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https://www.readbyqxmd.com/read/28923563/characterization-antioxidant-and-antiglycation-properties-of-polysaccharides-extracted-from-the-medicinal-halophyte-carpobrotus-edulis-l
#1
Jawhar Hafsa, Khaoula Mkadmini Hammi, Didier Le Cerf, Khalifa Limem, Hatem Majdoub, Bassem Charfeddine
In this study, Box-Behnken design was used to optimize the ultrasonic extraction of Carpobrotus edulis polysaccharides (CEP), and the effect of time, extraction temperature and water to material ratio was evaluated. Optimum conditions were 1.77h, 78.0°C and 33.04mL/g to improved CEP yield (7.84%), which is in good agreement with the predicted yield 7.77%. Then, the physico-chemical, antioxidant and antiglycation properties of optimized CEP were studied, and the total sugar and galacturonic acid content were 89...
September 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28888208/prophetic-medicine-as-potential-functional-food-elements-in-the-intervention-of-cancer-a-review
#2
REVIEW
Bassem Y Sheikh, Md Moklesur Rahman Sarker, Muhamad Noor Alfarizal Kamarudin, Amin Ismail
Amounting scientific evidences have revealed the antitumor, antimetastatic, antiangiogenic, antiproliferative, chemopreventive and neo-adjuvant efficacy of Prophetic Medicine in various in vitro, in vivo and clinical cancer models. Prophetic Medicine includes plants, dietary materials or spices that were used as remedy recipes and nutrition by the great Prophet Mohammed (peace be upon him) to treat various ailments. Prophetic medicine is the total authentic Hadith narrated by the Prophet (PBUH) in relation to medicine, whether Qur'anic verses or honourable Prophetic Hadith...
September 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28858267/novel-selective-estrogen-receptor-ligand-conjugates-incorporating-endoxifen-combretastatin-and-cyclofenil-combretastatin-hybrid-scaffolds-synthesis-and-biochemical-evaluation
#3
Patrick M Kelly, Niall O Keely, Sandra A Bright, Bassem Yassin, Gloria Ana, Darren Fayne, Daniela M Zisterer, Mary J Meegan
Nuclear receptors such as the estrogen receptors (ERα and ERβ) modulate the effects of the estrogen hormones and are important targets for design of innovative chemotherapeutic agents for diseases such as breast cancer and osteoporosis. Conjugate and bifunctional compounds which incorporate an ER ligand offer a useful method of delivering cytotoxic drugs to tissue sites such as breast cancers which express ERs. A series of novel conjugate molecules incorporating both the ER ligands endoxifen and cyclofenil-endoxifen hybrids covalently linked to the antimitotic and tubulin targeting agent combretastatin A-4 were synthesised and evaluated as ER ligands...
August 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28827133/biochemical-characterization-of-a-novel-thermostable-chitinase-from-hydrogenophilus-hirschii-strain-kb-dz44
#4
Khelifa Bouacem, Hassiba Laribi-Habchi, Sondes Mechri, Hocine Hacene, Bassem Jaouadi, Amel Bouanane-Darenfed
An extracellular acido-thermostable endo-chitinase (called ChiA-Hh59) from thermophilic Hydrogenophilus hirschii strain KB-DZ44, was purified and characterized. The maximum chitinase activity recorded after 36-h of incubation at 60°C was 3000U/ml. Pure enzyme was obtained after heat and acidic treatment, precipitation by ammonium sulphate and acetone, respectively, followed by sequential column chromatographies on Sephacryl S-200 and Mono Q-Sepharose. Based on MALDI-TOF/MS analysis, the purified enzyme is a monomer with a molecular mass of 59103...
August 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28820907/positive-regulatory-interactions-between-yap-and-hedgehog-signalling-in-skin-homeostasis-and-bcc-development-in-mouse-skin-in-vivo
#5
Bassem Akladios, Veronica Mendoza Reinoso, Jason E Cain, Taopeng Wang, Duncan L Lambie, D Neil Watkins, Annemiek Beverdam
Skin is a highly plastic tissue that undergoes tissue turnover throughout life, but also in response to injury. YAP and Hedgehog signalling play a central role in the control of epidermal stem/progenitor cells in the skin during embryonic development, in postnatal tissue homeostasis and in skin carcinogenesis. However, the genetic contexts in which they act to control tissue homeostasis remain mostly unresolved. We provide compelling evidence that epidermal YAP and Hedgehog/GLI2 signalling undergo positive regulatory interactions in the control of normal epidermal homeostasis and in basal cell carcinoma (BCC) development, which in the large majority of cases is caused by aberrant Hedgehog signalling activity...
