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REVIEW
Brianna L Scotland, Jacob R Shaw, Shruti Dharmaraj, Nicholas Caprio, Andrea L Cottingham, Jackline Joy Martín Lasola, Junsik J Sung, Ryan M Pearson
The prevalence of immune-mediated disorders, including autoimmune conditions and allergies, is steadily increasing. However, current therapeutic approaches are often non-specific and do not address the underlying pathogenic condition, often resulting in impaired immunity and a state of generalized immunosuppression. The emergence of technologies capable of selectively inhibiting aberrant immune activation in a targeted, antigen (Ag)-specific manner by exploiting the body's intrinsic tolerance pathways, all without inducing adverse side effects, holds significant promise to enhance patient outcomes...
November 17, 2023: Advanced Drug Delivery Reviews
#22
JOURNAL ARTICLE
Armaan Shetty, Qiuyu Yang, Jane Pendergast, Glen Leverson, Ryan Shaw, Corrine I Voils, Kara L Gavin
PURPOSE: Understand how weekly monetary incentives for dietary tracking and/or weight loss impact 6-month weight loss behavioral adherence. DESIGN: Secondary analysis of participants randomized to one of four conditions in a behavioral weight loss intervention: incentives for dietary tracking, incentives for weight loss, both, or none. SETTING: Participants were asked to self-weigh at least twice weekly, log food and drink in a mobile application five days weekly, and attend bi-weekly, group-based classes...
November 9, 2023: American Journal of Health Promotion: AJHP
#23
JOURNAL ARTICLE
Ryan J Shaw
Access to and the skills to use technology provide the digital equity necessary for civic and cultural participation, employment, lifelong learning, and access to essential services. However, existing digital disparities and the resultant 'digital divide' risk exacerbating health and health-care inequalities. The COVID-19 pandemic amplified these disparities and accelerated the adoption of technology-driven health care such as telehealth, electronic health records, and digital health technologies. Unfortunately, pre-existing disparities influence the adoption and utilization of these technologies, often leaving disadvantaged groups further behind...
August 2023: Creative Nursing
#24
JOURNAL ARTICLE
Fiona P Havers, Michael Whitaker, Michael Melgar, Bhoomija Chatwani, Shua J Chai, Nisha B Alden, James Meek, Kyle P Openo, Patricia A Ryan, Sue Kim, Ruth Lynfield, Yomei P Shaw, Grant Barney, Brenda L Tesini, Melissa Sutton, H Keipp Talbot, Kristen P Olsen, Monica E Patton
Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in older adults. In May 2023, two RSV vaccines were approved for prevention of RSV lower respiratory tract disease in adults aged ≥60 years. In June 2023, CDC recommended RSV vaccination for adults aged ≥60 years, using shared clinical decision-making. Using data from the Respiratory Syncytial Virus-Associated Hospitalization Surveillance Network, a population-based hospitalization surveillance system operating in 12 states, this analysis examined characteristics (including age, underlying medical conditions, and clinical outcomes) of 3,218 adults aged ≥60 years who were hospitalized with laboratory-confirmed RSV infection during July 2022-June 2023...
October 18, 2023: American Journal of Transplantation
#25
JOURNAL ARTICLE
Brad Wipfli, Sean P M Rice, Ryan Olson, Kasey Ha, Caitlyn Trullinger-Dwyer, Todd Bodner
BACKGROUND: Truck driving is a highly sedentary occupation that places workers at risk for chronic health conditions, such as obesity and high blood pressure. The primary purpose of this study was to objectively describe truck drivers' typical physical activity (PA) patterns. METHODS: We used ∼7-10-day baseline PA actigraphy data samples from drivers in the Safety & Health Involvement For Truckers (SHIFT) study ( n = 394). Driver PA patterns (e...
