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https://www.readbyqxmd.com/read/29761262/correction-to-comparison-of-early-morbidity-and-mortality-between-sleeve-gastrectomy-and-gastric-bypass-in-high-risk-patients-for-liver-disease-analysis-of-american-college-of-surgeons-national-surgical-quality-improvement-program
#1
Mohamad A Minhem, Sali F Sarkis, Bassem Y Safadi, Souha A Fares, Ramzi S Alami
The authors regret that some of the article text, which was in the original manuscript and was intended for and addressed to the reviewers during the review process of this article, was mistakenly overlooked during the proofs stage and remains in the published article.
May 14, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29746150/biomechanical-comparison-of-anatomic-and-extra-anatomic-reconstruction-techniques-using-local-grafts-for-chronic-instability-of-the-acromioclavicular-joint
#2
Malo Le Hanneur, Andrew Thoreson, Damien Delgrande, Thibault Lafosse, Jean-David Werthel, Philippe Hardy, Bassem Elhassan
BACKGROUND: Anatomic reconstruction techniques are increasingly used to address cases of acromioclavicular (AC) joint chronic instability. These usually involve an additional surgical site for autograft harvesting or an allograft. PURPOSE: To describe a triple-bundle (TB) anatomic reconstruction using on-site autografts, the semiconjoint tendon (SCT) and the coracoacromial ligament (CAL), and compare its primary stability to the native AC joint ligamentous complex and to a modified Weaver-Dunn (WD) reconstruction...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29729290/anticonvulsant-evaluation-of-novel-non-imidazole-histamine-h-3-r-antagonists-in-different-convulsion-models-in-rats
#3
Alaa Alachkar, Gniewomir Latacz, Agata Siwek, Annamaria Lubelska, Ewelina Honkisz, Anna Gryboś, Dorota Łażewska, Jadwiga Handzlik, Holger Stark, Katarzyna Kiec-Kononowicz, Bassem Sadek
Novel non-imidazole histamine H3 receptor (H3R) antagonists (2-8) were developed and assessed for in-vitro antagonist binding affinities at the human histamine H1-H4R. These novel H3R antagonists (2-8) were examined in-vivo for anticonvulsant effects in three different convulsion models in male adult rats. Compound 6 significantly and dose-dependently exhibited decreased duration of tonic hind limb extension (THLE) in the maximal electroshock (MES)- and fully protected animals against pentylenetetrazole (PTZ)-induced convulsion, following acute systemic administration (5, 10, and 20 mg/kg, i...
May 2, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29723785/synthesis-and-biological-activity-of-novel-tert-butyl-and-tert-pentylphenoxyalkyl-piperazine-derivatives-as-histamine-h-3-r-ligands
#4
Katarzyna Szczepańska, Tadeusz Karcz, Szczepan Mogilski, Agata Siwek, Kamil J Kuder, Gniewomir Latacz, Monika Kubacka, Stefanie Hagenow, Annamaria Lubelska, Agnieszka Olejarz, Magdalena Kotańska, Bassem Sadek, Holger Stark, Katarzyna Kieć-Kononowicz
As a continuation of our search for novel histamine H3 receptor ligands, a series of twenty four new tert-butyl and tert-pentyl phenoxyalkylamine derivatives (2-25) was synthesized. Compounds with three to four carbon atoms alkyl chain spacer were evaluated for their binding properties at human histamine H3 receptor (hH3 R). The highest affinities were observed for 4-pyridyl derivatives 4, 10, 16 and 22 (Ki  = 16.0-120 nM). As it has been shown in docking studies, those specific heteroaromatic 4-N piperazine substituents might interact with one of the key receptor interacting amino acids...
April 25, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29717369/molecular-identification-of-trichodina-compacta-van-as-and-basson-1989-ciliophora-peritrichia-from-cultured-oreochromis-niloticus-in-egypt-and-its-impact-on-immune-responses-and-tissue-pathology
#5
Nevien K Abdelkhalek, Mohamed A El-Adl, Mohamed F Salama, Bassem Elmishmishy, Mayar O Ali, Ahmed El-Ashram, Mohamed F Hamed, Moustafa A Al-Araby
Trichodinids are peritrichous ciliated protozoa that affect both wild and cultured fishes. Several Trichodina species have low host specificity and are morphologically distinct, facilitating their identification based primarily on the presence of adhesive discs and the number of attached denticles. A trichodinid species named Trichodina compacta was first reported by Van As and Basson (1989) (Protozoa: Ciliophora: Peritrichia). However, in trichodinid infestations, morphological characteristics are insufficient for identifying the infesting species...
