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https://www.readbyqxmd.com/read/29675680/a-randomized-double-blind-phase-2-study-of-ruxolitinib-or-placebo-in-combination-with-capecitabine-in-patients-with-advanced-her2-negative-breast-cancer-and-elevated-c-reactive-protein-a-marker-of-systemic-inflammation
#1
Joyce O'Shaughnessy, Angela DeMichele, Cynthia X Ma, Paul Richards, Denise A Yardley, Gail Shaw Wright, Kevin Kalinsky, Ronald Steis, Sami Diab, Gerard Kennealey, Ryan Geschwindt, Wei Jiang, Hope S Rugo
PURPOSE: The Janus-associated kinase (JAK)/signal transducer and activator of transcription pathway is a key regulator of inflammatory signaling, associated with tumorigenesis, cell survival, and progression. This randomized phase 2 trial evaluated the efficacy and safety of the addition of ruxolitinib, a JAK1/JAK2 inhibitor, to capecitabine in patients with HER2-negative advanced breast cancer and high systemic inflammation (modified Glasgow Prognostic Score [mGPS] ≥ 1). METHODS: Patients with ≤ 2 prior chemotherapy regimens for advanced or metastatic disease or hormone receptor-positive patients with disease progression on prior hormonal therapies were randomized 1:1 to 21-day cycles of ruxolitinib (n = 76) or placebo (n = 73) plus capecitabine...
April 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29599409/functional-precision-medicine-identifies-novel-druggable-targets-and-therapeutic-options-in-head-and-neck-cancer
#2
Chang Xu, Olga Nikolova, Ryan Basom, Ryan M Mitchell, Reid Shaw, Russell Moser, Heuijoon Park, Kay E Gurley, Micheal Kao, Carlos L Green, Franz X Schaub, Robert L Diaz, Hallie A Swan, In Sock Jang, Justin Guinney, Vijayakrishna K Gadi, Adam A Margolin, Carla Grandori, Christopher J Kemp, Eduardo Méndez
PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with high mortality and a lack of targeted therapies. To identify and prioritize druggable targets, we performed genome analysis together with genome-scale siRNA and oncology drug profiling using low passage tumor cells derived from a patient with a treatmentresistant HPV-negative HNSCC. EXPERIMENTAL DESIGN: A tumor cell culture was established and subjected to whole exome sequencing, RNA sequencing, comparative genome hybridization, and high-throughput phenotyping with siRNA library covering the druggable genome and an oncology drug library...
March 29, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29509865/radical-prostatectomy-external-beam-radiotherapy-or-external-beam-radiotherapy-with-brachytherapy-boost-and-disease-progression-and-mortality-in-patients-with-gleason-score-9-10-prostate-cancer
#3
MULTICENTER STUDY
Amar U Kishan, Ryan R Cook, Jay P Ciezki, Ashley E Ross, Mark M Pomerantz, Paul L Nguyen, Talha Shaikh, Phuoc T Tran, Kiri A Sandler, Richard G Stock, Gregory S Merrick, D Jeffrey Demanes, Daniel E Spratt, Eyad I Abu-Isa, Trude B Wedde, Wolfgang Lilleby, Daniel J Krauss, Grace K Shaw, Ridwan Alam, Chandana A Reddy, Andrew J Stephenson, Eric A Klein, Daniel Y Song, Jeffrey J Tosoian, John V Hegde, Sun Mi Yoo, Ryan Fiano, Anthony V D'Amico, Nicholas G Nickols, William J Aronson, Ahmad Sadeghi, Stephen Greco, Curtiland Deville, Todd McNutt, Theodore L DeWeese, Robert E Reiter, Johnathan W Said, Michael L Steinberg, Eric M Horwitz, Patrick A Kupelian, Christopher R King
Importance: The optimal treatment for Gleason score 9-10 prostate cancer is unknown. Objective: To compare clinical outcomes of patients with Gleason score 9-10 prostate cancer after definitive treatment. Design, Setting, and Participants: Retrospective cohort study in 12 tertiary centers (11 in the United States, 1 in Norway), with 1809 patients treated between 2000 and 2013. Exposures: Radical prostatectomy (RP), external beam radiotherapy (EBRT) with androgen deprivation therapy, or EBRT plus brachytherapy boost (EBRT+BT) with androgen deprivation therapy...