September 2023: Safety and Health At Work
#26
JOURNAL ARTICLE
Fiona P Havers, Michael Whitaker, Michael Melgar, Bhoomija Chatwani, Shua J Chai, Nisha B Alden, James Meek, Kyle P Openo, Patricia A Ryan, Sue Kim, Ruth Lynfield, Yomei P Shaw, Grant Barney, Brenda L Tesini, Melissa Sutton, H Keipp Talbot, Kristen P Olsen, Monica E Patton
Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in older adults. In May 2023, two RSV vaccines were approved for prevention of RSV lower respiratory tract disease in adults aged ≥60 years. In June 2023, CDC recommended RSV vaccination for adults aged ≥60 years, using shared clinical decision-making. Using data from the Respiratory Syncytial Virus-Associated Hospitalization Surveillance Network, a population-based hospitalization surveillance system operating in 12 states, this analysis examined characteristics (including age, underlying medical conditions, and clinical outcomes) of 3,218 adults aged ≥60 years who were hospitalized with laboratory-confirmed RSV infection during July 2022-June 2023...
October 6, 2023: MMWR. Morbidity and Mortality Weekly Report
#27
JOURNAL ARTICLE
Ryan A Denu, Richard K Yang, Alexander J Lazar, Shalin S Patel, Valerae O Lewis, Jason Roszik, J Andrew Livingston, Wei-Lien Wang, Kenna R Shaw, Ravin Ratan, Maria A Zarzour, Justin Bird, Shaan M Raza, Kadir C Akdemir, Jordi Rodon Ahnert, Vivek Subbiah, Shreyaskumar Patel, Anthony P Conley
PURPOSE: Chondrosarcomas are the most common primary bone tumor in adults. IDH1 and IDH2 mutations are prevalent. We aimed to assess the clinico-genomic properties of IDH mutant versus IDH wild type (WT) chondrosarcomas as well as alterations in other genes. METHODS: We included 93 patients with conventional and dedifferentiated chondrosarcoma for which there was available clinical next generation sequencing data. Clinical and genomic data were extracted and compared between IDH mutant and IDH WT chondrosarcomas and between TP53 mutant and TP53 WT chondrosarcomas...
September 25, 2023: Clinical Cancer Research
#28
JOURNAL ARTICLE
Denis E Bergeron, Richard Essex, Svetlana Nour, Gordon A Shaw, R Michael Verkouteren, Ryan P Fitzgerald
A manual microliter gravimetric dispensing technique is demonstrated using a micropipettor modified for use with removeable microcapillaries. Liquid scintillation sources were prepared from a well-characterized 241 Am reference solution, providing a radiometric check of dispensed masses. Further experiments confirmed controlled dispensing of drops onto gold foils with losses ≤0.34(4) % of the total drop activity. A detailed measurement equation for the weighing technique, including the corrections for evaporation, is presented with a full accounting of associated uncertainties...
September 9, 2023: Applied Radiation and Isotopes
#29
JOURNAL ARTICLE
Abigail Kelly, Sam C Went, Giuseppina Mariano, Liam P Shaw, David M Picton, Samuel J Duffner, Isabel Coates, Ryan Herdman-Grant, Julia Gordeeva, Alena Drobiazko, Artem Isaev, Yan-Jiun Lee, Yvette Luyten, Richard D Morgan, Peter Weigele, Konstantin Severinov, Nicolas Wenner, Jay C D Hinton, Tim R Blower
Bacteriophages (phages) outnumber bacteria ten-to-one and cause infections at a rate of 1025 per second. The ability of phages to reduce bacterial populations makes them attractive alternative antibacterials for use in combating the rise in antimicrobial resistance. This effort may be hindered due to bacterial defenses such as Bacteriophage Exclusion (BREX) that have arisen from the constant evolutionary battle between bacteria and phages. For phages to be widely accepted as therapeutics in Western medicine, more must be understood about bacteria-phage interactions and the outcomes of bacterial phage defense...
September 5, 2023: Applied and Environmental Microbiology
#30
JOURNAL ARTICLE
Jing Li, Bradley Richmond, Ahmad A Cluntun, Ryan Bia, Maureen A Walsh, Kikuyo Shaw, J David Symons, Sarah Franklin, Jared Rutter, Katsuhiko Funai, Robin M Shaw, TingTing Hong
Diabetic cardiomyopathy, an increasingly global epidemic and a major cause of heart failure with preserved ejection fraction (HFpEF), is associated with hyperglycemia, insulin resistance, and intra-cardiomyocyte calcium mishandling. Here we identify that, in db/db mice with type 2 diabetes induced HFpEF, abnormal remodeling of cardiomyocyte transverse-tubule microdomains occurs with downregulation of the membrane scaffolding protein cardiac bridging integrator 1 (cBIN1). Transduction of cBIN1 by AAV9 gene therapy can restore transverse-tubule microdomains to normalize intracellular distribution of calcium handling proteins and, surprisingly, glucose transporter 4 (GLUT4)...
