Xuewen Chen, Augustinus G Haribowo, Alan H Baik, Andrea Fossati, Erica Stevenson, Yiwen R Chen, Nabora S Reyes, Tien Peng, Michael A Matthay, Michela Traglia, Alexander R Pico, Daniel F Jarosz, Abigail Buchwalter, Sina Ghaemmaghami, Danielle L Swaney, Isha H Jain
Oxygen deprivation and excess are both toxic. Thus, the body's ability to adapt to varying oxygen tensions is critical for survival. While the hypoxia transcriptional response has been well studied, the post-translational effects of oxygen have been underexplored. In this study, we systematically investigate protein turnover rates in mouse heart, lung, and brain under different inhaled oxygen tensions. We find that the lung proteome is the most responsive to varying oxygen tensions. In particular, several extracellular matrix (ECM) proteins are stabilized in the lung under both hypoxia and hyperoxia...
December 8, 2023: Science Advances