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https://www.readbyqxmd.com/read/28294712/frequency-and-chunking-in-derived-words-a-parametric-fmri-study
#1
Alice Blumenthal-Dramé, Volkmar Glauche, Tobias Bormann, Cornelius Weiller, Mariacristina Musso, Bernd Kortmann
In usage-based linguistic theories, the assumption that high-frequency language strings are mentally represented as unitary chunks has been invoked to account for a wide range of phenomena. However, neurocognitive evidence in support of this assumption is still lacking. In line with Gestalt psychological assumptions, we propose that a language string qualifies as a chunk if the following two conditions are simultaneously satisfied: The perception of the whole string does not involve strong activation of its individual component parts, but the component parts in isolation strongly evoke the whole...
March 15, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28242789/tm6sf2-rs58542926-variant-affects-postprandial-lipoprotein-metabolism-and-glucose-homeostasis-in-nafld-a-clue-to-the-opposite-impact-of-tm6sf2-variant-on-liver-and-cardio-metabolic-disease
#2
Giovanni Musso, Ugo Cipolla, Maurizio Cassader, Silvia Pinach, Francesca Saba, Franco De Michieli, Elena Paschetta, Daria Bongiovanni, Luciana Framarin, Nicola Leone, Mara Berrutti, Floriano Rosina, Stefania Corvisieri, Federica Molinaro, Antonio Sircana, Roberto Gambino
Mechanisms underlying the opposite effects of TM6SF2 rs58542926 C>T polymorphism on liver injury and cardio-metabolic risk in NAFLD are unclear. We assessed the impact of this polymorphism on postprandial lipoprotein metabolism, glucose homeostasis, and nutrient oxidation in NAFLD. Sixty nonobese, nondiabetic, normolipidemic biopsy-proven NAFLD patients and 60 matched controls genotyped for TM6SF2 C>T polymorphism underwent: indirect calorimetry, an oral fat tolerance test with measurement of plasma lipoprotein subfractions, adipokines, incretin GIP, and an OGTT with Minimal Model analysis of glucose homeostasis...
February 27, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28241279/thiazolidinediones-and-advanced-liver-fibrosis-in-nonalcoholic-steatohepatitis-a-meta-analysis
#3
Giovanni Musso, Maurizio Cassader, Elena Paschetta, Roberto Gambino
Importance: Nonalcoholic steatohepatitis (NASH) is projected to be the leading cause of liver transplantation by 2020. Advanced fibrosis (stage F3-F4) on liver biopsy independently predicts all-cause and liver-related mortality in NASH. There are no known efficacious treatments for advanced fibrosis related to NASH. Thiazolidinedione therapy has been extensively evaluated in NASH, and new randomized clinical trials (RCTs) of its efficacy have been completed. Objective: To synthesize the evidence about the association of thiazolidinedione therapy with advanced liver fibrosis in NASH...
February 27, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28212810/chromosomal-instability-analysis-and-regional-tumor-heterogeneity-in-colon-cancer
#4
Vincenza Barresi, Sergio Castorina, Nicolò Musso, Carmela Capizzi, Tonia Luca, Giovanna Privitera, Daniele Filippo Condorelli
Chromosomal instability (CIN) is classically defined as an increase in the rate at which numerical or structural chromosomal aberrations are acquired in a cancer cell. The number of somatic copy number abnormalities (CNAs) revealed by high resolution genomic array can be considered as a surrogate marker for CIN, but several points, related to sample processing and data analysis, need to be standardized. In this work we analyzed 51 CRC samples and matched normal mucosae by whole genome SNP arrays and compared different bioinformatics tools in order to identify broad (>25% of a chromosomal arm) and focal somatic copy number abnormalities (BCNAs and FCNAs respectively)...
