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https://www.readbyqxmd.com/read/29304238/improved-right-ventricular-index-of-myocardial-performance-in-the-assessment-of-right-ventricular-function-after-coronary-artery-bypass-grafting
#1
Nashmil Hashemi, Lars-Åke Brodin, Anders Hedman, Bassem A Samad, Mahbubul Alam
OBJECTIVES: Decreased right ventricular (RV) longitudinal function following coronary artery bypass grafting (CABG), as assessed by tricuspid annular systolic excursion (TAPSE) and RV peak systolic velocity (RVS') is a known condition. We aimed to explore the feasibility of the right ventricular index of myocardial performance (RIMP) in the assessment of RV function after CABG at rest and during peak dobutamine stress echocardiography (DSE). METHODS: Forty-two patients indicated for CABG were included in this study...
January 3, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29223926/an-update-on-factor-xi-structure-and-function
#2
REVIEW
Bassem M Mohammed, Anton Matafonov, Ivan Ivanov, Mao-Fu Sun, Qiufang Cheng, S Kent Dickeson, Chan Li, David Sun, Ingrid M Verhamme, Jonas Emsley, David Gailani
Factor XI (FXI) is the zymogen of a plasma protease, factor XIa (FXIa), that contributes to thrombin generation during blood coagulation by proteolytic activation of several coagulation factors, most notably factor IX (FIX). FXI is a homolog of prekallikrein (PK), a component of the plasma kallikrein-kinin system. While sharing structural and functional features with PK, FXI has undergone adaptive changes that allow it to contribute to blood coagulation. Here we review current understanding of the biology and enzymology of FXI, with an emphasis on structural features of the protein as they relate to protease function...
January 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29222412/ancestral-perinatal-obesogen-exposure-results-in-a-transgenerational-thrifty-phenotype-in-mice
#3
Raquel Chamorro-Garcia, Carlos Diaz-Castillo, Bassem M Shoucri, Heidi Käch, Ron Leavitt, Toshi Shioda, Bruce Blumberg
Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed descendants. This transgenerational inheritance has significant implications for understanding disease etiology. Here we show that exposure of F0 mice to the obesogen tributyltin (TBT) throughout pregnancy and lactation predisposes unexposed F4 male descendants to obesity when dietary fat is increased. Analyses of body fat, plasma hormone levels, and visceral white adipose tissue DNA methylome and transcriptome collectively indicate that the F4 obesity is consistent with a leptin resistant, thrifty phenotype...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29216997/the-state-of-the-absorb-bioresorbable%C3%A2-scaffold-consensus-from-an-expert-panel
#4
REVIEW
Sripal Bangalore, Hiram G Bezerra, David G Rizik, Ehrin J Armstrong, Bruce Samuels, Srihari S Naidu, Cindy L Grines, Malcolm T Foster, James W Choi, Barry D Bertolet, Atman P Shah, Rebecca Torguson, Surendra B Avula, John C Wang, James P Zidar, Aziz Maksoud, Arun Kalyanasundaram, Steven J Yakubov, Bassem M Chehab, Anthony J Spaedy, Srini P Potluri, Ronald P Caputo, Ashok Kondur, Robert F Merritt, Amir Kaki, Ramon Quesada, Manish A Parikh, Catalin Toma, Fadi Matar, Joseph DeGregorio, William Nicholson, Wayne Batchelor, Raghava Gollapudi, Ethan Korngold, Riyaz Sumar, George S Chrysant, Jun Li, John B Gordon, Rajesh M Dave, Guilherme F Attizzani, Tom P Stys, Osvaldo S Gigliotti, Bruce E Murphy, Stephen G Ellis, Ron Waksman
Significant progress has been made in the percutaneous coronary intervention technique from the days of balloon angioplasty to modern-day metallic drug-eluting stents (DES). Although metallic stents solve a temporary problem of acute recoil following balloon angioplasty, they leave behind a permanent problem implicated in very late events (in addition to neoatherosclerosis). BRS were developed as a potential solution to this permanent problem, but the promise of these devices has been tempered by clinical trials showing increased risk of safety outcomes, both early and late...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29184281/high-intensity-laser-therapy-versus-pulsed-electromagnetic-field-in-the-treatment-of-primary-dysmenorrhea
#5
Ali Abd El-Monsif Thabet, Ahmed Mohamed Elsodany, Kadrya H Battecha, Mansour Abdullah Alshehri, Bassem Refaat
[Purpose] To determine the efficacy of high intensity laser therapy (HILT) versus pulsed electromagnetic field (PEMF) in the treatment of primary dysmenorrhea. [Subjects and Methods] This was a randomized clinical trial that included 52 girls diagnosed with primary dysmenorrhea and who were assigned randomly into two groups of equal numbers. The treatment was three sessions every cycle for three consecutive cycles where group (A) included those participants treated with HILT 15 min/session and group (B) those who were treated with PEMF 30 min/session...
