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JOURNAL ARTICLE
Adriana P Barriga-Moreno, Marcela Lozano-Sanchez, Rafael A Barón-Alvarez, Juan P Cordoba, Gustavo Aroca-Martinez, Daniela Dianda, Henry Gonzalez-Torres, Carlos G Musso
INTRODUCTION: Coronavirus disease 2019 (COVID-19) induces organic damage mainly through the patient's immune overreaction. Hemoperfusion (HPF) can remove inflammatory cytokines and can reduce the negative effects of cytokine storm in COVID-19. We compared the mortality rate, inflammatory response, and acute kidney injury (AKI) prevalence among patients suffering from respiratory insufficiency secondary to COVID-19 treated with and without HPF with HA330 cartridge. METHODS: Mortality rate, serum creatinine, and ferritin values were compared between patients suffering from respiratory insufficiency secondary to COVID-19 who received conventional treatment and another group of patients who additionally received four sessions of HPF with HA330...
2024: Indian Journal of Nephrology
#2
G Musso, M Zoccarato, N Gallo, M Plebani, D Basso
Antibodies against glutamic acid decarboxylase (anti-GAD) are a valuable diagnostic tool to detect severe autoimmune conditions as type 1 diabetes mellitus (T1DM) and anti-GAD related neurological disorders, having the latter more often anti-GAD concentrations in serum multiple times higher than in the former. Automated immunoassays, either with ELISA or chemiluminescent technology, are validated for diagnostic use in serum with analytical ranges suitable for T1DM diagnosis. In a patient presenting with a suspected autoimmune ataxia, anti-GAD testing on an automated chemiluminescent immunoassay (CLIA) resulted in slightly abnormal concentrations in serum (39...
April 18, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
#3
JOURNAL ARTICLE
Dalida Bivona, Carmelo Bonomo, Lorenzo Colombini, Paolo G Bonacci, Grete F Privitera, Giuseppe Caruso, Filippo Caraci, Francesco Santoro, Nicolò Musso, Dafne Bongiorno, Francesco Iannelli, Stefania Stefani
Intracellular survival and immune evasion are typical features of staphylococcal infections. USA300 is a major clone of methicillin-resistant S. aureus (MRSA), a community- and hospital-acquired pathogen capable of disseminating throughout the body and evading the immune system. Carnosine is an endogenous dipeptide characterized by antioxidant and anti-inflammatory properties acting on the peripheral (macrophages) and tissue-resident (microglia) immune system. In this work, RAW 264.7 murine macrophages were infected with the USA300 ATCC BAA-1556 S...
March 16, 2024: Antibiotics
#4
JOURNAL ARTICLE
Salvatore Princiotto, Bruno Casciaro, Alvaro G Temprano, Loana Musso, Francesca Sacchi, Maria Rosa Loffredo, Floriana Cappiello, Federica Sacco, Giammarco Raponi, Virginia Perez Fernandez, Teresa Iucci, Maria Luisa Mangoni, Mattia Mori, Sabrina Dallavalle, Claudio Pisano
Multidrug-resistant (MDR) pathogens are severely impacting our ability to successfully treat common infections. Here we report the synthesis of a panel of adarotene-related retinoids showing potent antimicrobial activity on Staphylococcus aureus strains (including multidrug-resistant ones). Fluorescence and molecular dynamic studies confirmed that the adarotene analogues were able to induce conformational changes and disfunctions to the cell membrane, perturbing the permeability of the phospholipid bilayer...
February 18, 2024: Bioorganic Chemistry
#5
Alex Domínguez-Vargas, Fanny Ariño, Diana Silva, Henry J González-Tórres, Gustavo Aroca-Martinez, Eduardo Egea, Carlos G Musso
Pregnancy-associated atypical hemolytic uremic syndrome (P-aHUS) is a rare condition characterized by microangiopathic hemolytic anemia and kidney injury from thrombotic microangiopathy. P-aHUS occurs in approximately 1 in 25,000 pregnancies and is strongly related to complement dysregulation and pregnancy-related disorders, such as preeclampsia, eclampsia, and hemolysis, elevated liver enzymes, low platelet (HELLP) syndrome, resulting in adverse perinatal and fetal outcomes. Complement dysregulation in P-aHUS is commonly attributed to genetic mutations or autoantibodies affecting complement factors, including CFH , CFI , and MCP...
