keyword
MENU ▼
Read by QxMD icon Read
search

HHV-8

keyword
https://www.readbyqxmd.com/read/27902590/genotypic-distribution-of-hhv-8-in-aids-individuals-without-and-with-kaposi-sarcoma-is-genotype-b-associated-with-better-prognosis-of-aids-ks
#1
Tania Regina Tozetto-Mendoza, Karim Yaqub Ibrahim, Adriana Fumie Tateno, Cristiane Mendes de Oliveira, Laura Massami Sumita, Maria Carmem Arroyo Sanchez, Expedito José Luna, Ligia Camara Pierrotti, Jan Felix Drexler, Paulo Henrique Braz-Silva, Claudio Sérgio Pannuti, Camila Malta Romano
AIDS-associated Kaposi's sarcoma (AIDS-KS) caused by human herpes virus 8 (HHV-8) is the most severe and resistant form of KS tumor. Our aim was to verify whether there is an association between HHV-8 variability and development of AIDS-KS in Brazil by comparing the HHV-8 variability between individuals without and with KS. Saliva samples and blood, when available, were analyzed by polymerase chain reaction (PCR) techniques for detection of the fragments of ORF K1 of HHV-8, which were then genotyped and analyzed regarding the genetic variability...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27894280/is-there-any-association-between-sarcoidosis-and-infectious-agents-a-systematic-review-and-meta-analysis
#2
Tiago Esteves, Gloria Aparicio, Vicente Garcia-Patos
BACKGROUND: During the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. With the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. METHODS: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement from the Cochrane collaboration guidelines...
November 28, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27872774/pulmonary-kaposi-sarcoma-an-uncommon-cause-of-respiratory-failure-in-the-era-of-highly-active-antiretroviral-therapy-case-report-and-review-of-the-literature
#3
Stanley M Nwabudike, Stefan Hemmings, Yonette Paul, Yordanis Habtegebriel, Octavius Polk, Alem Mehari
Kaposi Sarcoma (KS) is the most common malignancy associated with Acquired Immune Deficiency Syndrome (AIDS) and is caused by Human Herpesvirus 8 (HHV 8) or Kaposi Sarcoma Herpesvirus (KSHV). In about 90% of cases Kaposi Sarcoma is associated with cutaneous lesions; however visceral disease can occur in the absence of cutaneous involvement. In the era of Highly Active Antiretroviral Therapy (HAART), the incidence of KS has declined. Clinical features of pulmonary KS might be difficult to distinguish from pneumonia in the immunocompromised patients and could lead to diagnostic challenges...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27812258/presentation-and-outcome-of-castleman-s-disease-in-immunocompetent-hosts
#4
Gaurav Prakash, Amanjeet Bal, Pankaj Malhotra, Vaishali Aggarwal, Alka Khadwal, Vikas Suri, Sanjay Jain, Savita Kumari, Radhika Srinivasan, Ashim Das, Neelam Varma, Subhash Varma
Castleman's disease (CD) is a heterogeneous lymphoproliferative disorder of unknown aetiology. Mostly, this disorder is seen in immunocompromised hosts. It is known to be associated with systemic disorders like HIV, HHV-8, lymphoma, and Kaposi sarcoma. As of today, the clinical behaviour and outcome of CD in immunocompetent host remains suboptimally studied. We analyzed consecutively treated cases of CD presented to our centre in last 12 years. Case record files were studied for patient's characteristics, clinical presentation, baseline laboratory and pathologic parameters, therapy and outcome...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27790727/durable-remission-of-both-multicentric-castleman-s-disease-and-kaposi-s-sarcoma-with-valganciclovir-rituximab-and-liposomal-doxorubicin-in-an-hhv-8-positive-hiv-negative-patient
#5
C Murphy, E Hawkes, F Chionh, G Chong
WHAT IS KNOWN AND OBJECTIVE: Human herpesvirus-8 (HHV-8)-positive, HIV-negative multicentric Castleman's disease is a rare lymphoproliferative disorder with no standardized treatment. Concurrent Kaposi's sarcoma, another HHV-8-related disease, is uncommon in HIV-negative patients. The role of antiviral therapy and rituximab in HIV-negative patients is not well established. CASE DESCRIPTION: We report a case of a 5-year, durable remission of HHV-8-positive, HIV-negative comorbid multicentric Castleman's disease and Kaposi's sarcoma treated with long-term valganciclovir, following initial rituximab and liposomal doxorubicin...
