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https://www.readbyqxmd.com/read/28074866/-mycobacterium-massilipolynesiensis-sp-nov-a-rapidly-growing-mycobacterium-of-medical-interest-related-to-mycobacterium-phlei
#1
M Phelippeau, S Asmar, D Aboubaker Osman, M Sassi, C Robert, C Michelle, D Musso, M Drancourt
In French Polynesia, respiratory tract clinical isolate M26, displayed unusual phenotype and contradictory phylogenetic affiliations, suggesting a hitherto unidentified rapidly-growing Mycobacterium species. The phenotype of strain M26 was further characterized and its genome sequenced. Strain M26 genome consists in a 5,732,017-bp circular chromosome with a G + C% of 67.54%, comprising 5,500 protein-coding genes and 52 RNA genes (including two copies of the 16 S rRNA gene). One region coding for a putative prophage was also predicted...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039807/towards-highly-stable-aqueous-dispersions-of-multi-walled-carbon-nanotubes-the-effect-of-oxygen-plasma-functionalization
#2
Marta Garzia Trulli, Eloisa Sardella, Fabio Palumbo, Gerardo Palazzo, Lorena Carla Giannossa, Annarosa Mangone, Roberto Comparelli, Simone Musso, Pietro Favia
In order to improve the dispersion of multi-walled carbon nanotubes (MWCNTs) in aqueous media, their surface functionalization was carried out in O2-fed low-pressure plasmas. Differently from what can be found in the literature of this field, homogeneous functionalization was achieved by generating the plasma inside vials containing the nanotube powders properly stirred. Experimental parameters, such as input power, treatment time and pressure, were varied to investigate their influence on the process efficiency...
December 19, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28035622/the-huge-formula-hematocrit-urea-gender-for-screening-for-chronic-kidney-disease-in-elderly-patients-a-study-of-diagnostic-accuracy
#3
Carlos G Musso, Eduardo de Los Rios, Manuel Vilas, Sergio Terrasa, Griselda Bratti, Federico Varela, Guillermo Rosa Diez, Jose Jauregui, Daniel Luna
Chronically reduced glomerular filtration rate (GFR) in old people does not always mean that they suffer from chronic kidney disease (CKD) since their GFR can just be reduced by aging. The HUGE equation has been recently described and validated in Spain for screening CKD without taking into account the patient's GFR value. This equation is based on patient's hematocrit, plasma urea levels and gender. The present study documented that the HUGE equation had and acceptable performance for screening CKD in elderly Argentine patients...
December 29, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/28029206/investigating-the-interaction-of-water-vapour-with-aminopropyl-groups-on-the-surface-of-mesoporous-silica-nanoparticles
#4
Gloria Berlier, Geo Paul, Giorgia Elena Musso, Emanuela Bottinelli, Maurizio Cossi, Leonardo Marchese
The interaction of water molecules with the surface of hybrid silica based mesoporous materials is studied by 29Si, 1H, 13C Solid State Nuclear Magnetic Resonance (SS NMR) and infrared spectroscopy, and supported by ab initio calculations. The surface of aminopropyl grafted mesoporous silica nanoparticles (NH2-MSN) was studied in the dehydrated state and upon interaction with controlled doses of water vapour. Former investigations described the interactions between aminopropyl and residual Si-OH groups: the present study shows the presence of hydrogen bonded species (Si-OH to NH2) and weakly interacting "free" aminopropyl chains with a restricted mobility, together with a small amount of protonated NH3+ groups...
December 28, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28011584/effect-of-anisotropy-on-ventricular-vulnerability-to-unidirectional-block-and-reentry-by-single-premature-stimulation-during-normal-sinus-rhythm-in-rat-heart
#5
Stefano Rossi, Andrea Buccarello, Philip R Ershler, Robert L Lux, Sergio Callegari, Domenico Corradi, Luca Carnevali, Andrea Sgoifo, Michele Miragoli, Ezio Musso, Emilio Macchi
Single high-intensity premature stimuli when applied to the ventricles during ventricular drive of an ectopic site, as in the Winfree's "pinwheel experiment", usually induce reentry arrhythmias in the normal heart, while single low-intensity stimuli barely do. Yet, ventricular arrhythmia vulnerability during normal sinus-rhythm remains largely unexplored. With a view to define the role of anisotropy on ventricular vulnerability to unidirectional conduction block and reentry, we revisited the pinwheel experiment with reduced constraints in the in situ rat heart...
