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https://www.readbyqxmd.com/read/29352617/high-frequency-of-c9orf72-hexanucleotide-repeat-expansion-in-amyotrophic-lateral-sclerosis-patients-from-two-founder-populations-sharing-the-same-risk-haplotype
#1
Orly Goldstein, Mali Gana-Weisz, Beatrice Nefussy, Batel Vainer, Omri Nayshool, Anat Bar-Shira, Bryan J Traynor, Vivian E Drory, Avi Orr-Urtreger
We characterized the C9orf72 hexanucleotide repeat expansion (RE) mutation in amyotrophic lateral sclerosis (ALS) patients of 2 distinct origins, Ashkenazi and North Africa Jews (AJ, NAJ), its frequency, and genotype-phenotype correlations. In AJ, 80% of familial ALS (fALS) and 11% of sporadic ALS carried the RE, a total of 12.9% of all AJ-ALS compared to 0.3% in AJ controls (odds ratio [OR] = 44.3, p < 0.0001). In NAJ, 10% of fALS and 9% of sporadic ALS carried the RE, a total of 9.1% of all NAJ-ALS compared to 1% in controls (OR = 9...
December 27, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29351858/determination-of-semicarbazide-in-fish-by-molecularly-imprinted-stir-bar-sorptive-extraction-coupled-with-high-performance-liquid-chromatography
#2
Tang Tang, Fangdi Wei, Xu Wang, Yujie Ma, Yueyue Song, Yunsu Ma, Quan Song, Guanhong Xu, Yao Cen, Qin Hu
A novel molecularly imprinted stir bar (MI-SB) for sorptive extraction of semicarbazide (SEM) was prepared in present paper. The coating of the stir bar was characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, dynamic adsorption and static adsorption tests. The saturated adsorption of MI-SB was about 4 times over that of non-imprinted stir bar (NI-SB). The selectivity of MI-SB for SEM was much better than NI-SB. A method to determine SEM was established by coupling MI-SB sorptive extraction with HPLC-UV...
January 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29351178/using-time-referenced-data-to-assess-medication-administration-performance-and-quality
#3
John M Welton, Catherine Kleiner, Carolyn Valdez, Sara Richardson, Kathy Boyle, Eric Lucas
OBJECTIVE: This study tests the feasibility of using a large (big) clinical data set to test the ability to extract time-referenced data related to medication administration to identify late doses and as-needed (PRN) administration patterns by RNs in an inpatient setting. METHODS: The study is a secondary analysis of a set of data using bar-code medication administration time stamps (n = 3043812) for 50883 patients admitted to a single, urban, 525-bed hospital in 11 inpatient units by 714 nurses between April 1, 2013, and March 31, 2015...
February 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29350715/simulation-of-ktp-laser-based-zenker-diverticulotomy-with-a-porcine-model-and-laryngeal-dissection-station
#4
Matthew R Hoffman, Heidi Kletzien, Seth H Dailey, J Scott McMurray
Zenker's diverticulum is a rare cause of progressive dysphagia that is treated surgically. KTP laser-based diverticulotomy is one effective treatment. Developing a simulation model is helpful for rare conditions. Pigs have a natural hypopharyngeal pouch similar to a diverticulum. We present a model for performing rigid endoscopic KTP laser diverticulotomy in a porcine model using a laryngeal dissection station. Eleven pigs were examined to confirm presence of the hypopharyngeal pouch. A specimen was mounted on the modified laryngeal dissection station and a KTP laser-based diverticulotomy was performed...
December 2017: OTO Open
https://www.readbyqxmd.com/read/29348611/prediction-is-production-the-missing-link-between-language-production-and-comprehension
#5
Clara D Martin, Francesca M Branzi, Moshe Bar
Language comprehension often involves the generation of predictions. It has been hypothesized that such prediction-for-comprehension entails actual language production. Recent studies provided evidence that the production system is recruited during language comprehension, but the link between production and prediction during comprehension remains hypothetical. Here, we tested this hypothesis by comparing prediction during sentence comprehension (primary task) in participants having the production system either available or not (non-verbal versus verbal secondary task)...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348208/learning-to-make-external-sensory-stimulus-predictions-using-internal-correlations-in-populations-of-neurons
#6
Audrey J Sederberg, Jason N MacLean, Stephanie E Palmer
To compensate for sensory processing delays, the visual system must make predictions to ensure timely and appropriate behaviors. Recent work has found predictive information about the stimulus in neural populations early in vision processing, starting in the retina. However, to utilize this information, cells downstream must be able to read out the predictive information from the spiking activity of retinal ganglion cells. Here we investigate whether a downstream cell could learn efficient encoding of predictive information in its inputs from the correlations in the inputs themselves, in the absence of other instructive signals...
