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https://www.readbyqxmd.com/read/29237794/recommendations-of-the-global-multiple-system-atrophy-research-roadmap-meeting
#1
REVIEW
Ryan R Walsh, Florian Krismer, Wendy R Galpern, Gregor K Wenning, Phillip A Low, Glenda Halliday, Walter J Koroshetz, Janice Holton, Niall P Quinn, Olivier Rascol, Leslie M Shaw, David Eidelberg, Pam Bower, Jeffrey L Cummings, Victor Abler, Judy Biedenharn, Gal Bitan, David J Brooks, Patrik Brundin, Hubert Fernandez, Philip Fortier, Roy Freeman, Thomas Gasser, Art Hewitt, Günter U Höglinger, Matt J Huentelman, Poul H Jensen, Andreas Jeromin, Un Jung Kang, Horacio Kaufmann, Lawrence Kellerman, Vikram Khurana, Thomas Klockgether, Woojin Scott Kim, Carol Langer, Peter LeWitt, Eliezer Masliah, Wassilios Meissner, Ronald Melki, Susanne Ostrowitzki, Steven Piantadosi, Werner Poewe, David Robertson, Cyndi Roemer, Dale Schenk, Michael Schlossmacher, Jeremy D Schmahmann, Klaus Seppi, Lily Shih, Andrew Siderowf, Glenn T Stebbins, Nadia Stefanova, Shoji Tsuji, Sharon Sutton, Jing Zhang
Multiple system atrophy (MSA) is a rare neurodegenerative disorder with substantial knowledge gaps despite recent gains in basic and clinical research. In order to make further advances, concerted international collaboration is vital. In 2014, an international meeting involving leaders in the field and MSA advocacy groups was convened in Las Vegas, Nevada, to identify critical research areas where consensus and progress was needed to improve understanding, diagnosis, and treatment of the disease. Eight topic areas were defined: pathogenesis, preclinical modeling, target identification, endophenotyping, clinical measures, imaging biomarkers, nonimaging biomarkers, treatments/trial designs, and patient advocacy...
December 13, 2017: Neurology
https://www.readbyqxmd.com/read/29233916/aging-impairs-both-primary-and-secondary-rig-i-signaling-for-interferon-induction-in-human-monocytes
#2
Ryan D Molony, Jenny T Nguyen, Yong Kong, Ruth R Montgomery, Albert C Shaw, Akiko Iwasaki
Adults older than 65 account for most of the deaths caused by respiratory influenza A virus (IAV) infections, but the underlying mechanisms for this susceptibility are poorly understood. IAV RNA is detected by the cytosolic sensor retinoic acid-inducible gene I (RIG-I), which induces the production of type I interferons (IFNs) that curtail the spread of the virus and promote the elimination of infected cells. We have previously identified a marked defect in the IAV-inducible secretion of type I IFNs, but not proinflammatory cytokines, in monocytes from older (>65 years) healthy human donors...
December 12, 2017: Science Signaling
https://www.readbyqxmd.com/read/29206318/automated-quality-assessment-of-structural-magnetic-resonance-images-in-children-comparison-with-visual-inspection-and-surface-based-reconstruction
#3
Tonya White, Philip R Jansen, Ryan L Muetzel, Gustavo Sudre, Hanan El Marroun, Henning Tiemeier, Anqi Qiu, Philip Shaw, Andrew M Michael, Frank C Verhulst
Motion-related artifacts are one of the major challenges associated with pediatric neuroimaging. Recent studies have shown a relationship between visual quality ratings of T1 images and cortical reconstruction measures. Automated algorithms offer more precision in quantifying movement-related artifacts compared to visual inspection. Thus, the goal of this study was to test three different automated quality assessment algorithms for structural MRI scans. The three algorithms included a Fourier-, integral-, and a gradient-based approach which were run on raw T1 -weighted imaging data collected from four different scanners...
December 5, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29171321/changes-in-medical-student-implicit-attitudes-following-a-health-equity-curricular-intervention
#4
Katie F Leslie, Susan Sawning, M Ann Shaw, Leslee J Martin, Ryan C Simpson, Jennifer E Stephens, V Faye Jones
PURPOSE: This study assessed the: (1) effect of an LGBTQI + health equity curriculum (eQuality) on implicit attitudes among first (M1) and second year (M2) medical students and (2) utility of dedicated time to explore implicit bias. METHOD: Implicit biases were assessed at baseline using implicit association tests (IAT) for all M2s and a random sample of first years (M1A). These students were then debriefed on strategies to mitigate bias. Following eQuality, all M1 and M2s completed post-intervention IATs...
