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https://www.readbyqxmd.com/read/29093623/presence-of-columnar-lined-esophagus-is-negatively-associated-with-the-presence-of-esophageal-varices-in-japanese-alcoholic-men
#1
Akira Yokoyama, Kenro Hirata, Rieko Nakamura, Tai Omori, Takeshi Mizukami, Junko Aida, Katsuya Maruyama, Tetsuji Yokoyama
AIM: To determine whether the presence of columnar-lined esophagus (CLE) is associated with the presence of esophageal varices (EVs) in male Japanese alcoholics. METHODS: The subjects were 1614 Japanese alcohol-dependent men (≥ 40 years of age) who had undergone upper gastrointestinal endoscopic screening. Digitalized records of high-quality endoscopic images that included the squamocolumnar junction and esophagogastric junction were retrospectively jointly reviewed by four expert endoscopists for the purpose of diagnosing CLE...
October 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28953110/asccp-colposcopy-standards-role-of-colposcopy-benefits-potential-harms-and-terminology-for-colposcopic-practice
#2
Michelle J Khan, Claudia L Werner, Teresa M Darragh, Richard S Guido, Cara Mathews, Anna-Barbara Moscicki, Martha M Mitchell, Mark Schiffman, Nicolas Wentzensen, L Stewart Massad, E J Mayeaux, Alan G Waxman, Christine Conageski, Mark H Einstein, Warner K Huh
OBJECTIVES: The American Society for Colposcopy and Cervical Pathology Colposcopy Standards address the role of and approach to colposcopy and biopsy for cervical cancer prevention in the United States. Working Group 1 was tasked with defining the role of colposcopy, describing benefits and potential harms, and developing an official terminology. METHODS: A systematic literature review was performed. A national survey of American Society for Colposcopy and Cervical Pathology members provided input on current terminology use...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28859392/long-term-wireless-ph-monitoring-of-the-distal-esophagus-prolonging-the-test-beyond-48-hours-is-unnecessary-and-may-be-misleading
#3
G Capovilla, R Salvador, L Spadotto, G Voltarel, E Pesenti, A Perazzolo, L Nicoletti, S Merigliano, M Costantini
Wireless pH monitoring of the esophagus has been widely used to detect GERD for more than a decade. It is generally well tolerated and accepted by patients, but it is still unclear whether prolonging a recording beyond the usual 48 hours can improve the test's diagnostic value. The aim of this study is to examine the diagnostic yield of 96-hour pH monitoring vis-à-vis 24- and 48-hour tests, and to ascertain whether any gain in diagnostic terms was of genuine clinical utility. Patients with suspected GERD underwent 4-day PPI-off wireless pH monitoring of the distal esophagus...
October 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28857936/brief-report-radiofrequency-ablation-therapy-for-anal-intraepithelial-neoplasia-results-from-a-single-center-prospective-pilot-study-in-hiv-participants
#4
Robert N Goldstone, Shirin R Hasan, Stephen E Goldstone
BACKGROUND: HIV-positive individuals have high incidence of anal high-grade squamous intraepithelial lesions (HSIL) at the squamocolumnar junction (SCJ), which can progress to cancer. Focal radiofrequency ablation (RFA) treats HSIL, but metachronous recurrence remains high and may be improved with circumferential treatment. SETTING: The study was performed at a single center. METHODS: This was a prospective trial of circumferential anal RFA using Barrx 60 RFA focal catheters in participants with ≥1 anal SCJ HSIL...
