keyword
https://read.qxmd.com/read/38497845/mechanochromic-hydrogel-fibers-with-multiple-fluorescent-colors
#21
JOURNAL ARTICLE
Bo Xu, Jin Yang, Yinghe Yang, Jiping Yang, Zhijian Wang
Mechanochromic polymers can change their color in reimsponse to external force and have shown promising applications in stress sensing and failure warning. They are usually obtained as thin film or bulky specimen. The mechanochromic fibers, which could be used to make smart fabrics, have been seldom reported due to the lack of efficient fabrication techniques. In this work, we report a general method using photo-polymerization of microgel solution in a template tube to produce mechanochromic hydrogel fibers...
March 18, 2024: Macromolecular Rapid Communications
https://read.qxmd.com/read/38497839/clinical-and-laboratory-diagnosis-of-mayaro-virus-mayv-current-status-and-opportunities-for-further-development
#22
REVIEW
Severino Jefferson Ribeiro da Silva, Larissa Krokovsky
The recent outbreaks related to Mayaro virus (MAYV) infection in the Americas have brought this neglected virus as a potential threat to global public health. Given the range of symptoms that can be associated with MAYV infection, it can be challenging to diagnose individuals based on clinical signs, especially in countries with simultaneous circulation of other mosquito-borne viruses, such as dengue virus (DENV) and chikungunya virus (CHIKV). With this challenge in mind, laboratory-based diagnosis assumes a critical role in the introduction of measures to help prevent virus dissemination and to adequately treat patients...
March 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38497827/sex-differences-and-driving-impairment-related-to-psychoactive-substances
#23
JOURNAL ARTICLE
Claudio Terranova, Clara Cestonaro, Alessandro Cinquetti, Federica Trevissoi, Donata Favretto, Guido Viel, Anna Aprile
OBJECTIVE: The first aim of the study was to identify sex differences in the use of psychoactive substances among subjects with a previous driving under the influence (DUI) episode. The secondary objective was to propose specific strategies for medico-legal improvements. METHODS: This was a retrospective observational study that took place between June 1, 2019, and August 31, 2023. It was conducted on DUI subjects examined for reinstatement of their driver's license using an integrated medico-legal and toxicological approach...
March 18, 2024: Traffic Injury Prevention
https://read.qxmd.com/read/38497819/competitive-fungal-commensalism-mitigates-candidiasis-pathology
#24
JOURNAL ARTICLE
Jarmila Sekeresova Kralova, Catalina Donic, Bareket Dassa, Ilana Livyatan, Paul Mathias Jansen, Shifra Ben-Dor, Lena Fidel, Sébastien Trzebanski, Lian Narunsky-Haziza, Omer Asraf, Ori Brenner, Hagit Dafni, Ghil Jona, Sigalit Boura-Halfon, Noa Stettner, Eran Segal, Sascha Brunke, Yitzhak Pilpel, Ravid Straussman, David Zeevi, Petra Bacher, Bernhard Hube, Neta Shlezinger, Steffen Jung
The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions of commensal fungi to host fitness remain incompletely understood. Here, we report the identification of a new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization and significantly reduced the commensal C. albicans burden in colonized animals. Following immunosuppression of C. albicans colonized mice, competitive fungal commensalism thereby mitigated fatal candidiasis...
May 6, 2024: Journal of Experimental Medicine
https://read.qxmd.com/read/38497810/effects-of-kratom-on-driving-results-from-a-cross-sectional-survey-ecological-momentary-assessment-and-pilot-simulated-driving-study
#25
JOURNAL ARTICLE
C Austin Zamarripa, Tory R Spindle, Leigh V Panlilio, Justin C Strickland, Jeffrey D Feldman, Matthew D Novak, David H Epstein, Kelly E Dunn, Christopher R McCurdy, Abhisheak Sharma, Michelle A Kuntz, Sushobhan Mukhopadhyay, Kanumuri Siva Rama Raju, Jeffrey M Rogers, Kirsten E Smith
OBJECTIVES: Despite widespread kratom use, there is a lack of knowledge regarding its effects on driving. We evaluated the self-reported driving behaviors of kratom consumers and assessed their simulated-driving performance after self-administering kratom products. METHODS: We present results from: 1) a remote, national study of US adults who regularly use kratom, and 2) an in-person substudy from which we re-recruited participants. In the national study ( N  = 357), participants completed a detailed survey and a 15-day ecological momentary assessment (EMA) that monitored naturalistic kratom use...