December 23, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27966802/zika-virus-a-new-threat-to-human-reproduction
#6
REVIEW
David Baud, Didier Musso, Manon Vouga, Marco P Alves, Nicolas Vulliemoz
Zika virus (ZIKV) was first isolated in 1947 in a rhesus monkey from the Zika forest of Uganda. Until 2007, only 14 human cases were reported. The first large human outbreak occurred in 2007 (Yap Island, Federated States of Micronesia, Pacific) followed by French Polynesia in 2013 and Brazil in 2015. The virus is mainly transmitted through Aedes mosquito bites, but sexual and post-transfusion transmissions have been reported. Symptoms include low-grade fever, maculopapular rash, conjunctivitis, myalgia, arthralgia, and asthenia...
December 14, 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27936162/discovery-of-a-novel-isothiazolonaphthoquinone-based-small-molecule-activator-of-foxo-nuclear-cytoplasmic-shuttling
#7
Bastien Cautain, Francisco Castillo, Loana Musso, Bibiana I Ferreira, Nuria de Pedro, Lorena Rodriguez Quesada, Susana Machado, Francisca Vicente, Sabrina Dallavalle, Wolfgang Link
FOXO factors are tumour suppressor proteins commonly inactivated in human tumours by posttranslational modifications. Furthermore, genetic variation within the FOXO3a gene is consistently associated with human longevity. Therefore, the pharmacological activation of FOXO proteins is considered as an attractive therapeutic approach to treat cancer and age-related diseases. In order to identify agents capable of activating FOXOs, we tested a collection of small chemical compounds using image-based high content screening technology...
2016: PloS One
https://www.readbyqxmd.com/read/27936036/the-rs3957357c-t-snp-in-gsta1-is-associated-with-a-higher-risk-of-occurrence-of-hepatocellular-carcinoma-in-european-individuals
#8
Hanane Akhdar, Said El Shamieh, Orlando Musso, Romain Désert, Wissam Joumaa, Dominique Guyader, Caroline Aninat, Anne Corlu, Fabrice Morel
Glutathione S-transferases (GSTs) detoxify toxic molecules by conjugation with reduced glutathione and regulate cell signaling. Single nucleotide polymorphisms (SNPs) of GST genes have been suggested to affect GST functions and thus to increase the risk of human hepatocellular carcinoma (HCC). As GSTA1 is expressed in hepatocytes and the rs3957357C>T (TT) SNP is known to downregulate GSTA1 mRNA expression, the aims of this study were: (i) to explore the relationship between the TT SNP in GSTA1 and the occurrence of HCC; (ii) to measure GSTA1 mRNA expression in HCCs...
2016: PloS One
https://www.readbyqxmd.com/read/27934443/synthesis-crystal-structure-and-stability-of-cubic-li7-xla3zr2-xbixo12
#9
Reinhard Wagner, Daniel Rettenwander, Günther J Redhammer, Gerold Tippelt, Gebhard Sabathi, Maurizio E Musso, Bernhard Stanje, Martin Wilkening, Emmanuelle Suard, Georg Amthauer
Li oxide garnets are among the most promising candidates for solid-state electrolytes in novel Li ion and Li metal based battery concepts. Cubic Li7La3Zr2O12 stabilized by a partial substitution of Zr(4+) by Bi(5+) has not been the focus of research yet, despite the fact that Bi(5+) would be a cost-effective alternative to other stabilizing cations such as Nb(5+) and Ta(5+). In this study, Li7-xLa3Zr2-xBixO12 (x = 0.10, 0.20, ..., 1.00) was prepared by a low-temperature solid-state synthesis route. The samples have been characterized by a rich portfolio of techniques, including scanning electron microscopy, X-ray powder diffraction, neutron powder diffraction, Raman spectroscopy, and (7)Li NMR spectroscopy...
December 5, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27880988/pioglitazone-for-advanced-fibrosis-in-nash-new-evidence-new-challenges
#10
Giovanni Musso, Maurizio Cassader, Elena Paschetta, Roberto Gambino
No abstract text is available yet for this article.
