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https://www.readbyqxmd.com/read/29279595/pseudomyogenic-epithelioid-sarcoma-like-hemangioendothelioma-a-rare-vascular-neoplasm-with-deceptive-morphology-and-distinctive-immunophenotype
#1
F F Cheo, K Sittampalam
Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a rare, low grade vascular (endothelial) neoplasm typically presenting as multicentric, superficial to deep nodules in extremities with a slight tendency of affecting young adult males. We report a case of pseudomyogenic hemangioendothelioma in a 15-year-old boy presenting initially with a 1 cm right thigh painless cutaneous lump. The lump was excised with the clinical impression of a sebaceous cyst. On microscopy, a poorly circumscribed, mild to moderately atypical spindle cell lesion in fascicular and storiform patterns with strikingly myoid-like eosinophilic cytoplasm was identified...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29275390/hhv-8-associated-haemophagocytic-lymphohistiocytosis-in-a-patient-with-advanced-aids
#2
Saroja Bangaru, Amanda Strickland, Dominick Cavuoti, Nainesh Shah
We present a patient with advanced AIDS admitted with recurrent shock of unclear aetiology, fevers, altered mental status and refractory cytopenias. His case posed a diagnostic challenge because evaluation of septic shock in the setting of advanced AIDS requires a time-consuming work-up for broad infectious aetiologies that can delay consideration of other diagnoses, including primary or secondary haemophagocytic lymphohistiocytosis (HLH). After this patient did not improve with supportive care and empiric antimicrobials, there was concern for HLH given that he met ≥5 of the HLH consortium criteria...
December 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29239890/omega-3-decreases-interleukin-6-levels-in-hiv-and-hhv-8-co-infected-patients-results-from-a-randomized-supplementation-trial-in-uganda
#3
Anna E Coghill, Jeanette M Schenk, Zeina Mahkoul, Jackson Orem, Warren Phipps, Corey Casper
OBJECTIVE: Kaposi sarcoma (KS) is an HIV-associated malignancy caused by human herpesvirus-8 that occurs at highest incidence in sub-Saharan Africa. KS patients often present with inflammatory symptoms associated with higher mortality. DESIGN: We conducted a double-blind, randomized, placebo-controlled study in Uganda to test whether omega-3 (ω-3) supplementation could reduce inflammation in HIV and HHV-8 co-infected adults ≥ 18 years of age. Patients with acute illness, AIDS, or advanced KS were ineligible, as were pregnant women...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29230263/-kaposi-s-sarcoma-of-the-penis-in-a-hiv-seronegative-patient
#4
Mohammed Alae Touzani, Othmane Yddoussalah
Sarcomas of the penis account for less than 5% of all tumors of the penis. They are dominated by Kaposi's sarcoma that mainly affects HIV-positive patients. However, recent studies have shown a relationship between Kaposi's sarcoma and HHV-8 infection (Human herpes virus-8), which explains why this sarcoma occurs in non-immunocompromised and HIV-seronegative patients. We here report the case of a 72-year old patient, with no previous medical history, reporting of gradual onset of tumor-like granulation tissue of 3 years duration at the level of the gland, without secondary location...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29223447/clinical-laboratory-and-imaging-findings-in-castleman-s-disease-the-subtype-decides
#5
REVIEW
Michael Haap, Julia Wiefels, Marius Horger, Annika Hoyer, Karsten Müssig
Castleman's disease (CD) is a rare lymphoproliferative disorder with its distinct unicentric (uCD) and multicentric (mCD) entities. The present work aimed at characterizing CD in more detail. From the 775 articles found by a PubMed search, 1133 cases were extracted. Two own cases were included. UCD was identified in 719 (42% males) and mCD in 416 (63% males) cases. Age in uCD was 34±17 and in mCD 48±18years. The hyaline-vascular type predominated in uCD and the plasma cell type in mCD. Clinical symptoms were more common in mCD...