October 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29174195/bacterial-lipopolysaccharide-induced-systemic-inflammation-alters-perfusion-of-white-matter-rich-regions-without-altering-flow-in-brain-irrigating-arteries-relationship-to-blood-brain-barrier-breakdown
#6
Ibtihel Dhaya, Marion Griton, Gérard Raffard, Mohamed Amri, Bassem Hiba, Jan Pieter Konsman
To better understand brain dysfunction during sepsis, cerebral arterial blood flow was assessed with Phase Contrast Magnetic Resonance Imaging, perfusion with Arterial Spin Labeling and structure with diffusion-weighted Magnetic Resonance Imaging in rats after intraperitoneal administration of bacterial lipopolysaccharides. Although cerebral arterial flow was not altered, perfusion of the corpus callosum region and diffusion parallel to its fibers were higher after lipopolysaccharide administration as compared to saline injection...
November 20, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29161928/synthesis-of-new-pyridothienopyrimidinone-and-pyridothienotriazolopyrimidine-derivatives-as-pim-1-inhibitors
#7
Hala B El-Nassan, Bassem H Naguib, Engy A Beshay
Three series of 2-arylpyridothieno[3,2-d]pyrimidin-4-ones 3a-j, pyridothienotriazolopyrimidines 6-8 and 4-imino-pyridothieno[3,2-d]pyrimidines 9a,b were prepared to improve the pim-1 inhibitory activity of the previously reported 2-arylpyridothieno[3,2-d]pyrimidin-4-ones. All the test compounds showed highly potent pim-1 inhibition with IC50 in the range of 0.06-1.76 µM. No significant difference was detected between the pim-1 inhibitory activity of the 4-pyrimidinone and the 4-imino (=NH) or the cyclised triazolopyrimidine derivatives...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29144972/building-bridges-through-science
#8
Thomas Lissek, Michelle Adams, John Adelman, Ehud Ahissar, Mohammed Akaaboune, Huda Akil, Mustafa al'Absi, Fazal Arain, Juan Carlos Arango-Lasprilla, Deniz Atasoy, Jesus Avila, Ashraf Badawi, Hilmar Bading, Abdul Mannan Baig, Jimena Baleriola, Carlos Belmonte, Ilaria Bertocchi, Heinrich Betz, Colin Blakemore, Olaf Blanke, Philipp Boehm-Sturm, Tobias Bonhoeffer, Paolo Bonifazi, Nils Brose, Patrizia Campolongo, Tansu Celikel, Cathy C Chang, Ta-Yuan Chang, Ami Citri, Hollis T Cline, Jesus M Cortes, Kathleen Cullen, Kellie Dean, José M Delgado-Garcia, Mathieu Desroches, John F Disterhoft, John E Dowling, Andreas Draguhn, Sherif F El-Khamisy, Abdeljabbar El Manira, S Ather Enam, Juan M Encinas, Asier Erramuzpe, José A Esteban, Isabel Fariñas, Edmond Fischer, Izumi Fukunaga, Iñigo Gabilondo, Detlev Ganten, Albert Gidon, Juan Carlos Gomez-Esteban, Paul Greengard, Valery Grinevich, Agnés Gruart, Roger Guillemin, Ahmad R Hariri, Bassem Hassan, Michael Häusser, Yasunori Hayashi, Natasha K Hussain, Adnan Abdul Jabbar, Mohamed