August 24, 2023: JCI Insight
#31
JOURNAL ARTICLE
Kara L Gavin, Emily J Almeida, Corrine I Voils, Melissa M Crane, Ryan Shaw, William S Yancy, Jane Pendergast, Maren K Olsen
INTRODUCTION: Obtaining body weights remotely could improve feasibility of pragmatic trials. This investigation examined whether weights collected via cellular scale or electronic health record (EHR) correspond to gold standard in-person study weights. METHODS: The agreement of paired weight measurements from cellular scales were compared to study scales from a weight loss intervention and EHR-collected weights were compared to study scales from a weight loss maintenance intervention...
August 2023: Obesity Science & Practice
#32
JOURNAL ARTICLE
Anya Bauer, Emily Lindemuth, Francesco Elia Marino, Ryan Krause, Jaimy Joy, Steffen S Docken, Suvadip Mallick, Kevin McCormick, Clinton Holt, Ivelin Georgiev, Barbara Felber, Brandon F Keele, Ronald Veazey, Miles P Davenport, Hui Li, George M Shaw, Katharine J Bar
Transmitted/founder (TF) simian-human immunodeficiency viruses (SHIVs) express HIV-1 envelopes modified at position 375 to efficiently infect rhesus macaques while preserving authentic HIV-1 Env biology. SHIV.C.CH505 is an extensively characterized virus encoding the TF HIV-1 Env CH505 mutated at position 375 shown to recapitulate key features of HIV-1 immunobiology, including CCR5-tropism, a tier 2 neutralization profile, reproducible early viral kinetics, and authentic immune responses. SHIV.C.CH505 is used frequently in nonhuman primate studies of HIV, but viral loads after months of infection are variable and typically lower than those in people living with HIV...
July 3, 2023: PLoS Pathogens
#33
MULTICENTER STUDY
Nizar Hakam, Sorena Keihani, Nathan M Shaw, Behzad Abbasi, Charles P Jones, Douglas Rogers, Sherry S Wang, Joel A Gross, Ryan P Joyce, Judith C Hagedorn, J Patrick Selph, Rachel L Sensenig, Rachel A Moses, Christopher M Dodgion, Shubham Gupta, Kaushik Mukherjee, Sarah Majercik, Brian P Smith, Joshua A Broghammer, Ian Schwartz, Nima Baradaran, Scott A Zakaluzny, Bradley A Erickson, Brandi D Miller, Reza Askari, Matthew M Carrick, Frank N Burks, Scott Norwood, Jeremy B Myers, Benjamin N Breyer
PURPOSE: To investigate management trends for American Association for the Surgery of Trauma (AAST) grade V renal trauma with focus on non-operative management. METHODS: We used prospectively collected data as part of the Multi-institutional Genito-Urinary Trauma Study (MiGUTS). We included patients with grade V renal trauma according to the AAST Injury Scoring Scale 2018 update. All cases submitted by participating centers with radiology images available were independently reviewed to confirm renal trauma grade...
July 2023: World Journal of Urology
#34
JOURNAL ARTICLE
Ryan Gage, Anja Mizdrak, Justin Richards, Adrian Bauman, Melissa Mcleod, Rhys Jones, Alistair Woodward, Caroline Shaw
BACKGROUND: Surveillance of domain-specific physical activity (PA) helps to target interventions to promote PA. We examined the sociodemographic correlates of domain-specific PA in New Zealand adults. METHODS: A nationally representative sample of 13,887 adults completed the International PA Questionnaire-long form in 2019/20. Three measures of total and domain-specific (leisure, travel, home, and work) PA were calculated: (1) weekly participation, (2) mean weekly metabolic energy equivalent minutes (MET-min), and (3) median weekly MET-min among those who undertook PA...
