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https://www.readbyqxmd.com/read/28813685/purification-and-characterization-of-two-novel-peroxidases-from-the-dye-decolorizing-fungus-bjerkandera-adusta-strain-cx-9
#1
Khelifa Bouacem, Hatem Rekik, Nadia Zaraî Jaouadi, Bilal Zenati, Sidali Kourdali, Mohamed El Hattab, Abdelmalek Badis, Rachid Annane, Samir Bejar, Hocine Hacene, Amel Bouanane-Darenfed, Bassem Jaouadi
Two extracellular peroxidases from Bjerkandera adusta strain CX-9, namely a lignin peroxidase (called LiP BA45) and manganese peroxidase (called MnP BA30), were purified simultaneously by applying successively, ammonium sulfate precipitation-dialysis, Mono-S Sepharose anion-exchange and Sephacryl S-200 gel filtration and biochemically characterized. The sequence of their NH2-terminal amino acid residues showed high homology with those of fungi peroxidases. MALDI-TOF/MS analysis revealed that the purified enzymes MnP BA30 and LiP BA45 were a monomers with a molecular masses 30125...
August 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28776151/comparison-of-outcomes-between-laparoscopic-roux-en-y-gastric-bypass-and-sleeve-gastrectomy-in-a-lebanese-bariatric-surgical-practice
#2
Hanaa Dakour Aridi, Georges Khazen, Bassem Y Safadi
PURPOSE: Long-term studies on the outcomes of bariatric surgery are still limited in the Middle East. The aim of this study is to compare the outcomes of laparoscopic Roux-en-Y gastric bypass (LRYGB) and sleeve gastrectomy (LSG) up to 5 years of follow-up. MATERIALS AND METHODS: A retrospective analysis of patients who underwent LRYGB and LSG was performed. The primary outcome was weight loss. Postoperative complications, operative time, and hospital length of stay were secondary outcomes...
August 3, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28747148/letter-to-the-editor
#3
Bassem I Yamout, Maya M Zeineddine
No abstract text is available yet for this article.
July 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28736725/intraoperative-radiation-therapy-a-promising-treatment-modality-in-head-and-neck-cancer
#4
REVIEW
Lara Hilal, Karine A Al Feghali, Paul Ramia, Ibrahim Abu Gheida, Jean-Pierre Obeid, Wassim Jalbout, Bassem Youssef, Fady Geara, Youssef H Zeidan
Every year, almost 62,000 are diagnosed with a head and neck cancer (HNC) and 13,000 will succumb to their disease. In the primary setting, intraoperative radiation therapy (IORT) can be used as a boost in select patients in order to optimize local control. Addition of external beam radiation to limited volumes results in improved disease control over surgery and IORT alone. In the recurrent setting, IORT can improve outcomes from salvage surgery especially in patients previously treated with external beam radiation...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28718308/ulnar-shortening-versus-distal-radius-corrective-osteotomy-in-the-management-of-ulnar-impaction-after-distal-radius-malunion
#5
William R Aibinder, Ali Izadpanah, Bassem T Elhassan
BACKGROUND: Distal radius malunions lead to functional deficits. This study compares isolated ulnar shortening osteotomy (USO) to distal radius osteotomy (DRO) for the treatment of ulnar impaction syndrome following distal radius malunion. METHODS: We retrospectively reviewed 11 patients with extra-articular distal radius malunions treated for ulnar impaction with isolated USO. This group was compared to a 1:1 age- and sex-matched cohort treated with isolated DRO for the same indication...
January 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28705650/shoulder-function-in-patients-with-deltoid-paralysis-and-intact-rotator-cuff
#6
Jean-David Werthel, Jayme Bertelli, Bassem T Elhassan
INTRODUCTION/HYPOTHESIS: The purpose of this study is to determine the mid/long term shoulder function in patients with complete deltoid paralysis and intact rotator cuff. 27 patients with at least 2-years FU were included. MATERIALS AND METHODS: Outcome measures included pain, range of motion(including the swallowtail test, STT), deltoid extension lag test, DELT) and Bertelli, subjective fatigability using the injured shoulder and postoperative modified Neer ratings...