2017: PloS One
https://www.readbyqxmd.com/read/28813685/purification-and-characterization-of-two-novel-peroxidases-from-the-dye-decolorizing-fungus-bjerkandera-adusta-strain-cx-9
#6
Khelifa Bouacem, Hatem Rekik, Nadia Zaraî Jaouadi, Bilal Zenati, Sidali Kourdali, Mohamed El Hattab, Abdelmalek Badis, Rachid Annane, Samir Bejar, Hocine Hacene, Amel Bouanane-Darenfed, Bassem Jaouadi
Two extracellular peroxidases from Bjerkandera adusta strain CX-9, namely a lignin peroxidase (called LiP BA45) and manganese peroxidase (called MnP BA30), were purified simultaneously by applying successively, ammonium sulfate precipitation-dialysis, Mono-S Sepharose anion-exchange and Sephacryl S-200 gel filtration and biochemically characterized. The sequence of their NH2-terminal amino acid residues showed high homology with those of fungi peroxidases. MALDI-TOF/MS analysis revealed that the purified enzymes MnP BA30 and LiP BA45 were a monomers with a molecular masses 30125...
August 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28776151/comparison-of-outcomes-between-laparoscopic-roux-en-y-gastric-bypass-and-sleeve-gastrectomy-in-a-lebanese-bariatric-surgical-practice
#7
Hanaa Dakour Aridi, Georges Khazen, Bassem Y Safadi
PURPOSE: Long-term studies on the outcomes of bariatric surgery are still limited in the Middle East. The aim of this study is to compare the outcomes of laparoscopic Roux-en-Y gastric bypass (LRYGB) and sleeve gastrectomy (LSG) up to 5 years of follow-up. MATERIALS AND METHODS: A retrospective analysis of patients who underwent LRYGB and LSG was performed. The primary outcome was weight loss. Postoperative complications, operative time, and hospital length of stay were secondary outcomes...
August 3, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28747148/letter-to-the-editor
#8
Bassem I Yamout, Maya M Zeineddine
No abstract text is available yet for this article.
July 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28736725/intraoperative-radiation-therapy-a-promising-treatment-modality-in-head-and-neck-cancer
#9
REVIEW
Lara Hilal, Karine A Al Feghali, Paul Ramia, Ibrahim Abu Gheida, Jean-Pierre Obeid, Wassim Jalbout, Bassem Youssef, Fady Geara, Youssef H Zeidan
Every year, almost 62,000 are diagnosed with a head and neck cancer (HNC) and 13,000 will succumb to their disease. In the primary setting, intraoperative radiation therapy (IORT) can be used as a boost in select patients in order to optimize local control. Addition of external beam radiation to limited volumes results in improved disease control over surgery and IORT alone. In the recurrent setting, IORT can improve outcomes from salvage surgery especially in patients previously treated with external beam radiation...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28718308/ulnar-shortening-versus-distal-radius-corrective-osteotomy-in-the-management-of-ulnar-impaction-after-distal-radius-malunion
#10
William R Aibinder, Ali Izadpanah, Bassem T Elhassan
BACKGROUND: Distal radius malunions lead to functional deficits. This study compares isolated ulnar shortening osteotomy (USO) to distal radius osteotomy (DRO) for the treatment of ulnar impaction syndrome following distal radius malunion. METHODS: We retrospectively reviewed 11 patients with extra-articular distal radius malunions treated for ulnar impaction with isolated USO. This group was compared to a 1:1 age- and sex-matched cohort treated with isolated DRO for the same indication...
