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https://www.readbyqxmd.com/read/28209751/inkt-cell-defects-in-hhv-8-associated-mcd
#1
Thomas S Uldrick
No abstract text is available yet for this article.
February 16, 2017: Blood
https://www.readbyqxmd.com/read/28205564/elevated-serum-interferon-%C3%AE-induced-protein-10-kda-is-associated-with-tafro-syndrome
#2
Noriko Iwaki, Yuka Gion, Eisei Kondo, Mitsuhiro Kawano, Taro Masunari, Hiroshi Moro, Koji Nikkuni, Kazue Takai, Masao Hagihara, Yuko Hashimoto, Kenji Yokota, Masataka Okamoto, Shinji Nakao, Tadashi Yoshino, Yasuharu Sato
Multicentric Castleman disease (MCD) is a heterogeneous lymphoproliferative disorder. It is characterized by inflammatory symptoms, and interleukin (IL)-6 contributes to the disease pathogenesis. Human herpesvirus 8 (HHV-8) often drives hypercytokinemia in MCD, although the etiology of HHV-8-negative MCD is idiopathic (iMCD). A distinct subtype of iMCD that shares a constellation of clinical features including thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O) has been reported as TAFRO-iMCD, however the differences in cytokine profiles between TAFRO-iMCD and iMCD have not been established...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28191343/molecular-epidemiology-of-kaposi-s-sarcoma-associated-herpes-virus-and-risk-factors-in-hiv-infected-patients-in-tehran-2014
#3
Khashayar Hesamizadeh, Hossein Keyvani, Farah Bokharaei-Salim, Seyed Hamidreza Monavari, Maryam Esghaei, Fatemeh Jahanbakhsh Sefidi
BACKGROUND: Kaposi's sarcoma (KS) remains the most common malignancy among HIV-infected patients. Human herpesvirus type-8 (HHV-8) is regarded as the infectious etiological agent of Kaposi's sarcoma (KSHV). Diagnostic procedures associated with KSHV are not routinely performed in HIV-infected subjects. OBJECTIVES: The main objective of this study is to obtain information on KSHV epidemiology in Iranian HIV-infected individuals. PATIENTS AND METHODS: In the present cross-sectional study, 109 patients with established HIV infection, who visited a governmental and referral center for HIV screening in Tehran (Tehran west health center (TWHC)) between May 2014 and July 2015 were enrolled according to the convenience sample strategy...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28135567/tafro-syndrome-new-subtype-of-idiopathic-multicentric-castleman-disease
#4
REVIEW
Gordan Srkalovic, Inga Marijanovic, Maya B Srkalovic, David C Fajgenbaum
Castleman disease (CD) describes a group of three rare and poorly understood lymphoproliferative disorders that have heterogeneous clinical symptoms and common lymph node histopathological features. Unicentric CD (UCD) involves a single region of enlarged nodes. Multicentric CD (MCD) involves multiple regions of enlarged lymph nodes, constitutional symptoms, and organ dysfunction due to a cytokine storm often including interleukin 6. MCD is further divided into Human Herpes Virus-8 (HHV-8)-associated MCD, which occurs in immunocompromised individuals, and HHV-8-negative/idiopathic MCD (iMCD)...
January 26, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28131739/cross-sectional-and-longitudinal-investigation-of-human-herpesvirus-8-seroprevalence-in-hiv-1-infected-individuals-in-osaka-japan
#5
Dai Watanabe, Yudai Yamamoto, Sachiko Suzuki, Misa Ashida, Erina Matsumoto, Satomi Yukawa, Kazuyuki Hirota, Motoko Ikuma, Takashi Ueji, Daisuke Kasai, Yasuharu Nishida, Tomoko Uehira, Takuma Shirasaka
INTRODUCTION: High human herpesvirus 8 (HHV-8) seroprevalence has been reported in men who have sex with men (MSM) and are infected with HIV-1. However, it is unclear when they become infected with HHV-8. Thus, we conducted cross-sectional and longitudinal investigations of HHV-8 seroprevalence in HIV-1-infected individuals in Osaka, Japan. PATIENTS AND METHODS: Plasma was collected from 121 individuals infected with HIV-1 and the anti-HHV-8 antibody titer was measured using an enzyme-linked immunosorbent assay with whole virus lysate...
