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https://www.readbyqxmd.com/read/29679953/antinociception-by-the-anti-oxidized-phospholipid-antibody-e06
#1
Milad Mohammadi, Beatrice Oehler, Jan Kloka, Corinna Martin, Alexander Brack, Robert Blum, Heike L Rittner
BACKGROUND AND PURPOSE: Reactive oxygen species (ROS) and their downstream molecules such as oxidized phospholipids (OxPL) and 4-hydroxynonenal (4-HNE) activate transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) ion channels in vivo and in vitro shaping thermal and mechanical hypersensitivity in inflammatory pain. E06/T15 is a monoclonal autoantibody against oxidized phosphatidylcholine (OxPC) used in diagnostics in arteriosclerosis. Recently, we provided evidence that E06 also ameliorates inflammatory pain...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679952/injuries-to-cyclists-due-to-a-dog-bicycle-interaction
#2
Randall T Loder, Alan P Yaacoub
BACKGROUND:  Both dogs and bicycles are common in our society and thus a dog-bicycle interaction resulting in an injury to a cyclist is possible. It was the purpose of this study to investigate such injuries. METHODS:  The National Electronic Injury Surveillance System (NEISS) data for the 10-year period from 2006 through 2015 associated with bicycles were accessed. Injuries involving dogs were identified and the mechanism of injury determined. Due to the stratified and weighted nature of the NEISS data, statistical analyses were performed with SUDAAN 10 software (RTI International, Research Triangle Park, North Carolina, United States)...
April 21, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29679933/slip-avoidance-strategies-in-children-with-bilateral-spastic-cerebral-palsy-and-crouch-gait
#3
Ana Francisca Rozin Kleiner, Ilaria Pacifici, Claudia Condoluci, Chiarella Sforza, Manuela Galli
BACKGROUND: A slip occurs when the required friction (RCOF) to prevent slipping at the foot/floor interfaces exceeds the available friction. The RCOF is dependent upon the biomechanics features of individuals and their gait. On the other hand, the available friction depends on environmental features. Once individuals with crouch gait have their biomechanics of gait completely altered, how do they interact with a supporting surface? The aim was to quantify the RCOF in children with bilateral spastic cerebral palsy (BSCP) and crouch gait...
April 11, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29679925/tocotrienol-rich-fraction-supplementation-reduces-hyperglycemia-induced-skeletal-muscle-damage-through-regulation-of-insulin-signaling-and-oxidative-stress-in-type-2-diabetic-mice
#4
Heaji Lee, Yunsook Lim
Chronic hyperglycemia induces impairment of muscle growth and development of diabetes mellitus (DM). Since skeletal muscle is the major site for disposal of ingested glucose, impaired glucose metabolism causes imbalance between protein synthesis and degradation which adversely affects physical mobility. In this study, we investigated the effect of tocotrienol-rich fraction (TRF) supplementation on skeletal muscle damage in diabetic mice. Diabetes was induced by a high-fat diet with streptozotocin (STZ) injection (100 mg/kg) in male C57BL/6J mice...
March 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29679909/mechanisms-of-the-active-components-from-korean-pine-nut-preventing-and-treating-d-galactose-induced-aging-rats
#5
Jianmei Zhang, Weiwei Lin, Ruijun Wu, Yanmeng Liu, Kai Zhu, Jinyu Ren, Sufang Zhang, Xiaomei Ling
Age-related neuronal injury and oxidative damage are the predominant factors for neurodegenerative diseases like Alzheimer's disease (AD). The aim of this study was to explore whether chronic administration of d-galactose (d-gal) can cause neuronal injury and oxidative damage, and to investigate the neuroprotective and antioxidative effects of the active components (UPNO-1) from Korean pine nut (Pinus koraiensis). Two dosing regimens were designed, one for the evaluation of preventive effects in which the rats were simultaneously administrated d-gal and UPNO-1/fishoil for 12 weeks, the other for the evaluation of therapeutic effects in which the rats were given d-gal for 8 weeks before treated with UPNO-1/selegiline for 8 weeks...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679901/replacement-of-arg-with-nle-and-modified-d-phe-in-the-core-sequence-of-mshs-ac-his-d-phe-arg-trp-nh-2-leads-to-hmc1r-selectivity-and-pigmentation
#6
Saghar Mowlazadeh Haghighi, Yang Zhou, Jixun Dai, Jonathon R Sawyer, Victor J Hruby, Minying Cai
Melanoma skin cancer is the fastest growing cancer in the US [1]. A great need exists for improved formulations and mechanisms to prevent and protect human skin from cancers and other skin damage caused by sunlight exposure. Current efforts to prevent UV damage to human skin, which in many cases leads to melanoma and other skin cancers. The primordial melanocortin-1 receptor (MC1R) is involved in regulating skin pigmentation and hair color, which is a natural prevention from UV damage. The endogenous melanocortin agonists induce pigmentation and share a core pharmacophore sequence "His-Phe-Arg-Trp", and it was found that substitution of the Phe by D-Phe results in increasing melanocortin receptor potency...
