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Fausto Castagnetti, Francesco Di Raimondo, Antonio De Vivo, Antonio Spitaleri, Gabriele Gugliotta, Francesco Fabbiano, Isabella Capodanno, Donato Mannina, Marzia Salvucci, Agostino Antolino, Roberto Marasca, Maurizio Musso, Monica Crugnola, Stefana Impera, Elena Trabacchi, Caterina Musolino, Francesco Cavazzini, Giuseppe Mineo, Patrizia Tosi, Carmela Tomaselli, Michele Rizzo, Sergio Siragusa, Miriam Fogli, Riccardo Ragionieri, Alessandro Zironi, Simona Soverini, Giovanni Martinelli, Michele Cavo, Paolo Vigneri, Fabio Stagno, Gianantonio Rosti, Michele Baccarani
Chronic myeloid leukemia (CML) treatment is based on company-sponsored and academic trials testing different tyrosine kinase inhibitors (TKIs) as first-line therapy. These studies included patients selected according to many inclusion-exclusion criteria, particularly age and comorbidities, with specific treatment obligations. In daily clinical practice (real-life), inclusion-exclusion criteria do not exist and the treatment outcome does not only depend on the choice of first-line TKI, but also on second- and third-line TKIs...
October 22, 2016: American Journal of Hematology
Johannes Blümel, Didier Musso, Sebastian Teitz, Tomoyuki Miyabayashi, Klaus Boller, Barbara S Schnierle, Sally A Baylis
BACKGROUND: Zika virus (ZIKV) is an emerging mosquito-borne Flavivirus of major public health concern. The potential for ZIKV transmission by blood transfusion has been demonstrated; however, inactivation or removal of ZIKV during the manufacture of plasma-derived medicinal products has not been specifically investigated. STUDY DESIGN AND METHODS: Inactivation of ZIKV by pasteurization and solvent/detergent (S/D) treatment was investigated by spiking high-titer ZIKV stocks into human serum albumin and applying either heat or adding different mixtures of S/D reagents and assaying for infectious virus particles...
October 12, 2016: Transfusion
John H-O Pettersson, Vegard Eldholm, Stephen J Seligman, Åke Lundkvist, Andrew K Falconar, Michael W Gaunt, Didier Musso, Antoine Nougairède, Remi Charrel, Ernest A Gould, Xavier de Lamballerie
The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which includes microcephaly) and Guillain-Barré syndrome (GBS) have stimulated wide-ranging research. High densities of susceptible Aedes spp., immunologically naive human populations, global population growth with increased urbanization, and escalation of global transportation of humans and commercial goods carrying vectors and ZIKV undoubtedly enhanced the emergence of ZIKV...
October 11, 2016: MBio
A Hasan, T Wobrock, B Guse, B Langguth, M Landgrebe, P Eichhammer, E Frank, J Cordes, W Wölwer, F Musso, G Winterer, W Gaebel, G Hajak, C Ohmann, P E Verde, M Rietschel, R Ahmed, W G Honer, P Dechent, B Malchow, M F U Castro, D Dwyer, C Cabral, P M Kreuzer, T B Poeppl, T Schneider-Axmann, P Falkai, N Koutsouleris
Impaired neural plasticity may be a core pathophysiological process underlying the symptomatology of schizophrenia. Plasticity-enhancing interventions, including repetitive transcranial magnetic stimulation (rTMS), may improve difficult-to-treat symptoms; however, efficacy in large clinical trials appears limited. The high variability of rTMS-related treatment response may be related to a comparably large variation in the ability to generate plastic neural changes. The aim of the present study was to determine whether negative symptom improvement in schizophrenia patients receiving rTMS to the left dorsolateral prefrontal cortex (DLPFC) was related to rTMS-related brain volume changes...
October 11, 2016: Molecular Psychiatry
Kara M Harmatys, Anthony J Musso, Kasey J Clear, Bradley D Smith
Administration of exogenous 5-aminolevulinic acid (5-ALA) to cancerous tissue leads to intracellular production of photoactive protoporphyrin IX, a biosynthetic process that enables photodynamic therapy and fluorescence-guided surgery of cancer. Cell uptake of 5-ALA is limited by its polar structure and there is a need for non-toxic chemical additives that can enhance its cell permeation. Two zinc-bis(dipicolylamine) (ZnBDPA) compounds were evaluated for their ability to promote uptake of 5-ALA into Chinese Hamster Ovary (CHO-K1) cells and produce protoporphyrin IX...
October 7, 2016: Photochemical & Photobiological Sciences
Alice Panchaud, Manon Vouga, Didier Musso, David Baud
No abstract text is available yet for this article.
