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https://www.readbyqxmd.com/read/27872404/unique-cellular-lineage-composition-of-the-first-gland-of-the-mouse-gastric-corpus
#1
Andrew O'Neil, Christine P Petersen, Eunyoung Choi, Amy C Engevik, James R Goldenring
The glandular stomach has two major zones: the acid secreting corpus and the gastrin cell-containing antrum. Nevertheless, a single gland lies at the transition between the forestomach and corpus in the mouse stomach. We have sought to define the lineages that make up this gland unit at the squamocolumnar junction. The first gland in mice showed a notable absence of characteristic corpus lineages, including parietal cells and chief cells. In contrast, the gland showed strong staining of Griffonia simplicifolia-II (GSII)-lectin-positive mucous cells at the bases of glands, which were also positive for CD44 variant 9 and Clusterin...
November 21, 2016: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/27825279/the-normal-squamocolumnar-junction-is-circumferentially-even-and-minimal-irregularities-are-manifestations-of-gastroesophageal-acid-reflux
#2
Mats Guerrero Garcia Hall, Jörgen Wenner, Stefan Öberg
BACKGROUND: The macroscopic appearance of the normal squamocolumnar junction (SCJ) is often described as serrated with short projections of columnar mucosa that extend into the esophagus. As studies of the normal SCJ are sparse, the aim of this study was to test the hypothesis that the normal SCJ is even and that irregularities are manifestations of acid reflux. METHOD: Fifty asymptomatic subjects and 149 patients with symptoms suggestive of gastroesophageal reflux disease underwent endoscopy and 48-h pH monitoring with a pH electrode positioned immediately above the SCJ...
November 8, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27680604/ck7-immunohistochemistry-as-a-predictor-of-cin1-progression-a-retrospective-study-of-patients-from-the-quadrivalent-hpv-vaccine-trials
#3
Anne M Mills, Cherie Paquette, Tatjana Terzic, Philip E Castle, Mark H Stoler
Cervical high-grade squamous intraepithelial lesion (CIN2-3) is thought to arise from a distinct population of cells at the squamocolumnar junction (SCJ). Immunohistochemical (IHC) biomarkers that characterize the SCJ phenotype, including CK7, have been proposed as tools to separate the subset of low-grade squamous intraepithelial lesions (LSILs) (CIN1) that will progress to high-grade squamous intraepithelial lesion from the majority of cases, which will resolve without further intervention. We conducted a retrospective study of CK7 IHC on adjudicated CIN1 tissue from women in the placebo arm of the quadrivalent human papillomavirus (HPV) vaccine trials...
September 27, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27663505/the-gastric-acid-pocket-is-attenuated-in-h-pylori-infected-subjects
#4
David R Mitchell, Mohammad H Derakhshan, Angela A Wirz, Clare Orange, Stuart A Ballantyne, James J Going, Kenneth E L McColl
OBJECTIVE: Gastric acid secretory capacity in different anatomical regions, including the postprandial acid pocket, was assessed in Helicobacter pylori positive and negative volunteers in a Western population. DESIGN: We studied 31 H. pylori positive and 28 H. pylori negative volunteers, matched for age, gender and body mass index. Jumbo biopsies were taken at 11 predetermined locations from the gastro-oesophageal junction and stomach. Combined high-resolution pH metry (12 sensors) and manometry (36 sensors) was performed for 20 min fasted and 90 min postprandially...
September 23, 2016: Gut
https://www.readbyqxmd.com/read/27639133/interpretation-of-colposcopy-in-population-based-cervical-screening-services-in-north-eastern-italy-an-online-interregional-agreement-study
#5
Paola Garutti, Paolo Cristiani, Gian P Fantin, Francesco Sopracordevole, Silvano Costa, Patrizia Schincaglia, Alessandra Ravaioli, Priscilla Sassoli de Bianchi, Carlo Naldoni, Stefano Ferretti, Lauro Bucchi
OBJECTIVE: An innovative web-based colposcopy quality assurance programme was implemented in population-based cervical screening services in three north-eastern Italian administrative regions with different colposcopists' training background. In this study, the levels of intra- and interregional intercolposcopist diagnostic agreement were evaluated. STUDY DESIGN: Of the 158 registered colposcopists, 125 accessed the website of the programme, logged-in, viewed a posted set of 50 digital colpophotographs selected by an expert steering committee, and classified them for the colposcopic impression, the visibility of the squamocolumnar junction, and the need for biopsy...