May 1, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29708225/effectiveness-of-alternative-dose-fingolimod-for-multiple-sclerosis
#6
Erin E Longbrake, Daniel Kantor, Siddharama Pawate, Michael J Bradshaw, Gloria von Geldern, Salim Chahin, Anne H Cross, Becky J Parks, Marc Rice, Samia J Khoury, Bassem Yamout, Maya Zeineddine, Shira Russell-Giller, Ana Caminero-Rodriguez, Keith Edwards, Ellen Lathi, Danita VanderKodde, William Meador, Regina Berkovich, Lily Ge, Tamar E Bacon, Ilya Kister
Background: Fingolimod is a daily oral medication used to treat relapsing multiple sclerosis (MS). Clinicians often adopt less frequent dosing for patients with profound drug-induced lymphopenia or other adverse events. Data on the effectiveness of alternate dose fingolimod are limited. Methods: We conducted a multicenter, retrospective, observational study at 14 sites and identified 170 patients with MS taking alternate doses of fingolimod for ≥1 month. Clinical and radiologic outcomes were collected and compared during daily and alternate fingolimod dosing...
April 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29696572/comparison-of-early-morbidity-and-mortality-between-sleeve-gastrectomy-and-gastric-bypass-in-high-risk-patients-for-liver-disease-analysis-of-american-college-of-surgeons-national-surgical-quality-improvement-program
#7
Mohamad A Minhem, Sali F Sarkis, Bassem Y Safadi, Souha A Fares, Ramzi S Alami
INTRODUCTION: Chronic liver disease is prevalent in obese patients presenting for bariatric surgery and is associated with increased postoperative morbidity and mortality (M&M). There are no comparative studies on the safety of different types of bariatric operations in this subset of patients. OBJECTIVE: The aim of this study is to compare the 30-day postoperative M&M between laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-Y-gastric bypass (LRYGB) in the subset of patients with a model of end-stage liver disease (MELD) score ≥ 8...
April 25, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29689308/the-influence-of-temperature-stress-on-the-physiology-of-the-atlantic-surfclam-spisula-solidissima
#8
Jesse Hornstein, Emmanuelle Pales Espinosa, Robert M Cerrato, Kamazima M M Lwiza, Bassem Allam
Atlantic surfclam populations have significantly declined in state and federal waters from the south shore of Long Island, New York to the Delmarva Peninsula since the early 2000s. Previous studies have demonstrated that surfclams in this geographic range show signs of physiological stress, suggested to be a result of increasing ocean temperatures. In this study, we examined the effect of 2 temperature regimes (19 °C and 23 °C) on surfclam physiology. These temperatures were chosen because they represent maximal (23 °C) and minimal (19 °C) temperatures prevailing in New York clamming areas during summer...
April 21, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29685389/arthroplasty-for-glenohumeral-arthritis-in-shoulders-with-a-previous-bristow-or-latarjet-procedure
#9
Laurent B Willemot, Bassem T Elhassan, John W Sperling, Robert H Cofield, Joaquin Sánchez-Sotelo
BACKGROUND: Coracoid transfer has become increasingly popular for recurrent anterior shoulder instability. Despite the success, glenohumeral arthropathy develops in some patients. Arthroplasty in this population is complicated by altered anatomy, scarring, and retained hardware. This study evaluated shoulder arthroplasty in patients with a previous Latarjet or Bristow procedure. METHODS: Between 1980 and 2014, 33 patients underwent shoulder arthroplasty after coracoid transfer...
April 20, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29665077/gliovascular-changes-precede-white-matter-damage-and-long-term-disorders-in-juvenile-mild-closed-head-injury
#10
Beatriz Rodriguez-Grande, Andre Obenaus, Aleksandra Ichkova, Justine Aussudre, Thomas Bessy, Elodie Barse, Bassem Hiba, Gwénaëlle Catheline, Grégory Barrière, Jerome Badaut
Traumatic brain injury (TBI) is a leading cause of hospital visits in pediatric patients and often leads to long-term disorders even in cases of mild severity. White matter (WM) alterations are commonly observed in patients months or years after the injury assessed by magnetic resonance imaging (MRI), but little is known about WM pathophysiology early after mild pediatric TBI. To evaluate the status of the gliovascular unit in this context, mild TBI was induced in postnatal-day 17 mice using a closed head injury model with two grades of severity (G1, G2)...