September 2016: Lancet Infectious Diseases
Giovanni Musso, Maurizio Cassader, Solomon Cohney, Franco De Michieli, Silvia Pinach, Francesca Saba, Roberto Gambino
Chronic kidney disease (CKD) is a risk factor for end-stage renal disease (ESRD) and cardiovascular disease (CVD). ESRD or CVD develop in a substantial proportion of patients with CKD receiving standard-of-care therapy, and mortality in CKD remains unchanged. These data suggest that key pathogenetic mechanisms underlying CKD progression go unaffected by current treatments. Growing evidence suggests that nonalcoholic fatty liver disease (NAFLD) and CKD share common pathogenetic mechanisms and potential therapeutic targets...
October 2016: Diabetes Care
Carlos G Musso, Paula A Enz, Edgardo Werbin
No abstract text is available yet for this article.
October 1, 2016: Archivos Argentinos de Pediatría
Jan-Hendrik Trösemeier, Didier Musso, Johannes Blümel, Julien Thézé, Oliver G Pybus, Sally A Baylis
We report here the sequence of a candidate reference strain of Zika virus (ZIKV) developed on behalf of the World Health Organization (WHO). The ZIKV reference strain is intended for use in nucleic acid amplification (NAT)-based assays for the detection and quantification of ZIKV RNA.
2016: Genome Announcements
Atul A Dhavan, Rahul D Kaduskar, Loana Musso, Leonardo Scaglioni, Piera Anna Martino, Sabrina Dallavalle
The first total synthesis of leopolic acid A, a fungal metabolite with a rare 2,3-pyrrolidinedione nucleus linked to an ureido dipeptide, was designed and carried out. Crucial steps for the strategy include a Dieckmann cyclization to obtain the 2,3-pyrrolidinedione ring and a Wittig olefination to install the polymethylene chain. An oxazolidinone-containing leopolic acid A analogue was also synthesized. The antibacterial activity showed by both compounds suggests that they could be considered as promising candidates for future developments...
2016: Beilstein Journal of Organic Chemistry
Romain Désert, Sihem Mebarki, Mireille Desille, Marie Sicard, Elise Lavergne, Stéphanie Renaud, Damien Bergeat, Laurent Sulpice, Christine Perret, Bruno Turlin, Bruno Clément, Orlando Musso
Hepatocellular carcinoma (HCC) is the 3rd cause of cancer-related death worldwide. Most cases arise in a background of chronic inflammation, extracellular matrix (ECM) remodeling, severe fibrosis and stem/progenitor cell amplification. Although HCCs are soft cellular tumors, they may contain fibrous nests within the tumor mass. Thus, the aim of this study was to explore cancer cell phenotypes in fibrous nests. Combined anatomic pathology, tissue microarray and real-time PCR analyses revealed that HCCs (n=82) containing fibrous nests were poorly differentiated, expressed Wnt pathway components and target genes, as well as markers of stem/progenitor cells, such as CD44, LGR5 and SOX9...
August 18, 2016: International Journal of Biochemistry & Cell Biology
Maureen Laroche, Jérôme Marie, Oleg Mediannikov, Lionel Almeras, Jean-Michel Berenger, Didier Musso, Didier Raoult, Philippe Parola
Ticks are hematophageous arthropods that are known to host and transmit miscellaneous pathogens including zoonotic bacteria. The aim of this study was to investigate the presence of tick-associated microorganisms in Tahiti, French Polynesia with molecular tools. A total of 658 ticks from two species including Rhipicephalus sanguineus s.l. and Rh. annulatus were collected with forceps on dogs and cattle respectively, or with a flag on pasture in several locations of Tahiti in 2013. Two Rickettsia belonging to the spotted fever group different from R...
October 2016: Ticks and Tick-borne Diseases
Giovanni Musso, Franco De Michieli, Daria Bongiovanni, Renato Parente, Luciana Framarin, Nicola Leone, Mara Berrutti, Roberto Gambino, Maurizio Cassader, Solomon Cohney, Elena Paschetta
Epidemiological data set an association between the prevalence and severity of NAFLD and the incidence and stage of chronic kidney disease(CKD); furthermore, NASH-related cirrhosis has a higher risk of renal failure, a greater necessity for simultaneous liver-kidney transplantation(SLKT) and a poorer renal outcome than cirrhosis of other etiologies even after SLKT. These data suggest NASH and CKD share common proinflammatory and profibrotic mechanisms of progression, which are incompletely targeted by current treatments...