November 24, 2017: Medical Teacher
https://www.readbyqxmd.com/read/29134039/monogenea-of-fishes-from-the-lagoon-flats-of-palmyra-atoll-in-the-central-pacific
#5
Víctor Manuel Vidal-Martínez, Lilia Catherinne Soler-Jiménez, Ma Leopoldina Aguirre-Macedo, John Mclaughlin, Alejandra G Jaramillo, Jenny C Shaw, Anna James, Ryan F Hechinger, Armand M Kuris, Kevin D Lafferty
A survey of the monogeneans of fishes from the lagoon flats of Palmyra Atoll detected 16 species already reported from the Indo-West Pacific faunal region. A total of 653 individual fish from 44 species were collected from the sand flats bordering the lagoon of the atoll. Eighteen species of fish were infected with monogeneans. The monogenean species recovered were: Benedenia hawaiiensis on Acanthurus xanthopterus, Chaetodon auriga, Chaetodon lunula, Mulloidichthys flavolineatus, Pseudobalistes flavimarginatus and Rhinecanthus aculeatus; Ancyrocephalus ornatus on Arothron hispidus; Euryhaliotrema annulocirrus on Chaetodon auriga and Chaetodon lunula; Euryhaliotrema chrysotaeniae on Lutjanus fulvus; Euryhaliotrema grandis on Chaetodon auriga and Chaetodon lunula; Haliotrema acanthuri on Acanthurus triostegus; Haliotrema aurigae on Chaetodon auriga and Chaetodon lunula; Haliotrema dempsteri on Acanthurus xanthopterus; Haliotrema minutospirale on Mulloidichthys flavolineatus; Haliotrematoides patellacirrus on Lutjanus monostigma; Neohaliotrema bombini on Abudefduf septemfasciatus and Abudefduf sordidus; Acleotrema girellae and Acleotrema parastromatei on Kyphosus cinerascens; Cemocotylella elongata on Caranx ignobilis, Caranx melampygus and Caranx papuensis; Metamicrocotyla macracantha on Crenimugil crenilabris; and Pseudopterinotrema albulae on Albula glossodonta...
2017: ZooKeys
https://www.readbyqxmd.com/read/29055969/asymmetry-in-the-cortical-and-trabecular-bone-of-the-human-humerus-during-development
#6
Bernadette Perchalski, Arielle Placke, Simone M Sukhdeo, Colin N Shaw, James H Gosman, David A Raichlen, Timothy M Ryan
Many studies have noted that the bones of the human upper limb display bilateral asymmetry, commonly linking this asymmetry in external and internal morphology to handedness and lateralization. Few studies, however, have attempted to track asymmetry throughout ontogeny. This study assesses the ontogenetic development of cortical and trabecular bone asymmetry in the humerus. We predict that directional asymmetry in structural properties will emerge in concert with hand preference and increased activity levels during the juvenile period...
October 22, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29034821/abstracts-and-workshops-7th-national-spinal-cord-injury-conference-november-9-11-2017-fallsview-casino-resort-niagara-falls-ontario-canada
#7
Mir Hatef Shojaei, Mohammad Alavinia, B Catharine Craven, Christiana L Cheng, Tova Plashkes, Tian Shen, Nader Fallah, Suzanne Humphreys, Colleen O'Connell, Angelo Gary Linassi, Chester Ho, Christine Short, Karen Ethans, Rebecca Charbonneau, Jerome Paquet, Vanessa K Noonan, Julio C Furlan, Michael G Fehlings, B Catharine Craven, Jirapat Likitlersuang, Elizabeth Sumitro, Sukhvinder Kalsi-Ryan, José Zariffa, Dalton Wolfe, Stephanie Cornell, Julie Gagliardi, Stephanie Marrocco, Carly S Rivers, Nader Nader Fallah, Vanessa K Noonan, David Whitehurst, Carolyn Schwartz, Joel Finkelstein, B Catharine Craven, Karen Ethans, Colleen O'Connell, Catherine Truchon, Chester Ho, A Gary Linassi, Christine Short, Eve Tsai, Brian Drew, Henry Ahn, Marcel F Dvorak, Jérôme Paquet, Michael G Fehlings, Luc Noreau, Katie Lenz, K Alysse Bailey, David Allison, David Ditor, Justine Baron, Jennifer Tomasone, Dorothyann Curran, Toba Miller, Jeremy Grimshaw, Bastien Moineau, Milad Alizadeh-Meghrazi, Gabriel Stefan, Kei Masani, Milos R Popovic, Elizabeth Sumitro, Jirapat Likitlersuang, Sukhvinder Kalsi-Ryan, José Zariffa, Martha G Garcia-Garcia, Cesar Marquez-Chin, Milos R Popovic, Julio C Furlan, Sivakumar Gulasingam, B Catharine Craven, Julio C Furlan, Sivakumar Gulasingam, B