Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
Corrine Voils, Ryan Shaw, Kara Gavin, Scott Hetzel, Megan Lewis, Samantha Pabich, Heather Johnson, Felix Elwert, Lu Mao, Kristen Gray, Alice Yuroff, Katya Garza, William Yancy, Laura Porter
Background: Partner support is associated with better weight loss outcomes in observational studies, but randomized trials show mixed results for including partners. Unclear is whether teaching communication skills to couples will improve weight loss in index participants. Purpose: To compare the efficacy of a partner-assisted intervention versus participant-only weight management program on long-term weight loss. Methods: This community-based study took place in Madison, WI. Index participants were eligible if they met obesity guideline criteria to receive weight loss counseling, were aged 74 years or younger, lived with a partner, and had no medical contraindications to weight loss; partners were aged 74 years or younger and not underweight...
March 11, 2024: Research Square
#2
JOURNAL ARTICLE
Changxia Shi, Nicholas A Rorrer, Alexander L Shaw, Ryan W Clarke, Bonnie L Buss, Gregg T Beckham, Linda J Broadbelt, Eugene Y-X Chen
Despite considerable recent advances already made in developing chemically circular polymers (CPs), the current framework predominantly focuses on CPs with linear-chain structures of different monomer types. As polymer properties are determined by not only composition but also topology, manipulating the topology of the single-monomer-based CP systems from linear-chain structures to architecturally complex polymers could potentially modulate the resulting polymer properties without changing the chemical composition, thereby advancing the concept of monomaterial product design...
March 22, 2024: Journal of the American Chemical Society
#3
JOURNAL ARTICLE
Qing Yang, Meilin Jiang, Cai Li, Sheng Luo, Matthew J Crowley, Ryan J Shaw
BACKGROUND: Intensive longitudinal data (ILD) collected in near real time by mobile health devices provide a new opportunity for monitoring chronic diseases, early disease risk prediction, and disease prevention in health research. Functional data analysis, specifically functional principal component analysis, has great potential to abstract trends in ILD but has not been used extensively in mobile health research. OBJECTIVE: To introduce functional principal component analysis (fPCA) and demonstrate its potential applicability in estimating trends in ILD collected by mobile heath devices, assessing longitudinal association between ILD and health outcomes, and predicting health outcomes...
March 17, 2024: BMC Medical Research Methodology
#4
JOURNAL ARTICLE
Scott R Auerbach, Adam Arshad, Estela Azeka, Ryan S Cantor, James K Kirklin, Devin Koehl, JonDavid Menteer, David M Peng, William Ravekes, Fawwaz R Shaw, Renata Shih, Jacob Simmonds, Jean Ballweg
BACKGROUND: Impacts of ischemic time (IT) on pediatric heart transplant outcomes are multifactorial. We aimed to analyze the effect of prolonged IT on graft loss after pediatric heart transplantation. We hypothesized that graft survival with prolonged IT has improved across eras. METHODS: Patients <18 years old in the Pediatric Heart Transplant Society database were included (N=6,765) and stratified by diagnosis and era (1993-2004, 2005-2009, and 2010-2019). Severe graft failure (SGF) was defined as death, retransplant, or need for mechanical circulatory support in the first 7 days post-transplant...
March 7, 2024: Journal of Heart and Lung Transplantation
#5
JOURNAL ARTICLE
Eamonn Byrnes, Brian Shaw, Ryan Shaw, Mario Madruga, Stephen J Carlan
BACKGROUND Cysticercosis is a condition caused by infection with the larval form of Taenia solium, a pork tapeworm that uses pigs as an intermediate host. Humans become infected when they ingest water or food contaminated with tapeworm cysts. Cysticercosis is increasing in frequency in developed countries due to increased access to travel. Neurocysticercosis occurs when Taenia solium cysts embed within the nervous system. The clinical presentation of neurocysticercosis ranges from asymptomatic to life-threatening, largely depending on the brain parenchymal involvement...