October 28, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27777802/tafro-syndrome-associated-with-ebv-and-successful-triple-therapy-treatment-case-report-and-review-of-the-literature
#6
Malorie Simons, Emmanuel Apor, James N Butera, Diana O Treaba
TAFRO syndrome is a rare constellation of symptoms: thrombocytopenia, anasarca, reticulin fibrosis of the bone marrow, renal dysfunction, and organomegaly. Its pathogenesis involves an excessive and inappropriate cytokine storm, most notably from IL-6, causing multiorgan failure; however, its etiology is undetermined. Starting in 2012, TAFRO syndrome was first identified in Japan as an atypical variant of Castleman's disease. Previous reports include various different treatment protocols with inconsistent survival outcomes...
2016: Case Reports in Hematology
https://www.readbyqxmd.com/read/27772621/oncogenic-%C3%AE-herpesviruses-ebv-and-hhv8-in-kidney-transplantation
#7
Jade Le
Epstein-Barr virus (EBV) and human herpesvirus-8 (HHV-8) are γ herpesviruses associated with post-transplant malignancies in kidney transplant recipients. EBV is associated with post-transplantation lymphoproliferative disorder (PTLD), with increased risk in EBV-seronegative patients on intensified immunosuppression. Human herpesvirus-8 is associated with Kaposi's sarcoma (KS), with an increased risk in certain patient populations. Diagnosis of PTLD and KS relies on tissue biopsy. The mainstay of therapy for both PTLD and Kaposi's sarcoma is a reduction of immunosuppression, and in the case of PTLD, consideration of rituximab...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27771992/castleman-s-disease-of-the-spleen
#8
D Mantas, C Damaskos, P Dailiani, M Samarkos, P Korkolopoulou
INTRODUCTION: Castleman's disease (CD), also known as giant or angiofolicular lymphoid hyperplasia or lymphoid hamartoma, is a group of atypical lymphoproliferative disorders that share common lymph node histological features and may be localized either to a single lymph node (unicentric) or occur systemically (multicentric). PATIENT AND METHOD: Herein, we present a rare case of a of 75-year-old female patient who was referred to our department and after a thorough work-up, underwent splenectomy with synchronous resection of an accessory spleen, splenic artery lymph nodes, and splenic hilar lymph nodes due to splenic involvement in a multicentric CD...
October 24, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27650622/morphoproteomics-identifies-etiopathogenetic-correlates-of-hhv-8-associated-kaposi-s-sarcoma-and-provides-pathways-with-therapeutic-options-a-case-study
#9
Suhair Al Salihi, Jamie Buryanek, Adan A Rios, Robert E Brown
A morphoproteomic analysis was performed to identify the proteins and corresponding molecular pathways activated for a case of non-HIV Kaposi's sarcoma. This analysis provides insight into the biology of the tumor and identifies etiopathogenetic correlates of HHV-8-Associated Kaposi's sarcoma that are useful in formulating therapeutic alternatives.
September 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27617947/external-ear-nodule-revealing-a-disseminated-kaposi-disease
#10
Hanane Rachadi, Youssef Zemmez, Kaoutar Znati, Nadia Ismaili, Badreddine Hassam
Kaposi disease (KD) is an angiogenetic tumor process, characterized by its various clinical aspects. Its pathogenesis is multifactorial and it was attributed to HHV-8 infection. We report an original case of disseminated KD revealed by solitary lesion of external ear in a patient treated by corticosteroids for bullous pemphigoid.
