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effects of hyperoxia in body

Connie C W Hsia, Priya Ravikumar, Jianfeng Ye
The lung interfaces with atmospheric oxygen via a large surface area and is perfused by the entire venous return bearing waste products collected from the entire body. It is logical that the lung is endowed with generous anti-oxidative capacity derived both locally and from the circulation. The single-pass pleiotropic alpha-Klotho (αKlotho) protein was discovered when its genetic disruption led to premature multi-organ degeneration and early death. The extracellular domain of αKlotho is cleaved by secretases and released into circulation as endocrine soluble αKlotho protein and exerting wide-ranging cytoprotective effects including anti-oxidation on distant organs especially the lung, which exhibits high sensitivity to circulating αKlotho insufficiency...
March 24, 2017: Bone
E M J Durlinger, A M E Spoelstra-de Man, B Smit, H J de Grooth, A R J Girbes, H M Oudemans-van Straaten, Y M Smulders
BACKGROUND: Concerns have been expressed regarding a possible association between arterial hyperoxia and adverse outcomes in critically ill patients. Oxygen status is commonly monitored noninvasively by peripheral saturation monitoring (SpO2). However, the risk of hyperoxia above specific SpO2 levels in critically ill patients is unknown. The purpose of this study was to determine a threshold value of SpO2 above which the prevalence of arterial hyperoxia distinctly increases. METHODS: This is a cross-sectional study in adult mechanically ventilated intensive care patients in a tertiary referral center...
March 2, 2017: Journal of Critical Care
Bryan Leaw, Dandan Zhu, Jean Tan, Ruth Muljadi, Mohamed I Saad, Joanne C Mockler, Euan M Wallace, Rebecca Lim, Mary Tolcos
BACKGROUND: Human amnion epithelial cells (hAECs) are clonogenic and have been proposed to reduce inflammatory-induced tissue injury. Perturbation of the immune response is implicated in the pathogenesis of perinatal brain injury; modulating this response could thus be a novel therapy for treating or preventing such injury. The immunomodulatory properties of hAECs have been shown in other animal models, but a detailed investigation of the effects on brain immune cells following injury has not been undertaken...
February 28, 2017: Stem Cell Research & Therapy
Philipp Rath, Claudio Nardiello, David E Surate Solaligue, Ronald Agius, Ivana Mižíková, Sebastian Hühn, Konstantin Mayer, István Vadász, Susanne Herold, Frank Runkel, Werner Seeger, Rory E Morty
BACKGROUND: Caffeine is widely used to manage apnea of prematurity, and reduces the incidence of bronchopulmonary dysplasia (BPD). Deregulated transforming growth factor (TGF)-β signaling underlies arrested post-natal lung maturation in BPD. It is unclear whether caffeine impacts TGF-β signaling or post-natal lung development in affected lungs. METHODS: The impact of caffeine on TGF-β signaling in primary mouse lung fibroblasts and alveolar epithelial type II cells was assessed in vitro...
January 31, 2017: Pediatric Research
Li Yuan, Xiuxiang Liu, Ruiwei Gao, Jinshuai Ma, Suni Lu, Haihong Zhang
Objective To study the protective effect of interleukin-22 (IL-22) against the hyperoxia-induced lung injury in neonatal SD rats. Methods The neonatal SD rats were randomized into control group, hyperoxia group and IL-22 (10 ng/g) treatment group. Each group was randomly divided into three subgroups of 1, 3, 7 days (n=9). Body mass in every group was detected; lung pathological changes were observed by HE staining; tumor necrosis factor α (TNF-α) in lung tissues was tested by quantitative real-time PCR; and IL-1β in plasma was measured by ELISA...
December 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
Heedoo Lee, Duo Zhang, Ziwen Zhu, Charles S Dela Cruz, Yang Jin
Intercellular communications between lung epithelial cells and alveolar macrophages play an essential role in host defense against acute lung injury. Hyperoxia-induced oxidative stress is an established model to mimic human lung injury. We show that after hyperoxia-associated oxidative stress, a large amount of extracellular vesicles (EVs) are detectable in bronchoalveolar lavage fluid (BALF) and culture medium of lung epithelial cells. Microvesicles (MVs), but not exosomes (Exos) or apoptotic bodies (Abs), are the main type of EVs found in the early stages after hyperoxia...
October 12, 2016: Scientific Reports
Maciej Siński, Jacek Lewandowski, Anna Dobosiewicz, Jacek Przybylski, Piotr Abramczyk, Zbigniew Gaciong
INTRODUCTION: Hyperoxia increases total peripheral resistance by acting locally but also inhibits the activity of carotid body chemoreceptors. We studied the effect of hyperoxia on central pressure in normotensive subjects. MATERIAL AND METHODS: Medical air followed by 100% oxygen was provided to 19 subjects (12/7 female/male, age 28.2 ±1.1 years) for 15 min through a non-rebreather mask. Central blood pressure was then measured using applanation tonometry. RESULTS: After the first 2 min of hyperoxia, heart rate decreased significantly (65 ±2...