November 29, 2017: Blood Reviews
https://www.readbyqxmd.com/read/29207182/antitumor-activity-of-the-synthetic-retinoid-st1926-on-primary-effusion-lymphoma-in-vitro-and-in-vivo-models
#6
Louna Karam, Bilal Houshaymi, Rana Abdel-Samad, Mariam Jaafar, Iman Halloum, Claudio Pisano, Frank Neipel, Nadine Darwiche, Raghida Abou Merhi
Primary effusion lymphoma (PEL) is a rare B-cell neoplasm, associated with Kaposi sarcoma-associated herpes virus/human herpes virus-8 (KSHV/HHV-8), arising as malignant effusions in body cavities. PEL cells do not harbor conventional genetic cancer mutations; however, their oncogenesis is mainly attributed to HHV-8 latent genes. Treatment strategies are inefficient resulting in poor prognosis of PEL patients, stressing the need for new effective therapy. ST1926 is a synthetic retinoid with favorable antitumor properties and no cross-resistance with the natural retinoid, all-trans retinoic acid...
December 5, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29204303/maxillary-sinus-kaposi-sarcoma-case-report-in-an-hiv-negative-patient-with-thymoma
#7
Bernardo Carvalho Araújo, Sara Viana Baptista, Luís Mascarenhas, Ezequiel Barros
Introduction: Kaposi sarcoma is an angioproliferative disorder that requires infection with human herpesvirus 8 (HHV-8) for its development. The majority of cases are associated with HIV infection or other immunocompromising conditions. Thymomas are occasionally associated to cytopenia, which may alter the patients' immune responses. Methods: Case report using clinical records. Results: Case report of a 46-year-old male patient diagnosed with thymoma and myasthenia gravis...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29198183/18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-imaging-in-hiv-infected-patients-with-lymphadenopathy-with-or-without-fever-and-or-splenomegaly
#8
L Jain, S Mackenzie, J B Bomanji, R Shortman, M Noursadeghi, S G Edwards, R F Miller
We audited whether 18F-Fluorodeoxyglucose positron emission tomography-computed tomography (18FDG PET-CT) imaging could discriminate between different diagnoses in HIV-infected patients presenting with lymphadenopathy, with or without fever and/or splenomegaly. Maximum standardised uptake (SUVmax) values were similar in lymphoma and mycobacterial and fungal infections and were lower but similar in those with human herpesvirus (HHV) 8-associated disease and HIV-associated reactive lymphadenopathy. Nodal 18FDG avidity, with SUVmax ≥10, excluded diagnoses of HHV 8-associated disease and miscellaneous conditions, and HIV-associated reactive lymphadenopathy was additionally excluded in those who had undetectable plasma HIV viral loads...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29198143/ebv-hhv-8-multicentric-castleman-disease-with-plasmablastic-aggregates-in-an-hiv-man-an-evolving-clinicopathologic-entity
#9
Aditya Shivane, Amy Pearce, Nadia Khatib, Mark E F Smith
We report a case of EBV+ and HHV-8+ multicentric Castleman disease with plasmablastic aggregates in an HIV-positive individual. A 41-year-old man presented in early 2015 with fevers, sweats, weight loss, intractable itching, and on subsequent testing was found to be HIV positive. Investigations showed cervical lymphadenopathy and splenomegaly. He was treated for HIV and his symptoms resolved. His symptoms recurred in January 2016, and a provisional diagnosis of multicentric Castleman disease was entertained...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29186062/viral-oncology-molecular-biology-and-pathogenesis
#10
REVIEW
Uyen Ngoc Mui, Christopher T Haley, Stephen K Tyring
Oncoviruses are implicated in approximately 12% of all human cancers. A large number of the world's population harbors at least one of these oncoviruses, but only a small proportion of these individuals go on to develop cancer. The interplay between host and viral factors is a complex process that works together to create a microenvironment conducive to oncogenesis. In this review, the molecular biology and oncogenic pathways of established human oncoviruses will be discussed. Currently, there are seven recognized human oncoviruses, which include Epstein-Barr Virus (EBV), Human Papillomavirus (HPV), Hepatitis B and C viruses (HBV and HCV), Human T-cell lymphotropic virus-1 (HTLV-1), Human Herpesvirus-8 (HHV-8), and Merkel Cell Polyomavirus (MCPyV)...