April 11, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29679898/heart-rate-variability-alterations-in-late-life-depression-a-meta-analysis
#7
REVIEW
Lydia Brown, Chandan Karmakar, Richard Gray, Ripu Jindal, Terrence Lim, Christina Bryant
OBJECTIVE: There is strong evidence for a bi-directional relationship between heart-health and depression in later life, but the physiological mechanisms underlying this relationship remain unclear. Heart rate variability is one promising factor that might help explain this relationship. We present results of a meta-analysis that considers heart rate variability alterations in older adults with depression. METHODS: Literature search of Embase, PsychInfo and Medline revealed five clinical studies and six observational studies that examined the relationship between heart rate variability and depression in adults with a mean age over 60...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679896/treatment-as-usual-tau-as-a-control-condition-in-trials-of-cognitive-behavioural-based-psychotherapy-for-self-harm-impact-of-content-and-quality-on-outcomes-in-a-systematic-review
#8
REVIEW
Katrina Witt, Daniela Pache de Moraes, Tatiana Taylor Salisbury, Ella Aren S Man, David Gunnell, Philip Hazell, Ellen Townsend, Kees van Heeringen, Keith Hawton
BACKGROUND: Randomized controlled trials (RCTs) are the mainstay of evaluations of the efficacy of psychosocial interventions. In a recent Cochrane systematic review we analysed the efficacy of cognitive behavioural-based psychotherapies compared to treatment as usual (TAU) in adults who self-harm. In this study we examine the content and reporting quality of TAU in these trials and their relationship to outcomes. METHODS: Five electronic databases (CCDANCTR-Studies and References, CENTRAL, MEDLINE, EMBASE, and PsycINFO) were searched for RCTs, indexed between 1 January 1998 and 30 April 2015, of cognitive-behavioural interventions compared to TAU for adults following a recent (within six months) episode of self-harm...
April 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679894/nicotinamide-riboside-attenuates-alcohol-induced-liver-injuries-via-activation-of-sirt1-pgc-1%C3%AE-mitochondrial-biosynthesis-pathway
#9
Sufan Wang, Ting Wan, Mingtong Ye, Yun Qiu, Lei Pei, Rui Jiang, Nengzhi Pang, Yuanling Huang, Baoxia Liang, Wenhua Ling, Xiaojun Lin, Zhenfeng Zhang, Lili Yang
BACKGROUND: Nicotinamide riboside (NR) is a nicotinamide adenine dinucleotide (NAD+ ) precursor which is present in foods such as milk and beer. It was reported that NR can prevent obesity, increase longevity, and promote liver regeneration. However, whether NR can prevent ethanol-induced liver injuries is not known. This study aimed to explore the effect of NR on ethanol induced liver injuries and the underlying mechanisms. METHODS: We fed C57BL/6 J mice with Lieber-DeCarli ethanol liquid diet with or without 400 mg/kg·bw NR for 16 days...
April 5, 2018: Redox Biology
https://www.readbyqxmd.com/read/29679862/a-small-scale-study-investigating-staff-and-student-perceptions-of-the-barriers-to-a-preventative-approach-for-adolescent-self-harm-in-secondary-schools-in-wales-a-grounded-theory-model-of-stigma
#10
Rachel Parker
OBJECTIVES: Grounded theory analysis of secondary school staff and pupil perceptions about the barriers to preventative work for adolescent self-harm within the secondary school setting in Wales. STUDY DESIGN: Qualitative and grounded theory. METHODS: Two secondary schools in Wales were purposefully sampled for variation. Four group interviews took place using qualitative research methods (Participatory Rapid Appraisal) with six school-based professionals and six students aged more than 16 years...