Catharine Craven, Alia Khan, Clara Pujol, Mark Laylor, Nikola Unic, Maureen Pakosh, Kristin Musselman, Louise M Brisbois, B Catharine Craven, Mary C Verrier, Maryleen K Jones, Roberta O'Shea, Sakina Valika, Kaila Holtz, Elena Szefer, Vanessa Noonan, Brian Kwon, Patricia Mills, Cynthia Morin, Anne Harris, Christiana Cheng, Arlene Aspinall, Tova Plashkes, Vanessa K Noonan, Katherine Chan, Mary C Verrier, B Catharine Craven, Chris Alappat, Heather M Flett, Julio C Furlan, Kristin E Musselman, James Milligan, Loretta M Hillier, Craig Bauman, Lindsay Donaldson, Joseph Lee, James Milligan, Joseph Lee, Loretta M Hillier, Karen Slonim, Dalton Wolfe, Lindsay Sleeth, Samantha Jeske, Anna Kras-Dupuis, Stephanie Marrocco, Samantha McRae, Heather Flett, Jennifer Mokry, Joanne Zee, Mark Bayley, Jean-Francois Lemay, Audrey Roy, H Dany Gagnon, Maryleen K Jones, Roberta O'Shea, Renee Theiss, Heather Flett, Kristina Guy, Gillian Johnston, Melanie Kokotow, Sandra Mills, Jennifer Mokry, Patricia Bain, Carol Scovil, Pamela Houghton, Deena Lala, Lyndsay Orr, Paul Holyoke, Dalton Wolfe, Lyndsay Orr, Jillian Brooke, Paul Holyoke, Deena Lala, Pamela Houghton, Kathleen A Martin Ginis, Robert B Shaw, Matthew J Stork, Christopher B McBride, Julio C Furlan, B Catharine Craven, Lora Giangregorio, Sander Hitzig, Naaz Kapadia, Milos R Popovic, Vera Zivanovic, Taufik Valiante, Milos R Popovic, Eleni Patsakos, Louise Brisbois, Farnoosh Farahani, Anita Kaiser, B Catharine Craven, Eleni Patsakos, Anita Kaiser, Louise Brisbois, Farnoosh Farahani, B Catharine Craven, Ben Mortenson, Megan MacGillivray, Sadeghi Mahsa, Jared Adams, Bonita Sawatzky, Patricia Mills, Kelly Arbour-Nicitopoulos, Rebecca Bassett-Gunter, Jennifer Leo, Ritu Sharma, Amy Latimer-Cheung, Timothy Olds, Kathleen Martin Ginis, Marnie Graco, Susan Cross, Chinnaya Thiyagarajan, Shirin Shafazand, Najib Ayas, Rachel Schembri, Lauren Booker, Carmel Nicholls, Patricia Burns, Mark Nash, Sally Green, David J Berlowitz, Samantha Taran, Meredith Rocchi, Kathleen A Martin Ginis, Shane N Sweet, Jeffrey G Caron, Shane N Sweet, Meredith A Rocchi, Walter Zelaya, Shane N Sweet, Austin J Bergquist, Mikael F Del Castillo-Valenzuela, Milos R Popovic, Kei Masani, Karen Ethans, Alan Casey, Micheal Namaka, Dimitri Krassiokov-Enns, Cesar Marquez-Chin, Aaron Marquis, Naaz Desai, Vera Zivanovic, Debbie Hebert, Milos R Popovic, Julio C Furlan, B Catharine Craven, Jonathan McLeod, Audrey Hicks, Cindy Gauthier, Jasmine Arel, Rachel Brosseau, Audrey L Hicks, Dany H Gagnon, Nasrin Nejatbakhsh, Anita Kaiser, Sander L Hitzig, Shauna Cappe, Colleen McGillivray, Hardeep Singh, Jaya Sam, Heather Flett, B Catharine Craven, Mary Verrier, Kristin Musselman, Ryan G L Koh, Purbasha Garai, José Zariffa, Janelle Unger, Alison R Oates, Tarun Arora, Kristin Musselman, Bondi Moshe, Burns Anthony, Sivakumar Gulasingam, B Catharine Craven, Emilie Michalovic, Heather L Gainforth, Justine Baron, Ian D Graham, Shane N Sweet, Brian Chan, B Catharine Craven, Walter Wodchis, Suzanne Cadarette, Murray Krahn, Nicole Mittmann, Keryn Chemtob, Meredith A Rocchi, Kelly Arbour-Nicitopoulos, Dahlia Kairy, Shane N Sweet, Parisa Sabetian, Ryan G L Koh, José Zariffa, Paul Yoo, Stephanie N Iwasa, Robart Babona-Pilipos, Patrick Schneider, Prashanth Velayudhan, Umalkhair Ahmed, Milos R Popovic, Cindi M Morshead, Jaeeun Yoo, Masahiro Shinya, Matija Milosevic, Kei Masani, Sharon Gabison, Sunita Mathur, Ethne Nussbaum, Milos Popovic, Mary C Verrier, Kristin Musselman, Jean-François Lemay, Shane McCullum, Kristina Guy, Kristen Walden, Jose Zariffa, Sukhvinder Kalsi-Ryan, Milad Alizadeh-Meghrazi, Joseph Lee, James Milligan, Matt Smith, Peter Athanasopoulos, Tara Jeji, Jennifer Howcroft, Jeremy Howcroft, Andrea Townson, Rhonda Willms, Tova Plashkes, Sandra Mills, Heather Flett, Carol Scovil, Filomena Mazzella, Helen Morris, Anellina Ventre, Eldon Loh, Stacey Guy, John Kramer, Tara Jeji, Nancy Xia, Swati Mehta, Kathleen A Martin Ginis, Christopher B McBride, Robert B Shaw, Christopher West, Karen Ethans, Colleen