October 1, 2016: Archives of Medical Science: AMS
Megan R Sutherland, Chanel Béland, Marie-Amélie Lukaszewski, Anik Cloutier, Mariane Bertagnolli, Anne Monique Nuyt
Preterm neonates are prematurely exposed to high oxygen levels at birth which may adversely impact ongoing renal development. The aim of this study was to determine the effects of neonatal hyperoxia exposure on renal function and morphology with aging. Sprague Dawley rat pups were raised in a hyperoxic environment (80% oxygen) from P3 to P10 during ongoing postnatal nephrogenesis. Control litters were kept in room air (n = 6-8 litters/group; one male, one female/litter/age). Kidney function (urine and plasma creatinine, sodium, and protein) and morphology (renal corpuscle size, glomerulosclerosis, fibrosis, and glomerular crescents) were assessed at 1, 5, and 11 months of age...
August 2016: Physiological Reports
Benedikt Nußbaum, Peter Radermacher, Pierre Asfar, Clair Hartmann
Hyperoxia is common practice in the acute management of circulatory shock, and observational studies report that it is present in more than 50 % of mechanically ventilated patients during the first 24 h after intensive care unit (ICU) admission. On the other hand, "oxygen toxicity" due to the increased formation of reactive oxygen species limits its use due to serious deleterious side effects. However, formation of reactive oxygen species to boost bacterial killing is one of the body's anti-microbial auto-defense mechanisms and, hence, O2 has been referred to as an antibiotic...
August 16, 2016: Critical Care: the Official Journal of the Critical Care Forum
Kathleen Cantow, Andreas Pohlmann, Bert Flemming, Fabienne Ferrara, Sonia Waiczies, Dirk Grosenick, Thoralf Niendorf, Erdmann Seeliger
The superparamagnetic iron oxide nanoparticle ferumoxytol is increasingly used as intravascular contrast agent in magnetic resonance imaging (MRI). This study details the impact of ferumoxytol on regulation of renal hemodynamics and oxygenation. In 10 anesthetized rats, a single intravenous injection of isotonic saline (used as volume control) was followed by three consecutive injections of ferumoxytol to achieve cumulative doses of 6, 10, and 41 mg Fe/kg body mass. Arterial blood pressure, renal blood flow, renal cortical and medullary perfusion and oxygen tension were continuously measured...
2016: Scientific Reports
Guven Kaya, Mehmet Saldir, Adem Polat, M Kursat Fidanci, Aysegul Erdem, Galip Erdem, Yasemin Gulcan Kurt, Merih Cetinkaya, Ferhat Cekmez, Onder Onguru, Turan Tunc
BACKGROUND: Many factors contribute to the development of BPD basically by increasing inflammation in preterm lungs. However, premature neonates have insufficient anti-inflammatory capacity. We aimed to evaluate the effect of etanercept, an anti-TNF agent, on BPD development in newborn rat model with hyperoxia-induced lung injury. METHODS: Thirty-two newborn rats were divided into 3 groups as control group (Group 1, n = 11), hyperoxia + placebo group (Group 2, n = 10), and hyperoxia + etanercept group (Group 3, n = 11)...
2016: Fetal and Pediatric Pathology
Zhao-Hua Zhang, Yan-Yan Pan, Rui-Sheng Jing, Yun Luan, Luan Zhang, Chao Sun, Feng Kong, Kai-Lin Li, Yi-Biao Wang
Bronchopulmonary dysplasia (BPD) is the most common type of chronic lung disease in infancy, for which no effective therapy is currently available. The aim of the present study was to investigate the effect of treatment with bone marrow mesenchymal stem cells (BMSCs) in combination with recombinant human erythropoietin (rHuEPO) on BPD‑induced mouse lung injury, and discuss the underlying mechanism. The BPD model was established by the exposure of neonatal mice to continuous high oxygen exposure for 14 days, following which 1x106 BMSCs and 5,000 U/kg rHuEPO were injected into the mice 1 h prior to and 7 days following exposure to hyperoxia...
August 2016: Molecular Medicine Reports
Chung-Ming Chen, Hsiu-Chu Chou
Animal studies have demonstrated that neonatal hyperoxia injures the distal small intestine. This study aimed to determine the effects of neonatal hyperoxia exposure on the intestinal morphology and intestinal barrier integrity in newborn rats. Sprague-Dawley rat pups were exposed to either ambient air or hyperoxia. The ambient air and normobaric hyperoxia groups were maintained in room air and 85% O2 for 2weeks, respectively. The rats were euthanized on Postnatal Day 14, and the terminal ileum was collected for histological analyses and oxidative stress measurements...
