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https://www.readbyqxmd.com/read/29756813/dc-resistivity-of-quantum-critical-charge-density-wave-states-from-gauge-gravity-duality
#1
Andrea Amoretti, Daniel Areán, Blaise Goutéraux, Daniele Musso
In contrast to metals with weak disorder, the resistivity of weakly pinned charge density waves (CDWs) is not controlled by irrelevant processes relaxing momentum. Instead, the leading contribution is governed by incoherent, diffusive processes which do not drag momentum and can be evaluated in the clean limit. We compute analytically the dc resistivity for a family of holographic charge density wave quantum critical phases and discuss its temperature scaling. Depending on the critical exponents, the ground state can be conducting or insulating...
April 27, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29739925/re-visiting-the-evolution-dispersal-and-epidemiology-of-zika-virus-in-asia
#2
John H-O Pettersson, Jon Bohlin, Myrielle Dupont-Rouzeyrol, Ola B Brynildsrud, Kristian Alfsnes, Van-Mai Cao-Lormeau, Michael W Gaunt, Andrew K Falconar, Xavier de Lamballerie, Vegard Eldholm, Didier Musso, Ernest A Gould
Based on serological evidence and viral isolation, Zika virus (ZIKV) has circulated for many years relatively benignly in a sylvatic cycle in Africa and an urban cycle in South East Asia (SEA). With the recent availability of limited but novel Indian ZIKV sequences to add to the plethora of SEA sequences, we traced the phylogenetic history and spatio-temporal dispersal pattern of ZIKV in Asia prior to its explosive emergence in the Pacific region and the Americas. These analyses demonstrated that the introduction and dispersal of ZIKV on the Pacific islands were preceded by an extended period of relatively silent transmission in SEA, enabling the virus to expand geographically and evolve adaptively before its unanticipated introduction to immunologically naive populations on the Pacific islands and in the Americas...
May 9, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29674704/mek-inhibitors-overcome-resistance-to-bet-inhibition-across-a-number-of-solid-and-hematologic-cancers
#3
Anastasia Wyce, Jeanne J Matteo, Shawn W Foley, Daniel J Felitsky, Satyajit R Rajapurkar, Xi-Ping Zhang, Melissa C Musso, Susan Korenchuk, Natalie O Karpinich, Kathryn M Keenan, Melissa Stern, Lijoy K Mathew, Charles F McHugh, Michael T McCabe, Peter J Tummino, Ryan G Kruger, Christopher Carpenter, Olena Barbash
BET inhibitors exhibit broad activity in cancer models, making predictive biomarkers challenging to define. Here we investigate the biomarkers of activity of the clinical BET inhibitor GSK525762 (I-BET; I-BET762) across cancer cell lines and demonstrate that KRAS mutations are novel resistance biomarkers. This finding led us to combine BET with RAS pathway inhibition using MEK inhibitors to overcome resistance, which resulted in synergistic effects on growth and survival in RAS pathway mutant models as well as a subset of cell lines lacking RAS pathway mutations...
April 20, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29651834/efficacy-of-anthropometric-measures-for-identifying-cardiovascular-disease-risk-in-adolescents-review-and-meta-analysis
#4
Michael Lichtenauer, Sean D Wheatley, Marrissa Martyn-St James, Michael J Duncan, Fernanda Cobayashi, Gabriela Berg, Carla Musso, Mabel Graffigna, Jimena Soutelo, Pascal Bovet, Anastasios Kollias, George S Stergiou, Evangelos Grammatikos, Claire Griffiths, Lee Ingle, Christian Jung
BACKGROUND: To compare the ability of body mass index (BMI), waist circumference (WC) and waist to height ratio (WHtR) to estimate cardiovascular disease (CVD) risk levels in adolescents. METHODS: A systematic review and meta-analysis was performed after a database search for relevant literature (Cochrane, Centre for Review and Dissemination, PubMed, British Nursing Index, CINAHL, BIOSIS citation index, ChildData, metaRegister). RESULTS: 117 records representing 96 studies with 994,595 participants were included in the systematic review, 14 of which (13 studies, n=14,610) were eligible for the meta-analysis...
April 12, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29621908/cost-utility-analysis-on-telemonitoring-of-users-with-pacemakers-the-poniente-study
#5
Antonio Lopez-Villegas, Daniel Catalan-Matamoros, Emilio Robles-Musso, Rafael Bautista-Mesa, Salvador Peiro
Introduction Few studies have confirmed the cost-saving of telemonitoring of users with pacemakers (PMs). The purpose of this controlled, non-randomised, non-masked clinical trial was to perform an economic assessment of telemonitoring (TM) of users with PMs and check whether TM offers a cost-utility alternative to conventional follow-up in hospital. Methods Eighty-two patients implanted with an internet-based transmission PM were selected to receive either conventional follow-up in hospital ( n = 52) or TM ( n = 30) from their homes...