March 7, 2024: American Journal of Case Reports
#6
MULTICENTER STUDY
Shankar Siva, Mathias Bressel, Mark Sidhom, Swetha Sridharan, Ben G L Vanneste, Ryan Davey, Rebecca Montgomery, Jeremy Ruben, Farshad Foroudi, Braden Higgs, Charles Lin, Avi Raman, Nicholas Hardcastle, Michael S Hofman, Richard De Abreu Lourenco, Mark Shaw, Pascal Mancuso, Daniel Moon, Lih-Ming Wong, Nathan Lawrentschuk, Simon Wood, Nicholas R Brook, Tomas Kron, Jarad Martin, David Pryor
BACKGROUND: Stereotactic ablative body radiotherapy (SABR) is a novel non-invasive alternative for patients with primary renal cell cancer who do not undergo surgical resection. The FASTRACK II clinical trial investigated the efficacy of SABR for primary renal cell cancer in a phase 2 trial. METHODS: This international, non-randomised, phase 2 study was conducted in seven centres in Australia and one centre in the Netherlands. Eligible patients aged 18 years or older had biopsy-confirmed diagnosis of primary renal cell cancer, with only a single lesion; were medically inoperable, were at high risk of complications from surgery, or declined surgery; and had an Eastern Cooperative Oncology Group performance status of 0-2...
March 2024: Lancet Oncology
#7
JOURNAL ARTICLE
Ryan T Lin, Jonathan F Dalton, Christopher J Como, Audrey Y Chang, Melissa Yunting Tang, Anthony A Oyekan, Shaan Sadhwani, Richard A Wawrose, Joon Y Lee, Jeremy D Shaw
STUDY DESIGN: Retrospective cohort. OBJECTIVE: To evaluate the clinical relevance, usefulness, and financial implications of intraoperative radiograph interpretation by radiologists in spine surgery. SUMMARY OF BACKGROUND DATA: Due to rising healthcare costs, spine surgery is under scrutiny to maximize value-based care. Formal radiographic analysis remains a potential source of unnecessary healthcare costs, especially for intra-operative radiographs...
February 26, 2024: Spine
#8
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
#9
JOURNAL ARTICLE
A Anilkumar, W Högler, J Bursell, R Nadar, F Ryan, T Randell, N J Shaw, S Uday
BACKGROUND: Ectopic calcification is inappropriate biomineralization of soft tissues occurring due to genetic or acquired causes of hyperphosphataemia and rarely in normophosphataemic individuals. Tumoral Calcinosis (TC) is a rare metabolic bone disorder commonly presenting in childhood and adolescence with periarticular extra-capsular calcinosis. Three subtypes of TC have been recognised: primary hyperphosphataemic familial TC (HFTC), primary normophosphataemic familial TC and secondary TC most commonly seen in chronic renal failure...
February 14, 2024: Bone
#10
JOURNAL ARTICLE
Nicolas Artz, Jonathan Dalton, Rahul Ramanathan, Ryan T Lin, Shaan Sadhwani, Vivian Li, Josephine Nwankwo, Christopher J Como, Anthony Oyekan, Yunting Melissa Tang, Joon Y Lee, Jeremy D Shaw
DESIGN: Retrospective review. OBJECTIVE: Characterize negative reviews of spine surgeons in the United States. SUMMARY: Physician rating websites significantly influence the selection of doctors by other patients. Negative experiences are impacted by various factors, both clinical and nonclinical, geography, and practice structure. The purpose of this study was to evaluate and categorize negative reviews of spine surgeons in the United States, with a focus on surgical versus nonsurgical reviewers...
February 14, 2024: Spine
#11
JOURNAL ARTICLE
Émilie Degagné, Paul D Donohoue, Suparna Roy, Jessica Scherer, Tristan W Fowler, Ryan T Davis, Gustavo A Reyes, George Kwong, Morena Stanaway, Vanina Larroca Vicena, Devin Mutha, Raymond Guo, Leslie Edwards, Benjamin Schilling, McKay Shaw, Stephen C Smith, Bryan Kohrs, Heinrich J Kufeldt, Glen Churchward, Finey Ruan, David B Nyer, Kyle McSweeney, Matthew J Irby, Christopher K Fuller, Lynda Banh, Mckenzi S Toh, Matthew Thompson, Arthur L G Owen, Zili An, Scott Gradia, Justin Skoble, Mara Bryan, Elizabeth Garner, Steven B Kanner
Allogeneic chimeric antigen receptor (CAR) T-cell therapies hold the potential to overcome many of the challenges associated with patient-derived (autologous) CAR T cells. Key considerations in the development of allogeneic CAR T-cell therapies include prevention of GvHD and suppression of allograft rejection. Here we describe preclinical data supporting the ongoing first-in-human clinical study, the CaMMouflage trial (NCT05722418), evaluating CB-011 in patients with relapsed/refractory multiple myeloma. CB-011 is a hypoimmunogenic, allogeneic anti-B cell maturation antigen (BCMA) CAR T-cell therapy candidate...