April 18, 2018: Public Health
https://www.readbyqxmd.com/read/29679852/accident-analysis-to-support-the-development-of-strategies-for-the-prevention-of-brain-injuries-in-car-crashes
#11
Jacobo Antona-Makoshi, Koji Mikami, Mats Lindkvist, Johan Davidsson, Sylvia Schick
This study estimated the frequency and risk of Moderate-to-Maximal traumatic brain injuries sustained by occupants in motor vehicle crashes in the US. National Automotive Sampling System - Crashworthiness Data System crashes that occurred in years 2001-2015 with light vehicles produced 2001 or later were incorporated in the study. Crash type, crash severity, car model year, belt usage and occupant age and sex were controlled for in the analysis. The results showed that Moderate concussions account for 79% of all MAISbrain 2+ injuries...
April 18, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29679844/measuring-impairment-when-diagnosing-adolescent-adhd-differentiating-problems-due-to-adhd-versus-other-sources
#12
Alejandro L Vazquez, Margaret H Sibley, Mileini Campez
The DSM-5 requires clinicians to link ADHD symptoms to clinically meaningful impairments in daily life functioning. Measuring impairment during ADHD assessments may be particularly challenging in adolescence, when ADHD is often not the sole source of a youth's difficulties. Existing impairment rating scales are criticized for not specifying ADHD as the source of impairment in their instructions, leading to potential problems with rating scale specificity. The current study utilized a within subjects design (N = 107) to compare parent report of impairment on two versions of a global impairment measure: one that specified ADHD as the source of impairment (Impairment Rating Scale-ADHD) and a standard version that did not (Impairment Rating Scale)...
April 13, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29679836/physical-immobility-as-a-sensitive-indicator-of-hydraulic-fracturing-fluid-toxicity-towards-daphnia-magna
#13
Tamzin A Blewett, Perrine L M Delompré, Chris N Glover, Greg G Goss
The process of extracting hydrocarbon resources by hydraulic fracturing is an increasingly utilised technique worldwide, resulting in an effluent called flowback and produced water (FPW). This effluent is a complex mixture of salts, metals and organic compounds, and has been shown to be highly toxic to aquatic biota, an effect attributed mainly to its salt and organic components. However, in the current study we show that the water flea, Daphnia magna, is physically impaired by, and rendered immobile at the surface of, test waters containing FPW...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679825/technologies-for-the-management-of-msw-incineration-ashes-from-gas-cleaning-new-perspectives-on-recovery-of-secondary-raw-materials-and-circular-economy
#14
REVIEW
Margarida J Quina, Elza Bontempi, Anna Bogush, Stefan Schlumberger, Gisela Weibel, Roberto Braga, Valerio Funari, Jiri Hyks, Erik Rasmussen, Jakob Lederer
Environmental policies in the European Union focus on the prevention of hazardous waste and aim to mitigate its impact on human health and ecosystems. However, progress is promoting a shift in perspective from environmental impacts to resource recovery. Municipal solid waste incineration (MSWI) has been increasing in developed countries, thus the amount of air pollution control residues (APCr) and fly ashes (FA) have followed the same upward trend. APCr from MSWI is classified as hazardous waste in the List of Waste (LoW) and as an absolute entry (19 01 07*), but FA may be classified as a mirror entry (19 0 13*/19 01 14)...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679810/the-cost-effectiveness-of-seven-behavioural-interventions-to-prevent-drug-misuse-in-vulnerable-populations
#15
Becky Pennington, Brendan Collins, Simon Leigh, Antony P Martin, Lesley Owen, Alastair Fischer, Harry Sumnall, Geoff Bates
BACKGROUND: The National Institute for Health and Care Excellence (NICE) developed a guideline on drug misuse prevention in vulnerable populations. Part of the guideline development process involved evaluating cost-effectiveness and determining which interventions represented good value for money. METHODS: Economic models were developed for seven interventions which aimed to prevent drug use in vulnerable populations. The models compared the costs (to the health and crime sectors) and health benefits (in quality-adjusted life years (QALYs)) of each intervention and its comparator...