January 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28705650/shoulder-function-in-patients-with-deltoid-paralysis-and-intact-rotator-cuff
#11
J-D Werthel, J Bertelli, B T Elhassan
INTRODUCTION/HYPOTHESIS: The purpose of this study is to determine the mid/long term shoulder function in patients with complete deltoid paralysis and intact rotator cuff. 27 patients with at least 2-years FU were included. MATERIALS AND METHODS: Outcome measures included pain, range of motion (including the swallowtail test STT), deltoid extension lag test DELT and Bertelli test), subjective fatigability using the injured shoulder and postoperative modified Neer ratings...
July 10, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28695460/inversion-technique-for-the-removal-of-partially-covered-self-expandable-metallic-stents
#12
Christine Hill, Bassem K Khalil, Sindhu Barola, Abhishek Agnihotri, Robert A Moran, Yen-I Chen, Saowanee Ngamruengphong, Vikesh K Singh, Leigh A Frame, Michael A Schweitzer, Thomas H Magnuson, Mouen A Khashab, Patrick I Okolo, Vivek Kumbhari
BACKGROUND AND AIMS: Partially covered self-expandable metallic stents (PCSEMS), although an effective treatment for anastomotic/staple line leaks and strictures, can be difficult to remove. This study examines the effectiveness of the inversion technique for the removal of PCSEMS in the treatment of leaks and strictures that occurred post-sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). METHODS: Consecutive patients who underwent PCSEMS removal for a leak and/or stricture post-SG or RYGB between July 2013 and December 2016 at the Johns Hopkins Medical Institutions were reviewed...
July 10, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28656114/a-mass-of-pancreatic-and-gastric-heterotopia-causing-a-small-bowel-obstruction-in-a-61-year-old-male
#13
Majd Alfrejat, Bassem Khalil, Jordan Jackobs, William Anderson, Jennifer Eschbacher
Heterotopic tissue is a congenital anomaly that has been previously reported. Gastric and pancreatic heterotopia are among the most studied ones. Herein, we describe a case of a combined pancreatic and gastric heterotopia that formed a mass and caused a small intestine obstruction in a 61-year-old male. We also did a brief literature review of cases with gastric and pancreatic heterotopia in adult patients.
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/28643359/an-open-8-channel-parallel-transmission-coil-for-static-and-dynamic-7t-mri-of-the-knee-and-ankle-joints-at-multiple-postures
#14
Jin Jin, Ewald Weber, Aurelien Destruel, Kieran O'Brien, Bassem Henin, Craig Engstrom, Stuart Crozier
PURPOSE: We present the initial in vivo imaging results of an open architecture eight-channel parallel transmission (pTx) transceive radiofrequency (RF) coil array that was designed and constructed for static and dynamic 7T MRI of the knee and ankle joints. METHODS: The pTx coil has a U-shaped dual-row configuration (200 mm overall length longitudinally) that allows static and dynamic imaging of the knee and ankle joints at various postures and during active movements...
June 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28590378/increasing-body-mass-index-is-associated-with-worse-outcomes-after-shoulder-arthroplasty
#15
Eric R Wagner, Matthew T Houdek, Cathy Schleck, William S Harmsen, Joaquin Sanchez-Sotelo, Robert Cofield, John W Sperling, Bassem T Elhassan
BACKGROUND: Although obesity is associated with increased complication rates after lower-extremity arthroplasty, there is a relative paucity of studies examining the effect of body mass index (BMI) on shoulder arthroplasty. The purpose of this investigation was to evaluate the effect of BMI on implant survival and the rate of complications after shoulder arthroplasty. METHODS: Using an institutional total joint registry, 4,567 consecutive shoulder arthroplasty cases from 1970 to 2013 were studied...
June 7, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28576905/cmv-and-bkpyv-infections-in-renal-transplant-recipients-receiving-an-mtor-inhibitor-based-regimen-versus-a-cni-based-regimen-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
Samir G Mallat, Bassem Y Tanios, Houssam S Itani, Tamara Lotfi, Ciaran McMullan, Steven Gabardi, Elie A Akl, Jamil R Azzi
BACKGROUND AND OBJECTIVES: The objective of this meta-analysis is to compare the incidences of cytomegalovirus and BK polyoma virus infections in renal transplant recipients receiving a mammalian target of rapamycin inhibitor (mTOR)-based regimen compared with a calcineurin inhibitor-based regimen. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a comprehensive search for randomized, controlled trials up to January of 2016 addressing our objective. Other outcomes included acute rejection, graft loss, serious adverse events, proteinuria, wound-healing complications, and eGFR...