O'Connell, Susan Charlifue, Dany H Gagnon, Manuel Jose Escalona Castillo, Martin Vermette, Lívia Pinheiro Carvalho, Antony Karelis, Dahlia Kairy, Mylène Aubertin-Leheudre, Cyril Duclos, Pamela E Houghton, Lyndsay Orr, Paul Holyoke, Anna Kras-Dupuis, Dalton Wolfe, Barry Munro, Michelle Sweeny, B Catharine Craven, Heather Flett, Sander Hitzig, Farnoosh Farahani, S Mohammad Alavinia, Maryam Omidvar, Mark Bayley, Shane N Sweet, Julie Gassaway, Rob Shaw, Minna Hong, Sarah Everhart-Skeels, Bethlyn Houlihan, Anthony Burns, Gerald Bilsky, Indira Lanig, Marnie Graco, Susan Cross, Chinnaya Thiyagarajan, Shirin Shafazand, Najib Ayas, Rachel Schembri, Lauren Booker, Carmel Nicholls, Patricia Burns, Mark Nash, Sally Green, David Berlowitz, Julio C Furlan, Sukhvinder Kalsi-Ryan
No abstract text is available yet for this article.
November 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28947949/correction-to-discovery-of-fevipiprant-nvp-qaw039-a-potent-and-selective-dp2-receptor-antagonist-for-treatment-of-asthma
#8
David A Sandham, Lucy Barker, Lyndon Brown, Zarin Brown, David Budd, Steven J Charlton, Devnandan Chatterjee, Brian Cox, Gerald Dubois, Nicholas Duggan, Edward Hall, Julia Hatto, Catherine Leblanc, Janet Maas, Jodie Manini, Rachael Profit, Darren Riddy, Catherine Ritchie, Bindi Sohal, Duncan Shaw, Rowan Stringer, David A Sykes, Matthew Thomas, Katharine L Turner, Simon J Watson, Ryan West, Elisabeth Willard, Gareth Williams, Jennifer Willis
[This corrects the article DOI: 10.1021/acsmedchemlett.7b00157.].
September 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28928340/a-first-step-in-addressing-medical-education-curriculum-gaps-in-lesbian-gay-bisexual-and-transgender-related-content-the-university-of-louisville-lesbian-gay-bisexual-and-transgender-health-certificate-program
#9
Susan Sawning, Stacie Steinbock, Rachel Croley, Ryan Combs, Ann Shaw, Toni Ganzel
BACKGROUND: Individuals who are lesbian, gay, bisexual, transgender (LGBT), gender nonconforming, and/or born with differences of sex development have specific health needs and significant health disparities exacerbated by a lack of training among health professionals. The University of Louisville LGBT Health Certificate Program used an interdisciplinary approach to increase training, potentially enabling future physicians to provide quality healthcare to LGBT patients. METHODS: A pretest-post-test design was used to investigate medical students' (n = 39) attitude and knowledge outcomes after program participation...
May 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28887402/detection-of-long-repeat-expansions-from-pcr-free-whole-genome-sequence-data
#10
Egor Dolzhenko, Joke J F A van Vugt, Richard J Shaw, Mitchell A Bekritsky, Marka van Blitterswijk, Giuseppe Narzisi, Subramanian S Ajay, Vani Rajan, Bryan R Lajoie, Nathan H Johnson, Zoya Kingsbury, Sean J Humphray, Raymond D Schellevis, William J Brands, Matt Baker, Rosa Rademakers, Maarten Kooyman, Gijs H P Tazelaar, Michael A van Es, Russell McLaughlin, William Sproviero, Aleksey Shatunov, Ashley Jones, Ahmad Al Khleifat, Alan Pittman, Sarah Morgan, Orla Hardiman, Ammar Al-Chalabi, Chris Shaw, Bradley Smith, Edmund J Neo, Karen Morrison, Pamela J Shaw, Catherine Reeves, Lara Winterkorn, Nancy S Wexler, David E Housman, Christopher W Ng, Alina L Li, Ryan J Taft, Leonard H van den Berg, David R Bentley, Jan H Veldink, Michael A Eberle
Identifying large expansions of short tandem repeats (STRs), such as those that cause amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-genome sequencing (WGS) data. A solution to this problem is an important step toward integrating WGS into precision medicine. We developed a software tool called ExpansionHunter that, using PCR-free WGS short-read data, can genotype repeats at the locus of interest, even if the expanded repeat is larger than the read length. We applied our algorithm to WGS data from 3001 ALS patients who have been tested for the presence of the C9orf72 repeat expansion with repeat-primed PCR (RP-PCR)...