June 8, 2023: Journal of Physical Activity & Health
#35
JOURNAL ARTICLE
Mya Tran, Shannon Palmer, Dominic T Moore, Luther Bartelt, Anne Friedland, Tatjana Grgic, Anne Lachiewicz, Jon Ptachcinski, Arlene Sena, Morgan Trepte, David van Duin, Tessa M Andermann, Ryan Shaw
The utility of obtaining screening urine cultures for febrile neutropenia (FN) during hematopoietic stem cell transplant (HCT) is unknown. In 667 adult HCT patients with FN, only 40 (6%) were found with bacteriuria. Antibiotics were modified in 3 patients (0.4%) based on urine cultures and none developed urinary-associated infectious complications.
May 2023: Open Forum Infectious Diseases
#36
JOURNAL ARTICLE
Yubing Li, Clay Abraham, Oleg Suslov, Ozlem Yaren, Ryan W Shaw, Myong-Jung Kim, Shuo Wan, Philippe Marliere, Steven A Benner
One horizon in synthetic biology seeks alternative forms of DNA that store, transcribe, and support the evolution of biological information. Here, hydrogen bond donor and acceptor groups are rearranged within a Watson-Crick geometry to get 12 nucleotides that form 6 independently replicating pairs. Such artificially expanded genetic information systems (AEGIS) support Darwinian evolution in vitro . To move AEGIS into living cells, metabolic pathways are next required to make AEGIS triphosphates economically from their nucleosides, eliminating the need to feed these expensive compounds in growth media...
June 16, 2023: ACS Synthetic Biology
#37
JOURNAL ARTICLE
Michael D Healy, Kerrie E McNally, Rebeka Butkovič, Molly Chilton, Kohji Kato, Joanna Sacharz, Calum McConville, Edmund R R Moody, Shrestha Shaw, Vicente J Planelles-Herrero, Sathish K N Yadav, Jennifer Ross, Ufuk Borucu, Catherine S Palmer, Kai-En Chen, Tristan I Croll, Ryan J Hall, Nikeisha J Caruana, Rajesh Ghai, Thi H D Nguyen, Kate J Heesom, Shinji Saitoh, Imre Berger, Christiane Schaffitzel, Tom A Williams, David A Stroud, Emmanuel Derivery, Brett M Collins, Peter J Cullen
The Commander complex is required for endosomal recycling of diverse transmembrane cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies: Retriever composed of VPS35L, VPS26C, and VPS29; and the CCC complex which contains twelve subunits: COMMD1-COMMD10 and the coiled-coil domain-containing (CCDC) proteins CCDC22 and CCDC93. Combining X-ray crystallography, electron cryomicroscopy, and in silico predictions, we have assembled a complete structural model of Commander. Retriever is distantly related to the endosomal Retromer complex but has unique features preventing the shared VPS29 subunit from interacting with Retromer-associated factors...
May 11, 2023: Cell
#38
JOURNAL ARTICLE
Lili Zhou, Ryan McAdow, Hunter Yamada, Brooke Burris, Dana Klatt Shaw, Kelsey Oonk, Kenneth D Poss, Mayssa H Mokalled
Unlike mammals, adult zebrafish undergo spontaneous recovery after major spinal cord injury. Whereas reactive gliosis presents a roadblock for mammalian spinal cord repair, glial cells in zebrafish elicit pro-regenerative bridging functions after injury. Here, we perform genetic lineage tracing, assessment of regulatory sequences, and inducible cell ablation to define mechanisms that direct the molecular and cellular responses of glial cells after spinal cord injury in adult zebrafish. Using a newly generated CreERT2 transgenic line, we show cells that direct expression of the bridging glial marker ctgfa give rise to regenerating glia after injury, with negligible contribution to either neuronal or oligodendrocyte lineages...