December 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28720443/squamous-intraepithelial-lesions-of-the-anal-squamocolumnar-junction-histopathological-classification-and-hpv-genotyping
#5
Omar Clavero, Jenny McCloskey, Vicente Marco Molina, Beatriz Quirós, Ignacio G Bravo, Silvia de Sanjosé, F Xavier Bosch, Ville N Pimenoff
BACKGROUND: Human papillomavirus (HPV)-related anal cancer lesions are often found adjacent to the squamocolumnar junction (SCJ). We have assessed the histopathology and associated HPV genotypes in anal SCJ lesions in surgically excised anal warts in HIV-negative and -positive patients. METHODS: Histopathology identified 47 squamous intraepithelial lesions (SILs) adjacent to the SCJ amongst a total of 145 cases of clinically diagnosed anal condylomata. The anal SCJ lesions were further analyzed with p16, CK7 and p63 immunohistochemistry and HPV genotyping...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28687439/subsquamous-intestinal-metaplasia-is-common-in-treatment-na%C3%A3-ve-barrett-s-esophagus
#6
Michael J Bartel, Amitabh Srivastava, Stuart Gordon, Richard I Rothstein, Heiko Pohl
BACKGROUND AND AIMS: Barrett's intestinal metaplasia may extend beneath normal squamous epithelium at the squamocolumnar junction (SCJ) and therefore escape surveillance biopsy sampling. The prevalence of subsquamous intestinal metaplasia (SSIM) in patients undergoing Barrett's esophagus (BE) surveillance is unknown. Our aim was to examine the prevalence and distribution of SSIM proximal to the SCJ in patients undergoing BE surveillance. METHODS: We enrolled consecutive patients with biopsy specimen-proven BE...
July 4, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28639968/defining-the-cervical-transformation-zone-and-squamocolumnar-junction-can-we-reach-a-common-colposcopic-and-histologic-definition
#7
Olaf Reich, Sigrid Regauer, W G McCluggage, Christine Bergeron, Charles Redman
Quality assurance and research in colposcopy and cervical pathology require standardized terminologies and reporting. However, clinical and histologic definitions of the cervical transformation zone (TZ) and squamocolumnar junction (SCJ) vary considerably. We aimed to identify areas of agreement and areas where work is required to standardize the definitions of the TZ and the SCJ. We conducted a survey among the board members of the European Federation of Colposcopy member societies and members of the International Society of Gynecological Pathologists...
November 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28455160/long-term-follow-up-results-of-stepwise-radical-endoscopic-resection-for-barrett-s-esophagus-with-early-neoplasia
#8
Kamar Belghazi, Frederike G I van Vilsteren, Bas L A M Weusten, Sybren L Meijer, Jacques J G H M Bergman, Roos E Pouw
BACKGROUND AND AIMS: Stepwise radical endoscopic resection (SRER) has shown to be effective in eradicating Barrett's esophagus (BE) and its associated dysplasia. The aim of this study was to assess the long-term durability after successful SRER for early Barrett's neoplasia. METHODS: Patients treated with SRER for BE ≤5 cm with high-grade dysplasia (HGD) or early cancer (EC) and who had reached complete eradication of intestinal metaplasia (CE-IM) and neoplasia (CE-neo) were included...
April 25, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28357377/chlamydia-trachomatis-genital-infections
#9
REVIEW
Catherine M O'Connell, Morgan E Ferone
Etiology, transmission and protection: Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection (STI) globally. However, C. trachomatis also causes trachoma in endemic areas, mostly Africa and the Middle East, and is a leading cause of preventable blindness worldwide. Epidemiology, incidence and prevalence: The World Health Organization estimates 131 million new cases of C. trachomatis genital infection occur annually. Globally, infection is most prevalent in young women and men (14-25 years), likely driven by asymptomatic infection, inadequate partner treatment and delayed development of protective immunity...
September 5, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28316850/a-report-of-two-cases-of-age-related-changes-in-cervical-morphology-in-postmenopausal-women-with-vaginal-adenosis
#10
Marguerite B Vigliani
This paper presents two cases of women who had extensive vaginal adenosis from prenatal DES exposure, extending almost halfway down the vaginal canal. Both women were followed for decades with annual exams and Pap smears until after menopause. Clinical examination in both cases initially showed an absent pars vaginalis of the cervix, vaginal adenosis, and shallowness of the fornices. Several decades of annual exams showed these stigmata of DES exposure gradually disappear as the upper vagina progressively contracted...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28267445/abdominal-compression-by-waist-belt-aggravates-gastroesophageal-reflux-primarily-by-impairing-esophageal%C3%A2-clearance
#11
David R Mitchell, Mohammad H Derakhshan, Angela A Wirz, Stuart A Ballantyne, Kenneth E L McColl
BACKGROUND & AIMS: Central obesity promotes gastroesophageal reflux, which may be related to increased intra-abdominal pressure. We investigated the effect of increasing abdominal pressure by waist belt on reflux in patients with reflux disease. METHODS: We performed a prospective study of patients with esophagitis (n = 8) or Barrett's esophagus (n = 6); median age was 56 years and median body mass index was 26.8. Proton pump inhibitors were stopped at least 7 days before the study and H2 receptor antagonists were stopped for at least 24 hours before...