July 10, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28695460/inversion-technique-for-the-removal-of-partially-covered-self-expandable-metallic-stents
#7
Christine Hill, Bassem K Khalil, Sindhu Barola, Abhishek Agnihotri, Robert A Moran, Yen-I Chen, Saowanee Ngamruengphong, Vikesh K Singh, Leigh A Frame, Michael A Schweitzer, Thomas H Magnuson, Mouen A Khashab, Patrick I Okolo, Vivek Kumbhari
BACKGROUND AND AIMS: Partially covered self-expandable metallic stents (PCSEMS), although an effective treatment for anastomotic/staple line leaks and strictures, can be difficult to remove. This study examines the effectiveness of the inversion technique for the removal of PCSEMS in the treatment of leaks and strictures that occurred post-sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). METHODS: Consecutive patients who underwent PCSEMS removal for a leak and/or stricture post-SG or RYGB between July 2013 and December 2016 at the Johns Hopkins Medical Institutions were reviewed...
July 10, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28656114/a-mass-of-pancreatic-and-gastric-heterotopia-causing-a-small-bowel-obstruction-in-a-61-year-old-male
#8
Majd Alfrejat, Bassem Khalil, Jordan Jackobs, William Anderson, Jennifer Eschbacher
Heterotopic tissue is a congenital anomaly that has been previously reported. Gastric and pancreatic heterotopia are among the most studied ones. Herein, we describe a case of a combined pancreatic and gastric heterotopia that formed a mass and caused a small intestine obstruction in a 61-year-old male. We also did a brief literature review of cases with gastric and pancreatic heterotopia in adult patients.
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/28643359/an-open-8-channel-parallel-transmission-coil-for-static-and-dynamic-7t-mri-of-the-knee-and-ankle-joints-at-multiple-postures
#9
Jin Jin, Ewald Weber, Aurelien Destruel, Kieran O'Brien, Bassem Henin, Craig Engstrom, Stuart Crozier
PURPOSE: We present the initial in vivo imaging results of an open architecture eight-channel parallel transmission (pTx) transceive radiofrequency (RF) coil array that was designed and constructed for static and dynamic 7T MRI of the knee and ankle joints. METHODS: The pTx coil has a U-shaped dual-row configuration (200 mm overall length longitudinally) that allows static and dynamic imaging of the knee and ankle joints at various postures and during active movements...
June 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28590378/increasing-body-mass-index-is-associated-with-worse-outcomes-after-shoulder-arthroplasty
#10
Eric R Wagner, Matthew T Houdek, Cathy Schleck, William S Harmsen, Joaquin Sanchez-Sotelo, Robert Cofield, John W Sperling, Bassem T Elhassan
BACKGROUND: Although obesity is associated with increased complication rates after lower-extremity arthroplasty, there is a relative paucity of studies examining the effect of body mass index (BMI) on shoulder arthroplasty. The purpose of this investigation was to evaluate the effect of BMI on implant survival and the rate of complications after shoulder arthroplasty. METHODS: Using an institutional total joint registry, 4,567 consecutive shoulder arthroplasty cases from 1970 to 2013 were studied...
June 7, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28576905/cmv-and-bkpyv-infections-in-renal-transplant-recipients-receiving-an-mtor-inhibitor-based-regimen-versus-a-cni-based-regimen-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
Samir G Mallat, Bassem Y Tanios, Houssam S Itani, Tamara Lotfi, Ciaran McMullan, Steven Gabardi, Elie A Akl, Jamil R Azzi
BACKGROUND AND OBJECTIVES: The objective of this meta-analysis is to compare the incidences of cytomegalovirus and BK polyoma virus infections in renal transplant recipients receiving a mammalian target of rapamycin inhibitor (mTOR)-based regimen compared with a calcineurin inhibitor-based regimen. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a comprehensive search for randomized, controlled trials up to January of 2016 addressing our objective. Other outcomes included acute rejection, graft loss, serious adverse events, proteinuria, wound-healing complications, and eGFR...
