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https://www.readbyqxmd.com/read/28732406/quantifying-deforestation-and-forest-degradation-with-thermal-response
#1
Hua Lin, Yajun Chen, Qinghai Song, Peili Fu, James Cleverly, Vincenzo Magliulo, Beverly E Law, Christopher M Gough, Lukas Hörtnagl, Filippo Di Gennaro, Giorgio Matteucci, Leonardo Montagnani, Pierpaolo Duce, Changliang Shao, Tomomichi Kato, Damien Bonal, Eugénie Paul-Limoges, Jason Beringer, John Grace, Zexin Fan
Deforestation and forest degradation cause the deterioration of resources and ecosystem services. However, there are still no operational indicators to measure forest status, especially for forest degradation. In the present study, we analysed the thermal response number (TRN, calculated by daily total net radiation divided by daily temperature range) of 163 sites including mature forest, disturbed forest, planted forest, shrubland, grassland, savanna vegetation and cropland. TRN generally increased with latitude, however the regression of TRN against latitude differed among vegetation types...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28732382/novel-strategies-to-prevent-the-development-of-multidrug-resistance-mdr-in-cancer
#2
REVIEW
Jinglu Wang, Nicole Seebacher, Huirong Shi, Quancheng Kan, Zhenfeng Duan
The development of multidrug resistance (MDR) is one of the major challenges to the success of traditional chemotherapy treatment in cancer patients. Most studies to date have focused on strategies to reverse MDR following its development. However, agents utilizing this approach have proven to be of limited clinical use, failing to demonstrate an improvement in therapeutic efficacy with almost no significant survival benefits observed in cancer clinical trials. An alternative approach that has been applied is to prevent or delay MDR prior or early in its development...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732374/the-protective-effect-of-pft%C3%AE-on-alcohol-induced-osteonecrosis-of-the-femoral-head
#3
Yi-Xuan Chen, Dao-Yu Zhu, Jun-Hui Yin, Wen-Jing Yin, Yue-Lei Zhang, Hao Ding, Xiao-Wei Yu, Jiong Mei, You-Shui Gao, Chang-Qing Zhang
Epidemiologic studies have shown alcohol plays a pivotal role in the development of osteonecrosis of the femoral head (ONFH). The aim of this study was to explore the underlying mechanism of alcohol-induced ONFH and the protective effect of pifithrin-α (PFTα). In vitro, we found ethanol treatment significantly activated p53, suppressed Wnt/β-catenin signaling and inhibited osteogenic-related proteins. Furthermore, by separating the cytoplasmic and nuclear proteins, we found ethanol inhibited osteogenesis by impairing the accumulation of β-catenin in both the cytoplasm and nucleus in human bone mesenchymal stem cells (hBMSCs), which resulted from activating glycogen synthase kinase-3β (GSK-3β)...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732350/the-prevalence-of-polycystic-ovary-syndrome-in-reproductiveaged-women-of-different-ethnicity-a-systematic-review-and-meta-analysis
#4
Tao Ding, Paul J Hardiman, Irene Petersen, Fang-Fang Wang, Fan Qu, Gianluca Baio
The prevalence of PCOS was investigated in many studies in different continents. However, there is no established prevalence of PCOS for distinct ethnic groups. In the current analysis, we conducted searches in PubMed, The Cochrane Library, EMBASE, CINAHL up to Jan. 2017 to identify studies reporting prevalence of PCOS in the general female population. Forty-two studies were identified, with 13 eligible for evidence synthesis. The prevalence among different ethnicity was estimated using random effect modelling...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732348/alcohol-consumption-and-gastric-cancer-risk-a-meta-analysis-of-prospective-cohort-studies
#5
Xue Han, Li Xiao, Yao Yu, Yu Chen, Hai-Hua Shu
We performed this meta-analysis to explore the precise quantification relationship between alcohol consumption and gastric cancer and to provide evidence for preventing gastric cancer. We searched PubMed, Embase, and Web of Science for articles published up to December 2016, and identified 23 cohort studies that included a total population of 5,886,792 subjects. We derived meta-analytic estimates using random-effects models, taking into account correlations between estimates. We also investigated the dose-response relationship between gastric cancer risk and alcohol consumption...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732326/therapeutic-applications-of-histone-deacetylase-inhibitors-in-sarcoma
#6
REVIEW
Fan Tang, Edwin Choy, Chongqi Tu, Francis Hornicek, Zhenfeng Duan
Sarcomas are a rare group of malignant tumors originating from mesenchymal stem cells. Surgery, radiation and chemotherapy are currently the only standard treatments for sarcoma. However, their response rates to chemotherapy are quite low. Toxic side effects and multi-drug chemoresistance make treatment even more challenging. Therefore, better drugs to treat sarcomas are needed. Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are epigenetic modifying agents that can inhibit sarcoma growth in vitro and in vivo through a variety of pathways, including inducing tumor cell apoptosis, causing cell cycle arrest, impairing tumor invasion and preventing metastasis...