January 25, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28121161/regulatory-t-cell-effect-on-cd8-t-cell-responses-to-human-herpesvirus-8-infection-and-development-of-kaposi-s-sarcoma
#6
Lauren M Lepone, Giovanna Rappocciolo, Paolo A Piazza, Diana M Campbell, Frank Jenkins, Charles Rinaldo
We assessed CD8+ T cell reactivity to human herpesvirus 8 (HHV-8; Kaposi's sarcoma-associated herpesvirus) and the role of CD4+CD25hiFoxP3+ regulatory T cells (Treg) in HHV-8 and HIV co-infected participants of the Multicenter AIDS Cohort Study who did or did not develop Kaposi's sarcoma (KS). There were similarly low CD8+ T cell interferon γ responses to MHC class I-restricted epitopes of HHV-8 lytic and latent proteins over 5.7 years prior to KS in participants who developed KS compared to those that did not...
January 25, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28120699/use-of-plasma-human-herpesvirus-8-viral-load-measurement-evaluation-of-practice-in-three-uk-hiv-treatment-centres
#7
D B Nugent, D Webster, D Mabayoje, E Chung, K El Bouzidi, A O'Sullivan, J Ainsworth, R F Miller
A retrospective audit of plasma human herpesvirus-8 (HHV-8) viral load testing was performed in three HIV treatment centres over 24 months. Reasons for testing (360 tests) were: symptoms of systemic inflammatory response syndrome (SIRS) (fever, lymphadenopathy and raised inflammatory markers); monitoring in known HHV-8 pathology other than Kaposi sarcoma (KS); investigation of known/suspected KS, and other/no reason. Of patients with multicentric Castleman disease (MCD), 14/16 (88%) had detectable plasma HHV-8, as did 27/45 (60%) with biopsy proven or clinically confirmed KS, and 6/19 (32%) with lymphoma...
February 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28117495/elevated-serum-psa-is-associated-with-human-herpesvirus-8-infection-and-increased-circulating-cytokine-levels-in-men-from-tobago
#8
Jill D Henning, Jaideep M Karamchandani, Luis A Bonachea, Clareann H Bunker, Alan L Patrick, Frank J Jenkins
BACKGROUND: Serum-prostate specific antigen (PSA) levels have been used for many years as a biomarker for prostate cancer. This usage is under scrutiny due to the fact that elevated PSA levels can be caused by other conditions such as benign prostatic hyperplasia and infections of or injury to the prostate. As a result, the identification of specific pathogens capable of increasing serum levels of PSA is important. A potential candidate responsible for elevated PSA is human herpesvirus 8 (HHV-8)...
January 24, 2017: Prostate
https://www.readbyqxmd.com/read/28100459/clinical-and-pathological-characteristics-of-hiv-and-hhv8-negative-castleman-disease
#9
Li Yu, Meifeng Tu, Jorge Cortes, Zijun Y Xu-Monette, Roberto N Miranda, Jun Zhang, Robert Z Orlowski, Sattva Neelapu, Prajwal C Boddu, Mary A Akosile, Thomas S Uldrick, Robert Yarchoan, L Jeffrey Medeiros, Yong Li, David C Fajgenbaum, Ken H Young
Castleman disease (CD) comprises three poorly-understood lymphoproliferative variants that share several common histopathological features. Unicentric CD (UCD) is localized to a single region of lymph nodes. Multicentric CD (MCD) manifests with systemic inflammatory symptoms and organ dysfunction due to cytokine dysregulation, and involves multiple lymph node regions. Human herpes virus-8 causes MCD (HHV-8-associated MCD) in immunocompromised individuals, such as HIV infected patients. However, greater than 50% MCD cases are HIV and HHV-8 negative, defined as idiopathic (iMCD)...