January 2017: Cancer Genetics
https://www.readbyqxmd.com/read/28194799/relative-analytical-sensitivity-of-donor-nucleic-acid-amplification-technology-screening-and-diagnostic-real-time-polymerase-chain-reaction-assays-for-detection-of-zika-virus-rna
#5
Mars Stone, Marion C Lanteri, Sonia Bakkour, Xutao Deng, Susan A Galel, Jeffrey M Linnen, Jorge L Muñoz-Jordán, Robert S Lanciotti, Maria Rios, Pierre Gallian, Didier Musso, José E Levi, Ester C Sabino, Lark L Coffey, Michael P Busch
BACKGROUND: Zika virus (ZIKV) has spread rapidly in the Pacific and throughout the Americas and is associated with severe congenital and adult neurologic outcomes. Nucleic acid amplification technology (NAT) assays were developed for diagnostic applications and for blood donor screening on high-throughput NAT systems. We distributed blinded panels to compare the analytical performance of blood screening relative to diagnostic NAT assays. STUDY DESIGN AND METHODS: A 25-member, coded panel (11 half-log dilutions of a 2013 French Polynesia ZIKV isolate and 2015 Brazilian donor plasma implicated in transfusion transmission, and 3 negative controls) was sent to 11 laboratories that performed 17 assays with 2 to 12 replicates per panel member...
February 14, 2017: Transfusion
https://www.readbyqxmd.com/read/28188934/new-evidence-for-endemic-circulation-of-ross-river-virus-in-the-pacific-islands-and-the-potential-for-emergence
#6
Colleen Lau, Maite Aubry, Didier Musso, Anita Teissier, Sylvie Paulous, Philippe Desprès, Xavier de-Lamballerie, Boris Pastorino, Van-Mai Cao-Lormeau, Philip Weinstein
OBJECTIVES: An epidemic of Ross River virus (RRV) occurred in the South Pacific in 1979-1980, but RRV has not been thought to occur endemically outside Australia and Papua New Guinea. A seroprevalence study was conducted to determine whether RRV has circulated in American Samoa since 1980. METHODS: RRV ELISA IgG was performed on 200 serum samples collected in American Samoa in 2010; seroneutralization tests were performed on 60 representative samples. RESULTS: Of 196 available ELISA IgG results, 145 (74%, 95% confidence interval 67-80%) were seropositive...
February 8, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28185278/zika-virus-and-blood-transfusion-the-experience-of-french-polynesia
#7
Damien Bierlaire, Sylvie Mauguin, Julien Broult, Didier Musso
BACKGROUND: Between October 2013 and March 2014, French Polynesia experienced the largest Zika virus (ZIKV) outbreak ever described before the emergence of ZIKV in the Americas in 2015. As arbovirus transfusion-transmitted (TT) infections have been previously reported, we hypothesized that transfusion of blood products could also transmit ZIKV. STUDY DESIGN AND METHODS: Mitigation strategies to prevent ZIKV-TT infections included nonspecific measures and the implementation of a laboratory developed ZIKV-specific nucleic acid testing (NAT) assay...
February 10, 2017: Transfusion
https://www.readbyqxmd.com/read/28164306/amustaline-s-303-treatment-inactivates-high-levels-of-zika-virus-in-red-blood-cell-components
#8
Andrew Laughhunn, Felicia Santa Maria, Julien Broult, Marion C Lanteri, Adonis Stassinopoulos, Didier Musso, Maite Aubry
BACKGROUND: The potential for Zika virus (ZIKV) transmission by blood transfusion (TT) has been demonstrated in French Polynesia and Brazil. Pathogen inactivation (PI) of blood products is a proactive strategy to inactivate TT pathogens including arboviruses. Inactivation of West Nile, dengue, Zika, and chikungunya viruses was previously demonstrated by photochemical treatment with amotosalen and ultraviolet A (UVA) illumination. In this study, we evaluated ZIKV inactivation in red blood cell (RBC) components by a chemical approach that uses amustaline (S-303) and glutathione (GSH)...
February 5, 2017: Transfusion
https://www.readbyqxmd.com/read/28130740/effect-of-male-house-mouse-pheromone-components-on-behavioral-responses-of-mice-in-laboratory-and-field-experiments
#9
Antonia E Musso, Regine Gries, Huimin Zhai, Stephen Takács, Gerhard Gries
Urine of male house mice, Mus musculus, is known to have primer pheromone effects on the reproductive physiology of female mice. Urine-mediated releaser pheromone effects that trigger certain behavioral responses are much less understood, and no field studies have investigated whether urine deposits by male or female mice, or synthetic mouse pheromone, increase trap captures of mice. In field experiments, we baited traps with bedding soiled with urine and feces of caged female or male mice, and recorded captures of mice in these and in control traps containing clean bedding...