April 18, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29679791/phosphorodiamidate-morpholino-targeting-the-5-untranslated-region-of-the-zikv-rna-inhibits-virus-replication
#16
Waldemar Popik, Atanu Khatua, James E K Hildreth, Benjamin Lee, Donald J Alcendor
BACKGROUND: Zika virus (ZIKV) infection has been associated with microcephaly in infants. Currently there is no treatment or vaccine. Here we explore the use of a morpholino oligonucleotide targeted to the 5' untranslated region (5'-UTR) of the ZIKV RNA to prevent ZIKV replication. METHODS: Morpholino DWK-1 inhibition of ZIKV replication in human glomerular podocytes was examined by qRT-PCR, reduction in ZIKV genome copy number, western blot analysis, immunofluorescence and proinflammatory cytokine gene expression...
April 18, 2018: Virology
https://www.readbyqxmd.com/read/29679754/serum-25-hydroxyvitamin-d-and-breast-cancer-risk-by-pathological-subtype-mcc-spain
#17
Virginia Lope, Adela Castelló, Antonio Mena-Bravo, Pilar Amiano, Nuria Aragonés, Tania Fernández-Villa, Marcela Guevara, Trinidad Dierssen-Sotos, Guillermo Fernandez-Tardón, Gemma Castaño-Vinyals, Rafael Marcos-Gragera, Víctor Moreno, Dolores Salas-Trejo, Marian Diaz-Santos, Madalen Oribe, Isabel Romieu, Manolis Kogevinas, Feliciano Priego-Capote, Beatriz Pérez-Gómez, Marina Pollán
Epidemiologic evidence on the association between vitamin D and breast cancer is still inconclusive. This study analyzes the association between serum 25-hydroxyvitamin D (25(OH)D) and breast cancer risk by pathologic subtype, stage at diagnosis and specific breast cancer risk factors. We conducted a population-based multicase-control study where 546 histologically-confirmed breast cancer cases and 558 population controls, frequently matched by geographic area, age and body mass index, were recruited in 12 Spanish provinces (MCC-Spain)...
April 18, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29679742/adaptive-thermogenesis-by-dietary-n-3-polyunsaturated-fatty-acids-emerging-evidence-and-mechanisms
#18
REVIEW
Rong Fan, Karsten Koehler, Soonkyu Chung
Brown/beige fat plays a crucial role in maintaining energy homeostasis through non-shivering thermogenesis in response to cold temperature and excess nutrition (adaptive thermogenesis). Although numerous molecular and genetic regulators have been identified, relatively little information is available regarding thermogenic dietary molecules. Recently, a growing body of evidence suggests that high consumption of n-3 polyunsaturated fatty acids (PUFA) or activation of GPR120, a membrane receptor of n-3 PUFA, stimulate adaptive thermogenesis...
April 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29679739/accidental-displacement-of-mandibular-first-molar-root-into-buccal-space-a-unique-case
#19
Anuj Jain
A few cases of accidental displacement of mandibular molar or fragment of tooth into adjacent anatomical spaces, during surgical interventions have been reported. This report describes a unique case of swelling with extra oral skin fistula in mandibular body region caused by unrecognized displacement of a lower first molar root into buccal space. The possible causes for such incident along with the complications which may occur and the techniques used to prevent the risk of accidental displacement of teeth and roots, during extraction are discussed...
April 18, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29679733/il-6-trans-signalling-mediates-trabecular-but-not-cortical-bone-loss-after-ovariectomy
#20
Leah Lazzaro, Brett A Tonkin, Ingrid J Poulton, Narelle E McGregor, Walter Ferlin, Natalie A Sims
Bone loss associated with estrogen deficiency occurs due to a high level of bone remodelling, with a greater increase in the level of osteoclast-mediated bone resorption than osteoblast-mediated bone formation. Early studies showed that Interleukin-6 (IL-6) inhibition could prevent the increase in osteoclast numbers associated with ovariectomy. However, IL-6 signals through two possible pathways: classic IL-6 signalling (cis) utilizes a membrane-bound IL-6 receptor (IL-6R), while IL-6 trans-signalling occurs through a soluble IL-6R (sIL-6R)...
April 18, 2018: Bone
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