-confidence in learning.
March 2017: Nurse Educator
https://www.readbyqxmd.com/read/27731862/feasibility-of-augmented-reality-in-clinical-simulations-using-google-glass-with-manikins
#9
Basil Chaballout, Margory Molloy, Jacqueline Vaughn, Raymond Brisson Iii, Ryan Shaw
BACKGROUND: Studies show that students who use fidelity-based simulation technology perform better and have higher retention rates than peers who learn in traditional paper-based training. Augmented reality is increasingly being used as a teaching and learning tool in a continual effort to make simulations more realistic for students. OBJECTIVE: The aim of this project was to assess the feasibility and acceptability of using augmented reality via Google Glass during clinical simulation scenarios for training health science students...
March 7, 2016: JMIR Medical Education
https://www.readbyqxmd.com/read/27701632/an-in-vitro-perfusion-system-to-enhance-outflow-studies-in-mouse-eyes
#10
Krishnakumar Kizhatil, Arthur Chlebowski, Nicholas G Tolman, Nelson F Freeburg, Margaret M Ryan, Nicholas N Shaw, Alexander D M Kokini, Jeffrey K Marchant, Simon W M John
Purpose: The molecular mechanisms controlling aqueous humor (AQH) outflow and IOP need much further definition. The mouse is a powerful system for characterizing the mechanistic basis of AQH outflow. To enhance outflow studies in mice, we developed a perfusion system that is based on human anterior chamber perfusion culture systems. Our mouse system permits previously impractical experiments. Methods: We engineered a computer-controlled, pump-based perfusion system with a platform for mounting whole dissected mouse eyes (minus lens and iris, ∼45% of drainage tissue is perfused)...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27668795/iron-oxide-nanoparticles-inhibit-tumour-growth-by-inducing-pro-inflammatory-macrophage-polarization-in-tumour-tissues
#11
Saeid Zanganeh, Gregor Hutter, Ryan Spitler, Olga Lenkov, Morteza Mahmoudi, Aubie Shaw, Jukka Sakari Pajarinen, Hossein Nejadnik, Stuart Goodman, Michael Moseley, Lisa Marie Coussens, Heike Elisabeth Daldrup-Link
Until now, the Food and Drug Administration (FDA)-approved iron supplement ferumoxytol and other iron oxide nanoparticles have been used for treating iron deficiency, as contrast agents for magnetic resonance imaging and as drug carriers. Here, we show an intrinsic therapeutic effect of ferumoxytol on the growth of early mammary cancers, and lung cancer metastases in liver and lungs. In vitro, adenocarcinoma cells co-incubated with ferumoxytol and macrophages showed increased caspase-3 activity. Macrophages exposed to ferumoxytol displayed increased mRNA associated with pro-inflammatory Th1-type responses...
November 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27663774/alternative-watson-crick-synthetic-genetic-systems
#12
Steven A Benner, Nilesh B Karalkar, Shuichi Hoshika, Roberto Laos, Ryan W Shaw, Mariko Matsuura, Diego Fajardo, Patricia Moussatche
In its "grand challenge" format in chemistry, "synthesis" as an activity sets out a goal that is substantially beyond current theoretical and technological capabilities. In pursuit of this goal, scientists are forced across uncharted territory, where they must answer unscripted questions and solve unscripted problems, creating new theories and new technologies in ways that would not be created by hypothesis-directed research. Thus, synthesis drives discovery and paradigm changes in ways that analysis cannot...
September 23, 2016: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/27648724/expanded-genetic-alphabets-managing-nucleotides-that-lack-tautomeric-protonated-or-deprotonated-versions-complementary-to-natural-nucleotides
#13
Christian B Winiger, Ryan W Shaw, Myong-Jung Kim, Jennifer D Moses, Mariko F Matsuura, Steven A Benner
2,4-Diaminopyrimidine (trivially K) and imidazo[1,2-a]-1,3,5-triazine-2(8H)-4(3H)-dione (trivially X) form a nucleobase pair with Watson-Crick geometry as part of an artificially expanded genetic information system (AEGIS). Neither K nor X can form a Watson-Crick pair with any natural nucleobase. Further, neither K nor X has an accessible tautomeric form or a protonated/deprotonated state that can form a Watson-Crick pair with any natural nucleobase. In vitro experiments show how DNA polymerase I from E. coli manages replication of DNA templates with one K:X pair, but fails with templates containing two adjacent K:X pairs...
October 7, 2016: ACS Synthetic Biology
https://www.readbyqxmd.com/read/27565168/the-impact-of-interventions-that-integrate-accelerometers-on-physical-activity-and-weight-loss-a-systematic-review
#14
Adam P Goode, Katherine S Hall, Bryan C Batch, Kim M Huffman, S Nicole Hastings, Kelli D Allen, Ryan J Shaw, Frances A Kanach, Jennifer R McDuffie, Andrzej S Kosinski, John W Williams, Jennifer M Gierisch
BACKGROUND: Regular physical activity is important for improving and maintaining health, but sedentary behavior is difficult to change. Providing objective, real-time feedback on physical activity with wearable motion-sensing technologies (activity monitors) may be a promising, scalable strategy to increase physical activity or decrease weight. PURPOSE: We synthesized the literature on the use of wearable activity monitors for improving physical activity and weight-related outcomes and evaluated moderating factors that may have an impact on effectiveness...