January 2024: American Journal of Perinatology Reports
#6
JOURNAL ARTICLE
Zilac Espitaleta, Alex Domínguez-Vargas, Johanna Villamizar-Martínez, Martha Carrascal-Guzmán, Gustavo Guerrero-Tinoco, Diana Silva-Díaz, Richard Baquero, Claudia Pinto-Bernal, Luz González-Chaparro, Luisa Rojas-Rosas, Pilar Amado-Niño, Mariángel Castillo-Arteaga, Yeferson Alvarez-Gómez, Laura Arguello-Muñoz, William Morales-Camacho, Oscar León-Guerra, Eduardo Egea, Ricardo Galeano-Rodríguez, Ana Quintero-Gómez, Gustavo Aroca-Martínez, Carlos G Musso
Objectives. Atypical hemolytic uremic syndrome (aHUS) is a rare complement-mediated kidney disease with genetic predisposition and represents up to 10% of pediatric hemolytic uremic syndrome (HUS) cases. Few studies have evaluated aHUS in Latin American population. We studied a Colombian pediatric cohort to delineate disease presentation and outcomes. Methods. A multicenter cohort of 27 Colombian children with aHUS were included. Patients were grouped by age at onset. Clinical features were compared using analysis of variance (ANOVA) and Fisher exact tests...
2024: Global Pediatric Health
#7
REVIEW
Md Hoque, Jason Nagourney, Thomas Pawlowski, Joaquin Cantos, Gustavo Aroca-Martinez, Ivan Huespe, Carlos G Musso
Inspired by the Stewart-Figge acid-base approach, Gattinoni et al. recently introduced a new internal milieu parameter known as alactic base excess (ABE). The authors defined ABE as the sum of lactate and standard base excess. In the context of sepsis, ABE has been proposed as a valuable marker to discern between metabolic acidosis resulting from the accumulation of lactate and the retention of fixed acids, which can occur in cases of renal failure. Multiple studies have demonstrated that a negative ABE value (<-3 mmol/L) represents an early marker of renal dysfunction, and significantly correlates with higher mortality rates in septic patients...
February 10, 2024: International Urology and Nephrology
#8
JOURNAL ARTICLE
Colleen E Fortier, Antonia E Musso, Maya L Evenden, L Irina Zaharia, Janice Cooke
Mountain pine beetle (MPB; Dendroctonus ponderosae Hopkins) is a devastating forest insect pest that has killed millions of hectares of pines in western North America over the past two decades. Like other bark beetles, MPB vector ophiostomatoid fungal species that are pathogenic to host pine species. The phytopathogenicity of these fungal symbionts has sparked considerable debate regarding their role in facilitating MPB attack success. We tested the hypothesis that MPB ophiostomatoid fungal associates like Grosmannia clavigera [Robinson-Jeffrey and Davidson] Zipfel, de Beer and Wingfield contribute to overwhelming host defenses during MPB mass attack...
January 19, 2024: Molecular Plant-microbe Interactions: MPMI
#9
REVIEW
Paula Schwartz, Maria M Capotondo, Miranda Quaintenne, Guido M Musso-Enz, Gustavo Aroca-Martinez, Carlos G Musso
Obesity has received considerable attention in general medicine and nephrology over the last few years. This condition increases the risk of metabolic syndrome, diabetes mellitus, hypertension, and dyslipidemia, which are the main risk factors for developing chronic kidney disease (CKD). Kidney damage caused by obesity can be explained by many mechanisms, such as sympathetic nervous and renin-angiotensin-aldosterone systems activation, mechanical stress, hormonal unbalance, as well as inflammatory cytokines production...
May 2024: International Urology and Nephrology
#10
JOURNAL ARTICLE
Ivan A Huespe, Jorge Echeverri, Aisha Khalid, Indalecio Carboni Bisso, Carlos G Musso, Salim Surani, Vikas Bansal, Rahul Kashyap
IMPORTANCE: The scientific community debates Generative Pre-trained Transformer (GPT)-3.5's article quality, authorship merit, originality, and ethical use in scientific writing. OBJECTIVES: Assess GPT-3.5's ability to craft the background section of critical care clinical research questions compared to medical researchers with H-indices of 22 and 13. DESIGN: Observational cross-sectional study. SETTING: Researchers from 20 countries from six continents evaluated the backgrounds...
