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https://www.readbyqxmd.com/read/29777253/translation-inhibition-corrects-aberrant-localization-of-mutant-alanine-glyoxylate-aminotransferase-possible-therapeutic-approach-for-hyperoxaluria
#1
Ruth Belostotsky, Roman Lyakhovetsky, Michael Y Sherman, Fanny Shkedy, Shimrit Tzvi-Behr, Roi Bar, Bernd Hoppe, Björn Reusch, Bodo B Beck, Yaacov Frishberg
Primary hyperoxaluria type 1 is a severe kidney stone disease caused by abnormalities of the peroxisomal alanine-glyoxylate aminotransferase (AGT). The most frequent mutation G170R results in aberrant mitochondrial localization of the active enzyme. To evaluate the population of peroxisome-localized AGT, we developed a quantitative Glow-AGT assay based on the self-assembly split-GFP approach and used it to identify drugs that can correct mislocalization of the mutant protein. In line with previous reports, the Glow-AGT assay showed that mitochondrial transport inhibitors DECA and monensin increased peroxisomal localization of the mutant...
May 18, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29777204/critical-role-of-climate-change-in-plant-selection-and-millet-domestication-in-north-china
#2
Xiaoyan Yang, Wenxiang Wu, Linda Perry, Zhikun Ma, Ofer Bar-Yosef, David J Cohen, Hongbo Zheng, Quansheng Ge
While North China is one of the earliest independent centers for cereal domestication in the world, the earliest stages of the long process of agricultural origins remain unclear. While only millets were eventually domesticated in early sedentary societies there, recent archaeobotanical evidence reported here indicates that grasses from the Paniceae (including millets) and Triticeae tribes were exploited together by foraging groups from the Last Glacial Maximum to the mid-Holocene. Here we explore how and why millets were selected for domestication while Triticeae were abandoned...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29777156/high-quality-3d-photonics-using-nano-imprint-lithography-of-fast-sol-gel-materials
#3
Ofer Bar-On, Philipp Brenner, Tobias Siegle, Raz Gvishi, Heinz Kalt, Uli Lemmer, Jacob Scheuer
A method for the realization of low-loss integrated optical components is proposed and demonstrated. This approach is simple, fast, inexpensive, scalable for mass production, and compatible with both 2D and 3D geometries. The process is based on a novel dual-step soft nano imprint lithography process for producing devices with smooth surfaces, combined with fast sol-gel technology providing highly transparent materials. As a concrete example, this approach is demonstrated on a micro ring resonator made by direct laser writing (DLW) to achieve a quality factor improvement from one hundred thousand to more than 3 million...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29777122/alcohol-facilitates-detection-of-concealed-identity-information
#4
Kristina Suchotzki, Matthias Gamer
The Concealed Information Test (CIT) is a well-validated means to detect whether someone possesses certain (e.g., crime-relevant) information. The current study investigated whether alcohol intoxication during CIT administration influences reaction time (RT) CIT-effects. Two opposing predictions can be made. First, by decreasing attention to critical information, alcohol intoxication could diminish CIT-effects. Second, by hampering the inhibition of truthful responses, alcohol intoxication could increase CIT-effects...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776530/does-a-tow-bar-increase-the-risk-of-neck-injury-in-rear-end-collisions
#5
Anne Vingaard Olesen, Rune Elvik, Camilla Sloth Andersen, Harry S Lahrmann
INTRODUCTION: Does a tow-bar increase the risk of neck injury in the struck car in a rear-end collision? The rear part of a modern car has collision zones that are rendered nonoperational when the car is equipped with a tow-bar. Past crash tests have shown that a car's acceleration was higher in a car equipped with a tow-bar and also that a dummy placed in a car with a tow-bar had higher peak acceleration in the lower neck area. METHOD: This study aimed to investigate the association between the risk of neck injury in drivers and passengers, and the presence of a registered tow-bar on the struck car in a rear-end collision...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29775983/classification-and-microvascular-flap-selection-for-anterior-cranial-fossa-reconstruction
#6
James D Vargo, Wojciech Przylecki, Paul J Camarata, Brian T Andrews
BACKGROUND:  Microvascular reconstruction of the anterior cranial fossa (ACF) creates difficult challenges. Reconstructive goals and flap selection vary based on the defect location within the ACF. This study evaluates the feasibility and reliability of free tissue transfer for salvage reconstruction of low, middle, and high ACF defects. METHODS:  A retrospective review was performed. Reconstructions were anatomically classified as low (anterior skull base), middle (frontal bar/sinus), and high (frontal bone/soft tissue)...