November 29, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29184003/il-10-promoter-transactivation-by-the-viral-k-rta-protein-involves-the-host-cell-transcription-factors-specificity-protein-1-and-3
#11
Masanori Miyazawa, Kohji Noguchi, Mana Kujirai, Kazuhiro Katayama, Satoshi Yamagoe, Yoshikazu Sugimoto
Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 (HHV-8) causes a persistent infection, presenting latent and lytic replication phases during its life cycle. KSHV-related diseases are associated with deregulated expression of inflammatory cytokines, including IL-6 and IL-10, but the mechanisms underlying this dysregulation are unclear. Herein, we report a molecular mechanism for KSHV-induced IL-10 gene expression. KSHV replication and transcription activator (K-RTA) is a molecular switch for the initiation of expression of viral lytic genes, and we describe, for the first time, that K-RTA significantly activates the promoter of the human IL-10 gene...
November 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29179969/-detection-of-herpes-virus-and-human-enterovirus-in-pathology-samples-using-low-density-arrays
#12
Sofía Del Carmen Martínez, Ruth Gervás Ríos, Yoana Franco Rodríguez, Cristina González Velasco, Miguel Ángel Cruz Sánchez, María Del Mar Abad Hernández
Despite the frequency of infections with herpesviridae family, only eight subtypes affect humans (Herpex Simplex Virus types 1 and 2, Varicella Zoster Virus, Epstein-Barr Virus, Citomegalovirus and Human Herpes Virus types 6, 7 and 8). Amongst enteroviruses infections, the most important are Poliovirus, Coxackievirus and Echovirus. Symptoms can vary from mild to severe and early diagnosis is of upmost importance. Nowadays, low-density arrays can detect different types of viruses in a single assay using DNA extracted from biological samples...
January 2017: Revista Española de Patología
https://www.readbyqxmd.com/read/29169276/iatrogenic-kaposi-s-sarcoma-in-an-hiv-negative-young-male-with-crohn-s-disease-and-iga-nephropathy-a-case-report-and-brief-review-of-the-literature
#13
Annika L Windon, Stuti G Shroff
BACKGROUND: Kaposi's sarcoma (KS) is a vascular tumor arising in association with human herpesvirus-8 (HHV-8) infection, and different variants show different clinical presentations. Isolated intestinal KS in the background of Crohn's disease (CD) is exceedingly rare with only 3 cases reported in the English literature (from 1966 to 2016). CASE PRESENTATION: Herein, we report a case of intestinal KS in a 21-year-old HIV-negative Ethiopian male with a long-standing history of steroid therapy for his underlying IgA nephropathy...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29165615/human-herpesvirus-8-in-perinatally-hiv-infected-children-with-interstitial-lung-disease
#14
Marcelo Comerlato Scotta, Alexandre Todorovic Fabro, Paula Renata Lima Machado, Simone Gusmão Ramos, Maria Célia Cervi, Benedito Antônio Lopes da Fonseca, Fabrizio Motta, Bento Vidal de Moura Negrini
Introduction: Human herpesvirus 8 (HHV-8) is associated with the pathogenesis of Kaposi Sarcoma and interstitial pneumonitis in adults. This study aims to evaluate association between HHV-8 and interstitial lung disease in HIV-infected children. Methods: HIV-infected children with interstitial pneumonitis underwent lung biopsies in a tertiary hospital and were investigated for HHV-8, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) using polymerase chain reaction (PCR) and immunohistochemistry in lung tissue...
November 20, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29157611/epidemiology-of-castleman-disease
#15
REVIEW
David Simpson
Castleman disease is a rare entity, including unicentric Castleman disease (UCD), human herpesvirus-8 plus Castleman disease (HHV-8+MCD), and idiopathic multicentric Castleman disease (iMCD). UCD is the most common at 16 per million person years and occurs at every age. HHV-8+MCD incidence varies widely, mostly affecting human immunodeficiency virus-positive men. iMCD is likely a more heterogeneous disease with an estimated incidence of 5 per million person years. Improved definitions should improve understanding of the epidemiology of Castleman disease and its subtypes...