March 18, 2024: Traffic Injury Prevention
https://read.qxmd.com/read/38497801/fine-particulate-matter-noise-pollution-and-greenspace-and-prostate-cancer-risk-in-the-prostate-lung-colorectal-and-ovarian-plco-cancer-screening-trial-cohort
#26
JOURNAL ARTICLE
Aleah L Thomas, Jongeun Rhee, Jared A Fisher, Marie-Josèphe Horner, Rena R Jones
BACKGROUND: Greenspace is hypothesized as being protective against cancer, whereas noise pollution and fine particulate matter (<2.5 µm in diameter, PM2.5) are both potential risk factors. Findings from recent studies of greenspace and PM2.5 with prostate cancer are not conclusive and the association between noise exposure and cancer has not been evaluated in a U.S. METHODS: We assessed PM2.5, noise, and greenspace exposure using spatiotemporal models and satellite-based estimates at enrollment addresses for N=43,184 male participants of the prospective Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial cohort (enrolled 1994-2001)...
March 18, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38497795/reproductive-factors-related-to-childbearing-and-a-novel-automated-mammographic-measure-v
#27
JOURNAL ARTICLE
Lusine Yaghjyan, Zifan Wang, Erica T Warner, Bernard Rosner, John Heine, Rulla M Tamimi
BACKGROUND: We investigated the associations between several reproductive factors related to childbearing and the variation (V) measure (a novel, objective, single summary measure of breast image intensity) by menopausal status. METHODS: Our study included 3,814 cancer-free women within the Nurses' Health Study (NHS) and NHSII cohorts. The data on reproductive variables and covariates were obtained from biennial questionnaires closest to the mammogram date. V-measures were obtained from mammographic images using a previously developed algorithm capturing the standard deviation of pixel values...
March 18, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38497792/correction-to-impact-of-elevated-lipoprotein-a-on-coronary-artery-disease-phenotype-and-severity
#28
(no author information available yet)
No abstract text is available yet for this article.
March 18, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38497746/social-determinants-of-violence-against-adolescent-married-women-and-how-the-women-respond-to-it-a-qualitative-study-in-the-kurdish-areas-of-iran
#29
JOURNAL ARTICLE
Javad Yoosefi Lebni, Mandana Saki, Darya Madineh, Arash Ziapour, Ahmad Ahmadi, Ali Torabi
OBJECTIVE: It is crucial to identify the factors that influence violence against women, one of Iran's most significant health and social issues. Thus, the purpose of this research is to explore the social determinants of violence against adolescent married women and how the women respond to it in the Kurdish areas of Iran via a qualitative approach. METHOD: The present study was conducted with a qualitative approach and the conventional content analysis method among 33 married adolescent women who experienced violence and key informants in the Kurdish areas of Iran...
March 18, 2024: Psychological Trauma: Theory, Research, Practice and Policy
https://read.qxmd.com/read/38497742/a-poly-aptamer-encoded-dna-nanocatcher-informs-efficient-virus-trapping
#30
JOURNAL ARTICLE
Yunhua Guo, Wenzhe Song, Yuhang Dong, Xuejun Wang, Guangjun Nie, Feng Li
Broad-spectrum antiviral platforms are always desired but still lack the ability to cope with the threats to global public health. Herein, we develop a poly aptamer encoded DNA nanocatcher platform that can trap entire virus particles to inhibit infection with a broad antiviral spectrum. Ultralong single-stranded DNA (ssDNA) containing repeated aptamers was synthesized as the scaffold of a nanocatcher via a biocatalytic process, wherein mineralization of magnesium pyrophosphate on the ssDNA could occur and consequently lead to the formation of nanocatcher with interfacial nanocaves decorated with virus-binding aptamers...
