keyword
https://read.qxmd.com/read/38493435/androgen-deprivation-therapy-related-fracture-risk-in-prostate-cancer-an-insurance-claims-database-study-in-japan
#1
JOURNAL ARTICLE
Hisashi Matsushima, Tetsuya Taguchi, Sho Kodama, Naoki Okubo, Kengo Saito, Katarzyna Jabłońska, Seiji Fukumoto, Toshio Matsumoto
INTRODUCTION: Androgen deprivation therapy (ADT) is widely used for the treatment of prostate cancer. ADT is associated with reduced bone density leading to an increased risk of osteoporotic fracture. The objective of this retrospective cohort study was to quantify fracture risk in men treated with ADT for prostate cancer in real-world practice in Japan. MATERIALS AND METHODS: Data were extracted from the Japanese Medical Data Vision (MDV) database. Men initiating ADT for treatment of prostate cancer between April 2010 and March 2021 were identified and matched to a cohort of prostate cancer patients not taking ADT using a propensity score...
March 17, 2024: Journal of Bone and Mineral Metabolism
https://read.qxmd.com/read/38493431/evaluation-of-the-protective-and-therapeutic-effects-of-extra-virgin-olive-oil-rich-in-phenol-in-experimental-model-of-neonatal-necrotizing-enterocolitis-by-clinical-disease-score-%C3%A4-nflammation-apoptosis-and-oxidative-stress-markers
#2
JOURNAL ARTICLE
Mustafa Tuşat, Recep Eroz, Ferhan Bölükbaş, Erkan Özkan, Hüseyin Erdal
BACKGROUND AND AIM: Necrotizing Enterocolitis (NEC) is an inflammation-associated ischemic necrosis of the intestine. To investigate the effects of extra virgin olive oil (EVOO) on inflammation, oxidative stress, apoptosis, and histological changes in NEC-induced newborn rats. MATERIALS AND METHODS: 24 rats were randomly divided into three groups: control, NEC and NEC + EVOO. NEC induction was performed using hypoxia-hyperoxia, formula feeding, and cold stress...
March 17, 2024: Pediatric Surgery International
https://read.qxmd.com/read/38493418/intrauterine-interventions-options-for-preventing-recurrence-after-hysteroscopic-adhesiolysis-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#3
REVIEW
Ruonan Tang, Wanlin Zhang, Xifeng Xiao, Wenyi Li, Xinxin Chen, Xiaohong Wang
PURPOSE: Recurrence of adhesions after hysteroscopic adhesiolysis is a challenging clinical problem without a unified management approach. Therefore, we conducted a network meta-analysis that considered both direct and indirect comparisons between interventions to identify optimal strategies for preventing recurrence. METHODS: We searched for research trials published up to July 2023 from PubMed, Embase and the Cochrane Database. We selected randomized controlled trials comparing the use of different interventions for the prevention of adhesion recurrence, with no language or regional restrictions...
March 17, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38493411/modelling-the-public-health-burden-of-herpes-zoster-and-the-impact-of-adjuvanted-recombinant-zoster-vaccine-in-five-selected-countries-in-southeast-asia
#4
JOURNAL ARTICLE
Ru Han, Peter San Martin, Nurilign Ahmed, Adriana Guzman-Holst, Ahmed Mohy, Thatiana Pinto, Bruna de Veras, Jorge A Gomez, Gyneth Lourdes Bibera, Désirée A M van Oorschot
INTRODUCTION: Herpes zoster (HZ) can cause substantial patient morbidity and lead to large healthcare costs. However, the disease burden of HZ in Southeast Asia may be underestimated. This study aimed to estimate the public health burden of HZ and the impact of vaccinating adults aged ≥ 50 years old in five Southeast Asian countries (Indonesia, Malaysia, Philippines, Thailand, and Vietnam), with adjuvanted recombinant zoster vaccine (RZV) compared with no vaccination...
March 17, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38493408/a-novel-mitochondrial-unfolded-protein-response-related-risk-signature-to-predict-prognosis-immunotherapy-and-sorafenib-sensitivity-in-hepatocellular-carcinoma
#5
JOURNAL ARTICLE
Sidi Zhang, Hanyao Guo, Hongyu Wang, Xiaopeng Liu, Meixia Wang, Xiaoyu Liu, Yumei Fan, Ke Tan
Hepatocellular carcinoma (HCC) is a common cause of cancer-associated death worldwide. The mitochondrial unfolded protein response (UPRmt ) not only maintains mitochondrial integrity but also regulates cancer progression and drug resistance. However, no study has used the UPRmt to construct a prognostic signature for HCC. This work aimed to establish a novel signature for predicting patient prognosis, immune cell infiltration, immunotherapy, and chemotherapy response based on UPRmt -related genes (MRGs). Transcriptional profiles and clinical information were obtained from the TCGA and ICGC databases...
