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oral isotretinoin

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https://www.readbyqxmd.com/read/28730603/hidradenitis-suppurativa-in-children-treated-with-finasteride-a-case-series
#1
Fernando Mota, Susana Machado, Manuela Selores
BACKGROUND: Hidradenitis suppurativa (HS) is rare in childhood, with only 2% of cases in patients younger than 11 years. It is a chronic, recurrent, debilitating condition for which no universally effective treatment has been developed. We present five cases of children with HS diagnosed between the ages of 6 and 11 years. METHODS: Patients were treated with oral finasteride 1 to 5 mg/day. All had entered puberty at the time of treatment initiation. All had normal laboratory results before starting treatment...
July 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28728857/-rosacea-new-data-for-better-care
#2
B Cribier
In the last 10 years, numerous studies have been published that throw new light on rosacea, in all areas of the disease. This overview summarises all the key developments, based on the indexed bibliography appearing in Medline between 2007 and 2017. Recent epidemiological data show that the prevalence of the disease is doubtless greater than estimated hitherto (more than 10% of adults in some countries) and that we should not overlook rosacea in subjects with skin phototypes V or VI, a condition that exists on all continents...
July 17, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28697223/treatment-of-annular-elastolytic-giant-cell-granuloma-with-topical-tretinoin
#3
Aubrey Wagenseller, Cecilia Larocca, Neelam A Vashi
<p>Annular elastolytic giant cell granuloma, also known as actinic granuloma, is a rare skin condition with a chronic course that is often resistant to treatment. Literature is sparse, and only a handful of case reports are available to guide treatment decisions. Typical first line treatment options include topical and intralesional steroids, topical pimecrolimus, and cryotherapy. Resistant cases have been treated with cyclosporine, systemic steroids, antimalarials, and oral retinoids. In particular, acitretin and isotretinoin have shown success in three cases...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28692353/fractional-carbon-dioxide-co2-laser-combined-with-topical-tretinoin-for-the-treatment-of-different-forms-of-cystic-acne
#4
Carmela Pestoni Porvén, Vanessa Vieira Dos Santos, Jesus Del Pozo Losada
Nodulocystic acne is prone to scarring and difficult to treat with treatments other than oral isotretinoin. The aim of this article is to discuss the role of a single session of a fractional CO2 laser combined with a topical treatment with a tretinoin and antibiotic gel for a month as a successful treatment to improve nodulocystic acne and chronic microcystic acne. Two cases were involved: the first with nodulocystic acne lesions that persisted after oral retinoids and the second with chronic microcystic acne resistant to topical treatments...
July 10, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28689869/effects-of-oral-antibiotics-and-isotretinoin-on-the-murine-gut-microbiota
#5
Eugenia Becker, Thomas S B Schmidt, Susan Bengs, Lucy Poveda, Lennart Opitz, Kirstin Atrott, Claudia Stanzel, Luc Biedermann, Ateequr Rehman, Daniel Jonas, Christian von Mering, Gerhard Rogler, Isabelle Frey-Wagner
Inflammatory bowel disease (IBD) may develop due to an immunogenic response to commensal gut microbiota triggered by environmental factors in the genetically susceptible host. Isotretinoin, applied in the treatment of severe acne, has been variably associated with IBD, but prior treatment with antibiotics, also associated with IBD development, confounds confirmation of this association. This study investigated the effects of doxycycline, metronidazole (frequently used in the treatment of acne and IBD, respectively) and isotretinoin on murine gut (faecal) microbiota after 2 weeks of treatment and after a 4-week recovery period...
July 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28676330/trends-in-prescribing-behavior-of-systemic-agents-used-in-the-treatment-of-acne-among-dermatologists-and-nondermatologists-a-retrospective-analysis-2004-2013
#6
John S Barbieri, William D James, David J Margolis
BACKGROUND: Despite recommendations to limit the use of oral antibiotics and increasing support for hormonal agents in the treatment of acne, it is unclear whether there have been any significant changes in practice patterns. OBJECTIVE: To characterize changes in prescribing behavior for systemic agents in the treatment of acne in the United States between 2004 and 2013. METHODS: We conducted a retrospective analysis using the OptumInsight Clinformatics DataMart (Optum, Eden Prairie, MN)...