November 2017: Genome Research
https://www.readbyqxmd.com/read/28868735/micronuclei-and-other-erythrocyte-nuclear-abnormalities-in-fishes-from-the-great-lakes-basin-usa
#11
Ryan P Braham, Vicki S Blazer, Cassidy H Shaw, Patricia M Mazik
Biological markers (biomarkers) sensitive to genotoxic and mutagenic contamination in fishes are widely used to identify exposure effects in aquatic environments. The micronucleus assay was incorporated into a suite of indicators to assess exposure to genotoxic and mutagenic contamination at five Great Lakes Areas of Concern (AOCs), as well as one non-AOC (reference) site. The assay allowed enumeration of micronuclei as well as other nuclear abnormalities for both site and species comparisons. Erythrocyte abnormality data was also compared to skin and liver tumor prevalence and hepatic transcript abundance...
October 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28867495/healthcare-policy-statement-on-the-utility-of-coronary-computed-tomography-for-evaluation-of-cardiovascular-conditions-and-preventive-healthcare-from-the-health-policy-working-group-of-the-society-of-cardiovascular-computed-tomography
#12
Ahmad M Slim, Scott Jerome, Ron Blankstein, Wm Guy Weigold, Amit R Patel, Dinesh K Kalra, Ryan Miller, Kelley Branch, Mark G Rabbat, Harvey Hecht, Edward D Nicol, Todd C Villines, Leslee J Shaw
The rising cost of healthcare is prompting numerous policy and advocacy discussions regarding strategies for constraining growth and creating a more efficient and effective healthcare system. Cardiovascular imaging is central to the care of patients at risk of, and living with, heart disease. Estimates are that utilization of cardiovascular imaging exceeds 20 million studies per year. The Society of Cardiovascular CT (SCCT), alongside Rush University Medical Center, and in collaboration with government agencies, regional payers, and industry healthcare experts met in November 2016 in Chicago, IL to evaluate obstacles and hurdles facing the cardiovascular imaging community and how they can contribute to efficacy while maintaining or even improving outcomes and quality...
August 31, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28817944/tracking-brain-development-and-dimensional-psychiatric-symptoms-in-children-a-longitudinal-population-based-neuroimaging-study
#13
Ryan L Muetzel, Laura M E Blanken, Jan van der Ende, Hanan El Marroun, Philip Shaw, Gustavo Sudre, Aad van der Lugt, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier, Tonya White
OBJECTIVE: Psychiatric symptomatology during childhood predicts persistent mental illness later in life. While neuroimaging methodologies are routinely applied cross-sectionally to the study of child and adolescent psychopathology, the nature of the relationship between childhood symptoms and the underlying neurodevelopmental processes remains unclear. The authors used a prospective population-based cohort to delineate the longitudinal relationship between childhood psychiatric problems and brain development...
August 18, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28714976/rare-coding-variants-in-plcg2-abi3-and-trem2-implicate-microglial-mediated-innate-immunity-in-alzheimer-s-disease
#14
Rebecca Sims, Sven J van der Lee, Adam C Naj, Céline Bellenguez, Nandini Badarinarayan, Johanna Jakobsdottir, Brian W Kunkle, Anne Boland, Rachel Raybould, Joshua C Bis, Eden R Martin, Benjamin Grenier-Boley, Stefanie Heilmann-Heimbach, Vincent Chouraki, Amanda B Kuzma, Kristel Sleegers, Maria Vronskaya, Agustin Ruiz, Robert R Graham, Robert Olaso, Per Hoffmann, Megan L Grove, Badri N Vardarajan, Mikko Hiltunen, Markus M Nöthen, Charles C White, Kara L Hamilton-Nelson, Jacques Epelbaum, Wolfgang Maier, Seung-Hoan Choi, Gary W Beecham, Cécile Dulary, Stefan Herms, Albert V Smith, Cory C Funk, Céline Derbois, Andreas J Forstner, Shahzad Ahmad, Hongdong Li, Delphine Bacq, Denise Harold, Claudia L Satizabal, Otto Valladares, Alessio Squassina, Rhodri Thomas, Jennifer A Brody, Liming Qu, Pascual Sánchez-Juan, Taniesha Morgan, Frank J Wolters, Yi Zhao, Florentino Sanchez Garcia, Nicola Denning, Myriam Fornage, John