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oral isotretinoin

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https://www.readbyqxmd.com/read/29099437/isotretinoin-induced-angle-closure-and-myopic-shift
#1
Young-Myoung Park, Tae-Eun Lee
PURPOSE: To report and describe the management a rare case of transient bilateral angle closure with increased intraocular pressure (IOP) and myopic shift while on isotretinoin therapy for acne. METHODS: A 28-year-old woman presented with bilateral myopic shift, angle closure with IOP increase, and supraciliary effusion 1 week after acne therapy with isotretinoin. Two weeks after stopping isotretinoin, and treatment with topical prednisolone acetate, atropine, and fixed combination of timolol and dorzolamide, refraction, IOP returned to normal and supraciliary effusions was decreased on ultrasound biomicroscopy...
November 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29036252/efficacy-of-isotretinoin-and-acitretin-in-treatment-of-frontal-fibrosing-alopecia-retrospective-analysis-of-54-cases
#2
Adriana Rakowska, Agnieszka Gradzińska, Małgorzata Olszewska, Lidia Rudnicka
This study aimed to assess the efficacy of systemic retinoids in treating frontal fibrosing alopecia (FFA). It was based on a retrospective analysis of 54 female patients with FFA treated with: oral isotretinoin at the daily dose of 20 mg (29/54) or acitretin at the daily dose of 20 mg (11/54) or with oral finasteride 5 mg/daily (14/54). The study was conducted between 2007 and 2017. The basic of the study is the measurement of distance between the frontal hairline and the glabellar crease prior to the commencement of treatment and after 6, 12, and 24 months...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29030873/a-feasibility-study-for-a-triple-blind-randomized-controlled-trial-investigating-the-effects-of-oral-isotretinoin-on-mood-and-quality-of-life-in-patients-with-acne-vulgaris
#3
S Rea, S Tucker, V Frittelli, R Gunnarsson
Isotretinoin is used in the treatment of severe acne vulgaris (AV), but has controversially been associated with depression and suicide. Large prospective studies have failed to translate this clinically. We undertook a feasibility study to investigate the parameters of a triple-blind, randomized controlled trial (RCT) assessing the effect of oral isotretinoin on quality of life (QoL) and mood in patients with AV. Patients meeting the inclusion criteria were randomized for 2 weeks to isotretinoin or doxycycline...
October 13, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28979664/oily-skin-a-review-of-treatment-options
#4
REVIEW
Dawnielle C Endly, Richard A Miller
One of the most common dermatologic concerns is oily skin, and the demand for effective treatment options is ever apparent. This review article addresses numerous topical treatment options such as retinoids, olumacostat glasaretil, and various cosmeceutical agents. several systemic and procedural techniques that incorporate isotretinoin, spironolactone, oral contraceptives, botulinum toxin, photodynamic therapy, and lasers are reviewed as well. Each treatment option is analyzed in terms of the proposed mechanism of action, efficacy reported in the literature, and potential adverse effects...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28901534/evaluation-of-the-efficacy-and-safety-of-oral-isotretinoin-versus-topical-isotretinoin-in-the-treatment-of-plane-warts-a-randomized-open-trial
#5
Gagan J Kaur, Balvinder K Brar, Sumir Kumar, Sukhmani K Brar, Baltej Singh
BACKGROUND: Plane warts are a common therapeutic problem. Our aim was to assess the efficacy and safety of oral versus topical isotretinoin in the treatment of plane warts. METHODS: Forty patients with multiple plane warts were randomized into two groups. Group A was treated with oral isotretinoin capsules in the dose of 0.5 mg/kg/d and Group B with topical isotretinoin 0.05% in gel formulation once daily at night. Treatment was given to the patients for 3 months or until the complete clearance of lesions, whichever was earlier...
December 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28862134/adult-female-acne-treated-with-spironolactone-a-retrospective-data-review-of-70-cases
#6
Anne Isvy-Joubert, Jean-Michel Nguyen, Aurélie Gaultier, Mélanie Saint-Jean, Marie Le Moigne, Elodie Boisrobert, Amir Khammari, Brigitte Dreno
The prevalence of acne in the adult population is increasing, particularly in women. Spironolactone regulates sebaceous gland activity by blocking androgen receptor. To evaluate retrospectively the efficacy of spironolactone in women with acne. Data from 70 women of at least 20 years, treated for their acne between 2010 and 2015 with low-dose spironolactone (≤150 mg/day), were analysed. Remission was defined by the number of retentional lesions inferior or equal to five and inflammatory lesions inferior or equal to two on the face...