Jaber, Reinhardt Jahn, Essam Mohammed Janahi, Mohamed Kabbaj, Helmut Kettenmann, Merel Kindt, Shira Knafo, Georg Köhr, Shoji Komai, Harm Krugers, Bernd Kuhn, Nouria Lakhdar Ghazal, Matthew E Larkum, Mickey London, Beat Lutz, Carlos Matute, Luis Martinez-Millan, Mouna Maroun, James McGaugh, Ahmed A Moustafa, Anwar Nasim, Klaus-Armin Nave, Erwin Neher, Karoly Nikolich, Tiago Outeiro, Lucy M Palmer, Olga Penagarikano, Isabel Perez-Otano, Donald W Pfaff, Bruno Poucet, Atta-Ur Rahman, Pedro Ramos-Cabrer, Ali Rashidy-Pour, Richard J Roberts, Serafim Rodrigues, Joshua R Sanes, Andreas T Schaefer, Menahem Segal, Idan Segev, Saad Shafqat, Nikhat Ahmed Siddiqui, Hermona Soreq, Eduardo Soriano-García, Rainer Spanagel, Rolf Sprengel, Greg Stuart, Thomas C Südhof, Jan Tønnesen, Mario Treviño, Basim M Uthman, J Craig Venter, Alexei Verkhratsky, Craig Weiss, Torsten N Wiesel, Emre Yaksi, Ofer Yizhar, Larry J Young, Paul Young, Nasser H Zawia, José L Zugaza, Mazahir T Hasan
Science is ideally suited to connect people from different cultures and thereby foster mutual understanding. To promote international life science collaboration, we have launched "The Science Bridge" initiative. Our current project focuses on partnership between Western and Middle Eastern neuroscience communities.
November 15, 2017: Neuron
https://www.readbyqxmd.com/read/29102248/nociceptin-and-the-nop-receptor-in-aversive-learning-in-mice
#9
Abdu Adem, Nather Madjid, Ulrika Kahl, Sarah Holst, Bassem Sadek, Johan Sandin, Lars Terenius, Sven Ove Ögren
The endogenous neuropeptide nociceptin (N/OFQ), which mediates its actions via the nociceptin receptor (NOP), is implicated in multiple behavioural and physiological functions. This study examined the effects of the NOP agonists N/OFQ and the synthetic agonist Ro 64-6198, the antagonists NNN and NalBzoH, as well as deletion of the Pronociceptin gene on emotional memory in mice. The animals were tested in the passive avoidance (PA) task, dependent on hippocampal and amygdala functions. N/OFQ injected intraventricularly (i...
October 25, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29101313/anaplastic-meningioma-presenting-as-a-left-parietal-mass-a-case-report
#10
Marwan W Najjar, Nour H Abdul Halim, Fares R Sukhon, Bassem Youssef, Hazem I Assi
BACKGROUND Meningiomas are slow-growing tumors attached to the dura mater and are composed of neoplastic meningothelial cells. The tumors are most commonly located in convexities, and it is relatively rare to find such a growth in the parietal region such as the one presented in this case report. CASE REPORT Because of its uncommon presentation, we hereby report the case of a 67-year-old, previously healthy, white Lebanese female patient who presented with forgetfulness, unsteady gait, right-sided motor weakness, and dysphagia...