March 18, 2024: Nano Letters
https://read.qxmd.com/read/38497737/a-conformational-dependent-interdomain-redox-relay-at-the-core-of-protein-disulfide-isomerase-activity
#31
JOURNAL ARTICLE
Eduardo José Xavier Rodrigues Pinho Melo, Soukaina El-Guendouz, Catia Correia, Fernando Teodoro, Carlos Lopes, Paulo J Martel
AIMS: Protein disulfide isomerases (PDIs) are a family of chaperones resident in the endoplasmic reticulum (ER). In addition to an holdase function, some members catalyse disulfide bond formation and isomerization, a crucial step for native folding and prevention of aggregation of misfolded proteins. PDIs are characterized by an arrangement of thioredoxin-like domains, with the canonical PDIA1 organized as four thioredoxin-like domains forming a horseshoe with two active sites, a and a´ , at the extremities...
March 18, 2024: Antioxidants & Redox Signaling
https://read.qxmd.com/read/38497733/increasing-access-to-behavioral-health-care-examples-of-task-shifting-in-two-u-s-government-health-care-systems
#32
JOURNAL ARTICLE
Kathryn E Kanzler, Mark E Kunik, Chase A Aycock
INTRODUCTION: Addressing U.S. health disparities in behavioral health care requires innovative solutions to expand access beyond the traditional specialty behavioral health (BH) service model. One evidence-based strategy to increase access is task shifting, whereby tasks usually reserved for licensed clinicians are delegated to less specialized but uniquely capable health workers. Health care systems in the United States have been slow to adopt this approach, despite the widespread success of task shifting in other countries...
March 18, 2024: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://read.qxmd.com/read/38497695/diagnosis-and-management-of-paroxysmal-supraventricular-tachycardia
#33
JOURNAL ARTICLE
Gary Peng, Paul C Zei
IMPORTANCE: Paroxysmal supraventricular tachycardia (PSVT), defined as tachyarrhythmias that originate from or conduct through the atria or atrioventricular node with abrupt onset, affects 168 to 332 per 100 000 individuals. Untreated PSVT is associated with adverse outcomes including high symptom burden and tachycardia-mediated cardiomyopathy. OBSERVATIONS: Approximately 50% of patients with PSVT are aged 45 to 64 years and 67.5% are female. Most common symptoms include palpitations (86%), chest discomfort (47%), and dyspnea (38%)...
February 20, 2024: JAMA
https://read.qxmd.com/read/38497683/characteristics-of-neutralizing-antibody-titers-of-the-sars-cov-2-vaccine-in-maintenance-hemodialysis-patients
#34
JOURNAL ARTICLE
Yoshifumi Amari, Satoshi Morimoto, Takashi Teranishi, Yu Motoike, Takatomi Yurugi, Yasuo Oyama, Fumitaka Nakajima, Hitoshi Kobayashi
AIMS: Hemodialysis patients have high COVID-19 severity and mortality rates. For this high-risk group of hemodialysis patients with SARS-CoV-2 infection, early SARS-CoV-2 vaccination is recommended to prevent infection and severe disease. Thus far, few reports have evaluated COVID-19 antibody titers in hemodialysis patients. In this study, we investigated the time course of antibody titers acquired by vaccination in patients on dialysis. MATERIALS AND METHODS: The anti-SARS-CoV-2 spike protein S1 IgG (anti-SP-IgG) antibody titers were compared between 33 outpatient maintenance hemodialysis patients and 32 age- and sex-matched healthy subjects...
March 18, 2024: Clinical Nephrology
https://read.qxmd.com/read/38497636/bioluminescence-resonance-energy-transfer-bret-based-assay-for-measuring-interactions-of-craf-with-14-3-3-proteins-in-live-cells
#35
JOURNAL ARTICLE
Russell Spencer-Smith
CRAF is a primary effector of RAS GTPases and plays a critical role in the tumorigenesis of several KRAS-driven cancers. In addition, CRAF is a hotspot for germline mutations, which are shown to cause the developmental RASopathy, Noonan syndrome. All RAF kinases contain multiple phosphorylation-dependent binding sites for 14-3-3 regulatory proteins. The differential binding of 14-3-3 to these sites plays essential roles in the formation of active RAF dimers at the plasma membrane under signaling conditions and in maintaining RAF autoinhibition under quiescent conditions...