January 27, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28097835/cognitive-profiles-of-patients-with-early-detected-and-treated-congenital-hypothyroidism
#10
María L Pardo Campos, Mariel Musso, Ana Keselman, Laura Gruñeiro, Ignacio Bergadá, Ana Chiesa
INTRODUCTION: Children with congenital hypothyroidism (CH) detected by newborn screening and adequately treated may have mild cognitive deficits. OBJECTIVES">To assess the intelligence quotient of children with CH and identify the presence of specific cognitive deficits. POPULATION AND METHODS: A group of 60 children with CH detected by newborn screening, who were aged 9-10 years old and received adequate treatment since their first month of life was selected and compared to a control group of 60 children without CH in the same age range...
February 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28097833/art-as-an-instrument-to-understand-the-concept-of-death
#11
EDITORIAL
Carlos G Musso, Paula A Enz
No abstract text is available yet for this article.
February 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28074866/-mycobacterium-massilipolynesiensis-sp-nov-a-rapidly-growing-mycobacterium-of-medical-interest-related-to-mycobacterium-phlei
#12
M Phelippeau, S Asmar, D Aboubaker Osman, M Sassi, C Robert, C Michelle, D Musso, M Drancourt
In French Polynesia, respiratory tract clinical isolate M26, displayed unusual phenotype and contradictory phylogenetic affiliations, suggesting a hitherto unidentified rapidly-growing Mycobacterium species. The phenotype of strain M26 was further characterized and its genome sequenced. Strain M26 genome consists in a 5,732,017-bp circular chromosome with a G + C% of 67.54%, comprising 5,500 protein-coding genes and 52 RNA genes (including two copies of the 16 S rRNA gene). One region coding for a putative prophage was also predicted...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039807/towards-highly-stable-aqueous-dispersions-of-multi-walled-carbon-nanotubes-the-effect-of-oxygen-plasma-functionalization
#13
Marta Garzia Trulli, Eloisa Sardella, Fabio Palumbo, Gerardo Palazzo, Lorena Carla Giannossa, Annarosa Mangone, Roberto Comparelli, Simone Musso, Pietro Favia
In order to improve the dispersion of multi-walled carbon nanotubes (MWCNTs) in aqueous media, their surface functionalization was carried out in O2-fed low-pressure plasmas. Differently from what can be found in the literature of this field, homogeneous functionalization was achieved by generating the plasma inside vials containing the nanotube powders properly stirred. Experimental parameters, such as input power, treatment time and pressure, were varied to investigate their influence on the process efficiency...
April 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28035622/the-huge-formula-hematocrit-urea-gender-for-screening-for-chronic-kidney-disease-in-elderly-patients-a-study-of-diagnostic-accuracy
#14
Carlos G Musso, Eduardo de Los Rios, Manuel Vilas, Sergio Terrasa, Griselda Bratti, Federico Varela, Guillermo Rosa Diez, Jose Jauregui, Daniel Luna
Chronically reduced glomerular filtration rate (GFR) in old people does not always mean that they suffer from chronic kidney disease (CKD) since their GFR can just be reduced by aging. The HUGE equation has been recently described and validated in Spain for screening CKD without taking into account the patient's GFR value. This equation is based on patient's hematocrit, plasma urea levels and gender. The present study documented that the HUGE equation had and acceptable performance for screening CKD in elderly Argentine patients...
April 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28029206/investigating-the-interaction-of-water-vapour-with-aminopropyl-groups-on-the-surface-of-mesoporous-silica-nanoparticles
#15
Gloria Berlier, Geo Paul, Giorgia Elena Musso, Emanuela Bottinelli, Maurizio Cossi, Leonardo Marchese
The interaction of water molecules with the surface of hybrid silica based mesoporous materials is studied by 29Si, 1H, 13C Solid State Nuclear Magnetic Resonance (SS NMR) and infrared spectroscopy, and supported by ab initio calculations. The surface of aminopropyl grafted mesoporous silica nanoparticles (NH2-MSN) was studied in the dehydrated state and upon interaction with controlled doses of water vapour. Former investigations described the interactions between aminopropyl and residual Si-OH groups: the present study shows the presence of hydrogen bonded species (Si-OH to NH2) and weakly interacting "free" aminopropyl chains with a restricted mobility, together with a small amount of protonated NH3+ groups...