July 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28658888/oral-isotretinoin-may-improve-the-symptoms-of-chronic-rhinosinusitis
#7
Habibullah Aktaş, Can Ergin, Aziz Tunç, Süha Ertuğrul
No abstract text is available yet for this article.
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28656562/diagnosis-and-treatment-of-rosacea-fulminans-a-comprehensive-review
#8
REVIEW
Rabina K Walsh, Alyson A Endicott, Kanade Shinkai
Rosacea fulminans is a rare inflammatory condition of the central face marked by the abrupt onset of erythematous coalescing papules, pustules, nodules, and draining sinuses. Due to infrequent reporting in the literature, the pathophysiology, classification, and nomenclature of this condition remain controversial. This comprehensive review evaluated a total of 135 cases of rosacea fulminans for clinical and histopathologic features and reported treatment strategies. Patients were 91% female with an average age of onset of 31...
June 27, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28636791/isotretinoin-and-lymecycline-treatments-modify-the-skin-microbiota-in-acne
#9
Hanna-Leena Kelhälä, Velma T E Aho, Nanna Fyhrquist, Pedro A B Pereira, Minna E Kubin, Lars Paulin, Riitta Palatsi, Petri Auvinen, Kaisa Tasanen, Antti Lauerma
Oral retinoids and tetracyclines have a major role in acne treatment. Here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16S ribosomal RNA (16S rRNA) gene amplicon sequencing. Propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. Five taxa, including a Streptococcus taxon, differed significantly between the cheek samples of healthy controls and acne patients, and acne severity was positively correlated with the abundance of Propionibacterium...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28560221/successful-treatment-of-facial-papules-in-frontal-fibrosing-alopecia-with-oral-isotretinoin
#10
Rodrigo Pirmez, Bruna Duque-Estrada, Taynara Barreto, Danielle C Quintella, Tullia Cuzzi
No abstract text is available yet for this article.
May 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28542914/efficacy-and-adverse-events-of-oral-isotretinoin-for-acne-a-systematic-review
#11
REVIEW
I A Vallerand, R T Lewinson, M S Farris, C D Sibley, M L Ramien, A G M Bulloch, S B Patten
Despite many years of clinical use of isotretinoin, a comprehensive review of evidence for isotretinoin therapy in acne patients is lacking. We searched MEDLINE, EMBASE, Cochrane Central, relevant webpages and bibliographies for randomized controlled trials for acne evaluating isotretinoin vs control (placebo or other therapy). Data were extracted and summarized descriptively. Eleven trials were identified (total n=760 patients randomized), containing mostly males. Mean treatment ages ranged from 18 to 47.9 years and participants generally had moderate-severe acne...
May 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28492216/psychological-status-and-quality-of-life-in-acne-patients-treated-with-oral-isotretinoin
#12
Dubravka Šimić, Jasna Zeljko Penavić, Dragan Babić, Anita Gunarić
INTRODUCTION: The acne patients are at higher risk of acquiring depresion and anxiety, which can lead to reduced quality of life. Effective treatment of acne can reduce symptoms of anxiety and depression and significantly improve other physiological parameters and quality of life of these patients. The aim of this study was to determine the psychological status and quality of life of acne patients before, during and after the treatment with oral isotretinoin. SUBJECTS AND METHODS: The prospective study included a total of 127 patients suffering from moderate to severe form of acne...
May 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28458939/isotretinoin-as-a-possible-environmental-trigger-to-autoimmunity-in-genetically-susceptible-patients
#13
Jocelyn Nugroho, Bahareh Schweiger
Introduction. Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment. Case Report. A 16-year-old female presents with symptoms of tremors, lack of focus, sleeplessness, emotional liability, bulging eyes, loose stools, heat intolerance, and missed menstrual periods. Symptoms manifested shortly after the patient finished a course of oral isotretinoin treatment for acne...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28436531/international-inter-rater-agreement-in-scoring-acne-severity-utilizing-cloud-based-image-sharing-of-mobile-phone-photographs
#14
Negar Foolad, Jennifer N Ornelas, Ashley K Clark, Ifrah Ali, Victoria R Sharon, Luluah Al Mubarak, Andrés Lopez, Ali Alikhan, Bishr Al Dabagh, Alireza Firooz, Smita Awasthi, Yu Liu, Chin-Shang Li, Raja K Sivamani
BACKGROUND: Cloud-based image sharing technology allows facilitated sharing of images. Cloud-based image sharing technology has not been well-studied for acne assessments or treatment preferences, among international evaluators. We evaluated inter-rater variability of acne grading and treatment recommendations among an international group of dermatologists that assessed photographs. METHODS: This is a prospective, single visit photographic study to assess inter-rater agreement of acne photographs shared through an integrated mobile device, cloud-based, and HIPAA-compliant platform...