March 6, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29440509/the-unfolded-protein-response-regulator-atf6-promotes-mesodermal-differentiation
#4
Heike Kroeger, Neil Grimsey, Ryan Paxman, Wei-Chieh Chiang, Lars Plate, Ying Jones, Peter X Shaw, JoAnn Trejo, Stephen H Tsang, Evan Powers, Jeffery W Kelly, R Luke Wiseman, Jonathan H Lin
ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress. Deletion of the isoform activating transcription factor 6α (ATF6α) and its paralog ATF6β results in embryonic lethality and notochord dysgenesis in nonhuman vertebrates, and loss-of-function mutations in ATF6α are associated with malformed neuroretina and congenital vision loss in humans. These phenotypes implicate an essential role for ATF6 during vertebrate development...
February 13, 2018: Science Signaling
https://www.readbyqxmd.com/read/29391249/spatial-and-single-cell-transcriptional-profiling-identifies-functionally-distinct-human-dermal-fibroblast-subpopulations
#5
Christina Philippeos, Stephanie Telerman, Bénédicte Oulès, Angela O Pisco, Tanya J Shaw, Raul Elgueta, Giovanna Lombardi, Ryan R Driskell, Mark Soldin, Magnus D Lynch, Fiona M Watt
Previous studies have shown that mouse dermis is comprised of functionally distinct fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin we have used a combination of comparative spatial transcriptional profiling of human and mouse dermis and single cell transcriptional profiling of human dermal fibroblasts. We show that there are at least four distinct fibroblast populations in adult human skin, not all of which are spatially segregated. We define markers permitting their isolation and show that although marker expression is lost in culture, different fibroblast subpopulations retain distinct functionality in terms of Wnt signalling, responsiveness to IFNγ and ability to support human epidermal reconstitution when introduced into decellularised dermis...
January 29, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#6
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/29389255/assessing-character-strengths-in-youth-with-intellectual-disability-reliability-and-factorial-validity-of-the-via-youth
#7
Karrie A Shogren, Leslie A Shaw, Sheida K Raley, Michael L Wehmeyer, Ryan M Niemiec, Megan Adkins
This article reports the results of an examination of the endorsement, reliability, and factorial validity of the VIA-Youth and assessment of character strengths and virtues developed for the general population in youth with and without intellectual disability. Findings suggest that, generally, youth with intellectual disability endorsed character strengths as being like them at lower levels, although few differences were significant. Issues related to measurement, particularly the establishment of measurement invariance, emerged for some virtues...
February 2018: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29344401/protocol-for-moving-on-a-randomized-controlled-trial-to-increase-outcome-expectations-and-exercise-among-breast-cancer-survivors
#8
Rachel Hirschey, Gretchen Kimmick, Marilyn Hockenberry, Ryan Shaw, Wei Pan, Isaac Lipkus
Aim: The aim of this study was to test the feasibility and fidelity of an intervention, Moving On, aimed to increase outcome expectations OEs (i.e. what one expects to obtain or avoid as a result of a behaviour) and exercise among breast cancer survivors. Design: Randomized controlled trial. Methods: Intervention arm participants will be given a theory-guided booklet that was co-created by the research team and three physically active breast cancer survivors who exercise to manage late and long-term treatment effects...
January 2018: Nursing Open
https://www.readbyqxmd.com/read/29299592/chemoprevention-of-basal-and-squamous-cell-carcinoma-with-a-single-course-of-fluorouracil-5-cream-a-randomized-clinical-trial
#9
Martin A Weinstock, Soe Soe Thwin, Julia A Siegel, Kimberly Marcolivio, Alexander D Means, Nicholas F Leader, Fiona M Shaw, Daniel Hogan, David Eilers, Susan M Swetter, Suephy C Chen, Sharon E Jacob, Erin M Warshaw, George P Stricklin, Robert P Dellavalle, Navjeet Sidhu-Malik, Nellie Konnikov, Victoria P Werth, Jonette E Keri, Leslie Robinson-Bostom, Robert J Ringer, Robert A Lew, Ryan Ferguson, John J DiGiovanna, Grant D Huang
Importance: Keratinocyte carcinoma (ie, cutaneous basal and squamous cell carcinoma) is the most common cancer in the United States. Objective: To determine whether topical fluorouracil could prevent surgically treated keratinocyte carcinoma. Design, Setting, and Participants: The Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial was a randomized, double-blind, placebo-controlled trial of topical fluorouracil for chemoprevention of keratinocyte carcinoma...