January 18, 2017: Blood
https://www.readbyqxmd.com/read/28099593/angiosarcoma-in-hiv-negative-patients-is-not-associated-with-hhv-8
#10
João Avancini, José Antonio Sanches, Andre Pires Zanata Cherubim, Renato Pazzini, Cristina Mendes de Oliveira, Laura Masami Sumita, Neusa Yuriko Sakai Valente, Claudio Sergio Pannuti, Cyro Festa
BACKGROUND: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined. OBJECTIVE: To investigate the relationship between the presence of HHV-8 and angiosarcoma. METHODS: In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28087540/international-evidence-based-consensus-diagnostic-criteria-for-hhv-8-negative-idiopathic-multicentric-castleman-disease
#11
David C Fajgenbaum, Thomas S Uldrick, Adam Bagg, Dale Frank, David Wu, Gordan Srkalovic, David Simpson, Amy Y Liu, David Menke, Shanmuganathan Chandrakasan, Mary Jo Lechowicz, Raymond S M Wong, Sheila Pierson, Michele Paessler, Jean-François Rossi, Makoto Ide, Jason Ruth, Michael Croglio, Alexander Suarez, Vera Krymskaya, Amy Chadburn, Gisele Colleoni, Sunita Nasta, Raj Jayanthan, Christopher S Nabel, Corey Casper, Angela Dispenzieri, Alexander Fosså, Dermot Kelleher, Razelle Kurzrock, Peter Voorhees, Ahmet Dogan, Kazuyuki Yoshizaki, Frits van Rhee, Eric Oksenhendler, Elaine S Jaffe, Kojo S J Elenitoba-Johnson, Megan S Lim
Human Herpesvirus-8(HHV-8)-negative, idiopathic multicentric Castleman disease (iMCD) is a rare and life-threatening disorder involving systemic inflammatory symptoms, polyclonal lymphoproliferation, cytopenias, and multiple organ system dysfunction due to a cytokine storm often including interleukin-6. iMCD accounts for one-third to one-half of all cases of MCD and can occur in individuals of any age. Accurate diagnosis is challenging, as no standard diagnostic criteria or diagnostic biomarkers currently exist, and there is significant overlap with malignant, autoimmune, and infectious disorders...
January 13, 2017: Blood
https://www.readbyqxmd.com/read/28060720/inkt-and-memory-b-cells-alterations-in-hhv-8-multicentric-castleman-disease
#12
Zineb Sbihi, Antoine Dossier, David Boutboul, Lionel Galicier, Christophe Parizot, Amandine Emarre, Bénédicte Hoareau, Nicolas Dupin, Anne-Geneviève Marcelin, Anne Oudin, Claire Fieschi, Félix Agbalika, Brigitte Autran, Eric Oksenhendler, Guislaine Carcelain
Human herpesvirus 8 (HHV-8) is the causative agent of Kaposi's sarcoma (KS) and multicentric Castleman disease (MCD), a life-threatening, virally-induced, B-cell lymphoproliferative disorder. HHV-8 is a B-lymphotropic gamma-herpesvirus closely related to the Epstein-Barr virus (EBV). Invariant natural killer T (iNKT) cells are innate-like T cells that play a role in antiviral immunity, specifically in controlling viral replication in EBV-infected B cells. Decline of iNKT cells is associated with age or HIV-infection, both situations associated with HHV-8-related diseases...
November 9, 2016: Blood
https://www.readbyqxmd.com/read/28013535/human-herpes-virus-8-epstein-barr-virus-copositive-plasmablastic-microlymphoma-arising-in-multicentric-castleman-s-disease-of-an-immunocompetent-patient
#13
Yong-Moon Lee, Jin-Man Kim, Sam-Yong Kim
No abstract text is available yet for this article.
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27914460/possible-mechanisms-of-acquisition-of-herpesvirus-virokines
#14
E A Gorshkova, E S Shilov
The genomes of certain types of human and primate herpesviruses contain functional homologs of important host cytokines (IL-6, IL-17, and IL-10), or so-called virokines. Virokines can interact with immune cell receptors, transmit a signal to them, and thus switch the type of immune response that facilitates viral infection development. In this work, we have summarized possible ways of virokine origin and proposed an evolutionary scenario of virokine acquisition with involvement of retroviral coinfection of the host...
November 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27902590/genotypic-distribution-of-hhv-8-in-aids-individuals-without-and-with-kaposi-sarcoma-is-genotype-b-associated-with-better-prognosis-of-aids-ks
#15
Tania Regina Tozetto-Mendoza, Karim Yaqub Ibrahim, Adriana Fumie Tateno, Cristiane Mendes de Oliveira, Laura Massami Sumita, Maria Carmem Arroyo Sanchez, Expedito José Luna, Ligia Camara Pierrotti, Jan Felix Drexler, Paulo Henrique Braz-Silva, Claudio Sérgio Pannuti, Camila Malta Romano
AIDS-associated Kaposi's sarcoma (AIDS-KS) caused by human herpes virus 8 (HHV-8) is the most severe and resistant form of KS tumor. Our aim was to verify whether there is an association between HHV-8 variability and development of AIDS-KS in Brazil by comparing the HHV-8 variability between individuals without and with KS. Saliva samples and blood, when available, were analyzed by polymerase chain reaction (PCR) techniques for detection of the fragments of ORF K1 of HHV-8, which were then genotyped and analyzed regarding the genetic variability...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27894280/is-there-any-association-between-sarcoidosis-and-infectious-agents-a-systematic-review-and-meta-analysis
#16
Tiago Esteves, Gloria Aparicio, Vicente Garcia-Patos
BACKGROUND: During the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. With the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. METHODS: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement from the Cochrane collaboration guidelines...