Malamon, Maria Candida Deniz Naranjo, Elisa Majounie, Thomas H Mosley, Beth Dombroski, David Wallon, Michelle K Lupton, Josée Dupuis, Patrice Whitehead, Laura Fratiglioni, Christopher Medway, Xueqiu Jian, Shubhabrata Mukherjee, Lina Keller, Kristelle Brown, Honghuang Lin, Laura B Cantwell, Francesco Panza, Bernadette McGuinness, Sonia Moreno-Grau, Jeremy D Burgess, Vincenzo Solfrizzi, Petra Proitsi, Hieab H Adams, Mariet Allen, Davide Seripa, Pau Pastor, L Adrienne Cupples, Nathan D Price, Didier Hannequin, Ana Frank-García, Daniel Levy, Paramita Chakrabarty, Paolo Caffarra, Ina Giegling, Alexa S Beiser, Vilmantas Giedraitis, Harald Hampel, Melissa E Garcia, Xue Wang, Lars Lannfelt, Patrizia Mecocci, Gudny Eiriksdottir, Paul K Crane, Florence Pasquier, Virginia Boccardi, Isabel Henández, Robert C Barber, Martin Scherer, Lluis Tarraga, Perrie M Adams, Markus Leber, Yuning Chen, Marilyn S Albert, Steffi Riedel-Heller, Valur Emilsson, Duane Beekly, Anne Braae, Reinhold Schmidt, Deborah Blacker, Carlo Masullo, Helena Schmidt, Rachelle S Doody, Gianfranco Spalletta, W T Longstreth Jr, Thomas J Fairchild, Paola Bossù, Oscar L Lopez, Matthew P Frosch, Eleonora Sacchinelli, Bernardino Ghetti, Qiong Yang, Ryan M Huebinger, Frank Jessen, Shuo Li, M Ilyas Kamboh, John Morris, Oscar Sotolongo-Grau, Mindy J Katz, Chris Corcoran, Melanie Dunstan, Amy Braddel, Charlene Thomas, Alun Meggy, Rachel Marshall, Amy Gerrish, Jade Chapman, Miquel Aguilar, Sarah Taylor, Matt Hill, Mònica Díez Fairén, Angela Hodges, Bruno Vellas, Hilkka Soininen, Iwona Kloszewska, Makrina Daniilidou, James Uphill, Yogen Patel, Joseph T Hughes, Jenny Lord, James Turton, Annette M Hartmann, Roberta Cecchetti, Chiara Fenoglio, Maria Serpente, Marina Arcaro, Carlo Caltagirone, Maria Donata Orfei, Antonio Ciaramella, Sabrina Pichler, Manuel Mayhaus, Wei Gu, Alberto Lleó, Juan Fortea, Rafael Blesa, Imelda S Barber, Keeley Brookes, Chiara Cupidi, Raffaele Giovanni Maletta, David Carrell, Sandro Sorbi, Susanne Moebus, Maria Urbano, Alberto Pilotto, Johannes Kornhuber, Paolo Bosco, Stephen Todd, David Craig, Janet Johnston, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Nick C Fox, John Hardy, Roger L Albin, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Clinton T Baldwin, Lisa L Barnes, Sandra Barral, Thomas G Beach, James T Becker, Eileen H Bigio, Thomas D Bird, Bradley F Boeve, James D Bowen, Adam Boxer, James R Burke, Jeffrey M Burns, Joseph D Buxbaum, Nigel J Cairns, Chuanhai Cao, Chris S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Steven L Carroll, Carolina Ceballos Diaz, Helena C Chui, David G Clark, David H Cribbs, Elizabeth A Crocco, Charles DeCarli, Malcolm Dick, Ranjan Duara, Denis A Evans, Kelley M Faber, Kenneth B Fallon, David W Fardo, Martin R Farlow, Steven Ferris, Tatiana M Foroud, Douglas R Galasko, Marla Gearing, Daniel H Geschwind, John R Gilbert, Neill R Graff-Radford, Robert C Green, John H Growdon, Ronald L Hamilton, Lindy E Harrell, Lawrence S Honig, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Gail P Jarvik, Erin Abner, Lee-Way Jin, Gyungah Jun, Anna Karydas, Jeffrey A Kaye, Ronald Kim, Neil W Kowall, Joel H Kramer, Frank M LaFerla, James J Lah, James B Leverenz, Allan I Levey, Ge Li, Andrew P Lieberman, Kathryn L Lunetta, Constantine G Lyketsos, Daniel C Marson, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, John C Morris, Jill R Murrell, Amanda J Myers, Sid O'Bryant, John M Olichney, Vernon S Pankratz, Joseph E Parisi, Henry L Paulson, William Perry, Elaine Peskind, Aimee Pierce, Wayne W Poon, Huntington Potter, Joseph F Quinn, Ashok Raj, Murray Raskind, Barry Reisberg, Christiane Reitz, John M Ringman, Erik D Roberson, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Mark A Sager, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Russell H Swerdlow, Rudolph E Tanzi, Tricia A Thornton-Wells, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Linda J Van Eldik, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Kirk C Wilhelmsen, Jennifer Williamson, Thomas S Wingo, Randall L Woltjer, Clinton B Wright, Chang-En Yu, Lei Yu, Fabienne Garzia, Feroze Golamaully, Gislain