May 18, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29775975/misleading-new-insights-into-the-chrysotile-debate
#7
H-J Woitowitz, X Baur
Although there is no dispute among independent scientists about the carcinogenic and fibrogenic effects of chrysotile, the asbestos industry has been continuously and successfully acting to cast doubts on its harm. Another approach including asbestos insurance entities is to refuse compensation by raising the bar and fight criminal prosecution for asbestos-related diseases by the help of paid scientists. A recent publication on asbestos fibre burden in human lungs fits well in this context. The claim that chrysotile fibres are biopersistent in human lung is not based on the data provided by these authors, and, additionally, exhibits serious inconsistencies and obvious mismeasurements and significant methodological problems...
May 18, 2018: Pneumologie
https://www.readbyqxmd.com/read/29775117/intravenous-low-dose-ketamine-provides-greater-pain-control-compared-to-fentanyl-in-a-civilian-prehospital-trauma-system-a-propensity-matched-analysis
#8
E Stein Bronsky, Catherine Koola, Alessandro Orlando, Diane Redmond, Cecile D'Huyvetter, Heather Sieracki, Allen Tanner, Ray Fowler, Charles Mains, David Bar-Or
OBJECTIVE: A few studies report comparable analgesic efficacy between low-dose ketamine and opioids such as morphine or fentanyl; however, limited research has explored the safety and effectiveness of intravenous low-dose ketamine as a primary analgesic in a civilian prehospital setting. The objective of this study is to compare pain control between low-dose ketamine and fentanyl when administered intravenously (IV) for the indication of severe pain. METHODS: This was a retrospective, observational review of prehospital adult patients (≥18 years) who presented with severe pain (numeric rating scale, 7-10) and were treated solely with either low-dose ketamine IV or fentanyl IV between January 1, 2014 and December 31, 2016...
May 18, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29774662/highly-nitrogen-doped-porous-carbon-derived-from-zeolitic-imidazolate-framework-8-for-co2-capture
#9
Xiancheng Ma, Liqing Li, Ruofei Chen, Chunhao Wang, Haoyang Li, Hailong Li
CO2 adsorption capacity of nitrogen-doped porous carbon depends to a large nitrogen doping levels and high surface area in previous studies. However, it seems difficult to incorporate large amounts of nitrogen while maintaining a high surface area and pore structure. Here we have reported porous carbon having a nitrogen content of up to 25.52% and specific surface area of 948 m2 g-1, which is prepared by pyrolyzing the nitrogen-containing zeolite imidazole framework-8 and urea composite at 650 °C under a nitrogen atmosphere...
May 18, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29774456/examining-differences-in-breath-alcohol-concentration-brac-levels-and-hazardous-drinking-by-smoking-status-among-a-sample-of-college-student-bar-patrons
#10
Ryan J Martin, Molly Robinson, Jennifer Cremeens-Matthews, Beth H Chaney, Kristyn Wynn, Joseph G L Lee
While the association between current smoking and alcohol consumption is well known, the relationship between social smoking and alcohol consumption is less understood. The purpose of this study was to examine the association between smoking status and two alcohol consumption measures in a sample of college student bar patrons. The data used in this study was collected in fall 2015. Study participants (N = 415) were college student bar patrons who agreed to complete an interview that assessed smoking status (i...