February 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29289702/study-protocol-for-log2lose-a-feasibility-randomized-controlled-trial-to-evaluate-financial-incentives-for-dietary-self-monitoring-and-interim-weight-loss-in-adults-with-obesity
#10
Corrine I Voils, Erica Levine, Jennifer M Gierisch, Jane Pendergast, Sarah L Hale, Megan A McVay, Shelby D Reed, William S Yancy, Gary Bennett, Elizabeth M Strawbridge, Allison C White, Ryan J Shaw
The obesity epidemic has negative physical, psychological, and financial consequences. Despite the existence of effective behavioral weight loss interventions, many individuals do not achieve adequate weight loss, and most regain lost weight in the year following intervention. We report the rationale and design for a 2×2 factorial study that involves financial incentives for dietary self-monitoring (yes vs. no) and/or interim weight loss (yes vs. no). Outpatients with obesity participate in a 24-week, group-based weight loss intervention...
February 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29237794/recommendations-of-the-global-multiple-system-atrophy-research-roadmap-meeting
#11
REVIEW
Ryan R Walsh, Florian Krismer, Wendy R Galpern, Gregor K Wenning, Phillip A Low, Glenda Halliday, Walter J Koroshetz, Janice Holton, Niall P Quinn, Olivier Rascol, Leslie M Shaw, David Eidelberg, Pam Bower, Jeffrey L Cummings, Victor Abler, Judy Biedenharn, Gal Bitan, David J Brooks, Patrik Brundin, Hubert Fernandez, Philip Fortier, Roy Freeman, Thomas Gasser, Art Hewitt, Günter U Höglinger, Matt J Huentelman, Poul H Jensen, Andreas Jeromin, Un Jung Kang, Horacio Kaufmann, Lawrence Kellerman, Vikram Khurana, Thomas Klockgether, Woojin Scott Kim, Carol Langer, Peter LeWitt, Eliezer Masliah, Wassilios Meissner, Ronald Melki, Susanne Ostrowitzki, Steven Piantadosi, Werner Poewe, David Robertson, Cyndi Roemer, Dale Schenk, Michael Schlossmacher, Jeremy D Schmahmann, Klaus Seppi, Lily Shih, Andrew Siderowf, Glenn T Stebbins, Nadia Stefanova, Shoji Tsuji, Sharon Sutton, Jing Zhang
Multiple system atrophy (MSA) is a rare neurodegenerative disorder with substantial knowledge gaps despite recent gains in basic and clinical research. In order to make further advances, concerted international collaboration is vital. In 2014, an international meeting involving leaders in the field and MSA advocacy groups was convened in Las Vegas, Nevada, to identify critical research areas where consensus and progress was needed to improve understanding, diagnosis, and treatment of the disease. Eight topic areas were defined: pathogenesis, preclinical modeling, target identification, endophenotyping, clinical measures, imaging biomarkers, nonimaging biomarkers, treatments/trial designs, and patient advocacy...
January 9, 2018: Neurology
https://www.readbyqxmd.com/read/29233916/aging-impairs-both-primary-and-secondary-rig-i-signaling-for-interferon-induction-in-human-monocytes
#12
Ryan D Molony, Jenny T Nguyen, Yong Kong, Ruth R Montgomery, Albert C Shaw, Akiko Iwasaki
Adults older than 65 account for most of the deaths caused by respiratory influenza A virus (IAV) infections, but the underlying mechanisms for this susceptibility are poorly understood. IAV RNA is detected by the cytosolic sensor retinoic acid-inducible gene I (RIG-I), which induces the production of type I interferons (IFNs) that curtail the spread of the virus and promote the elimination of infected cells. We have previously identified a marked defect in the IAV-inducible secretion of type I IFNs, but not proinflammatory cytokines, in monocytes from older (>65 years) healthy human donors...