July 6, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28732316/a-user-friendly-technical-set-up-for-infrared-photography-of-forensic-findings
#7
Thomas Rost, Nicole Kalberer, Eva Scheurer
Infrared photography is interesting for a use in forensic science and forensic medicine since it reveals findings that normally are almost invisible to the human eye. Originally, infrared photography has been made possible by the placement of an infrared light transmission filter screwed in front of the camera objective lens. However, this set-up is associated with many drawbacks such as the loss of the autofocus function, the need of an external infrared source, and long exposure times which make the use of a tripod necessary...
July 10, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28732312/drug-eluting-scaffold-inhibited-in-vivo-pancreatic-tumorigenesis-by-engaging-murine-ccr4-cd8-t-cells
#8
Qian Zhan, Baiyong Shen, Yuan Fang, Xiaxing Deng, Hao Chen, Jiabin Jin, Chenghong Peng, Hongwei Li
CCL17 is well known for its ability to engage CCR4(+)CD8(+) T cells, which have been shown to play a critical role in preventing tumorigenesis. In this study, we attempted to inhibit in vivo pancreatic tumorigenesis by engaging murine CCR4(+)CD8(+) T cells through a drug-eluting scaffold with a payload of CCL17. The drug-eluting scaffold was fabricated by electrospinning polyglyconate and porcine gelatin. The electrospun scaffold featured randomly distributed non-woven fibers with diameters ranging from 1μm to 4μm...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28732277/assessment-of-metal-and-pah-profiles-in-suds-soil-based-on-an-improved-experimental-procedure
#9
Damien Tedoldi, Ghassan Chebbo, Daniel Pierlot, Yves Kovacs, Marie-Christine Gromaire
The increasing use of infiltration-based systems for stormwater management questions the soil's ability to act as a long-term filter for runoff contaminants, and brings about operational matters regarding the most effective maintenance practices to enhance contaminant retention in SUDS. This paper reports the vertical extent of metal and PAH contamination in the soil of seven source-control devices in operation for more than 10 years, assessed via a two-step sampling strategy to optimize the representativeness of the contamination profiles...
July 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28732219/perioperative-systemic-corticosteroids-in-orthognathic-surgery-a-systematic-review-and-meta-analysis
#10
REVIEW
Simon Jean, Pierre-Luc Dionne, Carl Bouchard, Luc Giasson, Alexis F Turgeon
PURPOSE: Perioperative systemic corticosteroids are broadly used in orthognathic surgery to prevent postoperative complications, but it is unclear whether this practice is beneficial and concerns about potential side effects have been raised. The purpose of this systematic review and meta-analysis was to assess the effects of perioperative systemic corticosteroids on clinically important outcomes in patients undergoing orthognathic surgery. MATERIALS AND METHODS: The authors conducted a systematic review of randomized controlled trials evaluating the effect of systemic corticosteroids in orthognathic surgery compared with placebo or any other intervention...
June 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28732179/kgf-enhances-oral-epithelial-adhesion-and-rete-peg-elongation-via-integrins
#11
G L Sa, X P Xiong, J G Ren, J Y Wang, H F Xia, Z K Liu, S G He, Y F Zhao
Oral epithelial adhesion to the lamina propria underlies the physiologic function of the oral mucosa and contributes to resisting bacterial invasion, preventing body fluid loss, and maintaining routine chewing; thus, understanding the factors that positively influence oral epithelial adhesion is a research topic of great interest. Rete pegs contribute to oral epithelial adhesion by enlarging the contact areas, whereas integrins are the major molecules that mediate epithelial cell adhesion to the basement membrane...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28732172/role-of-endothelin-1-and-its-receptors-eta-and-etb-in-the-survival-of-human-vascular-endothelial-cells
#12
Marianne Mikhail, Pierre H Vachon, Pedro D'Orleans-Juste, Danielle Jacques, Ghassan Bkaily
Our previous work showed the presence of endothelin-1 (ET-1) receptors, ETA and ETB, in human vascular endothelial cells (hVECs). In this study, we wanted to verify whether ET-1 via the activation of its receptors ETA and/or ETB (ETAR and ETBR respectively) play a role in the survival of hVECs. Our results showed that treatment of hVECs with ET-1 prevented apoptosis induced by genistein, an effect that was mimicked by treatment with ETBR specific agonist IRL1620. Furthermore, blockade of ETBR with the selective ETBR antagonist A192621 prevented the anti-apoptotic effect of ET-1 in hVECs...