May 9, 2023: Development
#39
JOURNAL ARTICLE
Tyler C Dunlap, Daniel L Weiner, Ryan M Kemper, Miramar Kardouh, Susanna C DeVane, Allison Symonds, J Ryan Shaw, Paul M Armistead, Jonathan R Ptachcinski, Daniel J Crona
Busulfan is an alkylating agent used as part of conditioning chemotherapy regimens prior to allogeneic hematopoietic cell transplant (allo-HCT). Pharmacokinetic (PK)-guided test-dose strategies have been shown to improve the number of patients achieving busulfan exposure goals and improve clinical outcomes. However, current practices require extensive PK sampling. In this study, PK data were retrospectively collected from busulfan drug monitoring records from adult allo-HCT recipients who received once-daily intravenous busulfan at University of North Carolina Medical Center (UNCMC)...
April 30, 2023: Journal of Clinical Pharmacology
#40
JOURNAL ARTICLE
Ru-Sen Lu, Keiichi Asada, Thomas P Krichbaum, Jongho Park, Fumie Tazaki, Hung-Yi Pu, Masanori Nakamura, Andrei Lobanov, Kazuhiro Hada, Kazunori Akiyama, Jae-Young Kim, Ivan Marti-Vidal, José L Gómez, Tomohisa Kawashima, Feng Yuan, Eduardo Ros, Walter Alef, Silke Britzen, Michael Bremer, Avery E Broderick, Akihiro Doi, Gabriele Giovannini, Marcello Giroletti, Paul T P Ho, Mareki Honma, David H Hughes, Makoto Inoue, Wu Jiang, Motoki Kino, Shoko Koyama, Michael Lindqvist, Jun Liu, Alan P Marscher, Satoki Matsushita, Hiroshi Nagai, Helge Rottmann, Tuomas Savolainen, Karl-Friedrich Schuster, Zhi-Qiang Shen, Pablo de Vicente, R Craig Walker, Hai Yang, J Anton Zensus, Juan Carlos Algaba, Alexander Allardi, Uwe Bach, Ryan Berthold, Dan Bintley, Do-Young Byun, Carolina Casadio, Shu-Hao Chang, Chih-Cheng Chang, Song-Chu Chang, Chung-Chen Chen, Ming-Tang Chen, Ryan Chilson, Tim C Chuter, John Conway, Geoffrey B Crew, Jessica T Dempsey, Sven Dornbusch, Aaron Faber, Per Friberg, Javier González García, Miguel Gómez Garrido, Chih-Chiang Han, Kuo-Chang Han, Yutaka Hasegawa, Ruben Herrero-Illana, Yau-De Huang, Chih-Wei L Huang, Violette Impellizzeri, Homin Jiang, Hao Jinchi, Taehyun Jung, Juha Kallunki, Petri Kirves, Kimihiro Kimura, Jun Yi Koay, Patrick M Koch, Carsten Kramer, Alex Kraus, Derek Kubo, Cheng-Yu Kuo, Chao-Te Li, Lupin Chun-Che Lin, Ching-Tang Liu, Kuan-Yu Liu, Wen-Ping Lo, Li-Ming Lu, Nicholas MacDonald, Pierre Martin-Cocher, Hugo Messias, Zheng Meyer-Zhao, Anthony Minter, Dhanya G Nair, Hiroaki Nishioka, Timothy J Norton, George Nystrom, Hideo Ogawa, Peter Oshiro, Nimesh A Patel, Ue-Li Pen, Yurii Pidopryhora, Nicolas Pradel, Philippe A Raffin, Ramprasad Rao, Ignacio Ruiz, Salvador Sanchez, Paul Shaw, William Snow, T K Sridharan, Ranjani Srinivasan, Belén Tercero, Pablo Torne, Efthalia Traianou, Jan Wagner, Craig Walther, Ta-Shun Wei, Jun Yang, Chen-Yu Yu
The nearby radio galaxy M87 is a prime target for studying black hole accretion and jet formation1,2 . Event Horizon Telescope observations of M87 in 2017, at a wavelength of 1.3 mm, revealed a ring-like structure, which was interpreted as gravitationally lensed emission around a central black hole3 . Here we report images of M87 obtained in 2018, at a wavelength of 3.5 mm, showing that the compact radio core is spatially resolved. High-resolution imaging shows a ring-like structure of [Formula: see text] Schwarzschild radii in diameter, approximately 50% larger than that seen at 1...
April 2023: Nature
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