January 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29347866/effects-of-cereal-bar-containing-polydextrose-on-subjective-feelings-of-appetite-and-energy-intake-in-overweight-adults-over-15-d
#7
Marcela Martinelli, Emilia Hick, Florencia Walz, Silvina R Drago
The effects of 15 d polydextrose (16.7 g) consumption on energy intake (EI) and appetite feelings were investigated. Overweight adults consumed a polydextrose-bar or a control-bar matched in energy content as a midmorning snack for 15 consecutive days in a single-blind, randomised, crossover design. The two 15-d intervention periods were separated by a 15-d washout period. On the day 1 and the day 15 of each intervention period, energy intake (primary outcome) and appetite feelings (secondary outcome) were assessed...
January 18, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29347008/erratum-correlations-in-suspensions-confined-between-viscoelastic-surfaces-noncontact-microrheology-phys-rev-e-96-022607-2017
#8
Chen Bar-Haim, Haim Diamant
This corrects the article DOI: 10.1103/PhysRevE.96.022607.
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345998/key-factors-inhibiting-legislative-progress-toward-smoke-free-coverage-in-appalachia
#9
J Travis Donahoe, Andrea R Titus, Nancy L Fleischer
The Appalachian Region has among the highest rates of smoking and smoking-related illness in the United States. Strong smoke-free legislation could help protect nonsmoking residents from the harmful effects of secondhand smoke. However, there is a dearth of state, county, city, and subcounty smoke-free law coverage throughout Appalachia. As of July 2016, only 21% of Appalachian residents were covered by comprehensive smoke-free laws (i.e., 100% coverage for workplaces, restaurants, and bars). Only 46% of Appalachians lived in places with 100% smoke-free workplace laws, only 30% lived in places with 100% smoke-free restaurant laws, and only 29% lived in places with 100% smoke-free bar laws...
January 18, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29345502/extended-3d-and-4d-cumulative-plots-for-evaluation-of-unmatched-incurred-sample-reanalysis
#10
Piotr J Rudzki, Michał Kaza, Przemysław Biecek
AIM: Incurred sample reanalysis (ISR) helps ensure the reliability of pharmacokinetic studies. An appropriate graph may facilitate the evaluation of an unmatched reanalyses or a failed ISR test. METHODS: We evaluated different ways of visualizing multidimensional ISR data using an extended cumulative ISR plot. RESULTS: 3D and 4D cumulative ISR plots enable comprehensive data analysis using a single plot. We propose to use color for percentage difference classes in bar and XY-scatter plots...
January 18, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29344909/flash-induced-forward-and-reverse-illusory-line-motion-in-offset-bars
#11
Sihang Han, Jeff P Hamm
Illusory line motion (ILM) refers to perception of motion in a bar that onsets or offsets all at once. When the bar onsets or offsets between two boxes after one of the boxes flashes, the bar appears to shoot out of the flashed box (flashILM). If the bar offsets during the flash, it appears to contract into the flashed box (reverse ILM; rILM). Onset bars do not show rILM. Moreover, rILM and flashILM are not correlated, indicating they are two different illusions. To date, rILM has only been studied using a 50-ms flash where the bar offsets 16...
January 17, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29344534/the-effect-of-self-care-education-on-emotional-intelligence-and-hba1c-level-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-clinical-trial
#12
Salma Tavakol Moghadam, Seyed Saeed Najafi, Shahrzad Yektatalab
Background: The role of Emotional Intelligence (EI) in glycemic control in type 2 Diabetes Mellitus (DM) has not been fully understood. The present study aimed to investigate the effect of self-care education on EI and hemoglobin glycosylated (HbA1c) in patients with type 2 diabetes. Methods: In this randomized controlled clinical trial, 48 patients with type 2 DM referred to Shahid Motahari Diabetes Center in 2015 were divided into an intervention and a control group using block randomization...
January 2018: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29343550/cdk1-dependent-phospho-inhibition-of-a-formin-f-bar-interaction-opposes-cytokinetic-contractile-ring-formation
#13
Alaina H Willet, K Adam Bohnert, Kathleen L Gould
In Schizosaccharomyces pombe, cytokinesis requires the assembly and constriction of an actomyosin-based contractile ring (CR). A single essential formin, Cdc12, localizes to the cell middle upon mitotic onset and nucleates the F-actin of the CR. Cdc12 medial recruitment is mediated in part by its direct binding to the F-BAR scaffold Cdc15. Given that Cdc12 is hyper-phosphorylated in M phase, we explored whether Cdc12 phospho-regulation impacts its association with Cdc15 during mitosis. We found that Cdk1, a major mitotic kinase, phosphorylates Cdc12 on six N-terminal residues near the Cdc15-binding site...
January 17, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29342421/the-relation-between-plasma-%C3%AE-synuclein-level-and-clinical-symptoms-or-signs-of-parkinson-s-disease
#14
Michalina Malec-Litwinowicz, Andrzej Plewka, Danuta Plewka, Edyta Bogunia, Michał Morek, Andrzej Szczudlik, Michał Szubiga, Monika Rudzińska-Bar
INTRODUCTION: Parkinson disease (PD) is the common neurodegenerative disease. α-Synuclein (ASN), main aggregating protein in neural cells of CNS in PD, was found in peripheral fluids. Testing ASN in plasma is potential test for diagnose PD, but previous studies are controversial. The aim of this study was to investigate if plasma ASN level may be a valuable biomarker, is the level of plasma ASN concentration different in various motor subtypes of diseases, is there a relation between the level of plasma ASN and the severity of motor symptoms...