August 31, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27573773/transcommitment-paving-the-way-to-barrett-s-metaplasia
#6
David H Wang, Rhonda F Souza
Barrett's esophagus is the condition in which metaplastic columnar epithelium that predisposes to cancer development replaces stratified squamous epithelium in the distal esophagus. Potential sources for the cell or tissue of origin for metaplastic Barrett's epithelium are reviewed including native esophageal differentiated squamous cells, progenitor cells native to the esophagus located within the squamous epithelium or in the submucosal glands or ducts, circulating bone marrow-derived stem cells, and columnar progenitor cells from the squamocolumnar junction or the gastric cardia that proximally shift into the esophagus to fill voids left by damaged squamous epithelium...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27564523/colposcopy-and-additive-diagnostic-value-of-biopsies-from-colposcopy-negative-areas-to-detect-cervical-dysplasia
#7
Ingrid Baasland, Bjørn Hagen, Christina Vogt, Marit Valla, Pål R Romundstad
INTRODUCTION: We evaluated colposcopy in the routine diagnostic workup of women with abnormal cervical cytology, as well as the diagnostic value of endocervical curettage material and biopsies taken from colposcopy-positive and colposcopy-negative quadrants of the cervix. MATERIAL AND METHODS: This cross-sectional study included 297 nonpregnant women with abnormal cervical cytology and no prior treatment for cervical dysplasia or cancer. All women underwent gynecological examination, colposcopy, endocervical curettage, and had cervical biopsies taken...
November 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27506510/small-lesion-size-measured-by-colposcopy-may-predict-absence-of-cervical-intraepithelial-neoplasia-in-a-large-loop-excision-of-the-transformation-zone-specimen
#8
M Munmany, L Marimon, M Cardona, R Nonell, M Juiz, R Astudillo, J Ordi, A Torné, M Del Pino
OBJECTIVE: To evaluate whether colposcopic measurement of the lesion size at diagnosis and/or human papillomavirus (HPV) genotyping can predict the absence of dysplasia in a large loop excision of the transformation zone (LLETZ) specimen in women treated for squamous intraepithelial lesions/cervical intraepithelial neoplasia (SIL/CIN). DESIGN: Prospective observational study. SETTING: Tertiary university hospital. POPULATION: A cohort of 116 women who underwent LLETZ because of biopsy-proven low-grade SIL/CIN that had persisted for 2 years, or because of a high-grade SIL/CIN diagnosed in the referral visit and squamocolumnar junction completely visible (types 1 or 2, according to the International Federation of Cervical Pathology and Colposcopy, IFCPC)...
August 9, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27495970/esophageal-mucosal-impedance-pattern-is-distinct-in-patients-with-extraesophageal-reflux-symptoms-and-pathologic-acid-reflux
#9
Robert T Kavitt, Pooja Lal, Elif Saritas Yuksel, Fehmi Ates, James C Slaughter, C Gaelyn Garrett, Tina Higginbotham, Michael F Vaezi
OBJECTIVES/STUDY DESIGN: Current diagnostic tests for gastroesophageal reflux disease (GERD) do not consistently measure chronicity of reflux. Mucosal impedance (MI) is a minimally invasive measurement to assess esophageal conductivity changes due to GERD. We aimed to investigate MI pattern in patients with symptoms of extraesophageal reflux (EER) in a prospective longitudinal cohort study. METHODS: Patients with potential symptoms of EER undergoing esophagogastroduodenoscopy (EGD) with wireless pH monitoring were studied...