December 12, 2017: Science Signaling
https://www.readbyqxmd.com/read/29206318/automated-quality-assessment-of-structural-magnetic-resonance-images-in-children-comparison-with-visual-inspection-and-surface-based-reconstruction
#13
Tonya White, Philip R Jansen, Ryan L Muetzel, Gustavo Sudre, Hanan El Marroun, Henning Tiemeier, Anqi Qiu, Philip Shaw, Andrew M Michael, Frank C Verhulst
Motion-related artifacts are one of the major challenges associated with pediatric neuroimaging. Recent studies have shown a relationship between visual quality ratings of T1 images and cortical reconstruction measures. Automated algorithms offer more precision in quantifying movement-related artifacts compared to visual inspection. Thus, the goal of this study was to test three different automated quality assessment algorithms for structural MRI scans. The three algorithms included a Fourier-, integral-, and a gradient-based approach which were run on raw T1 -weighted imaging data collected from four different scanners...
March 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29171321/changes-in-medical-student-implicit-attitudes-following-a-health-equity-curricular-intervention
#14
Katie F Leslie, Susan Sawning, M Ann Shaw, Leslee J Martin, Ryan C Simpson, Jennifer E Stephens, V Faye Jones
PURPOSE: This study assessed the: (1) effect of an LGBTQI + health equity curriculum (eQuality) on implicit attitudes among first (M1) and second year (M2) medical students and (2) utility of dedicated time to explore implicit bias. METHOD: Implicit biases were assessed at baseline using implicit association tests (IAT) for all M2s and a random sample of first years (M1A). These students were then debriefed on strategies to mitigate bias. Following eQuality, all M1 and M2s completed post-intervention IATs...
November 24, 2017: Medical Teacher
https://www.readbyqxmd.com/read/29134039/monogenea-of-fishes-from-the-lagoon-flats-of-palmyra-atoll-in-the-central-pacific
#15
Víctor Manuel Vidal-Martínez, Lilia Catherinne Soler-Jiménez, Ma Leopoldina Aguirre-Macedo, John Mclaughlin, Alejandra G Jaramillo, Jenny C Shaw, Anna James, Ryan F Hechinger, Armand M Kuris, Kevin D Lafferty
A survey of the monogeneans of fishes from the lagoon flats of Palmyra Atoll detected 16 species already reported from the Indo-West Pacific faunal region. A total of 653 individual fish from 44 species were collected from the sand flats bordering the lagoon of the atoll. Eighteen species of fish were infected with monogeneans. The monogenean species recovered were: Benedenia hawaiiensis on Acanthurus xanthopterus , Chaetodon auriga , Chaetodon lunula , Mulloidichthys flavolineatus , Pseudobalistes flavimarginatus and Rhinecanthus aculeatus ; Ancyrocephalus ornatus on Arothron hispidus ; Euryhaliotrema annulocirrus on Chaetodon auriga and Chaetodon lunula ; Euryhaliotrema chrysotaeniae on Lutjanus fulvus ; Euryhaliotrema grandis on Chaetodon auriga and Chaetodon lunula ; Haliotrema acanthuri on Acanthurus triostegus ; Haliotrema aurigae on Chaetodon auriga and Chaetodon lunula ; Haliotrema dempsteri on Acanthurus xanthopterus ; Haliotrema minutospirale on Mulloidichthys flavolineatus ; Haliotrematoides patellacirrus on Lutjanus monostigma ; Neohaliotrema bombini on Abudefduf septemfasciatus and Abudefduf sordidus ; Acleotrema girellae and Acleotrema parastromatei on Kyphosus cinerascens ; Cemocotylella elongata on Caranx ignobilis , Caranx melampygus and Caranx papuensis ; Metamicrocotyla macracantha on Crenimugil crenilabris ; and Pseudopterinotrema albulae on Albula glossodonta ...
2017: ZooKeys
https://www.readbyqxmd.com/read/29055969/asymmetry-in-the-cortical-and-trabecular-bone-of-the-human-humerus-during-development
#16
Bernadette Perchalski, Arielle Placke, Simone M Sukhdeo, Colin N Shaw, James H Gosman, David A Raichlen, Timothy M Ryan
Many studies have noted that the bones of the human upper limb display bilateral asymmetry, commonly linking this asymmetry in external and internal morphology to handedness and lateralization. Few studies, however, have attempted to track asymmetry throughout ontogeny. This study assesses the ontogenetic development of cortical and trabecular bone asymmetry in the humerus. We predict that directional asymmetry in structural properties will emerge in concert with hand preference and increased activity levels during the juvenile period...