March 1, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38497624/high-resolution-three-dimensional-whole-organ-tomography-of-microbial-infections
#36
JOURNAL ARTICLE
Jiagui Li, Alaa Alhayek, Heng Wang, Dirk Bumann
Most infections take place within three-dimensional host tissues with intricate anatomy and locally varying host physiology. The positioning of pathogen cells within this diverse environment significantly affects their stress levels, responses, fate, and contribution to the overall progression of the disease and treatment failure. However, due to the technical difficulties in locating µm-sized pathogen cells within cm-sized host organs, this area of research has been relatively unexplored. Here, we present a method for addressing this challenge...
March 1, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38497623/examination-of-oral-candida-infection-in-primary-sj
#37
JOURNAL ARTICLE
Xiaoyan Wang, Yeqing Song, Xinzhe Lou, Bingqing Han, Ruiqing Wu, Jing Xie, Xiang Lin, Hao Wang
Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by symptoms such as dry mouth, dry eyes, and other systematic symptoms. Due to the hyposalivation experienced by pSS patients, oral dysbacteriosis often occurs. A common complication of pSS is the oral Candida infection. In this article, the authors describe systematic methods that can effectively diagnose oral Candida infection and identify the Candida strains using saliva, oral mucosal swabs, or mouthwash from pSS patients. The Sabouraud's Dextrose Agar (SDA), hyphal formation assay, potassium hydroxide (KOH) smear test, and calcofluor white (CFW) staining assay are used for the diagnosis of oral Candida infection...
March 1, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38497618/quantitative-analysis-of-pertussis-tetanus-and-diphtheria-antibodies-in-sera-and-breast-milk-from-tdap-vaccinated-women-using-a-qualified-multiplex-assay
#38
JOURNAL ARTICLE
Susana Portillo, Jennifer Oshinsky, Margaret Williams, Sandra Yoder, Yuanyuan Liang, James D Campbell, Miriam K Laufer, Kathleen M Neuzil, Kathryn M Edwards, Marcela F Pasetti
UNLABELLED: Pertussis (whooping cough) is a reemergent, highly contagious respiratory infection of public health concern. Infants prior to initiation of their primary vaccination series are the most vulnerable to severe infection, and even death. Vaccination during pregnancy is an efficacious means of reducing infection in infants. This approach relies on boosting maternal immunity and passive transfer of antibodies to the infant via placenta and breast milk. Similarly, maternal vaccination post-partum can enhance maternal-infant immunity...
March 18, 2024: MSphere
https://read.qxmd.com/read/38497604/removal-of-heavy-metals-in-water-extracted-solution-through-adsorption-by-palygorskite-and-stabilization-by-comilling
#39
JOURNAL ARTICLE
Chang-Jung Sun, Sue-Huai Gau, Yu-Kai Huang, Ming-Guo Li, Jing Wang
Removing water-soluble chlorides (WSCs) through water extraction is a common pretreatment technology for recycling municipal solid waste incineration (MSWI) fly ash (FA). However, the extracted solution often contains heavy metals, the concentrations of which exceed standards for effluent. This study aims to investigate the adsorption of heavy metals by palygorskite in water-extracted solution and explore the feasibility of stabilizing heavy metals through comilling palygorskite-adsorbed heavy metals (PAHMs) with water-extracted fly ash (WFA)...
March 18, 2024: Waste Management & Research
https://read.qxmd.com/read/38497600/biomimetic-nanovehicle-enabled-targeted-depletion-of-intratumoral-fusobacterium-nucleatum-synergizes-with-pd-l1-blockade-against-breast-cancer
#40
JOURNAL ARTICLE
Shizhen Geng, Pengke Guo, Xinling Li, Yaru Shi, Jing Wang, Mengnian Cao, Yunya Zhang, Kaixiang Zhang, Airong Li, Haiwei Song, Zhenzhong Zhang, Jinjin Shi, Junjie Liu, Yiling Yang
Immune checkpoint blockade (ICB) therapy has been approved for breast cancer (BC), but clinical response rates are limited. Recent studies have shown that commensal microbes colonize a variety of tumors and are closely related to the host immune system response. Here, we demonstrated that Fusobacterium nucleatum ( F.n ), which is prevalent in BC, creates an immunosuppressive tumor microenvironment (ITME) characterized by a high-influx of myeloid cells that hinders ICB therapy. Administering the antibiotic metronidazole in BC can deplete F...
March 18, 2024: ACS Nano
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