August 10, 2016: Clinical Gastroenterology and Hepatology
F O Meenan, J Mullaney
A case of naevus lipomatosus cutaneous superficialis of Hoffman and Zurhelle (N.L.C.H.Z.) is reported.Naevus lipomatosus cutaneous superficialis is a rare type of naevus first described by Hoffman and Zurhelle (1921). The condition was reviewed by Lynch and Goltz (1958). They noted eight cases in the world literature, and described a ninth. Since then, only a few further cases have been recorded. The most recent report has been from Finley and Musso (1972) who described the first example of this condition in Australia...
December 1975: Irish Journal of Medical Science
Vincenza Barresi, Angela Trovato-Salinaro, Giorgia Spampinato, Nicolò Musso, Sergio Castorina, Enrico Rizzarelli, Daniele Filippo Condorelli
Copper homeostasis and distribution is strictly regulated by a network of transporters and intracellular chaperones encoded by a group of genes collectively known as copper homeostasis genes (CHGs). In this work, analysis of The Cancer Genome Atlas database for somatic point mutations in colorectal cancer revealed that inactivating mutations are absent or extremely rare in CHGs. Using oligonucleotide microarrays, we found a strong increase in mRNA levels of the membrane copper transporter 1 protein [CTR1; encoded by the solute carrier family 31 member 1 gene (SLC31A1 gene)] in our series of colorectal carcinoma samples...
August 2016: FEBS Open Bio
Solange M Gennari, Claudia Niemeyer, Herbert S Soares, Cesar M Musso, Glauber C C Siqueira, José L Catão-Dias, Ricardo A Dias, Jitender P Dubey
Toxoplasma gondii is a coccidian parasite that infects almost all warm-blooded animals, including birds. Abrolhos is an archipelago of five islands, located in the Atlantic Ocean, 56 nautical kilometers from the south coast of the state of Bahia, northeastern Brazil. Part of this archipelago is a National Marine Park, which is a conservation area protected by the Brazilian government. The objective of this study was to determine the occurrence of T. gondii antibodies in sera of seabird's species Sula spp. and Phaeton spp...
August 15, 2016: Veterinary Parasitology
Laura Tomasello, Rosa Musso, Giovanni Cillino, Maria Pitrone, Giuseppe Pizzolanti, Antonina Coppola, Walter Arancio, Gianluca Di Cara, Ida Pucci-Minafra, Salvatore Cillino, Carla Giordano
No abstract text is available yet for this article.
2016: Stem Cell Research & Therapy
Nunzio Cardullo, Luana Pulvirenti, Carmela Spatafora, Nicolò Musso, Vincenza Barresi, Daniele Filippo Condorelli, Corrado Tringali
The biomimetic synthesis of a small library of dihydrobenzofuran neolignanamides (the natural trans-grossamide (4) and the related compounds 21-28) has been carried out through an eco-friendly oxidative coupling reaction mediated by Trametes versicolor laccase. These products, after complete spectroscopic characterization, were evaluated for their antiproliferative activity against Caco-2 (colon carcinoma), MCF-7 (mammary adenocarcinoma), and PC-3 (prostate cancer) human cells, using an MTT bioassay. The racemic neolignamides (±)-21 and (±)-27, in being the most lipophilic in the series, were potently active, with GI50 values comparable to or even lower than that of the positive control 5-FU...
August 26, 2016: Journal of Natural Products
Wilmer E Villamil-Gómez, Alfonso J Rodríguez-Morales, Ana María Uribe-García, Edgardo González-Arismendy, Jaime E Castellanos, Eliana P Calvo, Melchor Álvarez-Mon, Didier Musso
We describe the clinical findings of a pregnant woman from Colombia with triple co-infection caused by dengue, chikungunya and Zika viruses. Weekly obstetric ultrasounds from 14.6 until 29 weeks of gestation were normal. She remains under follow-up and management according standard guidelines for management of ZIKV infected pregnant women.
August 3, 2016: International Journal of Infectious Diseases: IJID
Maria Raffaella Zocchi, Caterina Camodeca, Elisa Nuti, Armando Rossello, Roberta Venè, Francesca Tosetti, Irene Dapino, Delfina Costa, Alessandra Musso, Alessandro Poggi
Hodgkin lymphoma (HL) resistant to conventional therapies is increasing, making of interest the search for new schemes of treatment. Members of the "A Disintegrin And Metalloproteases" (ADAMs) family, mainly ADAM10 or ADAM17, have been proposed as therapeutic targets in solid tumors and some ADAMs inhibitors have been shown to exert antitumor effects. We have previously described an overexpression of ADAM10 in HL, together with increased release of NKG2D ligands (NKG2D-L) and reduced activation of effector T lymphocytes with anti-lymphoma capacity...
May 2016: Oncoimmunology
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