March 17, 2024: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/38493401/who-benefits-and-how-five-dimensions-of-adolescent-psychological-well-being-and-their-relative-impact-on-cardiometabolic-health-in-adulthood
#6
JOURNAL ARTICLE
Farah Qureshi, Anne-Josee Guimond, Scott Delaney, Julia K Boehm, Laura D Kubzansky
PURPOSE: Positive dimensions of psychological well-being in adolescence may help youth preserve cardiometabolic health (CMH) as they age, but little is known about which aspects of well-being matter most and for whom. This study examines the differential impact of five dimensions of adolescent psychological well-being on CMH maintenance in adulthood and considers social patterning in both their distribution and respective health benefits. METHODS: Data were from the National Longitudinal Study of Adolescent Health (N = 3,464), five dimensions of psychological well-being were identified at baseline (1994-1995; mean age = 15 years): happiness, optimism, self-esteem, belonging, and feeling loved...
March 14, 2024: Journal of Adolescent Health
https://read.qxmd.com/read/38493398/early-drinking-onset-and-subsequent-alcohol-use-in-late-adolescence-a-longitudinal-study-of-drinking-patterns
#7
JOURNAL ARTICLE
Lars Sjödin, Jonas Raninen, Peter Larm
PURPOSE: The age of drinking onset is a central concept for both policy and prevention of alcohol-related harm, yet evidence on the predictive value of the age of onset is lacking. This study compares alcohol outcomes of adolescents who started to drink early with those who started later, and tests if associations are moderated by other explanatory factors. METHODS: Data from a two-wave longitudinal prospective cohort survey with a Swedish nationwide sample of 4,018 adolescents aged 15/16 years at baseline (T1) and 17/18 years at follow-up (T2) were used...
March 14, 2024: Journal of Adolescent Health
https://read.qxmd.com/read/38493392/parent-child-associations-in-covid-19-related-preventive-behaviors-and-efficacy-expectations-a-one-year-longitudinal-survey
#8
JOURNAL ARTICLE
Shinya Yoshino, Wai Him Crystal Law, Shinsuke Koike
PURPOSE: It is necessary to identify the variables that explain the variance in preventive behaviors against COVID-19 to increase adolescents' engagement in these behaviors. We focused on efficacy expectations of preventive behaviors and their associations within families. This study examined the associations between efficacy expectations and preventive behaviors, and between adolescents and their parents in terms of efficacy expectations and preventive behaviors. METHODS: A cross-lagged panel model was employed to analyze 281 parent-child pairs consisting of 245 children (118 girls, mean age = 17...
March 15, 2024: Journal of Adolescent Health
https://read.qxmd.com/read/38493376/national-institute-on-drug-abuse-clinical-trials-network-meeting-report-managing-patients-exposed-to-xylazine-adulterated-opioids-in-emergency-hospital-and-addiction-care-settings
#9
REVIEW
Jeanmarie Perrone, Rachel Haroz, Joseph D'Orazio, Giacomo Gianotti, Jennifer Love, Matthew Salzman, Margaret Lowenstein, Ashish Thakrar, Stephanie Klipp, Lisa Rae, Megan K Reed, Edward Sisco, Rachel Wightman, Lewis S Nelson
Used as a veterinary sedative and not approved for human use, xylazine has been increasingly linked with opioid overdose deaths in the United States. A growing number of people have been exposed to xylazine in the illicit opioid supply (especially fentanyl) or in other drugs, particularly in some areas of the Northeast. Xylazine is an α-2 adrenergic agonist that decreases sympathetic nervous system activity. When combined with fentanyl or heroin, it is purported to extend the duration of the opioid's sedative effect and to cause dependence and an associated withdrawal syndrome; however, data to support these concerns are limited...
March 15, 2024: Annals of Emergency Medicine
https://read.qxmd.com/read/38493353/first-implantable-cardiac-defibrillator-insertions-in-new-south-wales-2005-2020-an-analysis-of-linked-administrative-data
#10
JOURNAL ARTICLE
Lin Zhu, Andrew Hayen, Bianca Blanch, Nathan Engstrom, Jenny A Doust, Christopher Semsarian, Katy Jl Bell
OBJECTIVES: To determine the annual numbers of first ICD insertions in New South Wales during 2005-2020; to examine health outcomes for people who first received ICDs during this period. STUDY DESIGN: Retrospective cohort study; analysis of linked administrative health data. SETTING, PARTICIPANTS: All first insertions of ICDs in NSW, 2005-2020. MAIN OUTCOME MEASURES: Annual numbers of first ICD insertions, and of emergency department presentations and hospital re-admissions 30 days, 90 days, 365 days after first ICD insertions; all-cause and disease-specific mortality (to ten years after ICD insertion)...