February 9, 2024: Cancer Immunology Research
#12
JOURNAL ARTICLE
Jeanna T Ryan, Heather Day, Marlene J Egger, Jiqiang Wu, Christopher M Depner, Janet M Shaw
OBJECTIVES: Approximately 75% of women weigh more at 1-year postpartum than pre-pregnancy. More than 47% retain >10 lbs at 1-year postpartum, which is associated with adverse health outcomes for mother and child. Disturbed sleep may contribute to risk of postpartum weight retention (PWR) as short sleep duration is associated with increased risk of obesity. Thus, we investigated whether night-time sleep duration is associated with risk for excessive PWR. We also explored night-time sleep duration and change in postpartum waist circumference...
2024: Sleep advances: a journal of the Sleep Research Society
#13
JOURNAL ARTICLE
Ryan J Shaw, Kristin Montgomery, Christopher Fiander, Kelcie Bullock, Ryan Craig, Gina Pennington, Matthew J Crowley
Telehealth has the potential to improve management of poorly controlled chronic diseases relative to clinic-based care alone. Mobile monitoring-enabled technologies could enhance telehealth for chronic illness care. Implementation in practice settings would rely on automated integration of data into the electronic health record (EHR). We describe the integration and visualization of data from four remote monitoring devices into the EHR that is coupled with the evaluation of an evidence-based nurse and pharmacist-led telehealth care model for patients with uncontrolled diabetes and hypertension...
January 25, 2024: Studies in Health Technology and Informatics
#14
JOURNAL ARTICLE
Ryan J Shaw, Matthew J Crowley
Mobile monitoring-enabled technologies could enhance telehealth for chronic illness care. EXTEND is an active comparator randomized trial (N=220) of two 24-month interventions: 1) mobile monitoring as a self-management tool (EXTEND); and 2) a 12-month nurse and pharmacist-delivered telehealth intervention incorporating mobile monitoring, self-management support, and medication management that is followed by a 12-month self-management period (EXTEND Plus). EXTEND Plus is a pragmatic approach to integrating mobile monitoring-enabled telehealth for patients uncontrolled diabetes and hypertension into existing clinical infrastructure...
January 25, 2024: Studies in Health Technology and Informatics
#15
JOURNAL ARTICLE
Noah Kojima, Christopher A Taylor, Mark W Tenforde, Dawud Ujamaa, Alissa O'Halloran, Kadam Patel, Shua J Chai, Pam Daily Kirley, Nisha B Alden, Breanna Kawasaki, James Meek, Kimberly Yousey-Hindes, Evan J Anderson, Kyle P Openo, Libby Reeg, Val Tellez Nunez, Ruth Lynfield, Kathryn Como-Sabetti, Susan L Ropp, Yomei P Shaw, Nancy L Spina, Grant Barney, Sophrena Bushey, Kevin Popham, Nancy E Moran, Eli Shiltz, Melissa Sutton, Nasreen Abdullah, H Keipp Talbot, William Schaffner, Ryan Chatelain, Andrea Price, Shikha Garg, Fiona P Havers, Catherine H Bozio
Severe outcomes were common among adults hospitalized for COVID-19 or influenza, while the percentage of COVID-19 hospitalizations involving critical care decreased from October 2021 to September 2022. During the Omicron BA.5 period, intensive care unit admission frequency was similar for COVID-19 and influenza, although patients with COVID-19 had a higher frequency of in-hospital death.
January 2024: Open Forum Infectious Diseases
#16
JOURNAL ARTICLE
Niall D H MacSweeney, Joseph W Shaw, George P Simkin, Charles R Pedlar, Phil D B Price, Ryan Mahaffey, Daniel D Cohen
BACKGROUND: Preprofessional ballet dancers are exposed to the risk of injuries, primarily in the lower extremities, with most injuries occurring during jumping and landing activities. Interlimb asymmetry during jumping and landing activities has been associated with the injury risk in adolescent athletes, but this has not been examined in dancers. PURPOSE: To investigate associations between interlimb asymmetry during a double-leg countermovement jump (DL-CMJ) and single-leg jump (SLJ) and the injury risk in adolescent preprofessional ballet dancers...