June 2, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28554717/phenylalanine-derivatives-with-modulating-effects-on-human-%C3%AE-1-glycine-receptors-and-anticonvulsant-activity-in-strychnine-induced-seizure-model-in-male-adult-rats
#12
Bassem Sadek, Murat Oz, Syed M Nurulain, Petrilla Jayaprakash, Gniewomir Latacz, Katarzyna Kieć-Kononowicz, Ewa Szymańska
The critical role of α1-glycine receptor (α1-GLYRs) in pathological conditions such as epilepsy is well known. In the present study, structure-activity relations for a series of phenylalanine derivatives carrying selected hydrogen bond acceptors were investigated on the functional properties of human α1-GLYR expressed in Xenopus oocytes. The results indicate that one particular substitution position appeared to be of special importance for control of ligand activity. Among tested ligands (1-8), the biphenyl derivative (2) provided the most promising antagonistic effect on α1-GLYRs, while its phenylbenzyl analogue (5) exhibited the highest potentiation effect...
May 26, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28536383/design-synthesis-and-biochemical-evaluation-of-novel-selective-estrogen-receptor-ligand-conjugates-incorporating-an-endoxifen-combretastatin-hybrid-scaffold
#13
Niall O Keely, Miriam Carr, Bassem Yassin, Gloria Ana, David G Lloyd, Daniela Zisterer, Mary J Meegan
Nuclear-receptors are often overexpressed in tumours and can thereby be used as targets when designing novel selective chemotherapeutic agents. To date, many conjugates incorporating an estrogen receptor (ER) ligand have been synthesised in order to direct chemical agents to tissue sites containing ERs. A series of ER ligand conjugates were synthesised incorporating an antagonistic ER ligand scaffold based on endoxifen, covalently-bound via an amide linkage to a variety of combretastatin-based analogues, which may act as antimitotic agents...
July 20, 2016: Biomedicines
https://www.readbyqxmd.com/read/28469422/seroprevalence-of-asymptomatic-dengue-virus-infection-and-its-antibodies-among-healthy-eligible-saudi-blood-donors-findings-from-holy-makkah-city
#14
Ahmed M Ashshi, Saad Alghamdi, Adel G El-Shemi, Sabir Almdani, Bassem Refaat, Amr M Mohamed, Hani O Ghazi, Esam I Azhar, Faisal A Al-Allaf
BACKGROUND: Threat to blood transfusion-transmitted dengue virus (DENV) and its antibodies has recently emerged worldwide. Dengue fever is an endemic disease in Saudi Arabia, particularly in its Western region. The aim of this study was to estimate the seroprevalence of asymptomatic DENV infection and its antibodies among eligible Saudi blood donors. METHODS: Serum samples from 910 healthy/eligible adult male Saudi blood donors, who reside in Holy Makkah City of Saudi Arabia, were collected between March 2015 and August 2016 and screened for the detection of DENV nonstructural protein 1 (NS1) antigen and anti-DENV IgM and IgG antibodies using commercial enzyme-linked immunosorbent assay kits (Panbio, Brisbane, QLD, Australia)...
2017: Virology: Research and Treatment
https://www.readbyqxmd.com/read/28455802/gastroesophageal-reflux-disease-after-laparoscopic-sleeve-gastrectomy-with-concomitant-hiatal-hernia-repair-an-unresolved-question
#15
Hanaa Dakour Aridi, Mohammad Asali, Tarek Fouani, Ramzi S Alami, Bassem Y Safadi
PURPOSE: The effectiveness of the concomitant repair of hiatal hernia (HHR) during laparoscopic sleeve gastrectomy (LSG) in reducing gastroesophageal reflux disease (GERD) symptoms is still unclear. The aim of this study is to assess the effect of concomitant HHR on postoperative GERD symptoms in our patient population. MATERIALS AND METHODS: A retrospective review of patients who underwent LSG with or without HHR between 2011and 2014 was performed. Pre- and postoperative GERD symptoms were assessed at different time intervals until a maximum of 2 years after the surgery...