January 1, 2018: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29619613/soft-tissue-sarcomas-in-the-precision-medicine-era-new-advances-in-clinical-practice-and-future-perspectives
#6
Giuseppe Badalamenti, Carlo Messina, Ida De Luca, Emmanuela Musso, Alessandra Casarin, Lorena Incorvaia
Soft tissue sarcomas (STSs) represent a rare and heterogeneous group of solid tumours derived from mesenchymal progenitors and account for 1% of all adult malignancies. Although in the last decade anthracycline-based chemotherapy single agent or in combinations has been able to improve clinical benefits, prognosis is still poor and STSs represent an important unmet medical need. Continuous advances in cancer genetics and genomics have contributed to change management paradigms of STSs as it occurred for other solid tumours...
April 4, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29615676/silent-infection-of-human-dendritic-cells-by-african-and-asian-strains-of-zika-virus
#7
Nathalie J Vielle, Beatrice Zumkehr, Obdulio García-Nicolás, Fabian Blank, Miloš Stojanov, Didier Musso, David Baud, Artur Summerfield, Marco P Alves
While Zika virus (ZIKV) circulated for decades (African lineage strains) without report of outbreaks and severe complications, its emergence in French Polynesia and subsequently in the Americas (Asian lineage strains) was associated with description of severe neurological defects in newborns/neonates and adults. With the aim to identify virus lineage-dependent factors, we compared cell susceptibility, virus replication, cell death and innate immune responses following infection with two African and three contemporary Asian lineage strains of ZIKV...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29559572/erratum-for-pettersson-et-al-how-did-zika-virus-emerge-in-the-pacific-islands-and-latin-america
#8
John H-O Pettersson, Vegard Eldholm, Stephen J Seligman, Åke Lundkvist, Andrew K Falconar, Michael W Gaunt, Didier Musso, Antoine Nougairède, Remi Charrel, Ernest A Gould, Xavier de Lamballerie
No abstract text is available yet for this article.
March 20, 2018: MBio
https://www.readbyqxmd.com/read/29557609/parenting-styles-and-coping-strategies-among-patients-with-early-detected-and-treated-congenital-hypothyroidism
#9
María L Pardo Campos, Mariel Musso, Ana Keselman, Laura Gruñeiro, Ignacio Bergadá, Ana Chiesa
INTRODUCTION: Congenital hypothyroidism (CH), as any chronic disease, has an impact on the parent-child relationship and on the child's resources to cope with conflicting situations. OBJECTIVES: To describe parenting styles according to the perception of children with CH and their coping strategies. POPULATION AND METHODS: Children aged 9-10 years who had CH detected by newborn screening and had received adequate treatment and a group without CH (control group)...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29557593/managing-uncertainty-in-medicine
#10
Carlos G Musso
No abstract text is available yet for this article.
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29549059/is-the-zika-threat-over
#11
D Musso, V M Cao-Lormeau
No abstract text is available yet for this article.