October 22, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29034821/abstracts-and-workshops-7th-national-spinal-cord-injury-conference-november-9-11-2017-fallsview-casino-resort-niagara-falls-ontario-canada
#17
Mir Hatef Shojaei, Mohammad Alavinia, B Catharine Craven, Christiana L Cheng, Tova Plashkes, Tian Shen, Nader Fallah, Suzanne Humphreys, Colleen O'Connell, Angelo Gary Linassi, Chester Ho, Christine Short, Karen Ethans, Rebecca Charbonneau, Jerome Paquet, Vanessa K Noonan, Julio C Furlan, Michael G Fehlings, B Catharine Craven, Jirapat Likitlersuang, Elizabeth Sumitro, Sukhvinder Kalsi-Ryan, José Zariffa, Dalton Wolfe, Stephanie Cornell, Julie Gagliardi, Stephanie Marrocco, Carly S Rivers, Nader Nader Fallah, Vanessa K Noonan, David Whitehurst, Carolyn Schwartz, Joel Finkelstein, B Catharine Craven, Karen Ethans, Colleen O'Connell, Catherine Truchon, Chester Ho, A Gary Linassi, Christine Short, Eve Tsai, Brian Drew, Henry Ahn, Marcel F Dvorak, Jérôme Paquet, Michael G Fehlings, Luc Noreau, Katie Lenz, K Alysse Bailey, David Allison, David Ditor, Justine Baron, Jennifer Tomasone, Dorothyann Curran, Toba Miller, Jeremy Grimshaw, Bastien Moineau, Milad Alizadeh-Meghrazi, Gabriel Stefan, Kei Masani, Milos R Popovic, Elizabeth Sumitro, Jirapat Likitlersuang, Sukhvinder Kalsi-Ryan, José Zariffa, Martha G Garcia-Garcia, Cesar Marquez-Chin, Milos R Popovic, Julio C Furlan, Sivakumar Gulasingam, B Catharine Craven, Julio C Furlan, Sivakumar Gulasingam, B Catharine Craven, Alia Khan, Clara Pujol, Mark Laylor, Nikola Unic, Maureen Pakosh, Kristin Musselman, Louise M Brisbois, B Catharine Craven, Mary C Verrier, Maryleen K Jones, Roberta O'Shea, Sakina Valika, Kaila Holtz, Elena Szefer, Vanessa Noonan, Brian Kwon, Patricia Mills, Cynthia Morin, Anne Harris, Christiana Cheng, Arlene Aspinall, Tova Plashkes, Vanessa K Noonan, Katherine Chan, Mary C Verrier, B Catharine Craven, Chris Alappat, Heather M Flett, Julio C Furlan, Kristin E Musselman, James Milligan, Loretta M Hillier, Craig Bauman, Lindsay Donaldson, Joseph Lee, James Milligan, Joseph Lee, Loretta M Hillier, Karen Slonim, Dalton Wolfe, Lindsay Sleeth, Samantha Jeske, Anna Kras-Dupuis, Stephanie Marrocco, Samantha McRae, Heather Flett, Jennifer Mokry, Joanne Zee, Mark Bayley, Jean-Francois Lemay, Audrey Roy, H Dany Gagnon, Maryleen K Jones, Roberta O'Shea, Renee Theiss, Heather Flett, Kristina Guy, Gillian Johnston, Melanie Kokotow, Sandra Mills, Jennifer Mokry, Patricia Bain, Carol Scovil, Pamela Houghton, Deena Lala, Lyndsay Orr, Paul Holyoke, Dalton Wolfe, Lyndsay Orr, Jillian Brooke, Paul Holyoke, Deena Lala, Pamela Houghton, Kathleen A Martin Ginis, Robert B Shaw, Matthew J Stork, Christopher B McBride, Julio C Furlan, B Catharine Craven, Lora Giangregorio, Sander Hitzig, Naaz Kapadia, Milos R Popovic, Vera Zivanovic, Taufik Valiante, Milos R Popovic, Eleni Patsakos, Louise Brisbois, Farnoosh Farahani, Anita Kaiser, B Catharine Craven, Eleni Patsakos, Anita Kaiser, Louise Brisbois, Farnoosh Farahani, B Catharine Craven, Ben Mortenson, Megan MacGillivray, Sadeghi Mahsa, Jared Adams, Bonita Sawatzky, Patricia Mills, Kelly Arbour-Nicitopoulos, Rebecca