April 17, 2018: Glia
https://www.readbyqxmd.com/read/29659379/bony-reconstruction-of-the-anterior-glenoid-rim
#11
Laurent B Willemot, Bassem T Elhassan, Olivier Verborgt
Recurrent anterior shoulder instability is associated with glenohumeral bone loss. Glenoid deficiency compromises the concavity-compression mechanism. Medial Hill-Sachs lesions can result in an off-track humeral position. Anterior glenoid reconstruction or augmentation prevents recurrence by addressing the pathomechanics. In Bristow and Latarjet procedures, the coracoid process is harvested for conjoint tendon transfer, capsular reinforcement, and glenoid rim restoration. Complications and the nonanatomic nature of the procedure have spurred research on graft sources...
April 13, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29629143/exciton-coupling-in-diketopyrrolopyrrole-helicene-derivatives-leads-to-red-and-near-infrared-circularly-polarized-luminescence
#12
Kais Dhbaibi, Ludovic Favereau, Monika Srebro-Hooper, Marion Jean, Nicolas Vanthuyne, Francesco Zinna, Bassem Jamoussi, Lorenzo Di Bari, Jochen Autschbach, Jeanne Crassous
Molecular and macromolecular chiral π-conjugated diketopyrrolopyrrole (DPP)-helicene derivatives were prepared and their chiroptical properties examined experimentally and theoretically. Exciton coupling leads to red and near-infrared circularly polarized absorption and luminescence arising from the achiral DPP units in the helical environment, highlighting an interesting synergy between the chiral helicene and the organic dye.
January 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29627946/role-of-routine-abdominal-ultrasound-before-bariatric-surgery-review-of-937-patients
#13
Bassem M Abou Hussein, Ali Khammas, Maryam Makki, Marwah Makki, Usama Al Bastaki, Alya Al Mazrouei, Faisal S Badri
INTRODUCTION: Routine use of preoperative abdominal ultrasound for patients undergoing bariatric surgery is controversial. Despite that some physicians routinely implement it, others consider it unnecessary and not cost effective because it does not have a clear clinical significance in the preparation of bariatric patients. AIM OF THE STUDY: To investigate whether routine abdominal ultrasound prior to bariatric surgery affects the surgical plan or not. PATIENTS AND METHODS: We reviewed medical records of patients with abdominal ultrasound before bariatric surgery in Rashid Hospital between June 2014 and December 2016...
April 7, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29613929/long-term-outcomes-of-glenohumeral-arthrodesis
#14
Eric R Wagner, Richard McLaughlin, Shumaila Sarfani, Robert H Cofield, John W Sperling, Joaquin Sanchez-Sotelo, Bassem T Elhassan
BACKGROUND: Glenohumeral arthrodesis is associated with a high rate of complications. Although patients experience reasonable pain relief and shoulder stability, they experience marked limitations in their upper-extremity function. The purpose of this study was to examine the clinical outcomes of glenohumeral arthrodesis. METHODS: Twenty-nine patients with 29 affected shoulders underwent primary glenohumeral arthrodesis between 1992 and 2009. Surgical indications included rotator cuff arthropathy and pseudoparalysis (n = 7), neurologic injuries (n = 12), chronic infection (n = 3), recurrent dislocations (n = 3), and proximal humeral or shoulder girdle tumors (n = 4)...
April 4, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29609028/identification-of-clam-plasma-proteins-that-bind-its-pathogen-quahog-parasite-unknown
#15
Rachel Hartman, Emmanuelle Pales Espinosa, Bassem Allam
The hard clam (Mercenaria mercenaria) is among the most economically-important marine species along the east coast of the United States, representing the first marine resource in several Northeastern states. The species is rather resilient to infections and the only important disease of hard clams results from an infection caused by Quahog Parasite Unknown (QPX), a protistan parasite that can lead to significant mortality events in wild and aquacultured clam stocks. Though the presence of QPX disease has been documented since the 1960s, little information is available on cellular and molecular interactions between the parasite and the host...