June 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29535311/publisher-correction-discordant-congenital-zika-syndrome-twins-show-differential-in-vitro-viral-susceptibility-of-neural-progenitor-cells
#12
Luiz Carlos Caires-Júnior, Ernesto Goulart, Uirá Souto Melo, Bruno Henrique Silva Araujo, Lucas Alvizi, Alessandra Soares-Schanoski, Danyllo Felipe de Oliveira, Gerson Shigeru Kobayashi, Karina Griesi-Oliveira, Camila Manso Musso, Murilo Sena Amaral, Lucas Ferreira daSilva, Renato Mancini Astray, Sandra Fernanda Suárez-Patiño, Daniella Cristina Ventini, Sérgio Gomes da Silva, Guilherme Lopes Yamamoto, Suzana Ezquina, Michel Satya Naslavsky, Kayque Alves Telles-Silva, Karina Weinmann, Vanessa van der Linden, Helio van der Linden, João Ricardo Mendes de Oliveira, Nivia Maria Rodrigues Arrais, Adriana Melo, Thalita Figueiredo, Silvana Santos, Joanna Goes Castro Meira, Saulo Duarte Passos, Roque Pacheco de Almeida, Ana Jovina Barreto Bispo, Esper Abrão Cavalheiro, Jorge Kalil, Edécio Cunha-Neto, Helder Nakaya, Robert Andreata-Santos, Luis Carlos de Souza Ferreira, Sergio Verjovski-Almeida, Paulo Lee Ho, Maria Rita Passos-Bueno, Mayana Zatz
The original PDF version of this Article contained errors in the spelling of Luiz Carlos Caires-Júnior, Uirá Souto Melo, Bruno Henrique Silva Araujo, Alessandra Soares-Schanoski, Murilo Sena Amaral, Kayque Alves Telles-Silva, Vanessa van der Linden, Helio van der Linden, João Ricardo Mendes de Oliveira, Nivia Maria Rodrigues Arrais, Joanna Goes Castro Meira, Ana Jovina Barreto Bispo, Esper Abrão Cavalheiro, and Robert Andreata-Santos, which were incorrectly given as Luiz Carlos de Caires Jr., UiráSouto Melo, Bruno Silva Henrique Araujo, Alessandra Soares Schanoski, MuriloSena Amaral, Kayque Telles Alves Silva, Vanessa Van der Linden, Helio Van der Linden, João Mendes Ricardo de Oliveira, Nivia Rodrigues Maria Arrais, Joanna Castro Goes Meira, Ana JovinaBarreto Bispo, EsperAbrão Cavalheiro, and Robert Andreata Santos...
March 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29516431/a-severe-case-of-epigastric-pain-diarrhea-and-coffee-ground-vomitus
#13
Claudia Marinucci, Federica Zardo, Alessandro Musso, Paolo Strignano, Stefania Morra di Cella, Massimo Porta
No abstract text is available yet for this article.
March 7, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29499974/specialized-proresolving-mediators-enhancing-nonalcoholic-steatohepatitis-and-fibrosis-resolution
#14
REVIEW
Giovanni Musso, Roberto Gambino, Maurizio Cassader, Elena Paschetta, Antonio Sircana
The resolution of necroinflammation and fibrosis remains a primary clinical target in nonalcoholic steatohepatitis (NASH), the most common chronic liver disease and a major cause of end-stage liver disease. Our understanding of the basic molecular mechanisms driving inflammation and fibrosis and their resolution in obesity-related conditions, including NASH, have led to the proposal of a novel, tractable therapeutic paradigm involving specialized proresolving mediators (SPMs), namely lipoxins (LXs), resolvins (Rvs), protectins (PDs), and maresins (MaRs)...
April 2018: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29460745/seroprevalence-of-dengue-and-chikungunya-virus-antibodies-french-polynesia-2014-2015
#15
Maite Aubry, Anita Teissier, Michael Huart, Sébastien Merceron, Jessica Vanhomwegen, Mihiau Mapotoeke, Teheipuaura Mariteragi-Helle, Claudine Roche, Anne-Laure Vial, Sylvianne Teururai, Sébastien Sicard, Sylvie Paulous, Philippe Desprès, Jean-Claude Manuguerra, Henri-Pierre Mallet, Allison Imrie, Didier Musso, Xavier Deparis, Van-Mai Cao-Lormeau
We investigated dengue and chikungunya virus antibody seroprevalence in French Polynesia during 2014-2015. Dengue virus seroprevalence was ≈60% among schoolchildren and >83% among the general population; chikungunya virus seroprevalence was <3% before and 76% after Zika virus emergence (2013). Dengue virus herd immunity may affect Zika virus infection and pathogenesis.
March 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29452884/water-soluble-glucose-derivative-of-thiocarbohydrazone-acts-as-ionophore-with-cytotoxic-effects-on-tumor-cells
#16
Carmela Bonaccorso, Giulia Grasso, Nicolò Musso, Vincenza Barresi, Daniele F Condorelli, Diego La Mendola, Enrico Rizzarelli
A novel water-soluble ionophore based on the thiocarbohydrazone moiety conjugated with glucose (GluTch) was synthesized through a simple two-step procedure. Structural elucidation was carried out in water solution by means of various spectroscopic techniques (NMR, UV-Vis, and CD), electrospray ionization mass spectrometry and density functional theory calculations. The flexible nature of the thiocarbohydrazone moiety of the new glycoderivative compound induced both different coordination motifs and stoichiometry towards copper and zinc...