February 2018: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29156319/large-scale-analysis-of-herpesviridae-in-epilepsy-patients-with-signs-of-autoimmune-encephalitis
#16
Freya Poulheim, Laura Esposito, Christian E Elger, Anna M Eis-Hübinger, Albert J Becker, Pitt Niehusmann
PURPOSE: Epilepsy is one of the most common primary brain disorders. Nonparaneoplastic autoimmune encephalitis is increasingly recognized as an important cause of adult onset epilepsy. However, only in rare cases an initiating factor of the syndrome can be identified. Autoantibody detection after central nervous herpesvirus infection indicates a postviral etiology in a subgroup of patients. In order to analyze a possible underrecognition of postinfectious autoimmunity we performed a large-scale analysis of herpesvirus DNA in cerebrospinal fluid samples from patients with clinical signs of autoimmune encephalitis...
November 17, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29150768/toe-web-intertrigo-in-kaposi-s-sarcoma-patients-a-microbiological-study-in-a-large-cohort-of-patients
#17
G Nazzaro, A Tourlaki, B Scoppio, A Restelli, A Grancini, L Brambilla
Kaposi 's sarcoma (KS) is a rare multifocal angioproliferative disease associated with human herpes virus 8 (HHV-8) infection, characterized by cutaneous nodules or plaques especially on the lower limbs. Some skin modifications, such as chronic lymphedema, plantar hyperkeratosis and interdigital desquamation, may be associated with consequent impairment of the local immunosurveillance and increased risk of some bacterial or mycotic infections. With the objective of evaluating if bacterial or mycotic infections in KS patients are supported by different microorganisms compared to control patients, we performed an observational retrospective study, comparing positive cultural swabs of interdigital intertrigo of KS patients with positive cultural swabs of interdigital intertrigo of patients admitted to our dermatologic unit during the last 10 years...
November 17, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29143319/the-full-spectrum-of-castleman-disease-273-patients-studied-over-20%C3%A2-years
#18
Eric Oksenhendler, David Boutboul, David Fajgenbaum, Adrien Mirouse, Claire Fieschi, Marion Malphettes, Laetitia Vercellino, Véronique Meignin, Laurence Gérard, Lionel Galicier
The spectrum of Castleman disease (CD) has considerably extended since its first description in 1956. Recently, an international collaborative working group has reached consensus on the diagnostic criteria and classification of CD. We herein report 273 patients with lymph node histopathology consistent with CD and investigate the newly established diagnostic criteria. Twenty of these patients with Castleman-like histopathology were removed from analyses, because they were diagnosed with an exclusionary disorder (18 with haematological malignancy)...
November 16, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29122821/metagenomic-deep-sequencing-of-aqueous-fluid-detects-intraocular-lymphomas
#19
John Gonzales, Thuy Doan, Jessica G Shantha, Michele Bloomer, Michael R Wilson, Joseph L DeRisi, Nisha Acharya
INTRODUCTION: Currently, the detection of pathogens or mutations associated with intraocular lymphomas heavily relies on prespecified, directed PCRs. With metagenomic deep sequencing (MDS), an unbiased high-throughput sequencing approach, all pathogens as well as all mutations present in the host's genome can be detected in the same small amount of ocular fluid. METHODS: In this cross-sectional case series, aqueous fluid samples from two patients were submitted to MDS to identify pathogens as well as common and rare cancer mutations...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29099112/enfermedad-de-castleman-an%C3%A3-lisis-histopatol%C3%A3-gico-e-inmunohistoqu%C3%A3-mico-de-39-casos
#20
Diana Brisa Sevilla-Lizcano, Christian Lizette Frias-Soria, Carlos Ortiz-Hidalgo
Introduction: Castleman disease (CD) is a rare lymphoproliferative that comprises two distinct clinical subtypes (unicentric and multicentric) and has two basic histopathology patterns that are hyaline-vascular (HV) and plasma-cell (PC) type. Some cases of multicentric PC disease are associated with HHV-8 infection. Objective: To present the histopathologic and immunohistochemical characteristics of 39 cases of CD. Methods: A review of cases with the diagnosis CD from the files of the Department of Pathology of the ABC Medical Centre in Mexico City was performed...
2017: Gaceta Médica de México
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