March 18, 2024: Medical Journal of Australia
https://read.qxmd.com/read/38493340/translational-bioinformatics-and-data-science-for-biomarker-discovery-in-mental-health-an-analytical-review
#11
JOURNAL ARTICLE
Krithika Bhuvaneshwar, Yuriy Gusev
Translational bioinformatics and data science play a crucial role in biomarker discovery as it enables translational research and helps to bridge the gap between the bench research and the bedside clinical applications. Thanks to newer and faster molecular profiling technologies and reducing costs, there are many opportunities for researchers to explore the molecular and physiological mechanisms of diseases. Biomarker discovery enables researchers to better characterize patients, enables early detection and intervention/prevention and predicts treatment responses...
January 22, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38493313/defect-passivation-of-2d-semiconductors-by-fixating-chemisorbed-oxygen-molecules-via-h-bn-encapsulations
#12
JOURNAL ARTICLE
Jin-Woo Jung, Hyeon-Seo Choi, Young-Jun Lee, Youngjae Kim, Takashi Taniguchi, Kenji Watanabe, Min-Yeong Choi, Jae Hyuck Jang, Hee-Suk Chung, Dohun Kim, Youngwook Kim, Chang-Hee Cho
Hexagonal boron nitride (h-BN) is a key ingredient for various 2D van der Waals heterostructure devices, but the exact role of h-BN encapsulation in relation to the internal defects of 2D semiconductors remains unclear. Here, it is reported that h-BN encapsulation greatly removes the defect-related gap states by stabilizing the chemisorbed oxygen molecules onto the defects of monolayer WS2 crystals. Electron energy loss spectroscopy (EELS) combined with theoretical analysis clearly confirms that the oxygen molecules are chemisorbed onto the defects of WS2 crystals and are fixated by h-BN encapsulation, with excluding a possibility of oxygen molecules trapped in bubbles or wrinkles formed at the interface between WS2 and h-BN...
March 17, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38493311/tuning-the-properties-of-multi-stable-structures-post-fabrication-via-the-two-way-shape-memory-polymer-effect
#13
JOURNAL ARTICLE
Giada Risso, Max Kudisch, Paolo Ermanni, Chiara Daraio
Multi-stable elements are commonly employed to design reconfigurable and adaptive structures, because they enable large and reversible shape changes in response to changing loads, while simultaneously allowing self-locking capabilities. However, existing multi-stable structures have properties that depend on their initial design and cannot be tailored post-fabrication. Here, a novel design approach is presented that combines multi-stable structures with two-way shape memory polymers. By leveraging both the one-way and two-way shape memory effect under bi-axial strain conditions, the structures can re-program their 3D shape, bear loads, and self-actuate...
March 17, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38493295/capitate-proximal-fragment-migration-compressing-the-median-nerve-in-scaphocapitate-fracture-a-case-report
#14
JOURNAL ARTICLE
Vasileios Giannatos, Theodoros Stavropoulos, Charalampos Charalampous-Kefalas, Panagiotis Antzoulas, Andreas Panagopoulos, Zinon Kokkalis
BACKGROUND Scaphocapitate syndrome is a rare clinical entity consisting of a combined scaphoid and capitate fracture along with a 90- or 180-degrees rotation of the proximal capitate fragment. The syndrome is scarcely described in the literature, with proximal migration of the capitate fragment being reported only by Mudgal et al in 1995. Concurrent compression of the median nerve is a highly unfortunate event, suggesting a unique case presented here. CASE REPORT We present a unique case of scaphocapitate fracture-dislocation in a 25-year-old man with volar dislocation of the capitate's fragment deep to the median nerve...
March 17, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38493291/downregulation-of-hmgb1-carried-by-macrophage-derived-extracellular-vesicles-delays-atherosclerotic-plaque-formation-through-caspase-11-dependent-macrophage-pyroptosis
#15
JOURNAL ARTICLE
Weijie Liang, Ruibin Wei, Xingxing Zhu, Jinliang Li, Aiwen Lin, Jun Chen, Wen Wu, Qiang Jie
BACKGROUND: Macrophage-derived extracellular vesicle (macrophage-EV) is highly studied for its regulatory role in atherosclerosis (AS). Our current study tried to elucidate the possible role of macrophage-EV loaded with small interfering RNA against high-mobility group box 1 (siHMGB1) affecting atherosclerotic plaque formation. METHODS: In silico analysis was performed to find critical factors in mouse atherosclerotic plaque formation. EVs secreted by RAW 264.7 cells were collected by ultracentrifugation and characterized, followed by the preparation of macrophage-EV-loaded siHMGB1 (macrophage-EV/siHMGB1)...