October 2023: Critical care explorations
#11
JOURNAL ARTICLE
Paolo D'Incecco, Sabrina Dallavalle, Loana Musso, Veronica Rosi, Marta Sindaco, Luisa Pellegrino
Formation of the protein crosslink di-Tyrosine was studied in PET-bottled pasteurized milk exposed to fluorescent light in a commercial display cabinet. An HPLC method with fluorescence detection was developed and intra-laboratory validated using pure di-Tyrosine synthesized on purpose. Di-Tyrosine was detected after 1-day lightening and increased up to 7 days, reaching around 250 and 320 µg/g protein in whole and partly skimmed milk, respectively. Afterward, a progressive decrease occurred. By transmission electron microscopy with specific immune gold labelling, presence of di-Tyrosine was observed for the first time on the surface of casein micelles of lightened milk...
September 26, 2023: Food Chemistry
#12
JOURNAL ARTICLE
Francesco Saraceni, Myriam Labopin, Anna M Raiola, Didier Blaise, Péter Reményi, Federica Sorà, Jiri Pavlu, Stefania Bramanti, Alessandro Busca, Ana Berceanu, Giorgia Battipaglia, Giuseppe Visani, Gerard Sociè, Gesine Bug, Caterina Micò, Giorgio La Nasa, Maurizio Musso, Attilio Olivieri, Alexandros Spyridonidis, Bipin Savani, Fabio Ciceri, Arnon Nagler, Mohamad Mohty
We conducted a registry analysis including adult acute myeloid leukemia (AML) patients in remission who had received thiotepa, busulfan, and fludarabine (TBF) or treosulfan-based (Treo) conditioning for haplo-hematopoietic stem cell transplant (HSCT) with posttransplant cyclophosphamide (PTCy) between 2010 and 2020. A total of 1123 patients met the inclusion criteria (968 received TBF and 155 received Treo). A 1:1 matched-pair analysis was performed on 142 TBF and 142 Treo patients. In the Treo group, 68% of patients received treosulfan at a dose ≥36 g/m2 and 54% of patients received a second alkylator (thiotepa or melphalan)...
October 2023: HemaSphere
#13
REVIEW
German Baez, Martin Chirio, Pedro Pisula, Enrique Seminario, Natalia Carasa, Romina Philippi, Gustavo Aroca-Martinez, Carlos G Musso
BACKGROUND: Hyponatremia (serum sodium lower than 135 mmol/L) is the most frequent electrolyte alteration diagnosed in medical practice. It has deleterious clinical effects, being an independent predictor of mortality. Malnutrition encompasses pathological states caused by both nutrients excess and deficiency, being frequently documented in chronic kidney disease patients. In addition, chronic hyponatremia promotes adiposity loss and sarcopenia, while malnutrition can induce hyponatremia...
September 13, 2023: Irish Journal of Medical Science
#14
REVIEW
Dan-Qin Sun, Giovanni Targher, Christopher D Byrne, David C Wheeler, Vincent Wai-Sun Wong, Jian-Gao Fan, Herbert Tilg, Wei-Jie Yuan, Christoph Wanner, Xin Gao, Michelle T Long, Mehmet Kanbay, Mindie H Nguyen, Sankar D Navaneethan, Yusuf Yilmaz, Yuli Huang, Rino A Gani, Pierluigi Marzuillo, Jérôme Boursier, Huijie Zhang, Chan-Young Jung, Jin Chai, Luca Valenti, George Papatheodoridis, Giovanni Musso, Yu-Jun Wong, Mohamed El-Kassas, Nahum Méndez-Sánchez, Silvia Sookoian, Michael Pavlides, Ajay Duseja, Adriaan G Holleboom, Junping Shi, Wah-Kheong Chan, Yasser Fouad, Junwei Yang, Sombat Treeprasertsuk, Helena Cortez-Pinto, Masahide Hamaguchi, Manuel Romero-Gomez, Mamun Al Mahtab, Ponsiano Ocama, Atsushi Nakajima, Chunsun Dai, Mohammed Eslam, Lai Wei, Jacob George, Ming-Hua Zheng
BACKGROUND: With the rising global prevalence of fatty liver disease related to metabolic dysfunction, the association of this common liver condition with chronic kidney disease (CKD) has become increasingly evident. In 2020, the more inclusive term metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed to replace the term non-alcoholic fatty liver disease (NAFLD). The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD...
June 1, 2023: Hepatobiliary Surgery and Nutrition
#15
JOURNAL ARTICLE
Lautaro Natali, Gabriel Luna Pizarro, Sofía Moyano, Benjamin de la Cruz-Thea, Juliana Musso, Andrea S Rópolo, Norbert Eichner, Gunter Meister, Melina M Musri, Constanza Feliziani, María C Touz
The genetically related assemblages of the intestinal protozoa parasite Giardia lamblia are morphologically indistinguishable and are often derived from specific hosts. The Giardia assemblages are separated by large genetic distances, which might account for their relevant biological and pathogenic differences. In this work, we analyzed the RNAs cargo released into exosomal-like vesicles (ElVs) by the assemblages A and B, which differentially infect humans, and the assemblage E, which infects hoofed animals...