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27617725/kaposi-sarcoma-of-the-eyelid-as-an-initial-manifestation-of-aids
#11
Ana Isabel Teixeira, Miguel Neno, Robert Badura, João Borges-Costa, Paulo Leal Filipe
Kaposi sarcoma (KS) is a multifocal systemic disease that originates in the vascular endothelium related to Human Herpes Virus 8 (HHV-8). In the early 1980s the first series of cases of disseminated Kaposi Sarcoma in HIV infected patients were reported. However, with the advent of highly active antiretroviral therapy (HAART) since 1997, these cases are less frequently observed by clinicians. We report the case of a 40-year-old woman, presenting with two asymptomatic purpuric nodules localized in the superior and inferior left eyelids, occluding the palpebral fissure, which were present for 4 months prior to presentation...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27551290/fulminant-anaplastic-large-cell-lymphoma-alcl-concomitant-with-primary-cytomegalovirus-cmv-infection-and-human-herpes-virus-8-hhv-8-infection-together-with-epstein-barr-virus-ebv-reactivation-in-a-patient-with-asymptomatic-hiv-infection
#12
Sven Grützmeier, Anna Porwit, Corinna Schmitt, Eric Sandström, Börje Åkerlund, Ingemar Ernberg
BACKGROUND: Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV in the development of lymphoma is not clear, though both CMV and HHV-8 have been reported in tissues adjacent to the tumour in Burkitt lymphoma patients. Here we present a patient with asymptomatic HIV infection, that contracted a primary cytomegalovirus (CMV) infection and human herpes virus 8 (HHV-8) infection...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27531516/epidemiology-of-kaposi-s-sarcoma-associated-herpesvirus-in-asia-challenges-and-opportunities
#13
Tiejun Zhang, Linding Wang
Kaposi's sarcoma -associated herpes virus (KSHV) also referred to as human herpesvirus-8 (HHV-8), is a gamma herpes virus and recently discovered human virus. Since its discovery, a myriad of studies has been conducted to explore its pathogenesis mechanisms. However, despite our consistently increasing understanding of KSHV biology and its clinical manifestations, only little progress has been made in understanding of its epidemiology characteristics which in turn hampered the management of KSHV-associated diseases and public health...
August 17, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27518127/kshv-non-structural-membrane-proteins-involved-in-the-activation-of-intracellular-signaling-pathways-and-the-pathogenesis-of-kaposi-s-sarcoma
#14
Bizunesh Abere, Thomas F Schulz
Kaposi's sarcoma (KS) is an unusual neoplasm characterized by extensive neoangiogenesis, infiltrates of inflammatory cells and atypically differentiated spindle cells of endothelial origin. KS is caused by an oncogenic γ-herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 (HHV-8). Several KSHV proteins can subvert multiple cellular angiogenic, mitogenic and inflammatory pathways. Here, we discuss the KSHV encoded membrane proteins vGPCR, K1 and K15, with a particular emphasis on their activation of cellular signaling pathways and their role in the development of specific features of KS...
August 9, 2016: Current Opinion in Virology
https://www.readbyqxmd.com/read/27517001/no-evidence-of-human-herpesvirus-8-among-iranian-patients-infected-with-hiv
#15
Amitis Ramezani, Elham Saboori, Kayhan Azadmanesh, Minoo Mohraz, Monireh Kazemimanesh, Afsaneh Karami, Mohammad Banifazl, Hanieh Golchehregan, Arezoo Aghakhani
BACKGROUND: Kaposi's sarcoma is a vascular malignancy, which frequently occurs among immunocompromised individuals such as transplant recipients and patients with acquired immunodeficiency syndrome. Human herpesvirus 8 (HHV-8) is considered the etiological agent of all forms of Kaposi's sarcoma. Though some seroepidemiological studies conducted on the prevalence of HHV-8 in Iran, there are insufficient data on the prevalence of HHV-8 viremia in HIV infected patients. We therefore, aimed to determine the prevalence of HHV-8 viremia in general population and HIV infected patients without Kaposi's sarcoma in Tehran, Iran...