August 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28554717/phenylalanine-derivatives-with-modulating-effects-on-human-%C3%AE-1-glycine-receptors-and-anticonvulsant-activity-in-strychnine-induced-seizure-model-in-male-adult-rats
#17
Bassem Sadek, Murat Oz, Syed M Nurulain, Petrilla Jayaprakash, Gniewomir Latacz, Katarzyna Kieć-Kononowicz, Ewa Szymańska
The critical role of α1-glycine receptor (α1-GLYRs) in pathological conditions such as epilepsy is well known. In the present study, structure-activity relations for a series of phenylalanine derivatives carrying selected hydrogen bond acceptors were investigated on the functional properties of human α1-GLYR expressed in Xenopus oocytes. The results indicate that one particular substitution position appeared to be of special importance for control of ligand activity. Among tested ligands (1-8), the biphenyl derivative (2) provided the most promising antagonistic effect on α1-GLYRs, while its phenylbenzyl analogue (5) exhibited the highest potentiation effect...
May 26, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28536383/design-synthesis-and-biochemical-evaluation-of-novel-selective-estrogen-receptor-ligand-conjugates-incorporating-an-endoxifen-combretastatin-hybrid-scaffold
#18
Niall O Keely, Miriam Carr, Bassem Yassin, Gloria Ana, David G Lloyd, Daniela Zisterer, Mary J Meegan
Nuclear-receptors are often overexpressed in tumours and can thereby be used as targets when designing novel selective chemotherapeutic agents. To date, many conjugates incorporating an estrogen receptor (ER) ligand have been synthesised in order to direct chemical agents to tissue sites containing ERs. A series of ER ligand conjugates were synthesised incorporating an antagonistic ER ligand scaffold based on endoxifen, covalently-bound via an amide linkage to a variety of combretastatin-based analogues, which may act as antimitotic agents...
July 20, 2016: Biomedicines
https://www.readbyqxmd.com/read/28469422/seroprevalence-of-asymptomatic-dengue-virus-infection-and-its-antibodies-among-healthy-eligible-saudi-blood-donors-findings-from-holy-makkah-city
#19
Ahmed M Ashshi, Saad Alghamdi, Adel G El-Shemi, Sabir Almdani, Bassem Refaat, Amr M Mohamed, Hani O Ghazi, Esam I Azhar, Faisal A Al-Allaf
BACKGROUND: Threat to blood transfusion-transmitted dengue virus (DENV) and its antibodies has recently emerged worldwide. Dengue fever is an endemic disease in Saudi Arabia, particularly in its Western region. The aim of this study was to estimate the seroprevalence of asymptomatic DENV infection and its antibodies among eligible Saudi blood donors. METHODS: Serum samples from 910 healthy/eligible adult male Saudi blood donors, who reside in Holy Makkah City of Saudi Arabia, were collected between March 2015 and August 2016 and screened for the detection of DENV nonstructural protein 1 (NS1) antigen and anti-DENV IgM and IgG antibodies using commercial enzyme-linked immunosorbent assay kits (Panbio, Brisbane, QLD, Australia)...
2017: Virology: Research and Treatment
https://www.readbyqxmd.com/read/28455802/gastroesophageal-reflux-disease-after-laparoscopic-sleeve-gastrectomy-with-concomitant-hiatal-hernia-repair-an-unresolved-question
#20
Hanaa Dakour Aridi, Mohammad Asali, Tarek Fouani, Ramzi S Alami, Bassem Y Safadi
PURPOSE: The effectiveness of the concomitant repair of hiatal hernia (HHR) during laparoscopic sleeve gastrectomy (LSG) in reducing gastroesophageal reflux disease (GERD) symptoms is still unclear. The aim of this study is to assess the effect of concomitant HHR on postoperative GERD symptoms in our patient population. MATERIALS AND METHODS: A retrospective review of patients who underwent LSG with or without HHR between 2011and 2014 was performed. Pre- and postoperative GERD symptoms were assessed at different time intervals until a maximum of 2 years after the surgery...
April 28, 2017: Obesity Surgery
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