November 4, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29099727/supplemental-computational-phantoms-to-estimate-out-of-field-absorbed-dose-in-photon-radiotherapy
#11
Kyle Joseph Gallagher, Jaad Tannous, Racile Nabha, Joelle Ann Feghali, Zeina Ayoub, Wassim T Jalbout, Bassem Youssef, Phillip J Taddei
The purpose of this study was to develop a straightforward method of supplementing patient anatomy and estimating out-of-field absorbed dose for a cohort of pediatric radiotherapy patients with limited recorded anatomy. A cohort of nine children, aged 2 to 14 years, who received three-dimensional conformal radiotherapy for low grade localized brain tumors (LBTs), were randomly selected for this study. The extents of these patients' computed tomography simulation image sets were cranial only. To approximate their missing anatomy, we supplemented the LBT patients' image sets with computed tomography images of patients in a previous study with larger extents of matched sex, height, and mass and for whom contours of organs at risk for radiogenic cancer had already been delineated...
November 3, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29094096/model-for-estimating-power-and-downtime-effects-on-teletherapy-units-in-low-resource-settings
#12
Rachel McCarroll, Bassem Youssef, Beth Beadle, Maureen Bojador, Rex Cardan, Robin Famiglietti, David Followill, Geoffrey Ibbott, Anuja Jhingran, Christoph Trauernicht, Peter Balter, Laurence Court
Purpose: More than 6,500 megavoltage teletherapy units are needed worldwide, many in low-resource settings. Cobalt-60 units or linear accelerators (linacs) can fill this need. We have evaluated machine performance on the basis of patient throughput to provide insight into machine viability under various conditions in such a way that conclusions can be generalized to a vast array of clinical scenarios. Materials and Methods: Data from patient treatment plans, peer-reviewed studies, and international organizations were combined to assess the relative patient throughput of linacs and cobalt-60 units that deliver radiotherapy with standard techniques under various power and maintenance support conditions...
October 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29082048/corrigendum-to-a-mass-of-pancreatic-and-gastric-heterotopia-causing-a-small-bowel-obstruction-in-a-61-year-old-male
#13
Majd Alfreijat, Bassem Khalil, Jordan Jackobs, William Anderson, Jennifer Eschbacher
[This corrects the article DOI: 10.1155/2017/3126108.].
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29079566/swine-atrioventricular-node-ablation-using-stereotactic-radiosurgery-methods-and-in-vivo-feasibility-investigation-for-catheter-free-ablation-of-cardiac-arrhythmias
#14
Marwan M Refaat, Jad A Ballout, Patrick Zakka, Mostafa Hotait, Karine A Al Feghali, Ibrahim Abu Gheida, Charbel Saade, Mukbil Hourani, Fady Geara, Malek Tabbal, Pierre Sfeir, Wassim Jalbout, Wael Al-Jaroudi, Abdo Jurjus, Bassem Youssef
BACKGROUND: Linear accelerator-based stereotactic radiosurgery delivered to cardiac arrhythmogenic foci could be a promising catheter-free ablation modality. We tested the feasibility of in vivo atrioventricular (AV) node ablation in swine using stereotactic radiosurgery. METHODS AND RESULTS: Five Large White breed swine (weight 40-75 kg; 4 females) were studied. Single-chamber St Jude pacemakers were implanted in each pig. The pigs were placed under general anesthesia, and coronary/cardiac computed tomography simulation scans were performed to localize the AV node...
October 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29078261/antiproliferative-and-apoptosis-inducing-effects-of-citral-via-p53-and-ros-induced-mitochondrial-mediated-apoptosis-in-human-colorectal-hct116-and-ht29-cell-lines
#15
Bassem Y Sheikh, Md Moklesur Rahman Sarker, Muhamad Noor Alfarizal Kamarudin, Gokula Mohan
Despite various anticancer reports, antiproliferative and apoptosis inducing activity of citral in HCT116 and HT29 cells have never been reported. This study aimed to evaluate the cytotoxic and apoptosis inducing effects of citral in colorectal cancer cell lines. The citral-treated cells were subjected to MTT assay followed by flow cytometric Annexin V-FITC/PI, mitochondrial membrane potential and intracellular reactive oxygen species (ROS) determination. The apoptotic proteins expression was investigated by Western blot analysis...