February 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27457548/trabecular-bone-structural-variation-throughout-the-human-lower-limb
#15
Jaap P P Saers, Yasmin Cazorla-Bak, Colin N Shaw, Jay T Stock, Timothy M Ryan
Trabecular bone is responsive to mechanical loading, and thus may be a useful tool for interpreting past behaviour from fossil morphology. However, the ability to meaningfully interpret variation in archaeological and hominin trabecular morphology depends on the extent to which trabecular bone properties are integrated throughout the postcranium or are locally variable in response to joint specific loading. We investigate both of these factors by comparing trabecular bone throughout the lower limb between a group of highly mobile foragers and two groups of sedentary agriculturalists...
August 2016: Journal of Human Evolution
https://www.readbyqxmd.com/read/27355033/effect-of-coronary-computed-tomography-angiography-disease-burden-on-the-incidence-of-recurrent-chest-pain
#16
Homayoun R Ahmadian, Dustin M Thomas, David J Shaw, Megan L Barnwell, Ronald L Jones, Ryan J McDonough, Ryan L Prentice, Charles K Lin, Ahmad M Slim
Introduction. The purpose of this study is to investigate chest pain evaluations after initial coronary computed tomography angiography (CCTA) based upon coronary artery disease (CAD) burden. Methods. CCTA results of 1,518 patients were grouped based on the CCTA results into no CAD, nonobstructive CAD (<50% maximal diameter stenosis), or obstructive CAD (≥50% stenosis). Chest pain evaluation after initial CCTA and rates of major adverse cardiovascular events (MACE) defined as the incidence of all-cause mortality, nonfatal MI, ischemic stroke, and late revascularization (>90 days following CCTA) were evaluated...
2014: International Scholarly Research Notices
https://www.readbyqxmd.com/read/27347689/polymerase-interactions-with-wobble-mismatches-in-synthetic-genetic-systems-and-their-evolutionary-implications
#17
Christian B Winiger, Myong-Jung Kim, Shuichi Hoshika, Ryan W Shaw, Jennifer D Moses, Mariko F Matsuura, Dietlind L Gerloff, Steven A Benner
In addition to completing the Watson-Crick nucleobase matching "concept" (big pairs with small, hydrogen bond donors pair with hydrogen bond acceptors), artificially expanded genetic information systems (AEGIS) also challenge DNA polymerases with a complete set of mismatches, including wobble mismatches. Here, we explore wobble mismatches with AEGIS with DNA polymerase 1 from Escherichia coli. Remarkably, we find that the polymerase tolerates an AEGIS:standard wobble that has the same geometry as the G:T wobble that polymerases have evolved to exclude but excludes a wobble geometry that polymerases have never encountered in natural history...
July 19, 2016: Biochemistry
https://www.readbyqxmd.com/read/27332446/an-innovative-use-of-telepresence-robots-for-educating-healthcare-professional
#18
Margie Molloy, Ryan J Shaw, Jackie Vaughn, Remi Hueckel
Telehealth enhances communication across distances, facilitates teamwork, and increases access to care, particularly in rural areas. As the use of telehealth technology assimilates into clinical practice, its integration is also needed in clinical curricula. Students participated in 2 pediatric scenarios in teams of 3 to 4 prelicensure nursing students, with one nurse practitioner student participating via a telepresence robot. Forty-eight prelicensure and 5 nurse practitioner students completed surveys following the clinical simulations...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27332339/the-future-of-informatics-in-aged-care-an-international-perspective
#19
Gregory L Alexander, Patti Abbott, Mariann Fossum, Ryan J Shaw, Ping Yu, Mary M Alexander
The panel will share global technology research initiatives in aged care. Panel objectives: 1) Describe international informatics research initiatives by experts addressing health needs of the aged, 2) Contrast health technologies used to manage aging patients, and 3) Explain challenges and opportunities to improve healthcare informatics for aging patients. Intended audience: researchers, consumers, practitioners, vendors, care providers, and policy makers with interests in aged care technology design, development, implementation and management...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27313661/strain-and-bioprocess-improvement-of-a-thermophilic-anaerobe-for-the-production-of-ethanol-from-wood
#20
Christopher D Herring, William R Kenealy, A Joe Shaw, Sean F Covalla, Daniel G Olson, Jiayi Zhang, W Ryan Sillers, Vasiliki Tsakraklides, John S Bardsley, Stephen R Rogers, Philip G Thorne, Jessica P Johnson, Abigail Foster, Indraneel D Shikhare, Dawn M Klingeman, Steven D Brown, Brian H Davison, Lee R Lynd, David A Hogsett
BACKGROUND: The thermophilic, anaerobic bacterium Thermoanaerobacterium saccharolyticum digests hemicellulose and utilizes the major sugars present in biomass. It was previously engineered to produce ethanol at yields equivalent to yeast. While saccharolytic anaerobes have been long studied as potential biomass-fermenting organisms, development efforts for commercial ethanol production have not been reported. RESULTS: Here, we describe the highest ethanol titers achieved from T...
2016: Biotechnology for Biofuels
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