Bassett-Gunter, Jennifer Leo, Ritu Sharma, Amy Latimer-Cheung, Timothy Olds, Kathleen Martin Ginis, Marnie Graco, Susan Cross, Chinnaya Thiyagarajan, Shirin Shafazand, Najib Ayas, Rachel Schembri, Lauren Booker, Carmel Nicholls, Patricia Burns, Mark Nash, Sally Green, David J Berlowitz, Samantha Taran, Meredith Rocchi, Kathleen A Martin Ginis, Shane N Sweet, Jeffrey G Caron, Shane N Sweet, Meredith A Rocchi, Walter Zelaya, Shane N Sweet, Austin J Bergquist, Mikael F Del Castillo-Valenzuela, Milos R Popovic, Kei Masani, Karen Ethans, Alan Casey, Micheal Namaka, Dimitri Krassiokov-Enns, Cesar Marquez-Chin, Aaron Marquis, Naaz Desai, Vera Zivanovic, Debbie Hebert, Milos R Popovic, Julio C Furlan, B Catharine Craven, Jonathan McLeod, Audrey Hicks, Cindy Gauthier, Jasmine Arel, Rachel Brosseau, Audrey L Hicks, Dany H Gagnon, Nasrin Nejatbakhsh, Anita Kaiser, Sander L Hitzig, Shauna Cappe, Colleen McGillivray, Hardeep Singh, Jaya Sam, Heather Flett, B Catharine Craven, Mary Verrier, Kristin Musselman, Ryan G L Koh, Purbasha Garai, José Zariffa, Janelle Unger, Alison R Oates, Tarun Arora, Kristin Musselman, Bondi Moshe, Burns Anthony, Sivakumar Gulasingam, B Catharine Craven, Emilie Michalovic, Heather L Gainforth, Justine Baron, Ian D Graham, Shane N Sweet, Brian Chan, B Catharine Craven, Walter Wodchis, Suzanne Cadarette, Murray Krahn, Nicole Mittmann, Keryn Chemtob, Meredith A Rocchi, Kelly Arbour-Nicitopoulos, Dahlia Kairy, Shane N Sweet, Parisa Sabetian, Ryan G L Koh, José Zariffa, Paul Yoo, Stephanie N Iwasa, Robart Babona-Pilipos, Patrick Schneider, Prashanth Velayudhan, Umalkhair Ahmed, Milos R Popovic, Cindi M Morshead, Jaeeun Yoo, Masahiro Shinya, Matija Milosevic, Kei Masani, Sharon Gabison, Sunita Mathur, Ethne Nussbaum, Milos Popovic, Mary C Verrier, Kristin Musselman, Jean-François Lemay, Shane McCullum, Kristina Guy, Kristen Walden, Jose Zariffa, Sukhvinder Kalsi-Ryan, Milad Alizadeh-Meghrazi, Joseph Lee, James Milligan, Matt Smith, Peter Athanasopoulos, Tara Jeji, Jennifer Howcroft, Jeremy Howcroft, Andrea Townson, Rhonda Willms, Tova Plashkes, Sandra Mills, Heather Flett, Carol Scovil, Filomena Mazzella, Helen Morris, Anellina Ventre, Eldon Loh, Stacey Guy, John Kramer, Tara Jeji, Nancy Xia, Swati Mehta, Kathleen A Martin Ginis, Christopher B McBride, Robert B Shaw, Christopher West, Karen Ethans, Colleen O'Connell, Susan Charlifue, Dany H Gagnon, Manuel Jose Escalona Castillo, Martin Vermette, Lívia Pinheiro Carvalho, Antony Karelis, Dahlia Kairy, Mylène Aubertin-Leheudre, Cyril Duclos, Pamela E Houghton, Lyndsay Orr, Paul Holyoke, Anna Kras-Dupuis, Dalton Wolfe, Barry Munro, Michelle Sweeny, B Catharine Craven, Heather Flett, Sander Hitzig, Farnoosh Farahani, S Mohammad Alavinia, Maryam Omidvar, Mark Bayley, Shane N Sweet, Julie Gassaway, Rob Shaw, Minna Hong, Sarah Everhart-Skeels, Bethlyn Houlihan, Anthony Burns, Gerald Bilsky, Indira Lanig, Marnie Graco, Susan Cross, Chinnaya Thiyagarajan, Shirin Shafazand, Najib Ayas, Rachel Schembri, Lauren Booker, Carmel Nicholls, Patricia Burns, Mark Nash, Sally Green, David Berlowitz, Julio C Furlan, Sukhvinder Kalsi-Ryan
No abstract text is available yet for this article.