May 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29438315/synthesis-and-evaluation-of-the-tumor-cell-growth-inhibitory-potential-of-new-putative-hsp90-inhibitors
#17
Ana Bizarro, Diana Sousa, Raquel T Lima, Loana Musso, Raffaella Cincinelli, Vantina Zuco, Michelandrea De Cesare, Sabrina Dallavalle, M Helena Vasconcelos
BACKGROUND: Heat shock protein 90 (HSP90) is a well-known target for cancer therapy. In a previous work, some of us have reported a series of 3-aryl-naphtho[2,3- d ]isoxazole-4,9-diones as inhibitors of HSP90. METHODS: In the present work, various compounds with new chromenopyridinone and thiochromenopyridinone scaffolds were synthesized as potential HSP90 inhibitors. Their binding affinity to HSP90 was studied in vitro. Selected compounds ( 5 and 8 ) were further studied in various tumor cell lines regarding their potential to cause cell growth inhibition, alter the cell cycle profile, inhibit proliferation, and induce apoptosis...
February 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29427262/factor-structure-and-clinical-correlates-of-the-61-item-wender-utah-rating-scale-wurs
#18
Matthew Calamia, Benjamin D Hill, Mandi W Musso, Russell D Pella, Wm Drew Gouvier
The objective of this study was to assess the factor structure and clinical correlates of a 61-item version of the Wender Utah Rating Scale (WURS), a self-report retrospective measure of childhood problems, experiences, and behavior used in ADHD assessment. Given the currently mostly widely used form of the WURS was derived via a criterion-keyed approach, the study aimed to use latent variable modeling of the 61-item WURS to potentially identify more and more homogeneous set of items reflecting current conceptualizations of ADHD symptoms...
February 9, 2018: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/29419433/impact-of-extramedullary-disease-in-patients-with-newly-diagnosed-multiple-myeloma-undergoing-autologous-stem-cell-transplantation-a-study-from-the-chronic-malignancies-working-party-of-the-ebmt
#19
Nico Gagelmann, Diderik-Jan Eikema, Simona Iacobelli, Linda Koster, Hareth Nahi, Anne-Marie Stoppa, Tamás Masszi, Denis Caillot, Stig Lenhoff, Miklos Udvardy, Charles Crawley, William Arcese, Clara Mariette, Ann Hunter, Xavier Leleu, Martin Schipperus, Michel Delforge, Pietro Pioltelli, John A Snowden, Maija Itälä-Remes, Maurizio Musso, Anja van Biezen, Laurent Garderet, Nicolaus Kröger
We investigated extramedullary disease in newly diagnosed multiple myeloma patients and its impact on outcome following first-line autologous stem cell transplantation. We identified 3744 adult myeloma patients who received up-front single (n=3391) or tandem transplantation (n=353) between 2005 and 2014 with available data on extramedullary involvement at diagnosis. The overall incidence of extramedullary disease was 18.2% (n=682) and increased per year from 6.5% (2005) to 23.7% (2014). Paraskeletal involvement was found in 543 (14...
May 2018: Haematologica
https://www.readbyqxmd.com/read/29396410/discordant-congenital-zika-syndrome-twins-show-differential-in-vitro-viral-susceptibility-of-neural-progenitor-cells
#20
Luiz Carlos Caires-Júnior, Ernesto Goulart, Uirá Souto Melo, Bruno Henrique Silva Araujo, Lucas Alvizi, Alessandra Soares-Schanoski, Danyllo Felipe de Oliveira, Gerson Shigeru Kobayashi, Karina Griesi-Oliveira, Camila Manso Musso, Murilo Sena Amaral, Lucas Ferreira daSilva, Renato Mancini Astray, Sandra Fernanda Suárez-Patiño, Daniella Cristina Ventini, Sérgio Gomes da Silva, Guilherme Lopes Yamamoto, Suzana Ezquina, Michel Satya Naslavsky, Kayque Alves Telles-Silva, Karina Weinmann, Vanessa van der Linden, Helio van der Linden, João Ricardo Mendes de Oliveira, Nivia Maria Rodrigues Arrais, Adriana Melo, Thalita Figueiredo, Silvana Santos, Joanna Goes Castro Meira, Saulo Duarte Passos, Roque Pacheco de Almeida, Ana Jovina Barreto Bispo, Esper Abrão Cavalheiro, Jorge Kalil, Edécio Cunha-Neto, Helder Nakaya, Robert Andreata-Santos, Luis Carlos de Souza Ferreira, Sergio Verjovski-Almeida, Paulo Lee Ho, Maria Rita Passos-Bueno, Mayana Zatz
Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the NPCs from CZS babies show a significantly different gene expression signature of mTOR and Wnt pathway regulators, key to a neurodevelopmental program. Following ZIKV in vitro infection, cells from affected individuals have significantly higher ZIKV replication and reduced cell growth...
February 2, 2018: Nature Communications
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