June 2017: Gastroenterology
https://www.readbyqxmd.com/read/28212672/cytokeratin7-and-cytokeratin19-expression-in-high-grade-cervical-intraepithelial-neoplasm-and-squamous-cell-carcinoma-and-their-possible-association-in-cervical-carcinogenesis
#12
Hojung Lee, Hyekyung Lee, Yong Kyun Cho
BACKGROUND: High risk human papillomavirus (HR HPV) infects cells at the squamocolumnar junction (SCJ) of the cervix, causing cancer. Cytokeratin (CK)7 is an SCJ marker, and stains cervical neoplasia. CK19 is a binding partner of CK7 and expressed in cervical cancer. Despite this possible association between CK7/CK19 and cervical cancer, not much is known about the mechanism of CK7/CK19 involvement in HR HPV-mediated cervical carcinogenesis. METHODS: We analyzed the expression pattern of CK7, CK19, and p16 by using immunohistochemistry and HPV infection by in situ hybridization in 25 cases of high grade cervical intraepithelial neoplasia (CIN3) and in 30 cases of squamous cell carcinoma (SCC)...
February 17, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/27872404/unique-cellular-lineage-composition-of-the-first-gland-of-the-mouse-gastric-corpus
#13
Andrew O'Neil, Christine P Petersen, Eunyoung Choi, Amy C Engevik, James R Goldenring
The glandular stomach has two major zones: the acid secreting corpus and the gastrin cell-containing antrum. Nevertheless, a single gland lies at the transition between the forestomach and corpus in the mouse stomach. We have sought to define the lineages that make up this gland unit at the squamocolumnar junction. The first gland in mice showed a notable absence of characteristic corpus lineages, including parietal cells and chief cells. In contrast, the gland showed strong staining of Griffonia simplicifolia-II (GSII)-lectin-positive mucous cells at the bases of glands, which were also positive for CD44 variant 9 and Clusterin...
January 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/27825279/the-normal-squamocolumnar-junction-is-circumferentially-even-and-minimal-irregularities-are-manifestations-of-gastroesophageal-acid-reflux
#14
Mats Guerrero Garcia Hall, Jörgen Wenner, Stefan Öberg
BACKGROUND: The macroscopic appearance of the normal squamocolumnar junction (SCJ) is often described as serrated with short projections of columnar mucosa that extend into the esophagus. As studies of the normal SCJ are sparse, the aim of this study was to test the hypothesis that the normal SCJ is even and that irregularities are manifestations of acid reflux. METHOD: Fifty asymptomatic subjects and 149 patients with symptoms suggestive of gastroesophageal reflux disease underwent endoscopy and 48-h pH monitoring with a pH electrode positioned immediately above the SCJ...
March 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27680604/ck7-immunohistochemistry-as-a-predictor-of-cin1-progression-a-retrospective-study-of-patients-from-the-quadrivalent-hpv-vaccine-trials
#15
RANDOMIZED CONTROLLED TRIAL
Anne M Mills, Cherie Paquette, Tatjana Terzic, Philip E Castle, Mark H Stoler
Cervical high-grade squamous intraepithelial lesion (CIN2-3) is thought to arise from a distinct population of cells at the squamocolumnar junction (SCJ). Immunohistochemical (IHC) biomarkers that characterize the SCJ phenotype, including CK7, have been proposed as tools to separate the subset of low-grade squamous intraepithelial lesions (LSILs) (CIN1) that will progress to high-grade squamous intraepithelial lesion from the majority of cases, which will resolve without further intervention. We conducted a retrospective study of CK7 IHC on adjudicated CIN1 tissue from women in the placebo arm of the quadrivalent human papillomavirus (HPV) vaccine trials...
