Dongchen Yuan, Jing Hu, Xiaoman Ju, Eva Maria Putz, Simin Zheng, Stephane Koda, Guowei Sun, Xiaoran Deng, Zhipeng Xu, Wei Nie, Yang Zhao, Xianyang Li, William C Dougall, Simin Shao, Yan Chen, Renxian Tang, Kuiyang Zheng, Juming Yan
Neurotransmitter receptors are increasingly recognized to play important roles in anti-tumor immunity. The expression of the ion channel N-methyl-D-aspartate receptor (NMDAR) on macrophages was reported, but the role of NMDAR on macrophages in the tumor microenvironment (TME) remains unknown. Here, we show that the activation of NMDAR triggered calcium influx and reactive oxygen species production, which fueled immunosuppressive activities in tumor-associated macrophages (TAMs) in the hepatocellular sarcoma and fibrosarcoma tumor settings...
November 21, 2023: Proceedings of the National Academy of Sciences of the United States of America