January 22, 2024: American Journal of Sports Medicine
#17
JOURNAL ARTICLE
Lucas W Souza, Beck R Miller, Ryan C Cammarota, Anna Lo, Ixchel Lopez, Yuan-Shin Shiue, Benjamin D Bergstrom, Sarah N Dishman, James C Fettinger, Matthew S Sigman, Jared T Shaw
Interactions between catalysts and substrates can be highly complex and dynamic, often complicating the development of models to either predict or understand such processes. A dirhodium(II)-catalyzed C-H insertion of donor/donor carbenes into 2-alkoxybenzophenone substrates to form benzodihydrofurans was selected as a model system to explore nonlinear methods to achieve a mechanistic understanding. We found that the application of traditional methods of multivariate linear regression (MLR) correlating DFT-derived descriptors of catalysts and substrates leads to poorly performing models...
January 5, 2024: ACS Catalysis
#18
JOURNAL ARTICLE
Nhu Truong, Andrea L Cottingham, Shruti Dharmaraj, Jacob R Shaw, Jackline Joy Martin Lasola, Christopher C Goodis, Steven Fletcher, Ryan M Pearson
Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA-OH), was incorporated into immunomodulatory poly(lactic acid)-based nanoparticles (iNP-SAHA) by employing a prodrug approach through the covalent modification of poly(lactic-co-glycolic acid) (PLGA) with SAHA-OH. iNP-SAHA formulation allowed for controlled incorporation and delivery of SAHA-OH from iNP-SAHA and treatment led to multimodal biological responses including significant reductions in proinflammatory cytokine secretions and gene expression, while increasing the survival of primary macrophages under lipopolysaccharide (LPS) challenge...
January 2024: Bioengineering & Translational Medicine
#19
JOURNAL ARTICLE
Angela I Renton, Thuy T Dao, Tom Johnstone, Oren Civier, Ryan P Sullivan, David J White, Paris Lyons, Benjamin M Slade, David F Abbott, Toluwani J Amos, Saskia Bollmann, Andy Botting, Megan E J Campbell, Jeryn Chang, Thomas G Close, Monika Dörig, Korbinian Eckstein, Gary F Egan, Stefanie Evas, Guillaume Flandin, Kelly G Garner, Marta I Garrido, Satrajit S Ghosh, Martin Grignard, Yaroslav O Halchenko, Anthony J Hannan, Anibal S Heinsfeld, Laurentius Huber, Matthew E Hughes, Jakub R Kaczmarzyk, Lars Kasper, Levin Kuhlmann, Kexin Lou, Yorguin-Jose Mantilla-Ramos, Jason B Mattingley, Michael L Meier, Jo Morris, Akshaiy Narayanan, Franco Pestilli, Aina Puce, Fernanda L Ribeiro, Nigel C Rogasch, Chris Rorden, Mark M Schira, Thomas B Shaw, Paul F Sowman, Gershon Spitz, Ashley W Stewart, Xincheng Ye, Judy D Zhu, Aswin Narayanan, Steffen Bollmann
Neuroimaging research requires purpose-built analysis software, which is challenging to install and may produce different results across computing environments. The community-oriented, open-source Neurodesk platform ( https://www.neurodesk.org/ ) harnesses a comprehensive and growing suite of neuroimaging software containers. Neurodesk includes a browser-accessible virtual desktop, command-line interface and computational notebook compatibility, allowing for accessible, flexible, portable and fully reproducible neuroimaging analysis on personal workstations, high-performance computers and the cloud...
January 8, 2024: Nature Methods
#20
Ian S Cohn, Bethan A Wallbank, Breanne E Haskins, Keenan M O'Dea, Ryan D Pardy, Sebastian Shaw, Maria I Merolle, Jodi A Gullicksrud, David A Christian, Boris Striepen, Christopher A Hunter
UNLABELLED: Cryptosporidium is an enteric pathogen that is a prominent cause of diarrheal disease. Control of this infection requires CD4 + T cells, though the processes that lead to T cell-mediated resistance have been difficult to assess. Here, Cryptosporidium parasites that express MHCII-restricted model antigens were generated to dissect the early events that influence CD4 + T cell priming and effector function. These studies highlight that parasite-specific CD4 + T cells are primed in the draining mesenteric lymph node (mesLN) and differentiate into Th1 cells in the gut, where they mediate IFN-γ-dependent control of the infection...
November 13, 2023: bioRxiv
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