November 23, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27859375/molecular-detection-of-zika-virus-in-blood-and-rna-load-determination-during-the-french-polynesian-outbreak
#11
Didier Musso, Eline Rouault, Anita Teissier, Marion C Lanteri, Karen Zisou, Julien Broult, Emilie Grange, Tu-Xuan Nhan, Maite Aubry
BACKGROUND: Zika virus (ZIKV) viremia is reported as low and transient, however, these estimates rely on limited data. We report RNA loads in sera collected from symptomatic patients during the 2013-2014 French Polynesian ZIKV outbreak. METHODS: We performed molecular detection of ZIKV RNA in sera from 747 patients presenting with suspected acute phase ZIKV infection. Among patients with confirmed infection, we analyzed the duration of viremia, assessed viral RNA loads and recorded the main clinical symptoms...
November 14, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27832453/thoughts-around-the-zika-virus-crisis
#12
REVIEW
Didier Musso, Marion C Lanteri
As a lot of reviews are available on Zika virus (ZIKV), in this short commentary, we will focus on the recent advances and gaps in knowledge regarding our understanding of ZIKV infections and on the reaction to the "ZIKV crisis."
December 2016: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/27819657/culture-of-previously-uncultured-members-of-the-human-gut-microbiota-by-culturomics
#13
Jean-Christophe Lagier, Saber Khelaifia, Maryam Tidjani Alou, Sokhna Ndongo, Niokhor Dione, Perrine Hugon, Aurelia Caputo, Frédéric Cadoret, Sory Ibrahima Traore, El Hadji Seck, Gregory Dubourg, Guillaume Durand, Gaël Mourembou, Elodie Guilhot, Amadou Togo, Sara Bellali, Dipankar Bachar, Nadim Cassir, Fadi Bittar, Jérémy Delerce, Morgane Mailhe, Davide Ricaboni, Melhem Bilen, Nicole Prisca Makaya Dangui Nieko, Ndeye Mery Dia Badiane, Camille Valles, Donia Mouelhi, Khoudia Diop, Matthieu Million, Didier Musso, Jônatas Abrahão, Esam Ibraheem Azhar, Fehmida Bibi, Muhammad Yasir, Aldiouma Diallo, Cheikh Sokhna, Felix Djossou, Véronique Vitton, Catherine Robert, Jean Marc Rolain, Bernard La Scola, Pierre-Edouard Fournier, Anthony Levasseur, Didier Raoult
Metagenomics revolutionized the understanding of the relations among the human microbiome, health and diseases, but generated a countless number of sequences that have not been assigned to a known microorganism(1). The pure culture of prokaryotes, neglected in recent decades, remains essential to elucidating the role of these organisms(2). We recently introduced microbial culturomics, a culturing approach that uses multiple culture conditions and matrix-assisted laser desorption/ionization-time of flight and 16S rRNA for identification(2)...
November 7, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27788816/symptomatic-venous-thromboembolism-and-major-bleeding-after-renal-transplantation-should-we-use-pharmacologic-thromboprophylaxis
#14
D Musso, G I Robaina, A V Figueroa Córdoba, G D Martini, R A Albertini, C Chiurchiu, A H Tabares
BACKGROUND: Venous thromboembolism (VTE) is a major health issue that may result in complications such as post-thrombotic syndrome, pulmonary hypertension, and death. Appropriate thromboprophylaxis in individuals undergoing kidney transplantation remains unclear. The aim of this study was to determine the prevalence of symptomatic VTE and major bleeding within 90 days after renal transplantation (RT). METHODS: This was a retrospective study on consecutive patients undergoing RT at Hospital Privado Córdoba, Argentina, from January 1, 2006, to December 31, 2013...
October 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27770583/a-population-based-study-of-chronic-myeloid-leukemia-patients-treated-with-imatinib-in-first-line
#15
Fausto Castagnetti, Francesco Di Raimondo, Antonio De Vivo, Antonio Spitaleri, Gabriele Gugliotta, Francesco Fabbiano, Isabella Capodanno, Donato Mannina, Marzia Salvucci, Agostino Antolino, Roberto Marasca, Maurizio Musso, Monica Crugnola, Stefana Impera, Elena Trabacchi, Caterina Musolino, Francesco Cavazzini, Giuseppe Mineo, Patrizia Tosi, Carmela Tomaselli, Michele Rizzo, Sergio Siragusa, Miriam Fogli, Riccardo Ragionieri, Alessandro Zironi, Simona Soverini, Giovanni Martinelli, Michele Cavo, Paolo Vigneri, Fabio Stagno, Gianantonio Rosti, Michele Baccarani
Chronic myeloid leukemia (CML) treatment is based on company-sponsored and academic trials testing different tyrosine kinase inhibitors (TKIs) as first-line therapy. These studies included patients selected according to many inclusion-exclusion criteria, particularly age and comorbidities, with specific treatment obligations. In daily clinical practice (real-life), inclusion-exclusion criteria do not exist, and the treatment outcome does not only depend on the choice of first-line TKI but also on second- and third-line TKIs...