August 2016: Experimental and Molecular Pathology
Qian Li, Stephanie B Wall, Changchun Ren, Markus Velten, Cynthia L Hill, Morgan L Locy, Lynette K Rogers, Trent E Tipple
Oxygen toxicity and antioxidant deficiencies contribute to the development of bronchopulmonary dysplasia. Aurothioglucose (ATG) and auranofin potently inhibit thioredoxin reductase-1 (TrxR1), and TrxR1 disruption activates nuclear factor E2-related factor 2 (Nrf2), a regulator of endogenous antioxidant responses. We have shown previously that ATG safely and effectively prevents lung injury in adult murine models, likely via Nrf2-dependent mechanisms. The current studies tested the hypothesis that ATG would attenuate hyperoxia-induced lung developmental deficits in newborn mice...
September 2016: American Journal of Respiratory Cell and Molecular Biology
Fumihiko Namba, Ryo Ogawa, Masato Ito, Takaaki Watanabe, Phyllis A Dennery, Masanori Tamura
AIM: Premature infants are often exposed to hyperoxia to maintain adequate oxygenation, which may lead to the development of bronchopulmonary dysplasia (BPD). Sex-specific differences exist in the development and severity of BPD. Only a few studies have examined the mechanisms underlying these sex-related differences. The aim of the present study is to examine the sex-related long-term effects of neonatal hyperoxia on the lungs of adult mice. MATERIALS AND METHODS: Newborn mice were exposed to 95% oxygen (hyperoxia) for 96 hours and were allowed to recover in room air to adulthood (8 weeks of age)...
2016: Experimental Lung Research
Tyler M Basting, Chikara Abe, Kenneth E Viar, Ruth L Stornetta, Patrice G Guyenet
KEY POINTS: Arterial PCO2 is kept constant via breathing adjustments elicited, at least partly, by central chemoreceptors (CCRs) and the carotid bodies (CBs). The CBs may be active in a normal oxygen environment because their removal reduces breathing. Thereafter, breathing slowly returns to normal. In the present study, we investigated whether an increase in the activity of CCRs accounts for this return. One week after CB excision, the hypoxic ventilatory reflex was greatly reduced as expected, whereas ventilation and blood gases at rest under normoxia were normal...
June 15, 2016: Journal of Physiology
Matthew T Borzage, Adam M Bush, Soyoung Choi, Aart J Nederveen, Lena Václavů, Thomas D Coates, John C Wood
Sickle cell disease (SCD) is the most common cause of stroke in childhood and results primarily from a mismatch of cerebral oxygen supply and demand rather than arterial obstruction. However, resting cerebral blood flow (CBF) has not been examined in the general African American population, in whom obesity, hypertension, cerebrovascular disease, and diminished cerebrovascular reserve capacity are common. To better understand the underlying physiological substrate upon which SCD is superimposed, we measured CBF in 32 young (age 28 ± 10 yr), asymptomatic African American subjects with and without sickle cell trait (n= 14)...
April 15, 2016: Journal of Applied Physiology
Pedro González-Muniesa, Laura Garcia-Gerique, Pablo Quintero, Suyen Arriaza, Amaya Lopez-Pascual, J Alfredo Martinez
Several studies have shown a pathological oxygenation (hypoxia/hyperoxia) on the adipose tissue in obese subjects. Additionally, the excess of body weight is often accompanied by a state of chronic low-degree inflammation. The inflammation phenomenon is a complex biological response mounted by tissues to combat injurious stimuli in order to maintain cell homeostasis. Furthermore, it is believed that the abnormal oxygen partial pressure occurring in adipose tissue is involved in triggering inflammatory processes...
2015: Oxidative Medicine and Cellular Longevity
H-G Moon, Y Cao, J Yang, J H Lee, H S Choi, Y Jin
Despite decades of research, the pathogenesis of acute respiratory distress syndrome (ARDS) remains poorly understood, thus impeding the development of effective treatment. Diffuse alveolar damage (DAD) and lung epithelial cell death are prominent features of ARDS. Lung epithelial cells are the first line of defense after inhaled stimuli, such as in the case of hyperoxia. We hypothesized that lung epithelial cells release 'messenger' or signaling molecules to adjacent or distant macrophages, thereby initiating or propagating inflammatory responses after noxious insult...
December 10, 2015: Cell Death & Disease
Xiaoming Jiang, Yubo Ma, Jinfeng Yu, Haihong Li, Fengjie Xie
Complement anaphylatoxins have been investigated extensively; however, the role of complement anaphylatoxin C4a in hyperoxic lung injury has yet to be investigated. To the best of our knowledge, the present study is the first to demonstrate the role of C4a in hyperoxic lung injury in vitro and in vivo. BALB/c mice were ventilated with 100% oxygen with or without C4a treatment for 36 h. The body weight and the relative lung weight of the mice were determined, along with any morphological changes in the lung...
February 2016: Molecular Medicine Reports
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