February 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27663505/the-gastric-acid-pocket-is-attenuated-in-h-pylori-infected-subjects
#16
David R Mitchell, Mohammad H Derakhshan, Angela A Wirz, Clare Orange, Stuart A Ballantyne, James J Going, Kenneth E L McColl
OBJECTIVE: Gastric acid secretory capacity in different anatomical regions, including the postprandial acid pocket, was assessed in Helicobacter pylori positive and negative volunteers in a Western population. DESIGN: We studied 31 H. pylori positive and 28 H. pylori negative volunteers, matched for age, gender and body mass index. Jumbo biopsies were taken at 11 predetermined locations from the gastro-oesophageal junction and stomach. Combined high-resolution pH metry (12 sensors) and manometry (36 sensors) was performed for 20 min fasted and 90 min postprandially...
September 2017: Gut
https://www.readbyqxmd.com/read/27639133/interpretation-of-colposcopy-in-population-based-cervical-screening-services-in-north-eastern-italy-an-online-interregional-agreement-study
#17
Paola Garutti, Paolo Cristiani, Gian P Fantin, Francesco Sopracordevole, Silvano Costa, Patrizia Schincaglia, Alessandra Ravaioli, Priscilla Sassoli de Bianchi, Carlo Naldoni, Stefano Ferretti, Lauro Bucchi
OBJECTIVE: An innovative web-based colposcopy quality assurance programme was implemented in population-based cervical screening services in three north-eastern Italian administrative regions with different colposcopists' training background. In this study, the levels of intra- and interregional intercolposcopist diagnostic agreement were evaluated. STUDY DESIGN: Of the 158 registered colposcopists, 125 accessed the website of the programme, logged-in, viewed a posted set of 50 digital colpophotographs selected by an expert steering committee, and classified them for the colposcopic impression, the visibility of the squamocolumnar junction, and the need for biopsy...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27573773/transcommitment-paving-the-way-to-barrett-s-metaplasia
#18
REVIEW
David H Wang, Rhonda F Souza
Barrett's esophagus is the condition in which metaplastic columnar epithelium that predisposes to cancer development replaces stratified squamous epithelium in the distal esophagus. Potential sources for the cell or tissue of origin for metaplastic Barrett's epithelium are reviewed including native esophageal differentiated squamous cells, progenitor cells native to the esophagus located within the squamous epithelium or in the submucosal glands or ducts, circulating bone marrow-derived stem cells, and columnar progenitor cells from the squamocolumnar junction or the gastric cardia that proximally shift into the esophagus to fill voids left by damaged squamous epithelium...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27564523/colposcopy-and-additive-diagnostic-value-of-biopsies-from-colposcopy-negative-areas-to-detect-cervical-dysplasia
#19
Ingrid Baasland, Bjørn Hagen, Christina Vogt, Marit Valla, Pål R Romundstad
INTRODUCTION: We evaluated colposcopy in the routine diagnostic workup of women with abnormal cervical cytology, as well as the diagnostic value of endocervical curettage material and biopsies taken from colposcopy-positive and colposcopy-negative quadrants of the cervix. MATERIAL AND METHODS: This cross-sectional study included 297 nonpregnant women with abnormal cervical cytology and no prior treatment for cervical dysplasia or cancer. All women underwent gynecological examination, colposcopy, endocervical curettage, and had cervical biopsies taken...
November 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27506510/small-lesion-size-measured-by-colposcopy-may-predict-absence-of-cervical-intraepithelial-neoplasia-in-a-large-loop-excision-of-the-transformation-zone-specimen
#20
M Munmany, L Marimon, M Cardona, R Nonell, M Juiz, R Astudillo, J Ordi, A Torné, M Del Pino
OBJECTIVE: To evaluate whether colposcopic measurement of the lesion size at diagnosis and/or human papillomavirus (HPV) genotyping can predict the absence of dysplasia in a large loop excision of the transformation zone (LLETZ) specimen in women treated for squamous intraepithelial lesions/cervical intraepithelial neoplasia (SIL/CIN). DESIGN: Prospective observational study. SETTING: Tertiary university hospital. POPULATION: A cohort of 116 women who underwent LLETZ because of biopsy-proven low-grade SIL/CIN that had persisted for 2 years, or because of a high-grade SIL/CIN diagnosed in the referral visit and squamocolumnar junction completely visible (types 1 or 2, according to the International Federation of Cervical Pathology and Colposcopy, IFCPC)...
August 9, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
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