July 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27505050/increased-prevalence-of-human-herpesvirus-type-8-hhv-8-genome-among-blood-donors-from-north-western-argentina
#16
María Laura Hulaniuk, Oscar Torres, Sonia Bartoli, Lisandro Fortuny, Leandro Burgos Pratx, Félix Nuñez, Horacio Salamone, Daniel Corach, Julieta Trinks, Mariela Caputo
The prevalence of HHV-8 infection varies widely in South American populations, displaying geographical variations in its distribution. The heterogeneous genetic contributions provided by the transatlantic parental populations that modified the Native American genomes may explain this epidemiological observation. Aiming to determine the prevalence of HHV-8 genome among healthy South American blood donors and its potential association with genetic ancestry, 772 individuals were screened by a highly-sensitive PCR protocol and ancestry was assessed in 414 samples...
August 9, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27463857/molecular-typing-of-human-herpesvirus-8-among-hiv-positive-in-comparison-to-hiv-negative-individuals-in-iran
#17
Sajad Varmazyar, Zabihollah Shoja, Rezvan Kakavand-Ghalehnoei, Shohreh Shahmahmoodi, Sayed Mahdi Marashi, Somayeh Jalilvand
It is still unclear whether different HHV-8 genotypes may have different pathogenic and tumorigenic properties associated with a diverse rate of disease progression. In some areas where genotype C was found to be prominent among classic KS patients, genotype A was shown to be more frequent among AIDS-associated KS patients. Genotype C was previously reported to be widespread in Iran, with genotype A being less frequent among patients with classic KS although no data are available with regards to the HHV-8 genotyping among Iranian HIV-infected patients...
July 27, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27461879/the-association-between-fructosamine-3-kinase-900c-g-polymorphism-transferrin-polymorphism-and-human-herpesvirus-8-infection-in-diabetics-living-in-south-kivu
#18
Justin C Cikomola, Karl Vandepoele, Philippe B Katchunga, Antoine S Kishabongo, Elizaveta Y Padalko, Marijn M Speeckaert, Joris R Delanghe
Prevalences of human herpesvirus-8 (HHV-8) infection and diabetes mellitus are very common in certain parts of Africa, containing iron-rich soils. We hypothesized that some genetic factors could have a link with susceptibility to HHV-8 infection. We focused on ferroportin Q248H mutation (rs11568350), transferrin (TF) polymorphism and fructosamine-3 kinase (FN3K) 900C/G polymorphism (rs1056534). The study population consisted of 210 type 2 diabetic adults and 125 healthy controls recruited in Bukavu (South Kivu)...
November 2016: Acta Tropica
https://www.readbyqxmd.com/read/27459853/rapidly-progressive-kaposi-s-sarcoma-in-an-iraqi-boy-received-valproic-acid-a-case-report-and-review-of-literature
#19
Lika'a Fasih Y Al-Kzayer, Peter Keizer, Farah T Abdulraheem, Kenji Sano, Minoru Kamata, Kazuo Sakashita, Laith A Y Habbaba, Kenichi Koike
BACKGROUND: Kaposi's sarcoma (KS), an endothelial neoplasm, is associated with human herpes virus (HHV) -8 infection. KS has four clinical sub-types: Mediterranean/classic, African/endemic, human immunodeficiency virus (HIV) -associated/epidemic, and transplantation-related/iatrogenic. Immunosuppression is an important cofactor in KS process. Classic KS (CKS) is exceedingly rare in children and when occurs, it is much more disseminated than adults. The epidemic, HIV-associated and the iatrogenic forms of childhood KS are a result of a profound and acquired T-cell deficiency...
2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27447661/kshv-mediated-angiogenesis-in-tumor-progression
#20
REVIEW
Pravinkumar Purushothaman, Timsy Uppal, Roni Sarkar, Subhash C Verma
Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is a malignant human oncovirus belonging to the gamma herpesvirus family. HHV-8 is closely linked to the pathogenesis of Kaposi's sarcoma (KS) and two other B-cell lymphoproliferative diseases: primary effusion lymphoma (PEL) and a plasmablastic variant of multicentric Castleman's disease (MCD). KS is an invasive tumor of endothelial cells most commonly found in untreated HIV-AIDS or immuno-compromised individuals. KS tumors are highly vascularized and have abnormal, excessive neo-angiogenesis, inflammation, and proliferation of infected endothelial cells...
2016: Viruses
keyword
keyword
11857
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"