Septier, Sebastien Engelborghs, Rik Vandenberghe, Peter P De Deyn, Carmen Muñoz Fernadez, Yoland Aladro Benito, Hakan Thonberg, Charlotte Forsell, Lena Lilius, Anne Kinhult-Stählbom, Lena Kilander, RoseMarie Brundin, Letizia Concari, Seppo Helisalmi, Anne Maria Koivisto, Annakaisa Haapasalo, Vincent Dermecourt, Nathalie Fievet, Olivier Hanon, Carole Dufouil, Alexis Brice, Karen Ritchie, Bruno Dubois, Jayanadra J Himali, C Dirk Keene, JoAnn Tschanz, Annette L Fitzpatrick, Walter A Kukull, Maria Norton, Thor Aspelund, Eric B Larson, Ron Munger, Jerome I Rotter, Richard B Lipton, María J Bullido, Albert Hofman, Thomas J Montine, Eliecer Coto, Eric Boerwinkle, Ronald C Petersen, Victoria Alvarez, Fernando Rivadeneira, Eric M Reiman, Maura Gallo, Christopher J O'Donnell, Joan S Reisch, Amalia Cecilia Bruni, Donald R Royall, Martin Dichgans, Mary Sano, Daniela Galimberti, Peter St George-Hyslop, Elio Scarpini, Debby W Tsuang, Michelangelo Mancuso, Ubaldo Bonuccelli, Ashley R Winslow, Antonio Daniele, Chuang-Kuo Wu, Oliver Peters, Benedetta Nacmias, Matthias Riemenschneider, Reinhard Heun, Carol Brayne, David C Rubinsztein, Jose Bras, Rita Guerreiro, Ammar Al-Chalabi, Christopher E Shaw, John Collinge, David Mann, Magda Tsolaki, Jordi Clarimón, Rebecca Sussams, Simon Lovestone, Michael C O'Donovan, Michael J Owen, Timothy W Behrens, Simon Mead, Alison M Goate, Andre G Uitterlinden, Clive Holmes, Carlos Cruchaga, Martin Ingelsson, David A Bennett, John Powell, Todd E Golde, Caroline Graff, Philip L De Jager, Kevin Morgan, Nilufer Ertekin-Taner, Onofre Combarros, Bruce M Psaty, Peter Passmore, Steven G Younkin, Claudine Berr, Vilmundur Gudnason, Dan Rujescu, Dennis W Dickson, Jean-François Dartigues, Anita L DeStefano, Sara Ortega-Cubero, Hakon Hakonarson, Dominique Campion, Merce Boada, John Keoni Kauwe, Lindsay A Farrer, Christine Van Broeckhoven, M Arfan Ikram, Lesley Jones, Jonathan L Haines, Christophe Tzourio, Lenore J Launer, Valentina Escott-Price, Richard Mayeux, Jean-François Deleuze, Najaf Amin, Peter A Holmans, Margaret A Pericak-Vance, Philippe Amouyel, Cornelia M van Duijn, Alfredo Ramirez, Li-San Wang, Jean-Charles Lambert, Sudha Seshadri, Julie Williams, Gerard D Schellenberg
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10(-4)) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10(-8)) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p...
September 2017: Nature Genetics
https://www.readbyqxmd.com/read/28622927/evolution-of-the-hominin-knee-and-ankle
#15
Mélanie A Frelat, Colin N Shaw, Simone Sukhdeo, Jean-Jacques Hublin, Stefano Benazzi, Timothy M Ryan
The dispersal of the genus Homo out of Africa approximately 1.8 million years ago (Ma) has been understood within the context of changes in diet, behavior, and bipedal locomotor efficiency. While various morphological characteristics of the knee and ankle joints are considered part of a suite of traits indicative of, and functionally related to, habitual bipedal walking, the timing and phylogenetic details of these morphological changes remain unclear. To evaluate the timing of knee and ankle joint evolution, we apply geometric morphometric methods to three-dimensional digital models of the proximal and distal tibiae of fossil hominins, Holocene Homo sapiens, and extant great apes...
July 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28616546/late-gadolinium-enhancement-does-occur-in-tako-tsubo-cardiomyopathy-a-quantitative-cardiac-magnetic-resonance-and-speckle-tracking-strain-study
#16
Niranjan Gaikwad, Thomas Butler, Ryan Maxwell, Elizabeth Shaw, Wendy E Strugnell, Jonathan Chan, Gemma A Figtree, Richard E Slaughter, Christian Hamilton-Craig
BACKGROUND: Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) has been recommended to distinguish Tako-tsubo cardiomyopathy (TTC) from either acute myocardial infarction or myocarditis. METHOD: 44 consecutive patients with confirmed Mayo Clinic criteria for TTC underwent CMR imaging at 1.5 Tesla during the acute phase. 10 patients who had CMRI to exclude scar related ventricular tachycardia, and had negative studies, were used as negative controls...