November 21, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29341920/effect-of-structural-factors-on-release-profiles-of-camptothecin-from-block-copolymer-conjugates-with-high-load-of-drug
#15
Andrzej Plichta, Sebastian Kowalczyk, Ewa Olędzka, Marcin Sobczak, Marcin Strawski
The aim of the present work was the synthesis and study the kinetics and profiles of camptothecin (CPT) release form block co- and ter-polymer conjugates comprising polylactide (PLA) segments and CPT moieties, structurally diverse by degrees of branching, content of D-PLA units and poly(ethylene glycol) methyl ether methacrylate (PEGMA). Six PLA, non-toxic macroinitiators (MIs), terminated with α-bromoester were synthesized. MIs were subjected to polymerization of CPT methacrylic derivative (CPTMA) with PEGMA at various ratios...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29341786/unscheduled-adolescents-return-to-the-emergency-department-following-acute-concussion
#16
Dana Baron Shahaf, Sapir Bar, Ronit Leiba, Vered Dvir, Itai Shavit
OBJECTIVE: Emergency department (ED) visits due to concussion have increased over recent years. We aimed to identify variables associated with unscheduled adolescents return to the ED. METHODS: A retrospective cohort study was conducted. All children aged 11 to 18 years who were admitted to the ED due to concussion between 2011 and 2016 were included. Multivariable logistic regression was performed to identify predictors of ED return. RESULTS: Overall, 616 adolescents were admitted to the ED due to concussion...
January 17, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29341468/downregulation-of-barh-like-homeobox-2-promotes-cell-proliferation-migration-and-aerobic-glycolysis-through-wnt-%C3%AE-catenin-signaling-and-predicts-a-poor-prognosis-in-non-small-cell-lung-carcinoma
#17
Hao Chen, Maowei Zhang, Wenhui Zhang, Yuanqin Li, Jiechen Zhu, Xiaojiao Zhang, Li Zhao, Shuyang Zhu, Bi Chen
BACKGROUND: Human BarH-like homeobox 2 (Barx2), a homeodomain factor of the Bar family, plays a critical role in cell adhesion and cytoskeleton remodeling, and has been reported in an increasing array of tumor types except non-small cell lung carcinoma (NSCLC). The purpose of the current study was to characterize the expression of Barx2 and assess the clinical significance of Barx2 in NSCLC. METHODS: Quantitative real-time polymerase chain reaction, immunohistochemistry and western blot analysis were used to examine mRNA and protein expression, respectively...
January 17, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29340788/the-impact-of-advanced-maternal-age-on-the-outcome-of-twin-pregnancies
#18
Ohad Gluck, Yossi Mizrachi, Jacob Bar, Giulia Barda
PURPOSE: To assess the effect of advanced maternal age on the obstetrics and neonatal outcome of twin pregnancies. METHODS: A retrospective study of 716 dichorionic-diamniotic twin pregnancies delivered at our institute. The study population was divided into two groups: women aged 35-39 years (group A, n = 142) and women aged ≥ 40 years (Group B, n = 48). The control group consisted of women younger than 35 years (group C, n = 516). RESULTS: The rate of cesarean section (CS) was significantly higher among women older than 35 years compared to the control group (A 76...
January 16, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29339299/is-there-a-difference-in-the-outcome-of-mid-urethral-sling-operations-performed-by-urogynecologists-as-compared-to-supervised-residents
#19
Osnat Elyashiv, Noa Mevorach Zussman, Masha Ben-Zvi, Jacob Bar, Ron Sagiv, Alexander Condrea, Shimon Ginath
STUDY OBJECTIVE: To compare the operative results of midurethral sling (MUS) surgeries for stress urinary incontinence (SUI) performed by residents under the guidance of an attending specialist in urogynecology, to those done by attendings. DESIGN: Retrospective chart review DESIGN CLASSIFICATION: Canadian Task Force classification II-2 SETTING: University hospital PATIENTS: A retrospective analysis of all MUS's performed between January 2009 to December 2013, in a single public tertiary medical center, was carried out...
January 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29338756/spatial-access-to-restaurants-and-grocery-stores-in-relation-to-frequency-of-home-cooking
#20
Maria Gabriela M Pinho, Joreintje D Mackenbach, Hélène Charreire, Jean-Michel Oppert, Helga Bárdos, Harry Rutter, Sofie Compernolle, Joline W J Beulens, Johannes Brug, Jeroen Lakerveld
BACKGROUND: Little is known about the relation between the neighbourhood food environment and home cooking. We explored the independent and combined associations between residential neighbourhood spatial access to restaurants and grocery stores with home cooking in European adults. METHODS: Data of 5076 participants of the SPOTLIGHT study were collected across five European countries in 2014. Food retailers were classified into grocery stores (supermarkets and local food shops) and restaurants (full-service restaurants, fast food and take-away restaurants, café/bars)...
January 16, 2018: International Journal of Behavioral Nutrition and Physical Activity
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