Jingshi Wang, Min Su, Na Wei, Huanyu Yan, Jia Zhang, Yi Gong, Lin Wu, Dina Suolitiken, Yubo Pi, Deli Song, Leilei Chen, Huan Liu, Shuo Yang, Xi Wang, Zhao Wang
Chronic active Epstein-Barr Virus (EBV) disease (CAEBV) is lethal syndrome due to persistent EBV infection. When diagnosed as CAEBV, EBV infection was observed in multiple hematopoietic lineages, but the etiology of CAEBV is still elusive. Bone marrow and peripheral cells derived from five CAEBV patients, one EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH) patient, and two healthy controls were analyzed. Multiple assays were applied to identify and characterize EBV-infected cells, including quantitative PCR (qPCR), PrimeFlow and single-cell RNA-sequencing (scRNA-seq)...
October 12, 2023: Blood