August 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28853175/safety-of-non-ablative-fractional-laser-for-acne-scars-within-1-month-after-treatment-with-oral-isotretinoin-a-randomized-split-face-controlled-trial
#7
Sandeep S Saluja, Matthew L Walker, Erika M Summers, Payam Tristani-Firouzi, David R Smart
BACKGROUND AND OBJECTIVE: Based on reports of poor wound healing and scarring, it is currently recommended that patients wait 6 months after completion of oral isotretinoin therapy before the safe initiation of laser treatment. Our aim was to evaluate the safety of non-ablative fractional laser (NAFL) treatment for acne scars within 1 month after isotretinoin therapy. STUDY DESIGN/METHODS: This was a randomized split-face controlled trial involving 10 patients with acne scars who had completed isotretinoin treatment...
August 29, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28833773/morbihan-disease-successful-treatment-with-slow-releasing-doxycycline-monohydrate
#8
George Chaidemenos, Zoe Apalla, Theodoros Sidiropoulos
Morbihan Disease (MD), designated so after the place of origin of the first ever reported patient by R. Degos in 1957, is a rare disorder of unknown etiology, characterized by a persistent, erythematous, non-pitting, solid edema of the middle and upper third of the face with a non-specific histology(1) . The hallmark of MD is its refractoriness to treatment, oral isotretinoin and tetracyclines being the most successful therapeutic approaches. This article is protected by copyright. All rights reserved.
August 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28791981/the-oral-adverse-effects-of-isotretinoin-treatment-in-acne-vulgaris-patients-a-prospective-case-control-study
#9
U Erdemir, G Okan, S Gungor, B Tekin, S O Yildiz, E Yildiz
BACKGROUND: Isotretinoin is the most effective therapy to treat severe acne vulgaris and its systemic adverse effects have been well documented, but little is known on dental side effects over the course of treatment. OBJECTIVES: This prospective case-control study aimed to evaluate the oral adverse effects of isotretinoin in Turkish patients with acne vulgaris; compare oral conditions between patients and normal controls; and investigate the association between salivary parameters and International Caries Detection and Assessment System (ICDAS) scores...
July 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28790988/non-antibiotic-isotretinoin-treatment-differentially-controls-propionibacterium-acnes-on-skin-of-acne-patients
#10
Angela E Ryan-Kewley, David R Williams, Neill Hepburn, Ronald A Dixon
Emergence and potential transfer of antibiotic resistance in skin microorganisms is of current concern in medicine especially in dermatology contexts where long term treatment with antibiotics is common. Remarkably, non-antibiotic therapy in the form of isotretinoin - a non-antimicrobial retinoid is effective at reducing or eradicating the anaerobe Propionibacterium acnes which is causally involved in the complex pathogenesis of Acne vulgaris. This study measured the extent of colonization of P. acnes in patients with primary cystic or severe acne from three defined skin sites in 'non-lesion' areas before, during and after treatment with isotretinoin...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28730603/hidradenitis-suppurativa-in-children-treated-with-finasteride-a-case-series
#11
Fernando Mota, Susana Machado, Manuela Selores
BACKGROUND: Hidradenitis suppurativa (HS) is rare in childhood, with only 2% of cases in patients younger than 11 years. It is a chronic, recurrent, debilitating condition for which no universally effective treatment has been developed. We present five cases of children with HS diagnosed between the ages of 6 and 11 years. METHODS: Patients were treated with oral finasteride 1 to 5 mg/day. All had entered puberty at the time of treatment initiation. All had normal laboratory results before starting treatment...
July 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28728857/-rosacea-new-data-for-better-care
#12
B Cribier
In the last 10 years, numerous studies have been published that throw new light on rosacea, in all areas of the disease. This overview summarises all the key developments, based on the indexed bibliography appearing in Medline between 2007 and 2017. Recent epidemiological data show that the prevalence of the disease is doubtless greater than estimated hitherto (more than 10% of adults in some countries) and that we should not overlook rosacea in subjects with skin phototypes V or VI, a condition that exists on all continents...