April 24, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28425139/dissecting-cellulitis-of-the-scalp-with-excellent-response-to-isotretinoin
#15
Kaitlin Marquis, Laura-Catherine Christensen, Anand Rajpara
An 18-year-old man presented for evaluation of a 1-year history of painful nodules on the scalp with associated hair loss. Physical examination revealed multiple confluent, fluctuant, boggy nodules on the scalp with overlying alopecic patches. Based on these findings, a diagnosis of dissecting cellulitis of the scalp was made and the patient was successfully treated with oral isotretinoin therapy.
July 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28362520/a-systematic-review-on-oral-isotretinoin-therapy-and-clinically-observable-wound-healing-in-acne-patients
#16
Katherine A McDonald, Amanda J Shelley, Afsaneh Alavi
The association between isotretinoin and atypical wound healing remains controversial. It is common practice to delay elective procedures for 6 to 24 months after oral isotretinoin therapy. The studies supporting common practices (SCP) recommend extending this period to include the 6 to 24 months preceding treatment. The opposing studies (challenging common practices; CCP) state that the rate of scarring in isotretinoin patients is low and that delaying elective procedures is unnecessary. These practices impact a large number of dermatology patients undergoing acne treatment...
March 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28295859/adverse-effects-of-isotretinoin-a-large-retrospective-review
#17
Piotr Brzezinski, Katarzyna Borowska, Anca Chiriac, Janusz Smigielski
Acne is a very common and disfiguring disease that affects mostly adolescents and, to some extent, adults. The objective of our study was to estimate the adverse effects after isotretinoin by treatment of 3,525 patients due to acne vulgaris in a 5-year observation. Retrospective, comparative study was carried out in Poland and Romania from January 2012 to August 2016. Inclusion criteria into this study were moderate, severe, and nodulocystic inflammatory acne vulgaris. Exclusion criteria were mild acne, pregnant, and lactating women...
March 14, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28276005/the-role-of-photodynamic-therapy-in-acne-an-evidence-based-review
#18
REVIEW
Monica Boen, Joshua Brownell, Priyanka Patel, Maria M Tsoukas
BACKGROUND: Acne vulgaris is a highly prevalent skin disorder that affects almost all adolescents and can persist into adulthood. Photodynamic therapy (PDT) is an emerging treatment for acne that involves the use of a photosensitizer in combination with a light source and oxygen. METHODS: We performed a systematic review of the literature and critically evaluated the studies. Sixty-nine clinical trials, four case reports, and two retrospective studies met the inclusion criteria, and seven of the studies were high quality...
June 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28238164/excessive-serous-retinal-detachment-during-the-use-of-isotretinoin
#19
Mehmet Citirik, Kemal Tekin
PURPOSE: To report a case unilateral excessive subretinal fluid during the use of isotretinoin. METHOD: A case report. A patient who used isotretinoin orally for nodular-cystic acne vulgaris developed concurrent unilaterally excessive subretinal fluid and serous retinal detachment. RESULTS: Fluorescein angiography did not demonstrate the leakage points throughout the subretinal fluid. Spectral-domain optical coherence tomography showed the excessive subretinal fluid and serous retinal detachment at macula...
February 25, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28168623/a-report-of-two-cases-of-solid-facial-edema-in-acne
#20
Sarah Kuhn-Régnier, Joanna Mangana, Katrin Kerl, Jivko Kamarachev, Lars E French, Antonio Cozzio, Alexander A Navarini
INTRODUCTION: Solid facial edema (SFE) is a rare complication of acne vulgaris. To examine the clinical features of acne patients with solid facial edema, and to give an overview on the outcome of previous topical and systemic treatments in the cases so far published. METHODS: We report two cases from Switzerland, both young men with initially papulopustular acne resistant to topical retinoids. RESULTS: Both cases responded to oral isotretinoin, in one case combined with oral steroids...
March 2017: Dermatology and Therapy
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