December 28, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28011584/effect-of-anisotropy-on-ventricular-vulnerability-to-unidirectional-block-and-reentry-by-single-premature-stimulation-during-normal-sinus-rhythm-in-rat-heart
#16
S Rossi, A Buccarello, P R Ershler, R L Lux, S Callegari, D Corradi, L Carnevali, A Sgoifo, M Miragoli, E Musso, E Macchi
Single high-intensity premature stimuli when applied to the ventricles during ventricular drive of an ectopic site, as in Winfree's "pinwheel experiment," usually induce reentry arrhythmias in the normal heart, while single low-intensity stimuli barely do. Yet ventricular arrhythmia vulnerability during normal sinus rhythm remains largely unexplored. With a view to define the role of anisotropy on ventricular vulnerability to unidirectional conduction block and reentry, we revisited the pinwheel experiment with reduced constraints in the in situ rat heart...
March 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27966802/zika-virus-a-new-threat-to-human-reproduction
#17
REVIEW
David Baud, Didier Musso, Manon Vouga, Marco P Alves, Nicolas Vulliemoz
Zika virus (ZIKV) was first isolated in 1947 in a rhesus monkey from the Zika forest of Uganda. Until 2007, only 14 human cases were reported. The first large human outbreak occurred in 2007 (Yap Island, Federated States of Micronesia, Pacific) followed by French Polynesia in 2013 and Brazil in 2015. The virus is mainly transmitted through Aedes mosquito bites, but sexual and post-transfusion transmissions have been reported. Symptoms include low-grade fever, maculopapular rash, conjunctivitis, myalgia, arthralgia, and asthenia...
February 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27936162/discovery-of-a-novel-isothiazolonaphthoquinone-based-small-molecule-activator-of-foxo-nuclear-cytoplasmic-shuttling
#18
Bastien Cautain, Francisco Castillo, Loana Musso, Bibiana I Ferreira, Nuria de Pedro, Lorena Rodriguez Quesada, Susana Machado, Francisca Vicente, Sabrina Dallavalle, Wolfgang Link
FOXO factors are tumour suppressor proteins commonly inactivated in human tumours by posttranslational modifications. Furthermore, genetic variation within the FOXO3a gene is consistently associated with human longevity. Therefore, the pharmacological activation of FOXO proteins is considered as an attractive therapeutic approach to treat cancer and age-related diseases. In order to identify agents capable of activating FOXOs, we tested a collection of small chemical compounds using image-based high content screening technology...
2016: PloS One
https://www.readbyqxmd.com/read/27936036/the-rs3957357c-t-snp-in-gsta1-is-associated-with-a-higher-risk-of-occurrence-of-hepatocellular-carcinoma-in-european-individuals
#19
Hanane Akhdar, Said El Shamieh, Orlando Musso, Romain Désert, Wissam Joumaa, Dominique Guyader, Caroline Aninat, Anne Corlu, Fabrice Morel
Glutathione S-transferases (GSTs) detoxify toxic molecules by conjugation with reduced glutathione and regulate cell signaling. Single nucleotide polymorphisms (SNPs) of GST genes have been suggested to affect GST functions and thus to increase the risk of human hepatocellular carcinoma (HCC). As GSTA1 is expressed in hepatocytes and the rs3957357C>T (TT) SNP is known to downregulate GSTA1 mRNA expression, the aims of this study were: (i) to explore the relationship between the TT SNP in GSTA1 and the occurrence of HCC; (ii) to measure GSTA1 mRNA expression in HCCs...
2016: PloS One
https://www.readbyqxmd.com/read/27934443/synthesis-crystal-structure-and-stability-of-cubic-li7-xla3zr2-xbixo12
#20
Reinhard Wagner, Daniel Rettenwander, Günther J Redhammer, Gerold Tippelt, Gebhard Sabathi, Maurizio E Musso, Bernhard Stanje, Martin Wilkening, Emmanuelle Suard, Georg Amthauer
Li oxide garnets are among the most promising candidates for solid-state electrolytes in novel Li ion and Li metal based battery concepts. Cubic Li7La3Zr2O12 stabilized by a partial substitution of Zr(4+) by Bi(5+) has not been the focus of research yet, despite the fact that Bi(5+) would be a cost-effective alternative to other stabilizing cations such as Nb(5+) and Ta(5+). In this study, Li7-xLa3Zr2-xBixO12 (x = 0.10, 0.20, ..., 1.00) was prepared by a low-temperature solid-state synthesis route. The samples have been characterized by a rich portfolio of techniques, including scanning electron microscopy, X-ray powder diffraction, neutron powder diffraction, Raman spectroscopy, and (7)Li NMR spectroscopy...
December 5, 2016: Inorganic Chemistry
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