April 28, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28442411/evaluation-of-the-bioactive-extract-of-actinomyces-isolated-from-the-egyptian-environment-against-aflatoxin-b1-induce-cytotoxicity-genotoxicity-and-oxidative-stress-in-the-liver-of-rats
#16
Aziza A El-Nekeety, Asmaa S Salman, Amal S Hathout, Bassem A Sabry, Sekena H Abdel-Aziem, Nabila S Hassan, Mosaad A Abdel-Wahhab
This study aimed to determine the bioactive compounds of actinomyces (ACT) isolated from the Egyptian environment (D-EGY) and to evaluate their protective activity against AFB1 in female Sprague-Dawley rats. Six groups of animals were treated orally for 3 weeks included: C, the control group, T1, AFB1-treated group (80 μg/kg b.w), T2 and T3, the groups received ACT extract at low (25 mg/kg b.w) or high (50 mg/kg b.w) doses, T4 and T5, the groups received AFB1 plus the low or high dose of ACT extract. Blood, bone marrow and tissue samples were collected for different analyses and histological examination...
April 23, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28436881/modulating-lateral-geniculate-nucleus-neuronal-firing-for-visual-prostheses-a-kalman-filter-based-strategy
#17
Amr Jawwad, Hossam H Abolfotuh, Bassem Abdullah, Hani M K Mahdi, Seif Eldawlatly
Developing visual prostheses that target inner brain structures along the visual pathway represent a new hope for patients with completely damaged early visual pathway sites. One of the major challenges in the development of subcortical and cortical visual prostheses is tuning electrical stimulation that could optimally induce desired visual percepts. In this paper, we propose a Kalman filter-based strategy that could be used to identify electrical stimulation patterns that mimic a specific visual input for thalamic visual prostheses...
April 17, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28420381/operations-research-in-global-health-a-scoping-review-with-a-focus-on-the-themes-of-health-equity-and-impact
#18
REVIEW
Beverly D Bradley, Tiffany Jung, Ananya Tandon-Verma, Bassem Khoury, Timothy C Y Chan, Yu-Ling Cheng
BACKGROUND: Operations research (OR) is a discipline that uses advanced analytical methods (e.g. simulation, optimisation, decision analysis) to better understand complex systems and aid in decision-making. Herein, we present a scoping review of the use of OR to analyse issues in global health, with an emphasis on health equity and research impact. A systematic search of five databases was designed to identify relevant published literature. A global overview of 1099 studies highlights the geographic distribution of OR and common OR methods used...
April 18, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28410937/proximal-row-carpectomy-and-4-corner-arthrodesis-in-patients-younger-than-age%C3%A2-45-years
#19
Eric R Wagner, Jean-David Werthel, Bassem T Elhassan, Steven L Moran
PURPOSE: To examine the long-term outcome of patients aged less than 45 years who underwent either proximal row carpectomy (PRC) or 4-corner arthrodesis (4CA) for wrist arthritis. METHODS: We reviewed a retrospective cohort of 89 patients aged less than 45 years who underwent either 4CA (n = 51) or PRC (n = 38) for wrist arthritis. Mean follow-up was 11 years in the 4CA group and 18 years in the PRC group. RESULTS: Overall, there were no differences between groups in the need for revision surgery...
April 12, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28406397/evolutionary-changes-in-transcription-factor-coding-sequence-quantitatively-alter-sensory-organ-development-and-function
#20
Simon Weinberger, Matthew P Topping, Jiekun Yan, Annelies Claeys, Natalie De Geest, Duru Ozbay, Talah Hassan, Xiaoli He, Joerg T Albert, Bassem A Hassan, Ariane Ramaekers
Animals are characterized by a set of highly conserved developmental regulators. Changes in the cis-regulatory elements of these regulators are thought to constitute the major driver of morphological evolution. However, the role of coding sequence evolution remains unresolved. To address this question, we used the Atonal family of proneural transcription factors as a model. Drosophila atonal coding sequence was endogenously replaced with that of atonal homologues (ATHs) at key phylogenetic positions, non-ATH proneural genes, and the closest homologue to ancestral proneural genes...
April 13, 2017: ELife
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