January 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/27731495/inactivation-and-removal-of-zika-virus-during-manufacture-of-plasma-derived-medicinal-products
#16
Johannes Blümel, Didier Musso, Sebastian Teitz, Tomoyuki Miyabayashi, Klaus Boller, Barbara S Schnierle, Sally A Baylis
BACKGROUND: Zika virus (ZIKV) is an emerging mosquito-borne Flavivirus of major public health concern. The potential for ZIKV transmission by blood transfusion has been demonstrated; however, inactivation or removal of ZIKV during the manufacture of plasma-derived medicinal products has not been specifically investigated. STUDY DESIGN AND METHODS: Inactivation of ZIKV by pasteurization and solvent/detergent (S/D) treatment was investigated by spiking high-titer ZIKV stocks into human serum albumin and applying either heat or adding different mixtures of S/D reagents and assaying for infectious virus particles...
October 12, 2016: Transfusion
https://www.readbyqxmd.com/read/27729507/how-did-zika-virus-emerge-in-the-pacific-islands-and-latin-america
#17
John H-O Pettersson, Vegard Eldholm, Stephen J Seligman, Åke Lundkvist, Andrew K Falconar, Michael W Gaunt, Didier Musso, Antoine Nougairède, Remi Charrel, Ernest A Gould, Xavier de Lamballerie
The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which includes microcephaly) and Guillain-Barré syndrome (GBS) have stimulated wide-ranging research. High densities of susceptible Aedes spp., immunologically naive human populations, global population growth with increased urbanization, and escalation of global transportation of humans and commercial goods carrying vectors and ZIKV undoubtedly enhanced the emergence of ZIKV...
October 11, 2016: MBio
https://www.readbyqxmd.com/read/27725655/structural-brain-changes-are-associated-with-response-of-negative-symptoms-to-prefrontal-repetitive-transcranial-magnetic-stimulation-in-patients-with-schizophrenia
#18
A Hasan, T Wobrock, B Guse, B Langguth, M Landgrebe, P Eichhammer, E Frank, J Cordes, W Wölwer, F Musso, G Winterer, W Gaebel, G Hajak, C Ohmann, P E Verde, M Rietschel, R Ahmed, W G Honer, P Dechent, B Malchow, M F U Castro, D Dwyer, C Cabral, P M Kreuzer, T B Poeppl, T Schneider-Axmann, P Falkai, N Koutsouleris
Impaired neural plasticity may be a core pathophysiological process underlying the symptomatology of schizophrenia. Plasticity-enhancing interventions, including repetitive transcranial magnetic stimulation (rTMS), may improve difficult-to-treat symptoms; however, efficacy in large clinical trials appears limited. The high variability of rTMS-related treatment response may be related to a comparably large variation in the ability to generate plastic neural changes. The aim of the present study was to determine whether negative symptom improvement in schizophrenia patients receiving rTMS to the left dorsolateral prefrontal cortex (DLPFC) was related to rTMS-related brain volume changes...
October 11, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27722428/small-molecule-additive-enhances-cell-uptake-of-5-aminolevulinic-acid-and-conversion-to-protoporphyrin-ix
#19
Kara M Harmatys, Anthony J Musso, Kasey J Clear, Bradley D Smith
Administration of exogenous 5-aminolevulinic acid (5-ALA) to cancerous tissue leads to intracellular production of photoactive protoporphyrin IX, a biosynthetic process that enables photodynamic therapy and fluorescence-guided surgery of cancer. Cell uptake of 5-ALA is limited by its polar structure and there is a need for non-toxic chemical additives that can enhance its cell permeation. Two zinc-bis(dipicolylamine) (ZnBDPA) compounds were evaluated for their ability to promote uptake of 5-ALA into Chinese Hamster Ovary (CHO-K1) cells and produce protoporphyrin IX...
November 2, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27684333/an-international-registry-for-women-exposed-to-zika-virus-during-pregnancy-time-for-answers
#20
Alice Panchaud, Manon Vouga, Didier Musso, David Baud
No abstract text is available yet for this article.
September 2016: Lancet Infectious Diseases
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