March 16, 2024: Molecular Medicine
https://read.qxmd.com/read/38493287/telomere-length-as-biomarker-of-nutritional-therapy-for-prevention-of-type-2-diabetes-mellitus-development-in-patients-with-coronary-heart-disease-cordioprev-randomised-controlled-trial
#16
JOURNAL ARTICLE
Ana Ojeda-Rodriguez, Oriol A Rangel-Zuñiga, Antonio P Arenas-de Larriva, Francisco M Gutierrez-Mariscal, Jose D Torres-Peña, Juan L Romero-Cabrera, Alicia Podadera-Herreros, Helena García-Fernandez, Esther Porras-Pérez, Raul M Luque, Stefanos N Kales, Pablo Perez-Martinez, Javier Delgado-Lista, Elena M Yubero-Serrano, Jose Lopez-Miranda
BACKGROUND: Telomere Length (TL), a marker of cellular aging, holds promise as a biomarker to elucidate the molecular mechanism of diabetes. This study aimed to investigate whether shorter telomeres are associated with a higher risk of type 2 diabetes mellitus (T2DM) incidence in patients with coronary heart disease; and to determine whether the most suitable dietary patterns, particularly a Mediterranean diet or a low-fat diet, can mitigate the development of diabetes in these patients after a follow-up period of five years...
March 16, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38493278/sex-differences-in-modifiable-risk-factors-for-stroke-incidence-and-recurrence-the-ucc-smart-study
#17
JOURNAL ARTICLE
Ina Rissanen, Maartje Basten, Lieza G Exalto, Sanne A E Peters, Frank L J Visseren, Mirjam I Geerlings
BACKGROUND AND PURPOSE: Risk factors for stroke differ between women and men in general populations. However, little is known about sex differences in secondary prevention. We investigated if sex interacted with modifiable risk factors for stroke in a large arterial disease cohort. METHODS: Within the prospective UCC-SMART study, 13,898 patients (35% women) with atherosclerotic disease or high-risk factor profile were followed up to 23 years for stroke incidence or recurrence...
March 16, 2024: Journal of Neurology
https://read.qxmd.com/read/38493274/low-dose-aspirin-use-does-not-increase-disease-activity-in-pregnant-patients-with-inflammatory-bowel-disease
#18
JOURNAL ARTICLE
Chelsea A DeBolt, Zoë S Gottlieb, Manasa G Rao, Shaelyn Johnson, Patricia Rekawek, Richa Deshpande, Rachel Meislin, Jill Berkin, Angela Bianco, Maria Teresa Mella, Marla C Dubinsky
BACKGROUND: The adverse effects of non-steroidal anti-inflammatory (NSAID) drugs on the gastrointestinal system are well recognized, but the effect of NSAID use on disease activity patients with inflammatory bowel disease (IBD) remains unresolved. Low-dose aspirin (LDA) is recommended for all pregnant patients with risk factors for developing preeclampsia, including autoimmune conditions. As recognition of risk factors for preeclampsia improves, the preventative use of LDA is likely to increase...
March 16, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38493258/state-of-the-art-mobile-head-ct-scanner-delivers-nearly-the-same-image-quality-as-a-conventional-stationary-ct-scanner
#19
JOURNAL ARTICLE
Lukas Goertz, Yosef Al-Sewaidi, Mahmoud Habib, David Zopfs, Benjamin Reichardt, Alexander Ranft, Christoph Kabbasch
The use of mobile head CT scanners in the neurointensive care unit (NICU) saves time for patients and NICU staff and can reduce transport-related mishaps, but the reduced image quality of previous mobile scanners has prevented their widespread clinical use. This study compares the image quality of SOMATOM On.Site (Siemens Healthineers, Erlangen, Germany), a state-of-the-art mobile head CT scanner, and a conventional 64-slice stationary CT scanner. The study included 40 patients who underwent head scans with both mobile and stationary scanners...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38493254/modeling-and-analysis-of-the-effect-of-optimal-virus-control-on-the-spread-of-hfmd
#20
JOURNAL ARTICLE
Hui Wang, Weihua Li, Lei Shi, Gaofang Chen, Zhengwen Tu
A within-host and between-host hand, foot and mouth disease (HFMD) mathematical model is established and the affect of optimal control in its within-host part on HFMD transmission is studied. Through define two basic reproduction numbers, by using the fast-slow system analysis method of time scale, the global stabilities of the between-host (slow) system and within-host (fast) system are researched, respectively. An optimal control problem with drug-treatment control on coupled within-host and between-host HFMD model is formulated and analysed theoretically...
March 16, 2024: Scientific Reports
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