May 17, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29774229/web-pages-what-can-you-see-in-a-single-fixation
#11
Ali Jahanian, Shaiyan Keshvari, Ruth Rosenholtz
Research in human vision suggests that in a single fixation, humans can extract a significant amount of information from a natural scene, e.g. the semantic category, spatial layout, and object identities. This ability is useful, for example, for quickly determining location, navigating around obstacles, detecting threats, and guiding eye movements to gather more information. In this paper, we ask a new question: What can we see at a glance at a web page - an artificial yet complex "real world" stimulus? Is it possible to notice the type of website, or where the relevant elements are, with only a glimpse? We find that observers, fixating at the center of a web page shown for only 120 milliseconds, are well above chance at classifying the page into one of ten categories...
2018: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/29773321/evaluating-scenarios-of-locations-and-capacities-for-vaccine-storage-in-nigeria
#12
Dor Hirsh Bar Gai, Zachary Graybill, Paule Voevodsky, Ekundayo Shittu
Many developing countries still face the prevalence of preventable childhood diseases because their vaccine supply chain systems are inadequate by design or structure to meet the needs of their populations. Currently, Nigeria is evaluating options in the redesign of the country's vaccine supply chain. Using Nigeria as a case study, the objective is to evaluate different regional supply chain scenarios to identify the cost minimizing optimal hub locations and storage capacities for doses of different vaccines to achieve a 100% fill rate...
May 14, 2018: Vaccine
https://www.readbyqxmd.com/read/29772501/insights-into-the-effect-of-the-catalytic-functions-on-selective-production-of-ethylene-glycol-from-lignocellulosic-biomass-over-carbon-supported-ruthenium-and-tungsten-catalysts
#13
Lucília Sousa Ribeiro, José J Melo Órfão, Manuel Fernando Ribeiro Pereira
The one-pot conversion of cellulose to ethylene glycol (EG) was investigated using a combination of a ruthenium catalyst supported on carbon nanotubes modified with nitric acid (Ru/CNT1 ) and a tungsten catalyst supported on commercial non-treated carbon nanotubes (W/CNT0 ). This physical mixture allowed to obtain an EG yield of 41% in just 5 h at 205 °C and 50 bar of H2 , which overcame the result obtained using a Ru-W bimetallic catalyst supported on commercial carbon nanotubes (35%) under the same conditions...
May 9, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29772392/effects-of-task-repetition-but-no-transfer-of-inhibitory-control-training-in-healthy-adults
#14
Tobias Talanow, Ulrich Ettinger
Executive functions (EFs) comprise the updating, shifting and inhibition dimensions. According to the Unity and Diversity Model, the inhibition dimension is fully accounted for by a general EFs factor. This suggests that training of inhibition should transfer, in part, to updating and shifting. Therefore, we tested the effectiveness of a three-week inhibition training (high-conflict Stroop task) and explored near transfer effects to an untrained inhibition task (antisaccade task) and far transfer effects to untrained tasks demanding task-set shifting (number-letter-task), working memory updating (n-back task) and planning abilities (Stockings of Cambridge task)...
May 14, 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29771836/palatal-wiring-renewing-an-old-technique-circumpalatal-wiring
#15
Amin Rahpeyma, Saeedeh Khajehahmadi
Circumpalatal wiring has 2 negative points. The first is premature loosening of the wire and the second is tongue irritation caused by exposed wire in roof of the mouth. In this article, a modified technique (palatal wiring) is introduced in which these 2 problems are targeted. In this technique, a small bur hole is created into the hard palate, without the need for flap reflection and wire is passed through it, grasps in the nose, and returns to the oral cavity via sublabial puncture point then 2 ends are twisted in labial vestibule...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29771111/the-chemical-history-of-a-bubble
#16
Kenneth S Suslick, Nathan C Eddingsaas, David J Flannigan, Stephen D Hopkins, Hangxun Xu
Acoustic cavitation (the growth, oscillation, and rapid collapse of bubbles in a liquid) occurs in all liquids irradiated with sufficient intensity of sound or ultrasound. The collapse of such bubbles creates local heating and provides a unique source of energy for driving chemical reactions. In addition to sonochemical bond scission and formation, cavitation also induces light emission in many liquids. This phenomenon of sonoluminescence (SL) has captured the imagination of many researchers since it was first observed 85 years ago...