September 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28613340/energy-transfer-from-colloidal-nanocrystals-to-strongly-absorbing-perovskites
#17
Yasiel Cabrera, Sara M Rupich, Ryan Shaw, Benoy Anand, Manuel de Anda Villa, Rezwanur Rahman, Aaron Dangerfield, Yuri N Gartstein, Anton V Malko, Yves J Chabal
Integration of colloidal nanocrystal quantum dots (NQDs) with strongly absorbing semiconductors offers the possibility of developing optoelectronic and photonic devices with new functionalities. We examine the process of energy transfer (ET) from photoactive CdSe/ZnS core/shell NQDs into lead-halide perovskite polycrystalline films as a function of distance from the perovskite surface using time-resolved photoluminescence (TRPL) spectroscopy. We demonstrate near-field electromagnetic coupling between vastly dissimilar excitation in two materials that can reach an efficiency of 99% at room temperature...
June 29, 2017: Nanoscale
https://www.readbyqxmd.com/read/28607831/primary-care-integration-of-psychiatric-and-behavioral-health-services-a-primer-for-providers-and-case-report-of-local-implementation
#18
Anthony Ps Guerrero, Cori L Takesue, Jared Hn Medeiros, Aileen A Duran, Joseph W Humphry, Ryan M Lunsford, Diana V Shaw, Michael H Fukuda, Earl S Hishinuma
Mental health conditions are common, disabling, potentially life-threatening, and costly; however, they are mostly treatable with early detection and intervention. Unfortunately, mental healthcare is in significantly short supply both nationally and locally, and particularly in small, rural, and relatively isolated communities. This article provides physicians and other health practitioners with a primer on the basic rationale and principles of integrating behavioral healthcare - particularly psychiatric specialty care - in primary care settings, including effective use of teleconferencing...
June 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28592496/male-infertility-is-responsible-for-nearly-half-of-the-extinction-observed-in-the-mouse-collaborative-cross
#19
John R Shorter, Fanny Odet, David L Aylor, Wenqi Pan, Chia-Yu Kao, Chen-Ping Fu, Andrew P Morgan, Seth Greenstein, Timothy A Bell, Alicia M Stevans, Ryan W Feathers, Sunny Patel, Sarah E Cates, Ginger D Shaw, Darla R Miller, Elissa J Chesler, Leonard McMillian, Deborah A O'Brien, Fernando Pardo-Manuel de Villena
The goal of the Collaborative Cross (CC) project was to generate and distribute over 1000 independent mouse recombinant inbred strains derived from eight inbred founders. With inbreeding nearly complete, we estimated the extinction rate among CC lines at a remarkable 95%, which is substantially higher than in the derivation of other mouse recombinant inbred populations. Here, we report genome-wide allele frequencies in 347 extinct CC lines. Contrary to expectations, autosomes had equal allelic contributions from the eight founders, but chromosome X had significantly lower allelic contributions from the two inbred founders with underrepresented subspecific origins (PWK/PhJ and CAST/EiJ)...
June 2017: Genetics
https://www.readbyqxmd.com/read/28546579/corrigendum-smchd1-mutations-associated-with-a-rare-muscular-dystrophy-can-also-cause-isolated-arhinia-and-bosma-arhinia-microphthalmia-syndrome
#20
Natalie D Shaw, Harrison Brand, Zachary A Kupchinsky, Hemant Bengani, Lacey Plummer, Takako I Jones, Serkan Erdin, Kathleen A Williamson, Joe Rainger, Alexei Stortchevoi, Kaitlin Samocha, Benjamin B Currall, Donncha S Dunican, Ryan L Collins, Jason R Willer, Angela Lek, Monkol Lek, Malik Nassan, Shahrin Pereira, Tammy Kammin, Diane Lucente, Alexandra Silva, Catarina M Seabra, Colby Chiang, Yu An, Morad Ansari, Jacqueline K Rainger, Shelagh Joss, Jill Clayton Smith, Margaret F Lippincott, Sylvia S Singh, Nirav Patel, Jenny W Jing, Jennifer R Law, Nalton Ferraro, Alain Verloes, Anita Rauch, Katharina Steindl, Markus Zweier, Ianina Scheer, Daisuke Sato, Nobuhiko Okamoto, Christina Jacobsen, Jeanie Tryggestad, Steven Chernausek, Lisa A Schimmenti, Benjamin Brasseur, Claudia Cesaretti, Jose E García-Ortiz, Tatiana Pineda Buitrago, Orlando Perez Silva, Jodi D Hoffman, Wolfgang Mühlbauer, Klaus W Ruprecht, Bart L Loeys, Masato Shino, Angela M Kaindl, Chie-Hee Cho, Cynthia C Morton, Richard R Meehan, Veronica van Heyningen, Eric C Liao, Ravikumar Balasubramanian, Janet E Hall, Stephanie B Seminara, Daniel Macarthur, Steven A Moore, Koh-Ichiro Yoshiura, James F Gusella, Joseph A Marsh, John M Graham, Angela E Lin, Nicholas Katsanis, Peter L Jones, William F Crowley, Erica E Davis, David R FitzPatrick, Michael E Talkowski
No abstract text is available yet for this article.
May 26, 2017: Nature Genetics
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