July 21, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28732170/angiotensin-ii-receptors-modulation-of-calcium-homeostasis-in-human-vascular-endothelial-cells
#13
Maud Kamal, Danielle Jacques, Ghassan Bkaily
Angiotensin II (AngII) plays an important role in the regulation of vascular smooth muscle function. However, little is known about AngII and its receptors AT1 (AT1R) and AT2 (AT2R) and their modulation of intracellular calcium in vascular endothelial cells (VECs) in general and more particularly of human origin. Using western blots, our results showed that AT1Rs and AT2Rs are present in human VECs (hVECs). Using quantitative 3D confocal imaging, our results showed that AngII is present at the cytoplasmic and nucleoplasmic levels and its relative density is lower in the nucleoplasm...
July 21, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28732120/the-prevalence-of-molar-incisor-hypomineralization-evidence-from-70-studies
#14
Dongdong Zhao, Bao Dong, Dandan Yu, Qiongqiong Ren, Yehuan Sun
OBJECTIVE: A growing number of studies have investigated the prevalence of Molar Incisor Hypomineralization (MIH) around the world. The aim of this study was to systematically estimate the pooled prevalence of MIH. METHODS: A comprehensive literature research was completed in English and Chinese databases. Random effect models were used to calculate the pooled prevalence. To address the heterogeneity, meta-regression, and sensitivity analyzes were conducted. Publication bias was estimated by trim and fill method...
July 21, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28732116/strategies-for-preventing-antibody-light-chain-truncation
#15
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28732099/expression-of-concern-schietroma-m-cecilia-em-carlei-f-sista-f-de-santis-g-lancione-l-amicucci-g-dexamethasone-for-the-prevention-of-recurrent-laryngeal-nerve-palsy-and-other-complications-after-thyroid-surgery-a-randomized-double-blind-placebo-controlled-trial
#16
https://www.readbyqxmd.com/read/28732086/risk-of-stomach-cancer-in-aotearoa-new-zealand-a-m%C3%A4-ori-population-based-case-control-study
#17
Lis Ellison-Loschmann, Andrew Sporle, Marine Corbin, Soo Cheng, Pauline Harawira, Michelle Gray, Tracey Whaanga, Parry Guilford, Jonathan Koea, Neil Pearce
Māori, the indigenous people of New Zealand, experience disproportionate rates of stomach cancer, compared to non-Māori. The overall aim of the study was to better understand the reasons for the considerable excess of stomach cancer in Māori and to identify priorities for prevention. Māori stomach cancer cases from the New Zealand Cancer Registry between 1 February 2009 and 31 October 2013 and Māori controls, randomly selected from the New Zealand electoral roll were matched by 5-year age bands to cases...
2017: PloS One
https://www.readbyqxmd.com/read/28732085/point-of-care-screening-for-hepatitis-b-virus-infection-in-pregnant-women-at-an-antenatal-clinic-a-south-african-experience
#18
Nafiisah Chotun, Wolfgang Preiser, Christoffel Johannes van Rensburg, Pedro Fernandez, Gerhard Barnard Theron, Dieter Glebe, Monique Ingrid Andersson
BACKGROUND & AIMS: Elimination of HIV and syphilis mother-to-child transmission (MTCT) has received much attention but little consideration has been given to the possibility of elimination of HBV MTCT. In sub-Saharan Africa, HBV vertical transmission continues to be reported and it remains an important public health problem. This study aimed to assess the feasibility of screening pregnant women for HBV using a point-of-care (POC) test and implementing interventions to prevent HBV MTCT...
2017: PloS One
https://www.readbyqxmd.com/read/28732068/effects-of-liver-stage-clearance-by-primaquine-on-gametocyte-carriage-of-plasmodium-vivax-and-p-falciparum
#19
Rahel Wampfler, Natalie E Hofmann, Stephan Karl, Inoni Betuela, Benson Kinboro, Lina Lorry, Mariabeth Silkey, Leanne J Robinson, Ivo Mueller, Ingrid Felger
BACKGROUND: Primaquine (PQ) is the only currently licensed antimalarial that prevents Plasmodium vivax (Pv) relapses. It also clears mature P. falciparum (Pf) gametocytes, thereby reducing post-treatment transmission. Randomized PQ treatment in a treatment-to-reinfection cohort in Papua New Guinean children permitted the study of Pv and Pf gametocyte carriage after radical cure and to investigate the contribution of Pv relapses. METHODS: Children received radical cure with Chloroquine, Artemether-Lumefantrine plus either PQ or placebo...
July 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28732058/the-role-of-a-fads1-polymorphism-in-the-association-of-fatty-acid-blood-levels-bmi-and-blood-pressure-in-young-children-analyses-based-on-path-models
#20
Maike Wolters, Carmen Dering, Alfonso Siani, Paola Russo, Jaakko Kaprio, Patrizia Risé, Luis A Moreno, Stefaan De Henauw, Kirsten Mehlig, Toomas Veidebaum, Denés Molnár, Michael Tornaritis, Licia Iacoviello, Yannis Pitsiladis, Claudio Galli, Ronja Foraita, Claudia Börnhorst
BACKGROUND: The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP...
2017: PloS One
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