March 30, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29605518/shoulder-arthroplasty-for-sequelae-of-obstetrical-brachial-plexus-injury
#16
Jean-David Werthel, Bradley Schoch, Mark Frankle, Robert Cofield, Bassem T Elhassan
PURPOSE: Shoulder arthroplasty following obstetrical brachial plexus injury (OBPI) is technically challenging because glenoid morphology, muscle balance, and humeral version are substantially altered compared with the neurologically intact shoulder. The purpose of this study is to report the outcome of shoulder arthroplasty in a group of patients with end-stage arthritis secondary to OBPI. MATERIALS AND METHODS: Seven patients with OBPI and secondary glenohumeral arthritis were treated with shoulder arthroplasty between 1976 and 2014...
March 29, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29605249/purification-biochemical-and-molecular-characterization-of-novel-protease-from-bacillus-licheniformis-k7a
#17
Raziqa Hadjidj, Abdelmalek Badis, Sondes Mechri, Kamel Eddouaouda, Lamia Khelouia, Rachid Annane, Mohamed El Hattab, Bassem Jaouadi
A novel extracellular alkaline protease, called SAPHM, from Bacillus licheniformis K7A was purified by four steps procedure involving heat treatment (30 min at 70 °C) followed by ammonium sulfate precipitation (40-70%)-dialysis, UNO Q-12 FPLC, and ZORBAX PSM 300 HPLC, and submitted to biochemical characterization assays. The purified enzyme is a monomer of molecular mass of 30,325.12 Da. Its sequence of the 26 NH2 -terminal residues showed high homology with those of Bacillus proteases. The purified enzyme was optimally active at pH 10 and temperature 70 °C...
March 29, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29576424/a-temporal-transcriptional-switch-governs-stem-cell-division-neuronal-numbers-and-maintenance-of-differentiation
#18
Natalia Mora, Carlos Oliva, Mark Fiers, Radoslaw Ejsmont, Alessia Soldano, Ting-Ting Zhang, Jiekun Yan, Annelies Claeys, Natalie De Geest, Bassem A Hassan
The importance of producing the correct numbers of neurons during development is illustrated by both evolutionary enhancement of cognitive capacities in larger brains, and developmental disorders of brain size. In humans, increased neuronal numbers during development is speculated to partly derive from a unique subtype of neural stem cells (NSCs) that undergo a phase of expansion through symmetric self-amplifying divisions before generating neurons. Symmetric amplification also appears to underlie adult neural stem maintenance in the mouse...
March 20, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29556428/improving-changes-in-physical-sensory-and-texture-properties-of-cake-supplemented-with-purified-amylase-from-fenugreek-trigonella-foenum-graecum-seeds
#19
Bassem Khemakhem, Slim Smaoui, Hanen El Abed, Imen Fendri, Hajer Hammami, Mohamed Ali Ayadi
Three different concentrations of a purified maltogenic amylase (FSA) from fenugreek ( Trigonella foenum graecum ) seeds were incorporated into the cake formulation. The addition of FSA at 0.003, 0.005 and 0.01 U/g of cake increased the loaf volume, the number of holes (gas cells), and water absorption. Textural study revealed an improvement of the cake quality, resulting in the decrease of hardness and the increase of cohesion. Environmental scanning electron microscopy was performed on different cakes to evaluate the influence of amylase activity on microstructure...
March 2018: 3 Biotech
https://www.readbyqxmd.com/read/29556070/vitamin-d-alleviates-lead-induced-renal-and-testicular-injuries-by-immunomodulatory-and-antioxidant-mechanisms-in-rats
#20
Mohammad A BaSalamah, Abdelghany Hassan Abdelghany, Mohamed El-Boshy, Jawwad Ahmad, Shakir Idris, Bassem Refaat
This study measured the effects of vitamin D (VD) supplementation on the underlying molecular pathways involved in renal and testicular damage induced by lead (Pb) toxicity. Thirty two adult male Wistar rats were divided equally into four groups that were treated individually or simultaneously, except the negative control, for four weeks with lead acetate in drinking water (1,000 mg/L) and/or intramuscular VD (1,000 IU/kg; 3 days/week). Pb toxicity markedly reduced serum VD and Ca2+ , induced substantial renal and testicular injuries with concomitant significant alterations in the expression of VD metabolising enzymes, its receptor and binding protein, and the calcium sensing receptor...
March 19, 2018: Scientific Reports
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