October 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29075190/the-histamine-h3-receptor-antagonist-e159-reverses-memory-deficits-induced-by-dizocilpine-in-passive-avoidance-and-novel-object-recognition-paradigm-in-rats
#16
Alaa Alachkar, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek
The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established. Therefore, the effects of histamine H3 receptor (H3R) antagonist E159 (2.5-10 mg/kg, i.p.) in adult male rats on dizocilpine (DIZ)-induced memory deficits were studied in passive avoidance paradigm (PAP) and in novel object recognition (NOR) using pitolisant (PIT) and donepezil (DOZ) as standard drugs...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29060300/exploration-and-validation-of-alternate-sensing-methods-for-wearable-continuous-pulse-transit-time-measurement-using-optical-and-bioimpedance-modalities
#17
Bassem Ibrahim, Viswam Nathan, Roozbeh Jafari
In this work we explore the viability of a multimodal sensing device that can be integrated in a wearable form factor for daily, non-invasive ambulatory blood pressure (BP) monitoring. A common approach in previous research has been to rely on measuring the pulse transit time (PTT), which has been shown to be correlated with the BP. In this work, we look into the feasibility of measuring PTT using sensors separated by a small distance on one arm so that any eventual realization of the system is convenient to wear and use over long periods of time...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059116/management-of-failed-rotator-cuff-repair-in-young-patients
#18
Bassem T Elhassan, Ryan M Cox, Dave R Shukla, Julia Lee, Anand M Murthi, Robert Z Tashjian, Joseph A Abboud
Management of failed rotator cuff repair may be difficult, especially in young patients. Various nonmodifiable and modifiable patient factors, including age, tendon quality, rotator cuff tear characteristics, acute or chronic rotator cuff tear, bone quality, tobacco use, and medications, affect rotator cuff repair healing. Surgical variables, such as the technique, timing, tension on the repair, the biomechanical construct, and fixation, as well as the postoperative rehabilitation strategy also affect rotator cuff repair healing...
November 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29055705/biochemical-and-molecular-characterization-of-a-novel-metalloprotease-from-pseudomonas-fluorescens-strain-tbs09
#19
Souraya Boulkour Touioui, Nadia Zaraî Jaouadi, Khelifa Bouacem, Rayda Ben Ayed, Hatem Rekik, Bilal Zenati, Sidali Kourdali, Hadjira Boudjella, Nasserdine Sabaou, Samir Bejar, Mouhamed El Hattab, Abdelmalek Badis, Rachid Annane, Bassem Jaouadi
A novel extracellular protease called MPDZ was purified and characterized from Pseudomonas fluorescens strain TBS09. The enzymatic properties of MPDZ were investigated using biochemical and biophysical methods. Matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF/MS) analysis revealed that it was a monomer with a molecular mass of 50013.17Da. The NH2-terminal 27 amino acid sequence of MPDZ showed high homology with those of Pseudomonas-proteases of the serralysin family. MPDZ showed optimal activity at pH 7 and 60°C...
October 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29046393/rac1-stimulated-macropinocytosis-enhances-g%C3%AE-%C3%AE-activation-of-pi3k%C3%AE
#20
Zahra Erami, Bassem D Khalil, Gilbert Salloum, Yanhua Yao, Jaclyn LoPiccolo, Aliaksei Shymanets, Bernd Nürnberg, Anne R Bresnick, Jonathan M Backer
Phosphoinositide 3-kinases (PI 3-kinases) are regulated by a diverse range of upstream activators, including receptor tyrosine kinases (RTKs), G-protein-coupled receptors (GPCRs), and small GTPases from the Ras, Rho and Rab families. For the Class IA PI 3-kinase PI3Kβ, two mechanisms for GPCR-mediated regulation have been described: direct binding of Gβγ subunits to the C2-helical domain linker of p110β, and Dock180/Elmo1-mediated activation of Rac1, which binds to the Ras-Binding Domain of p110β. We now show that the integration of these dual pathways is unexpectedly complex...
November 16, 2017: Biochemical Journal
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