August 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28697223/treatment-of-annular-elastolytic-giant-cell-granuloma-with-topical-tretinoin
#13
Aubrey Wagenseller, Cecilia Larocca, Neelam A Vashi
<p>Annular elastolytic giant cell granuloma, also known as actinic granuloma, is a rare skin condition with a chronic course that is often resistant to treatment. Literature is sparse, and only a handful of case reports are available to guide treatment decisions. Typical first line treatment options include topical and intralesional steroids, topical pimecrolimus, and cryotherapy. Resistant cases have been treated with cyclosporine, systemic steroids, antimalarials, and oral retinoids. In particular, acitretin and isotretinoin have shown success in three cases...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28692353/fractional-carbon-dioxide-co2-laser-combined-with-topical-tretinoin-for-the-treatment-of-different-forms-of-cystic-acne
#14
Carmela Pestoni Porvén, Vanessa Vieira Dos Santos, Jesus Del Pozo Losada
Nodulocystic acne is prone to scarring and difficult to treat with treatments other than oral isotretinoin. The aim of this article is to discuss the role of a single session of a fractional carbon dioxide (CO2) laser combined with a topical treatment with a tretinoin and antibiotic gel for a month as a successful treatment to improve nodulocystic acne and chronic microcystic acne. Two cases were involved: the first with nodulocystic acne lesions that persisted after oral retinoids and the second with chronic microcystic acne resistant to topical treatments...
July 10, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28689869/effects-of-oral-antibiotics-and-isotretinoin-on-the-murine-gut-microbiota
#15
Eugenia Becker, Thomas S B Schmidt, Susan Bengs, Lucy Poveda, Lennart Opitz, Kirstin Atrott, Claudia Stanzel, Luc Biedermann, Ateequr Rehman, Daniel Jonas, Christian von Mering, Gerhard Rogler, Isabelle Frey-Wagner
Inflammatory bowel disease (IBD) may develop due to an immunogenic response to commensal gut microbiota triggered by environmental factors in the genetically susceptible host. Isotretinoin, applied in the treatment of severe acne, has been variably associated with IBD, but prior treatment with antibiotics, also associated with IBD development, confounds confirmation of this association. This study investigated the effects of doxycycline, metronidazole (frequently used in the treatment of acne and IBD, respectively) and isotretinoin on murine gut (faecal) microbiota after 2 weeks of treatment and after a 4-week recovery period...
September 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28676330/trends-in-prescribing-behavior-of-systemic-agents-used-in-the-treatment-of-acne-among-dermatologists-and-nondermatologists-a-retrospective-analysis-2004-2013
#16
John S Barbieri, William D James, David J Margolis
BACKGROUND: Despite recommendations to limit the use of oral antibiotics and increasing support for hormonal agents in the treatment of acne, it is unclear whether there have been any significant changes in practice patterns. OBJECTIVE: To characterize changes in prescribing behavior for systemic agents in the treatment of acne in the United States between 2004 and 2013. METHODS: We conducted a retrospective analysis using the OptumInsight Clinformatics DataMart (Optum, Eden Prairie, MN)...
September 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28658888/oral-isotretinoin-may-improve-the-symptoms-of-chronic-rhinosinusitis
#17
Habibullah Aktaş, Can Ergin, Aziz Tunç, Süha Ertuğrul
No abstract text is available yet for this article.
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28656562/diagnosis-and-treatment-of-rosacea-fulminans-a-comprehensive-review
#18
REVIEW
Rabina K Walsh, Alyson A Endicott, Kanade Shinkai
Rosacea fulminans is a rare inflammatory condition of the central face marked by the abrupt onset of erythematous coalescing papules, pustules, nodules, and draining sinuses. Due to infrequent reporting in the literature, the pathophysiology, classification, and nomenclature of this condition remain controversial. This comprehensive review evaluated a total of 135 cases of rosacea fulminans for clinical and histopathologic features and reported treatment strategies. Patients were 91% female with an average age of onset of 31...
June 27, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28636791/isotretinoin-and-lymecycline-treatments-modify-the-skin-microbiota-in-acne
#19
Hanna-Leena Kelhälä, Velma T E Aho, Nanna Fyhrquist, Pedro A B Pereira, Minna E Kubin, Lars Paulin, Riitta Palatsi, Petri Auvinen, Kaisa Tasanen, Antti Lauerma
Oral retinoids and tetracyclines have a major role in acne treatment. Here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16S ribosomal RNA (16S rRNA) gene amplicon sequencing. Propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. Five taxa, including a Streptococcus taxon, differed significantly between the cheek samples of healthy controls and acne patients, and acne severity was positively correlated with the abundance of Propionibacterium...
June 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28560221/successful-treatment-of-facial-papules-in-frontal-fibrosing-alopecia-with-oral-isotretinoin
#20
Rodrigo Pirmez, Bruna Duque-Estrada, Taynara Barreto, Danielle C Quintella, Tullia Cuzzi
No abstract text is available yet for this article.
May 2017: Skin Appendage Disorders
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