August 2, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27446834/cloxacillin-a-new-cause-of-pill-induced-esophagitis
#10
Petros Zezos, Ziv Harel, Fred Saibil
A large variety of medications can cause pill-induced esophagitis. Herein we present a case of cloxacillin-induced esophagitis. A 66-year-old male presented with an acute onset of epigastric and retrosternal pain on the 5th day of a course of oral cloxacillin prescribed for erysipelas. Initial clinical and imaging assessment was negative and he was sent home. A few days later, he returned with persistent severe retrosternal pain; endoscopy at the same day revealed a normal upper esophagus, several small stellate erosions in the midesophagus, and a normal squamocolumnar junction with a small hiatus hernia...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27196581/hiatus-hernia-in-healthy-volunteers-is-associated-with-intrasphincteric-reflux-and-cardiac-mucosal-lengthening-without-traditional-reflux
#11
Elaine V Robertson, Mohammad H Derakhshan, Angela A Wirz, David R Mitchell, James J Going, Andrew W Kelman, Stuart A Ballantyne, Kenneth E L McColl
BACKGROUND AND AIMS: Hiatus hernia (HH) is a key mediator of gastro-oesophageal reflux disease but little is known about its significance in the general population. We studied the structure and function of the gastro-oesophageal junction in healthy volunteers with and without HH. METHODS: We compared 15 volunteers with HH, detected by endoscopy or MRI scan, but without gastro-oesophageal reflux disease with 15 controls matched for age, gender and body weight. Jumbo biopsies were taken across the squamocolumnar junction (SCJ)...
April 25, 2016: Gut
https://www.readbyqxmd.com/read/27004249/hill-classification-is-superior-to-the-axial-length-of-a-hiatal-hernia-for-assessment-of-the-mechanical-anti-reflux-barrier-at-the-gastroesophageal-junction
#12
Ida Hansdotter, Ove Björ, Anna Andreasson, Lars Agreus, Per Hellström, Anna Forsberg, Nicholas J Talley, Michael Vieth, Bengt Wallner
BACKGROUND AND STUDY AIMS: The pathogenesis of gastroesophageal reflux disease (GERD) is multifactorial, including the mechanical anti-reflux barrier of the gastroesophageal junction. This barrier can be evaluated endoscopically in two ways: by measuring the axial length of any hiatal hernia present or by assessing the gastroesophageal flap valve. The endoscopic measurement of axial length is troublesome because of the physiological dynamics in the area. Grading the gastroesophageal flap valve is easier and has proven reproducible...
March 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/26988248/cervical-cancer-stem-cells-selectively-overexpress-hpv-oncoprotein-e6-that-controls-stemness-and-self-renewal-through-upregulation-of-hes1
#13
Abhishek Tyagi, Kanchan Vishnoi, Sutapa Mahata, Gaurav Verma, Yogesh Srivastava, Shashank Masaldan, Bal Gangadhar Roy, Alok C Bharti, Bhudev C Das
PURPOSE: Perturbation of keratinocyte differentiation by E6/E7 oncoproteins of high-risk human papillomaviruses that drive oncogenic transformation of cells in squamocolumnar junction of the uterine cervix may confer "stem-cell like" characteristics. However, the crosstalk between E6/E7 and stem cell signaling during cervical carcinogenesis is not well understood. We therefore examined the role of viral oncoproteins in stem cell signaling and maintenance of stemness in cervical cancer...
August 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26927889/histologic-features-associated-with-columnar-lined-esophagus-in-distal-esophageal-and-gastroesophageal-junction-gej-biopsies-from-gerd-patients-a-community-based-population-study
#14
Genevieve Soucy, Lynn Onstad, Thomas L Vaughan, Robert D Odze
There are inherent problems with the endoscopic and pathologic criteria for columnar-lined esophagus (CLE). Furthermore, the clinical and biological significance of an irregular squamocolumnar junction (SCJ) is unclear. The aim of this study was to evaluate the association between histologic features in SCJ biopsies and CLE and to gain insight into the significance of an irregular SCJ. The study was a cross-sectional analysis of 2176 mucosal biopsies of the SCJ from 544 patients in a large prospective community clinic-based study of gastroesophageal reflux disease in Washington State...
June 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26559525/profiling-of-discrete-gynecological-cancers-reveals-novel-transcriptional-modules-and-common-features-shared-by-other-cancer-types-and-embryonic-stem-cells
#15
Kalliopi I Pappa, Alexander Polyzos, Jasmine Jacob-Hirsch, Ninette Amariglio, George D Vlachos, Dimitrios Loutradis, Nicholas P Anagnou
Studies on individual types of gynecological cancers (GCs), utilizing novel expression technologies, have revealed specific pathogenetic patterns and gene markers for cervical (CC), endometrial (EC) and vulvar cancer (VC). Although the clinical phenotypes of the three types of gynecological cancers are discrete, the fact they originate from a common embryological origin, has led to the hypothesis that they might share common features reflecting regression to early embryogenesis. To address this question, we performed a comprehensive comparative analysis of their profiles...