May 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29770609/whole-exome-sequencing-for-variant-discovery-in-blepharospasm
#17
Jun Tian, Satya R Vemula, Jianfeng Xiao, Enza Maria Valente, Giovanni Defazio, Simona Petrucci, Angelo Fabio Gigante, Monika Rudzińska-Bar, Zbigniew K Wszolek, Kathleen D Kennelly, Ryan J Uitti, Jay A van Gerpen, Peter Hedera, Elizabeth J Trimble, Mark S LeDoux
BACKGROUND: Blepharospasm (BSP) is a type of focal dystonia characterized by involuntary orbicularis oculi spasms that are usually bilateral, synchronous, and symmetrical. Despite strong evidence for genetic contributions to BSP, progress in the field has been constrained by small cohorts, incomplete penetrance, and late age of onset. Although several genetic etiologies for dystonia have been identified through whole-exome sequencing (WES), none of these are characteristically associated with BSP as a singular or predominant manifestation...
May 16, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29770507/flatlands-in-the-holy-land-the-evolution-of-layered-materials-research-in-israel
#18
REVIEW
Oded Hod, Michael Urbakh, Doron Naveh, Maya Bar-Sadan, Ariel Ismach
The experimental identification of fullerenes in 1985, carbon nanotubes in 1991, inorganic nanotubes in 1992, and graphene in 2004 are cornerstone events that have marked the beginning of the layered nanostructures era of materials science. Nowadays, the synthesis of such low-dimensional systems is a routine practice allowing the controlled fabrication of 0-, 1-, and 2D layered structures of diverse chemical compositions. These systems possess unique physical properties that stem from their structural anisotropy characterized by strong intralayer covalent bonding and weaker interlayer dispersive interactions...
May 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29769303/how-alternative-splicing-affects-membrane-trafficking-dynamics
#19
REVIEW
R Eric Blue, Ennessa G Curry, Nichlas M Engels, Eunice Y Lee, Jimena Giudice
The cell biology field has outstanding working knowledge of the fundamentals of membrane-trafficking pathways, which are of critical importance in health and disease. Current challenges include understanding how trafficking pathways are fine-tuned for specialized tissue functions in vivo and during development. In parallel, the ENCODE project and numerous genetic studies have revealed that alternative splicing regulates gene expression in tissues and throughout development at a post-transcriptional level. This Review summarizes recent discoveries demonstrating that alternative splicing affects tissue specialization and membrane-trafficking proteins during development, and examines how this regulation is altered in human disease...
May 16, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29768570/removal-of-synthetic-sex-hormones-by-hydrothermal-carbonization
#20
Ruiter L Morais, Mariângela F Santiago, Joachim W Zang, Warde A Fonseca-Zang, Fernando Schimidt
One of the most prominent fields of environmental chemistry is the study and the removal of micro-pollutants from aqueous matrices. Analytical techniques for their identification and quantification are becoming more sensitive and comprehensive and, as a result, an increasing number of drugs have been detected in environmental samples. However, the literature shows that conventional treatments for drinking water and wastewater are not sufficient for remove these compounds. This study aims to check whether the process of hydrothermal carbonization (CHT) is effective in removing the synthetic sex hormones: ethinyl estradiol, gestodene and cyproterone acetate from aqueous samples...
May 14, 2018: Anais da Academia Brasileira de Ciências
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