May 31, 2023: International Journal of Molecular Sciences
#16
JOURNAL ARTICLE
Giuseppe Caruso, Claudia G Fresta, Annamaria Fidilio, Francesca Lazzara, Nicolò Musso, Vincenzo Cardaci, Filippo Drago, Filippo Caraci, Claudio Bucolo
Age-related macular degeneration (AMD) has been described as a progressive eye disease characterized by irreversible impairment of central vision, and unfortunately, an effective treatment is still not available. It is well-known that amyloid-beta (Aβ) peptide is one of the major culprits in causing neurodegeneration in Alzheimer's disease (AD). The extracellular accumulation of this peptide has also been found in drusen which lies under the retinal pigment epithelium (RPE) and represents one of the early signs of AMD pathology...
April 9, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#17
REVIEW
Ifeoma I Ulasi, Olugbenga Awobusuyi, Saurabh Nayak, Raja Ramachandran, Carlos G Musso, Santos A Depine, Gustavo Aroca-Martinez, Adaobi Uzoamaka Solarin, Macaulay Onuigbo, Valerie A Luyckx, Chinwuba K Ijoma
The burden of chronic kidney disease (CKD) has increased exponentially worldwide but more so in low- and middle-income countries. Specific risk factors in these regions expose their populations to an increased risk of CKD, such as genetic risk with APOL1 among populations of West African heritage or farmers with CKD of unknown etiology that spans various countries across several continents to immigrant/indigenous populations in both low- and high-income countries. Low- and middle-income economies also have the double burden of communicable and noncommunicable diseases, both contributing to the high prevalence of CKD...
September 2022: Seminars in Nephrology
#18
JOURNAL ARTICLE
Joaquín Cantos, Iván A Huespe, Jorge F Sinner, Eduardo M Prado, Eduardo San Roman, Nicolás Contrera Rolón, Carlos G Musso
PURPOSE: Alactic base excess (ABE) is a novel biomarker defined as the sum of lactate and standard base excess and estimates the renal capability of handling acid-base disturbances in sepsis. The objective of this study is to see if ABE is an independent predictor of mortality in septic patients with and without renal dysfunction. MATERIALS AND METHODS: We retrospectively studied 1178 patients with sepsis and septic shock. Patients were divided according to ABE values: 1) negative ABE (<-3 mmol/L); 2) neutral ABE (≥ - 3 and < 4 mmol/L); and 3) positive ABE (≥4 mmol/L)...
April 2023: Journal of Critical Care
#19
JOURNAL ARTICLE
Babak Afshin-Pour, Michael Qiu, Shahrzad Hosseini, Helen Cheyne, Kevin Ha, Molly Stewart, Jan Horsky, Rachel Aviv, Nasen Zhang, Mangala Narasimhan, John Chelico, Gabriel Musso, Negin Hajizadeh
Acute Respiratory Distress Syndrome (ARDS) is associated with high morbidity and mortality. Identification of ARDS enables lung protective strategies, quality improvement interventions, and clinical trial enrolment, but remains challenging particularly in the first 24 h of mechanical ventilation. To address this we built an algorithm capable of discriminating ARDS from other similarly presenting disorders immediately following mechanical ventilation. Specifically, a clinical team examined medical records from 1263 ICU-admitted, mechanically ventilated patients, retrospectively assigning each patient a diagnosis of "ARDS" or "non-ARDS" (e...
January 5, 2023: Intelligence-based medicine
#20
JOURNAL ARTICLE
Gustavo Aroca-Martinez, Sandra Hernandez-Agudelo, Christian Castro-Hernández, Omar Cabarcas-Barbosa, Sergio Adrián Terrasa, Henry J González-Torres, Andrés Cadena-Bonfanti, Carlos G Musso
INTRODUCTION: Frailty is a clinical syndrome characterized by a decrease in strength, resistance and body physiological condition, making the individual more vulnerable, and increasing his/her risk of dependence and death. Kidney transplant (KT) is currently the best end-stage renal disease therapeutic alternative for certain individuals. Frailty status occurs in approximately 20% of KT patients. Thus, it was evaluated if there would be any change in frailty status level in a population of adult patients on chronic HD after receiving KT...
January 7, 2023: Irish Journal of Medical Science
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