2015: PloS One
https://www.readbyqxmd.com/read/26551618/predictive-value-of-cytokeratin-7-immunohistochemistry-in-cervical-low-grade-squamous-intraepithelial-lesion-as-a-marker-for-risk-of-progression-to-a-high-grade-lesion
#16
COMPARATIVE STUDY
Cherie Paquette, Anne M Mills, Mark H Stoler
The squamocolumnar junction (SCJ) cell population of the uterine cervix is a discrete epithelial area and the putative source of the majority of high-grade squamous intraepithelial lesions (HSIL). The SCJ cells can be identified by immunohistochemical (IHC) stains including cytokeratin 7 (CK7). Others have theorized that an SCJ marker-positive low-grade squamous intraepithelial lesion (LSIL) has a higher risk for future HSIL compared with an SCJ marker-negative LSIL. This study has 2 aims: first, to refine the definition of a positive CK7 immunostaining pattern in cervical lesions, and, second, to test the hypothesis that CK7 positivity in LSIL indicates higher risk for future HSIL, with both questions addressed using a data set with consensus diagnoses...
February 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26535479/the-role-of-the-acid-pocket-in-gastroesophageal-reflux-disease
#17
David R Mitchell, Mohammad H Derakhshan, Elaine V Robertson, Kenneth E L McColl
Gastroesophageal reflux disease is one of the commonest chronic conditions in the western world and its prevalence is increasing worldwide. The discovery of the acid pocket explained the paradox of acid reflux occurring more frequently in the postprandial period despite intragastric acidity being low due to the buffering effect of the meal. The acid pocket was first described in 2001 when it was detected as an area of low pH immediately distal to the cardia using dual pH electrode pull-through studies 15 minutes after a meal...
February 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/26458862/correlation-of-narrow-band-imaging-endoscopy-and-histopathology-in-the-diagnosis-of-nonerosive-reflux-disease
#18
P Arul, B Vinoth, Thomas Alexander, Manjiri Phansalkar, Somanath Padhi
UNLABELLED: Background /Aim: Narrow band imaging (NBI) is a novel, innovative high-resolution endoscopic technique, which utilizes spectral narrow band filter for the visualization of mucosal patterns and microvasculature. Nonerosive reflux disease (NERD) is a type of gastroesophageal reflux disease (GERD) and it is characterized by reflux symptoms without mucosal breaks on white light endoscopy (WLE). Biopsies from distal esophagus of GERD patients show group of histologic features such as basal cell hyperplasia, elongation of lamina propria papillae, and inflammatory cells...
September 2015: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/26444647/identifying-minimal-changes-in-nonerosive-reflux-disease-is-the-pay-worth-the-labor
#19
REVIEW
Scott L Gabbard, Ronnie Fass, Carla Maradey-Romero, Rachel Gingold Belfer, Ram Dickman
Gastroesophageal reflux disease has a variable presentation on upper endoscopy. Gastroesophageal reflux disease can be divided into 3 endoscopic categories: Barrett's esophagus, erosive esophagitis, and normal mucosa/nonerosive reflux disease (NERD). Each of these phenotypes behave in a distinct manner, in regards to symptom response to treatment, and risk of development of complications such as esophageal adenocarcinoma. Recently, it has been proposed to further differentiate NERD into 2 categories: those with and those without "minimal changes...
January 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/26421104/high-resolution-anoscopy-unchartered-territory-for-gastroenterologists
#20
Andreia Albuquerque
High-resolution anoscopy (HRA) is a procedure where patients with an increased risk of anal cancer, like men who have sex with men, human immunodeficiency virus infected individuals, transplant patients and women with a history of lower genital tract neoplasia, with abnormal anal cytology results, are submitted to anal and perianal visualization under magnification. This will allow for a better detection of anal high-grade lesions that can be treated, in an effort to prevent anal cancer. Anal cancer screening follows the same principles that cervical cancer screening...
September 25, 2015: World Journal of Gastrointestinal Endoscopy
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