November 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28947949/correction-to-discovery-of-fevipiprant-nvp-qaw039-a-potent-and-selective-dp2-receptor-antagonist-for-treatment-of-asthma
#18
David A Sandham, Lucy Barker, Lyndon Brown, Zarin Brown, David Budd, Steven J Charlton, Devnandan Chatterjee, Brian Cox, Gerald Dubois, Nicholas Duggan, Edward Hall, Julia Hatto, Catherine Leblanc, Janet Maas, Jodie Manini, Rachael Profit, Darren Riddy, Catherine Ritchie, Bindi Sohal, Duncan Shaw, Rowan Stringer, David A Sykes, Matthew Thomas, Katharine L Turner, Simon J Watson, Ryan West, Elisabeth Willard, Gareth Williams, Jennifer Willis
[This corrects the article DOI: 10.1021/acsmedchemlett.7b00157.].
September 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28928340/a-first-step-in-addressing-medical-education-curriculum-gaps-in-lesbian-gay-bisexual-and-transgender-related-content-the-university-of-louisville-lesbian-gay-bisexual-and-transgender-health-certificate-program
#19
Susan Sawning, Stacie Steinbock, Rachel Croley, Ryan Combs, Ann Shaw, Toni Ganzel
BACKGROUND: Individuals who are lesbian, gay, bisexual, transgender (LGBT), gender nonconforming, and/or born with differences of sex development have specific health needs and significant health disparities exacerbated by a lack of training among health professionals. The University of Louisville LGBT Health Certificate Program used an interdisciplinary approach to increase training, potentially enabling future physicians to provide quality healthcare to LGBT patients. METHODS: A pretest-post-test design was used to investigate medical students' (n = 39) attitude and knowledge outcomes after program participation...
May 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28887402/detection-of-long-repeat-expansions-from-pcr-free-whole-genome-sequence-data
#20
Egor Dolzhenko, Joke J F A van Vugt, Richard J Shaw, Mitchell A Bekritsky, Marka van Blitterswijk, Giuseppe Narzisi, Subramanian S Ajay, Vani Rajan, Bryan R Lajoie, Nathan H Johnson, Zoya Kingsbury, Sean J Humphray, Raymond D Schellevis, William J Brands, Matt Baker, Rosa Rademakers, Maarten Kooyman, Gijs H P Tazelaar, Michael A van Es, Russell McLaughlin, William Sproviero, Aleksey Shatunov, Ashley Jones, Ahmad Al Khleifat, Alan Pittman, Sarah Morgan, Orla Hardiman, Ammar Al-Chalabi, Chris Shaw, Bradley Smith, Edmund J Neo, Karen Morrison, Pamela J Shaw, Catherine Reeves, Lara Winterkorn, Nancy S Wexler, David E Housman, Christopher W Ng, Alina L Li, Ryan J Taft, Leonard H van den Berg, David R Bentley, Jan H Veldink, Michael A Eberle
Identifying large expansions of short tandem repeats (STRs), such as those that cause amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-genome sequencing (WGS) data. A solution to this problem is an important step toward integrating WGS into precision medicine. We developed a software tool called ExpansionHunter that, using PCR-free WGS short-read data, can genotype repeats at the locus of interest, even if the expanded repeat is larger than the read length. We applied our algorithm to WGS data from 3001 ALS patients who have been tested for the presence of the C9orf72 repeat expansion with repeat-primed PCR (RP-PCR)...
November 2017: Genome Research
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