November 28, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27872774/pulmonary-kaposi-sarcoma-an-uncommon-cause-of-respiratory-failure-in-the-era-of-highly-active-antiretroviral-therapy-case-report-and-review-of-the-literature
#17
Stanley M Nwabudike, Stefan Hemmings, Yonette Paul, Yordanis Habtegebriel, Octavius Polk, Alem Mehari
Kaposi Sarcoma (KS) is the most common malignancy associated with Acquired Immune Deficiency Syndrome (AIDS) and is caused by Human Herpesvirus 8 (HHV 8) or Kaposi Sarcoma Herpesvirus (KSHV). In about 90% of cases Kaposi Sarcoma is associated with cutaneous lesions; however visceral disease can occur in the absence of cutaneous involvement. In the era of Highly Active Antiretroviral Therapy (HAART), the incidence of KS has declined. Clinical features of pulmonary KS might be difficult to distinguish from pneumonia in the immunocompromised patients and could lead to diagnostic challenges...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27812258/presentation-and-outcome-of-castleman-s-disease-in-immunocompetent-hosts
#18
Gaurav Prakash, Amanjeet Bal, Pankaj Malhotra, Vaishali Aggarwal, Alka Khadwal, Vikas Suri, Sanjay Jain, Savita Kumari, Radhika Srinivasan, Ashim Das, Neelam Varma, Subhash Varma
Castleman's disease (CD) is a heterogeneous lymphoproliferative disorder of unknown aetiology. Mostly, this disorder is seen in immunocompromised hosts. It is known to be associated with systemic disorders like HIV, HHV-8, lymphoma, and Kaposi sarcoma. As of today, the clinical behaviour and outcome of CD in immunocompetent host remains suboptimally studied. We analyzed consecutively treated cases of CD presented to our centre in last 12 years. Case record files were studied for patient's characteristics, clinical presentation, baseline laboratory and pathologic parameters, therapy and outcome...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27790727/durable-remission-of-both-multicentric-castleman-s-disease-and-kaposi-s-sarcoma-with-valganciclovir-rituximab-and-liposomal-doxorubicin-in-an-hhv-8-positive-hiv-negative-patient
#19
C Murphy, E Hawkes, F Chionh, G Chong
WHAT IS KNOWN AND OBJECTIVE: Human herpesvirus-8 (HHV-8)-positive, HIV-negative multicentric Castleman's disease is a rare lymphoproliferative disorder with no standardized treatment. Concurrent Kaposi's sarcoma, another HHV-8-related disease, is uncommon in HIV-negative patients. The role of antiviral therapy and rituximab in HIV-negative patients is not well established. CASE DESCRIPTION: We report a case of a 5-year, durable remission of HHV-8-positive, HIV-negative comorbid multicentric Castleman's disease and Kaposi's sarcoma treated with long-term valganciclovir, following initial rituximab and liposomal doxorubicin...
February 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27777802/tafro-syndrome-associated-with-ebv-and-successful-triple-therapy-treatment-case-report-and-review-of-the-literature
#20
Malorie Simons, Emmanuel Apor, James N Butera, Diana O Treaba
TAFRO syndrome is a rare constellation of symptoms: thrombocytopenia, anasarca, reticulin fibrosis of the bone marrow, renal dysfunction, and organomegaly. Its pathogenesis involves an excessive and inappropriate cytokine storm, most notably from IL-6, causing multiorgan failure; however, its etiology is undetermined. Starting in 2012, TAFRO syndrome was first identified in Japan as an atypical variant of Castleman's disease. Previous reports include various different treatment protocols with inconsistent survival outcomes...
2016: Case Reports in Hematology
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